Uso1 (USO1 vesicle transport factor) - Rat Genome Database

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Gene: Uso1 (USO1 vesicle transport factor) Rattus norvegicus
Analyze
Symbol: Uso1
Name: USO1 vesicle transport factor
RGD ID: 621604
Description: Involved in endoplasmic reticulum to Golgi vesicle-mediated transport; membrane fusion; and transcytosis. Predicted to be located in several cellular components, including Golgi apparatus; fibrillar center; and perinuclear region of cytoplasm. Predicted to be active in ER to Golgi transport vesicle membrane; Golgi stack; and endoplasmic reticulum. Orthologous to human USO1 (USO1 vesicle transport factor); PARTICIPATES IN Arf family mediated signaling pathway; INTERACTS WITH 2,4-dinitrotoluene; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: general vesicular transport factor p115; protein USO1 homolog; TAP; transcytosis associated protein; transcytosis-associated protein; USO1 homolog, vesicle docking protein; USO1 homolog, vesicle docking protein (yeast); USO1 vesicle docking protein homolog; USO1 vesicle docking protein homolog (yeast); Vdp; vesicle docking protein; vesicle docking protein, 115 kDa; vesicle-docking protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81416,150,921 - 16,216,389 (-)NCBIGRCr8
mRatBN7.21415,866,638 - 15,932,185 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1415,866,638 - 15,932,171 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1415,877,025 - 15,942,315 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01417,195,867 - 17,261,157 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01415,891,324 - 15,956,616 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01417,371,451 - 17,436,948 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1417,371,453 - 17,436,897 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01417,289,138 - 17,354,629 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41417,414,403 - 17,480,241 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11417,414,402 - 17,480,241 (-)NCBI
Celera1415,262,274 - 15,328,301 (-)NCBICelera
Cytogenetic Map14p22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cocaine  (EXP)
copper(II) sulfate  (ISO)
coumarin  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
deguelin  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
diuron  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fenthion  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gentamycin  (EXP)
glafenine  (EXP)
glyphosate  (ISO)
haloperidol  (ISO)
hypochlorous acid  (ISO)
irinotecan  (ISO)
ivermectin  (ISO)
Mesaconitine  (EXP)
methidathion  (ISO)
methimazole  (EXP)
nickel atom  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (EXP)
progesterone  (ISO)
propiconazole  (ISO)
rotenone  (ISO)
sodium arsenite  (EXP,ISO)
sulfadimethoxine  (EXP)
testosterone  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP,ISO)
titanium dioxide  (ISO)
triphenyl phosphate  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function
protein binding  (IPI,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transcytosis-associated protein (TAP)/p115 is a general fusion factor required for binding of vesicles to acceptor membranes. Barroso M, etal., Proc Natl Acad Sci U S A 1995 Jan 17;92(2):527-31.
2. The membrane-tethering protein p115 interacts with GBF1, an ARF guanine-nucleotide-exchange factor. Garcia-Mata R and Sztul E, EMBO Rep. 2003 Mar;4(3):320-5.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Identification of p115 as a PLCgamma1-binding protein and the role of Src homology domains of PLCgamma1 in the vesicular transport. Han SJ, etal., Biochem Biophys Res Commun 2003 Jan 17;300(3):649-55.
5. Cdc2 kinase directly phosphorylates the cis-Golgi matrix protein GM130 and is required for Golgi fragmentation in mitosis. Lowe M, etal., Cell 1998 Sep 18;94(6):783-93.
6. The mitotic phosphorylation cycle of the cis-Golgi matrix protein GM130. Lowe M, etal., J Cell Biol. 2000 Apr 17;149(2):341-56.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. The vesicle docking protein p115 binds GM130, a cis-Golgi matrix protein, in a mitotically regulated manner. Nakamura N, etal., Cell 1997 May 2;89(3):445-55.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. p115 is a general vesicular transport factor related to the yeast endoplasmic reticulum to Golgi transport factor Uso1p. Sapperstein SK, etal., Proc Natl Acad Sci U S A 1995 Jan 17;92(2):522-6.
14. The role of the tethering proteins p115 and GM130 in transport through the Golgi apparatus in vivo. Seemann J, etal., Mol Biol Cell. 2000 Feb;11(2):635-45.
15. Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115. Shorter J, etal., J Cell Biol 2002 Apr 1;157(1):45-62.
16. A novel 115-kD peripheral membrane protein is required for intercisternal transport in the Golgi stack. Waters MG, etal., J Cell Biol 1992 Sep;118(5):1015-26.
Additional References at PubMed
PMID:15800058   PMID:15878873   PMID:16641100   PMID:18434597   PMID:18504258   PMID:19946888   PMID:22658674   PMID:23185636   PMID:24625528   PMID:25406594   PMID:25468996  


Genomics

Comparative Map Data
Uso1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81416,150,921 - 16,216,389 (-)NCBIGRCr8
mRatBN7.21415,866,638 - 15,932,185 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1415,866,638 - 15,932,171 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1415,877,025 - 15,942,315 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01417,195,867 - 17,261,157 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01415,891,324 - 15,956,616 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01417,371,451 - 17,436,948 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1417,371,453 - 17,436,897 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01417,289,138 - 17,354,629 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41417,414,403 - 17,480,241 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11417,414,402 - 17,480,241 (-)NCBI
Celera1415,262,274 - 15,328,301 (-)NCBICelera
Cytogenetic Map14p22NCBI
USO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38475,724,577 - 75,814,286 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl475,724,577 - 75,814,286 (+)EnsemblGRCh38hg38GRCh38
GRCh37476,649,761 - 76,735,439 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36476,868,853 - 76,954,390 (+)NCBINCBI36Build 36hg18NCBI36
Build 34477,007,007 - 77,092,543NCBI
Celera473,946,229 - 74,035,768 (+)NCBICelera
Cytogenetic Map4q21.1NCBI
HuRef472,397,753 - 72,487,978 (+)NCBIHuRef
CHM1_1476,626,547 - 76,712,015 (+)NCBICHM1_1
T2T-CHM13v2.0479,064,705 - 79,154,419 (+)NCBIT2T-CHM13v2.0
Uso1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39592,285,770 - 92,350,659 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl592,285,797 - 92,350,657 (+)EnsemblGRCm39 Ensembl
GRCm38592,137,909 - 92,202,800 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl592,137,938 - 92,202,798 (+)EnsemblGRCm38mm10GRCm38
MGSCv37592,566,964 - 92,631,821 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36593,213,138 - 93,277,995 (+)NCBIMGSCv36mm8
Celera590,281,456 - 90,346,290 (+)NCBICelera
Cytogenetic Map5E2NCBI
cM Map546.05NCBI
Uso1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554741,647,361 - 1,705,548 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554741,647,670 - 1,704,869 (+)NCBIChiLan1.0ChiLan1.0
USO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2354,258,520 - 54,348,206 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1454,448,331 - 54,537,888 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0448,391,293 - 48,480,909 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1454,229,601 - 54,317,402 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl454,229,601 - 54,317,158 (-)Ensemblpanpan1.1panPan2
USO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.132305,895 - 395,113 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl32305,935 - 394,896 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3241,486,671 - 41,575,746 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.032330,513 - 419,681 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl32330,518 - 421,808 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.132326,480 - 415,549 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.032283,134 - 372,220 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03239,797,734 - 39,887,494 (-)NCBIUU_Cfam_GSD_1.0
Uso1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528511,719,761 - 11,754,982 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936598172,698 - 246,370 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936598172,360 - 246,565 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
USO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl871,363,614 - 71,452,939 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1871,363,627 - 71,451,258 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2875,499,566 - 75,587,277 (+)NCBISscrofa10.2Sscrofa10.2susScr3
USO1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1724,236,601 - 24,325,575 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl724,236,698 - 24,325,630 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660372,577,653 - 2,668,033 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Uso1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473028,175 - 130,012 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473027,313 - 130,086 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Uso1
326 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:341
Count of miRNA genes:218
Interacting mature miRNAs:257
Transcripts:ENSRNOT00000003277
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2300159Bmd61Bone mineral density QTL 615.30.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
2300183Bmd60Bone mineral density QTL 605.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)14126541967Rat
619619Rf4Renal disease susceptibility QTL 44.10.002urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)14132754612Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141131407Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14121760616960180Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)14381307418274691Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14381307418274691Rat
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14381307421217635Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14381307424531477Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14381307430767156Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14826709053267090Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14908897839057237Rat
2302277Gluco38Glucose level QTL 385.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062228035204Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)141103062295876975Rat
631212Bw5Body weight QTL55.43retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)141103081230320092Rat
1300140Srn3Serum renin concentration QTL 33.19blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)141487516830883947Rat

Markers in Region
D14Hmgc11  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21415,927,530 - 15,927,824 (+)MAPPERmRatBN7.2
Rnor_6.01417,432,320 - 17,432,613NCBIRnor6.0
Rnor_5.01417,349,999 - 17,350,292UniSTSRnor5.0
Celera1415,323,726 - 15,324,019UniSTS
Cytogenetic Map14p22UniSTS
D14Hmgc10  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21415,880,745 - 15,880,993 (+)MAPPERmRatBN7.2
Rnor_6.01417,385,559 - 17,385,806NCBIRnor6.0
Rnor_5.01417,303,246 - 17,303,493UniSTSRnor5.0
Celera1415,276,380 - 15,276,627UniSTS
Cytogenetic Map14p22UniSTS
D14Hmgc9  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21415,875,778 - 15,876,008 (+)MAPPERmRatBN7.2
Rnor_6.01417,380,592 - 17,380,821NCBIRnor6.0
Rnor_5.01417,298,279 - 17,298,508UniSTSRnor5.0
Celera1415,271,413 - 15,271,642UniSTS
Cytogenetic Map14p22UniSTS
RH140889  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21415,866,824 - 15,867,007 (+)MAPPERmRatBN7.2
Rnor_6.01417,371,638 - 17,371,820NCBIRnor6.0
Rnor_5.01417,289,325 - 17,289,507UniSTSRnor5.0
RGSC_v3.41417,414,588 - 17,414,770UniSTSRGSC3.4
Celera1415,262,459 - 15,262,641UniSTS
RH 3.4 Map14159.88UniSTS
Cytogenetic Map14p22UniSTS
BI277889  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21415,868,138 - 15,868,296 (+)MAPPERmRatBN7.2
Rnor_6.01417,372,952 - 17,373,109NCBIRnor6.0
Rnor_5.01417,290,639 - 17,290,796UniSTSRnor5.0
RGSC_v3.41417,415,902 - 17,416,059UniSTSRGSC3.4
Celera1415,263,773 - 15,263,930UniSTS
RH 3.4 Map14181.19UniSTS
Cytogenetic Map14p22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 40 11 8
Low 1
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000003277   ⟹   ENSRNOP00000003277
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1415,866,640 - 15,932,108 (-)Ensembl
Rnor_6.0 Ensembl1417,371,453 - 17,436,897 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103892   ⟹   ENSRNOP00000087182
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1415,866,638 - 15,932,171 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000110714   ⟹   ENSRNOP00000077073
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1415,866,640 - 15,932,108 (-)Ensembl
RefSeq Acc Id: NM_019379   ⟹   NP_062252
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81416,150,923 - 16,216,389 (-)NCBI
mRatBN7.21415,866,640 - 15,932,108 (-)NCBI
Rnor_6.01417,371,453 - 17,436,897 (-)NCBI
Rnor_5.01417,289,138 - 17,354,629 (-)NCBI
RGSC_v3.41417,414,403 - 17,480,241 (-)RGD
Celera1415,262,274 - 15,328,301 (-)RGD
Sequence:
RefSeq Acc Id: XM_006250750   ⟹   XP_006250812
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81416,150,921 - 16,216,367 (-)NCBI
mRatBN7.21415,866,638 - 15,932,185 (-)NCBI
Rnor_6.01417,371,451 - 17,436,948 (-)NCBI
Rnor_5.01417,289,138 - 17,354,629 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063273513   ⟹   XP_063129583
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81416,150,921 - 16,216,367 (-)NCBI
RefSeq Acc Id: XM_063273514   ⟹   XP_063129584
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81416,150,921 - 16,216,367 (-)NCBI
RefSeq Acc Id: NP_062252   ⟸   NM_019379
- UniProtKB: P41542 (UniProtKB/Swiss-Prot),   A6KKA4 (UniProtKB/TrEMBL),   A0A8I6A7H7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250812   ⟸   XM_006250750
- Peptide Label: isoform X1
- UniProtKB: A0A8L2Q065 (UniProtKB/TrEMBL),   A0A8I6A7H7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000003277   ⟸   ENSRNOT00000003277
RefSeq Acc Id: ENSRNOP00000087182   ⟸   ENSRNOT00000103892
RefSeq Acc Id: ENSRNOP00000077073   ⟸   ENSRNOT00000110714
RefSeq Acc Id: XP_063129584   ⟸   XM_063273514
- Peptide Label: isoform X3
- UniProtKB: A0A8I5Y5W3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063129583   ⟸   XM_063273513
- Peptide Label: isoform X2
- UniProtKB: A0A8I5Y5W3 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P41542-F1-model_v2 AlphaFold P41542 1-959 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699216
Promoter ID:EPDNEW_R9741
Type:initiation region
Name:Uso1_1
Description:USO1 vesicle transport factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01417,436,927 - 17,436,987EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621604 AgrOrtholog
BioCyc Gene G2FUF-16251 BioCyc
Ensembl Genes ENSRNOG00000002301 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003277.5 UniProtKB/TrEMBL
  ENSRNOT00000103892 ENTREZGENE
  ENSRNOT00000103892.1 UniProtKB/TrEMBL
  ENSRNOT00000110714.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Armadillo UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P115_Arm_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Uso1_p115_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Vesicle_Uso1_P115_head UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:56042 UniProtKB/Swiss-Prot
NCBI Gene 56042 ENTREZGENE
PANTHER GENERAL VESICULAR TRANSPORT FACTOR P115 UniProtKB/Swiss-Prot
  GENERAL VESICULAR TRANSPORT FACTOR P115 UniProtKB/Swiss-Prot
  GENERAL VESICULAR TRANSPORT FACTOR P115 UniProtKB/TrEMBL
  GENERAL VESICULAR TRANSPORT FACTOR P115 UniProtKB/TrEMBL
Pfam Arm_vescicular UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Uso1_p115_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Uso1_p115_head UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Uso1 PhenoGen
PROSITE ARM_REPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002301 RatGTEx
SMART ARM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5Y5W3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A7H7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q065 ENTREZGENE, UniProtKB/TrEMBL
  A6KKA4 ENTREZGENE, UniProtKB/TrEMBL
  P41542 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-12-18 Uso1  USO1 vesicle transport factor  Uso1  USO1 vesicle docking protein homolog (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-01 Uso1  USO1 vesicle docking protein homolog (yeast)  Uso1  USO1 homolog, vesicle docking protein (yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-25 Uso1  USO1 homolog, vesicle docking protein (yeast)  Vdp  vesicle docking protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Vdp  vesicle docking protein    vesicle docking protein, 115 kDa  Name updated 1299863 APPROVED
2002-08-07 Vdp        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction protein binds with Plcg1 (phospholipase C gamma 1) via the Plcg1 SH2 and SH3 domains 734467
gene_process involved with regulation of vesicle transport via its association with Plgc1 (phospholipase C gamma 1) 734467
gene_process required for vesicle binding to the plasma membrane in transcytosis 730003
gene_process may play a role in cis to medial Golgi transport 730003
gene_process may act to facilitate membrane fusion 730003