Metap2 (methionyl aminopeptidase 2) - Rat Genome Database

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Gene: Metap2 (methionyl aminopeptidase 2) Rattus norvegicus
Analyze
Symbol: Metap2
Name: methionyl aminopeptidase 2
RGD ID: 70995
Description: Predicted to enable aminopeptidase activity and metalloexopeptidase activity. Predicted to be involved in protein processing. Predicted to be located in cytosol and plasma membrane. Predicted to be active in cytoplasm. Orthologous to human METAP2 (methionyl aminopeptidase 2); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Amp2; initiation factor 2 associated 67 kDa protein; initiation factor 2-associated 67 kDa glycoprotein; MAP 2; metAP 2; methionine aminopeptidase; methionine aminopeptidase 2; Mnpep; p67; p67eIF2; peptidase M 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Metap2-ps1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8730,299,433 - 30,327,477 (-)NCBIGRCr8
mRatBN7.2728,412,429 - 28,440,458 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl728,411,608 - 28,440,434 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx730,402,812 - 30,430,792 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0732,565,048 - 32,593,032 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0732,342,482 - 32,370,504 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0734,762,241 - 34,789,456 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl734,762,231 - 34,789,479 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0734,821,214 - 34,848,430 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4730,974,071 - 31,001,641 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1730,994,341 - 31,021,912 (-)NCBI
Celera725,509,781 - 25,535,670 (-)NCBICelera
Cytogenetic Map7q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
2-methylcholine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
5-fluorouracil  (ISO)
acetamide  (EXP)
all-trans-retinoic acid  (ISO)
Allylamine  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
carbon nanotube  (ISO)
chloropicrin  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
Cuprizon  (ISO)
cyclosporin A  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
elemental selenium  (ISO)
Enterolactone  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fumagillin  (EXP,ISO)
furan  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
ivermectin  (ISO)
L-ethionine  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (ISO)
Mesaconitine  (EXP)
methylparaben  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nitroxoline  (ISO)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
pinosylvin  (ISO)
progesterone  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenite  (ISO)
temozolomide  (ISO)
tetrahydropalmatine  (ISO)
thioacetamide  (EXP)
topotecan  (EXP)
trans-pinosylvin  (ISO)
triazoles  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
uranium atom  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA,ISO,ISS)
cytosol  (ISO)
plasma membrane  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Gene Data Set MGD Curation, June 12, 2002
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. GOA pipeline RGD automated data pipeline
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
9. Cloning and characterization of complementary DNA encoding the eukaryotic initiation factor 2-associated 67-kDa protein (p67). Wu S, etal., J Biol Chem 1993 May 25;268(15):10796-81.
Additional References at PubMed
PMID:7644482   PMID:8858118   PMID:12581743   PMID:15102683   PMID:17446530   PMID:21033716   PMID:22658674  


Genomics

Comparative Map Data
Metap2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8730,299,433 - 30,327,477 (-)NCBIGRCr8
mRatBN7.2728,412,429 - 28,440,458 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl728,411,608 - 28,440,434 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx730,402,812 - 30,430,792 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0732,565,048 - 32,593,032 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0732,342,482 - 32,370,504 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0734,762,241 - 34,789,456 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl734,762,231 - 34,789,479 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0734,821,214 - 34,848,430 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4730,974,071 - 31,001,641 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1730,994,341 - 31,021,912 (-)NCBI
Celera725,509,781 - 25,535,670 (-)NCBICelera
Cytogenetic Map7q13NCBI
METAP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381295,474,152 - 95,515,839 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1295,473,520 - 95,515,839 (+)EnsemblGRCh38hg38GRCh38
GRCh371295,867,928 - 95,909,615 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361294,391,953 - 94,433,746 (+)NCBINCBI36Build 36hg18NCBI36
Build 341294,370,389 - 94,410,587NCBI
Celera1295,538,718 - 95,580,736 (+)NCBICelera
Cytogenetic Map12q22NCBI
HuRef1292,936,350 - 92,977,989 (+)NCBIHuRef
CHM1_11295,833,252 - 95,875,049 (+)NCBICHM1_1
T2T-CHM13v2.01295,455,178 - 95,496,879 (+)NCBIT2T-CHM13v2.0
Metap2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391093,694,351 - 93,732,952 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1093,694,351 - 93,732,955 (-)EnsemblGRCm39 Ensembl
GRCm381093,858,489 - 93,897,090 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1093,858,489 - 93,897,093 (-)EnsemblGRCm38mm10GRCm38
MGSCv371093,321,234 - 93,353,947 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361093,288,288 - 93,321,001 (-)NCBIMGSCv36mm8
Celera1095,828,659 - 95,861,285 (-)NCBICelera
Cytogenetic Map10C2NCBI
cM Map1048.69NCBI
Metap2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540531,942,427 - 31,976,678 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540531,942,427 - 31,976,678 (+)NCBIChiLan1.0ChiLan1.0
METAP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210103,548,786 - 103,590,522 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112103,545,904 - 103,586,912 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01293,068,921 - 93,109,098 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11296,461,418 - 96,503,087 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1296,461,549 - 96,503,508 (+)Ensemblpanpan1.1panPan2
METAP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11535,363,494 - 35,398,926 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1535,363,528 - 35,398,168 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1535,750,123 - 35,785,289 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01536,028,074 - 36,063,311 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1536,028,136 - 36,064,772 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11535,301,082 - 35,336,182 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01535,395,570 - 35,430,722 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01535,658,719 - 35,693,877 (+)NCBIUU_Cfam_GSD_1.0
Metap2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494524,573,140 - 24,610,683 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650711,624,060 - 11,660,875 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650711,624,696 - 11,661,632 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
METAP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl587,888,674 - 87,926,148 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1587,890,821 - 87,926,155 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2592,091,623 - 92,127,676 (-)NCBISscrofa10.2Sscrofa10.2susScr3
METAP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11190,872,672 - 90,914,257 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1190,872,699 - 90,912,499 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037154,255,439 - 154,297,723 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Metap2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475011,726,303 - 11,756,671 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Metap2
64 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:288
Count of miRNA genes:172
Interacting mature miRNAs:186
Transcripts:ENSRNOT00000030056, ENSRNOT00000031571
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71557388960573889Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)71700459862004598Rat
10755451Coatc11Coat color QTL 110coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)71794435762944357Rat
61369Mcs2Mammary carcinoma susceptibility QTL 23.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)71903280735526300Rat
1354637Scl30Serum cholesterol level QTL 303.7blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)71965431749753746Rat
1354644Spl4Serum phospholipid level QTL 44.9blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)71965431749753746Rat
1354639Spl5Serum phospholipid level QTL 53.9blood LDL phospholipid amount (VT:0010505)blood low density lipoprotein phospholipid level (CMO:0001568)71965431752888450Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)72055570529891047Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72673740163902784Rat

Markers in Region
AW529792  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2728,412,512 - 28,412,671 (+)MAPPERmRatBN7.2
Rnor_6.0734,761,972 - 34,762,130NCBIRnor6.0
Rnor_5.0734,820,945 - 34,821,103UniSTSRnor5.0
RGSC_v3.4730,973,802 - 30,973,960UniSTSRGSC3.4
Celera725,509,512 - 25,509,670UniSTS
RH 3.4 Map7192.1UniSTS
Cytogenetic Map7q13UniSTS
RH143662  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7q13UniSTS
RH135833  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21849,612,619 - 49,612,738 (+)MAPPERmRatBN7.2
mRatBN7.21233,108,263 - 233,108,380 (+)MAPPERmRatBN7.2
Rnor_6.01254,019,891 - 254,020,007NCBIRnor6.0
Rnor_6.01851,219,309 - 51,219,427NCBIRnor6.0
Rnor_5.01850,418,025 - 50,418,143UniSTSRnor5.0
Rnor_5.01261,237,751 - 261,237,867UniSTSRnor5.0
RGSC_v3.41239,602,208 - 239,602,324UniSTSRGSC3.4
RGSC_v3.41851,879,290 - 51,879,408UniSTSRGSC3.4
Celera1847,760,366 - 47,760,484UniSTS
Celera1230,211,792 - 230,211,908UniSTS
Cytogenetic Map7q13UniSTS
Cytogenetic Map1q53UniSTS
Cytogenetic Map18q12.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000030056   ⟹   ENSRNOP00000032680
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl728,412,781 - 28,440,434 (-)Ensembl
Rnor_6.0 Ensembl734,762,656 - 34,789,370 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000031571   ⟹   ENSRNOP00000030415
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl728,412,773 - 28,440,434 (-)Ensembl
Rnor_6.0 Ensembl734,762,231 - 34,789,479 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000110473   ⟹   ENSRNOP00000087571
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl728,411,608 - 28,440,434 (-)Ensembl
RefSeq Acc Id: NM_022539   ⟹   NP_071984
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8730,299,433 - 30,327,448 (-)NCBI
mRatBN7.2728,412,429 - 28,440,448 (-)NCBI
Rnor_6.0734,762,241 - 34,789,456 (-)NCBI
Rnor_5.0734,821,214 - 34,848,430 (-)NCBI
RGSC_v3.4730,974,071 - 31,001,641 (-)RGD
Celera725,509,781 - 25,535,670 (-)RGD
Sequence:
RefSeq Acc Id: XM_039079853   ⟹   XP_038935781
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8730,299,775 - 30,327,477 (-)NCBI
mRatBN7.2728,412,771 - 28,440,458 (-)NCBI
RefSeq Acc Id: XM_039079854   ⟹   XP_038935782
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8730,299,775 - 30,327,463 (-)NCBI
mRatBN7.2728,412,771 - 28,440,458 (-)NCBI
RefSeq Acc Id: NP_071984   ⟸   NM_022539
- UniProtKB: P38062 (UniProtKB/Swiss-Prot),   Q5BKA1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000030415   ⟸   ENSRNOT00000031571
RefSeq Acc Id: ENSRNOP00000032680   ⟸   ENSRNOT00000030056
RefSeq Acc Id: XP_038935782   ⟸   XM_039079854
- Peptide Label: isoform X2
- UniProtKB: P38062 (UniProtKB/Swiss-Prot),   F7FJ19 (UniProtKB/TrEMBL),   Q6IRK1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038935781   ⟸   XM_039079853
- Peptide Label: isoform X1
- UniProtKB: P38062 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSRNOP00000087571   ⟸   ENSRNOT00000110473
Protein Domains
Peptidase M24

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P38062-F1-model_v2 AlphaFold P38062 1-478 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695150
Promoter ID:EPDNEW_R5675
Type:initiation region
Name:Metap2_1
Description:methionyl aminopeptidase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0734,789,488 - 34,789,548EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70995 AgrOrtholog
BioCyc Gene G2FUF-34381 BioCyc
BioCyc Pathway PWY-7799 [Arg/N-end rule pathway (eukaryotic)] BioCyc
  PWY-7800 [Ac/N-end rule pathway] BioCyc
BioCyc Pathway Image PWY-7799 BioCyc
  PWY-7800 BioCyc
Ensembl Genes ENSRNOG00000021881 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000030056.7 UniProtKB/TrEMBL
  ENSRNOT00000031571.7 UniProtKB/TrEMBL
  ENSRNOT00000110473 ENTREZGENE
  ENSRNOT00000110473.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.230.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7099147 IMAGE-MGC_LOAD
  IMAGE:7122560 IMAGE-MGC_LOAD
InterPro Creatinase/aminopeptidase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M24 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M24_MAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M24A_MAP2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pept_M24A_MAP2_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64370 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:108689 IMAGE-MGC_LOAD
  MGC:91685 IMAGE-MGC_LOAD
NCBI Gene 64370 ENTREZGENE
PANTHER METHIONINE AMINOPEPTIDASE 2 UniProtKB/Swiss-Prot
  METHIONINE AMINOPEPTIDASE 2 UniProtKB/Swiss-Prot
  METHIONINE AMINOPEPTIDASE 2 UniProtKB/TrEMBL
  METHIONINE AMINOPEPTIDASE 2 UniProtKB/TrEMBL
Pfam Peptidase_M24 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Metap2 PhenoGen
PRINTS MAPEPTIDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MAP_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000021881 RatGTEx
Superfamily-SCOP SSF46785 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55920 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A902_RAT UniProtKB/TrEMBL
  A6IFZ5_RAT UniProtKB/TrEMBL
  F1LRI8_RAT UniProtKB/TrEMBL
  F7FJ19 ENTREZGENE
  MAP2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5BKA1 ENTREZGENE, UniProtKB/TrEMBL
  Q6IRK1 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F7FJ19 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-24 Metap2  methionyl aminopeptidase 2  Metap2  methionine aminopeptidase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Metap2  methionine aminopeptidase 2      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains a highly charged N-terminal region with two basic polylysine blocks and an acidic aspartic acid block 70793
gene_protein 480 amino acids 70793