Prkar2a (protein kinase cAMP-dependent type II regulatory subunit alpha) - Rat Genome Database

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Gene: Prkar2a (protein kinase cAMP-dependent type II regulatory subunit alpha) Rattus norvegicus
Analyze
Symbol: Prkar2a
Name: protein kinase cAMP-dependent type II regulatory subunit alpha
RGD ID: 3393
Description: Enables several functions, including beta-2 adrenergic receptor binding activity; cAMP binding activity; and cAMP-dependent protein kinase regulator activity. Involved in regulation of protein kinase activity. Located in T-tubule and perinuclear region of cytoplasm. Part of cAMP-dependent protein kinase complex. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human PRKAR2A (protein kinase cAMP-dependent type II regulatory subunit alpha); PARTICIPATES IN protein kinase A (PKA) signaling pathway; apoptotic cell death pathway; insulin signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cAMP-dependent protein kinase type II-alpha regulatory subunit; protein kinase cAMP-dependent regulatory type II alpha; protein kinase cAMP-dependent type 2 regulatory subunit alpha; protein kinase, cAMP dependent regulatory, type II alpha; protein kinase, cAMP-dependent, regulatory subunit type II alpha; protein kinase, cAMP-dependent, regulatory, type 2, alpha; protein kinase, cAMP-dependent, regulatory, type II, alpha
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88118,271,608 - 118,337,332 (+)NCBIGRCr8
mRatBN7.28109,393,189 - 109,458,832 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8109,395,833 - 109,455,628 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8115,013,927 - 115,072,982 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08113,213,100 - 113,272,156 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08111,055,904 - 111,114,960 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08117,486,085 - 117,548,768 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,486,083 - 117,546,370 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08116,830,841 - 116,893,276 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48113,746,384 - 113,805,476 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18113,765,838 - 113,824,931 (+)NCBI
Celera8108,691,132 - 108,750,351 (+)NCBICelera
RH 3.4 Map81114.1RGD
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2-ethoxyethanol  (EXP)
2-methoxyethanol  (EXP)
3',5'-cyclic AMP  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-vinylcyclohexene dioxide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
actinomycin D  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amphetamine  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bromuconazole  (EXP)
C60 fullerene  (EXP)
cadmium dichloride  (EXP)
caffeine  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
choline  (ISO)
clozapine  (EXP,ISO)
cobalt dichloride  (ISO)
colforsin daropate hydrochloride  (ISO)
Cuprizon  (ISO)
deoxynivalenol  (ISO)
diazinon  (EXP)
dibutyl phthalate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
folic acid  (ISO)
FR900359  (ISO)
genistein  (ISO)
haloperidol  (EXP,ISO)
ivermectin  (ISO)
L-methionine  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methoxychlor  (EXP)
monocrotaline  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-nitrosodiethylamine  (EXP)
Nutlin-3  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenethyl caffeate  (EXP)
phenylpropanolamine  (EXP)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
testosterone  (ISO)
testosterone enanthate  (EXP,ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Association of dystrobrevin and regulatory subunit of protein kinase A: a new role for dystrobrevin as a scaffold for signaling proteins. Ceccarini M, etal., J Mol Biol. 2007 Aug 31;371(5):1174-87. doi: 10.1016/j.jmb.2007.06.019. Epub 2007 Jun 14.
2. Small molecule AKAP-protein kinase A (PKA) interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes. Christian F, etal., J Biol Chem. 2011 Mar 18;286(11):9079-96. doi: 10.1074/jbc.M110.160614. Epub 2010 Dec 22.
3. Differential effects of haloperidol and clozapine on cAMP binding, protein kinase A (PKA) activity, and mRNA and protein expression of selective regulatory and catalytic subunit isoforms of PKA in rat brain. Dwivedi Y, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):197-209.
4. Yotiao protein, a ligand for the NMDA receptor, binds and targets cAMP-dependent protein kinase II(1). Feliciello A, etal., FEBS Lett 1999 Dec 31;464(3):174-8.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Beta-adrenergic regulation requires direct anchoring of PKA to cardiac CaV1.2 channels via a leucine zipper interaction with A kinase-anchoring protein 15. Hulme JT, etal., Proc Natl Acad Sci U S A 2003 Oct 28;100(22):13093-8. Epub 2003 Oct 20.
8. Glycogen synthase kinase 3beta interaction protein functions as an A-kinase anchoring protein. Hundsrucker C, etal., J Biol Chem. 2010 Feb 19;285(8):5507-21. doi: 10.1074/jbc.M109.047944. Epub 2009 Dec 11.
9. A dynamic mechanism for AKAP binding to RII isoforms of cAMP-dependent protein kinase. Kinderman FS, etal., Mol Cell. 2006 Nov 3;24(3):397-408.
10. An active protein kinase A (PKA) is involved in meiotic arrest of rat growing oocytes. Kovo M, etal., Reproduction. 2006 Jul;132(1):33-43.
11. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
12. Phosphorylation of the cAMP-dependent protein kinase (PKA) regulatory subunit modulates PKA-AKAP interaction, substrate phosphorylation, and calcium signaling in cardiac cells. Manni S, etal., J Biol Chem. 2008 Aug 29;283(35):24145-54. Epub 2008 Jun 12.
13. PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Marx SO, etal., Cell. 2000 May 12;101(4):365-76.
14. Spatial organisation of AKAP18 and PDE4 isoforms in renal collecting duct principal cells. McSorley T, etal., Eur J Cell Biol. 2006 Jul;85(7):673-8. Epub 2006 Feb 28.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. The mAKAP complex participates in the induction of cardiac myocyte hypertrophy by adrenergic receptor signaling. Pare GC, etal., J Cell Sci. 2005 Dec 1;118(Pt 23):5637-46.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. GOA pipeline RGD automated data pipeline
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. The molecular cloning of a type II regulatory subunit of the cAMP-dependent protein kinase from rat skeletal muscle and mouse brain. Scott JD, etal., Proc Natl Acad Sci U S A 1987 Aug;84(15):5192-6.
22. Localized effects of cAMP mediated by distinct routes of protein kinase A. Tasken K and Aandahl EM, Physiol Rev. 2004 Jan;84(1):137-67.
23. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
24. Myomegalin is a novel A-kinase anchoring protein involved in the phosphorylation of cardiac myosin binding protein C. Uys GM, etal., BMC Cell Biol. 2011 May 10;12:18. doi: 10.1186/1471-2121-12-18.
25. Binding of amyloid beta peptide to beta2 adrenergic receptor induces PKA-dependent AMPA receptor hyperactivity. Wang D, etal., FASEB J. 2010 Sep;24(9):3511-21. doi: 10.1096/fj.10-156661. Epub 2010 Apr 15.
Additional References at PubMed
PMID:12475942   PMID:15255994   PMID:16641100   PMID:17911601   PMID:19056867   PMID:19946888   PMID:20458337   PMID:21399614   PMID:21423175   PMID:21423176   PMID:21502359   PMID:21812984  
PMID:22674394   PMID:23426434   PMID:23533145   PMID:24413018   PMID:24501172   PMID:25097019   PMID:29615473   PMID:30053369  


Genomics

Comparative Map Data
Prkar2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88118,271,608 - 118,337,332 (+)NCBIGRCr8
mRatBN7.28109,393,189 - 109,458,832 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8109,395,833 - 109,455,628 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8115,013,927 - 115,072,982 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08113,213,100 - 113,272,156 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08111,055,904 - 111,114,960 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08117,486,085 - 117,548,768 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8117,486,083 - 117,546,370 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08116,830,841 - 116,893,276 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48113,746,384 - 113,805,476 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18113,765,838 - 113,824,931 (+)NCBI
Celera8108,691,132 - 108,750,351 (+)NCBICelera
RH 3.4 Map81114.1RGD
Cytogenetic Map8q32NCBI
PRKAR2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38348,744,591 - 48,847,874 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl348,744,597 - 48,847,874 (-)EnsemblGRCh38hg38GRCh38
GRCh37348,784,019 - 48,885,307 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36348,763,097 - 48,860,274 (-)NCBINCBI36Build 36hg18NCBI36
Build 34348,763,096 - 48,860,274NCBI
Celera348,744,318 - 48,841,506 (-)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef348,846,714 - 48,943,468 (-)NCBIHuRef
CHM1_1348,740,185 - 48,837,372 (-)NCBICHM1_1
T2T-CHM13v2.0348,773,615 - 48,876,846 (-)NCBIT2T-CHM13v2.0
Prkar2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399108,569,342 - 108,627,643 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9108,566,513 - 108,627,635 (+)EnsemblGRCm39 Ensembl
GRCm389108,692,143 - 108,750,444 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9108,689,314 - 108,750,436 (+)EnsemblGRCm38mm10GRCm38
MGSCv379108,594,474 - 108,651,843 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369108,549,547 - 108,606,735 (+)NCBIMGSCv36mm8
Celera9108,299,573 - 108,356,490 (+)NCBICelera
Cytogenetic Map9F2NCBI
cM Map959.63NCBI
Prkar2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955532827,418 - 852,845 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955532827,112 - 896,487 (-)NCBIChiLan1.0ChiLan1.0
PRKAR2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2248,719,302 - 48,828,170 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1348,724,070 - 48,832,762 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0348,665,421 - 48,774,111 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1349,747,611 - 49,854,382 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl349,747,611 - 49,854,382 (-)Ensemblpanpan1.1panPan2
PRKAR2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12040,277,655 - 40,388,156 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2040,277,906 - 40,384,633 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2040,194,965 - 40,305,481 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02040,762,529 - 40,873,645 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2040,633,410 - 40,873,638 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12040,000,705 - 40,111,226 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02040,404,451 - 40,515,285 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02040,685,401 - 40,796,977 (+)NCBIUU_Cfam_GSD_1.0
Prkar2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560263,767,658 - 63,840,539 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936529528,114 - 601,122 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936529528,138 - 601,078 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKAR2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1331,426,213 - 31,517,122 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11331,427,786 - 31,517,005 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21334,688,004 - 34,770,648 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRKAR2A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12210,153,951 - 10,251,438 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2210,150,378 - 10,251,397 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041156,838,051 - 156,931,070 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prkar2a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247302,743,921 - 2,807,270 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prkar2a
483 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:41
Count of miRNA genes:37
Interacting mature miRNAs:41
Transcripts:ENSRNOT00000027552
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat

Markers in Region
RH94488  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28109,455,412 - 109,455,518 (+)MAPPERmRatBN7.2
Rnor_6.08117,545,349 - 117,545,454NCBIRnor6.0
Rnor_5.08116,889,857 - 116,889,962UniSTSRnor5.0
RGSC_v3.48113,805,261 - 113,805,366UniSTSRGSC3.4
Celera8108,750,136 - 108,750,241UniSTS
RH 3.4 Map81114.1UniSTS
Cytogenetic Map8q32UniSTS
RH137430  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28109,445,864 - 109,446,055 (+)MAPPERmRatBN7.2
Rnor_6.08117,536,107 - 117,536,297NCBIRnor6.0
Rnor_5.08116,881,290 - 116,881,480UniSTSRnor5.0
RGSC_v3.48113,796,199 - 113,796,389UniSTSRGSC3.4
Celera8108,741,238 - 108,741,428UniSTS
RH 3.4 Map81117.3UniSTS
Cytogenetic Map8q32UniSTS
AU049136  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28109,401,109 - 109,401,291 (+)MAPPERmRatBN7.2
Rnor_6.08117,491,359 - 117,491,540NCBIRnor6.0
Rnor_5.08116,836,213 - 116,836,394UniSTSRnor5.0
RGSC_v3.48113,751,660 - 113,751,841UniSTSRGSC3.4
Celera8108,696,406 - 108,696,591UniSTS
Cytogenetic Map8q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000027552   ⟹   ENSRNOP00000027552
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8109,395,833 - 109,455,628 (+)Ensembl
Rnor_6.0 Ensembl8117,486,083 - 117,545,564 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000088705   ⟹   ENSRNOP00000072848
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8109,395,833 - 109,455,628 (+)Ensembl
Rnor_6.0 Ensembl8117,486,158 - 117,546,370 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099199   ⟹   ENSRNOP00000090334
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8109,395,833 - 109,455,628 (+)Ensembl
RefSeq Acc Id: NM_019264   ⟹   NP_062137
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,274,348 - 118,334,133 (+)NCBI
mRatBN7.28109,395,835 - 109,455,628 (+)NCBI
Rnor_6.08117,486,085 - 117,545,564 (+)NCBI
Rnor_5.08116,830,841 - 116,893,276 (+)NCBI
RGSC_v3.48113,746,384 - 113,805,476 (+)RGD
Celera8108,691,132 - 108,750,351 (+)RGD
Sequence:
RefSeq Acc Id: XM_039080973   ⟹   XP_038936901
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88118,271,608 - 118,337,332 (+)NCBI
mRatBN7.28109,393,189 - 109,458,832 (+)NCBI
RefSeq Acc Id: NP_062137   ⟸   NM_019264
- UniProtKB: Q8K1M2 (UniProtKB/Swiss-Prot),   G3V8Q6 (UniProtKB/Swiss-Prot),   P12368 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072848   ⟸   ENSRNOT00000088705
Ensembl Acc Id: ENSRNOP00000027552   ⟸   ENSRNOT00000027552
RefSeq Acc Id: XP_038936901   ⟸   XM_039080973
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000090334   ⟸   ENSRNOT00000099199
Protein Domains
Cyclic nucleotide-binding   RIIa

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P12368-F1-model_v2 AlphaFold P12368 1-401 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3393 AgrOrtholog
BioCyc Gene G2FUF-29117 BioCyc
Ensembl Genes ENSRNOG00000020284 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055006869 UniProtKB/Swiss-Prot
  ENSRNOG00060028005 UniProtKB/Swiss-Prot
  ENSRNOG00065006794 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000027552.4 UniProtKB/Swiss-Prot
  ENSRNOT00000088705.2 UniProtKB/TrEMBL
  ENSRNOT00000099199.1 UniProtKB/TrEMBL
  ENSRNOT00055011315 UniProtKB/Swiss-Prot
  ENSRNOT00060048689 UniProtKB/Swiss-Prot
  ENSRNOT00065010568 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.120.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro cAMP-dep_kinase_reg_chain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cAMP_dep_PK_reg_su UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cAMP_dep_PK_reg_su_I/II_a/b UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29699 UniProtKB/Swiss-Prot
NCBI Gene 29699 ENTREZGENE
PANTHER CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CAMP-DEPENDENT PROTEIN KINASE TYPE II-ALPHA REGULATORY SUBUNIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam cNMP_binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIIa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Prkar2a PhenoGen
PIRSF PK_regulatory UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS CAMPKINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CNMP_BINDING_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CNMP_BINDING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CNMP_BINDING_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020284 RatGTEx
  ENSRNOG00055006869 RatGTEx
  ENSRNOG00060028005 RatGTEx
  ENSRNOG00065006794 RatGTEx
SMART cNMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIIa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51206 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC218654
UniProt A0A0G2K405_RAT UniProtKB/TrEMBL
  A0A8I6AE62_RAT UniProtKB/TrEMBL
  A6I379_RAT UniProtKB/TrEMBL
  A6I381_RAT UniProtKB/TrEMBL
  G3V8Q6 ENTREZGENE
  KAP2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q8K1M2 ENTREZGENE
UniProt Secondary G3V8Q6 UniProtKB/Swiss-Prot
  Q8K1M2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-03 Prkar2a  protein kinase cAMP-dependent type II regulatory subunit alpha  Prkar2a  protein kinase cAMP-dependent type 2 regulatory subunit alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-03 Prkar2a  protein kinase cAMP-dependent type 2 regulatory subunit alpha  Prkar2a  protein kinase, cAMP-dependent, regulatory subunit type II alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-11-30 Prkar2a  protein kinase, cAMP-dependent, regulatory subunit type II alpha  Prkar2a  protein kinase, cAMP dependent regulatory, type II alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-15 Prkar2a  protein kinase, cAMP dependent regulatory, type II alpha  Prkar2a  protein kinase, cAMP-dependent, regulatory, type 2, alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Prkar2a  protein kinase, cAMP-dependent, regulatory, type 2, alpha      Symbol and Name status set to approved 1299863 APPROVED
2002-06-10 Prkar2a  protein kinase, cAMP-dependent, regulatory, type 2, alpha      Name updated 70585 PROVISIONAL