FLT1 (fms related receptor tyrosine kinase 1) - Rat Genome Database

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Gene: FLT1 (fms related receptor tyrosine kinase 1) Pan paniscus
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Symbol: FLT1
Name: fms related receptor tyrosine kinase 1
RGD ID: 11946529
Description: ENCODES a protein that exhibits ATP binding (ortholog); growth factor binding (ortholog); identical protein binding (ortholog); INVOLVED IN angiogenesis (ortholog); blood vessel morphogenesis (ortholog); branching involved in blood vessel morphogenesis (ortholog); PARTICIPATES IN axitinib pharmacodynamics pathway; bevacizumab pharmacodynamics pathway; glypican signaling pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); allergic contact dermatitis (ortholog); angiosarcoma (ortholog); FOUND IN actin cytoskeleton (ortholog); cytosol (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: fms related tyrosine kinase 1; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor); vascular endothelial growth factor receptor 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21427,891,381 - 28,086,068 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11318,995,989 - 19,190,679 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0139,584,850 - 9,779,542 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11327,926,256 - 28,120,493 (-)NCBIpanpan1.1PanPan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (ISO)
allergic contact dermatitis  (ISO)
angiosarcoma  (ISO)
arteriovenous malformations of the brain  (ISO)
atrial fibrillation  (ISO)
autism spectrum disorder  (ISO)
background diabetic retinopathy  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
bronchopulmonary dysplasia  (ISO)
cerebral cavernous malformation  (ISO)
Cerebral Hemorrhage  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Choroidal Neovascularization  (ISO)
chronic obstructive pulmonary disease  (ISO)
colon carcinoma  (ISO)
corneal neovascularization  (ISO)
Coronary Disease  (ISO)
COVID-19  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Disease Progression  (ISO)
ductal carcinoma in situ  (ISO)
Endometrial Neoplasms  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
hydrophthalmos  (ISO)
ischemia  (ISO)
Kawasaki disease  (ISO)
Kidney Neoplasms  (ISO)
Kuhnt-Junius degeneration  (ISO)
leiomyosarcoma  (ISO)
Leydig cell tumor  (ISO)
liver cirrhosis  (ISO)
lung adenocarcinoma  (ISO)
macular degeneration  (ISO)
macular retinal edema  (ISO)
melanoma  (ISO)
Mycoplasma pneumoniae pneumonia  (ISO)
myocardial infarction  (ISO)
nasopharynx carcinoma  (ISO)
Neointima  (ISO)
Neoplasm Metastasis  (ISO)
nephroblastoma  (ISO)
osteoarthritis  (ISO)
Osteoarthritis, Experimental  (ISO)
osteochondrodysplasia  (ISO)
Otitis Media with Effusion  (ISO)
Ovarian Neoplasms  (ISO)
pre-eclampsia  (ISO)
proliferative diabetic retinopathy  (ISO)
prostate carcinoma in situ  (ISO)
Prostatic Neoplasms  (ISO)
psoriasis  (ISO)
Recurrence  (ISO)
renal cell carcinoma  (ISO)
retinopathy of prematurity  (ISO)
Sepsis  (ISO)
Skin Neoplasms  (ISO)
Spinal Cord Injuries  (ISO)
squamous cell carcinoma  (ISO)
thyroid gland carcinoma  (ISO)
transient cerebral ischemia  (ISO)
type 2 diabetes mellitus  (ISO)
uremia  (ISO)
Uterine Cervical Neoplasms  (ISO)
Uterine Neoplasms  (ISO)
vascular dementia  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (ISO)
blood vessel morphogenesis  (ISO)
branching involved in blood vessel morphogenesis  (ISO)
cell migration  (ISO)
cell surface receptor protein tyrosine kinase signaling pathway  (IEA)
cellular response to hypoxia  (ISO)
cellular response to vascular endothelial growth factor stimulus  (ISO)
embryonic morphogenesis  (ISO)
female pregnancy  (ISO)
homophilic cell adhesion via plasma membrane adhesion molecules  (IEA)
hyaloid vascular plexus regression  (ISO)
intracellular receptor signaling pathway  (ISO)
liver regeneration  (ISO)
monocyte chemotaxis  (ISO)
negative regulation of sprouting angiogenesis  (ISO)
negative regulation of vascular endothelial cell proliferation  (ISO)
negative regulation of vascular endothelial growth factor production  (ISO)
peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of glial cell proliferation  (ISO)
positive regulation of hematopoietic progenitor cell differentiation  (ISO)
positive regulation of MAP kinase activity  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of vascular permeability  (ISO)
post-embryonic camera-type eye morphogenesis  (ISO)
protein autophosphorylation  (ISO)
protein phosphorylation  (ISO)
regulation of smooth muscle contraction  (ISO)
response to activity  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to hypoxia  (ISO)
sprouting angiogenesis  (ISO)
vascular endothelial growth factor receptor signaling pathway  (IEA,ISO)
vascular endothelial growth factor receptor-1 signaling pathway  (ISO)
vascular endothelial growth factor signaling pathway  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
FLT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21427,891,381 - 28,086,068 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11318,995,989 - 19,190,679 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0139,584,850 - 9,779,542 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11327,926,256 - 28,120,493 (-)NCBIpanpan1.1PanPan1.1panPan2
FLT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381328,300,346 - 28,495,128 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1328,300,346 - 28,495,145 (-)EnsemblGRCh38hg38GRCh38
GRCh371328,874,483 - 29,069,265 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361327,774,389 - 27,967,265 (-)NCBINCBI36Build 36hg18NCBI36
Build 341327,773,789 - 27,967,232NCBI
Celera139,949,266 - 10,144,048 (-)NCBICelera
Cytogenetic Map13q12.3NCBI
HuRef139,695,411 - 9,890,006 (-)NCBIHuRef
CHM1_11328,842,736 - 29,037,594 (-)NCBICHM1_1
T2T-CHM13v2.01327,522,576 - 27,717,351 (-)NCBIT2T-CHM13v2.0
Flt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395147,498,414 - 147,663,419 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5147,498,414 - 147,662,821 (-)EnsemblGRCm39 Ensembl
GRCm385147,561,604 - 147,726,438 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5147,561,604 - 147,726,011 (-)EnsemblGRCm38mm10GRCm38
MGSCv375148,373,772 - 148,537,564 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365147,872,545 - 148,036,337 (-)NCBIMGSCv36mm8
Celera5145,555,589 - 145,721,706 (-)NCBICelera
Cytogenetic Map5G3NCBI
cM Map587.01NCBI
Flt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81212,333,050 - 12,504,750 (+)NCBIGRCr8
mRatBN7.2127,296,899 - 7,468,626 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl127,297,292 - 7,468,626 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx127,981,040 - 8,154,378 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0128,604,183 - 8,777,515 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0127,632,184 - 7,805,529 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0129,033,993 - 9,205,886 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl129,034,308 - 9,205,905 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01210,927,827 - 10,959,880 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4127,858,092 - 8,035,966 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera129,039,046 - 9,210,055 (+)NCBICelera
RH 3.4 Map12 RGD
Cytogenetic Map12p11NCBI
Flt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554977,653,248 - 7,831,472 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554977,653,309 - 7,831,737 (-)NCBIChiLan1.0ChiLan1.0
FLT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12511,231,958 - 11,410,379 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2511,231,737 - 11,407,621 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2511,295,043 - 11,473,288 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02511,359,770 - 11,538,425 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2511,360,101 - 11,538,419 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12511,255,914 - 11,434,257 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02511,248,371 - 11,426,845 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02511,290,416 - 11,468,726 (+)NCBIUU_Cfam_GSD_1.0
Flt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945172,334,859 - 172,512,069 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647223,440,088 - 23,617,041 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647223,442,946 - 23,617,523 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FLT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl115,621,212 - 5,795,264 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1115,620,698 - 5,797,095 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2115,307,309 - 5,483,546 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FLT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.137,412,506 - 7,608,122 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl37,412,172 - 7,607,967 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605736,781,262 - 36,977,028 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Flt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477610,043,258 - 10,219,104 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477610,043,113 - 10,218,598 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


RefSeq Acc Id: XM_003818327   ⟹   XP_003818375
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21427,891,381 - 28,086,068 (-)NCBI
NHGRI_mPanPan11318,995,989 - 19,190,679 (-)NCBI
Mhudiblu_PPA_v0139,584,850 - 9,779,542 (-)NCBI
PanPan1.11327,926,256 - 28,120,492 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008971604   ⟹   XP_008969852
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21427,956,113 - 28,086,067 (-)NCBI
NHGRI_mPanPan11319,063,765 - 19,190,678 (-)NCBI
Mhudiblu_PPA_v0139,652,599 - 9,779,537 (-)NCBI
PanPan1.11327,993,646 - 28,120,492 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034936503   ⟹   XP_034792394
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21427,976,744 - 28,086,067 (-)NCBI
NHGRI_mPanPan11319,081,373 - 19,190,678 (-)NCBI
Mhudiblu_PPA_v0139,670,143 - 9,779,537 (-)NCBI
Protein Sequences
Protein RefSeqs XP_003818375 (Get FASTA)   NCBI Sequence Viewer  
  XP_008969852 (Get FASTA)   NCBI Sequence Viewer  
  XP_034792394 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000020116.1
  ENSPPAP00000020120.1
RefSeq Acc Id: XP_003818375   ⟸   XM_003818327
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008969852   ⟸   XM_008971604
- Peptide Label: isoform X2
- UniProtKB: A0A2R9AS02 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034792394   ⟸   XM_034936503
- Peptide Label: isoform X3
- UniProtKB: A0A2R9AWE1 (UniProtKB/TrEMBL),   A0A2R9AS02 (UniProtKB/TrEMBL)
Protein Domains
Ig-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000033250 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000042902.1 UniProtKB/TrEMBL
  ENSPPAT00000042906.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro Cell_Adh-Cytoskel_Orgn UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_I-set UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  Ig_V-set UniProtKB/TrEMBL
  Immunoglobulin UniProtKB/TrEMBL
  PDGFRL UniProtKB/TrEMBL
  VEGFR1-3_5th UniProtKB/TrEMBL
  VEGFR1-3_N_Ig-like UniProtKB/TrEMBL
  VEGFR1_rcpt UniProtKB/TrEMBL
NCBI Gene FLT1 ENTREZGENE
PANTHER CONTACTIN 5 UniProtKB/TrEMBL
  IG-LIKE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  PLATELET-DERIVED GROWTH FACTOR RECEPTOR LIKE UniProtKB/TrEMBL
  PLATELET-DERIVED GROWTH FACTOR RECEPTOR-LIKE PROTEIN UniProtKB/TrEMBL
Pfam I-set UniProtKB/TrEMBL
  Ig_3 UniProtKB/TrEMBL
  PF00047 UniProtKB/TrEMBL
  VEGFR-1-like_5th UniProtKB/TrEMBL
  VEGFR-1-like_Ig-like UniProtKB/TrEMBL
  VEGFR1-3_N_Ig-like UniProtKB/TrEMBL
PIRSF TyrPK_CSF1-R UniProtKB/TrEMBL
PRINTS VEGFRECEPTOR UniProtKB/TrEMBL
  VEGFRECEPTR1 UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
SMART IGc2 UniProtKB/TrEMBL
  IGv UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt A0A2R9AS02 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9AWE1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-12-10 FLT1  fms related receptor tyrosine kinase 1  FLT1  fms related tyrosine kinase 1  Symbol and/or name change 5135510 APPROVED