Ciita (class II transactivator) - Rat Genome Database

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Gene: Ciita (class II transactivator) Mus musculus
Analyze
Symbol: Ciita
Name: class II transactivator
RGD ID: 734236
MGI Page MGI
Description: Predicted to have activating transcription factor binding activity; protein C-terminus binding activity; and transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; and response to interferon-gamma. Predicted to localize to PML body; cell surface; and cytosol. Is expressed in bladder; central nervous system; and retina. Used to study MHC class II deficiency and osteoporosis. Human ortholog(s) of this gene implicated in Addison's disease; MHC class II deficiency; autoimmune disease (multiple); and myocardial infarction. Orthologous to human CIITA (class II major histocompatibility complex transactivator).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C2t; C2ta; EG669998; Gm9475; MGC130299; MHC class II transactivator; Mhc2ta; predicted gene 9475
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391610,297,877 - 10,348,928 (+)NCBIGRCm39mm39
GRCm39 Ensembl1610,297,923 - 10,346,282 (+)Ensembl
GRCm381610,480,014 - 10,531,064 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1610,480,059 - 10,528,418 (+)EnsemblGRCm38mm10GRCm38
MGSCv371610,488,372 - 10,527,657 (+)NCBIGRCm37mm9NCBIm37
MGSCv361610,401,857 - 10,441,142 (+)NCBImm8
Celera1611,120,578 - 11,160,248 (+)NCBICelera
Cytogenetic Map16A1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell surface  (ISO)
cytosol  (ISO)
nucleoplasm  (ISO)
nucleus  (IEA)
PML body  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal B cell physiology  (IAGP)
abnormal CD4-positive T cell differentiation  (IEA)
abnormal CD4-positive, alpha-beta T cell physiology  (IAGP)
abnormal CD8-positive, alpha-beta T cell differentiation  (IEA)
abnormal circulating glucose level  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal dendritic cell physiology  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal immunoglobulin level  (IAGP)
abnormal inflammatory response  (IAGP)
abnormal level of surface class II molecules  (IAGP)
abnormal lymphocyte physiology  (IAGP)
abnormal MHC II cell surface expression on macrophages  (IAGP)
abnormal popliteal lymph node morphology  (IAGP)
abnormal susceptibility to infection  (IAGP)
abnormal T cell differentiation  (IAGP)
abnormal T cell physiology  (IAGP)
abnormal T cell subpopulation ratio  (IAGP)
abnormal T-helper 1 physiology  (IAGP)
abnormal trabecular bone morphology  (IAGP)
absent CD4-positive, alpha beta T cells  (IAGP)
decreased bone trabecula number  (IAGP)
decreased CD4-positive, alpha beta T cell number  (IAGP)
decreased dendritic cell number  (IAGP)
decreased IgG level  (IAGP)
decreased single-positive T cell number  (IAGP)
decreased susceptibility to autoimmune diabetes  (IAGP)
decreased susceptibility to experimental autoimmune encephalomyelitis  (IAGP)
decreased susceptibility to parasitic infection  (IAGP)
decreased T cell proliferation  (IAGP)
decreased trabecular bone volume  (IAGP)
impaired humoral immune response  (IEA)
increased bone resorption  (IAGP)
increased bone trabecular spacing  (IAGP)
increased CD4-positive, alpha beta T cell number  (IAGP)
increased CD8-positive, alpha-beta T cell number  (IAGP)
increased circulating type I collagen C-terminal telopeptide level  (IAGP)
increased double-positive T cell number  (IAGP)
increased IgM level  (IAGP)
increased osteoclast cell number  (IAGP)
increased susceptibility to parasitic infection  (IAGP)
insulitis  (IAGP)
no abnormal phenotype detected  (IAGP)
osteoporosis  (IAGP)
pancreas inflammation  (IAGP)
periinsulitis  (IAGP)
References

References - curated
1. Akkad DA, etal., Int J Immunogenet. 2006 Feb;33(1):59-61.
2. Bontron S, etal., Hum Genet. 1997 Apr;99(4):541-6.
3. Cai G, etal., J Mol Cell Cardiol. 2005 Apr;38(4):593-605.
4. Harnesk K, etal., J Immunol. 2008 Mar 1;180(5):3289-96.
5. Kim TW, etal., J Korean Med Sci. 2006 Oct;21(5):877-82.
6. Koizumi K, etal., Ann Rheum Dis. 2005 Jun;64(6):947-50.
7. Lee YL, etal., J Endod. 2010 Jun;36(6):1021-5. doi: 10.1016/j.joen.2010.03.009. Epub 2010 Apr 21.
8. Lindholm E, etal., PLoS One. 2006 Dec 20;1:e64.
9. Linga-Reddy MV, etal., Tissue Antigens. 2007 Nov;70(5):412-4. Epub 2007 Aug 17.
10. Martinez A, etal., Ann Rheum Dis. 2010 Jan;69(1):309-11. Epub .
11. MGD data from the GO Consortium
12. MGD IEA
13. O'Doherty C, etal., Tissue Antigens. 2007 Sep;70(3):247-51.
14. Okamoto H, etal., Ann Rheum Dis. 2007 Sep;66(9):1263-4.
15. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
16. Pipeline to import KEGG annotations from KEGG into RGD
17. Reed JC, etal., Genome Res 2003 Jun;13(6B):1376-88.
18. Repique CJ, etal., Scand J Immunol. 2003 Jul;58(1):15-22.
19. RGD automated import pipeline
20. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. RGD automated import pipeline for gene-chemical interactions
22. Sims TN, etal., Transplantation. 1997 Dec 27;64(12):1657-64.
23. Skinningsrud B, etal., J Clin Endocrinol Metab. 2008 Sep;93(9):3310-7. Epub 2008 Jul 1.
24. Swanberg M, etal., Nat Genet 2005 May;37(5):486-94. Epub 2005 Apr 10.
25. Takeuchi O, etal., J Am Soc Nephrol. 2003 Nov;14(11):2823-32.
26. Wiszniewski W, etal., J Immunol. 2001 Aug 1;167(3):1787-94.
27. Zuvich RL, etal., Hum Mol Genet. 2011 Sep 1;20(17):3517-24. Epub 2011 Jun 8.
Additional References at PubMed
PMID:8294875   PMID:8620527   PMID:8624807   PMID:8990384   PMID:8995190   PMID:9164958   PMID:9184229   PMID:9491996   PMID:9521055   PMID:9548512   PMID:9885917   PMID:10201997  
PMID:10204493   PMID:10349636   PMID:10438942   PMID:10452977   PMID:10637268   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11514597   PMID:11532347   PMID:11564890   PMID:11721060  
PMID:11937578   PMID:11970984   PMID:11978778   PMID:12102254   PMID:12218125   PMID:12471103   PMID:12477932   PMID:12506036   PMID:12525570   PMID:12538670   PMID:12748124   PMID:12923292  
PMID:14681479   PMID:14764672   PMID:14768052   PMID:15100295   PMID:15162420   PMID:15322541   PMID:15446308   PMID:15494498   PMID:15596523   PMID:15661876   PMID:15876426   PMID:15964851  
PMID:16081800   PMID:16141072   PMID:16141073   PMID:16210330   PMID:16226503   PMID:16226504   PMID:16236793   PMID:16254146   PMID:16280321   PMID:16547269   PMID:16569676   PMID:16602821  
PMID:16703565   PMID:16717113   PMID:16783635   PMID:16863914   PMID:16908858   PMID:16982097   PMID:17072917   PMID:17088432   PMID:17346795   PMID:17627890   PMID:17724129   PMID:17982082  
PMID:18245089   PMID:18287559   PMID:18292501   PMID:18337172   PMID:18359773   PMID:18768863   PMID:18799151   PMID:18923103   PMID:19041327   PMID:19224634   PMID:19234195   PMID:19481818  
PMID:19897249   PMID:20038602   PMID:20059953   PMID:20080304   PMID:20211142   PMID:20363966   PMID:20431619   PMID:20696698   PMID:20705943   PMID:21203976   PMID:21216962   PMID:21267068  
PMID:21321116   PMID:21358747   PMID:21426357   PMID:21464590   PMID:21478404   PMID:21481937   PMID:21499269   PMID:21547436   PMID:21576360   PMID:21739421   PMID:21873635   PMID:22084437  
PMID:22112519   PMID:22209772   PMID:22218223   PMID:22275866   PMID:22294690   PMID:22315415   PMID:22341446   PMID:22371391   PMID:22411629   PMID:22453923   PMID:22552229   PMID:22645137  
PMID:22711889   PMID:22851713   PMID:22908323   PMID:22973039   PMID:22974124   PMID:22988097   PMID:23087187   PMID:23144170   PMID:23175229   PMID:23264660   PMID:23300712   PMID:23382543  
PMID:23441229   PMID:23468840   PMID:23621273   PMID:23681904   PMID:23733190   PMID:23756162   PMID:23776173   PMID:23881368   PMID:23943651   PMID:24038328   PMID:24055710   PMID:24327761  
PMID:24452999   PMID:24466045   PMID:24478085   PMID:24489792   PMID:24634495   PMID:24842370   PMID:24901123   PMID:24987872   PMID:25101797   PMID:25198660   PMID:25223984   PMID:25347469  
PMID:25811463   PMID:25908663   PMID:26621778   PMID:26750312   PMID:26972221   PMID:27185856   PMID:27221978   PMID:27659424   PMID:27861821   PMID:28002729   PMID:28348230   PMID:28424681  
PMID:28608405   PMID:29238041   PMID:29975708   PMID:30165873   PMID:30327417   PMID:30584641   PMID:32325033   PMID:32855215  


Genomics

Comparative Map Data
Ciita
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391610,297,877 - 10,348,928 (+)NCBIGRCm39mm39
GRCm39 Ensembl1610,297,923 - 10,346,282 (+)Ensembl
GRCm381610,480,014 - 10,531,064 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1610,480,059 - 10,528,418 (+)EnsemblGRCm38mm10GRCm38
MGSCv371610,488,372 - 10,527,657 (+)NCBIGRCm37mm9NCBIm37
MGSCv361610,401,857 - 10,441,142 (+)NCBImm8
Celera1611,120,578 - 11,160,248 (+)NCBICelera
Cytogenetic Map16A1NCBI
CIITA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1610,866,222 - 10,943,021 (+)EnsemblGRCh38hg38GRCh38
GRCh381610,866,208 - 10,941,562 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371610,971,055 - 11,030,251 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361610,878,556 - 10,926,341 (+)NCBINCBI36hg18NCBI36
Build 341610,878,539 - 10,933,676NCBI
Celera1611,140,481 - 11,188,432 (+)NCBI
Cytogenetic Map16p13.13NCBI
HuRef1610,888,898 - 10,936,424 (+)NCBIHuRef
CHM1_11610,970,985 - 11,018,760 (+)NCBICHM1_1
Ciita
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2105,139,947 - 5,187,493 (-)NCBI
Rnor_6.0 Ensembl105,213,350 - 5,260,608 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0105,212,621 - 5,260,641 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0104,036,437 - 4,083,966 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4105,087,174 - 5,133,418 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1105,087,173 - 5,133,418 (-)NCBI
Celera104,158,435 - 4,205,434 (-)NCBICelera
Cytogenetic Map10q11NCBI
Ciita
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554427,603,893 - 7,647,624 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554427,600,903 - 7,647,619 (-)NCBIChiLan1.0ChiLan1.0
CIITA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11611,041,434 - 11,090,485 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1611,041,434 - 11,090,485 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0169,819,440 - 9,885,379 (+)NCBIMhudiblu_PPA_v0panPan3
CIITA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1631,774,486 - 31,837,025 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl631,774,609 - 31,836,820 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha633,156,962 - 33,219,510 (-)NCBI
ROS_Cfam_1.0631,956,967 - 32,019,399 (-)NCBI
UMICH_Zoey_3.1631,770,183 - 31,832,926 (-)NCBI
UNSW_CanFamBas_1.0631,644,456 - 31,706,901 (-)NCBI
UU_Cfam_GSD_1.0632,068,973 - 32,131,721 (-)NCBI
Ciita
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344111,196,647 - 111,229,034 (+)NCBI
SpeTri2.0NW_0049365309,033,510 - 9,073,341 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CIITA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl332,172,214 - 32,230,780 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1332,171,706 - 32,230,775 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2333,109,119 - 33,117,697 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CIITA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1510,341,690 - 10,401,988 (+)NCBI
ChlSab1.1 Ensembl510,372,344 - 10,400,451 (+)Ensembl
Vero_WHO_p1.0NW_02366606819,764,657 - 19,814,384 (-)NCBI
Ciita
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248248,099,877 - 8,156,661 (+)NCBI


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141060Pbwg19_mpostnatal body weight growth 19 (mouse)Not determined16120963024Mouse
1300632Loca2_mlocomotor activity 2 (mouse)Not determined16122682710Mouse
10043879Adip25_madiposity 25 (mouse)Not determined16122702454Mouse
1301575Tanidd3_mtally ho associated non-insulin dependednt diabetes mellitus 3 (mouse)Not determined16123079875Mouse
1301970Heal11_mwound healing/regeneration 11 (mouse)Not determined16124445989Mouse
4141468Nhdlq10_mnon-HDL QTL 10 (mouse)Not determined16124445989Mouse
1301384Dice1_mdetermination of interleukin 4 commitment 1 (mouse)Not determined16128616494Mouse
10402497Lmr23_mleishmaniasis resistance 23 (mouse)Not determined16129856336Mouse
1301559Bbaa19_mB.burgdorferi-associated arthritis 19 (mouse)Not determined16130249113Mouse
10412289Ppsl_mplasma P-selectin levels (mouse)Not determined16130996708Mouse
27095908Scvln7_msacral vertebrae length 2, 5 week (mouse)16350000040000000Mouse
27226768Tibl9_mtibia length 9, 5 week (mouse)16350000051600000Mouse
27226785Feml12_mfemur length 12, 5 week (mouse)16350000064800000Mouse
1302106Rapop1_mradiation-induced apoptosis 1 (mouse)Not determined16396291515913189Mouse
26884432Zlq7_mzygomatic length QTL 7, 10 week (mouse)16400000064800000Mouse
38501069Tip4_mtuberculosis immunophenotype 4, IFN-g level (mouse)16450000044700000Mouse
1301443Mopkd2_mmodifier of polycystic kidney disease progression 2 (mouse)Not determined16482756438827664Mouse
1300656Bgeq15_mbody growth early QTL 15 (mouse)Not determined16595650239956690Mouse
1301945Skl7_mskeletal size (tail length) 7 (mouse)Not determined16595650239956690Mouse
1300987Skull23_mskull morphology 23 (mouse)Not determined16595650239956690Mouse
1300943Skts9_mskin tumor susceptibility 9 (mouse)Not determined16595650239956690Mouse
4141010Bbq1_mbrain and behavior QTL 1 (mouse)Not determined16665914535200846Mouse
1357763Lp1_mlymphocyte proliferation 1 (mouse)Not determined16672511565669666Mouse
4142460Nilac10_mnicotine induced locomotor activity 10 (mouse)Not determined16731904229406653Mouse
1357658Dice1a_mdetermination of interleukin 4 commitment 1a (mouse)Not determined16798323611139842Mouse
11251724Ewc6_methanol withdrawal and consumption 6 (mouse)16840730242407302Mouse
26884376Skwq4_mskull length QTL 4, 5 week (mouse)16860000091100000Mouse
10043978Obq35_mobesity QTL 35 (mouse)Not determined161006288144062881Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:717
Count of miRNA genes:421
Interacting mature miRNAs:505
Transcripts:ENSMUST00000023147
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001243760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001243761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001302618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001302619 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_007575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006521724 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006521726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011245810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036159756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001781783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC122352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF042158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF042159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF100709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF100710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI182240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK040723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK138822 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK143956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153609 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155184 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK155311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK163054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC107330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC107331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE850370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466521 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U46562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U60653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000023147   ⟹   ENSMUSP00000023147
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1610,488,279 - 10,528,418 (+)Ensembl
RefSeq Acc Id: ENSMUST00000229906
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1610,488,178 - 10,519,168 (+)Ensembl
RefSeq Acc Id: ENSMUST00000230146   ⟹   ENSMUSP00000154946
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1610,489,781 - 10,526,426 (+)Ensembl
RefSeq Acc Id: ENSMUST00000230392   ⟹   ENSMUSP00000155635
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1610,489,783 - 10,492,234 (+)Ensembl
RefSeq Acc Id: ENSMUST00000230395   ⟹   ENSMUSP00000155517
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1610,480,059 - 10,526,426 (+)Ensembl
RefSeq Acc Id: ENSMUST00000230450   ⟹   ENSMUSP00000155002
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1610,480,164 - 10,526,426 (+)Ensembl
RefSeq Acc Id: ENSMUST00000230533
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1610,480,151 - 10,512,857 (+)Ensembl
RefSeq Acc Id: ENSMUST00000230892   ⟹   ENSMUSP00000155232
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1610,489,746 - 10,503,893 (+)Ensembl
RefSeq Acc Id: NM_001243760   ⟹   NP_001230689
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391610,297,936 - 10,345,504 (+)NCBI
GRCm381610,480,072 - 10,527,640 (+)NCBI
Celera1611,113,679 - 11,160,324 (+)NCBI
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001243761   ⟹   NP_001230690
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391610,307,645 - 10,345,504 (+)NCBI
GRCm381610,489,781 - 10,527,640 (+)NCBI
Celera1611,113,679 - 11,160,324 (+)NCBI
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001302618   ⟹   NP_001289547
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391610,297,936 - 10,345,504 (+)NCBI
GRCm381610,480,072 - 10,527,640 (+)NCBI
Celera1611,113,679 - 11,160,324 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001302619   ⟹   NP_001289548
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391610,297,936 - 10,345,504 (+)NCBI
GRCm381610,480,072 - 10,527,640 (+)NCBI
Celera1611,113,679 - 11,160,324 (+)NCBI
Sequence:
RefSeq Acc Id: NM_007575   ⟹   NP_031601
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391610,306,042 - 10,345,504 (+)NCBI
GRCm381610,488,178 - 10,527,640 (+)NCBI
MGSCv371610,488,372 - 10,527,657 (+)RGD
Celera1611,113,679 - 11,160,324 (+)NCBI
cM Map16 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006521724   ⟹   XP_006521787
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391610,297,877 - 10,338,825 (+)NCBI
GRCm381610,480,014 - 10,520,961 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006521726   ⟹   XP_006521789
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391610,297,878 - 10,336,429 (+)NCBI
GRCm381610,480,014 - 10,518,565 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011245810   ⟹   XP_011244112
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391610,307,558 - 10,348,928 (+)NCBI
GRCm381610,489,695 - 10,531,064 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036159756   ⟹   XP_036015649
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391610,311,483 - 10,348,928 (+)NCBI
RefSeq Acc Id: XR_001781783
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391610,297,879 - 10,336,239 (+)NCBI
GRCm381610,480,015 - 10,531,064 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001230689 (Get FASTA)   NCBI Sequence Viewer  
  NP_001230690 (Get FASTA)   NCBI Sequence Viewer  
  NP_001289547 (Get FASTA)   NCBI Sequence Viewer  
  NP_001289548 (Get FASTA)   NCBI Sequence Viewer  
  NP_031601 (Get FASTA)   NCBI Sequence Viewer  
  XP_006521787 (Get FASTA)   NCBI Sequence Viewer  
  XP_006521789 (Get FASTA)   NCBI Sequence Viewer  
  XP_011244112 (Get FASTA)   NCBI Sequence Viewer  
  XP_036015649 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB05004 (Get FASTA)   NCBI Sequence Viewer  
  AAB48859 (Get FASTA)   NCBI Sequence Viewer  
  AAB92364 (Get FASTA)   NCBI Sequence Viewer  
  AAB92365 (Get FASTA)   NCBI Sequence Viewer  
  AAC34366 (Get FASTA)   NCBI Sequence Viewer  
  AAC34367 (Get FASTA)   NCBI Sequence Viewer  
  AAF06838 (Get FASTA)   NCBI Sequence Viewer  
  AAF06839 (Get FASTA)   NCBI Sequence Viewer  
  AAI07331 (Get FASTA)   NCBI Sequence Viewer  
  AAI07332 (Get FASTA)   NCBI Sequence Viewer  
  BAC30683 (Get FASTA)   NCBI Sequence Viewer  
  BAE23789 (Get FASTA)   NCBI Sequence Viewer  
  BAE25629 (Get FASTA)   NCBI Sequence Viewer  
  BAE32115 (Get FASTA)   NCBI Sequence Viewer  
  BAE33100 (Get FASTA)   NCBI Sequence Viewer  
  BAE33182 (Get FASTA)   NCBI Sequence Viewer  
  BAE37173 (Get FASTA)   NCBI Sequence Viewer  
  EDK97316 (Get FASTA)   NCBI Sequence Viewer  
  EDK97317 (Get FASTA)   NCBI Sequence Viewer  
  EDK97318 (Get FASTA)   NCBI Sequence Viewer  
  EDK97319 (Get FASTA)   NCBI Sequence Viewer  
  P79621 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_031601   ⟸   NM_007575
- Peptide Label: isoform 2
- UniProtKB: P79621 (UniProtKB/Swiss-Prot),   Q3KNE0 (UniProtKB/TrEMBL),   Q3U5G4 (UniProtKB/TrEMBL),   Q8HW99 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001230689   ⟸   NM_001243760
- Peptide Label: isoform 1
- UniProtKB: Q3KNE0 (UniProtKB/TrEMBL),   Q3U5G4 (UniProtKB/TrEMBL),   Q3UNW8 (UniProtKB/TrEMBL),   Q3UU40 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001230690   ⟸   NM_001243761
- Peptide Label: isoform 3
- UniProtKB: P79621 (UniProtKB/Swiss-Prot),   Q3KNE0 (UniProtKB/TrEMBL),   Q3U5G4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006521787   ⟸   XM_006521724
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006521789   ⟸   XM_006521726
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: NP_001289548   ⟸   NM_001302619
- Peptide Label: isoform 5
- UniProtKB: P79621 (UniProtKB/Swiss-Prot),   Q3KNE0 (UniProtKB/TrEMBL),   Q3U5G4 (UniProtKB/TrEMBL),   Q3UNW8 (UniProtKB/TrEMBL),   Q3UU40 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001289547   ⟸   NM_001302618
- Peptide Label: isoform 4
- UniProtKB: P79621 (UniProtKB/Swiss-Prot),   Q3KNE0 (UniProtKB/TrEMBL),   Q3U5G4 (UniProtKB/TrEMBL),   Q3UNW8 (UniProtKB/TrEMBL),   Q3UU40 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011244112   ⟸   XM_011245810
- Peptide Label: isoform X2
- UniProtKB: P79621 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000155232   ⟸   ENSMUST00000230892
RefSeq Acc Id: ENSMUSP00000155002   ⟸   ENSMUST00000230450
RefSeq Acc Id: ENSMUSP00000155517   ⟸   ENSMUST00000230395
RefSeq Acc Id: ENSMUSP00000155635   ⟸   ENSMUST00000230392
RefSeq Acc Id: ENSMUSP00000154946   ⟸   ENSMUST00000230146
RefSeq Acc Id: ENSMUSP00000023147   ⟸   ENSMUST00000023147
RefSeq Acc Id: XP_036015649   ⟸   XM_036159756
- Peptide Label: isoform X2
Protein Domains
NACHT

Promoters
RGD ID:8685420
Promoter ID:EPDNEW_M20740
Type:initiation region
Name:Ciita_1
Description:Mus musculus class II transactivator , transcript variant 3,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381610,480,072 - 10,480,132EPDNEW
RGD ID:6826911
Promoter ID:MM_KWN:20081
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Spleen
Transcripts:ENSMUST00000100187,   NM_007575
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361610,488,276 - 10,488,777 (+)MPROMDB
RGD ID:6826787
Promoter ID:MM_KWN:20082
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lung
Transcripts:ENSMUST00000100186,   UC007YDV.1,   UC007YDW.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361610,489,496 - 10,489,996 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:108445 AgrOrtholog
Ensembl Genes ENSMUSG00000022504 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000023147 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000154946 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000155002 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000155232 UniProtKB/TrEMBL
  ENSMUSP00000155517 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000155635 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000023147 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000230146 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000230392 UniProtKB/TrEMBL
  ENSMUST00000230395 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000230450 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000230892 UniProtKB/TrEMBL
Gene3D-CATH 3.80.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Leu-rich_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MHC_II_transact UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NACHT_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:108445 ENTREZGENE
NCBI Gene 12265 ENTREZGENE
Pfam LRR_6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NACHT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ciita PhenoGen
PRINTS MHCIIACTVATR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NACHT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A2R8VHC7_MOUSE UniProtKB/TrEMBL
  A0A2R8VHL9_MOUSE UniProtKB/TrEMBL
  A0A2R8W6Z7_MOUSE UniProtKB/TrEMBL
  C2TA_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3KND9_MOUSE UniProtKB/TrEMBL
  Q3KNE0 ENTREZGENE, UniProtKB/TrEMBL
  Q3TR57_MOUSE UniProtKB/TrEMBL
  Q3U2F8_MOUSE UniProtKB/TrEMBL
  Q3U2P0_MOUSE UniProtKB/TrEMBL
  Q3U5G4 ENTREZGENE, UniProtKB/TrEMBL
  Q3UNW8 ENTREZGENE, UniProtKB/TrEMBL
  Q3UU40 ENTREZGENE, UniProtKB/TrEMBL
  Q8HW99 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary O46787 UniProtKB/Swiss-Prot
  O78036 UniProtKB/Swiss-Prot
  O78109 UniProtKB/Swiss-Prot
  Q31115 UniProtKB/Swiss-Prot
  Q9TPP1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-05 Ciita  class II transactivator  Gm9475  predicted gene 9475  Data Merged 737654 PROVISIONAL