RGD Reference Report - Relationship between adipokines and coronary artery aneurysm in children with Kawasaki disease. - Rat Genome Database

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Relationship between adipokines and coronary artery aneurysm in children with Kawasaki disease.

Authors: Liu, R  He, B  Gao, F  Liu, Q  Yi, Q 
Citation: Liu R, etal., Transl Res. 2012 Aug;160(2):131-6. doi: 10.1016/j.trsl.2012.01.013. Epub 2012 Feb 2.
RGD ID: 8694456
Pubmed: PMID:22683371   (View Abstract at PubMed)
DOI: DOI:10.1016/j.trsl.2012.01.013   (Journal Full-text)

Body fat is an important source of adipokines not only in association with energy balance, but also with inflammatory and immune responses. This study investigated the relationship between serum levels of adipokines and coronary artery aneurysm in patients with Kawasaki disease (KD). Levels of leptin, adiponectin, and resistin were measured in 165 cases, including 4 groups: the control group (n = 85), KD with normal coronary arteries (n = 41), KD with dilatation and/or ectasia (n = 31), and KD with coronary aneurysm (n = 8). White blood cells counts (WBC), red blood cells counts (RBC), hemoglobin (HB), Hematocrit (Hct), platelet count, C reactive protein (CRP), and erythrocyte sedimentation rate (ESR) were tested in children. Levels of adiponectin and resistin levels were significantly elevated; hemoglobin significantly decreased in the group of KD with coronary aneurysm compared with the controls or other KD subgroups. There were markedly positive relationships between levels of resistin and CRP, and negative relationships between levels of resistin and RBC in patients with KD. Levels of adiponectin, resistin, and hemoglobin were associated with the development of coronary aneurysm in children with KD. The up-regulation of resistin secreted from adipose tissue may be closely linked to up-regulation of systemic proinflammatory markers in acute KD.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ADIPOQHumancoronary aneurysm  IEP associated with Mucocutaneous Lymph Node Syndrome and protein:increased expression:serumRGD 
AdipoqRatcoronary aneurysm  ISOADIPOQ (Homo sapiens)associated with Mucocutaneous Lymph Node Syndrome and protein:increased expression:serumRGD 
AdipoqMousecoronary aneurysm  ISOADIPOQ (Homo sapiens)associated with Mucocutaneous Lymph Node Syndrome and protein:increased expression:serumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Adipoq  (adiponectin, C1Q and collagen domain containing)

Genes (Mus musculus)
Adipoq  (adiponectin, C1Q and collagen domain containing)

Genes (Homo sapiens)
ADIPOQ  (adiponectin, C1Q and collagen domain containing)


Additional Information