LOC100988550 (signal transducer and activator of transcription 5A) - Rat Genome Database

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Gene: LOC100988550 (signal transducer and activator of transcription 5A) Pan paniscus
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Symbol: LOC100988550
Name: signal transducer and activator of transcription 5A
RGD ID: 11689961
Description: ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); INVOLVED IN cellular response to granulocyte macrophage colony-stimulating factor stimulus (ortholog); cytokine-mediated signaling pathway (ortholog); development of secondary female sexual characteristics (ortholog); PARTICIPATES IN erythropoietin signaling pathway; granulocyte-macrophage colony-stimulating factor signaling pathway; interleukin-12 signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); Animal Mammary Neoplasms (ortholog); breast lobular carcinoma (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: STAT5A
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11715,228,465 - 15,251,783 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1715,228,465 - 15,251,783 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01715,005,025 - 15,029,110 (-)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to granulocyte macrophage colony-stimulating factor stimulus  (ISO)
cytokine-mediated signaling pathway  (ISO)
development of secondary female sexual characteristics  (ISO)
development of secondary male sexual characteristics  (ISO)
epithelial cell differentiation involved in prostate gland development  (ISO)
female pregnancy  (ISO)
growth hormone receptor signaling pathway via JAK-STAT  (ISO)
lactation  (ISO)
lipid storage  (ISO)
luteinization  (ISO)
mammary gland development  (ISO)
mammary gland epithelium development  (ISO)
mammary gland involution  (ISO)
multicellular organismal reproductive process  (ISO)
natural killer cell differentiation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of erythrocyte differentiation  (ISO)
negative regulation of mast cell apoptotic process  (ISO)
peptidyl-tyrosine phosphorylation  (ISO)
Peyer's patch development  (ISO)
positive regulation of activated T cell proliferation  (ISO)
positive regulation of B cell differentiation  (ISO)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of gamma-delta T cell differentiation  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of interleukin-2 production  (ISO)
positive regulation of lymphocyte differentiation  (ISO)
positive regulation of mast cell differentiation  (ISO)
positive regulation of mast cell proliferation  (ISO)
positive regulation of mitotic cell cycle  (ISO)
positive regulation of multicellular organism growth  (ISO)
positive regulation of natural killer cell differentiation  (ISO)
positive regulation of natural killer cell mediated cytotoxicity  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
prostate gland epithelium morphogenesis  (ISO)
receptor signaling pathway via JAK-STAT  (ISO)
reelin-mediated signaling pathway  (ISO)
regulation of cell adhesion  (ISO)
regulation of epithelial cell differentiation  (ISO)
regulation of multicellular organism growth  (ISO)
regulation of steroid metabolic process  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
response to ethanol  (ISO)
response to nutrient levels  (ISO)
response to peptide hormone  (ISO)
T cell differentiation in thymus  (ISO)
T cell homeostasis  (ISO)
taurine metabolic process  (ISO)
transcription by RNA polymerase II  (ISO)

Cellular Component
cytoplasm  (ISO)
cytosol  (ISO)
nucleoplasm  (ISO)
nucleus  (ISO)

References

Genomics

Comparative Map Data
LOC100988550
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11715,228,465 - 15,251,783 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1715,228,465 - 15,251,783 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01715,005,025 - 15,029,110 (-)NCBIMhudiblu_PPA_v0panPan3
STAT5A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1742,287,547 - 42,311,943 (+)EnsemblGRCh38hg38GRCh38
GRCh381742,287,547 - 42,311,943 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371740,439,565 - 40,463,961 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361737,693,091 - 37,717,484 (+)NCBINCBI36hg18NCBI36
Build 341737,693,090 - 37,717,484NCBI
Celera1737,094,449 - 37,118,845 (+)NCBI
Cytogenetic Map17q21.2NCBI
HuRef1736,204,247 - 36,228,642 (+)NCBIHuRef
CHM1_11740,675,279 - 40,699,663 (+)NCBICHM1_1
Stat5a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911100,750,177 - 100,775,995 (+)NCBIGRCm39mm39
GRCm39 Ensembl11100,750,177 - 100,775,995 (+)Ensembl
GRCm3811100,859,351 - 100,885,169 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11100,859,351 - 100,885,169 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711100,720,665 - 100,746,483 (+)NCBIGRCm37mm9NCBIm37
MGSCv3611100,675,494 - 100,701,259 (+)NCBImm8
MGSCv3611101,635,936 - 101,661,700 (+)NCBImm8
Cytogenetic Map11DNCBI
cM Map1163.77NCBI
Stat5a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21085,785,537 - 85,809,869 (+)NCBI
Rnor_6.0 Ensembl1088,764,732 - 88,789,057 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01088,764,732 - 88,789,060 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01088,558,936 - 88,583,264 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41089,795,404 - 89,819,732 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11089,809,773 - 89,834,099 (+)NCBI
Celera1084,503,376 - 84,527,708 (+)NCBICelera
Cytogenetic Map10q31NCBI
Stat5a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545116,305,363 - 16,319,219 (+)NCBIChiLan1.0ChiLan1.0
STAT5A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,616,041 - 20,638,523 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl920,617,151 - 20,638,103 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha920,077,547 - 20,099,955 (-)NCBI
ROS_Cfam_1.0921,335,685 - 21,357,957 (-)NCBI
UMICH_Zoey_3.1920,120,814 - 20,142,574 (-)NCBI
UNSW_CanFamBas_1.0920,387,762 - 20,409,305 (-)NCBI
UU_Cfam_GSD_1.0920,490,411 - 20,512,845 (-)NCBI
STAT5A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,474,225 - 20,499,138 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11220,474,221 - 20,498,785 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21224,563,982 - 24,581,115 (+)NCBISscrofa10.2Sscrofa10.2susScr3
STAT5A
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11663,959,265 - 63,986,627 (-)NCBI
ChlSab1.1 Ensembl1663,960,515 - 63,985,026 (-)Ensembl
Vero_WHO_p1.0NW_02366607734,770,565 - 34,795,956 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000061773   ⟹   ENSPPAP00000038864
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1715,228,465 - 15,251,783 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000061775   ⟹   ENSPPAP00000038866
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1715,228,465 - 15,251,595 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000061811   ⟹   ENSPPAP00000038902
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1715,229,735 - 15,250,227 (-)Ensembl
RefSeq Acc Id: XM_003813880   ⟹   XP_003813928
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11715,228,465 - 15,251,783 (-)NCBI
Mhudiblu_PPA_v01715,005,025 - 15,029,110 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008966485   ⟹   XP_008964733
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11715,228,465 - 15,251,595 (-)NCBI
Mhudiblu_PPA_v01715,005,025 - 15,028,602 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034941834   ⟹   XP_034797725
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01715,005,389 - 15,028,196 (-)NCBI
Protein Sequences
Protein RefSeqs XP_003813928 (Get FASTA)   NCBI Sequence Viewer  
  XP_008964733 (Get FASTA)   NCBI Sequence Viewer  
  XP_034797725 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003813928   ⟸   XM_003813880
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008964733   ⟸   XM_008966485
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_034797725   ⟸   XM_034941834
- Peptide Label: isoform X3
RefSeq Acc Id: ENSPPAP00000038866   ⟸   ENSPPAT00000061775
RefSeq Acc Id: ENSPPAP00000038864   ⟸   ENSPPAT00000061773
RefSeq Acc Id: ENSPPAP00000038902   ⟸   ENSPPAT00000061811
Protein Domains
SH2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000042087 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000038864 UniProtKB/TrEMBL
  ENSPPAP00000038866 UniProtKB/TrEMBL
  ENSPPAP00000038902 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000061773 UniProtKB/TrEMBL
  ENSPPAT00000061775 UniProtKB/TrEMBL
  ENSPPAT00000061811 UniProtKB/TrEMBL
Gene3D-CATH 1.10.532.10 UniProtKB/TrEMBL
  2.60.40.630 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
InterPro p53-like_TF_DNA-bd UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  STAT UniProtKB/TrEMBL
  STAT5a/5b UniProtKB/TrEMBL
  STAT_N_sf UniProtKB/TrEMBL
  STAT_TF_alpha UniProtKB/TrEMBL
  STAT_TF_coiled-coil UniProtKB/TrEMBL
  STAT_TF_DNA-bd UniProtKB/TrEMBL
  STAT_TF_DNA-bd_N UniProtKB/TrEMBL
  STAT_TF_prot_interaction UniProtKB/TrEMBL
KEGG Report pps:100988550 UniProtKB/TrEMBL
NCBI Gene STAT5A ENTREZGENE
PANTHER PTHR11801 UniProtKB/TrEMBL
  PTHR11801:SF47 UniProtKB/TrEMBL
Pfam SH2 UniProtKB/TrEMBL
  STAT_alpha UniProtKB/TrEMBL
  STAT_bind UniProtKB/TrEMBL
  STAT_int UniProtKB/TrEMBL
PROSITE SH2 UniProtKB/TrEMBL
SMART SH2 UniProtKB/TrEMBL
  STAT_int UniProtKB/TrEMBL
Superfamily-SCOP SSF47655 UniProtKB/TrEMBL
  SSF48092 UniProtKB/TrEMBL
  SSF49417 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A0A2R9CAA2_PANPA UniProtKB/TrEMBL
  A0A2R9CAH7_PANPA UniProtKB/TrEMBL
  A0A2R9CL64_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-07-01 LOC100988550  signal transducer and activator of transcription 5A  STAT5A  signal transducer and activator of transcription 5A  Symbol and/or name change 5135510 APPROVED