ANXA1 (annexin A1) - Rat Genome Database

Name: ANXA1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: ANXA1 (annexin A1) Pan paniscus

Analyze

Symbol:

ANXA1

Name:

annexin A1

RGD ID:

11937773

Description:

ENCODES a protein that exhibits calcium ion binding (ortholog); calcium-dependent phospholipid binding (ortholog); calcium-dependent protein binding (ortholog); INVOLVED IN actin cytoskeleton reorganization (ortholog); alpha-beta T cell differentiation (ortholog); arachidonic acid secretion (ortholog); PARTICIPATES IN cyclooxygenase mediated pathway of arachidonic acid metabolism; ASSOCIATED WITH acute kidney failure (ortholog); Animal Mammary Neoplasms (ortholog); asthma (ortholog); FOUND IN actin filament (ortholog); apical plasma membrane (ortholog); cell surface (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

RGD Orthologs

Human

Mouse

Rat

Chinchilla

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	ANXA1 (annexin A1)	NCBI	Ortholog
Mus musculus (house mouse):	Anxa1 (annexin A1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Anxa1 (annexin A1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Anxa1 (annexin A1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	ANXA1 (annexin A1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Anxa1 (annexin A1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	ANXA1 (annexin A1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	ANXA1 (annexin A1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Anxa1 (annexin A1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	9	71,930,148 - 71,948,779 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	71,929,728 - 71,948,779 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	9	51,647,404 - 51,665,990 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute kidney failure (ISO)

Animal Mammary Neoplasms (ISO)

asthma (ISO)

Blister (ISO)

brain ischemia (ISO)

Breast Neoplasms (ISO)

carcinoma (ISO)

cataract (ISO)

Cerebral Hemorrhage (ISO)

cerebral infarction (ISO)

colitis (ISO)

contact dermatitis (ISO)

COVID-19 (ISO)

Craniofacial Abnormalities (ISO)

Delayed Hypersensitivity (ISO)

Discoid Lupus Erythematosus (ISO)

dry eye syndrome (ISO)

ductal carcinoma in situ (ISO)

encephalitis (ISO)

esophagus squamous cell carcinoma (ISO)

Experimental Arthritis (ISO)

Experimental Autoimmune Encephalomyelitis (ISO)

Experimental Autoimmune Neuritis (ISO)

Experimental Diabetes Mellitus (ISO)

Experimental Liver Cirrhosis (ISO)

Hyperalgesia (ISO)

hypertension (ISO)

hyperthyroidism (ISO)

hypothyroidism (ISO)

Inflammation (ISO)

invasive ductal carcinoma (ISO)

ischemia (ISO)

keratosis follicularis (ISO)

kidney disease (ISO)

Kidney Reperfusion Injury (ISO)

lung adenocarcinoma (ISO)

Lymphatic Metastasis (ISO)

malignant astrocytoma (ISO)

Mammary Neoplasms, Experimental (ISO)

Mouth Neoplasms (ISO)

Myocardial Reperfusion Injury (ISO)

Nasal Polyps (ISO)

Neoplasm Invasiveness (ISO)

Neoplasm Metastasis (ISO)

Ocular Toxoplasmosis (ISO)

pancreatic cancer (ISO)

paranasal sinus benign neoplasm (ISO)

pleurisy (ISO)

Prostatic Neoplasms (ISO)

psoriasis (ISO)

pulmonary fibrosis (ISO)

renal cell carcinoma (ISO)

Rhinosinusitis (ISO)

seborrheic keratosis (ISO)

Skin Neoplasms (ISO)

Spinal Cord Injuries (ISO)

squamous cell carcinoma (ISO)

stomach cancer (ISO)

stomach disease (ISO)

transitional cell carcinoma (ISO)

uveitis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

actin cytoskeleton reorganization (ISO)

alpha-beta T cell differentiation (ISO)

arachidonic acid secretion (ISO)

cell surface receptor signaling pathway (ISO)

cellular response to glucocorticoid stimulus (ISO)

cellular response to hydrogen peroxide (ISO)

cellular response to vascular endothelial growth factor stimulus (ISO)

DNA duplex unwinding (ISO)

endocrine pancreas development (ISO)

estrous cycle (ISO)

G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger (ISO)

gliogenesis (ISO)

granulocyte chemotaxis (ISO)

hepatocyte differentiation (ISO)

inflammatory response (ISO)

insulin secretion (ISO)

keratinocyte differentiation (ISO)

monocyte chemotaxis (ISO)

myoblast migration involved in skeletal muscle regeneration (ISO)

negative regulation of exocytosis (ISO)

negative regulation of interleukin-8 production (ISO)

negative regulation of phospholipase A2 activity (ISO)

negative regulation of protein secretion (ISO)

negative regulation of T-helper 2 cell differentiation (ISO)

neutrophil clearance (ISO)

neutrophil homeostasis (ISO)

peptide cross-linking (ISO)

phagocytosis (ISO)

positive regulation of apoptotic process (ISO)

positive regulation of cell migration involved in sprouting angiogenesis (ISO)

positive regulation of G1/S transition of mitotic cell cycle (ISO)

positive regulation of interleukin-2 production (ISO)

positive regulation of neutrophil apoptotic process (ISO)

positive regulation of prostaglandin biosynthetic process (ISO)

positive regulation of T cell proliferation (ISO)

positive regulation of T-helper 1 cell differentiation (ISO)

positive regulation of vesicle fusion (ISO)

positive regulation of wound healing (ISO)

prolactin secretion (ISO)

prostate gland development (ISO)

regulation of cell population proliferation (ISO)

regulation of cell shape (ISO)

regulation of hormone secretion (ISO)

regulation of inflammatory response (ISO)

regulation of interleukin-1 production (ISO)

regulation of leukocyte migration (ISO)

response to corticosteroid (ISO)

response to drug (ISO)

response to estradiol (ISO)

response to glucocorticoid (ISO)

response to hormone (ISO)

response to interleukin-1 (ISO)

response to organic cyclic compound (ISO)

response to peptide hormone (ISO)

response to X-ray (ISO)

signal transduction (ISO)

Cellular Component

actin filament (ISO)

apical plasma membrane (ISO)

cell surface (ISO)

cornified envelope (ISO)

cytoplasm (ISO)

cytosol (ISO)

early endosome membrane (ISO)

endosome (ISO)

exocytic vesicle (ISO)

extracellular exosome (ISO)

extracellular space (ISO)

extrinsic component of endosome membrane (ISO)

extrinsic component of external side of plasma membrane (ISO)

extrinsic component of membrane (ISO)

lateral plasma membrane (ISO)

mast cell granule (ISO)

mitochondrial membrane (ISO)

motile cilium (ISO)

nucleoplasm (ISO)

nucleus (ISO)

plasma membrane (ISO)

protein-containing complex (ISO)

sarcolemma (ISO)

synaptic membrane (ISO)

Molecular Function

calcium ion binding (ISO)

calcium-dependent phospholipid binding (ISO)

calcium-dependent protein binding (ISO)

DNA/DNA annealing activity (ISO)

double-stranded DNA helicase activity (ISO)

identical protein binding (ISO)

phospholipase A2 inhibitor activity (ISO)

phospholipid binding (ISO)

protein binding (ISO)

single-stranded DNA binding (ISO)

single-stranded RNA binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

cyclooxygenase mediated pathway of arachidonic acid metabolism (ISO)

References

Genomics

Comparative Map Data

ANXA1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	9	71,930,148 - 71,948,779 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	71,929,728 - 71,948,779 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	9	51,647,404 - 51,665,990 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

ANXA1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	9	73,151,865 - 73,170,393 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	9	73,151,865 - 73,170,393 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	9	75,766,781 - 75,785,309 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	74,956,601 - 74,975,127 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	9	72,996,334 - 73,014,861	NCBI
Celera	9	46,339,417 - 46,357,944 (+)	NCBI
Cytogenetic Map	9	q21.13	ENTREZGENE
HuRef	9	45,589,147 - 45,607,684 (+)	NCBI		HuRef
CHM1_1	9	75,913,496 - 75,932,176 (+)	NCBI		CHM1_1

Anxa1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	20,350,798 - 20,368,035 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	19	20,350,792 - 20,368,308 (-)	Ensembl
GRCm38	19	20,373,434 - 20,390,671 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	20,373,428 - 20,390,944 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	20,447,924 - 20,465,161 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	19	20,440,455 - 20,457,696 (-)	NCBI			mm8
Celera	19	21,098,423 - 21,115,607 (-)	NCBI		Celera
Cytogenetic Map	19	B	NCBI
cM Map	19	13.83	NCBI

Anxa1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	217,861,175 - 217,877,205 (-)	NCBI
Rnor_6.0 Ensembl	1	237,893,966 - 237,910,012 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	1	237,893,983 - 237,910,002 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	1	245,192,875 - 245,220,057 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	223,478,436 - 223,494,455 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	1	223,642,460 - 223,658,478 (-)	NCBI
Celera	1	215,138,950 - 215,154,969 (-)	NCBI		Celera
Cytogenetic Map	1	q51	NCBI

Anxa1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955512	5,686,508 - 5,703,645 (-)	NCBI	ChiLan1.0	ChiLan1.0

ANXA1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	1	84,744,163 - 84,763,011 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	1	84,744,159 - 84,763,011 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Anxa1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936503	9,124,314 - 9,142,372 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ANXA1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	226,414,307 - 226,432,287 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	226,414,200 - 226,431,963 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	252,989,694 - 253,007,485 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ANXA1
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	84,207,818 - 84,226,438 (+)	NCBI
ChlSab1.1 Ensembl	12	84,207,820 - 84,226,562 (+)	Ensembl

Anxa1
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624811	765,338 - 782,203 (+)	NCBI

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003822193	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	SSBP01000089	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSPPAT00000037494 ⟹ ENSPPAP00000014806

RefSeq Status:

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	9	71,929,728 - 71,948,779 (+)	Ensembl

RefSeq Acc Id:

XM_003822193 ⟹ XP_003822241

RefSeq Status:

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1	9	71,930,148 - 71,948,779 (+)	NCBI
Mhudiblu_PPA_v0	9	51,647,404 - 51,665,990 (-)	NCBI

Sequence:

show sequence

ACTTGTTTCACTTTGTTTTTGGACATAGCTGAGCCATGTACTTCAAACAGAAGACAGCCAATTA
CTAACTTCTGGTTGCTAGGTGTGGCTTCCTTTAAAATCCTATAAAATCAGAAGCCCAAGTCTCC
ACTGCCAGTGTGAAATCTTCAGAGAAGAATTTCTCTTTAGTTCTTTGCAAGAAGGTAGAGATAA
AGACACTTTTTCAAAAATGGCAATGGTATCAGAATTCCTCAAGCAGGCCTGGTTTATTGAAAAT
GAAGAGCAGGAATATGTTCAAACTGTGAAGTCATCCAAAGGTGGTCCCGGATCAGCGGTGAGCC
CCTATCCTACCTTCAATCCATCCTCGGATGTCGCTGCCTTGCACAAGGCCATAATGGTTAAAGG
TGTGGATGAAGCAACCATCATTGACATTCTAACTAAGCGAAACAATGCACAGCGTCAACAGATC
AAAGCAGCATATCTCCAGGAAACAGGAAAGCCCCTGGATGAAACACTGAAGAAAGCCCTTACAG
GTCACCTTGAGGAGGTTGTTTTAGCTCTGCTAAAAACTCCAGCACAATTTGATGCTGATGAACT
TCGTGCTGCCATGAAGGGCCTTGGAACTGATGAAGATACTCTAATTGAGATTTTGGCATCAAGA
ACTAACAAAGAAATCAGAGACATTAACAGGGTCTACAGAGAGGAACTGAAGAGAGATCTGGCCA
AAGACATAACCTCAGACACATCTGGAGATTTTCGGAACGCTTTGCTTTCTCTTGCTAAGGGTGA
CCGATCTGAGGACTTTGGTGTGAATGAAGACTTGGCTGATTCAGATGCCAGGGCCTTGTATGAA
GCAGGAGAAAGGAGAAAGGGGACAGACGTAAACGTGTTCAATACCATCCTTACCACCAGAAGCT
ATCCACAACTTCGCAGAGTGTTTCAGAAATACACCAAGTACAGTAAGCATGACATGAACAAAGT
TCTGGACCTGGAGTTGAAAGGTGACATTGAGAAATGCCTCACAGCTATCGTGAAGTGCGCCACA
AGCAAACCAGCTTTCTTTGCAGAGAAGCTTCATCAAGCCATGAAAGGTGTTGGAACTCGCCATA
AGGCATTGATCAGGATTATGGTTTCCCGTTCTGAAATTGACATGAATGATATCAAAGCATTCTA
TCAGAAGATGTATGGTATCTCCCTTTGCCAAGCCATCCTGGATGAAACCAAAGGAGATTATGAA
AAAATCCTGGTGGCTCTTTGTGGAGGAAACTAAACATTCCCTTGATGGTCTCAAGCTATGATCA
GAAGACTTTAATTATATATTTTCATCCTATAAGCTTAAATAGGAAAGTTTCTTCAACAGGATTA
CAGTGTAGCTACCTACATGCTGAAAAATATAGCCTTTAAATCATTTTTATATTATAACTCTGTA
TAATAGAGATAAGTCCATTTTTAAAAAATGTTTTCCCCAAACCATAAAACCCTATACAAGTTGT
TCTAGTAACAATACATGAGAAAGATGTCTATGTAGCTGAAAATAAAATGACGTCACAAGACAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003822241	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

XP_003822241 ⟸ XM_003822193

- Sequence:

show sequence

MAMVSEFLKQAWFIENEEQEYVQTVKSSKGGPGSAVSPYPTFNPSSDVAALHKAIMVKGVDEAT
IIDILTKRNNAQRQQIKAAYLQETGKPLDETLKKALTGHLEEVVLALLKTPAQFDADELRAAMK
GLGTDEDTLIEILASRTNKEIRDINRVYREELKRDLAKDITSDTSGDFRNALLSLAKGDRSEDF
GVNEDLADSDARALYEAGERRKGTDVNVFNTILTTRSYPQLRRVFQKYTKYSKHDMNKVLDLEL
KGDIEKCLTAIVKCATSKPAFFAEKLHQAMKGVGTRHKALIRIMVSRSEIDMNDIKAFYQKMYG
ISLCQAILDETKGDYEKILVALCGGN

hide sequence

RefSeq Acc Id:

ENSPPAP00000014806 ⟸ ENSPPAT00000037494

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000030576	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSPPAP00000014806	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000037494	UniProtKB/TrEMBL
Gene3D-CATH	1.10.220.10	UniProtKB/TrEMBL
InterPro	Annexin	UniProtKB/TrEMBL
	Annexin_repeat	UniProtKB/TrEMBL
	Annexin_repeat_CS	UniProtKB/TrEMBL
	Annexin_sf	UniProtKB/TrEMBL
	ANX1	UniProtKB/TrEMBL
KEGG Report	pps:100994302	UniProtKB/TrEMBL
NCBI Gene	ANXA1	ENTREZGENE
PANTHER	PTHR10502:SF17	UniProtKB/TrEMBL
Pfam	Annexin	UniProtKB/TrEMBL
PRINTS	ANNEXIN	UniProtKB/TrEMBL
	ANNEXINI	UniProtKB/TrEMBL
PROSITE	ANNEXIN	UniProtKB/TrEMBL
	ANNEXIN_2	UniProtKB/TrEMBL
SMART	ANX	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47874	UniProtKB/TrEMBL
UniProt	A0A2R9AD24_PANPA	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

RGD Manual Annotations