CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: benzatropine
Accession: CHEBI:3048
browse the term
Definition: Tropane in which a hydrogen at position 3 is substituted by a diphenylmethoxy group (endo-isomer). An acetylcholine receptor antagonist, it is used (particularly as its methanesulphonate salt) in the treatment of Parkinson's disease, and to reduce parkinsonism and akathisia side effects of antipsychotic treatments.
Synonyms: exact_synonym: (3-endo)-3-(diphenylmethoxy)-8-methyl-8-azabicyclo[3.2.1]octane
related_synonym: 3alpha-(diphenylmethoxy)-1alphaH,5alphaH-tropane; 3alpha-(diphenylmethoxy)tropane; 3alpha-benzhydryloxy-8-methyl-8-azabicyclo[3.2.1]octane; 3endo-benzhydryloxytropane; Benztropine; Formula=C21H25NO; InChI=1S/C21H25NO/c1-22-18-12-13-19(22)15-20(14-18)23-21(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18-21H,12-15H2,1H3/t18-,19+,20+; InChIKey=GIJXKZJWITVLHI-PMOLBWCYSA-N; SMILES=[H][C@]1(C[C@]2([H])CC[C@]([H])(C1)N2C)OC(c1ccccc1)c1ccccc1; benzatropina; benzatropinum; benzhydryl 8-methyl-8-azabicyclo[3.2.1]oct-3-yl ether; tropine benzohydryl ether
alt_id: CHEBI:661238
xref: Beilstein:90688; CAS:86-13-5; DrugBank:DB00245; Drug_Central:333; KEGG:C06846; KEGG:D07511
xref_mesh: MESH:D001590
xref: Patent:US2595405; Wikipedia:Benzatropine
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Abcb4
ATP binding cassette subfamily B member 4
decreases activity
ISO
Benztropine results in decreased activity of ABCB4 protein
CTD
PMID:28437613
NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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Acot2
acyl-CoA thioesterase 2
increases expression
ISO
Benztropine results in increased expression of ACOT2 protein
CTD
PMID:34122009
NCBI chr 6:103,611,738...103,619,404
Ensembl chr 6:103,611,544...103,619,245
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Actbl2
actin, beta-like 2
increases expression
ISO
Benztropine results in increased expression of ACTBL2 protein
CTD
PMID:34122009
NCBI chr 2:42,858,020...42,860,767
Ensembl chr 2:42,858,020...42,860,767
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Actr1a
actin related protein 1A
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of ACTR1A protein
CTD
PMID:34122009
NCBI chr 1:245,237,821...245,256,618
Ensembl chr 1:245,237,826...245,256,495
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Actr3
actin related protein 3
decreases expression
ISO
Benztropine results in decreased expression of ACTR3 protein
CTD
PMID:34122009
NCBI chr13:36,800,739...36,843,837
Ensembl chr13:36,800,093...36,844,124
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Adsl
adenylosuccinate lyase
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of ADSL protein
CTD
PMID:34122009
NCBI chr 7:112,479,256...112,503,439
Ensembl chr 7:112,479,271...112,503,760
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Agps
alkylglycerone phosphate synthase
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of AGPS protein
CTD
PMID:34122009
NCBI chr 3:60,747,323...60,845,831
Ensembl chr 3:60,747,323...60,845,830
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Ak1
adenylate kinase 1
decreases expression
ISO
Benztropine results in decreased expression of AK1 protein
CTD
PMID:34122009
NCBI chr 3:15,912,431...15,923,045
Ensembl chr 3:15,912,485...15,923,041
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Anxa1
annexin A1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of ANXA1 protein
CTD
PMID:34122009
NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
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Anxa5
annexin A5
decreases expression
ISO
Benztropine results in decreased expression of ANXA5 protein
CTD
PMID:34122009
NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369
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Anxa6
annexin A6
decreases expression
ISO
Benztropine results in decreased expression of ANXA6 protein
CTD
PMID:34122009
NCBI chr10:39,101,395...39,156,483
Ensembl chr10:39,097,109...39,156,433
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Anxa7
annexin A7
increases expression
ISO
Benztropine results in increased expression of ANXA7 protein
CTD
PMID:34122009
NCBI chr15:3,821,798...3,849,659
Ensembl chr15:3,821,845...3,849,385
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Armt1
acidic residue methyltransferase 1
increases expression
ISO
Benztropine results in increased expression of ARMT1 protein
CTD
PMID:34122009
NCBI chr 1:40,894,558...40,918,302
Ensembl chr 1:40,894,550...40,918,302
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Asns
asparagine synthetase (glutamine-hydrolyzing)
decreases expression
ISO
Benztropine results in decreased expression of ASNS protein
CTD
PMID:34122009
NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
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Asph
aspartate-beta-hydroxylase
increases expression
ISO
Benztropine results in increased expression of ASPH protein
CTD
PMID:34122009
NCBI chr 5:22,601,581...22,814,107
Ensembl chr 5:22,603,486...22,813,876
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Atp2a3
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
increases expression
ISO
Benztropine results in increased expression of ATP2A3 protein
CTD
PMID:34122009
NCBI chr10:57,581,742...57,612,758
Ensembl chr10:57,582,128...57,612,748
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Atp5f1c
ATP synthase F1 subunit gamma
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of ATP5F1C protein
CTD
PMID:34122009
NCBI chr17:68,423,927...68,446,169
Ensembl chr17:68,423,909...68,608,367
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Atp6v1b2
ATPase H+ transporting V1 subunit B2
decreases expression
ISO
Benztropine results in decreased expression of ATP6V1B2 protein
CTD
PMID:34122009
NCBI chr16:20,617,515...20,641,651
Ensembl chr16:20,617,518...20,641,745
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Atxn10
ataxin 10
increases expression
ISO
Benztropine results in increased expression of ATXN10 protein
CTD
PMID:34122009
NCBI chr 7:116,441,768...116,565,093
Ensembl chr 7:116,441,613...116,565,087
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Baz1b
bromodomain adjacent to zinc finger domain, 1B
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of BAZ1B protein
CTD
PMID:34122009
NCBI chr12:21,431,985...21,489,956
Ensembl chr12:21,431,985...21,490,426
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Bcar1
BCAR1 scaffold protein, Cas family member
decreases expression
ISO
Benztropine results in decreased expression of BCAR1 protein
CTD
PMID:34122009
NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907
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Bltp1
bridge-like lipid transfer protein family member 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of BLTP1 protein
CTD
PMID:34122009
NCBI chr 2:119,708,114...119,924,697
Ensembl chr 2:119,708,209...119,924,695
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Bmp6
bone morphogenetic protein 6
increases expression
ISO
Benztropine results in increased expression of BMP6 mRNA
CTD
PMID:32816093
NCBI chr17:26,318,121...26,469,691
Ensembl chr17:26,318,569...26,470,365
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Brd2
bromodomain containing 2
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of BRD2 protein
CTD
PMID:34122009
NCBI chr20:4,727,078...4,735,389
Ensembl chr20:4,728,151...4,735,388
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Bsg
basigin
decreases expression
ISO
Benztropine results in decreased expression of BSG protein
CTD
PMID:34122009
NCBI chr 7:9,993,170...10,000,387
Ensembl chr 7:9,993,170...10,000,387
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Cald1
caldesmon 1
decreases expression multiple interactions
ISO
Benztropine results in decreased expression of CALD1 protein [Cuprizone co-treated with Benztropine] results in decreased expression of CALD1 protein
CTD
PMID:34122009
NCBI chr 4:63,265,781...63,446,938
Ensembl chr 4:63,265,942...63,446,932
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Calu
calumenin
decreases expression
ISO
Benztropine results in decreased expression of CALU protein
CTD
PMID:34122009
NCBI chr 4:57,949,086...57,976,589
Ensembl chr 4:57,948,997...57,976,593
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Camk2d
calcium/calmodulin-dependent protein kinase II delta
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of CAMK2D protein
CTD
PMID:34122009
NCBI chr 2:215,023,785...215,287,351
Ensembl chr 2:215,024,004...215,286,178
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Caprin1
cell cycle associated protein 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of CAPRIN1 protein
CTD
PMID:34122009
NCBI chr 3:90,152,305...90,230,447
Ensembl chr 3:90,153,620...90,230,502
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Casp8ap2
caspase 8 associated protein 2
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of CASP8AP2 protein
CTD
PMID:34122009
NCBI chr 5:47,014,501...47,052,276
Ensembl chr 5:47,014,667...47,052,275
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Cbx5
chromobox 5
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of CBX5 protein
CTD
PMID:34122009
NCBI chr 7:134,333,165...134,376,102
Ensembl chr 7:134,331,335...134,375,022
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Ccar1
cell division cycle and apoptosis regulator 1
increases expression
ISO
Benztropine results in increased expression of CCAR1 protein
CTD
PMID:34122009
NCBI chr20:30,685,916...30,728,531
Ensembl chr20:30,685,916...30,728,526
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Ccdc121
coiled-coil domain containing 121
increases expression
ISO
Benztropine results in increased expression of CCDC121 protein
CTD
PMID:34122009
NCBI chr 6:24,970,845...24,973,451
Ensembl chr 6:24,970,833...24,973,478
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Cct6a
chaperonin containing TCP1 subunit 6A
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of CCT6A protein
CTD
PMID:34122009
NCBI chr12:26,872,736...26,883,125
Ensembl chr12:26,872,574...26,883,337
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Cct7
chaperonin containing TCP1 subunit 7
decreases expression
ISO
Benztropine results in decreased expression of CCT7 protein
CTD
PMID:34122009
NCBI chr 4:117,989,232...118,006,478
Ensembl chr 4:117,989,232...118,006,580
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Cct8
chaperonin containing TCP1 subunit 8
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of CCT8 protein
CTD
PMID:34122009
NCBI chr11:26,710,370...26,722,079
Ensembl chr11:26,710,370...26,722,079
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Cd276
Cd276 molecule
decreases expression
ISO
Benztropine results in decreased expression of CD276 protein
CTD
PMID:34122009
NCBI chr 8:58,937,751...58,968,082
Ensembl chr 8:58,937,751...58,968,380
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Cenpv
centromere protein V
increases expression
ISO
Benztropine results in increased expression of CENPV protein
CTD
PMID:34122009
NCBI chr10:47,214,479...47,228,552
Ensembl chr10:47,214,490...47,228,761
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Chd4
chromodomain helicase DNA binding protein 4
decreases expression
ISO
Benztropine results in decreased expression of CHD4 protein
CTD
PMID:34122009
NCBI chr 4:157,898,503...157,931,632
Ensembl chr 4:157,899,391...157,931,541
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Ckb
creatine kinase B
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of CKB protein
CTD
PMID:34122009
NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315
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Cnp
2',3'-cyclic nucleotide 3' phosphodiesterase
multiple interactions decreases expression
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of CNP protein Benztropine results in decreased expression of CNP protein
CTD
PMID:34122009
NCBI chr10:85,511,164...85,517,723
Ensembl chr10:85,511,160...85,517,720
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Col14a1
collagen type XIV alpha 1 chain
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of COL14A1 protein
CTD
PMID:34122009
NCBI chr 7:86,722,093...86,937,215
Ensembl chr 7:86,722,094...86,937,214
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Col5a2
collagen type V alpha 2 chain
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of COL5A2 protein
CTD
PMID:34122009
NCBI chr 9:47,448,741...47,598,134
Ensembl chr 9:47,448,736...47,598,154
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Cops4
COP9 signalosome subunit 4
decreases expression
ISO
Benztropine results in decreased expression of COPS4 protein
CTD
PMID:34122009
NCBI chr14:9,078,579...9,108,788
Ensembl chr14:9,078,576...9,108,887
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Coro1b
coronin 1B
decreases expression
ISO
Benztropine results in decreased expression of CORO1B protein
CTD
PMID:34122009
NCBI chr 1:201,442,977...201,448,416
Ensembl chr 1:201,443,014...201,448,416
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Coro7
coronin 7
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of CORO7 protein
CTD
PMID:34122009
NCBI chr10:10,880,299...10,941,001
Ensembl chr10:10,885,196...10,941,001
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Cpne3
copine 3
decreases expression
ISO
Benztropine results in decreased expression of CPNE3 protein
CTD
PMID:34122009
NCBI chr 5:33,014,658...33,063,934
Ensembl chr 5:33,016,307...33,063,934
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Cpsf3
cleavage and polyadenylation specific factor 3
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of CPSF3 protein
CTD
PMID:34122009
NCBI chr 6:40,836,121...40,864,129
Ensembl chr 6:40,836,097...40,864,128
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Crtap
cartilage associated protein
increases expression
ISO
Benztropine results in increased expression of CRTAP protein
CTD
PMID:34122009
NCBI chr 8:114,047,929...114,067,636
Ensembl chr 8:114,047,933...114,067,631
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Cryz
crystallin zeta
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of CRYZ protein
CTD
PMID:34122009
NCBI chr 2:243,552,037...243,580,369
Ensembl chr 2:243,552,119...243,579,758
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Csde1
cold shock domain containing E1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of CSDE1 protein
CTD
PMID:34122009
NCBI chr 2:190,546,015...190,582,787
Ensembl chr 2:190,554,980...190,582,784
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Cstf2
cleavage stimulation factor subunit 2
decreases expression
ISO
Benztropine results in decreased expression of CSTF2 protein
CTD
PMID:34122009
NCBI chr X:97,253,559...97,279,476
Ensembl chr X:97,253,586...97,279,476
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Ctbp1
C-terminal binding protein 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of CTBP1 protein
CTD
PMID:34122009
NCBI chr14:77,455,580...77,482,821
Ensembl chr14:77,455,696...77,482,821
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Cul2
cullin 2
increases expression
ISO
Benztropine results in increased expression of CUL2 protein
CTD
PMID:34122009
NCBI chr17:54,169,093...54,210,197
Ensembl chr17:54,169,086...54,209,968
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Cul4b
cullin 4B
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of CUL4B protein
CTD
PMID:34122009
NCBI chr X:117,287,481...117,326,688
Ensembl chr X:117,287,484...117,326,688
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Dars2
aspartyl-tRNA synthetase 2 (mitochondrial)
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of DARS2 protein
CTD
PMID:34122009
NCBI chr13:73,308,726...73,336,558
Ensembl chr13:73,308,726...73,336,934
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Dazap1
DAZ associated protein 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of DAZAP1 protein
CTD
PMID:34122009
NCBI chr 7:9,423,673...9,448,116
Ensembl chr 7:9,424,178...9,538,818
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Dctn2
dynactin subunit 2
increases expression
ISO
Benztropine results in increased expression of DCTN2 protein
CTD
PMID:34122009
NCBI chr 7:63,092,061...63,107,560
Ensembl chr 7:63,092,057...63,108,543
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Ddx17
DEAD-box helicase 17
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of DDX17 protein
CTD
PMID:34122009
NCBI chr 7:111,091,127...111,109,353
Ensembl chr 7:111,089,445...111,109,193
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Ddx3x
DEAD-box helicase 3, X-linked
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of DDX3X protein
CTD
PMID:34122009
NCBI chr X:9,479,532...9,493,169
Ensembl chr X:9,479,532...9,493,168
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Dgcr6
DiGeorge syndrome critical region gene 6
decreases expression
ISO
Benztropine results in decreased expression of DGCR6 protein
CTD
PMID:34122009
NCBI chr11:82,927,725...82,932,823
Ensembl chr11:82,927,725...82,932,823
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Dhcr24
24-dehydrocholesterol reductase
increases expression
ISO
Benztropine results in increased expression of DHCR24 protein
CTD
PMID:34122009
NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137
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Dhx8
DEAH-box helicase 8
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of DHX8 protein
CTD
PMID:34122009
NCBI chr10:86,667,641...86,704,198
Ensembl chr10:86,667,834...86,705,137
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Dlat
dihydrolipoamide S-acetyltransferase
multiple interactions increases expression
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of DLAT protein Benztropine results in increased expression of DLAT protein
CTD
PMID:34122009
NCBI chr 8:50,979,151...51,004,435
Ensembl chr 8:50,978,051...51,004,479
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Dlg2
discs large MAGUK scaffold protein 2
increases expression
ISO
Benztropine results in increased expression of DLG2 protein
CTD
PMID:34122009
NCBI chr 1:144,451,653...146,503,949
Ensembl chr 1:144,451,472...146,499,475
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Dnajb11
DnaJ heat shock protein family (Hsp40) member B11
increases expression
ISO
Benztropine results in increased expression of DNAJB11 protein
CTD
PMID:34122009
NCBI chr11:78,151,750...78,168,259
Ensembl chr11:78,150,429...78,180,407
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Dpp3
dipeptidylpeptidase 3
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of DPP3 protein
CTD
PMID:34122009
NCBI chr 1:202,204,683...202,228,501
Ensembl chr 1:202,204,693...202,228,541
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Dpysl2
dihydropyrimidinase-like 2
decreases expression
ISO
Benztropine results in decreased expression of DPYSL2 protein
CTD
PMID:34122009
NCBI chr15:41,005,551...41,111,724
Ensembl chr15:41,005,551...41,111,829
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Dpysl3
dihydropyrimidinase-like 3
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of DPYSL3 protein
CTD
PMID:34122009
NCBI chr18:35,374,427...35,480,228
Ensembl chr18:35,377,181...35,480,157
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Dync1li1
dynein cytoplasmic 1 light intermediate chain 1
decreases expression
ISO
Benztropine results in decreased expression of DYNC1LI1 protein
CTD
PMID:34122009
NCBI chr 8:114,376,649...114,410,297
Ensembl chr 8:114,376,662...114,410,934
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Ebna1bp2
EBNA1 binding protein 2
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of EBNA1BP2 protein
CTD
PMID:34122009
NCBI chr 5:132,148,164...132,152,730
Ensembl chr 5:132,148,143...132,153,267
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Eef1g
eukaryotic translation elongation factor 1 gamma
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of EEF1G protein
CTD
PMID:34122009
NCBI chr 1:205,860,713...205,871,319
Ensembl chr 1:205,860,698...205,872,382
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Eif2s3
eukaryotic translation initiation factor 2 subunit gamma
increases expression
ISO
Benztropine results in increased expression of EIF2S3 protein
CTD
PMID:34122009
NCBI chr X:58,916,513...58,939,923
Ensembl chr X:58,917,490...58,940,686
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Eif3b
eukaryotic translation initiation factor 3, subunit B
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of EIF3B protein
CTD
PMID:34122009
NCBI chr12:14,196,403...14,220,865
Ensembl chr12:14,196,403...14,220,886
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Eif3c
eukaryotic translation initiation factor 3, subunit C
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of EIF3C protein
CTD
PMID:34122009
NCBI chr 1:181,134,604...181,152,489
Ensembl chr 1:181,134,604...181,152,493
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Eif3h
eukaryotic translation initiation factor 3, subunit H
decreases expression
ISO
Benztropine results in decreased expression of EIF3H protein
CTD
PMID:34122009
NCBI chr 7:83,091,037...83,174,451
Ensembl chr 7:83,091,039...83,174,451
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Eif3l
eukaryotic translation initiation factor 3, subunit L
increases expression multiple interactions
ISO
Benztropine results in increased expression of EIF3L protein [Cuprizone co-treated with Benztropine] results in decreased expression of EIF3L protein
CTD
PMID:34122009
NCBI chr 7:110,652,565...110,663,614
Ensembl chr 7:110,627,107...110,663,614
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Eif5
eukaryotic translation initiation factor 5
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of EIF5 protein
CTD
PMID:34122009
NCBI chr 6:130,589,162...130,597,656
Ensembl chr 6:130,589,143...130,597,656
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Eif5b
eukaryotic translation initiation factor 5B
multiple interactions increases expression
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of EIF5B protein Benztropine results in increased expression of EIF5B protein
CTD
PMID:34122009
NCBI chr 9:40,222,769...40,277,482
Ensembl chr 9:40,222,898...40,277,482
G
Eif6
eukaryotic translation initiation factor 6
decreases expression
ISO
Benztropine results in decreased expression of EIF6 protein
CTD
PMID:34122009
NCBI chr 3:144,325,038...144,331,396
Ensembl chr 3:144,325,036...144,331,401
G
Eno1
enolase 1
decreases expression
ISO
Benztropine results in decreased expression of ENO1 protein
CTD
PMID:34122009
NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
G
Ephb3
Eph receptor B3
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of EPHB3 protein
CTD
PMID:34122009
NCBI chr11:79,840,668...79,859,345
Ensembl chr11:79,840,668...79,859,370
G
Epn1
Epsin 1
decreases expression
ISO
Benztropine results in decreased expression of EPN1 protein
CTD
PMID:34122009
NCBI chr 1:68,742,491...68,760,570
Ensembl chr 1:68,742,789...68,758,874
G
Eps8
EGFR pathway substrate 8, signaling adaptor
decreases expression
ISO
Benztropine results in decreased expression of EPS8 protein
CTD
PMID:34122009
NCBI chr 4:170,388,378...170,486,873
Ensembl chr 4:170,388,378...170,486,873
G
Erh
ERH, mRNA splicing and mitosis factor
increases expression
ISO
Benztropine results in increased expression of ERH protein
CTD
PMID:34122009
NCBI chr 6:100,280,933...100,291,200
Ensembl chr 6:100,280,930...100,291,210
G
Erlin2
ER lipid raft associated 2
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of ERLIN2 protein
CTD
PMID:34122009
NCBI chr16:65,017,654...65,034,184
Ensembl chr16:65,018,532...65,033,671
G
Ewsr1
EWS RNA-binding protein 1
decreases expression
ISO
Benztropine results in decreased expression of EWSR1 protein
CTD
PMID:34122009
NCBI chr14:79,965,365...79,994,108
Ensembl chr14:79,965,368...79,994,544
G
Exosc9
exosome component 9
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of EXOSC9 protein
CTD
PMID:34122009
NCBI chr 2:119,416,028...119,426,981
Ensembl chr 2:119,388,715...119,427,051
G
Ezr
ezrin
decreases expression
ISO
Benztropine results in decreased expression of EZR protein
CTD
PMID:34122009
NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505
G
Fabp3
fatty acid binding protein 3
increases expression
ISO
Benztropine results in increased expression of FABP3 protein
CTD
PMID:34122009
NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718
G
Fdps
farnesyl diphosphate synthase
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of FDPS protein
CTD
PMID:34122009
NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776
G
Flot2
flotillin 2
increases expression
ISO
Benztropine results in increased expression of FLOT2 protein
CTD
PMID:34122009
NCBI chr10:62,926,047...62,947,759
Ensembl chr10:62,920,665...62,947,756
G
Flt1
Fms related receptor tyrosine kinase 1
decreases expression
ISO
Benztropine results in decreased expression of FLT1 protein
CTD
PMID:34122009
NCBI chr12:7,296,899...7,468,626
Ensembl chr12:7,297,292...7,468,626
G
Fyco1
FYVE and coiled-coil domain autophagy adaptor 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of FYCO1 protein
CTD
PMID:34122009
NCBI chr 8:123,412,105...123,479,315
Ensembl chr 8:123,412,112...123,479,021
G
G3bp2
G3BP stress granule assembly factor 2
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of G3BP2 protein
CTD
PMID:34122009
NCBI chr14:15,932,403...16,020,555
Ensembl chr14:15,987,417...16,020,548
G
G6pd
glucose-6-phosphate dehydrogenase
decreases expression
ISO
Benztropine results in decreased expression of G6PD protein
CTD
PMID:34122009
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
G
Galnt2
polypeptide N-acetylgalactosaminyltransferase 2
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of GALNT2 protein
CTD
PMID:34122009
NCBI chr19:52,213,226...52,324,816
Ensembl chr19:52,213,351...52,324,813
G
Gart
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of GART protein
CTD
PMID:34122009
NCBI chr11:30,864,896...30,891,125
Ensembl chr11:30,865,889...30,891,125
G
Gatad2b
GATA zinc finger domain containing 2B
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of GATAD2B protein
CTD
PMID:34122009
NCBI chr 2:175,748,594...175,829,837
Ensembl chr 2:175,749,433...175,825,542
G
Gda
guanine deaminase
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of GDA protein
CTD
PMID:34122009
NCBI chr 1:218,903,045...218,982,360
Ensembl chr 1:218,906,815...218,982,416
G
Gfpt1
glutamine fructose-6-phosphate transaminase 1
decreases expression
ISO
Benztropine results in decreased expression of GFPT1 protein
CTD
PMID:34122009
NCBI chr 4:119,496,691...119,546,472
Ensembl chr 4:119,496,714...119,546,471
G
Ggct
gamma-glutamyl cyclotransferase
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of GGCT protein
CTD
PMID:34122009
NCBI chr 4:84,122,921...84,129,327
Ensembl chr 4:84,123,118...84,129,277
G
Glrx3
glutaredoxin 3
increases expression
ISO
Benztropine results in increased expression of GLRX3 protein
CTD
PMID:34122009
NCBI chr 1:192,241,707...192,272,012
Ensembl chr 1:192,241,701...192,272,010
G
Gls
glutaminase
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of GLS protein
CTD
PMID:34122009
NCBI chr 9:49,344,616...49,416,900
Ensembl chr 9:49,344,781...49,416,900
G
Gna12
G protein subunit alpha 12
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of GNA12 protein
CTD
PMID:34122009
NCBI chr12:13,805,580...13,886,255
Ensembl chr12:13,805,698...13,886,255
G
Golga4
golgin A4
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of GOLGA4 protein
CTD
PMID:34122009
NCBI chr 8:118,208,200...118,285,003
G
Golgb1
golgin B1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of GOLGB1 protein
CTD
PMID:34122009
NCBI chr11:63,843,179...63,900,665
Ensembl chr11:63,843,986...63,900,770
G
Got2
glutamic-oxaloacetic transaminase 2
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of GOT2 protein
CTD
PMID:34122009
NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994
G
Gpi
glucose-6-phosphate isomerase
increases expression
ISO
Benztropine results in increased expression of GPI protein
CTD
PMID:34122009
NCBI chr 1:86,828,211...86,856,077
Ensembl chr 1:86,828,216...86,856,086
G
Gpkow
G patch domain and KOW motifs
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of GPKOW protein
CTD
PMID:34122009
NCBI chr X:14,791,601...14,806,384
Ensembl chr X:14,791,610...14,806,384
G
Gtf2e1
general transcription factor IIE subunit 1
decreases expression
ISO
Benztropine results in decreased expression of GTF2E1 protein
CTD
PMID:34122009
NCBI chr11:63,182,073...63,215,349
Ensembl chr11:63,182,349...63,213,942
G
Gtf2f1
general transcription factor IIF subunit 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of GTF2F1 protein
CTD
PMID:34122009
NCBI chr 9:1,844,027...1,853,455
Ensembl chr 9:1,843,901...1,853,423
G
Gtpbp4
GTP binding protein 4
increases expression
ISO
Benztropine results in increased expression of GTPBP4 protein
CTD
PMID:34122009
NCBI chr17:61,308,033...61,328,184
Ensembl chr17:61,308,014...61,418,009
G
Gys1
glycogen synthase 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of GYS1 protein
CTD
PMID:34122009
NCBI chr 1:95,915,443...95,935,292
Ensembl chr 1:95,915,443...95,935,292
G
H2ac20
H2A clustered histone 20
increases expression
ISO
Benztropine results in increased expression of H2AC20 protein
CTD
PMID:34122009
NCBI chr 2:183,779,879...183,780,357
G
H2aj
H2A.J histone
increases expression
ISO
Benztropine results in increased expression of H2AJ protein
CTD
PMID:34122009
NCBI chr 4:169,675,718...169,676,202
Ensembl chr 4:169,675,752...169,677,006
G
Hacd3
3-hydroxyacyl-CoA dehydratase 3
increases expression
ISO
Benztropine results in increased expression of HACD3 protein
CTD
PMID:34122009
NCBI chr 8:65,501,240...65,538,507
Ensembl chr 8:65,501,240...65,538,507
G
Hadhb
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
increases expression
ISO
Benztropine results in increased expression of HADHB protein
CTD
PMID:34122009
NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869
G
Hars1
histidyl-tRNA synthetase 1
increases expression
ISO
Benztropine results in increased expression of HARS1 protein
CTD
PMID:34122009
NCBI chr18:28,381,649...28,398,699
Ensembl chr18:28,381,655...28,398,740
G
Hat1
histone acetyltransferase 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of HAT1 protein
CTD
PMID:34122009
NCBI chr 3:56,217,344...56,265,021
Ensembl chr 3:56,217,342...56,275,517
G
Hcfc1
host cell factor C1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of HCFC1 protein
CTD
PMID:34122009
NCBI chr X:151,687,779...151,712,688
Ensembl chr X:151,687,779...151,712,638
G
Hmcn2
hemicentin 2
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of HMCN2 protein
CTD
PMID:34122009
NCBI chr 3:14,588,353...14,738,320
Ensembl chr 3:14,588,662...14,738,025
G
Hnrnpd
heterogeneous nuclear ribonucleoprotein D
decreases expression
ISO
Benztropine results in decreased expression of HNRNPD protein
CTD
PMID:34122009
NCBI chr14:9,615,375...9,638,975
Ensembl chr14:9,615,479...9,633,786
G
Hnrnpk
heterogeneous nuclear ribonucleoprotein K
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of HNRNPK protein
CTD
PMID:34122009
NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997
G
Hps3
HPS3, biogenesis of lysosomal organelles complex 2 subunit 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of HPS3 protein
CTD
PMID:34122009
NCBI chr 2:102,484,574...102,527,580
Ensembl chr 2:102,484,574...102,526,047
G
Hsd17b12
hydroxysteroid (17-beta) dehydrogenase 12
increases expression
ISO
Benztropine results in increased expression of HSD17B12 protein
CTD
PMID:34122009
NCBI chr 3:79,990,048...80,113,556
Ensembl chr 3:79,990,056...80,113,617
G
Hsd17b4
hydroxysteroid (17-beta) dehydrogenase 4
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of HSD17B4 protein
CTD
PMID:34122009
NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952
G
Hsp90b1
heat shock protein 90 beta family member 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of HSP90B1 protein
CTD
PMID:34122009
NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788
G
Idi1
isopentenyl-diphosphate delta isomerase 1
decreases expression
ISO
Benztropine results in decreased expression of IDI1 protein
CTD
PMID:34122009
NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357
G
Il1a
interleukin 1 alpha
decreases expression
ISO
Benztropine results in decreased expression of IL1A mRNA
CTD
PMID:32816093
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
G
Il1b
interleukin 1 beta
decreases expression
ISO
Benztropine results in decreased expression of IL1B mRNA
CTD
PMID:32816093
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il24
interleukin 24
increases expression
ISO
Benztropine results in increased expression of IL24 mRNA
CTD
PMID:32816093
NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
G
Jam3
junctional adhesion molecule 3
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of JAM3 protein
CTD
PMID:34122009
NCBI chr 8:25,508,461...25,569,306
Ensembl chr 8:25,507,057...25,569,355
G
Jpt2
Jupiter microtubule associated homolog 2
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of JPT2 protein
CTD
PMID:34122009
NCBI chr10:13,963,135...13,983,212
Ensembl chr10:13,963,137...13,983,170
G
Kars1
lysyl-tRNA synthetase 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of KARS1 protein
CTD
PMID:34122009
NCBI chr19:39,957,846...39,976,837
Ensembl chr19:39,957,846...39,977,632
G
Kcnh2
potassium voltage-gated channel subfamily H member 2
decreases activity
ISO
Benztropine results in decreased activity of KCNH2 protein
CTD
PMID:28551711
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
G
Kctd12
potassium channel tetramerization domain containing 12
decreases expression
ISO
Benztropine results in decreased expression of KCTD12 protein
CTD
PMID:34122009
NCBI chr15:79,800,078...79,806,017
Ensembl chr15:79,801,191...79,806,282
G
Khdrbs1
KH RNA binding domain containing, signal transduction associated 1
decreases expression
ISO
Benztropine results in decreased expression of KHDRBS1 protein
CTD
PMID:34122009
NCBI chr 5:142,051,844...142,089,175
Ensembl chr 5:142,063,570...142,089,180
G
Kif5c
kinesin family member 5C
decreases expression
ISO
Benztropine results in decreased expression of KIF5C protein
CTD
PMID:34122009
NCBI chr 3:34,032,082...34,185,597
Ensembl chr 3:34,032,105...34,182,413
G
Klhdc2
kelch domain containing 2
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of KLHDC2 protein
CTD
PMID:34122009
NCBI chr 6:87,777,183...87,791,609
Ensembl chr 6:87,777,183...87,804,187
G
Klhl41
kelch-like family member 41
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of KLHL41 protein
CTD
PMID:34122009
NCBI chr 3:54,434,291...54,447,415
Ensembl chr 3:54,434,234...54,449,222
G
Kpna4
karyopherin subunit alpha 4
increases expression
ISO
Benztropine results in increased expression of KPNA4 protein
CTD
PMID:34122009
NCBI chr 2:153,319,380...153,381,085
Ensembl chr 2:153,324,273...153,381,081
G
Ktn1
kinectin 1
multiple interactions decreases expression
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of KTN1 protein Benztropine results in decreased expression of KTN1 protein
CTD
PMID:34122009
NCBI chr15:20,913,665...21,002,588
Ensembl chr15:20,914,642...21,002,578
G
Lactb2
lactamase, beta 2
increases expression
ISO
Benztropine results in increased expression of LACTB2 protein
CTD
PMID:34122009
NCBI chr 5:5,569,080...5,591,843
Ensembl chr 5:5,569,067...5,596,429
G
Lamb1
laminin subunit beta 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of LAMB1 protein
CTD
PMID:34122009
NCBI chr 6:47,835,492...47,902,585
Ensembl chr 6:47,835,525...47,902,585
G
Lamc1
laminin subunit gamma 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of LAMC1 protein
CTD
PMID:34122009
NCBI chr13:65,374,372...65,501,492
Ensembl chr13:65,374,372...65,501,492
G
Lima1
LIM domain and actin binding 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of LIMA1 protein
CTD
PMID:34122009
NCBI chr 7:130,901,717...131,001,512
Ensembl chr 7:130,901,717...131,001,473
G
Lipa
lipase A, lysosomal acid type
increases expression
ISO
Benztropine results in increased expression of LIPA protein
CTD
PMID:34122009
NCBI chr 1:232,024,351...232,057,735
Ensembl chr 1:232,024,356...232,057,633
G
Lmod2
leiomodin 2
increases expression
ISO
Benztropine results in increased expression of LMOD2 protein
CTD
PMID:34122009
NCBI chr 4:53,067,428...53,075,124
Ensembl chr 4:53,067,428...53,075,120
G
Lss
lanosterol synthase
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of LSS protein
CTD
PMID:34122009
NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762
G
Lta4h
leukotriene A4 hydrolase
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of LTA4H protein
CTD
PMID:34122009
NCBI chr 7:27,969,796...28,001,600
Ensembl chr 7:27,969,789...28,001,600
G
Luc7l
LUC7-like
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of LUC7L protein
CTD
PMID:34122009
NCBI chr10:15,273,340...15,307,131
Ensembl chr10:15,273,348...15,303,112
G
Magea9
MAGE family member A9
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of MAGEA9 protein
CTD
PMID:34122009
NCBI chr X:142,619,282...142,624,654
Ensembl chr X:142,619,395...142,624,653
G
Maged2
MAGE family member D2
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of MAGED2 protein
CTD
PMID:34122009
NCBI chr X:19,733,593...19,741,769
Ensembl chr X:19,733,597...19,740,477
G
Map1s
microtubule-associated protein 1S
increases expression
ISO
Benztropine results in increased expression of MAP1S protein
CTD
PMID:34122009
NCBI chr16:18,516,759...18,527,777
Ensembl chr16:18,517,574...18,527,988
G
Map4
microtubule-associated protein 4
decreases expression
ISO
Benztropine results in decreased expression of MAP4 protein
CTD
PMID:34122009
NCBI chr 8:109,925,233...110,064,370
Ensembl chr 8:109,925,575...110,064,362
G
Mapre1
microtubule-associated protein, RP/EB family, member 1
decreases expression
ISO
Benztropine results in decreased expression of MAPRE1 protein
CTD
PMID:34122009
NCBI chr 3:142,218,846...142,246,990
Ensembl chr 3:142,212,955...142,246,983
G
Marcksl1
MARCKS-like 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of MARCKSL1 protein
CTD
PMID:34122009
NCBI chr 5:141,851,491...141,853,814
Ensembl chr 5:141,850,110...141,853,817
G
Mat2b
methionine adenosyltransferase 2 non-catalytic beta subunit
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of MAT2B protein
CTD
PMID:34122009
NCBI chr10:25,106,928...25,122,982
Ensembl chr10:25,106,930...25,122,777
G
Mboat7
membrane bound O-acyltransferase domain containing 7
decreases expression
ISO
Benztropine results in decreased expression of MBOAT7 protein
CTD
PMID:34122009
NCBI chr 1:65,525,206...65,539,538
Ensembl chr 1:65,525,213...65,539,538
G
Mdh1
malate dehydrogenase 1
decreases expression
ISO
Benztropine results in decreased expression of MDH1 protein
CTD
PMID:34122009
NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925
G
Met
MET proto-oncogene, receptor tyrosine kinase
increases expression
ISO
Benztropine results in increased expression of MET mRNA
CTD
PMID:32816093
NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
G
Metap2
methionyl aminopeptidase 2
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of METAP2 protein
CTD
PMID:34122009
NCBI chr 7:28,412,429...28,440,458
Ensembl chr 7:28,411,608...28,440,434
G
Mif
macrophage migration inhibitory factor
increases expression
ISO
Benztropine results in increased expression of MIF protein
CTD
PMID:34122009
NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504
G
Mtdh
metadherin
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of MTDH protein
CTD
PMID:34122009
NCBI chr 7:65,306,464...65,365,647
Ensembl chr 7:65,306,400...65,364,413
G
Mthfd1l
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of MTHFD1L protein
CTD
PMID:34122009
NCBI chr 1:40,443,926...40,632,911
Ensembl chr 1:40,444,008...40,632,905
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Myh3
myosin heavy chain 3
increases expression
ISO
Benztropine results in increased expression of MYH3 protein
CTD
PMID:34122009
NCBI chr10:51,770,177...51,793,994
Ensembl chr10:51,770,177...51,793,992
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Nat10
N-acetyltransferase 10
decreases expression
ISO
Benztropine results in decreased expression of NAT10 protein
CTD
PMID:34122009
NCBI chr 3:90,111,643...90,149,891
Ensembl chr 3:90,111,645...90,149,927
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Ncbp1
nuclear cap binding protein subunit 1
decreases expression
ISO
Benztropine results in decreased expression of NCBP1 protein
CTD
PMID:34122009
NCBI chr 5:60,416,023...60,449,004
Ensembl chr 5:60,415,982...60,449,089
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Nectin2
nectin cell adhesion molecule 2
decreases expression
ISO
Benztropine results in decreased expression of NECTIN2 protein
CTD
PMID:34122009
NCBI chr 1:79,372,123...79,407,379
Ensembl chr 1:79,372,119...79,407,360
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Nnmt
nicotinamide N-methyltransferase
increases expression
ISO
Benztropine results in increased expression of NNMT protein
CTD
PMID:34122009
NCBI chr 8:48,928,663...48,947,734
Ensembl chr 8:48,933,598...48,946,655
G
Noc2l
NOC2-like nucleolar associated transcriptional repressor
increases expression
ISO
Benztropine results in increased expression of NOC2L protein
CTD
PMID:34122009
NCBI chr 5:166,820,150...166,831,949
Ensembl chr 5:166,820,161...166,831,949
G
Nsf
N-ethylmaleimide sensitive factor, vesicle fusing ATPase
decreases expression
ISO
Benztropine results in decreased expression of NSF protein
CTD
PMID:34122009
NCBI chr10:88,727,912...88,857,375
Ensembl chr10:88,727,912...88,857,386
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Nsfl1c
NSFL1 cofactor
decreases expression
ISO
Benztropine results in decreased expression of NSFL1C protein
CTD
PMID:34122009
NCBI chr 3:139,978,306...140,002,876
Ensembl chr 3:139,978,301...140,002,870
G
Numa1
nuclear mitotic apparatus protein 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of NUMA1 protein
CTD
PMID:34122009
NCBI chr 1:156,297,907...156,372,855
Ensembl chr 1:156,326,259...156,372,855
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Nup153
nucleoporin 153
increases expression
ISO
Benztropine results in increased expression of NUP153 protein
CTD
PMID:34122009
NCBI chr17:17,972,217...18,024,876
Ensembl chr17:17,972,217...18,024,876
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Nup50
nucleoporin 50
increases expression
ISO
Benztropine results in increased expression of NUP50 protein
CTD
PMID:34122009
NCBI chr 7:116,047,960...116,065,231
Ensembl chr 7:116,048,021...116,066,905
G
Nup54
nucleoporin 54
decreases expression
ISO
Benztropine results in decreased expression of NUP54 protein
CTD
PMID:34122009
NCBI chr14:15,617,630...15,636,029
Ensembl chr14:15,617,679...15,636,028
G
Nup93
nucleoporin 93
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of NUP93 protein
CTD
PMID:34122009
NCBI chr19:10,684,214...10,788,009
Ensembl chr19:10,682,075...10,788,026
G
Nxf1
nuclear RNA export factor 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of NXF1 protein
CTD
PMID:34122009
NCBI chr 1:205,655,442...205,668,637
Ensembl chr 1:205,655,375...205,668,636
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Oat
ornithine aminotransferase
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of OAT protein
CTD
PMID:34122009
NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682
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Ogdh
oxoglutarate dehydrogenase
decreases expression
ISO
Benztropine results in decreased expression of OGDH protein
CTD
PMID:34122009
NCBI chr14:81,150,021...81,217,479
Ensembl chr14:81,150,091...81,217,479
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Ola1
Obg-like ATPase 1
increases expression
ISO
Benztropine results in increased expression of OLA1 protein
CTD
PMID:34122009
NCBI chr 3:57,966,896...58,085,955
Ensembl chr 3:57,966,896...58,084,480
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P4hb
prolyl 4-hydroxylase subunit beta
decreases expression
ISO
Benztropine results in decreased expression of P4HB protein
CTD
PMID:34122009
NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500
G
Pa2g4
proliferation-associated 2G4
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of PA2G4 protein
CTD
PMID:34122009
NCBI chr 7:984,795...992,264
Ensembl chr 7:983,971...992,331
G
Pafah1b1
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of PAFAH1B1 protein
CTD
PMID:34122009
NCBI chr10:59,533,042...59,591,808
Ensembl chr10:59,534,117...59,591,808
G
Pag1
phosphoprotein membrane anchor with glycosphingolipid microdomains 1
decreases expression
ISO
Benztropine results in decreased expression of PAG1 protein
CTD
PMID:34122009
NCBI chr 2:91,935,378...92,076,937
Ensembl chr 2:92,057,216...92,069,849
G
Parp1
poly (ADP-ribose) polymerase 1
multiple interactions decreases expression
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of PARP1 protein Benztropine results in decreased expression of PARP1 protein
CTD
PMID:34122009
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Pc
pyruvate carboxylase
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of PC protein
CTD
PMID:34122009
NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380
G
Pcbp1
poly(rC) binding protein 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of PCBP1 protein
CTD
PMID:34122009
NCBI chr 4:118,972,698...118,974,705
Ensembl chr 4:118,972,661...118,976,500
G
Pcbp2
poly(rC) binding protein 2
decreases expression
ISO
Benztropine results in decreased expression of PCBP2 protein
CTD
PMID:34122009
NCBI chr 7:133,605,375...133,631,312
Ensembl chr 7:133,605,573...133,629,863
G
Pcdhga2
protocadherin gamma subfamily A, 2
decreases expression
ISO
Benztropine results in decreased expression of PCDHGA2 protein
CTD
PMID:34122009
NCBI chr18:29,493,954...29,667,865
Ensembl chr18:29,493,954...29,667,868
G
Pcmt1
protein-L-isoaspartate (D-aspartate) O-methyltransferase 1
decreases expression
ISO
Benztropine results in decreased expression of PCMT1 protein
CTD
PMID:34122009
NCBI chr 1:2,111,756...2,160,354
Ensembl chr 1:2,111,763...2,159,201
G
Pcnp
PEST proteolytic signal containing nuclear protein
increases expression
ISO
Benztropine results in increased expression of PCNP protein
CTD
PMID:34122009
NCBI chr11:44,592,766...44,607,372
Ensembl chr11:44,592,742...44,607,348
G
Pdcl3
phosducin-like 3
decreases expression
ISO
Benztropine results in decreased expression of PDCL3 protein
CTD
PMID:34122009
NCBI chr 9:41,234,322...41,243,769
Ensembl chr 9:41,234,234...41,243,735
G
Pdia3
protein disulfide isomerase family A, member 3
decreases expression
ISO
Benztropine results in decreased expression of PDIA3 protein
CTD
PMID:34122009
NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236
G
Pdia6
protein disulfide isomerase family A, member 6
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of PDIA6 protein
CTD
PMID:34122009
NCBI chr 6:40,062,980...40,080,223
Ensembl chr 6:40,062,926...40,080,613
G
Pdlim5
PDZ and LIM domain 5
decreases expression
ISO
Benztropine results in decreased expression of PDLIM5 protein
CTD
PMID:34122009
NCBI chr 2:230,952,251...231,120,329
Ensembl chr 2:230,952,248...231,120,275
G
Pebp1
phosphatidylethanolamine binding protein 1
decreases expression
ISO
Benztropine results in decreased expression of PEBP1 protein
CTD
PMID:34122009
NCBI chr12:39,302,864...39,307,064
Ensembl chr12:39,302,840...39,307,862
G
Pfn1
profilin 1
increases expression
ISO
Benztropine results in increased expression of PFN1 protein
CTD
PMID:34122009
NCBI chr10:55,365,263...55,367,968
Ensembl chr10:55,365,262...55,527,631
G
Pgk1
phosphoglycerate kinase 1
decreases expression
ISO
Benztropine results in decreased expression of PGK1 protein
CTD
PMID:34122009
NCBI chr X:71,271,454...71,287,429
Ensembl chr X:71,271,440...71,287,418
G
Pgm3
phosphoglucomutase 3
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of PGM3 protein
CTD
PMID:34122009
NCBI chr 8:87,518,317...87,536,021
Ensembl chr 8:87,517,701...87,536,022
G
Phf14
PHD finger protein 14
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of PHF14 protein
CTD
PMID:34122009
NCBI chr 4:40,009,691...40,195,877
Ensembl chr 4:40,009,264...40,195,885
G
Phgdh
phosphoglycerate dehydrogenase
decreases expression
ISO
Benztropine results in decreased expression of PHGDH protein
CTD
PMID:34122009
NCBI chr 2:185,906,962...185,936,054
Ensembl chr 2:185,906,966...185,935,944
G
Pid1
phosphotyrosine interaction domain containing 1
increases expression
ISO
Benztropine results in increased expression of PID1 mRNA
CTD
PMID:32816093
NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044
G
Pin1
peptidylprolyl cis/trans isomerase, NIMA-interacting 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of PIN1 protein
CTD
PMID:34122009
NCBI chr 8:19,189,408...19,200,785
Ensembl chr 8:19,189,373...19,200,785
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Pmpca
peptidase, mitochondrial processing subunit alpha
increases expression
ISO
Benztropine results in increased expression of PMPCA protein
CTD
PMID:34122009
NCBI chr 3:9,207,731...9,216,846
Ensembl chr 3:9,207,717...9,216,844
G
Pnma1
PNMA family member 1
increases expression
ISO
Benztropine results in increased expression of PNMA1 protein
CTD
PMID:34122009
NCBI chr 6:103,782,244...103,784,029
Ensembl chr 6:103,773,889...103,784,567
G
Pnma8a
PNMA family member 8A
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of PNMA8A protein
CTD
PMID:34122009
NCBI chr 1:77,629,272...77,643,156
Ensembl chr 1:77,639,423...77,642,082
G
Pon3
paraoxonase 3
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of PON3 protein
CTD
PMID:34122009
NCBI chr 4:33,356,983...33,383,681
Ensembl chr 4:33,349,168...33,383,855
G
Ppa1
inorganic pyrophosphatase 1
multiple interactions increases expression
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of PPA1 protein Benztropine results in increased expression of PPA1 protein
CTD
PMID:34122009
NCBI chr20:29,590,733...29,617,711
Ensembl chr20:29,590,707...29,619,215
G
Ppm1f
protein phosphatase, Mg2+/Mn2+ dependent, 1F
decreases expression
ISO
Benztropine results in decreased expression of PPM1F protein
CTD
PMID:34122009
NCBI chr11:84,064,422...84,094,410
Ensembl chr11:84,064,420...84,094,340
G
Ppp1r12a
protein phosphatase 1, regulatory subunit 12A
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of PPP1R12A protein
CTD
PMID:34122009
NCBI chr 7:43,482,808...43,593,689
Ensembl chr 7:43,482,803...43,593,425
G
Ppp1r14b
protein phosphatase 1, regulatory (inhibitor) subunit 14B
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of PPP1R14B protein
CTD
PMID:34122009
NCBI chr 1:204,165,210...204,167,320
Ensembl chr 1:204,163,299...204,167,319
G
Ppp3ca
protein phosphatase 3 catalytic subunit alpha
increases expression
ISO
Benztropine results in increased expression of PPP3CA protein
CTD
PMID:34122009
NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974
G
Prkar2a
protein kinase cAMP-dependent type II regulatory subunit alpha
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of PRKAR2A protein
CTD
PMID:34122009
NCBI chr 8:109,393,189...109,458,832
Ensembl chr 8:109,395,833...109,455,628
G
Prkcsh
PRKCSH beta subunit of glucosidase II
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of PRKCSH protein
CTD
PMID:34122009
NCBI chr 8:20,534,787...20,546,493
Ensembl chr 8:20,534,880...20,546,492
G
Prmt1
protein arginine methyltransferase 1
decreases expression
ISO
Benztropine results in decreased expression of PRMT1 protein
CTD
PMID:34122009
NCBI chr 1:95,458,853...95,468,176
Ensembl chr 1:95,458,850...95,468,345
G
Prpf6
pre-mRNA processing factor 6
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of PRPF6 protein
CTD
PMID:34122009
NCBI chr 3:168,706,952...168,771,191
Ensembl chr 3:168,704,299...168,774,991
G
Psma1
proteasome 20S subunit alpha 1
decreases expression
ISO
Benztropine results in decreased expression of PSMA1 protein
CTD
PMID:34122009
NCBI chr 1:168,442,421...168,453,440
Ensembl chr 1:168,440,936...168,453,472
G
Psmb7
proteasome 20S subunit beta 7
decreases expression
ISO
Benztropine results in decreased expression of PSMB7 protein
CTD
PMID:34122009
NCBI chr 3:22,357,777...22,417,748
Ensembl chr 3:22,354,698...22,417,937
G
Psmc1
proteasome 26S subunit, ATPase 1
decreases expression
ISO
Benztropine results in decreased expression of PSMC1 protein
CTD
PMID:34122009
NCBI chr 6:119,392,833...119,405,233
Ensembl chr 6:119,392,855...119,410,123
G
Psmc3
proteasome 26S subunit, ATPase 3
increases expression
ISO
Benztropine results in increased expression of PSMC3 protein
CTD
PMID:34122009
NCBI chr 3:77,031,825...77,037,207
Ensembl chr 3:77,031,825...77,043,358
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Psmd7
proteasome 26S subunit, non-ATPase 7
increases expression
ISO
Benztropine results in increased expression of PSMD7 protein
CTD
PMID:34122009
NCBI chr19:35,494,317...35,501,605
Ensembl chr19:35,494,316...35,501,588
G
Ptcd3
Pentatricopeptide repeat domain 3
increases expression multiple interactions
ISO
Benztropine results in increased expression of PTCD3 protein [Cuprizone co-treated with Benztropine] results in decreased expression of PTCD3 protein
CTD
PMID:34122009
NCBI chr 4:103,922,440...103,957,445
Ensembl chr 4:103,920,566...103,957,538
G
Ptgs2
prostaglandin-endoperoxide synthase 2
decreases expression
ISO
Benztropine results in decreased expression of PTGS2 mRNA
CTD
PMID:32816093
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
G
Ptk7
protein tyrosine kinase 7
decreases expression
ISO
Benztropine results in decreased expression of PTK7 protein
CTD
PMID:34122009
NCBI chr 9:14,352,155...14,418,473
Ensembl chr 9:14,351,202...14,418,494
G
Puf60
poly-U binding splicing factor 60
decreases expression
ISO
Benztropine results in decreased expression of PUF60 protein
CTD
PMID:34122009
NCBI chr 7:107,782,799...107,793,759
Ensembl chr 7:107,782,770...107,794,531
G
Pwp2
PWP2, small subunit processome component
increases expression
ISO
Benztropine results in increased expression of PWP2 protein
CTD
PMID:34122009
NCBI chr20:10,499,332...10,512,965
Ensembl chr20:10,499,363...10,513,640
G
Pycr1
pyrroline-5-carboxylate reductase 1
increases expression
ISO
Benztropine results in increased expression of PYCR1 protein
CTD
PMID:34122009
NCBI chr10:105,917,732...105,922,658
Ensembl chr10:105,917,680...105,922,549
G
Qdpr
quinoid dihydropteridine reductase
decreases expression
ISO
Benztropine results in decreased expression of QDPR protein
CTD
PMID:34122009
NCBI chr14:65,670,251...65,683,853
Ensembl chr14:65,670,131...65,683,854
G
Rack1
receptor for activated C kinase 1
decreases expression
ISO
Benztropine results in decreased expression of RACK1 protein
CTD
PMID:34122009
NCBI chr10:33,169,415...33,174,896
Ensembl chr10:33,169,169...33,174,975
G
Rbm15
RNA binding motif protein 15
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of RBM15 protein
CTD
PMID:34122009
NCBI chr 2:194,945,974...194,954,498
Ensembl chr 2:194,945,974...194,954,703
G
Ric8a
RIC8 guanine nucleotide exchange factor A
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of RIC8A protein
CTD
PMID:34122009
NCBI chr 1:195,935,162...195,941,469
Ensembl chr 1:195,935,349...195,941,467
G
Rpl10a
ribosomal protein L10A
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of RPL10A protein
CTD
PMID:34122009
NCBI chr20:6,388,800...6,391,358
Ensembl chr20:6,385,823...6,391,357
G
Rpl19
ribosomal protein L19
increases expression
ISO
Benztropine results in increased expression of RPL19 protein
CTD
PMID:34122009
NCBI chr10:83,022,503...83,026,030
Ensembl chr10:83,019,257...83,052,112
G
Rpl24
ribosomal protein L24
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of RPL24 protein
CTD
PMID:34122009
NCBI chr11:44,653,937...44,659,346
Ensembl chr11:44,653,937...44,659,370
G
Rpl30
ribosomal protein L30
increases expression
ISO
Benztropine results in increased expression of RPL30 protein
CTD
PMID:34122009
NCBI chr 7:65,648,266...65,651,401
Ensembl chr 7:65,645,991...65,651,363 Ensembl chr10:65,645,991...65,651,363 Ensembl chr10:65,645,991...65,651,363
G
Rpl7a
ribosomal protein L7A
decreases expression
ISO
Benztropine results in decreased expression of RPL7A protein
CTD
PMID:34122009
NCBI chr 3:10,239,026...10,241,703
Ensembl chr 3:10,239,001...10,241,716
G
Rplp1
ribosomal protein lateral stalk subunit P1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of RPLP1 protein
CTD
PMID:34122009
NCBI chr 8:62,394,008...62,395,341
Ensembl chr 8:62,393,177...62,395,339
G
Rps12
ribosomal protein S12
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of RPS12 protein
CTD
PMID:34122009
NCBI chr 1:21,680,854...21,683,010
Ensembl chr 1:21,680,852...21,683,014
G
Rps18
ribosomal protein S18
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of RPS18 protein
CTD
PMID:34122009
NCBI chr20:4,931,427...4,935,538
Ensembl chr10:101,204,500...101,205,146 Ensembl chr20:101,204,500...101,205,146
G
Rps27
ribosomal protein S27
increases expression
ISO
Benztropine results in increased expression of RPS27 protein
CTD
PMID:34122009
NCBI chr 2:175,665,858...175,666,963
Ensembl chr 2:175,665,853...175,666,964
G
Rps27a
ribosomal protein S27a
increases expression
ISO
Benztropine results in increased expression of RPS27A protein
CTD
PMID:34122009
NCBI chr14:103,285,734...103,288,011
Ensembl chr14:103,285,734...103,288,011 Ensembl chr 5:103,285,734...103,288,011
G
Rps3
ribosomal protein S3
decreases expression
ISO
Benztropine results in decreased expression of RPS3 protein
CTD
PMID:34122009
NCBI chr 1:153,778,363...153,783,663
Ensembl chr 1:153,777,472...153,783,680
G
Ruvbl2
RuvB-like AAA ATPase 2
increases expression
ISO
Benztropine results in increased expression of RUVBL2 protein
CTD
PMID:34122009
NCBI chr 1:95,902,014...95,915,247
Ensembl chr 1:95,901,701...95,915,342
G
Sae1
SUMO1 activating enzyme subunit 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of SAE1 protein
CTD
PMID:34122009
NCBI chr 1:77,030,961...77,086,937
Ensembl chr 1:77,030,965...77,086,986
G
Sars1
seryl-tRNA synthetase 1
decreases expression
ISO
Benztropine results in decreased expression of SARS1 protein
CTD
PMID:34122009
NCBI chr 2:196,065,543...196,081,240
Ensembl chr 2:196,065,430...196,081,277
G
Satb2
SATB homeobox 2
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of SATB2 protein
CTD
PMID:34122009
NCBI chr 9:58,348,027...58,534,256
Ensembl chr 9:58,350,246...58,530,707
G
Sccpdh
saccharopine dehydrogenase (putative)
decreases expression
ISO
Benztropine results in decreased expression of SCCPDH protein
CTD
PMID:34122009
NCBI chr13:91,400,120...91,421,875
Ensembl chr13:91,400,190...91,422,222
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Sdcbp
syndecan binding protein
decreases expression
ISO
Benztropine results in decreased expression of SDCBP protein
CTD
PMID:34122009
NCBI chr 5:19,473,499...19,517,188
Ensembl chr 5:19,489,961...19,527,572
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Sec23a
Sec23 homolog A, COPII coat complex component
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of SEC23A protein
CTD
PMID:34122009
NCBI chr 6:76,658,793...76,706,125
Ensembl chr 6:76,658,427...76,706,035
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Sec61b
SEC61 translocon subunit beta
increases expression
ISO
Benztropine results in increased expression of SEC61B protein
CTD
PMID:34122009
NCBI chr 5:61,773,594...61,781,804
Ensembl chr 5:61,773,594...61,781,804
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Sec63
SEC63 homolog, protein translocation regulator
increases expression
ISO
Benztropine results in increased expression of SEC63 protein
CTD
PMID:34122009
NCBI chr20:46,245,101...46,314,055
Ensembl chr20:46,245,101...46,314,055
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Serbp1
Serpine1 mRNA binding protein 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of SERBP1 protein
CTD
PMID:34122009
NCBI chr 4:96,401,587...96,421,816
Ensembl chr 4:96,401,477...96,421,813
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Serpinb3a
serpin family B member 3A
increases expression
ISO
Benztropine results in increased expression of SERPINB4 protein
CTD
PMID:34122009
NCBI chr13:23,241,303...23,246,328
Ensembl chr13:23,236,972...23,246,985
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Sf1
splicing factor 1
decreases expression
ISO
Benztropine results in decreased expression of SF1 protein
CTD
PMID:34122009
NCBI chr 1:203,670,016...203,683,432
Ensembl chr 1:203,670,018...203,684,330
G
Sf3b3
splicing factor 3b, subunit 3
decreases expression
ISO
Benztropine results in decreased expression of SF3B3 protein
CTD
PMID:34122009
NCBI chr19:38,782,749...38,820,271
Ensembl chr19:38,783,040...38,820,245
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Sgca
sarcoglycan, alpha
decreases expression
ISO
Benztropine results in decreased expression of SGCA protein
CTD
PMID:34122009
NCBI chr10:79,904,698...79,922,808
Ensembl chr10:79,908,738...79,922,813
G
Sh3pxd2b
SH3 and PX domains 2B
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of SH3PXD2B protein
CTD
PMID:34122009
NCBI chr10:16,918,611...17,027,499
Ensembl chr10:16,918,679...17,005,170
G
Shmt1
serine hydroxymethyltransferase 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of SHMT1 protein
CTD
PMID:34122009
NCBI chr10:45,468,698...45,490,833
Ensembl chr10:45,468,700...45,497,820
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Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Benztropine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Slc25a5-ps11
solute carrier family 25 member 5, pseudogene 11
increases expression
ISO
Benztropine results in increased expression of SLC25A6 protein
CTD
PMID:34122009
NCBI chr18:68,571,222...68,572,461
Ensembl chr18:68,571,300...68,572,199
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Slc2a1
solute carrier family 2 member 1
decreases expression
ISO
Benztropine results in decreased expression of SLC2A1 protein
CTD
PMID:34122009
NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
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Slc38a2
solute carrier family 38, member 2
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of SLC38A2 protein
CTD
PMID:34122009
NCBI chr 7:127,851,267...127,863,482
Ensembl chr 7:127,851,267...127,863,436
G
Slc3a2
solute carrier family 3 member 2
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of SLC3A2 protein
CTD
PMID:34122009
NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931
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Slc6a3
solute carrier family 6 member 3
multiple interactions
ISO
Benztropine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]
CTD
PMID:17250655
NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
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Slpi
secretory leukocyte peptidase inhibitor
increases expression
ISO
Benztropine results in increased expression of SLPI mRNA
CTD
PMID:32816093
NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
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Smarcb1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
decreases expression
ISO
Benztropine results in decreased expression of SMARCB1 protein
CTD
PMID:34122009
NCBI chr20:12,741,164...12,763,616
Ensembl chr20:12,741,477...12,763,620
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Smc3
structural maintenance of chromosomes 3
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of SMC3 protein
CTD
PMID:34122009
NCBI chr 1:252,601,422...252,644,522
Ensembl chr 1:252,601,753...252,644,522
G
Smu1
SMU1, DNA replication regulator and spliceosomal factor
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of SMU1 protein
CTD
PMID:34122009
NCBI chr 5:55,856,691...55,875,262
Ensembl chr 5:55,856,246...55,875,300
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Snrnp200
small nuclear ribonucleoprotein U5 subunit 200
multiple interactions increases expression
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of SNRNP200 protein Benztropine results in increased expression of SNRNP200 protein
CTD
PMID:34122009
NCBI chr 3:114,428,854...114,458,194
Ensembl chr 3:114,428,854...114,458,182
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Snrpa
small nuclear ribonucleoprotein polypeptide A
increases expression
ISO
Benztropine results in increased expression of SNRPA protein
CTD
PMID:34122009
NCBI chr 1:82,481,770...82,490,540
Ensembl chr 1:82,481,770...82,490,538
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Snrpd2
small nuclear ribonucleoprotein D2 polypeptide
increases expression
ISO
Benztropine results in increased expression of SNRPD2 protein
CTD
PMID:34122009
NCBI chr 1:78,798,377...78,801,227
Ensembl chr 1:78,798,377...78,803,351
G
Srek1
splicing regulatory glutamic acid and lysine rich protein 1
decreases expression
ISO
Benztropine results in decreased expression of SREK1 protein
CTD
PMID:34122009
NCBI chr 2:34,849,548...34,885,120
Ensembl chr 2:34,852,458...34,884,972
G
Srsf5
serine and arginine rich splicing factor 5
increases expression
ISO
Benztropine results in increased expression of SRSF5 protein
CTD
PMID:34122009
NCBI chr 6:100,605,165...100,610,192
Ensembl chr 6:100,605,456...100,610,177
G
Stat3
signal transducer and activator of transcription 3
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of STAT3 protein
CTD
PMID:34122009
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
G
Stim1
stromal interaction molecule 1
decreases expression
ISO
Benztropine results in decreased expression of STIM1 protein
CTD
PMID:34122009
NCBI chr 1:156,656,246...156,818,777
Ensembl chr 1:156,656,013...156,818,363
G
Stip1
stress-induced phosphoprotein 1
decreases expression
ISO
Benztropine results in decreased expression of STIP1 protein
CTD
PMID:34122009
NCBI chr 1:204,209,433...204,228,452
Ensembl chr 1:204,178,932...204,228,476
G
Strap
serine/threonine kinase receptor associated protein
decreases expression
ISO
Benztropine results in decreased expression of STRAP protein
CTD
PMID:34122009
NCBI chr 4:170,646,042...170,660,291
Ensembl chr 4:170,646,001...170,660,828
G
Stub1
STIP1 homology and U-box containing protein 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of STUB1 protein
CTD
PMID:34122009
NCBI chr10:14,850,765...14,853,046
Ensembl chr10:14,850,765...14,853,046
G
Suclg1
succinate-CoA ligase GDP/ADP-forming subunit alpha
decreases expression
ISO
Benztropine results in decreased expression of SUCLG1 protein
CTD
PMID:34122009
NCBI chr 4:105,308,236...105,337,595
Ensembl chr 4:105,308,039...105,337,600
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Sumo2
small ubiquitin-like modifier 2
decreases expression
ISO
Benztropine results in decreased expression of SUMO2 protein
CTD
PMID:34122009
NCBI chr10:100,771,941...100,784,503
Ensembl chr10:100,686,797...100,784,513
G
Sun1
Sad1 and UNC84 domain containing 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of SUN1 protein
CTD
PMID:34122009
NCBI chr12:15,396,378...15,441,277
Ensembl chr12:15,396,381...15,441,571
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Syncrip
synaptotagmin binding, cytoplasmic RNA interacting protein
decreases expression
ISO
Benztropine results in decreased expression of SYNCRIP protein
CTD
PMID:34122009
NCBI chr 8:89,402,487...89,435,517
Ensembl chr 8:89,402,866...89,435,515
G
Tagln2
transgelin 2
decreases expression
ISO
Benztropine results in decreased expression of TAGLN2 protein
CTD
PMID:34122009
NCBI chr13:84,966,980...84,973,973
Ensembl chr13:84,967,009...84,973,972
G
Tbcb
tubulin folding cofactor B
decreases expression
ISO
Benztropine results in decreased expression of TBCB protein
CTD
PMID:34122009
NCBI chr 1:85,477,639...85,483,488
Ensembl chr 1:85,477,640...85,483,488
G
Tcaf1
TRPM8 channel-associated factor 1
multiple interactions decreases expression
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of TCAF1 protein Benztropine results in decreased expression of TCAF1 protein
CTD
PMID:34122009
NCBI chr 4:71,589,674...71,639,274
Ensembl chr 4:71,591,200...71,613,309
G
Tgoln2
trans-golgi network protein 2
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of TGOLN2 protein
CTD
PMID:34122009
NCBI chr 4:104,663,356...104,671,208
Ensembl chr 4:104,663,353...104,671,164
G
Tln2
talin 2
decreases expression
ISO
Benztropine results in decreased expression of TLN2 protein
CTD
PMID:34122009
NCBI chr 8:67,830,920...68,252,240
Ensembl chr 8:67,834,326...68,252,219
G
Tmpo
thymopoietin
decreases expression
ISO
Benztropine results in decreased expression of TMPO protein
CTD
PMID:34122009
NCBI chr 7:25,642,752...25,667,756
Ensembl chr 7:25,586,725...25,667,727
G
Tnks1bp1
tankyrase 1 binding protein 1
multiple interactions decreases expression
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of TNKS1BP1 protein Benztropine results in decreased expression of TNKS1BP1 protein
CTD
PMID:34122009
NCBI chr 3:70,135,335...70,160,071
Ensembl chr 3:70,137,837...70,160,038
G
Tomm34
translocase of outer mitochondrial membrane 34
decreases expression multiple interactions
ISO
Benztropine results in decreased expression of TOMM34 protein [Cuprizone co-treated with Benztropine] results in increased expression of TOMM34 protein
CTD
PMID:34122009
NCBI chr 3:152,729,345...152,746,295
Ensembl chr 3:152,729,349...152,746,373
G
Top1mt
DNA topoisomerase I mitochondrial
increases expression
ISO
Benztropine results in increased expression of TOP1MT protein
CTD
PMID:34122009
NCBI chr 7:107,338,092...107,368,125
Ensembl chr 7:107,342,527...107,366,049
G
Tpm2
tropomyosin 2
decreases expression
ISO
Benztropine results in decreased expression of TPM2 protein
CTD
PMID:34122009
NCBI chr 5:57,770,919...57,780,278
Ensembl chr 5:57,770,864...57,779,992
G
Tpm3
tropomyosin 3
decreases expression
ISO
Benztropine results in decreased expression of TPM3 protein
CTD
PMID:34122009
NCBI chr 2:175,517,198...175,545,014
Ensembl chr 2:175,517,226...175,545,013
G
Tpr
translocated promoter region, nuclear basket protein
decreases expression
ISO
Benztropine results in decreased expression of TPR protein
CTD
PMID:34122009
NCBI chr13:62,424,312...62,487,502
Ensembl chr13:62,424,312...62,487,496
G
Trim28
tripartite motif-containing 28
decreases expression multiple interactions
ISO
Benztropine results in decreased expression of TRIM28 protein [Cuprizone co-treated with Benztropine] results in increased expression of TRIM28 protein
CTD
PMID:34122009
NCBI chr 1:73,652,441...73,659,388
Ensembl chr 1:73,652,709...73,659,380
G
Tspan3
tetraspanin 3
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of TSPAN3 protein
CTD
PMID:34122009
NCBI chr 8:56,546,067...56,569,815
Ensembl chr 8:56,546,069...56,569,880
G
Ttc21a
tetratricopeptide repeat domain 21A
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of TTC21A protein
CTD
PMID:34122009
NCBI chr 8:119,667,044...119,702,028
Ensembl chr 8:119,666,933...119,702,456
G
Ttyh2
tweety family member 2
increases expression
ISO
Benztropine results in increased expression of TTYH2 protein
CTD
PMID:34122009
NCBI chr10:99,709,063...99,753,449
Ensembl chr10:99,709,007...99,753,444
G
Ttyh3
tweety family member 3
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of TTYH3 protein
CTD
PMID:34122009
NCBI chr12:13,996,831...14,025,457
Ensembl chr12:13,997,045...14,025,459
G
Tubb5
tubulin, beta 5 class I
increases expression
ISO
Benztropine results in increased expression of TUBB protein
CTD
PMID:34122009
NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940
G
Twf2
twinfilin actin-binding protein 2
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of TWF2 protein
CTD
PMID:34122009
NCBI chr 8:106,845,253...106,858,298
Ensembl chr 8:106,845,253...106,858,298
G
Txlna
taxilin alpha
decreases expression
ISO
Benztropine results in decreased expression of TXLNA protein
CTD
PMID:34122009
NCBI chr 5:141,969,337...141,985,054
Ensembl chr 5:141,969,346...141,984,583
G
Tyms
thymidylate synthetase
increases expression
ISO
Benztropine results in increased expression of TYMS protein
CTD
PMID:34122009
NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536
G
U2af2
U2 small nuclear RNA auxiliary factor 2
decreases expression
ISO
Benztropine results in decreased expression of U2AF2 protein
CTD
PMID:34122009
NCBI chr 1:68,760,911...68,779,730
Ensembl chr 1:68,760,924...68,778,492
G
Uba2
ubiquitin-like modifier activating enzyme 2
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of UBA2 protein
CTD
PMID:34122009
NCBI chr 1:86,775,239...86,802,685
Ensembl chr 1:86,775,244...86,802,682
G
Ubap2l
ubiquitin associated protein 2-like
decreases expression
ISO
Benztropine results in decreased expression of UBAP2L protein
CTD
PMID:34122009
NCBI chr 2:175,438,703...175,494,085
Ensembl chr 2:175,438,703...175,493,998
G
Ubc
ubiquitin C
increases expression
ISO
Benztropine results in increased expression of UBC protein
CTD
PMID:34122009
NCBI chr12:31,239,149...31,243,924
Ensembl chr12:31,239,152...31,243,925
G
Ubqln2
ubiquilin 2
decreases expression
ISO
Benztropine results in decreased expression of UBQLN2 protein
CTD
PMID:34122009
NCBI chr X:17,853,086...17,856,505
Ensembl chr X:17,853,114...17,856,505
G
Uchl1
ubiquitin C-terminal hydrolase L1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of UCHL1 protein
CTD
PMID:34122009
NCBI chr14:41,485,031...41,495,590
Ensembl chr14:41,485,031...41,495,590
G
Uchl3
ubiquitin C-terminal hydrolase L3
decreases expression
ISO
Benztropine results in decreased expression of UCHL3 protein
CTD
PMID:34122009
NCBI chr15:78,485,304...78,527,355
Ensembl chr15:78,485,315...78,527,355 Ensembl chr 3:78,485,315...78,527,355
G
Ugdh
UDP-glucose 6-dehydrogenase
decreases expression
ISO
Benztropine results in decreased expression of UGDH protein
CTD
PMID:34122009
NCBI chr14:42,848,704...42,872,351
Ensembl chr14:42,848,854...42,872,354
G
Unc45b
unc-45 myosin chaperone B
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of UNC45B protein
CTD
PMID:34122009
NCBI chr10:67,845,464...67,873,143
Ensembl chr10:67,845,462...67,873,389
G
Uqcrc2
ubiquinol cytochrome c reductase core protein 2
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of UQCRC2 protein
CTD
PMID:34122009
NCBI chr 1:175,167,933...175,198,499
Ensembl chr 1:175,167,894...175,199,453
G
Uso1
USO1 vesicle transport factor
decreases expression
ISO
Benztropine results in decreased expression of USO1 protein
CTD
PMID:34122009
NCBI chr14:15,866,638...15,932,185
Ensembl chr14:15,866,638...15,932,171
G
Usp10
ubiquitin specific peptidase 10
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of USP10 protein
CTD
PMID:34122009
NCBI chr19:47,972,858...48,014,900
Ensembl chr19:47,972,611...48,014,897
G
Usp14
ubiquitin specific peptidase 14
increases expression
ISO
Benztropine results in increased expression of USP14 protein
CTD
PMID:34122009
NCBI chr18:1,018,111...1,057,727
Ensembl chr18:1,019,400...1,057,519
G
Utp18
UTP18 small subunit processome component
increases expression
ISO
Benztropine results in increased expression of UTP18 protein
CTD
PMID:34122009
NCBI chr10:78,811,879...78,839,338
Ensembl chr10:78,811,880...78,839,627
G
Vasp
vasodilator-stimulated phosphoprotein
decreases expression
ISO
Benztropine results in decreased expression of VASP protein
CTD
PMID:34122009
NCBI chr 1:78,910,009...78,925,791
Ensembl chr 1:78,910,011...78,925,061
G
Wars1
tryptophanyl-tRNA synthetase 1
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of WARS1 protein
CTD
PMID:34122009
NCBI chr 6:127,776,088...127,807,273
Ensembl chr 6:127,776,090...127,807,269
G
Wdr12
WD repeat domain 12
decreases expression
ISO
Benztropine results in decreased expression of WDR12 protein
CTD
PMID:34122009
NCBI chr 9:61,475,498...61,502,762
Ensembl chr 9:61,475,517...61,502,469
G
Xirp2
xin actin-binding repeat containing 2
decreases expression
ISO
Benztropine results in decreased expression of XIRP2 protein
CTD
PMID:34122009
NCBI chr 3:52,126,213...52,213,094
Ensembl chr 3:51,870,092...52,213,091
G
Xpo7
exportin 7
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in increased expression of XPO7 protein
CTD
PMID:34122009
NCBI chr15:45,742,053...45,828,050
Ensembl chr15:45,742,053...45,828,050
G
Ywhaq
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
increases expression
ISO
Benztropine results in increased expression of YWHAQ protein
CTD
PMID:34122009
NCBI chr 6:40,935,714...40,966,240
Ensembl chr 6:40,935,949...40,966,273
G
Zbtb42
zinc finger and BTB domain containing 42
multiple interactions
ISO
[Cuprizone co-treated with Benztropine] results in decreased expression of ZBTB42 protein
CTD
PMID:34122009
NCBI chr 6:131,734,257...131,742,459
Ensembl chr 6:131,738,356...131,742,685
G
Zfr
zinc finger RNA binding protein
decreases expression
ISO
Benztropine results in decreased expression of ZFR protein
CTD
PMID:34122009
NCBI chr 2:61,137,611...61,200,322
Ensembl chr 2:61,137,611...61,200,322
G
Zkscan7
zinc finger with KRAB and SCAN domains 7
decreases expression
ISO
Benztropine results in decreased expression of ZKSCAN7 protein
CTD
PMID:34122009
NCBI chr 8:122,501,938...122,519,600
Ensembl chr 8:122,502,218...122,519,600
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all