Flt1 (fms related receptor tyrosine kinase 1) - Rat Genome Database

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Gene: Flt1 (fms related receptor tyrosine kinase 1) Chinchilla lanigera
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Symbol: Flt1
Name: fms related receptor tyrosine kinase 1
RGD ID: 8807323
Description: ENCODES a protein that exhibits ATP binding (ortholog); growth factor binding (ortholog); identical protein binding (ortholog); INVOLVED IN aging (ortholog); angiogenesis (ortholog); blood vessel morphogenesis (ortholog); PARTICIPATES IN axitinib pharmacodynamics pathway; bevacizumab pharmacodynamics pathway; glypican signaling pathway; ASSOCIATED WITH Acute Lung Injury (ortholog); allergic contact dermatitis (ortholog); angiosarcoma (ortholog); FOUND IN actin cytoskeleton (ortholog); extracellular space (ortholog); integral component of plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: fms related tyrosine kinase 1; fms-related tyrosine kinase 1; vascular endothelial growth factor receptor 1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554977,653,248 - 7,831,472 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554977,653,309 - 7,831,737 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (ISO)
allergic contact dermatitis  (ISO)
angiosarcoma  (ISO)
arteriovenous malformations of the brain  (ISO)
atrial fibrillation  (ISO)
background diabetic retinopathy  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
Bronchopulmonary Dysplasia  (ISO)
cerebral cavernous malformation  (ISO)
Cerebral Hemorrhage  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Choroidal Neovascularization  (ISO)
chronic obstructive pulmonary disease  (ISO)
colon carcinoma  (ISO)
corneal neovascularization  (ISO)
Coronary Disease  (ISO)
COVID-19  (ISO)
Diabetic Nephropathies  (ISO)
diabetic retinopathy  (ISO)
Disease Progression  (ISO)
ductal carcinoma in situ  (ISO)
Endometrial Neoplasms  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
hydrophthalmos  (ISO)
ischemia  (ISO)
Kawasaki disease  (ISO)
Kidney Neoplasms  (ISO)
Kuhnt-Junius degeneration  (ISO)
leiomyosarcoma  (ISO)
Leydig cell tumor  (ISO)
liver cirrhosis  (ISO)
macular degeneration  (ISO)
macular retinal edema  (ISO)
melanoma  (ISO)
Mycoplasma pneumoniae pneumonia  (ISO)
myocardial infarction  (ISO)
Neointima  (ISO)
Neoplasm Metastasis  (ISO)
nephroblastoma  (ISO)
osteoarthritis  (ISO)
Osteoarthritis, Experimental  (ISO)
osteochondrodysplasia  (ISO)
Otitis Media with Effusion  (ISO)
Ovarian Neoplasms  (ISO)
pre-eclampsia  (ISO)
proliferative diabetic retinopathy  (ISO)
prostate carcinoma in situ  (ISO)
Prostatic Neoplasms  (ISO)
psoriasis  (ISO)
Recurrence  (ISO)
renal cell carcinoma  (ISO)
retinopathy of prematurity  (ISO)
Sepsis  (ISO)
Skin Neoplasms  (ISO)
Spinal Cord Injuries  (ISO)
transient cerebral ischemia  (ISO)
type 2 diabetes mellitus  (ISO)
uremia  (ISO)
Uterine Cervical Neoplasms  (ISO)
Uterine Neoplasms  (ISO)
vascular dementia  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
angiogenesis  (ISO)
blood vessel morphogenesis  (ISO)
branching involved in blood vessel morphogenesis  (ISO)
cell migration  (ISO)
cellular response to hypoxia  (ISO)
cellular response to vascular endothelial growth factor stimulus  (ISO)
embryonic morphogenesis  (ISO)
female pregnancy  (ISO)
hyaloid vascular plexus regression  (ISO)
intracellular receptor signaling pathway  (ISO)
liver regeneration  (ISO)
monocyte chemotaxis  (ISO)
negative regulation of sprouting angiogenesis  (ISO)
negative regulation of vascular endothelial cell proliferation  (ISO)
negative regulation of vascular endothelial growth factor production  (ISO)
peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of glial cell proliferation  (ISO)
positive regulation of hematopoietic progenitor cell differentiation  (ISO)
positive regulation of MAP kinase activity  (ISO)
positive regulation of MAPK cascade  (ISO)
positive regulation of phosphatidylinositol 3-kinase activity  (ISO)
positive regulation of phosphatidylinositol 3-kinase signaling  (ISO)
positive regulation of phospholipase C activity  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of vascular permeability  (ISO)
post-embryonic camera-type eye morphogenesis  (ISO)
protein autophosphorylation  (ISO)
protein phosphorylation  (ISO)
regulation of smooth muscle contraction  (ISO)
response to activity  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to hypoxia  (ISO)
sprouting angiogenesis  (ISO)
vascular endothelial growth factor receptor signaling pathway  (ISO)
vascular endothelial growth factor receptor-1 signaling pathway  (ISO)

Cellular Component

References


Genomics

Comparative Map Data
Flt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554977,653,248 - 7,831,472 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554977,653,309 - 7,831,737 (-)NCBIChiLan1.0ChiLan1.0
FLT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1328,300,346 - 28,495,145 (-)EnsemblGRCh38hg38GRCh38
GRCh381328,300,346 - 28,495,128 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371328,874,483 - 29,069,265 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361327,774,389 - 27,967,265 (-)NCBINCBI36hg18NCBI36
Build 341327,773,789 - 27,967,232NCBI
Celera139,949,266 - 10,144,048 (-)NCBI
Cytogenetic Map13q12.3NCBI
HuRef139,695,411 - 9,890,006 (-)NCBIHuRef
CHM1_11328,842,736 - 29,037,594 (-)NCBICHM1_1
Flt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395147,498,414 - 147,663,419 (-)NCBIGRCm39mm39
GRCm39 Ensembl5147,498,414 - 147,662,821 (-)Ensembl
GRCm385147,561,604 - 147,726,438 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5147,561,604 - 147,726,011 (-)EnsemblGRCm38mm10GRCm38
MGSCv375148,373,772 - 148,537,564 (-)NCBIGRCm37mm9NCBIm37
MGSCv365147,872,545 - 148,036,337 (-)NCBImm8
Celera5145,555,589 - 145,721,706 (-)NCBICelera
Cytogenetic Map5G3NCBI
cM Map587.01NCBI
Flt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2127,296,899 - 7,468,626 (+)NCBI
Rnor_6.0 Ensembl129,034,308 - 9,205,905 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0129,033,993 - 9,205,886 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01210,927,827 - 10,959,880 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4127,858,092 - 8,035,966 (+)NCBIRGSC3.4rn4RGSC3.4
Celera129,039,046 - 9,210,055 (+)NCBICelera
RH 3.4 Map12 RGD
Cytogenetic Map12p11NCBI
FLT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11327,926,256 - 28,120,493 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0139,584,850 - 9,779,542 (-)NCBIMhudiblu_PPA_v0panPan3
FLT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12511,231,958 - 11,410,379 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2511,231,737 - 11,407,621 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2511,295,043 - 11,473,288 (+)NCBI
ROS_Cfam_1.02511,359,770 - 11,538,425 (+)NCBI
UMICH_Zoey_3.12511,255,914 - 11,434,257 (+)NCBI
UNSW_CanFamBas_1.02511,248,371 - 11,426,845 (+)NCBI
UU_Cfam_GSD_1.02511,290,416 - 11,468,726 (+)NCBI
Flt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945172,334,859 - 172,512,069 (+)NCBI
SpeTri2.0NW_00493647223,442,946 - 23,617,523 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FLT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl115,620,700 - 5,795,264 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1115,620,698 - 5,797,095 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2115,307,309 - 5,483,546 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FLT1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.137,412,506 - 7,608,122 (-)NCBI
ChlSab1.1 Ensembl37,412,172 - 7,607,967 (-)Ensembl
Flt1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477610,043,113 - 10,218,598 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000012012   ⟹   ENSCLAP00000011873
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554977,653,248 - 7,831,472 (-)Ensembl
RefSeq Acc Id: XM_005406358   ⟹   XP_005406415
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554977,653,309 - 7,831,737 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005406359   ⟹   XP_005406416
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554977,653,309 - 7,831,737 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005406360   ⟹   XP_005406417
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554977,731,683 - 7,831,737 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005406415 (Get FASTA)   NCBI Sequence Viewer  
  XP_005406416 (Get FASTA)   NCBI Sequence Viewer  
  XP_005406417 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005406416   ⟸   XM_005406359
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_005406415   ⟸   XM_005406358
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005406417   ⟸   XM_005406360
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSCLAP00000011873   ⟸   ENSCLAT00000012012


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000008187 Ensembl, ENTREZGENE
Ensembl Protein ENSCLAP00000011873 ENTREZGENE
Ensembl Transcript ENSCLAT00000012012 ENTREZGENE
NCBI Gene Flt1 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-12-10 Flt1  fms related receptor tyrosine kinase 1  Flt1  fms related tyrosine kinase 1  Symbol and/or name change 5135510 APPROVED
2016-08-03 Flt1  fms related tyrosine kinase 1    fms-related tyrosine kinase 1  Symbol and/or name change 5135510 APPROVED