RHOA (ras homolog family member A) - Rat Genome Database
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Gene: RHOA (ras homolog family member A) Pan paniscus
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Symbol: RHOA
Name: ras homolog family member A
RGD ID: 11748716
Description: ENCODES a protein that exhibits GDP binding (ortholog); GTP binding (ortholog); GTPase activity (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); actin cytoskeleton reorganization (ortholog); alpha-beta T cell lineage commitment (ortholog); PARTICIPATES IN calcium signaling pathway via the calcium-sensing receptor; E-cadherin signaling pathway; eicosanoid signaling pathway; ASSOCIATED WITH Abnormalities, Drug-Induced (ortholog); alopecia (ortholog); Animal Disease Models (ortholog); FOUND IN apical junction complex (ortholog); axon (ortholog); cell cortex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: transforming protein RhoA
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1350,362,698 - 50,584,600 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0349,282,009 - 49,339,887 (-)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Abnormalities, Drug-Induced  (ISO)
alopecia  (ISO)
Animal Disease Models  (ISO)
asthma  (ISO)
autosomal recessive limb-girdle muscular dystrophy type 2P  (ISO)
Brain Injuries  (ISO)
breast cancer  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
Cardiomegaly  (ISO)
Cocaine-Related Disorders  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
congenital diaphragmatic hernia  (ISO)
Craniofacial Abnormalities  (ISO)
cutaneous T cell lymphoma  (ISO)
ectodermal dysplasia  (ISO)
esophageal carcinoma  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
Facial Ectodermal Dysplasia  (ISO)
fetal alcohol syndrome  (ISO)
Fibrosis  (ISO)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
Germ Cell and Embryonal Neoplasms  (ISO)
head and neck squamous cell carcinoma  (ISO)
hypertension  (ISO)
Hypopigmentation  (ISO)
Immunoblastic Lymphadenopathy  (ISO)
Left Ventricular Hypertrophy  (ISO)
Leukoencephalopathies  (ISO)
lung adenocarcinoma  (ISO)
Lymphatic Metastasis  (ISO)
membranous glomerulonephritis  (ISO)
multiple sclerosis  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neurocutaneous Syndromes  (ISO)
non-Hodgkin lymphoma  (ISO)
obesity  (ISO)
Optic Nerve Injuries  (ISO)
ovarian carcinoma  (ISO)
peripheral T-cell lymphoma  (ISO)
proteinuria  (ISO)
pulmonary hypertension  (ISO)
Stomach Neoplasms  (ISO)
T-Cell Lymphoma  (ISO)
tooth disease  (ISO)
urinary bladder cancer  (ISO)
Urologic Neoplasms  (ISO)
withdrawal disorder  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (ISO)
actin cytoskeleton reorganization  (ISO)
alpha-beta T cell lineage commitment  (ISO)
androgen receptor signaling pathway  (ISO)
angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure  (ISO)
apical junction assembly  (ISO)
apolipoprotein A-I-mediated signaling pathway  (ISO)
beta selection  (ISO)
cell adhesion  (ISO)
cell differentiation  (ISO)
cell junction assembly  (ISO)
cell migration  (ISO)
cell morphogenesis  (ISO)
cell-matrix adhesion  (ISO)
cellular response to chemokine  (ISO)
cellular response to cytokine stimulus  (ISO)
cellular response to lipopolysaccharide  (ISO)
cerebral cortex cell migration  (ISO)
cleavage furrow formation  (ISO)
cytoplasmic microtubule organization  (ISO)
cytoskeleton organization  (ISO)
embryonic cleavage  (ISO)
endothelial cell migration  (ISO)
endothelial tube lumen extension  (ISO)
establishment of epithelial cell apical/basal polarity  (ISO)
establishment or maintenance of actin cytoskeleton polarity  (ISO)
forebrain radial glial cell differentiation  (ISO)
GTP metabolic process  (ISO)
kidney development  (ISO)
meiotic spindle organization  (ISO)
mitotic cleavage furrow formation  (ISO)
mitotic spindle assembly  (ISO)
negative chemotaxis  (ISO)
negative regulation of cell death  (ISO)
negative regulation of cell migration involved in sprouting angiogenesis  (ISO)
negative regulation of cell size  (ISO)
negative regulation of cell-substrate adhesion  (ISO)
negative regulation of I-kappaB kinase/NF-kappaB signaling  (ISO)
negative regulation of intracellular steroid hormone receptor signaling pathway  (ISO)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of neuron differentiation  (ISO)
negative regulation of neuron projection development  (ISO)
negative regulation of oxidative phosphorylation  (ISO)
negative regulation of reactive oxygen species biosynthetic process  (ISO)
neuron projection morphogenesis  (ISO)
odontogenesis  (ISO)
ossification involved in bone maturation  (ISO)
polar body extrusion after meiotic divisions  (ISO)
positive regulation of actin filament polymerization  (ISO)
positive regulation of alpha-beta T cell differentiation  (ISO)
positive regulation of cell adhesion  (ISO)
positive regulation of cell growth  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
positive regulation of cytokinesis  (ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (ISO)
positive regulation of leukocyte adhesion to vascular endothelial cell  (ISO)
positive regulation of lipase activity  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of NIK/NF-kappaB signaling  (ISO)
positive regulation of podosome assembly  (ISO)
positive regulation of protein serine/threonine kinase activity  (ISO)
positive regulation of smooth muscle contraction  (ISO)
positive regulation of stress fiber assembly  (ISO)
positive regulation of T cell migration  (ISO)
positive regulation of translation  (ISO)
positive regulation of vascular associated smooth muscle contraction  (ISO)
positive regulation of vasoconstriction  (ISO)
regulation of actin cytoskeleton organization  (ISO)
regulation of actin polymerization or depolymerization  (ISO)
regulation of calcium ion transport  (ISO)
regulation of cell migration  (ISO)
regulation of dendrite development  (ISO)
regulation of microtubule cytoskeleton organization  (ISO)
regulation of modification of postsynaptic actin cytoskeleton  (ISO)
regulation of modification of synaptic structure  (ISO)
regulation of neural precursor cell proliferation  (ISO)
regulation of neuron projection development  (ISO)
regulation of osteoblast proliferation  (ISO)
regulation of systemic arterial blood pressure by endothelin  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
response to amino acid  (ISO)
response to drug  (ISO)
response to ethanol  (ISO)
response to glucocorticoid  (ISO)
response to glucose  (ISO)
response to hypoxia  (ISO)
response to mechanical stimulus  (ISO)
Rho protein signal transduction  (ISO)
Roundabout signaling pathway  (ISO)
skeletal muscle tissue development  (ISO)
spindle localization  (ISO)
stress fiber assembly  (ISO)
stress-activated protein kinase signaling cascade  (ISO)
substantia nigra development  (ISO)
substrate adhesion-dependent cell spreading  (ISO)
trabecula morphogenesis  (ISO)

Cellular Component

Molecular Function

References

Genomics

Comparative Map Data
RHOA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1350,362,698 - 50,584,600 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0349,282,009 - 49,339,887 (-)NCBIMhudiblu_PPA_v0panPan3
RHOA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl349,359,139 - 49,412,998 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl349,359,145 - 49,412,998 (-)EnsemblGRCh38hg38GRCh38
GRCh38349,359,145 - 49,411,976 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37349,396,578 - 49,449,409 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36349,371,582 - 49,424,530 (-)NCBINCBI36hg18NCBI36
Build 34349,371,584 - 49,424,530NCBI
Celera349,361,450 - 49,414,313 (-)NCBI
Cytogenetic Map3p21.31NCBI
HuRef349,456,057 - 49,509,248 (-)NCBIHuRef
CHM1_1349,349,379 - 49,402,297 (-)NCBICHM1_1
Rhoa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399108,183,359 - 108,215,142 (+)NCBIGRCm39mm39
GRCm39 Ensembl9108,183,328 - 108,215,133 (+)Ensembl
GRCm389108,306,160 - 108,337,943 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9108,306,129 - 108,337,934 (+)EnsemblGRCm38mm10GRCm38
MGSCv379108,208,536 - 108,240,270 (+)NCBIGRCm37mm9NCBIm37
MGSCv369108,164,298 - 108,196,026 (+)NCBImm8
Celera9107,915,249 - 107,947,041 (+)NCBICelera
Cytogenetic Map9F2NCBI
Rhoa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28108,991,926 - 109,025,746 (+)NCBI
Rnor_6.0 Ensembl8117,106,576 - 117,116,167 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.08117,082,440 - 117,116,244 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08116,431,244 - 116,464,932 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera8108,319,010 - 108,327,586 (+)NCBICelera
Cytogenetic Map8q32NCBI
Rhoa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555321,300,462 - 1,347,451 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555321,300,821 - 1,347,453 (-)NCBIChiLan1.0ChiLan1.0
RHOA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2039,824,575 - 39,887,215 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12039,824,552 - 39,888,089 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Rhoa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365291,000,050 - 1,045,655 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RHOA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1331,918,836 - 32,003,722 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11331,918,484 - 31,991,207 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21335,149,494 - 35,160,516 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RHOA
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12210,757,381 - 10,809,257 (-)NCBI
ChlSab1.1 Ensembl2210,757,337 - 10,772,704 (-)Ensembl
Rhoa
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247303,316,122 - 3,361,820 (-)NCBI


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003818369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide SSBP01000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: XM_003818369   ⟹   XP_003818417
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1350,362,698 - 50,584,600 (-)NCBI
Mhudiblu_PPA_v0349,282,009 - 49,339,887 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003818417 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003818417   ⟸   XM_003818369
- Sequence:


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000031493 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000016797 ENTREZGENE, UniProtKB/TrEMBL
  ENSPPAP00000016812 UniProtKB/TrEMBL
  ENSPPAP00000016816 UniProtKB/TrEMBL
  ENSPPAP00000016817 UniProtKB/TrEMBL
  ENSPPAP00000016820 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000039495 UniProtKB/TrEMBL
  ENSPPAT00000039511 UniProtKB/TrEMBL
  ENSPPAT00000039515 UniProtKB/TrEMBL
  ENSPPAT00000039516 UniProtKB/TrEMBL
  ENSPPAT00000039519 UniProtKB/TrEMBL
InterPro P-loop_NTPase UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/TrEMBL
  Small_GTPase UniProtKB/TrEMBL
  Small_GTPase_Rho UniProtKB/TrEMBL
KEGG Report pps:100995642 UniProtKB/TrEMBL
NCBI Gene RHOA ENTREZGENE
Pfam Ras UniProtKB/TrEMBL
PROSITE RHO UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
TIGRFAMs small_GTP UniProtKB/TrEMBL
UniProt A0A2R9AHH0_PANPA UniProtKB/TrEMBL
  A0A2R9AHI6_PANPA UniProtKB/TrEMBL
  A0A2R9AHJ1_PANPA UniProtKB/TrEMBL
  A0A2R9AHJ2_PANPA UniProtKB/TrEMBL
  A0A2R9AMA2_PANPA UniProtKB/TrEMBL