LOC100972354 (interferon alpha-2) - Rat Genome Database

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Gene: LOC100972354 (interferon alpha-2) Pan paniscus
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Symbol: LOC100972354 (Ensembl: IFNA2)
Name: interferon alpha-2 (Ensembl:interferon alpha 2)
RGD ID: 11974528
Description: ENCODES a protein that exhibits cytokine activity (inferred); cytokine receptor binding (inferred); INVOLVED IN cell surface receptor signaling pathway via STAT (inferred); defense response (inferred); defense response to virus (inferred); ASSOCIATED WITH Abdominal Pain (ortholog); acute kidney failure (ortholog); adult T-cell leukemia/lymphoma (ortholog); FOUND IN extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: IFNA2; interferon alpha 2
RGD Orthologs
Human
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v211103,147,073 - 103,148,272 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan19103,153,018 - 103,154,217 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0921,245,017 - 21,246,210 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1921,862,557 - 21,863,690 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl921,863,062 - 21,863,736 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Abdominal Pain  (ISO)
acute kidney failure  (ISO)
adult T-cell leukemia/lymphoma  (ISO)
anemia  (ISO)
Anorexia  (ISO)
anterior ischemic optic neuropathy  (ISO)
anxiety disorder  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chills  (ISO)
Chronic Hepatitis  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
chronic myeloid leukemia  (ISO)
Colorectal Neoplasms  (ISO)
common cold  (ISO)
depressive disorder  (ISO)
diarrhea  (ISO)
disease of mental health  (ISO)
Epithelioid Hemangioendothelioma  (ISO)
essential thrombocythemia  (ISO)
Experimental Liver Cirrhosis  (ISO)
Fatigue  (ISO)
Fever  (ISO)
Flavivirus Infections  (ISO)
follicular lymphoma  (ISO)
glioblastoma  (ISO)
Headache  (ISO)
hemolytic anemia  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
Hepatomegaly  (ISO)
Hodgkin's lymphoma  (ISO)
Hypertriglyceridemia  (ISO)
intestinal perforation  (ISO)
kidney failure  (ISO)
leukopenia  (ISO)
liver cirrhosis  (ISO)
melanoma  (ISO)
Meningism  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
multiple myeloma  (ISO)
myocardial infarction  (ISO)
Nausea  (ISO)
neutropenia  (ISO)
non-Hodgkin lymphoma  (ISO)
Pain  (ISO)
pancreatic cancer  (ISO)
polycythemia vera  (ISO)
Polyomavirus Infections  (ISO)
pterygium  (ISO)
Raynaud disease  (ISO)
renal cell carcinoma  (ISO)
retinal detachment  (ISO)
retinal disease  (ISO)
schizophrenia  (ISO)
Sepsis  (ISO)
skin disease  (ISO)
somatoform disorder  (ISO)
squamous cell carcinoma  (ISO)
steatotic liver disease  (ISO)
Stevens-Johnson syndrome  (ISO)
stomatitis  (ISO)
thrombocytopenia  (ISO)
Thyroid Neoplasms  (ISO)
Tinnitus  (ISO)
transitional cell carcinoma  (ISO)
urinary bladder cancer  (ISO)
Viremia  (ISO)
Vogt-Koyanagi-Harada disease  (ISO)
Vomiting  (ISO)
Weight Gain  (ISO)
Weight Loss  (ISO)
withdrawal disorder  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
LOC100972354
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v211103,147,073 - 103,148,272 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan19103,153,018 - 103,154,217 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0921,245,017 - 21,246,210 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1921,862,557 - 21,863,690 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl921,863,062 - 21,863,736 (-)Ensemblpanpan1.1panPan2
IFNA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38921,384,255 - 21,385,398 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl921,384,255 - 21,385,398 (-)EnsemblGRCh38hg38GRCh38
GRCh37921,384,254 - 21,385,397 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36921,374,254 - 21,375,396 (-)NCBINCBI36Build 36hg18NCBI36
Build 34921,374,253 - 21,375,396NCBI
Celera921,322,568 - 21,323,710 (-)NCBICelera
Cytogenetic Map9p21.3NCBI
HuRef921,347,656 - 21,348,798 (-)NCBIHuRef
CHM1_1921,384,072 - 21,385,214 (-)NCBICHM1_1
T2T-CHM13v2.0921,398,432 - 21,399,575 (-)NCBIT2T-CHM13v2.0
IFNA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11258,468,018 - 58,469,825 (+)NCBIChlSab1.1ChlSab1.1chlSab2


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003830676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSPPAT00000023181   ⟹   ENSPPAP00000005073
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl921,863,062 - 21,863,736 (-)Ensembl
RefSeq Acc Id: XM_003830676   ⟹   XP_003830724
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v211103,147,073 - 103,148,272 (+)NCBI
NHGRI_mPanPan19103,153,018 - 103,154,217 (+)NCBI
Mhudiblu_PPA_v0921,245,017 - 21,246,210 (-)NCBI
PanPan1.1921,862,557 - 21,863,690 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003830724 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000005073.1
RefSeq Acc Id: XP_003830724   ⟸   XM_003830676
- UniProtKB: A0A2R8ZJA8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000005073   ⟸   ENSPPAT00000023181


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000021138 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000023181.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.10 UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/TrEMBL
  Interferon_alpha/beta/delta UniProtKB/TrEMBL
NCBI Gene IFNA2 ENTREZGENE
PANTHER INTERFERON ALPHA-2 UniProtKB/TrEMBL
  PTHR11691 UniProtKB/TrEMBL
Pfam Interferon UniProtKB/TrEMBL
PRINTS INTERFERONAB UniProtKB/TrEMBL
SMART IFabd UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/TrEMBL
UniProt A0A2R8ZJA8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-07-01 LOC100972354  interferon alpha-2  IFNA2  interferon alpha 2  Symbol and/or name change 5135510 APPROVED