RHOA (ras homolog family member A) - Rat Genome Database

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Gene: RHOA (ras homolog family member A) Pan paniscus
Analyze
Symbol: RHOA
Name: ras homolog family member A
RGD ID: 11748716
Description: ENCODES a protein that exhibits GDP binding (ortholog); GTP binding (ortholog); myosin binding (ortholog); INVOLVED IN actin cytoskeleton organization (ortholog); androgen receptor signaling pathway (ortholog); angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure (ortholog); PARTICIPATES IN calcium signaling pathway via the calcium-sensing receptor; E-cadherin signaling pathway; eicosanoid signaling pathway; ASSOCIATED WITH Abnormalities, Drug-Induced (ortholog); acute myocardial infarction (ortholog); Aicardi-Goutieres Syndrome 1 (ortholog); FOUND IN apical junction complex (ortholog); axon (ortholog); cell cortex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: transforming protein RhoA
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2249,336,475 - 49,394,257 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1349,341,246 - 49,398,996 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0349,282,009 - 49,339,887 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1350,362,698 - 50,584,600 (-)NCBIpanpan1.1PanPan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Abnormalities, Drug-Induced  (ISO)
acute myocardial infarction  (ISO)
Aicardi-Goutieres Syndrome 1  (ISO)
alopecia  (ISO)
Animal Disease Models  (ISO)
asthma  (ISO)
autosomal recessive limb-girdle muscular dystrophy type 2P  (ISO)
Brain Injuries  (ISO)
breast cancer  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
Cardiomegaly  (ISO)
carnitine-acylcarnitine translocase deficiency  (ISO)
Cocaine-Related Disorders  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
congenital diaphragmatic hernia  (ISO)
Craniofacial Abnormalities  (ISO)
Diabetic Nephropathies  (ISO)
ectodermal dysplasia  (ISO)
ECTODERMAL DYSPLASIA WITH FACIAL DYSMORPHISM AND ACRAL, OCULAR, AND BRAIN ANOMALIES  (ISO)
esophageal carcinoma  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
fetal alcohol syndrome  (ISO)
Fibrosis  (ISO)
gastric adenocarcinoma  (ISO)
genetic disease  (ISO)
Germ Cell and Embryonal Neoplasms  (ISO)
glycine encephalopathy  (ISO)
head and neck squamous cell carcinoma  (ISO)
hypertension  (ISO)
Hypopigmentation  (ISO)
Immunoblastic Lymphadenopathy  (ISO)
Left Ventricular Hypertrophy  (ISO)
Leukoencephalopathies  (ISO)
lung adenocarcinoma  (ISO)
Lymphatic Metastasis  (ISO)
membranous glomerulonephritis  (ISO)
multiple sclerosis  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
Neurocutaneous Syndromes  (ISO)
non-Hodgkin lymphoma  (ISO)
obesity  (ISO)
Optic Nerve Injuries  (ISO)
ovarian carcinoma  (ISO)
peripheral T-cell lymphoma  (ISO)
Pierson syndrome  (ISO)
primary cutaneous T-cell non-Hodgkin lymphoma  (ISO)
proteinuria  (ISO)
pulmonary hypertension  (ISO)
Spinal Cord Injuries  (ISO)
Stomach Neoplasms  (ISO)
T-cell non-Hodgkin lymphoma  (ISO)
tooth disease  (ISO)
urinary bladder cancer  (ISO)
Urologic Neoplasms  (ISO)
withdrawal disorder  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (IEA,ISO)
alpha-beta T cell lineage commitment  (IEA)
androgen receptor signaling pathway  (IEA,ISO)
angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure  (IEA,ISO)
aortic valve formation  (ISO)
apical junction assembly  (IEA)
apolipoprotein A-I-mediated signaling pathway  (ISO)
beta selection  (IEA)
bone trabecula morphogenesis  (IEA)
cell adhesion  (IEA,ISO)
cell differentiation  (IEA,ISO)
cell junction assembly  (ISO)
cell migration  (ISO)
cell morphogenesis  (IEA,ISO)
cell-matrix adhesion  (IEA,ISO)
cellular response to chemokine  (ISO)
cellular response to cytokine stimulus  (ISO)
cellular response to lipopolysaccharide  (ISO)
cerebral cortex cell migration  (IEA,ISO)
cleavage furrow formation  (ISO)
cytoplasmic microtubule organization  (ISO)
cytoskeleton organization  (IEA,ISO)
embryonic cleavage  (ISO)
endothelial cell migration  (ISO)
endothelial tube lumen extension  (ISO)
establishment of epithelial cell apical/basal polarity  (ISO)
establishment or maintenance of actin cytoskeleton polarity  (ISO)
forebrain radial glial cell differentiation  (IEA,ISO)
GTP metabolic process  (ISO)
kidney development  (IEA,ISO)
meiotic spindle organization  (ISO)
microtubule depolymerization  (ISO)
mitotic cleavage furrow formation  (ISO)
mitotic spindle assembly  (ISO)
motor neuron apoptotic process  (IEA,ISO)
negative chemotaxis  (ISO)
negative regulation of canonical NF-kappaB signal transduction  (ISO)
negative regulation of cell migration involved in sprouting angiogenesis  (ISO)
negative regulation of cell size  (ISO)
negative regulation of cell-substrate adhesion  (IEA)
negative regulation of intracellular steroid hormone receptor signaling pathway  (IEA,ISO)
negative regulation of motor neuron apoptotic process  (IEA,ISO)
negative regulation of neuron differentiation  (ISO)
negative regulation of neuron projection development  (ISO)
negative regulation of oxidative phosphorylation  (IEA)
negative regulation of reactive oxygen species biosynthetic process  (IEA)
negative regulation of synapse assembly  (ISO)
negative regulation of vascular associated smooth muscle cell migration  (ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (ISO)
neuron migration  (IEA,ISO)
neuron projection morphogenesis  (ISO)
odontogenesis  (IEA)
ossification involved in bone maturation  (IEA)
polar body extrusion after meiotic divisions  (ISO)
positive regulation of actin filament polymerization  (ISO)
positive regulation of alpha-beta T cell differentiation  (IEA)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of cell adhesion  (ISO)
positive regulation of cell growth  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
positive regulation of cytokinesis  (ISO)
positive regulation of leukocyte adhesion to vascular endothelial cell  (ISO)
positive regulation of lipase activity  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of neuron differentiation  (ISO)
positive regulation of podosome assembly  (IEA,ISO)
positive regulation of protein serine/threonine kinase activity  (ISO)
positive regulation of smooth muscle contraction  (ISO)
positive regulation of stress fiber assembly  (IEA,ISO)
positive regulation of T cell migration  (ISO)
positive regulation of translation  (ISO)
positive regulation of vascular associated smooth muscle contraction  (IEA,ISO)
positive regulation of vasoconstriction  (ISO)
regulation of actin cytoskeleton organization  (IEA)
regulation of actin polymerization or depolymerization  (ISO)
regulation of calcium ion transport  (ISO)
regulation of cell migration  (ISO)
regulation of dendrite development  (ISO)
regulation of microtubule cytoskeleton organization  (IEA)
regulation of modification of postsynaptic actin cytoskeleton  (ISO)
regulation of modification of postsynaptic structure  (ISO)
regulation of neural precursor cell proliferation  (IEA,ISO)
regulation of neuron projection development  (IEA,ISO)
regulation of osteoblast proliferation  (IEA)
regulation of systemic arterial blood pressure by endothelin  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IEA,ISO)
response to amino acid  (ISO)
response to ethanol  (ISO)
response to glucocorticoid  (ISO)
response to glucose  (ISO)
response to hypoxia  (ISO)
response to mechanical stimulus  (ISO)
response to xenobiotic stimulus  (ISO)
Rho protein signal transduction  (IEA,ISO)
Roundabout signaling pathway  (ISO)
semaphorin-plexin signaling pathway  (IEA)
skeletal muscle tissue development  (IEA,ISO)
small GTPase-mediated signal transduction  (IEA)
spindle localization  (ISO)
stress fiber assembly  (IEA,ISO)
stress-activated protein kinase signaling cascade  (ISO)
substantia nigra development  (ISO)
substrate adhesion-dependent cell spreading  (ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
RHOA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2249,336,475 - 49,394,257 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1349,341,246 - 49,398,996 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0349,282,009 - 49,339,887 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1350,362,698 - 50,584,600 (-)NCBIpanpan1.1PanPan1.1panPan2
RHOA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38349,359,145 - 49,411,976 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl349,359,139 - 49,412,998 (-)EnsemblGRCh38hg38GRCh38
GRCh37349,396,578 - 49,449,409 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36349,371,582 - 49,424,530 (-)NCBINCBI36Build 36hg18NCBI36
Build 34349,371,584 - 49,424,530NCBI
Celera349,361,450 - 49,414,313 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef349,456,057 - 49,509,248 (-)NCBIHuRef
CHM1_1349,349,388 - 49,402,293 (-)NCBICHM1_1
T2T-CHM13v2.0349,388,518 - 49,441,355 (-)NCBIT2T-CHM13v2.0
Rhoa
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399108,183,359 - 108,215,142 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9108,183,328 - 108,215,133 (+)EnsemblGRCm39 Ensembl
GRCm389108,306,160 - 108,337,943 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9108,306,129 - 108,337,934 (+)EnsemblGRCm38mm10GRCm38
MGSCv379108,208,536 - 108,240,270 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369108,164,298 - 108,196,026 (+)NCBIMGSCv36mm8
Celera9107,915,249 - 107,947,041 (+)NCBICelera
Cytogenetic Map9F2NCBI
cM Map959.2NCBI
Rhoa
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88117,870,548 - 117,904,303 (+)NCBIGRCr8
mRatBN7.28108,991,926 - 109,025,746 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8108,991,954 - 109,025,746 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8114,643,315 - 114,651,893 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08112,842,642 - 112,851,220 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08110,685,281 - 110,693,860 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08117,082,440 - 117,116,244 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,106,576 - 117,116,167 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08116,431,244 - 116,464,932 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera8108,319,010 - 108,327,586 (+)NCBICelera
Cytogenetic Map8q32NCBI
Rhoa
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555321,300,462 - 1,347,451 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555321,300,821 - 1,347,453 (-)NCBIChiLan1.0ChiLan1.0
RHOA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12039,824,552 - 39,888,089 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2039,824,575 - 39,887,215 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2039,743,026 - 39,805,566 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02040,180,779 - 40,244,414 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2040,180,768 - 40,244,414 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12039,548,346 - 39,611,020 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02039,951,968 - 40,014,480 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02040,231,551 - 40,294,267 (+)NCBIUU_Cfam_GSD_1.0
Rhoa
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560264,239,560 - 64,285,154 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936529999,935 - 1,045,681 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365291,000,050 - 1,045,655 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RHOA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1331,918,834 - 31,986,607 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11331,918,484 - 31,991,207 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21335,149,494 - 35,160,516 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RHOA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12210,757,381 - 10,809,257 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2210,757,337 - 10,772,704 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041156,205,022 - 156,258,776 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rhoa
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247303,316,122 - 3,361,820 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Sequence


RefSeq Acc Id: XM_003818369   ⟹   XP_003818417
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2249,336,475 - 49,394,224 (-)NCBI
NHGRI_mPanPan1349,341,246 - 49,398,996 (-)NCBI
Mhudiblu_PPA_v0349,282,009 - 49,339,887 (-)NCBI
PanPan1.1350,362,698 - 50,584,600 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063602359   ⟹   XP_063458429
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2249,338,177 - 49,394,257 (-)NCBI
RefSeq Acc Id: XM_063602360   ⟹   XP_063458430
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2249,339,855 - 49,394,257 (-)NCBI
RefSeq Acc Id: XP_003818417   ⟸   XM_003818369
- Peptide Label: isoform X1
- UniProtKB: A0A2R9AHH0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_063458429   ⟸   XM_063602359
- Peptide Label: isoform X2
- UniProtKB: A0A2R9AHI6 (UniProtKB/TrEMBL),   A0A2R9AHJ2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063458430   ⟸   XM_063602360
- Peptide Label: isoform X3
- UniProtKB: A0A2R9AHJ1 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000031493 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000039495.1 UniProtKB/TrEMBL
  ENSPPAT00000039511.1 UniProtKB/TrEMBL
  ENSPPAT00000039515.1 UniProtKB/TrEMBL
  ENSPPAT00000039516.1 UniProtKB/TrEMBL
  ENSPPAT00000039519.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
InterPro P-loop_NTPase UniProtKB/TrEMBL
  Small_GTP-bd_dom UniProtKB/TrEMBL
  Small_GTPase UniProtKB/TrEMBL
  Small_GTPase_Rho UniProtKB/TrEMBL
KEGG Report pps:100995642 UniProtKB/TrEMBL
NCBI Gene RHOA ENTREZGENE
PANTHER PTHR24072 UniProtKB/TrEMBL
  RAS-LIKE GTP-BINDING PROTEIN RHO1 UniProtKB/TrEMBL
  TRANSFORMING PROTEIN RHOA UniProtKB/TrEMBL
Pfam Ras UniProtKB/TrEMBL
PRINTS RASTRNSFRMNG UniProtKB/TrEMBL
PROSITE RAB UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
SMART RAB UniProtKB/TrEMBL
  RAN UniProtKB/TrEMBL
  RAS UniProtKB/TrEMBL
  RHO UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A2R9AHH0 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9AHI6 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9AHJ1 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9AHJ2 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9AMA2_PANPA UniProtKB/TrEMBL