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Gene: GDF15 (growth differentiation factor 15) Pan paniscus

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Symbol:

GDF15

Name:

growth differentiation factor 15

RGD ID:

11980308

Description:

ENCODES a protein that exhibits cytokine activity (inferred); growth factor activity (inferred); hormone activity (inferred); INVOLVED IN positive regulation of myoblast fusion (ortholog); ASSOCIATED WITH anemia (ortholog); Cachexia (ortholog); congestive heart failure (ortholog); FOUND IN extracellular space (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

growth/differentiation factor 15

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	23,235,317 - 23,249,754 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	22,255,036 - 22,258,089 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	17,864,840 - 17,867,883 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	18,835,216 - 18,838,470 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	18,835,216 - 18,838,470 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

anemia (ISO)

Cachexia (ISO)

congestive heart failure (ISO)

coronary artery disease (ISO)

Gastrointestinal Neoplasms (ISO)

hepatocellular carcinoma (ISO)

Hyperemesis Gravidarum (ISO)

Left Ventricular Hypertrophy (ISO)

Megalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 1 (ISO)

melanoma (ISO)

mouth disease (ISO)

Myocardial Ischemia (ISO)

Neoplasm Metastasis (ISO)

Prostatic Neoplasms (ISO)

sideroblastic anemia (ISO)

Weight Gain (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to chemical stress (IEA)

energy homeostasis (IEA)

GDF15-GFRAL signaling pathway (IEA)

negative regulation of appetite (IEA)

negative regulation of growth hormone receptor signaling pathway (IEA)

negative regulation of leukocyte migration (IEA)

negative regulation of multicellular organism growth (IEA)

negative regulation of SMAD protein signal transduction (IEA)

negative regulation of transforming growth factor beta receptor signaling pathway (IEA)

positive regulation of fatty acid oxidation (IEA)

positive regulation of MAPK cascade (IEA)

positive regulation of myoblast fusion (IEA,ISO)

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (IEA)

reduction of food intake in response to dietary excess (IEA)

response to metformin (IEA)

Cellular Component

cytoplasm (IEA)

extracellular region (IEA)

extracellular space (IEA,ISO)

Golgi apparatus (IEA)

nucleus (IEA)

Molecular Function

cytokine activity (IEA)

growth factor activity (IEA)

hormone activity (IEA)

protein binding (ISO)

protein homodimerization activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

GDF15
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	23,235,317 - 23,249,754 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	22,255,036 - 22,258,089 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	17,864,840 - 17,867,883 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	18,835,216 - 18,838,470 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	18,835,216 - 18,838,470 (+)	Ensembl	panpan1.1		panPan2

GDF15
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	18,386,158 - 18,389,176 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	18,374,731 - 18,389,176 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	18,496,968 - 18,499,986 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	18,357,968 - 18,360,986 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	18,357,984 - 18,360,986	NCBI
Celera	19	18,398,797 - 18,401,815 (+)	NCBI		Celera
Cytogenetic Map	19	p13.11	NCBI
HuRef	19	18,062,378 - 18,063,268 (+)	NCBI		HuRef
CHM1_1	19	18,497,209 - 18,500,231 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	18,515,920 - 18,523,324 (+)	NCBI		T2T-CHM13v2.0

Gdf15
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	71,082,043 - 71,085,106 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	71,082,043 - 71,085,106 (-)	Ensembl		GRCm39 Ensembl
GRCm38	8	70,629,393 - 70,632,470 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	70,629,393 - 70,632,456 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	73,153,293 - 73,155,534 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	73,558,382 - 73,561,082 (-)	NCBI		MGSCv36	mm8
Celera	8	73,186,175 - 73,188,416 (-)	NCBI		Celera
Cytogenetic Map	8	B3.3	NCBI
cM Map	8	34.15	NCBI

Gdf15
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	18,838,436 - 18,842,022 (+)	NCBI		GRCr8
mRatBN7.2	16	18,804,457 - 18,808,043 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	18,805,239 - 18,808,055 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	18,847,005 - 18,849,564 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	19,979,943 - 19,982,528 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	18,899,963 - 18,902,522 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	20,555,395 - 20,557,978 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	20,555,395 - 20,557,978 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	20,411,167 - 20,413,750 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	19,310,882 - 19,313,465 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	19,310,851 - 19,313,463 (+)	NCBI
Celera	16	18,997,242 - 18,999,829 (+)	NCBI		Celera
Cytogenetic Map	16	p14	NCBI

Gdf15
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955524	3,123,760 - 3,125,621 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955524	3,123,513 - 3,125,642 (-)	NCBI	ChiLan1.0	ChiLan1.0

GDF15
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	44,633,131 - 44,636,842 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	44,634,588 - 44,636,821 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	44,547,490 - 44,551,239 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	45,119,086 - 45,122,834 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	45,120,542 - 45,122,775 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	44,356,357 - 44,360,107 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	44,766,491 - 44,770,241 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	45,041,907 - 45,045,657 (-)	NCBI		UU_Cfam_GSD_1.0

Gdf15
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	203,305,463 - 203,310,650 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936596	2,854,841 - 2,857,111 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936596	2,854,620 - 2,857,018 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GDF15
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	59,408,904 - 59,411,358 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	59,409,035 - 59,411,356 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

GDF15
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	16,853,397 - 16,861,924 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	16,852,971 - 16,861,964 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666074	2,479,299 - 2,485,699 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gdf15
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624908	1,634,174 - 1,636,242 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624908	1,633,927 - 1,636,242 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008971034	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000054005 ⟹ ENSPPAP00000031141

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	19	18,835,216 - 18,838,470 (+)	Ensembl

RefSeq Acc Id:

XM_008971034 ⟹ XP_008969282

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	20	23,235,317 - 23,249,754 (+)	NCBI
NHGRI_mPanPan1	19	22,255,036 - 22,258,089 (+)	NCBI
Mhudiblu_PPA_v0	19	17,864,840 - 17,867,883 (+)	NCBI
PanPan1.1	19	18,835,216 - 18,838,470 (+)	NCBI

Sequence:

show sequence

ACTCCCAGGCTGGAATGGTGTCCTCATATGGAGGAAGAGGATACTGAGGCCCAGAAATGTGCCC
TAGCTTTACTAGGAGCGCCCCCACCTAAAGATCCTCCCCCTAAATACACCCCCAGACCCCGCCC
AGCTGTGGTCATTGGAGTGTTTACTCTGCAGGCAGGGGGAGGAGGGCGGGACTGAGCAGGCGGA
GACGGACAAAGACCGGGGACTATAAAGGCCGGTCCGGCAGCATCTGGTCAGTCCCAGCTCAGAG
CCGCAACCGGCACAGCCATGCCCAGGCAAGAACTCAGGACGCTGAATGGCTCTCAGATGCTCCT
GGTGTTGCTGGTGCTCTCGTGGCCGCCGCATGGGGGCGCCCTGTCTCTGGCCGAGGCGAGCCGC
GCAAGTTTCTCGGGACCCTCTGAGTTGCACTCCGAAGACGCCAGATTCCGAGAGTTGCGGAAAC
GCTACGAGGACCTGCTGACCAGGCTGCGGGCCAACCAGAGCTGGGAAGATTCAAACACCGACCT
CGTCCCGGCCCCTGCAGTCCGGATACTCACGCCGGAAGTGCGGCTGGGATCTGGCGGCCACCTG
CACCTGCGTATCTCCCGGGCCGCCCTTCCCGAGGGGCTCCCCGAGGCCTCCCGCCTTCACCGGG
CTCTGTTCCGGCTGTCCCCGACGGCGGCAAGGTCGTGGGACGTGACACGACCGCTGCGGCGTCA
GCTCAGCCTTGCAAGACCCCAGGCGCCCGCGCTGCACCTGCGACTGTCGCCGCCGCCGTCGCAG
TCTGACCAACTGCTGGCAGAATCTTCGTCCGCACGGCCCCAGCTGGAGTTGCACTTGCGGTCGC
GAGCCGCCAGGGGGCTCCGCAGAGCGCGTGCGAGCAACGGGGACCACTGTCCGCTCGGGCCCGG
GCGCTGCTGCCGTCTGCACACGGTCCGCGCGTCGCTGGAAGACCTGGGCTGGTCCGATTGGGTG
CTGTCGCCACGGGAGGTGCAAGTGACCATGTGCATCGGCGCGTGCCCGAGCCAGTTCCGGGCGG
CAAACATGCACGCGCAGATCAAGACGAGCCTGCACCGCCTGAAGCCCGACACGGTGCCAGCGCC
CTGCTGCGTGCCCGCCAGCTACAATCCCATGGTGCTCATTCAAAAGACCGACACCGGGGTGTCG
CTCCAGACCTATGATGACTTGTTAGCCAAAGACTGCCACTGCATATGAGCAGCCCTGGTCCTTC
CACTGTGCACCTGCGCGGGGGACGCGACCTCAGTTGTCCTGTCCTGTGGAATGGGCTCAAGGTT
CCTGAGACACCCGATTCCTGCCCAAACAGCTGTATTTATATAAGTCTGTTATTTATTATTAATT
TATTGGGGTGACCTTCTTGGGGACTGGGGGTCTGGTCTGATGGAACTGTGTATTTATTTAAAAC
TCTGGTGATAAAAATAAAGCTGTCTGAACTGTT

hide sequence

Protein Sequences


Protein RefSeqs	XP_008969282	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000031141.1

RefSeq Acc Id:

XP_008969282 ⟸ XM_008971034

- UniProtKB:

A0A2R9BNA9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPRQELRTLNGSQMLLVLLVLSWPPHGGALSLAEASRASFSGPSELHSEDARFRELRKRYEDLL
TRLRANQSWEDSNTDLVPAPAVRILTPEVRLGSGGHLHLRISRAALPEGLPEASRLHRALFRLS
PTAARSWDVTRPLRRQLSLARPQAPALHLRLSPPPSQSDQLLAESSSARPQLELHLRSRAARGL
RRARASNGDHCPLGPGRCCRLHTVRASLEDLGWSDWVLSPREVQVTMCIGACPSQFRAANMHAQ
IKTSLHRLKPDTVPAPCCVPASYNPMVLIQKTDTGVSLQTYDDLLAKDCHCI

hide sequence

Ensembl Acc Id:

ENSPPAP00000031141 ⟸ ENSPPAT00000054005

Protein Domains

TGF-beta family profile

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000038519	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000054005.1	UniProtKB/TrEMBL
Gene3D-CATH	2.10.90.10	UniProtKB/TrEMBL
InterPro	Cystine-knot_cytokine	UniProtKB/TrEMBL
	TGF-b_C	UniProtKB/TrEMBL
	TGF-beta-rel	UniProtKB/TrEMBL
KEGG Report	pps:100976345	UniProtKB/TrEMBL
NCBI Gene	GDF15	ENTREZGENE
PANTHER	GROWTH/DIFFERENTIATION FACTOR 15	UniProtKB/TrEMBL
	PTHR11848	UniProtKB/TrEMBL
Pfam	TGF_beta	UniProtKB/TrEMBL
PROSITE	TGF_BETA_2	UniProtKB/TrEMBL
SMART	TGFB	UniProtKB/TrEMBL
Superfamily-SCOP	SSF57501	UniProtKB/TrEMBL
UniProt	A0A2R9BNA9	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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