CIITA (class II major histocompatibility complex transactivator) - Rat Genome Database

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Gene: CIITA (class II major histocompatibility complex transactivator) Homo sapiens
Symbol: CIITA
Name: class II major histocompatibility complex transactivator
RGD ID: 1348941
HGNC Page HGNC:7067
Description: Enables DNA-binding transcription factor binding activity and transcription cis-regulatory region binding activity. Involved in several processes, including positive regulation of MHC class I biosynthetic process; regulation of transcription by RNA polymerase II; and response to type II interferon. Acts upstream of or within response to antibiotic. Located in PML body and cytosol. Implicated in Addison's disease; MHC class II deficiency; autoimmune disease (multiple); and myocardial infarction.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: C2TA; CIITAIV; class II, major histocompatibility complex, transactivator; MHC class II transactivator; MHC class II transactivator type I; MHC class II transactivator type III; MHC2TA; NLR family, acid domain containing; NLRA; nucleotide-binding oligomerization domain, leucine rich repeat and acid domain containing
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381610,866,206 - 10,943,021 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1610,866,222 - 10,943,021 (+)EnsemblGRCh38hg38GRCh38
GRCh371610,971,055 - 11,030,251 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361610,878,556 - 10,926,341 (+)NCBINCBI36Build 36hg18NCBI36
Build 341610,878,539 - 10,933,676NCBI
Celera1611,140,481 - 11,188,432 (+)NCBICelera
Cytogenetic Map16p13.13NCBI
HuRef1610,888,898 - 10,936,424 (+)NCBIHuRef
CHM1_11610,970,985 - 11,018,760 (+)NCBICHM1_1
T2T-CHM13v2.01610,902,173 - 10,978,992 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
5-azacytidine  (EXP)
9-cis-retinoic acid  (EXP)
acetamide  (ISO)
aflatoxin B1  (EXP)
Aflatoxin B2 alpha  (EXP)
all-trans-retinoic acid  (EXP)
allethrin  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
antirheumatic drug  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (EXP)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (ISO)
buta-1,3-diene  (ISO)
butanal  (EXP)
capsaicin  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
Cuprizon  (ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
diarsenic trioxide  (EXP)
dichloromethane  (ISO)
dimethyl fumarate  (EXP)
dimethylarsinic acid  (ISO)
ethylbenzene  (ISO)
fenvalerate  (ISO)
folic acid  (ISO)
gentamycin  (ISO)
lipopolysaccharide  (EXP)
manganese(II) chloride  (ISO)
melphalan  (EXP)
methoxychlor  (ISO)
methyl methanesulfonate  (EXP)
methylarsonic acid  (ISO)
nevirapine  (EXP)
nickel atom  (EXP)
Nor-9-carboxy-delta9-THC  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
pyrethrins  (ISO)
ritonavir  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
simvastatin  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
T-2 toxin  (ISO)
tamibarotene  (EXP)
testosterone  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
trichloroethene  (ISO)
triptonide  (ISO)
tungsten  (ISO)
valproic acid  (EXP)
verapamil  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell surface  (IEA,ISO)
cytosol  (IDA)
nucleoplasm  (IDA,TAS)
nucleus  (IEA)
PML body  (IDA,IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Abnormal CD4:CD8 ratio  (IAGP)
Abnormal facial shape  (IAGP)
Abnormality of humoral immunity  (IAGP)
Acute otitis media  (IAGP)
Agammaglobulinemia  (IAGP)
Anti-citrullinated protein antibody positivity  (IAGP)
Arthralgia  (IAGP)
Autoimmune hemolytic anemia  (IAGP)
Autoimmune thrombocytopenia  (IAGP)
Autoimmunity  (IAGP)
Autosomal recessive inheritance  (IAGP)
Biliary tract abnormality  (IAGP)
Cholangitis  (IAGP)
Chronic hepatitis due to cryptosporidium infection  (IAGP)
Chronic lymphocytic meningitis  (IAGP)
Chronic mucocutaneous candidiasis  (IAGP)
Colitis  (IAGP)
Cutaneous anergy  (IAGP)
Decreased circulating antibody level  (IAGP)
Decreased circulating beta-2-microglobulin level  (IAGP)
Decreased inflammatory response  (IAGP)
Decreased lymphocyte proliferation in response to mitogen  (IAGP)
Decreased proportion of CD4-positive helper T cells  (IAGP)
Diarrhea  (IAGP)
Digital flexor tenosynovitis  (IAGP)
Dysarthria  (IAGP)
Elevated circulating C-reactive protein concentration  (IAGP)
Elevated erythrocyte sedimentation rate  (IAGP)
Failure to thrive  (IAGP)
Fatigue  (IAGP)
Fever  (IAGP)
Gait ataxia  (IAGP)
Hematochezia  (IAGP)
Increased inflammatory response  (IAGP)
Infectious encephalitis  (IAGP)
Inflammation of the large intestine  (IAGP)
Interphalangeal joint erosions  (IAGP)
Joint stiffness  (IAGP)
Joint swelling  (IAGP)
Lack of T cell function  (IAGP)
Malabsorption  (IAGP)
Neutropenia  (IAGP)
Neutropenia in presence of anti-neutropil antibodies  (IAGP)
Pancytopenia  (IAGP)
Panhypogammaglobulinemia  (IAGP)
Polyarticular arthritis  (IAGP)
Protracted diarrhea  (IAGP)
Recurrent bacterial infections  (IAGP)
Recurrent candida infections  (IAGP)
Recurrent fungal infections  (IAGP)
Recurrent herpes  (IAGP)
Recurrent infection of the gastrointestinal tract  (IAGP)
Recurrent lower respiratory tract infections  (IAGP)
Recurrent protozoan infections  (IAGP)
Recurrent respiratory infections  (IAGP)
Recurrent Staphylococcus aureus infections  (IAGP)
Recurrent upper respiratory tract infections  (IAGP)
Recurrent urinary tract infections  (IAGP)
Recurrent viral infections  (IAGP)
Reduced MHC II surface expression  (IAGP)
Rheumatoid arthritis  (IAGP)
Rheumatoid factor positive  (IAGP)
Rhinitis  (IAGP)
Sclerosing cholangitis  (IAGP)
Sinusitis  (IAGP)
Skin rash  (IAGP)
Swan neck-like deformities of the fingers  (IAGP)
T lymphocytopenia  (IAGP)
Thrombocytopenia  (IAGP)
Vasculitis  (IAGP)
Villous atrophy  (IAGP)
Viral hepatitis  (IAGP)
Weight loss  (IAGP)

References - curated
# Reference Title Reference Citation
1. Promoter polymorphism rs3087456 in the MHC class II transactivator gene is not associated with susceptibility for selected autoimmune diseases in German patient groups. Akkad DA, etal., Int J Immunogenet. 2006 Feb;33(1):59-61.
2. Two novel mutations in the MHC class II transactivator CIITA in a second patient from MHC class II deficiency complementation group A. Bontron S, etal., Hum Genet. 1997 Apr;99(4):541-6.
3. Successful treatment of experimental autoimmune myocarditis by adenovirus-mediated gene transfer of antisense CIITA. Cai G, etal., J Mol Cell Cardiol. 2005 Apr;38(4):593-605.
4. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
5. Vra4 congenic rats with allelic differences in the class II transactivator gene display altered susceptibility to experimental autoimmune encephalomyelitis. Harnesk K, etal., J Immunol. 2008 Mar 1;180(5):3289-96.
6. Overexpression of CIITA in T cells aggravates Th2-mediated colitis in mice. Kim TW, etal., J Korean Med Sci. 2006 Oct;21(5):877-82.
7. Single nucleotide polymorphisms in the gene encoding the major histocompatibility complex class II transactivator (CIITA) in systemic lupus erythematosus. Koizumi K, etal., Ann Rheum Dis. 2005 Jun;64(6):947-50.
8. Major histocompatibility complex class II transactivator inhibits cysteine-rich 61 expression in osteoblastic cells and its implication in the pathogenesis of periapical lesions. Lee YL, etal., J Endod. 2010 Jun;36(6):1021-5. doi: 10.1016/j.joen.2010.03.009. Epub 2010 Apr 21.
9. Polymorphism in the MHC2TA gene is associated with features of the metabolic syndrome and cardiovascular mortality. Lindholm E, etal., PLoS One. 2006 Dec 20;1:e64.
10. A polymorphic variant in the MHC2TA gene is not associated with systemic lupus erythematosus. Linga-Reddy MV, etal., Tissue Antigens. 2007 Nov;70(5):412-4. Epub 2007 Aug 17.
11. Chromosomal region 16p13: further evidence of increased predisposition to immune diseases. Martinez A, etal., Ann Rheum Dis. 2010 Jan;69(1):309-11. Epub .
12. The MHC2TA-168A/G and +1614G/C polymorphisms and risk for multiple sclerosis or chronic inflammatory arthropathies. O'Doherty C, etal., Tissue Antigens. 2007 Sep;70(3):247-51.
13. Protective effect of A at position - 168 in the type III promoter of the MHCIITA gene in systemic lupus erythematosus. Okamoto H, etal., Ann Rheum Dis. 2007 Sep;66(9):1263-4.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. Susceptibility of mice deficient in the MHC class II transactivator to infection with Mycobacterium tuberculosis.