CIITA (class II major histocompatibility complex transactivator) - Rat Genome Database

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Gene: CIITA (class II major histocompatibility complex transactivator) Pan paniscus
Analyze
Symbol: CIITA
Name: class II major histocompatibility complex transactivator
RGD ID: 11983652
Description: ENCODES a protein that exhibits DNA-binding transcription factor binding (ortholog); protein-containing complex binding (ortholog); transcription cis-regulatory region binding (ortholog); INVOLVED IN blocking of symbiont entry into host cell (ortholog); cellular response to electrical stimulus (ortholog); cellular response to exogenous dsRNA (ortholog); ASSOCIATED WITH acute kidney tubular necrosis (ortholog); Addison's disease (ortholog); Albuminuria (ortholog); FOUND IN cell surface (ortholog); PML body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: MHC class II transactivator
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21811,426,662 - 11,492,167 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11615,201,913 - 15,267,425 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0169,819,440 - 9,885,379 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11611,041,434 - 11,090,485 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1611,041,434 - 11,090,485 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell surface  (ISO)
cytosol  (IEA)
nucleoplasm  (IEA)
PML body  (ISO)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CIITA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21811,426,662 - 11,492,167 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11615,201,913 - 15,267,425 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0169,819,440 - 9,885,379 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11611,041,434 - 11,090,485 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1611,041,434 - 11,090,485 (+)Ensemblpanpan1.1panPan2
CIITA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381610,866,206 - 10,943,021 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1610,866,222 - 10,943,021 (+)EnsemblGRCh38hg38GRCh38
GRCh371610,971,055 - 11,030,251 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361610,878,556 - 10,926,341 (+)NCBINCBI36Build 36hg18NCBI36
Build 341610,878,539 - 10,933,676NCBI
Celera1611,140,481 - 11,188,432 (+)NCBICelera
Cytogenetic Map16p13.13NCBI
HuRef1610,888,898 - 10,936,424 (+)NCBIHuRef
CHM1_11610,970,985 - 11,018,760 (+)NCBICHM1_1
T2T-CHM13v2.01610,902,173 - 10,978,992 (+)NCBIT2T-CHM13v2.0
Ciita
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391610,297,877 - 10,348,928 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1610,297,923 - 10,346,282 (+)EnsemblGRCm39 Ensembl
GRCm381610,480,014 - 10,531,064 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1610,480,059 - 10,528,418 (+)EnsemblGRCm38mm10GRCm38
MGSCv371610,488,372 - 10,527,657 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361610,401,857 - 10,441,142 (+)NCBIMGSCv36mm8
Celera1611,120,578 - 11,160,248 (+)NCBICelera
Cytogenetic Map16A1NCBI
cM Map165.65NCBI
Ciita
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8105,646,854 - 5,694,393 (-)NCBIGRCr8
mRatBN7.2105,139,947 - 5,187,493 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl105,140,178 - 5,187,440 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx109,836,592 - 9,883,847 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0109,357,706 - 9,404,970 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0104,995,977 - 5,043,240 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0105,212,621 - 5,260,641 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl105,213,350 - 5,260,608 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0104,036,437 - 4,083,966 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4105,087,174 - 5,133,418 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1105,087,173 - 5,133,418 (-)NCBI
Celera104,158,435 - 4,205,434 (-)NCBICelera
Cytogenetic Map10q11NCBI
Ciita
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554427,603,893 - 7,647,624 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554427,600,903 - 7,647,619 (-)NCBIChiLan1.0ChiLan1.0
CIITA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1631,774,486 - 31,837,025 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl631,774,609 - 31,836,820 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha633,156,962 - 33,219,510 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0631,956,967 - 32,019,399 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl631,956,967 - 31,996,000 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1631,770,183 - 31,832,926 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0631,644,456 - 31,706,901 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0632,068,973 - 32,131,721 (-)NCBIUU_Cfam_GSD_1.0
Ciita
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344111,196,647 - 111,229,034 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365309,033,510 - 9,073,341 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CIITA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl332,172,214 - 32,230,780 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1332,171,706 - 32,230,775 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2333,109,119 - 33,117,697 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CIITA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1510,341,690 - 10,401,988 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl510,372,344 - 10,400,451 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606819,764,657 - 19,814,384 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ciita
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248248,116,537 - 8,153,482 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248248,099,877 - 8,156,661 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_008960373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008960374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034939778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034939779 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034939780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034939781 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034939782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034939783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034939784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034939785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034939786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_034939787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_057300009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_057300010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063598370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063598371 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSPPAT00000048530   ⟹   ENSPPAP00000025700
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1611,041,434 - 11,090,485 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000048537   ⟹   ENSPPAP00000025707
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1611,041,567 - 11,088,806 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000048538   ⟹   ENSPPAP00000025708
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1611,041,567 - 11,075,608 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000048539   ⟹   ENSPPAP00000025709
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1611,060,499 - 11,088,806 (+)Ensembl
RefSeq Acc Id: XM_008960373   ⟹   XP_008958621
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21811,426,662 - 11,475,418 (+)NCBI
NHGRI_mPanPan11615,201,914 - 15,254,581 (+)NCBI
Mhudiblu_PPA_v0169,819,440 - 9,868,223 (+)NCBI
PanPan1.11611,041,434 - 11,090,485 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008960374   ⟹   XP_008958622
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21811,428,153 - 11,475,418 (+)NCBI
NHGRI_mPanPan11615,203,402 - 15,254,581 (+)NCBI
Mhudiblu_PPA_v0169,820,961 - 9,867,712 (+)NCBI
PanPan1.11611,043,203 - 11,089,844 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034939778   ⟹   XP_034795669
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21811,428,152 - 11,486,879 (+)NCBI
NHGRI_mPanPan11615,203,401 - 15,262,138 (+)NCBI
Mhudiblu_PPA_v0169,820,960 - 9,879,684 (+)NCBI
RefSeq Acc Id: XM_034939779   ⟹   XP_034795670
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21811,428,152 - 11,492,167 (+)NCBI
NHGRI_mPanPan11615,203,401 - 15,267,425 (+)NCBI
Mhudiblu_PPA_v0169,820,960 - 9,885,379 (+)NCBI
RefSeq Acc Id: XM_034939780   ⟹   XP_034795671
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21811,428,152 - 11,486,879 (+)NCBI
NHGRI_mPanPan11615,203,401 - 15,262,138 (+)NCBI
Mhudiblu_PPA_v0169,820,960 - 9,878,488 (+)NCBI
RefSeq Acc Id: XM_034939781   ⟹   XP_034795672
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21811,428,153 - 11,475,418 (+)NCBI
NHGRI_mPanPan11615,203,402 - 15,254,581 (+)NCBI
Mhudiblu_PPA_v0169,820,961 - 9,867,712 (+)NCBI
RefSeq Acc Id: XM_034939784   ⟹   XP_034795675
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21811,428,151 - 11,475,418 (+)NCBI
NHGRI_mPanPan11615,203,400 - 15,254,581 (+)NCBI
Mhudiblu_PPA_v0169,820,959 - 9,867,712 (+)NCBI
RefSeq Acc Id: XM_034939785   ⟹   XP_034795676
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21811,428,149 - 11,475,418 (+)NCBI
NHGRI_mPanPan11615,203,399 - 15,254,581 (+)NCBI
Mhudiblu_PPA_v0169,820,957 - 9,867,712 (+)NCBI
RefSeq Acc Id: XM_057300009   ⟹   XP_057155992
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21811,426,662 - 11,486,879 (+)NCBI
NHGRI_mPanPan11615,201,913 - 15,262,138 (+)NCBI
RefSeq Acc Id: XM_057300010   ⟹   XP_057155993
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21811,426,662 - 11,486,879 (+)NCBI
NHGRI_mPanPan11615,201,913 - 15,262,138 (+)NCBI
RefSeq Acc Id: XM_063598370   ⟹   XP_063454440
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21811,428,153 - 11,475,418 (+)NCBI
RefSeq Acc Id: XM_063598371   ⟹   XP_063454441
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21811,428,143 - 11,459,654 (+)NCBI
RefSeq Acc Id: XP_008958621   ⟸   XM_008960373
- Peptide Label: isoform X3
- UniProtKB: A0A2R9BFB3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008958622   ⟸   XM_008960374
- Peptide Label: isoform X1
- UniProtKB: A0A2R9B7Y5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034795676   ⟸   XM_034939785
- Peptide Label: isoform X6
- UniProtKB: A0A2R9BFB3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034795675   ⟸   XM_034939784
- Peptide Label: isoform X5
- UniProtKB: A0A2R9BFB3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034795670   ⟸   XM_034939779
- Peptide Label: isoform X1
- UniProtKB: A0A2R9B7Y5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034795669   ⟸   XM_034939778
- Peptide Label: isoform X1
- UniProtKB: A0A2R9B7Y5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034795671   ⟸   XM_034939780
- Peptide Label: isoform X1
- UniProtKB: A0A2R9B7Y5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034795672   ⟸   XM_034939781
- Peptide Label: isoform X2
- UniProtKB: A0A2R9B7Y5 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000025707   ⟸   ENSPPAT00000048537
Ensembl Acc Id: ENSPPAP00000025708   ⟸   ENSPPAT00000048538
Ensembl Acc Id: ENSPPAP00000025709   ⟸   ENSPPAT00000048539
Ensembl Acc Id: ENSPPAP00000025700   ⟸   ENSPPAT00000048530
RefSeq Acc Id: XP_057155992   ⟸   XM_057300009
- Peptide Label: isoform X3
RefSeq Acc Id: XP_057155993   ⟸   XM_057300010
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063454441   ⟸   XM_063598371
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063454440   ⟸   XM_063598370
- Peptide Label: isoform X7
Protein Domains
NACHT


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000035964 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000048530.1 UniProtKB/TrEMBL
  ENSPPAT00000048537.1 UniProtKB/TrEMBL
  ENSPPAT00000048538.1 UniProtKB/TrEMBL
  ENSPPAT00000048539.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
InterPro Leu-rich_rpt UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
  MHC_II_transact UniProtKB/TrEMBL
  NACHT_NTPase UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
NCBI Gene CIITA ENTREZGENE
PANTHER MHC CLASS II TRANSACTIVATOR UniProtKB/TrEMBL
  MHC CLASS II TRANSACTIVATOR UniProtKB/TrEMBL
Pfam LRR_6 UniProtKB/TrEMBL
  NACHT UniProtKB/TrEMBL
PRINTS MHCIIACTVATR UniProtKB/TrEMBL
PROSITE LRR UniProtKB/TrEMBL
  NACHT UniProtKB/TrEMBL
SMART LRR_RI UniProtKB/TrEMBL
Superfamily-SCOP RNI-like UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A2R9B7Y5 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9B7Z1_PANPA UniProtKB/TrEMBL
  A0A2R9B9E3_PANPA UniProtKB/TrEMBL
  A0A2R9BFB3 ENTREZGENE, UniProtKB/TrEMBL