Serpinb3a (serpin family B member 3A) - Rat Genome Database

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Gene: Serpinb3a (serpin family B member 3A) Rattus norvegicus
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Symbol: Serpinb3a
Name: serpin family B member 3A
RGD ID: 1562868
Description: Predicted to enable protease binding activity and serine-type endopeptidase inhibitor activity. Predicted to be involved in protection from natural killer cell mediated cytotoxicity. Predicted to be located in cytosol and plasma membrane. Predicted to be active in extracellular space. Orthologous to several human genes including SERPINB4 (serpin family B member 4); PARTICIPATES IN Entamoebiasis pathway; INTERACTS WITH bisphenol A; 17beta-estradiol (ortholog); 2,3,7,8-tetrachlorodibenzodioxine (ortholog).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC498209; RGD1562868; serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A; serpin B4-like; similar to squamous cell carcinoma antigen 2
RGD Orthologs
Human
Mouse
Bonobo
Pig
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81323,755,690 - 23,766,188 (-)NCBIGRCr8
mRatBN7.21323,241,303 - 23,246,328 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1323,236,972 - 23,246,985 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01327,153,500 - 27,159,319 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1327,153,925 - 27,158,628 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01332,303,013 - 32,307,716 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41313,305,950 - 13,311,099 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1323,086,931 - 23,092,755 (-)NCBICelera
Cytogenetic Map13p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12949073   PMID:21857942   PMID:23376485   PMID:23382074  


Genomics

Comparative Map Data
Serpinb3a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81323,755,690 - 23,766,188 (-)NCBIGRCr8
mRatBN7.21323,241,303 - 23,246,328 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1323,236,972 - 23,246,985 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01327,153,500 - 27,159,319 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1327,153,925 - 27,158,628 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01332,303,013 - 32,307,716 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41313,305,950 - 13,311,099 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1323,086,931 - 23,092,755 (-)NCBICelera
Cytogenetic Map13p11NCBI
SERPINB4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381863,637,259 - 63,644,256 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1863,637,259 - 63,644,256 (-)EnsemblGRCh38hg38GRCh38
GRCh371861,304,493 - 61,311,490 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361859,455,473 - 59,462,482 (-)NCBINCBI36Build 36hg18NCBI36
Build 341859,455,481 - 59,462,470NCBI
Celera1858,024,988 - 58,031,997 (-)NCBICelera
Cytogenetic Map18q21.33NCBI
HuRef1858,004,325 - 58,011,334 (-)NCBIHuRef
CHM1_11861,300,680 - 61,307,689 (-)NCBICHM1_1
T2T-CHM13v2.01863,842,341 - 63,849,338 (-)NCBIT2T-CHM13v2.0
Serpinb3a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391106,973,317 - 106,980,033 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1106,973,317 - 106,980,033 (-)EnsemblGRCm39 Ensembl
GRCm381107,045,587 - 107,052,303 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1107,045,587 - 107,052,303 (-)EnsemblGRCm38mm10GRCm38
MGSCv371108,942,164 - 108,948,880 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361108,873,152 - 108,879,850 (-)NCBIMGSCv36mm8
Celera1109,893,780 - 109,900,500 (-)NCBICelera
Cytogenetic Map1E2.1NCBI
cM Map150.34NCBI
SERPINB4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21781,147,887 - 81,154,885 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11866,840,498 - 66,847,496 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01856,996,437 - 57,003,489 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11860,308,357 - 60,312,884 (-)NCBIpanpan1.1PanPan1.1panPan2
LOC100153783
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11157,922,639 - 157,937,650 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21175,446,421 - 175,466,876 (+)NCBISscrofa10.2Sscrofa10.2susScr3

Variants

.
Variants in Serpinb3a
207 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:28
Count of miRNA genes:28
Interacting mature miRNAs:28
Transcripts:ENSRNOT00000003475
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317027Aia22Adjuvant induced arthritis QTL 222.29joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)13134266636Rat
738036Lnnr4Liver neoplastic nodule remodeling QTL 43.64liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)13142356786Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
631672Iddm12Insulin dependent diabetes mellitus QTL 122.20.0032blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)13599466834535351Rat
61339Bp24Blood pressure QTL 240.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)13599466844807491Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13599483377046787Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7411662Foco29Food consumption QTL 2920.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)13931346554313465Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2317046Aia8Adjuvant induced arthritis QTL 83.9700000286102295joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
2317034Aia9Adjuvant induced arthritis QTL 94.62joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)131176653532331607Rat
2317044Aia23Adjuvant induced arthritis QTL 232.3joint integrity trait (VT:0010548)ankle joint diameter (CMO:0002148)131176653532331607Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131192944945417941Rat
2302275Gluco37Glucose level QTL 373.8blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)131192944946193066Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat
9589164Gluco66Glucose level QTL 666.670.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)131515872260158722Rat
1331784Bp222Blood pressure QTL 2222.944arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131769443653050594Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
70170Eae14Experimental allergic encephalomyelitis QTL 140.0024nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)132320344868203448Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system appendage
High
Medium 6
Low 11 2 7 2 7 1
Below cutoff 2 5 4 3 4 2 2 2 11 1 2

Sequence


RefSeq Acc Id: ENSRNOT00000003475   ⟹   ENSRNOP00000003475
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1327,153,925 - 27,158,628 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000098658   ⟹   ENSRNOP00000090184
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1323,241,054 - 23,246,179 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000111925   ⟹   ENSRNOP00000093380
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1323,241,054 - 23,246,882 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000118881   ⟹   ENSRNOP00000077828
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1323,236,972 - 23,246,985 (-)Ensembl
RefSeq Acc Id: XM_006249640   ⟹   XP_006249702
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81323,755,690 - 23,760,970 (-)NCBI
mRatBN7.21323,241,303 - 23,246,328 (-)NCBI
Rnor_6.01327,153,500 - 27,159,319 (-)NCBI
Rnor_5.01332,303,013 - 32,307,716 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063272666   ⟹   XP_063128736
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81323,755,690 - 23,766,188 (-)NCBI
Protein Sequences
Protein RefSeqs XP_006249702 (Get FASTA)   NCBI Sequence Viewer  
  XP_063128736 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000077828.1
  ENSRNOP00000090184.1
  ENSRNOP00000093380
  ENSRNOP00000093380.1
RefSeq Acc Id: XP_006249702   ⟸   XM_006249640
- UniProtKB: A0A8I6AJJ4 (UniProtKB/TrEMBL),   A0A8I6ADB0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000003475   ⟸   ENSRNOT00000003475
RefSeq Acc Id: ENSRNOP00000090184   ⟸   ENSRNOT00000098658
RefSeq Acc Id: ENSRNOP00000077828   ⟸   ENSRNOT00000118881
RefSeq Acc Id: ENSRNOP00000093380   ⟸   ENSRNOT00000111925
RefSeq Acc Id: XP_063128736   ⟸   XM_063272666
- UniProtKB: A0A8I6AJJ4 (UniProtKB/TrEMBL)
Protein Domains
SERPIN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZJK2-F1-model_v2 AlphaFold D3ZJK2 1-387 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562868 AgrOrtholog
BioCyc Gene G2FUF-18597 BioCyc
Ensembl Genes ENSRNOG00000002578 Ensembl
  ENSRNOG00000066913 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000098658.1 UniProtKB/TrEMBL
  ENSRNOT00000111925.1 UniProtKB/TrEMBL
  ENSRNOT00000118881.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.39.10 UniProtKB/TrEMBL
  3.30.497.10 UniProtKB/TrEMBL
InterPro Protease_inhib_I4_serpin UniProtKB/TrEMBL
  Protease_inhib_I4_serpin_CS UniProtKB/TrEMBL
  Sepin_dom UniProtKB/TrEMBL
  Serpin_sf UniProtKB/TrEMBL
  Serpin_sf_1 UniProtKB/TrEMBL
  Serpin_sf_2 UniProtKB/TrEMBL
KEGG Report rno:498209 UniProtKB/TrEMBL
NCBI Gene 498209 ENTREZGENE
PANTHER Prot_inh_serpin UniProtKB/TrEMBL
  SERPIN B4 UniProtKB/TrEMBL
Pfam Serpin UniProtKB/TrEMBL
PhenoGen Serpinb3a PhenoGen
PROSITE SERPIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002578 RatGTEx
  ENSRNOG00000066913 RatGTEx
SMART SERPIN UniProtKB/TrEMBL
Superfamily-SCOP Prot_inh_serpin UniProtKB/TrEMBL
UniProt A0A8I5ZJL2_RAT UniProtKB/TrEMBL
  A0A8I6ADB0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AJJ4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Serpinb3a  serpin family B member 3A  Serpinb3a  serpin family B member 3A  Data merged from RGD:149736420 737654 PROVISIONAL
2021-08-09 Serpinb3a  serpin family B member 3A      Symbol and Name status set to provisional 45752 PROVISIONAL
2020-08-13 Serpinb3a  serpin family B member 3A  Serpinb3a  serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Serpinb3a  serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A  RGD1562868_predicted  similar to squamous cell carcinoma antigen 2 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1562868_predicted  similar to squamous cell carcinoma antigen 2 (predicted)  LOC498209  similar to squamous cell carcinoma antigen 2  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498209  similar to squamous cell carcinoma antigen 2      Symbol and Name status set to provisional 70820 PROVISIONAL