FLT1 (fms related receptor tyrosine kinase 1) - Rat Genome Database
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Gene: FLT1 (fms related receptor tyrosine kinase 1) Homo sapiens
Analyze
Symbol: FLT1
Name: fms related receptor tyrosine kinase 1
RGD ID: 737202
HGNC Page HGNC
Description: Exhibits growth factor binding activity and transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including monocyte chemotaxis; positive regulation of kinase activity; and protein phosphorylation. Localizes to actin cytoskeleton; integral component of plasma membrane; and receptor complex. Implicated in Kuhnt-Junius degeneration; diabetic retinopathy; and pre-eclampsia. Biomarker of several diseases, including Kawasaki disease; Leydig cell tumor; cerebrovascular disease (multiple); kidney cancer (multiple); and retinal disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLT; FLT-1; fms related tyrosine kinase 1; fms-like tyrosine kinase 1; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor); tyrosine-protein kinase FRT; tyrosine-protein kinase receptor FLT; vascular endothelial growth factor receptor 1; vascular permeability factor receptor; VEGFR-1; VEGFR1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: FLT1P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1328,300,346 - 28,495,145 (-)EnsemblGRCh38hg38GRCh38
GRCh381328,300,346 - 28,495,128 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371328,874,483 - 29,069,265 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361327,774,389 - 27,967,265 (-)NCBINCBI36hg18NCBI36
Build 341327,773,789 - 27,967,232NCBI
Celera139,949,266 - 10,144,048 (-)NCBI
Cytogenetic Map13q12.3NCBI
HuRef139,695,411 - 9,890,006 (-)NCBIHuRef
CHM1_11328,842,736 - 29,037,594 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (ISO)
allergic contact dermatitis  (IEP)
angiosarcoma  (EXP)
arteriovenous malformations of the brain  (IEP)
atrial fibrillation  (IEP)
background diabetic retinopathy  (IEP)
breast cancer  (ISO)
Breast Neoplasms  (EXP,IEP)
Bronchopulmonary Dysplasia  (IDA)
cerebral cavernous malformation  (IEP)
Cerebral Hemorrhage  (EXP,ISO)
Chemical and Drug Induced Liver Injury  (EXP)
Choroidal Neovascularization  (IDA,ISO)
chronic obstructive pulmonary disease  (IEP)
colon carcinoma  (IAGP)
corneal neovascularization  (ISO)
Coronary Disease  (IEP)
COVID-19  (HEP)
Diabetic Nephropathies  (IEP)
diabetic retinopathy  (IMP,ISO)
Disease Progression  (EXP)
ductal carcinoma in situ  (IEP)
Endometrial Neoplasms  (IEP)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (IDA)
Experimental Diabetes Mellitus  (ISO)
hydrophthalmos  (ISO)
ischemia  (ISO)
Kawasaki disease  (IEP)
Kidney Neoplasms  (IEP)
Kuhnt-Junius degeneration  (IAGP,IEP,IMP)
leiomyosarcoma  (IEP)
Leydig cell tumor  (IEP)
liver cirrhosis  (EXP,ISO)
macular degeneration  (ISO)
macular retinal edema  (IEP)
melanoma  (EXP,IEP)
Mycoplasma pneumoniae pneumonia  (HEP)
myocardial infarction  (ISO)
Neointima  (ISO)
Neoplasm Metastasis  (EXP)
nephroblastoma  (IEP)
osteoarthritis  (IEP)
Osteoarthritis, Experimental  (IDA)
osteochondrodysplasia  (EXP)
Otitis Media with Effusion  (ISO)
Ovarian Neoplasms  (IEP,IMP,ISO)
pre-eclampsia  (EXP,IDA)
proliferative diabetic retinopathy  (IEP)
prostate carcinoma in situ  (IEP)
Prostatic Neoplasms  (IAGP,IEP)
psoriasis  (IEP)
Recurrence  (EXP)
renal cell carcinoma  (EXP,IEP)
retinopathy of prematurity  (ISO)
Sepsis  (IEP)
Skin Neoplasms  (EXP)
Spinal Cord Injuries  (ISO)
transient cerebral ischemia  (ISO)
type 2 diabetes mellitus  (ISO)
uremia  (EXP)
Uterine Cervical Neoplasms  (IEP)
Uterine Neoplasms  (IEP)
vascular dementia  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (EXP)
(R)-lipoic acid  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-fluorouracil  (ISO)
5-Hydroxycapric acid  (EXP)
Actein  (ISO)
afimoxifene  (EXP)
aflatoxin B1  (EXP)
aflatoxin B2  (EXP)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (ISO)
aluminium oxide  (EXP)
ammonium chloride  (ISO)
andrographolide  (EXP)
arsenous acid  (EXP,ISO)
belinostat  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (EXP)
bilirubin IXalpha  (EXP)
biphenyl-2-ol  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromochloroacetic acid  (ISO)
C60 fullerene  (ISO)
cadmium atom  (EXP)
calcitriol  (EXP)
carbon nanotube  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP)
cholesterol  (EXP)
choline  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (ISO)
crocidolite asbestos  (EXP)
curcumin  (EXP,ISO)
cyclosporin A  (ISO)
D-glucose  (EXP)
DAPT  (ISO)
dexamethasone  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP,ISO)
diazoxide  (EXP)
dioxygen  (EXP,ISO)
disodium selenite  (EXP)
diuron  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
edaravone  (EXP)
entinostat  (EXP)
ethanol  (ISO)
eugenol  (ISO)
fenvalerate  (ISO)
fipronil  (ISO)
flavonoids  (ISO)
folic acid  (ISO)
formaldehyde  (EXP)
furosemide  (ISO)
geldanamycin  (EXP)
gentamycin  (ISO)
glucose  (EXP)
hydralazine  (ISO)
hydrochlorothiazide  (ISO)
indoles  (ISO)
isoprenaline  (ISO)
L-ascorbic acid  (EXP)
L-methionine  (ISO)
lanreotide  (ISO)
lipoic acid  (ISO)
losartan  (ISO)
manganese(II) chloride  (ISO)
mercury dibromide  (EXP)
methamphetamine  (ISO)
methapyrilene  (EXP)
methyl methanesulfonate  (EXP)
methylmercury chloride  (EXP)
mifepristone  (ISO)
monosodium L-glutamate  (ISO)
N-acetyl-L-cysteine  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (EXP)
nickel sulfate  (EXP)
Nilvadipine  (ISO)
NS 1619  (EXP)
orphenadrine  (ISO)
oxaliplatin  (EXP)
paclitaxel  (ISO)
panobinostat  (EXP)
paracetamol  (EXP,ISO)
Paxilline  (EXP)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenobarbital  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
phosgene  (ISO)
ponatinib  (EXP)
potassium dichromate  (ISO)
progesterone  (ISO)
protein kinase inhibitor  (EXP)
rac-lactic acid  (EXP)
rebaudioside A  (EXP)
resveratrol  (EXP)
rotenone  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 431542  (EXP)
serpentine asbestos  (ISO)
silicon dioxide  (EXP)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenite  (EXP)
steviol  (EXP)
stevioside  (EXP)
streptozocin  (ISO)
sunitinib  (EXP)
tauroursodeoxycholic acid  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (ISO)
trichostatin A  (EXP)
troglitazone  (ISO)
tunicamycin  (ISO)
tyrphostin AG 1478  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
Verbenalin  (EXP)
vinclozolin  (ISO)
vincristine  (EXP)
vorinostat  (EXP)
zinc atom  (EXP,ISO)
zinc protoporphyrin  (EXP)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of MAPKK activity  (ISO)
aging  (ISO)
angiogenesis  (IEA)
blood vessel morphogenesis  (ISS)
branching involved in blood vessel morphogenesis  (ISO)
cell migration  (IBA,IMP)
cellular response to hypoxia  (ISO)
cellular response to vascular endothelial growth factor stimulus  (IDA)
embryonic morphogenesis  (ISS)
female pregnancy  (ISO)
hematopoietic progenitor cell differentiation  (IBA)
hyaloid vascular plexus regression  (ISS)
intracellular receptor signaling pathway  (ISO)
liver regeneration  (ISO)
monocyte chemotaxis  (IDA)
multicellular organism development  (IBA)
negative regulation of sprouting angiogenesis  (ISO)
negative regulation of vascular endothelial cell proliferation  (IGI)
negative regulation of vascular endothelial growth factor production  (ISO)
peptidyl-tyrosine phosphorylation  (IDA,IEA)
positive regulation of angiogenesis  (IBA,IMP)
positive regulation of cell migration  (IDA)
positive regulation of cell population proliferation  (TAS)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of glial cell proliferation  (ISO)
positive regulation of hematopoietic progenitor cell differentiation  (ISO)
positive regulation of kinase activity  (IBA)
positive regulation of MAP kinase activity  (IDA)
positive regulation of MAPK cascade  (IDA)
positive regulation of phosphatidylinositol 3-kinase activity  (IMP)
positive regulation of phosphatidylinositol 3-kinase signaling  (IMP)
positive regulation of phospholipase C activity  (IMP)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of vascular permeability  (ISO)
post-embryonic camera-type eye morphogenesis  (ISO)
protein autophosphorylation  (IDA)
protein phosphorylation  (IEA)
regulation of smooth muscle contraction  (ISO)
response to activity  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to hypoxia  (ISO)
sprouting angiogenesis  (ISO)
transmembrane receptor protein tyrosine kinase signaling pathway  (IBA)
vascular endothelial growth factor receptor signaling pathway  (IDA,IEA,IMP,TAS)
vascular endothelial growth factor receptor-1 signaling pathway  (IDA)
vascular endothelial growth factor signaling pathway  (IEA)

Cellular Component

References

References - curated
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Additional References at PubMed
PMID:1312256   PMID:2158038   PMID:3040650   PMID:3115921   PMID:7657594   PMID:7707437   PMID:8111406   PMID:8126087   PMID:8248162   PMID:8605350   PMID:8621427   PMID:9256359  
PMID:9269752   PMID:9299537   PMID:9393862   PMID:9398617   PMID:9452434   PMID:9472937   PMID:9600074   PMID:9722576   PMID:9751730   PMID:9790910   PMID:9931493   PMID:9973224  
PMID:10194760   PMID:10409677   PMID:10471394   PMID:10543948   PMID:10579917   PMID:10585578   PMID:10642585   PMID:10737800   PMID:10738243   PMID:10748050   PMID:10749680   PMID:10842181  
PMID:10865839   PMID:11056124   PMID:11134362   PMID:11157498   PMID:11278319   PMID:11289156   PMID:11312102   PMID:11513746   PMID:11693202   PMID:11741094   PMID:11751905   PMID:11806246  
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PMID:12133473   PMID:12366396   PMID:12406876   PMID:12426207   PMID:12439912   PMID:12477932   PMID:12509223   PMID:12543719   PMID:12607599   PMID:12651930   PMID:12670505   PMID:12727995  
PMID:12771128   PMID:12796773   PMID:12810700   PMID:12865438   PMID:12920240   PMID:12949011   PMID:14512169   PMID:14585871   PMID:14600159   PMID:14602804   PMID:14607815   PMID:14633857  
PMID:14654077   PMID:14674128   PMID:14684734   PMID:14687619   PMID:14702039   PMID:14760936   PMID:14967383   PMID:14996703   PMID:15135240   PMID:15160911   PMID:15166498   PMID:15183893  
PMID:15272021   PMID:15284201   PMID:15329326   PMID:15489334   PMID:15492987   PMID:15503825   PMID:15589171   PMID:15610528   PMID:15649874   PMID:15665766   PMID:15705187   PMID:15711751  
PMID:15735759   PMID:15817508   PMID:15817662   PMID:15886253   PMID:15952180   PMID:16005848   PMID:16021053   PMID:16021077   PMID:16095053   PMID:16109918   PMID:16169405   PMID:16248895  
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PMID:16685275   PMID:16786116   PMID:16835828   PMID:16893970   PMID:16959214   PMID:16968555   PMID:17013089   PMID:17051153   PMID:17071533   PMID:17088944   PMID:17109193   PMID:17118734  
PMID:17189520   PMID:17197602   PMID:17210583   PMID:17242190   PMID:17259514   PMID:17287067   PMID:17336974   PMID:17379761   PMID:17409768   PMID:17486129   PMID:17507435   PMID:17550303  
PMID:17562275   PMID:17570036   PMID:17599955   PMID:17615362   PMID:17633783   PMID:17661207   PMID:17696935   PMID:17722983   PMID:17891484   PMID:17956952   PMID:17956955   PMID:17964871  
PMID:17975225   PMID:17982238   PMID:18006819   PMID:18029348   PMID:18037256   PMID:18053608   PMID:18079407   PMID:18097592   PMID:18175241   PMID:18175242   PMID:18264952   PMID:18273061  
PMID:18284215   PMID:18287964   PMID:18295763   PMID:18304425   PMID:18315732   PMID:18317954   PMID:18330824   PMID:18332870   PMID:18343373   PMID:18356031   PMID:18374411   PMID:18379030  
PMID:18421240   PMID:18443354   PMID:18451223   PMID:18515749   PMID:18566591   PMID:18593464   PMID:18598002   PMID:18604718   PMID:18609713   PMID:18625704   PMID:18627789   PMID:18631405  
PMID:18636124   PMID:18639520   PMID:18656381   PMID:18665074   PMID:18691902   PMID:18694994   PMID:18771978   PMID:18779584   PMID:18789115   PMID:18829111   PMID:18931684   PMID:18936439  
PMID:18974372   PMID:18975312   PMID:18992679   PMID:18996083   PMID:19003637   PMID:19020728   PMID:19039203   PMID:19064815   PMID:19066962   PMID:19068081   PMID:19082506   PMID:19103251  
PMID:19135290   PMID:19147226   PMID:19162007   PMID:19165674   PMID:19200976   PMID:19261502   PMID:19269632   PMID:19287991   PMID:19302266   PMID:19324337   PMID:19330612   PMID:19336504  
PMID:19350449   PMID:19351908   PMID:19352513   PMID:19385972   PMID:19409555   PMID:19412349   PMID:19452502   PMID:19453261   PMID:19501525   PMID:19528353   PMID:19564559   PMID:19608702  
PMID:19631980   PMID:19633424   PMID:19658040   PMID:19701853   PMID:19707156   PMID:19716155   PMID:19718025   PMID:19720604   PMID:19734545   PMID:19741061   PMID:19811263   PMID:19816083  
PMID:19816604   PMID:19834490   PMID:19850021   PMID:19860625   PMID:19895348   PMID:19913121   PMID:19919522   PMID:19936766   PMID:19948974   PMID:19953087   PMID:20007583   PMID:20015944  
PMID:20026801   PMID:20030917   PMID:20103598   PMID:20103604   PMID:20124108   PMID:20149032   PMID:20158393   PMID:20164029   PMID:20169144   PMID:20179233   PMID:20199197   PMID:20222950  
PMID:20223440   PMID:20350647   PMID:20395257   PMID:20422012   PMID:20428821   PMID:20452482   PMID:20453000   PMID:20484670   PMID:20488538   PMID:20491879   PMID:20501651   PMID:20512933  
PMID:20515481   PMID:20571438   PMID:20602615   PMID:20615131   PMID:20628086   PMID:20635108   PMID:20660291   PMID:20661303   PMID:20666936   PMID:20673868   PMID:20674013   PMID:20695190  
PMID:20706192   PMID:20805333   PMID:20828367   PMID:20842453   PMID:20854187   PMID:20873967   PMID:20948996   PMID:21050477   PMID:21062661   PMID:21097568   PMID:21115742   PMID:21139021  
PMID:21168388   PMID:21209384   PMID:21212275   PMID:21212411   PMID:21219538   PMID:21286681   PMID:21300889   PMID:21334711   PMID:21336717   PMID:21343372   PMID:21345006   PMID:21349629  
PMID:21371321   PMID:21376261   PMID:21381877   PMID:21382012   PMID:21389678   PMID:21389833   PMID:21415391   PMID:21423176   PMID:21447646   PMID:21448460   PMID:21487788   PMID:21496870  
PMID:21518965   PMID:21524919   PMID:21532145   PMID:21534854   PMID:21544626   PMID:21555675   PMID:21568945   PMID:21585639   PMID:21596751   PMID:21612582   PMID:21642504   PMID:21652578  
PMID:21709213   PMID:21715541   PMID:21751212   PMID:21827221   PMID:21867402   PMID:21873635   PMID:21939291   PMID:21939755   PMID:21962138   PMID:21978169   PMID:22000672   PMID:22016416  
PMID:22034638   PMID:22082645   PMID:22095559   PMID:22147121   PMID:22153185   PMID:22173504   PMID:22177802   PMID:22178822   PMID:22203927   PMID:22203933   PMID:22230112   PMID:22246525  
PMID:22264588   PMID:22294840   PMID:22315135   PMID:22348624   PMID:22357551   PMID:22385323   PMID:22386962   PMID:22427682   PMID:22438952   PMID:22484977   PMID:22487430   PMID:22528855  
PMID:22541785   PMID:22555639   PMID:22558992   PMID:22581286   PMID:22609636   PMID:22690749   PMID:22718299   PMID:22729710   PMID:22734007   PMID:22819145   PMID:22828632   PMID:22836649  
PMID:22872542   PMID:22902831   PMID:22955733   PMID:22962618   PMID:22988942   PMID:23030842   PMID:23038639   PMID:23059888   PMID:23113309   PMID:23113927   PMID:23140147   PMID:23172303  
PMID:23190621   PMID:23195033   PMID:23239021   PMID:23250775   PMID:23339636   PMID:23364394   PMID:23382219   PMID:23397142   PMID:23400753   PMID:23415672   PMID:23420665   PMID:23421954  
PMID:23437230   PMID:23475388   PMID:23503608   PMID:23567329   PMID:23580180   PMID:23602568   PMID:23612628   PMID:23620752   PMID:23624620   PMID:23645683   PMID:23645757   PMID:23701307  
PMID:23704979   PMID:23711375   PMID:23716179   PMID:23725155   PMID:23737988   PMID:23748230   PMID:23749886   PMID:23772669   PMID:23774235   PMID:23794399   PMID:23795287   PMID:23799140  
PMID:23799978   PMID:23801279   PMID:23806447   PMID:23831629   PMID:23902770   PMID:23905610   PMID:23912175   PMID:23925400   PMID:23939615   PMID:23957293   PMID:23966056   PMID:24035323  
PMID:24041258   PMID:24048373   PMID:24098721   PMID:24127643   PMID:24166749   PMID:24217170   PMID:24260556   PMID:24303885   PMID:24304210   PMID:24340742   PMID:24341227   PMID:24354578  
PMID:24380505   PMID:24398900   PMID:24400721   PMID:24419917   PMID:24423299   PMID:24440566   PMID:24482236   PMID:24484391   PMID:24485669   PMID:24535301   PMID:24583918   PMID:24595913  
PMID:24636199   PMID:24664213   PMID:24675699   PMID:24708917   PMID:24713547   PMID:24714697   PMID:24719187   PMID:24724970   PMID:24763231   PMID:24880209   PMID:24885632   PMID:24891316  
PMID:24903330   PMID:24903995   PMID:24908415   PMID:25007257   PMID:25053574   PMID:25128974   PMID:25141961   PMID:25202119   PMID:25241761   PMID:25256553   PMID:25257525   PMID:25329517  
PMID:25329693   PMID:25340839   PMID:25387128   PMID:25388629   PMID:25434840   PMID:25491486   PMID:25544745   PMID:25601765   PMID:25604142   PMID:25647613   PMID:25756047   PMID:25797229  
PMID:25862844   PMID:25880726   PMID:25894226   PMID:25895461   PMID:25948043   PMID:25965397   PMID:25970161   PMID:25979342   PMID:25979720   PMID:26007312   PMID:26014353   PMID:26041938  
PMID:26058077   PMID:26082458   PMID:26083681   PMID:26116870   PMID:26124351   PMID:26134224   PMID:26159901   PMID:26191229   PMID:26203176   PMID:26204137   PMID:26228018   PMID:26238275  
PMID:26261265   PMID:26352069   PMID:26394830   PMID:26416849   PMID:26434493   PMID:26450920   PMID:26526582   PMID:26551737   PMID:26623725   PMID:26627848   PMID:26642248   PMID:26666815  
PMID:26699385   PMID:26728997   PMID:26783205   PMID:26791355   PMID:26819475   PMID:26910493   PMID:26914796   PMID:26988336   PMID:27049304   PMID:27067718   PMID:27103202   PMID:27140908  
PMID:27151212   PMID:27167339   PMID:27169826   PMID:27178307   PMID:27287686   PMID:27315098   PMID:27357606   PMID:27401249   PMID:27417418   PMID:27424135   PMID:27431361   PMID:27464822  
PMID:27503620   PMID:27590851   PMID:27599390   PMID:27604660   PMID:27629739   PMID:27664209   PMID:27668980   PMID:27736948   PMID:27793555   PMID:27833959   PMID:27834501   PMID:27859593  
PMID:27863935   PMID:27865093   PMID:27874074   PMID:27901483   PMID:27983995   PMID:27986932   PMID:28029641   PMID:28067578   PMID:28111021   PMID:28121958   PMID:28145862   PMID:28220020  
PMID:28246215   PMID:28301910   PMID:28322131   PMID:28323906   PMID:28335685   PMID:28358369   PMID:28368336   PMID:28454690   PMID:28468595   PMID:28494174   PMID:28494189   PMID:28498441  
PMID:28501276   PMID:28514442   PMID:28552862   PMID:28589930   PMID:28609170   PMID:28609171   PMID:28609172   PMID:28613009   PMID:28628106   PMID:28637396   PMID:28652462   PMID:28680264  
PMID:28718364   PMID:28732797   PMID:28737473   PMID:28770473   PMID:28797294   PMID:28817576   PMID:28820403   PMID:28849176   PMID:28869250   PMID:28927814   PMID:28939845   PMID:28949775  
PMID:28991928   PMID:29138037   PMID:29149180   PMID:29205570   PMID:29226875   PMID:29235095   PMID:29267975   PMID:29282362   PMID:29351188   PMID:29409879   PMID:29481086   PMID:29497919  
PMID:29509796   PMID:29523274   PMID:29523275   PMID:29548823   PMID:29674192   PMID:29674197   PMID:29674208   PMID:29719170   PMID:29734754   PMID:29749553   PMID:29795307   PMID:29845518  
PMID:29971632   PMID:30015524   PMID:30032672   PMID:30099798   PMID:30106204   PMID:30173595   PMID:30177039   PMID:30177066   PMID:30277426   PMID:30316329   PMID:30401688   PMID:30409050  
PMID:30413130   PMID:30423986   PMID:30478339   PMID:30576228   PMID:30636550   PMID:30674935   PMID:30700502   PMID:30758082   PMID:30824181   PMID:30831776   PMID:30835584   PMID:30879360  
PMID:30882594   PMID:30929546   PMID:30950008   PMID:31200683   PMID:31240525   PMID:31289124   PMID:31291799   PMID:31300808   PMID:31327483   PMID:31335509   PMID:31444934   PMID:31510832  
PMID:31559879   PMID:31564130   PMID:31669240   PMID:31717527   PMID:31734756   PMID:31744542   PMID:31755001   PMID:31982041   PMID:32035919   PMID:32088190   PMID:32236632   PMID:32790760  
PMID:32929141  


Genomics

Comparative Map Data
FLT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1328,300,346 - 28,495,145 (-)EnsemblGRCh38hg38GRCh38
GRCh381328,300,346 - 28,495,128 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371328,874,483 - 29,069,265 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361327,774,389 - 27,967,265 (-)NCBINCBI36hg18NCBI36
Build 341327,773,789 - 27,967,232NCBI
Celera139,949,266 - 10,144,048 (-)NCBI
Cytogenetic Map13q12.3NCBI
HuRef139,695,411 - 9,890,006 (-)NCBIHuRef
CHM1_11328,842,736 - 29,037,594 (-)NCBICHM1_1
Flt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395147,498,414 - 147,663,419 (-)NCBIGRCm39mm39
GRCm385147,561,604 - 147,726,438 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5147,561,604 - 147,726,011 (-)EnsemblGRCm38mm10GRCm38
MGSCv375148,373,772 - 148,537,564 (-)NCBIGRCm37mm9NCBIm37
MGSCv365147,872,545 - 148,036,337 (-)NCBImm8
Celera5145,555,589 - 145,721,706 (-)NCBICelera
Cytogenetic Map5G3NCBI
cM Map587.01NCBI
Flt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0129,033,993 - 9,205,886 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl129,034,308 - 9,205,905 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01210,927,827 - 10,959,880 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4127,858,092 - 8,035,966 (+)NCBIRGSC3.4rn4RGSC3.4
Celera129,039,046 - 9,210,055 (+)NCBICelera
Cytogenetic Map12p11NCBI
RH 3.4 Map12 RGD
Flt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554977,653,248 - 7,831,472 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554977,653,309 - 7,831,737 (-)NCBIChiLan1.0ChiLan1.0
FLT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11327,926,256 - 28,120,493 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0139,584,850 - 9,779,542 (-)NCBIMhudiblu_PPA_v0panPan3
FLT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2511,231,737 - 11,407,621 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12511,231,958 - 11,410,379 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Flt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493647223,442,946 - 23,617,523 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FLT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl115,620,700 - 5,795,264 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1115,620,698 - 5,797,095 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2115,307,309 - 5,483,546 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FLT1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.137,412,506 - 7,608,122 (-)NCBI
ChlSab1.1 Ensembl37,412,172 - 7,607,967 (-)Ensembl
Flt1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462477610,043,113 - 10,218,598 (+)NCBI

Position Markers
D13S1250  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371328,923,525 - 28,923,686UniSTSGRCh37
Build 361327,821,525 - 27,821,686RGDNCBI36
Celera139,998,289 - 9,998,452RGD
Cytogenetic Map13q12UniSTS
HuRef139,744,473 - 9,744,636UniSTS
Marshfield Genetic Map1317.21UniSTS
Marshfield Genetic Map1317.21RGD
Genethon Genetic Map1319.1UniSTS
deCODE Assembly Map1321.52UniSTS
RH44391  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371328,961,953 - 28,962,124UniSTSGRCh37
Build 361327,859,953 - 27,860,124RGDNCBI36
Celera1310,036,720 - 10,036,891RGD
Cytogenetic Map13q12UniSTS
HuRef139,782,714 - 9,782,885UniSTS
GeneMap99-GB4 RH Map1383.07UniSTS
RH47290  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371328,874,645 - 28,874,770UniSTSGRCh37
Build 361327,772,645 - 27,772,770RGDNCBI36
Celera139,949,428 - 9,949,547RGD
Cytogenetic Map13q12UniSTS
HuRef139,695,573 - 9,695,710UniSTS
GeneMap99-GB4 RH Map1378.1UniSTS
RH70263  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371328,875,027 - 28,875,151UniSTSGRCh37
GRCh37346,180,448 - 46,180,569UniSTSGRCh37
Build 36346,155,452 - 46,155,573RGDNCBI36
Celera139,949,804 - 9,949,928UniSTS
Celera346,117,781 - 46,117,902RGD
Cytogenetic Map13q12UniSTS
HuRef139,695,967 - 9,696,091UniSTS
HuRef346,224,267 - 46,224,388UniSTS
RH104153  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371328,875,288 - 28,875,476UniSTSGRCh37
Build 361327,773,288 - 27,773,476RGDNCBI36
Celera139,950,065 - 9,950,253RGD
Cytogenetic Map13q12UniSTS
HuRef139,696,228 - 9,696,419UniSTS
GeneMap99-GB4 RH Map1386.09UniSTS
RH104465  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371328,883,294 - 28,883,454UniSTSGRCh37
Build 361327,781,294 - 27,781,454RGDNCBI36
Celera139,958,070 - 9,958,230RGD
Cytogenetic Map13q12UniSTS
HuRef139,704,237 - 9,704,397UniSTS
GeneMap99-GB4 RH Map1385.36UniSTS
RH119940  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371328,927,023 - 28,927,293UniSTSGRCh37
Build 361327,825,023 - 27,825,293RGDNCBI36
Celera1310,001,789 - 10,002,059RGD
Cytogenetic Map13q12UniSTS
TNG Radiation Hybrid Map135159.0UniSTS
RH122752  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371328,997,172 - 28,997,445UniSTSGRCh37
Build 361327,895,172 - 27,895,445RGDNCBI36
Celera1310,071,957 - 10,072,230RGD
Cytogenetic Map13q12UniSTS
HuRef139,817,951 - 9,818,224UniSTS
TNG Radiation Hybrid Map135197.0UniSTS
G60554  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371328,923,510 - 28,923,794UniSTSGRCh37
Build 361327,821,510 - 27,821,794RGDNCBI36
Celera139,998,274 - 9,998,560RGD
Cytogenetic Map13q12UniSTS
HuRef139,744,458 - 9,744,744UniSTS
TNG Radiation Hybrid Map135153.0UniSTS
TNG Radiation Hybrid Map455308.0UniSTS
RH118501  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371328,941,405 - 28,941,713UniSTSGRCh37
Build 361327,839,405 - 27,839,713RGDNCBI36
Celera1310,016,171 - 10,016,479RGD
Cytogenetic Map13q12UniSTS
HuRef139,762,356 - 9,762,664UniSTS
TNG Radiation Hybrid Map135165.0UniSTS
TNG Radiation Hybrid Map135171.0UniSTS
D13S992  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371329,052,753 - 29,052,940UniSTSGRCh37
Build 361327,950,753 - 27,950,940RGDNCBI36
Celera1310,127,539 - 10,127,726RGD
Cytogenetic Map13q12UniSTS
HuRef139,873,495 - 9,873,682UniSTS
D13S666E  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371328,961,774 - 28,961,891UniSTSGRCh37
Build 361327,859,774 - 27,859,891RGDNCBI36
Celera1310,036,539 - 10,036,656RGD
Cytogenetic Map13q12UniSTS
HuRef139,782,533 - 9,782,650UniSTS
GDB:180246  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371328,874,548 - 28,874,719UniSTSGRCh37
Build 361327,772,548 - 27,772,719RGDNCBI36
Celera139,949,331 - 9,949,496RGD
Cytogenetic Map13q12UniSTS
HuRef139,695,476 - 9,695,659UniSTS
GDB:190836  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371328,876,469 - 28,876,700UniSTSGRCh37
Build 361327,774,469 - 27,774,700RGDNCBI36
Celera139,951,246 - 9,951,477RGD
Cytogenetic Map13q12UniSTS
HuRef139,697,412 - 9,697,643UniSTS
GDB:218013  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371328,874,639 - 28,874,733UniSTSGRCh37
Build 361327,772,639 - 27,772,733RGDNCBI36
Celera139,949,422 - 9,949,510RGD
Cytogenetic Map13q12UniSTS
HuRef139,695,567 - 9,695,673UniSTS
Flt1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371328,875,760 - 28,875,926UniSTSGRCh37
GRCh37346,181,176 - 46,181,338UniSTSGRCh37
GRCh37346,184,757 - 46,184,859UniSTSGRCh37
Build 36346,159,761 - 46,159,863RGDNCBI36
Celera346,122,089 - 46,122,191RGD
Celera346,118,509 - 46,118,671UniSTS
Celera139,950,537 - 9,950,703UniSTS
HuRef346,228,575 - 46,228,677UniSTS
HuRef346,224,995 - 46,225,157UniSTS
HuRef139,696,703 - 9,696,869UniSTS
FLT1_2504  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371328,875,691 - 28,876,373UniSTSGRCh37
Build 361327,773,691 - 27,774,373RGDNCBI36
Celera139,950,468 - 9,951,150RGD
HuRef139,696,634 - 9,697,316UniSTS
A006V36  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371328,959,751 - 28,959,960UniSTSGRCh37
Build 361327,857,751 - 27,857,960RGDNCBI36
Celera1310,034,516 - 10,034,725RGD
Cytogenetic Map13q12UniSTS
HuRef139,780,510 - 9,780,719UniSTS
GeneMap99-GB4 RH Map1385.05UniSTS
NCBI RH Map13198.9UniSTS
D13S1520  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371328,912,243 - 28,912,388UniSTSGRCh37
Build 361327,810,243 - 27,810,388RGDNCBI36
Celera139,987,007 - 9,987,152RGD
HuRef139,733,187 - 9,733,332UniSTS
D13S1539  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371484,162,891 - 84,163,022UniSTSGRCh37
GRCh371328,917,532 - 28,917,665UniSTSGRCh37
Build 361327,815,532 - 27,815,665RGDNCBI36
Celera1464,207,503 - 64,207,634UniSTS
Celera139,992,296 - 9,992,429RGD
HuRef1464,332,134 - 64,332,265UniSTS
HuRef139,738,475 - 9,738,608UniSTS
D13S1715  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371328,886,143 - 28,886,234UniSTSGRCh37
GRCh37346,184,397 - 46,184,488UniSTSGRCh37
Build 36346,159,401 - 46,159,492RGDNCBI36
Celera139,960,920 - 9,961,011UniSTS
Celera346,121,729 - 46,121,820RGD
Cytogenetic Map13q12UniSTS
HuRef139,707,100 - 9,707,191UniSTS
HuRef346,228,215 - 46,228,306UniSTS
RH17924  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371328,877,325 - 28,877,470UniSTSGRCh37
Build 361327,775,325 - 27,775,470RGDNCBI36
Celera139,952,102 - 9,952,247RGD
Cytogenetic Map13q12UniSTS
GeneMap99-GB4 RH Map1385.68UniSTS
D13S1448  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371329,050,133 - 29,050,359UniSTSGRCh37
Build 361327,948,133 - 27,948,359RGDNCBI36
Celera1310,124,919 - 10,125,145RGD
Cytogenetic Map13q12UniSTS
HuRef139,870,875 - 9,871,101UniSTS
Whitehead-RH Map1355.8UniSTS
Whitehead-YAC Contig Map13 UniSTS
D13S1819  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371328,874,638 - 28,874,788UniSTSGRCh37
Build 361327,772,638 - 27,772,788RGDNCBI36
Celera139,949,421 - 9,949,565RGD
Cytogenetic Map13q12UniSTS
HuRef139,695,566 - 9,695,728UniSTS
HuRef346,223,896 - 46,224,025UniSTS
A006Q11  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371328,961,901 - 28,962,009UniSTSGRCh37
Build 361327,859,901 - 27,860,009RGDNCBI36
Celera1310,036,666 - 10,036,776RGD
Cytogenetic Map13q12UniSTS
HuRef139,782,660 - 9,782,770UniSTS
GeneMap99-GB4 RH Map1386.82UniSTS
RH48311  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371329,070,914 - 29,071,084UniSTSGRCh37
Build 361327,968,914 - 27,969,084RGDNCBI36
Celera1310,145,697 - 10,145,867RGD
Cytogenetic Map13q12UniSTS
HuRef139,891,655 - 9,891,825UniSTS
GeneMap99-GB4 RH Map1386.82UniSTS
NCBI RH Map13218.5UniSTS
RH65559  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371329,040,754 - 29,040,874UniSTSGRCh37
Build 361327,938,754 - 27,938,874RGDNCBI36
Celera1310,115,534 - 10,115,654RGD
Cytogenetic Map13q12UniSTS
HuRef139,861,494 - 9,861,614UniSTS
GeneMap99-GB4 RH Map1386.51UniSTS
FLT1-112  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371328,877,117 - 28,877,491UniSTSGRCh37
Build 361327,775,117 - 27,775,491RGDNCBI36
Celera139,951,894 - 9,952,268RGD
HuRef139,698,060 - 9,698,434UniSTS
WI-7567  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371328,875,731 - 28,875,979UniSTSGRCh37
GRCh37346,181,147 - 46,182,480UniSTSGRCh37
Build 361327,773,731 - 27,773,979RGDNCBI36
Celera346,118,480 - 46,119,813UniSTS
Celera139,950,508 - 9,950,756RGD
Cytogenetic Map13q12UniSTS
HuRef139,696,674 - 9,696,922UniSTS
HuRef346,224,966 - 46,226,299UniSTS
GeneMap99-GB4 RH Map1386.61UniSTS
Whitehead-RH Map1363.3UniSTS
Whitehead-YAC Contig Map13 UniSTS
Flt1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371328,875,760 - 28,875,926UniSTSGRCh37
GRCh37346,181,176 - 46,181,338UniSTSGRCh37
GRCh37346,184,757 - 46,184,859UniSTSGRCh37
Build 36346,159,761 - 46,159,863RGDNCBI36
Celera346,122,089 - 46,122,191RGD
Celera346,118,509 - 46,118,671UniSTS
Celera139,950,537 - 9,950,703UniSTS
HuRef346,228,575 - 46,228,677UniSTS
HuRef346,224,995 - 46,225,157UniSTS
HuRef139,696,703 - 9,696,869UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR200Bhsa-miR-200b-3pOncomiRDBexternal_infoNANA21115742
MIR200Ahsa-miR-200a-3pOncomiRDBexternal_infoNANA21115742
MIR100hsa-miR-100-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22955733
MIR200Chsa-miR-200c-3pOncomiRDBexternal_infoNANA21115742

Predicted Target Of
Summary Value
Count of predictions:1768
Count of miRNA genes:922
Interacting mature miRNAs:1088
Transcripts:ENST00000282397, ENST00000539099, ENST00000540678, ENST00000541932, ENST00000543394
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component
High
Medium 715 1073 899 88 295 72 1887 824 1712 242 578 1295 17 1178 952 2
Low 1611 1390 768 487 1028 341 2432 1330 1939 132 786 136 148 1 26 1825 2
Below cutoff 49 520 40 37 597 39 27 29 39 20 55 106 6 11 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_012003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001159920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001160030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001160031 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_002019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011535014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017020485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB209050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF063657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK092472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK292936 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK300392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK309901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL138712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL139005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC029849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC039007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE180461 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU151621 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX504049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA396081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471075 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CQ871317 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS172284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D00133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA844548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA851664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ836394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ836395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ836396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF484674 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF491868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF491869 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF491870 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU332841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU360600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU368830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU443152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU826561 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU826562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HD077716 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JF509744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JF509745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JX512442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF002712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF002713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF206396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF206397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF206398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF206399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF680656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF680657 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF680658 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF680659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF680660 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF680661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF680662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF680663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF854284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF854285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF897924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF897925 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S77812 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S77814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U01134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000282397   ⟹   ENSP00000282397
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1328,300,346 - 28,495,128 (-)Ensembl
RefSeq Acc Id: ENST00000539099   ⟹   ENSP00000442630
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1328,399,044 - 28,495,128 (-)Ensembl
RefSeq Acc Id: ENST00000540678   ⟹   ENSP00000443311
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1328,303,144 - 28,346,289 (-)Ensembl
RefSeq Acc Id: ENST00000541932   ⟹   ENSP00000437631
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1328,368,096 - 28,495,128 (-)Ensembl
RefSeq Acc Id: ENST00000543394   ⟹   ENSP00000437841
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1328,303,134 - 28,322,633 (-)Ensembl
RefSeq Acc Id: ENST00000615611   ⟹   ENSP00000484385
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1328,303,126 - 28,328,415 (-)Ensembl
RefSeq Acc Id: ENST00000615840   ⟹   ENSP00000484039
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1328,385,548 - 28,495,079 (-)Ensembl
RefSeq Acc Id: ENST00000617835   ⟹   ENSP00000484832
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1328,303,126 - 28,308,434 (-)Ensembl
RefSeq Acc Id: ENST00000639477   ⟹   ENSP00000491097
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1328,385,567 - 28,495,145 (-)Ensembl
RefSeq Acc Id: NM_001159920   ⟹   NP_001153392
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381328,385,548 - 28,495,128 (-)NCBI
GRCh371328,874,483 - 29,069,265 (-)ENTREZGENE
HuRef139,695,411 - 9,890,006 (-)ENTREZGENE
CHM1_11328,927,911 - 29,037,594 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001160030   ⟹   NP_001153502
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381328,368,092 - 28,495,128 (-)NCBI
GRCh371328,874,483 - 29,069,265 (-)ENTREZGENE
HuRef139,695,411 - 9,890,006 (-)ENTREZGENE
CHM1_11328,910,476 - 29,037,594 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001160031   ⟹   NP_001153503
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381328,399,044 - 28,495,128 (-)NCBI
GRCh371328,874,483 - 29,069,265 (-)ENTREZGENE
HuRef139,695,411 - 9,890,006 (-)ENTREZGENE
CHM1_11328,941,404 - 29,037,594 (-)NCBI
Sequence:
RefSeq Acc Id: NM_002019   ⟹   NP_002010
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381328,300,346 - 28,495,128 (-)NCBI
GRCh371328,874,483 - 29,069,265 (-)ENTREZGENE
Build 361327,774,389 - 27,967,265 (-)NCBI Archive
HuRef139,695,411 - 9,890,006 (-)ENTREZGENE
CHM1_11328,842,736 - 29,037,594 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011535014   ⟹   XP_011533316
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381328,383,195 - 28,495,128 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017020485   ⟹   XP_016875974
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381328,300,346 - 28,495,128 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001153392 (Get FASTA)   NCBI Sequence Viewer  
  NP_001153502 (Get FASTA)   NCBI Sequence Viewer  
  NP_001153503 (Get FASTA)   NCBI Sequence Viewer  
  NP_002010 (Get FASTA)   NCBI Sequence Viewer  
  XP_011533316 (Get FASTA)   NCBI Sequence Viewer  
  XP_016875974 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB34001 (Get FASTA)   NCBI Sequence Viewer  
  AAB34002 (Get FASTA)   NCBI Sequence Viewer  
  AAC16449 (Get FASTA)   NCBI Sequence Viewer  
  AAC50060 (Get FASTA)   NCBI Sequence Viewer  
  AAH39007 (Get FASTA)   NCBI Sequence Viewer  
  ABI53803 (Get FASTA)   NCBI Sequence Viewer  
  ABI53804 (Get FASTA)   NCBI Sequence Viewer  
  ABI53805 (Get FASTA)   NCBI Sequence Viewer  
  ABS32268 (Get FASTA)   NCBI Sequence Viewer  
  ABS32269 (Get FASTA)   NCBI Sequence Viewer  
  ABS32270 (Get FASTA)   NCBI Sequence Viewer  
  ABY87530 (Get FASTA)   NCBI Sequence Viewer  
  ACA21474 (Get FASTA)   NCBI Sequence Viewer  
  ACA62948 (Get FASTA)   NCBI Sequence Viewer  
  ACB05747 (Get FASTA)   NCBI Sequence Viewer  
  ACF47597 (Get FASTA)   NCBI Sequence Viewer  
  ACF47598 (Get FASTA)   NCBI Sequence Viewer  
  AFC77954 (Get FASTA)   NCBI Sequence Viewer  
  AFC77955 (Get FASTA)   NCBI Sequence Viewer  
  AGC09589 (Get FASTA)   NCBI Sequence Viewer  
  AGL73885 (Get FASTA)   NCBI Sequence Viewer  
  AGL73886 (Get FASTA)   NCBI Sequence Viewer  
  AGS56393 (Get FASTA)   NCBI Sequence Viewer  
  AGS56394 (Get FASTA)   NCBI Sequence Viewer  
  AHC08482 (Get FASTA)   NCBI Sequence Viewer  
  AHC08483 (Get FASTA)   NCBI Sequence Viewer  
  AHC08484 (Get FASTA)   NCBI Sequence Viewer  
  AHC08485 (Get FASTA)   NCBI Sequence Viewer  
  AHC08486 (Get FASTA)   NCBI Sequence Viewer  
  AHC08487 (Get FASTA)   NCBI Sequence Viewer  
  AHC08488 (Get FASTA)   NCBI Sequence Viewer  
  AHC08489 (Get FASTA)   NCBI Sequence Viewer  
  AHO49114 (Get FASTA)   NCBI Sequence Viewer  
  AHO49115 (Get FASTA)   NCBI Sequence Viewer  
  AHO49116 (Get FASTA)   NCBI Sequence Viewer  
  AHO49117 (Get FASTA)   NCBI Sequence Viewer  
  BAA00080 (Get FASTA)   NCBI Sequence Viewer  
  BAD92287 (Get FASTA)   NCBI Sequence Viewer  
  BAF85625 (Get FASTA)   NCBI Sequence Viewer  
  BAG62125 (Get FASTA)   NCBI Sequence Viewer  
  CAH56859 (Get FASTA)   NCBI Sequence Viewer  
  CAJ33638 (Get FASTA)   NCBI Sequence Viewer  
  CBW44131 (Get FASTA)   NCBI Sequence Viewer  
  EAX08431 (Get FASTA)   NCBI Sequence Viewer  
  EAX08432 (Get FASTA)   NCBI Sequence Viewer  
  P17948 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_002010   ⟸   NM_002019
- Peptide Label: isoform 1 precursor
- UniProtKB: P17948 (UniProtKB/Swiss-Prot),   L7RSL3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001153502   ⟸   NM_001160030
- Peptide Label: isoform 3 precursor
- UniProtKB: P17948 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001153392   ⟸   NM_001159920
- Peptide Label: isoform 2 precursor
- UniProtKB: P17948 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001153503   ⟸   NM_001160031
- Peptide Label: isoform 4 precursor
- UniProtKB: P17948 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011533316   ⟸   XM_011535014
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_016875974   ⟸   XM_017020485
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000437631   ⟸   ENST00000541932
RefSeq Acc Id: ENSP00000437841   ⟸   ENST00000543394
RefSeq Acc Id: ENSP00000282397   ⟸   ENST00000282397
RefSeq Acc Id: ENSP00000491097   ⟸   ENST00000639477
RefSeq Acc Id: ENSP00000484039   ⟸   ENST00000615840
RefSeq Acc Id: ENSP00000484385   ⟸   ENST00000615611
RefSeq Acc Id: ENSP00000442630   ⟸   ENST00000539099
RefSeq Acc Id: ENSP00000484832   ⟸   ENST00000617835
RefSeq Acc Id: ENSP00000443311   ⟸   ENST00000540678
Protein Domains
Ig-like   Ig-like C2-type   Protein kinase

Promoters
RGD ID:6790729
Promoter ID:HG_KWN:17404
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   Jurkat,   Lymphoblastoid,   NB4
Transcripts:NM_001159920,   NM_001160030,   NM_001160031,   NM_002019,   UC001USD.2,   UC001USE.2
Position:
Human AssemblyChrPosition (strand)Source
Build 361327,966,301 - 27,967,342 (-)MPROMDB
RGD ID:7226117
Promoter ID:EPDNEW_H18804
Type:initiation region
Name:FLT1_2
Description:fms related tyrosine kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H18805  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381328,308,433 - 28,308,493EPDNEW
RGD ID:7226119
Promoter ID:EPDNEW_H18805
Type:initiation region
Name:FLT1_1
Description:fms related tyrosine kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H18804  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381328,495,128 - 28,495,188EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_002019.4(FLT1):c.2116+5070C>A single nucleotide variant Lung cancer [RCV000097817] Chr13:28379815 [GRCh38]
Chr13:28953952 [GRCh37]
Chr13:13q12.3
uncertain significance
GRCh38/hg38 13q12.11-12.3(chr13:18958091-31090460)x3 copy number gain See cases [RCV000053729] Chr13:18958091..31090460 [GRCh38]
Chr13:19532231..31664597 [GRCh37]
Chr13:18430231..30562597 [NCBI36]
Chr13:13q12.11-12.3
pathogenic
GRCh38/hg38 13q12.11-34(chr13:19837395-114327173)x3 copy number gain See cases [RCV000053731] Chr13:19837395..114327173 [GRCh38]
Chr13:20411535..115085141 [GRCh37]
Chr13:19309535..114110750 [NCBI36]
Chr13:13q12.11-34
pathogenic
GRCh38/hg38 13q11-34(chr13:18565048-114327173)x3 copy number gain See cases [RCV000053719] Chr13:18565048..114327173 [GRCh38]
Chr13:19139188..115085141 [GRCh37]
Chr13:18037188..114110750 [NCBI36]
Chr13:13q11-34
pathogenic
GRCh38/hg38 13q11-13.3(chr13:18676442-37656039)x3 copy number gain See cases [RCV000053721] Chr13:18676442..37656039 [GRCh38]
Chr13:19250582..38230176 [GRCh37]
Chr13:18148582..37128176 [NCBI36]
Chr13:13q11-13.3
pathogenic
GRCh38/hg38 13q11-34(chr13:18850545-114327173)x3 copy number gain See cases [RCV000053723] Chr13:18850545..114327173 [GRCh38]
Chr13:19296527..115085141 [GRCh37]
Chr13:18194527..114110750 [NCBI36]
Chr13:13q11-34
pathogenic
GRCh38/hg38 13q12.11-34(chr13:18946182-114304628)x3 copy number gain See cases [RCV000053726] Chr13:18946182..114304628 [GRCh38]
Chr13:19520322..115070103 [GRCh37]
Chr13:18418322..114088205 [NCBI36]
Chr13:13q12.11-34
pathogenic
NM_002019.4(FLT1):c.2827G>A (p.Glu943Lys) single nucleotide variant Malignant melanoma [RCV000062656] Chr13:28322916 [GRCh38]
Chr13:28897053 [GRCh37]
Chr13:27795053 [NCBI36]
Chr13:13q12.3
not provided
NM_001159920.1(FLT1):c.1634G>A (p.Gly545Glu) single nucleotide variant Malignant melanoma [RCV000062657] Chr13:28396986 [GRCh38]
Chr13:28971123 [GRCh37]
Chr13:27869123 [NCBI36]
Chr13:13q12.3
not provided
NM_002019.4(FLT1):c.3287-16A>C single nucleotide variant Carcinoma of colon [RCV000149489] Chr13:28317613 [GRCh38]
Chr13:28891750 [GRCh37]
Chr13:13q12.3
not provided
NM_002019.4(FLT1):c.3204T>C (p.Pro1068=) single nucleotide variant Carcinoma of colon [RCV000149490] Chr13:28319505 [GRCh38]
Chr13:28893642 [GRCh37]
Chr13:13q12.3
not provided
NM_002019.4(FLT1):c.3175-69A>T single nucleotide variant Carcinoma of colon [RCV000149491] Chr13:28319603 [GRCh38]
Chr13:28893740 [GRCh37]
Chr13:13q12.3
not provided
NM_002019.4(FLT1):c.3042_3043insA (p.Ser1015fs) insertion Carcinoma of colon [RCV000149492] Chr13:28322270..28322271 [GRCh38]
Chr13:28896407..28896408 [GRCh37]
Chr13:13q12.3
not provided
NM_002019.4(FLT1):c.2708-29A>C single nucleotide variant Carcinoma of colon [RCV000149493] Chr13:28327579 [GRCh38]
Chr13:28901716 [GRCh37]
Chr13:13q12.3
not provided
NM_002019.4(FLT1):c.2708-39G>C single nucleotide variant Carcinoma of colon [RCV000149494] Chr13:28327589 [GRCh38]
Chr13:28901726 [GRCh37]
Chr13:13q12.3
not provided
NM_002019.4(FLT1):c.2654_2655insA (p.Gly886fs) insertion Carcinoma of colon [RCV000149495] Chr13:28329667..28329668 [GRCh38]
Chr13:28903804..28903805 [GRCh37]
Chr13:13q12.3
not provided
NM_002019.4(FLT1):c.2901G>A (p.Ala967=) single nucleotide variant Carcinoma of colon [RCV000149496] Chr13:28322842 [GRCh38]
Chr13:28896979 [GRCh37]
Chr13:13q12.3
not provided
NM_002019.4(FLT1):c.2871A>T (p.Leu957=) single nucleotide variant Carcinoma of colon [RCV000149497] Chr13:28322872 [GRCh38]
Chr13:28897009 [GRCh37]
Chr13:13q12.3
not provided
GRCh38/hg38 13q12.11-34(chr13:19833130-114298614)x3 copy number gain See cases [RCV000134104] Chr13:19833130..114298614 [GRCh38]
Chr13:20407270..115064089 [GRCh37]
Chr13:19305270..114082191 [NCBI36]
Chr13:13q12.11-34
pathogenic
GRCh38/hg38 13q12.13-12.3(chr13:26965244-30097858)x3 copy number gain See cases [RCV000135283] Chr13:26965244..30097858 [GRCh38]
Chr13:27539381..30671995 [GRCh37]
Chr13:26437381..29569995 [NCBI36]
Chr13:13q12.13-12.3
likely pathogenic
GRCh38/hg38 13q11-34(chr13:18445862-114327173)x1 copy number loss See cases [RCV000135610] Chr13:18445862..114327173 [GRCh38]
Chr13:19020001..115085141 [GRCh37]
Chr13:10098739..114110750 [NCBI36]
Chr13:13q11-34
pathogenic
GRCh38/hg38 13q12.11-14.11(chr13:19671934-40914767)x3 copy number gain See cases [RCV000137892] Chr13:19671934..40914767 [GRCh38]
Chr13:20246074..41488903 [GRCh37]
Chr13:19144074..40386903 [NCBI36]
Chr13:13q12.11-14.11
pathogenic
GRCh38/hg38 13q12.11-34(chr13:19833130-114327106)x3 copy number gain See cases [RCV000139078] Chr13:19833130..114327106 [GRCh38]
Chr13:20407270..115085141 [GRCh37]
Chr13:19305270..114110683 [NCBI36]
Chr13:13q12.11-34
pathogenic
GRCh38/hg38 13q11-34(chr13:18456040-114340285)x3 copy number gain See cases [RCV000140004] Chr13:18456040..114340285 [GRCh38]
Chr13:19030180..115105760 [GRCh37]
Chr13:17928180..114123862 [NCBI36]
Chr13:13q11-34
pathogenic
GRCh38/hg38 13q11-13.2(chr13:18862146-33577351)x3 copy number gain See cases [RCV000141867] Chr13:18862146..33577351 [GRCh38]
Chr13:19436286..34151488 [GRCh37]
Chr13:18334286..33049488 [NCBI36]
Chr13:13q11-13.2
pathogenic
GRCh38/hg38 13q12.11-34(chr13:19671934-114340331)x3 copy number gain See cases [RCV000142924] Chr13:19671934..114340331 [GRCh38]
Chr13:20246074..115085141 [GRCh37]
Chr13:19144074..114123908 [NCBI36]
Chr13:13q12.11-34
pathogenic
GRCh38/hg38 13q11-34(chr13:18862146-114342258)x3 copy number gain See cases [RCV000143462] Chr13:18862146..114342258 [GRCh38]
Chr13:19436286..115107733 [GRCh37]
Chr13:18334286..114125835 [NCBI36]
Chr13:13q11-34
pathogenic
GRCh38/hg38 13q12.11-34(chr13:19837395-114327173)x3 copy number gain See cases [RCV000148126] Chr13:19837395..114327173 [GRCh38]
Chr13:20411535..115085141 [GRCh37]
Chr13:19309535..114110750 [NCBI36]
Chr13:13q12.11-34
pathogenic
NM_002019.4(FLT1):c.3329G>C (p.Cys1110Ser) single nucleotide variant Carcinoma of colon [RCV000162254] Chr13:28317555 [GRCh38]
Chr13:28891692 [GRCh37]
Chr13:13q12.3
not provided
NM_002019.4(FLT1):c.2439_2466del (p.Tyr815fs) deletion Carcinoma of colon [RCV000186550] Chr13:28339190..28339217 [GRCh38]
Chr13:28913327..28913354 [GRCh37]
Chr13:13q12.3
uncertain significance
GRCh37/hg19 13q12.11-34(chr13:19571503-115092569)x3 copy number gain See cases [RCV000240150] Chr13:19571503..115092569 [GRCh37]
Chr13:13q12.11-34
pathogenic
GRCh37/hg19 13q12.11-34(chr13:19571503-115092510) copy number gain See cases [RCV000449142] Chr13:19571503..115092510 [GRCh37]
Chr13:13q12.11-34
pathogenic
GRCh37/hg19 13q11-34(chr13:19436286-115107733)x3 copy number gain See cases [RCV000445886] Chr13:19436286..115107733 [GRCh37]
Chr13:13q11-34
pathogenic
GRCh37/hg19 13q11-34(chr13:19436287-115107733) copy number gain See cases [RCV000510405] Chr13:19436287..115107733 [GRCh37]
Chr13:13q11-34
pathogenic
GRCh37/hg19 13q11-34(chr13:19436287-115107733)x3 copy number gain See cases [RCV000511880] Chr13:19436287..115107733 [GRCh37]
Chr13:13q11-34
pathogenic
GRCh37/hg19 13q12.12-13.2(chr13:24080918-34361992)x1 copy number loss PARP Inhibitor response [RCV000626443] Chr13:24080918..34361992 [GRCh37]
Chr13:13q12.12-13.2
drug response
GRCh37/hg19 13q12.2-12.3(chr13:28152002-29117192)x3 copy number gain See cases [RCV000512521] Chr13:28152002..29117192 [GRCh37]
Chr13:13q12.2-12.3
uncertain significance
GRCh37/hg19 13q11-22.1(chr13:19436286-74045459)x3 copy number gain not provided [RCV000683572] Chr13:19436286..74045459 [GRCh37]
Chr13:13q11-22.1
pathogenic
GRCh37/hg19 13q11-34(chr13:19058717-115103529)x3 copy number gain not provided [RCV000738115] Chr13:19058717..115103529 [GRCh37]
Chr13:13q11-34
pathogenic
GRCh37/hg19 13q12.3(chr13:28988795-29451698)x3 copy number gain not provided [RCV000738147] Chr13:28988795..29451698 [GRCh37]
Chr13:13q12.3
benign
GRCh37/hg19 13q11-34(chr13:19031237-115107157)x3 copy number gain not provided [RCV000750643] Chr13:19031237..115107157 [GRCh37]
Chr13:13q11-34
pathogenic
NM_002019.4(FLT1):c.321C>T (p.Cys107=) single nucleotide variant not provided [RCV000901557] Chr13:28466970 [GRCh38]
Chr13:29041107 [GRCh37]
Chr13:13q12.3
likely benign
NM_002019.4(FLT1):c.2382C>T (p.Tyr794=) single nucleotide variant not provided [RCV000880653] Chr13:28339274 [GRCh38]
Chr13:28913411 [GRCh37]
Chr13:13q12.3
benign
NM_002019.4(FLT1):c.1474C>T (p.Leu492=) single nucleotide variant not provided [RCV000881711] Chr13:28405857 [GRCh38]
Chr13:28979994 [GRCh37]
Chr13:13q12.3
benign
NM_002019.4(FLT1):c.3175-10C>T single nucleotide variant not provided [RCV000906404] Chr13:28319544 [GRCh38]
Chr13:28893681 [GRCh37]
Chr13:13q12.3
benign
NM_002019.4(FLT1):c.1095G>A (p.Pro365=) single nucleotide variant not provided [RCV000905305] Chr13:28430061 [GRCh38]
Chr13:29004198 [GRCh37]
Chr13:13q12.3
benign
NM_002019.4(FLT1):c.2061C>T (p.Val687=) single nucleotide variant not provided [RCV000947518] Chr13:28384940 [GRCh38]
Chr13:28959077 [GRCh37]
Chr13:13q12.3
benign
NM_002019.4(FLT1):c.16G>A (p.Asp6Asn) single nucleotide variant not provided [RCV000901419] Chr13:28494828 [GRCh38]
Chr13:29068965 [GRCh37]
Chr13:13q12.3
benign
NM_002019.4(FLT1):c.1284C>A (p.Pro428=) single nucleotide variant not provided [RCV000943502] Chr13:28427311 [GRCh38]
Chr13:29001448 [GRCh37]
Chr13:13q12.3
likely benign
NM_002019.4(FLT1):c.3969G>A (p.Pro1323=) single nucleotide variant not provided [RCV000885484] Chr13:28303215 [GRCh38]
Chr13:28877352 [GRCh37]
Chr13:13q12.3
likely benign
NM_002019.4(FLT1):c.780G>A (p.Thr260=) single nucleotide variant not provided [RCV000893439] Chr13:28433852 [GRCh38]
Chr13:29007989 [GRCh37]
Chr13:13q12.3
benign
NM_002019.4(FLT1):c.2812A>G (p.Met938Val) single nucleotide variant not provided [RCV000958668] Chr13:28322931 [GRCh38]
Chr13:28897068 [GRCh37]
Chr13:13q12.3
likely benign
GRCh37/hg19 13q11-34(chr13:19436286-115107733)x3 copy number gain not provided [RCV000849129] Chr13:19436286..115107733 [GRCh37]
Chr13:13q11-34
pathogenic
NM_002019.4(FLT1):c.405C>T (p.Phe135=) single nucleotide variant not provided [RCV000892299] Chr13:28438329 [GRCh38]
Chr13:29012466 [GRCh37]
Chr13:13q12.3
benign
NM_002019.4(FLT1):c.1644A>G (p.Ile548Met) single nucleotide variant not provided [RCV000885485] Chr13:28396976 [GRCh38]
Chr13:28971113 [GRCh37]
Chr13:13q12.3
likely benign
NM_002019.4(FLT1):c.1701G>A (p.Pro567=) single nucleotide variant not provided [RCV000925971] Chr13:28390064 [GRCh38]
Chr13:28964201 [GRCh37]
Chr13:13q12.3
likely benign
NM_002019.4(FLT1):c.1302C>T (p.Ala434=) single nucleotide variant not provided [RCV000954876] Chr13:28427293 [GRCh38]
Chr13:29001430 [GRCh37]
Chr13:13q12.3
benign
NM_002019.4(FLT1):c.3602C>T (p.Pro1201Leu) single nucleotide variant not provided [RCV000885710] Chr13:28311623 [GRCh38]
Chr13:28885760 [GRCh37]
Chr13:13q12.3
likely benign
NM_002019.4(FLT1):c.3558T>C (p.Thr1186=) single nucleotide variant not provided [RCV000889020] Chr13:28311667 [GRCh38]
Chr13:28885804 [GRCh37]
Chr13:13q12.3
likely benign
NM_002019.4(FLT1):c.3552C>T (p.Tyr1184=) single nucleotide variant not provided [RCV000955476] Chr13:28311673 [GRCh38]
Chr13:28885810 [GRCh37]
Chr13:13q12.3
likely benign
NM_002019.4(FLT1):c.3054C>T (p.Cys1018=) single nucleotide variant not provided [RCV000933769] Chr13:28321583 [GRCh38]
Chr13:28895720 [GRCh37]
Chr13:13q12.3
likely benign
GRCh37/hg19 13q12.12-12.3(chr13:23775339-30534624)x3 copy number gain not provided [RCV001258538] Chr13:23775339..30534624 [GRCh37]
Chr13:13q12.12-12.3
likely pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:3763 AgrOrtholog
COSMIC FLT1 COSMIC
Ensembl Genes ENSG00000102755 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000282397 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000437631 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000437841 UniProtKB/Swiss-Prot
  ENSP00000442630 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000443311 UniProtKB/TrEMBL
  ENSP00000484039 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000484385 UniProtKB/TrEMBL
  ENSP00000484832 UniProtKB/TrEMBL
  ENSP00000491097 UniProtKB/TrEMBL
Ensembl Transcript ENST00000282397 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000539099 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000540678 UniProtKB/TrEMBL
  ENST00000541932 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000543394 UniProtKB/Swiss-Prot
  ENST00000615611 UniProtKB/TrEMBL
  ENST00000615840 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000617835 UniProtKB/TrEMBL
  ENST00000639477 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000102755 GTEx
HGNC ID HGNC:3763 ENTREZGENE
Human Proteome Map FLT1 Human Proteome Map
InterPro Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Immunoglobulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_kinase_rcpt_3_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VEGFR-2_TMD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VEGFR1_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:2321 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 2321 ENTREZGENE
OMIM 165070 OMIM
Pfam I-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00047 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VEGFR-2_TMD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB FLT1 RGD, PharmGKB
PRINTS TYRKINASE UniProtKB/TrEMBL
  VEGFRECEPTR1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_III UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART IGc2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IGv UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TyrKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1W2PNW4_HUMAN UniProtKB/TrEMBL
  B1AC84_HUMAN UniProtKB/TrEMBL
  H9N1E7_HUMAN UniProtKB/TrEMBL
  H9N1E8_HUMAN UniProtKB/TrEMBL
  L7RSL3 ENTREZGENE, UniProtKB/TrEMBL
  P17948 ENTREZGENE
  V9Q458_HUMAN UniProtKB/TrEMBL
  V9Q5H8_HUMAN UniProtKB/TrEMBL
  VGFR1_HUMAN UniProtKB/Swiss-Prot
  X2C8T1_HUMAN UniProtKB/TrEMBL
  X2CBY1_HUMAN UniProtKB/TrEMBL
  X2QEJ0_HUMAN UniProtKB/TrEMBL
  X2QIK8_HUMAN UniProtKB/TrEMBL
UniProt Secondary A3E342 UniProtKB/Swiss-Prot
  A3E344 UniProtKB/Swiss-Prot
  A8KA71 UniProtKB/Swiss-Prot
  B0LPF1 UniProtKB/Swiss-Prot
  B2BF46 UniProtKB/Swiss-Prot
  B2BF47 UniProtKB/Swiss-Prot
  B2BF48 UniProtKB/Swiss-Prot
  B3FR89 UniProtKB/Swiss-Prot
  B5A923 UniProtKB/Swiss-Prot
  F5H5L6 UniProtKB/Swiss-Prot
  O60722 UniProtKB/Swiss-Prot
  P16057 UniProtKB/Swiss-Prot
  Q12954 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-12-10 FLT1  fms related receptor tyrosine kinase 1  FLT1  fms related tyrosine kinase 1  Symbol and/or name change 5135510 APPROVED
2016-01-19 FLT1  fms related tyrosine kinase 1  FLT1  fms-related tyrosine kinase 1  Symbol and/or name change 5135510 APPROVED
2012-11-28 FLT1  fms-related tyrosine kinase 1  FLT1  fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)  Symbol and/or name change 5135510 APPROVED