ANXA1 (annexin A1) - Rat Genome Database
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Gene: ANXA1 (annexin A1) Pan paniscus
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Symbol: ANXA1
Name: annexin A1
RGD ID: 11937773
Description: ENCODES a protein that exhibits calcium ion binding (ortholog); calcium-dependent phospholipid binding (ortholog); calcium-dependent protein binding (ortholog); INVOLVED IN actin cytoskeleton reorganization (ortholog); alpha-beta T cell differentiation (ortholog); arachidonic acid secretion (ortholog); PARTICIPATES IN cyclooxygenase mediated pathway of arachidonic acid metabolism; ASSOCIATED WITH acute kidney failure (ortholog); Animal Mammary Neoplasms (ortholog); asthma (ortholog); FOUND IN actin filament (ortholog); apical plasma membrane (ortholog); cell surface (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1971,930,148 - 71,948,779 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl971,929,728 - 71,948,779 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0951,647,404 - 51,665,990 (-)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Animal Mammary Neoplasms  (ISO)
asthma  (ISO)
Blister  (ISO)
brain ischemia  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
cataract  (ISO)
Cerebral Hemorrhage  (ISO)
cerebral infarction  (ISO)
colitis  (ISO)
contact dermatitis  (ISO)
COVID-19  (ISO)
Craniofacial Abnormalities  (ISO)
Delayed Hypersensitivity  (ISO)
Discoid Lupus Erythematosus  (ISO)
dry eye syndrome  (ISO)
ductal carcinoma in situ  (ISO)
encephalitis  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Hyperalgesia  (ISO)
hypertension  (ISO)
hyperthyroidism  (ISO)
hypothyroidism  (ISO)
Inflammation  (ISO)
invasive ductal carcinoma  (ISO)
ischemia  (ISO)
keratosis follicularis  (ISO)
kidney disease  (ISO)
Kidney Reperfusion Injury  (ISO)
lung adenocarcinoma  (ISO)
Lymphatic Metastasis  (ISO)
malignant astrocytoma  (ISO)
Mammary Neoplasms, Experimental  (ISO)
Mouth Neoplasms  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nasal Polyps  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Ocular Toxoplasmosis  (ISO)
pancreatic cancer  (ISO)
paranasal sinus benign neoplasm  (ISO)
pleurisy  (ISO)
Prostatic Neoplasms  (ISO)
psoriasis  (ISO)
pulmonary fibrosis  (ISO)
renal cell carcinoma  (ISO)
Rhinosinusitis  (ISO)
seborrheic keratosis  (ISO)
Skin Neoplasms  (ISO)
Spinal Cord Injuries  (ISO)
squamous cell carcinoma  (ISO)
stomach cancer  (ISO)
stomach disease  (ISO)
transitional cell carcinoma  (ISO)
uveitis  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton reorganization  (ISO)
alpha-beta T cell differentiation  (ISO)
arachidonic acid secretion  (ISO)
cell surface receptor signaling pathway  (ISO)
cellular response to glucocorticoid stimulus  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to vascular endothelial growth factor stimulus  (ISO)
DNA duplex unwinding  (ISO)
endocrine pancreas development  (ISO)
estrous cycle  (ISO)
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  (ISO)
gliogenesis  (ISO)
granulocyte chemotaxis  (ISO)
hepatocyte differentiation  (ISO)
inflammatory response  (ISO)
insulin secretion  (ISO)
keratinocyte differentiation  (ISO)
monocyte chemotaxis  (ISO)
myoblast migration involved in skeletal muscle regeneration  (ISO)
negative regulation of exocytosis  (ISO)
negative regulation of interleukin-8 production  (ISO)
negative regulation of phospholipase A2 activity  (ISO)
negative regulation of protein secretion  (ISO)
negative regulation of T-helper 2 cell differentiation  (ISO)
neutrophil clearance  (ISO)
neutrophil homeostasis  (ISO)
peptide cross-linking  (ISO)
phagocytosis  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of cell migration involved in sprouting angiogenesis  (ISO)
positive regulation of G1/S transition of mitotic cell cycle  (ISO)
positive regulation of interleukin-2 production  (ISO)
positive regulation of neutrophil apoptotic process  (ISO)
positive regulation of prostaglandin biosynthetic process  (ISO)
positive regulation of T cell proliferation  (ISO)
positive regulation of T-helper 1 cell differentiation  (ISO)
positive regulation of vesicle fusion  (ISO)
positive regulation of wound healing  (ISO)
prolactin secretion  (ISO)
prostate gland development  (ISO)
regulation of cell population proliferation  (ISO)
regulation of cell shape  (ISO)
regulation of hormone secretion  (ISO)
regulation of inflammatory response  (ISO)
regulation of interleukin-1 production  (ISO)
regulation of leukocyte migration  (ISO)
response to corticosteroid  (ISO)
response to drug  (ISO)
response to estradiol  (ISO)
response to glucocorticoid  (ISO)
response to hormone  (ISO)
response to interleukin-1  (ISO)
response to organic cyclic compound  (ISO)
response to peptide hormone  (ISO)
response to X-ray  (ISO)
signal transduction  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
ANXA1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1971,930,148 - 71,948,779 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl971,929,728 - 71,948,779 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0951,647,404 - 51,665,990 (-)NCBIMhudiblu_PPA_v0panPan3
ANXA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl973,151,865 - 73,170,393 (+)EnsemblGRCh38hg38GRCh38
GRCh38973,151,865 - 73,170,393 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37975,766,781 - 75,785,309 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36974,956,601 - 74,975,127 (+)NCBINCBI36hg18NCBI36
Build 34972,996,334 - 73,014,861NCBI
Celera946,339,417 - 46,357,944 (+)NCBI
Cytogenetic Map9q21.13ENTREZGENE
HuRef945,589,147 - 45,607,684 (+)NCBIHuRef
CHM1_1975,913,496 - 75,932,176 (+)NCBICHM1_1
Anxa1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391920,350,798 - 20,368,035 (-)NCBIGRCm39mm39
GRCm39 Ensembl1920,350,792 - 20,368,308 (-)Ensembl
GRCm381920,373,434 - 20,390,671 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1920,373,428 - 20,390,944 (-)EnsemblGRCm38mm10GRCm38
MGSCv371920,447,924 - 20,465,161 (-)NCBIGRCm37mm9NCBIm37
MGSCv361920,440,455 - 20,457,696 (-)NCBImm8
Celera1921,098,423 - 21,115,607 (-)NCBICelera
Cytogenetic Map19BNCBI
cM Map1913.83NCBI
Anxa1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21217,861,175 - 217,877,205 (-)NCBI
Rnor_6.0 Ensembl1237,893,966 - 237,910,012 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01237,893,983 - 237,910,002 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01245,192,875 - 245,220,057 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41223,478,436 - 223,494,455 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11223,642,460 - 223,658,478 (-)NCBI
Celera1215,138,950 - 215,154,969 (-)NCBICelera
Cytogenetic Map1q51NCBI
Anxa1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555125,686,508 - 5,703,645 (-)NCBIChiLan1.0ChiLan1.0
ANXA1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl184,744,163 - 84,763,011 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1184,744,159 - 84,763,011 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Anxa1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365039,124,314 - 9,142,372 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ANXA1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1226,414,307 - 226,432,287 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11226,414,200 - 226,431,963 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21252,989,694 - 253,007,485 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ANXA1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11284,207,818 - 84,226,438 (+)NCBI
ChlSab1.1 Ensembl1284,207,820 - 84,226,562 (+)Ensembl
Anxa1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624811765,338 - 782,203 (+)NCBI


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003822193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide SSBP01000089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSPPAT00000037494   ⟹   ENSPPAP00000014806
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl971,929,728 - 71,948,779 (+)Ensembl
RefSeq Acc Id: XM_003822193   ⟹   XP_003822241
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1971,930,148 - 71,948,779 (+)NCBI
Mhudiblu_PPA_v0951,647,404 - 51,665,990 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003822241 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003822241   ⟸   XM_003822193
- Sequence:
RefSeq Acc Id: ENSPPAP00000014806   ⟸   ENSPPAT00000037494


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000030576 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000014806 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000037494 UniProtKB/TrEMBL
Gene3D-CATH 1.10.220.10 UniProtKB/TrEMBL
InterPro Annexin UniProtKB/TrEMBL
  Annexin_repeat UniProtKB/TrEMBL
  Annexin_repeat_CS UniProtKB/TrEMBL
  Annexin_sf UniProtKB/TrEMBL
  ANX1 UniProtKB/TrEMBL
KEGG Report pps:100994302 UniProtKB/TrEMBL
NCBI Gene ANXA1 ENTREZGENE
PANTHER PTHR10502:SF17 UniProtKB/TrEMBL
Pfam Annexin UniProtKB/TrEMBL
PRINTS ANNEXIN UniProtKB/TrEMBL
  ANNEXINI UniProtKB/TrEMBL
PROSITE ANNEXIN UniProtKB/TrEMBL
  ANNEXIN_2 UniProtKB/TrEMBL
SMART ANX UniProtKB/TrEMBL
Superfamily-SCOP SSF47874 UniProtKB/TrEMBL
UniProt A0A2R9AD24_PANPA UniProtKB/TrEMBL