Kif5c (kinesin family member 5C) - Rat Genome Database

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Gene: Kif5c (kinesin family member 5C) Rattus norvegicus
Analyze
Symbol: Kif5c
Name: kinesin family member 5C
RGD ID: 1308539
Description: Enables ATP hydrolysis activity; apolipoprotein receptor binding activity; and microtubule binding activity. Involved in anterograde axonal protein transport and intracellular mRNA localization. Located in dendrite. Is active in GABA-ergic synapse and postsynaptic cytosol. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 2 and schizophrenia. Orthologous to human KIF5C (kinesin family member 5C); PARTICIPATES IN mitochondria transport pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; alpha-Zearalanol; bis(2-ethylhexyl) phthalate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: kinesin heavy chain; kinesin heavy chain isoform 5C; kinesin heavy chain neuron-specific 2; kinesin-1; LOC311024
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8354,441,266 - 54,591,630 (+)NCBIGRCr8
mRatBN7.2334,032,082 - 34,185,597 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl334,032,105 - 34,182,413 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx337,402,568 - 37,553,043 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0345,987,291 - 46,137,761 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0343,799,352 - 43,950,019 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0335,014,157 - 35,257,417 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl335,014,538 - 35,257,407 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0340,150,177 - 40,380,889 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4330,602,210 - 30,755,482 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1330,498,932 - 30,637,511 (+)NCBI
Celera332,217,717 - 32,366,850 (+)NCBICelera
Cytogenetic Map3q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
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Original Reference(s)
Kif5cRatAlzheimer's disease 3  ISOKIF5C (Homo sapiens)12859086protein:decreased expression:cerebellum (human)RGD 
Kif5cRatamyotrophic lateral sclerosis type 1  ISOKif5c (Mus musculus)12798528mRNA:increased expression:frontal cortex and cerebellum (mouse)RGD 
Kif5cRatleiomyoma  ISOKIF5C (Homo sapiens)12859089mRNA:increased expression:myometrium (human)RGD 
Kif5cRatschizophrenia  ISOKIF5C (Homo sapiens)12859088DNA:snp:enhancer:T>C (rs10929935) (human)RGD 
Object Symbol
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Original Reference(s)
Kif5cRatautosomal dominant intellectual developmental disorder 1  ISOKIF5C (Homo sapiens)8554872ClinVar more ...ClinVarPMID:19904302 more ...
Kif5cRatcomplex cortical dysplasia with other brain malformations  ISOKIF5C (Homo sapiens)8554872ClinVar Annotator: match by term: Cortical dysplasiaClinVarPMID:25741868 and PMID:27391121
Kif5cRatcomplex cortical dysplasia with other brain malformations 2  ISOKIF5C (Homo sapiens)8554872ClinVar more ...ClinVarPMID:23033978 more ...
Kif5cRatDevelopmental Disease  ISOKIF5C (Homo sapiens)8554872ClinVar Annotator: match by term: Developmental disorderClinVarPMID:25741868
Kif5cRatDuane retraction syndrome  ISOKIF5C (Homo sapiens)8554872ClinVar Annotator: match by term: Duane retraction syndromeClinVarPMID:25741868
Kif5cRatgenetic disease  ISOKIF5C (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVar 
Kif5cRatjaw-winking syndrome  ISOKIF5C (Homo sapiens)8554872ClinVar Annotator: match by term: Jaw-winking syndromeClinVarPMID:25741868
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Original Reference(s)
Kif5cRatcomplex cortical dysplasia with other brain malformations  ISOKIF5C (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23603762
Kif5cRatmicrocephaly  ISOKIF5C (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23603762
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Original Reference(s)
Kif5cRatcomplex cortical dysplasia with other brain malformations 2  ISOKIF5C (Homo sapiens)7240710 OMIM 

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Original Reference(s)
Kif5cRat1,2-dimethylhydrazine multiple interactionsISOKif5c (Mus musculus)6480464Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in decreased expression of KIF5C mRNA]CTDPMID:22206623
Kif5cRat1,2-dimethylhydrazine decreases expressionISOKif5c (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of KIF5C mRNACTDPMID:22206623
Kif5cRat17alpha-ethynylestradiol multiple interactionsISOKif5c (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of KIF5C mRNACTDPMID:17942748
Kif5cRat17beta-estradiol multiple interactionsISOKIF5C (Homo sapiens)6480464[Estradiol co-treated with TGFB1 protein] results in increased expression of KIF5C mRNACTDPMID:30165855
Kif5cRat17beta-hydroxy-5alpha-androstan-3-one increases expressionISOKIF5C (Homo sapiens)6480464Dihydrotestosterone results in increased expression of KIF5C mRNACTDPMID:29581250
Kif5cRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOKif5c (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of KIF5C mRNACTDPMID:17942748
Kif5cRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of KIF5C mRNACTDPMID:34747641
Kif5cRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOKif5c (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of KIF5C mRNACTDPMID:21570461
Kif5cRat3,4-methylenedioxymethamphetamine increases expressionISOKif5c (Mus musculus)6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of KIF5C mRNACTDPMID:20188158
Kif5cRat8-Br-cAMP increases expressionISOKIF5C (Homo sapiens)64804648-Bromo Cyclic Adenosine Monophosphate results in increased expression of KIF5C mRNACTDPMID:22079614
Kif5cRataflatoxin B1 decreases methylationISOKIF5C (Homo sapiens)6480464Aflatoxin B1 results in decreased methylation of KIF5C geneCTDPMID:27153756
Kif5cRatall-trans-retinoic acid decreases expressionISOKIF5C (Homo sapiens)6480464Tretinoin results in decreased expression of KIF5C mRNACTDPMID:21934132
Kif5cRatalpha-Zearalanol multiple interactionsEXP 6480464[Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of KIF5C mRNACTDPMID:35163327
Kif5cRatantimycin A decreases expressionISOKIF5C (Homo sapiens)6480464Antimycin A results in decreased expression of KIF5C mRNACTDPMID:33512557
Kif5cRataristolochic acid A decreases expressionISOKIF5C (Homo sapiens)6480464aristolochic acid I results in decreased expression of KIF5C mRNACTDPMID:33212167
Kif5cRataristolochic acid A increases expressionISOKIF5C (Homo sapiens)6480464aristolochic acid I results in increased expression of KIF5C proteinCTDPMID:33212167
Kif5cRatazoxystrobin decreases expressionISOKIF5C (Homo sapiens)6480464azoxystrobin results in decreased expression of KIF5C mRNACTDPMID:33512557
Kif5cRatbenzatropine decreases expressionISOKIF5C (Homo sapiens)6480464Benztropine results in decreased expression of KIF5C proteinCTDPMID:34122009
Kif5cRatbenzo[a]pyrene increases expressionISOKif5c (Mus musculus)6480464Benzo(a)pyrene results in increased expression of KIF5C mRNACTDPMID:19770486
Kif5cRatbenzo[a]pyrene increases methylationISOKIF5C (Homo sapiens)6480464Benzo(a)pyrene results in increased methylation of KIF5C 3' UTR and Benzo(a)pyrene results in increased methylation of KIF5C exonCTDPMID:27901495

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Biological Process
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Cellular Component
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Original Reference(s)
Kif5cRataxon cytoplasm located_inIEAGO:00996411600115GO_REF:0000108GOCGO_REF:0000108
Kif5cRataxonal growth cone located_inIEAUniProtKB:P28738 and ensembl:ENSMUSP000000281021600115GO_REF:0000107EnsemblGO_REF:0000107
Kif5cRataxonal growth cone located_inISOKif5c (Mus musculus)1624291 PMID:24286867RGDPMID:24286867
Kif5cRatcell projection located_inIEAUniProtKB-KW:KW-09661600115GO_REF:0000043UniProtGO_REF:0000043
Kif5cRatciliary rootlet located_inISOKif5c (Mus musculus)1624291 PMID:16018997RGDPMID:16018997
Kif5cRatciliary rootlet located_inIEAUniProtKB:P28738 and ensembl:ENSMUSP000000281021600115GO_REF:0000107EnsemblGO_REF:0000107
Kif5cRatcytoplasm located_inISOKif5c (Mus musculus)1624291 PMID:16018997RGDPMID:16018997
Kif5cRatcytoplasm located_inIEAUniProtKB:P28738 and ensembl:ENSMUSP000000281021600115GO_REF:0000107EnsemblGO_REF:0000107
Kif5cRatcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Kif5cRatcytoskeleton located_inIEAUniProtKB-SubCell:SL-00901600115GO_REF:0000044UniProtGO_REF:0000044
Kif5cRatcytoskeleton located_inIEAUniProtKB-KW:KW-02061600115GO_REF:0000043UniProtGO_REF:0000043
Kif5cRatdendrite  IDA 6902916 RGD 
Kif5cRatdendrite located_inIEAUniProtKB-SubCell:SL-02831600115GO_REF:0000044UniProtGO_REF:0000044
Kif5cRatdendrite cytoplasm located_inIEAGO:00989641600115GO_REF:0000108GOCGO_REF:0000108
Kif5cRatdistal axon located_inISOKif5c (Mus musculus)1624291 PMID:24286867RGDPMID:24286867
Kif5cRatdistal axon located_inIEAUniProtKB:P28738 and ensembl:ENSMUSP000000281021600115GO_REF:0000107EnsemblGO_REF:0000107
Kif5cRatGABA-ergic synapse is_active_inIDA 10047142PMID:20152113SynGO 
Kif5cRatmicrotubule located_inIEAUniProtKB-KW:KW-04931600115GO_REF:0000043UniProtGO_REF:0000043
Kif5cRatneuron projection located_inIEAUniProtKB:P28738 and ensembl:ENSMUSP000000281021600115GO_REF:0000107EnsemblGO_REF:0000107
Kif5cRatneuron projection located_inISOKif5c (Mus musculus)1624291 PMID:16301330RGDPMID:16301330
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Molecular Function
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Original Reference(s)
Kif5cRatapolipoprotein receptor binding  IPILrp8 (Rattus norvegicus)2324636 RGD 
Kif5cRatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
Kif5cRatATP binding enablesIEAInterPro:IPR001752 and InterPro:IPR0198211600115GO_REF:0000002InterProGO_REF:0000002
Kif5cRatATP binding enablesIEAUniRule:UR0004010071600115GO_REF:0000104UniProtGO_REF:0000104
Kif5cRatATP hydrolysis activity  IDA 12792969 RGD 
Kif5cRatcytoskeletal motor activity enablesIEAUniRule:UR0004010071600115GO_REF:0000104UniProtGO_REF:0000104
Kif5cRathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
Kif5cRatmicrotubule binding  IDA 12792969 RGD 
Kif5cRatmicrotubule binding enablesIEAInterPro:IPR0017521600115GO_REF:0000002InterProGO_REF:0000002
Kif5cRatmicrotubule motor activity enablesIEAInterPro:IPR001752 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Kif5cRatnucleotide binding enablesIEAUniProtKB-KW:KW-05471600115GO_REF:0000043UniProtGO_REF:0000043
Kif5cRatnucleotide binding enablesIEAUniRule:UR0004010071600115GO_REF:0000104UniProtGO_REF:0000104
Kif5cRatprotein binding enablesISOKIF5C (Homo sapiens)1624291UniProtKB:O60296 more ...RGDPMID:15644324 more ...
Kif5cRatprotein binding enablesISOKif5c (Mus musculus)1624291PR:P33175 more ...RGDPMID:10602484 more ...
Kif5cRatprotein binding enablesISOKIF5C (Homo sapiens) and UniProtKB:O60282-21624291UniProtKB:Q6FHY5 and PMID:32296183RGDPMID:32296183
Kif5cRatprotein binding enablesIPIUniProtKB:Q8IXI28554369PMID:19135897IntAct 
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RGD Manual Annotations


  
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Original Reference(s)
Kif5cRatmitochondria transport pathway  ISOKIF5C (Homo sapiens)10402141 RGD 

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#
Reference Title
Reference Citation
1. Expression profiling of the cellular processes in uterine leiomyomas: omic approaches and IGF-2 association with leiomyosarcomas. Bae SM, etal., Cancer Res Treat. 2004 Feb;36(1):31-42. doi: 10.4143/crt.2004.36.1.31. Epub 2004 Feb 29.
2. Genetic modifiers and subtypes in schizophrenia: investigations of age at onset, severity, sex and family history. Bergen SE, etal., Schizophr Res. 2014 Apr;154(1-3):48-53. doi: 10.1016/j.schres.2014.01.030. Epub 2014 Feb 26.
3. Shank1 mRNA: dendritic transport by kinesin and translational control by the 5'untranslated region. Falley K, etal., Traffic. 2009 Jul;10(7):844-57. doi: 10.1111/j.1600-0854.2009.00912.x. Epub 2009 Apr 11.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Kinesin expression in the central nervous system of humans and transgenic hSOD1G93A mice with amyotrophic lateral sclerosis. Kuzma-Kozakiewicz M, etal., Neurodegener Dis. 2013;12(2):71-80. doi: 10.1159/000339529. Epub 2012 Sep 21.
7. Regulation of mitochondrial transport in neurons. Lin MY and Sheng ZH, Exp Cell Res. 2015 May 15;334(1):35-44. doi: 10.1016/j.yexcr.2015.01.004. Epub 2015 Jan 19.
8. Kinesin and ncd bind through a single head to microtubules and compete for a shared MT binding site. Lockhart A, etal., J Mol Biol. 1995 Jun 16;249(4):763-71.
9. Huntingtin mediates dendritic transport of beta-actin mRNA in rat neurons. Ma B, etal., Sci Rep. 2011;1:140. Epub 2011 Nov 3.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Familial Alzheimer's disease-associated presenilin-1 alters cerebellar activity and calcium homeostasis. Sepulveda-Falla D, etal., J Clin Invest. 2014 Apr;124(4):1552-67. doi: 10.1172/JCI66407. Epub 2014 Feb 24.
16. c-Jun NH2-terminal kinase (JNK)-interacting protein-3 (JIP3) regulates neuronal axon elongation in a kinesin- and JNK-dependent manner. Sun T, etal., J Biol Chem. 2013 May 17;288(20):14531-43. doi: 10.1074/jbc.M113.464453. Epub 2013 Apr 10.
17. Delivery of GABAARs to synapses is mediated by HAP1-KIF5 and disrupted by mutant huntingtin. Twelvetrees AE, etal., Neuron. 2010 Jan 14;65(1):53-65. doi: 10.1016/j.neuron.2009.12.007.
18. Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules. Verhey KJ, etal., J Cell Biol. 2001 Mar 5;152(5):959-70.
19. The mechanism of Ca2+ -dependent regulation of kinesin-mediated mitochondrial motility. Wang X and Schwarz TL, Cell. 2009 Jan 9;136(1):163-74. doi: 10.1016/j.cell.2008.11.046.
20. The RNA-binding protein MARTA2 regulates dendritic targeting of MAP2 mRNAs in rat neurons. Zivraj KH, etal., J Neurochem. 2013 Mar;124(5):670-84. doi: 10.1111/jnc.12079. Epub 2013 Jan 20.
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PMID:9405049   PMID:9428521   PMID:10964943   PMID:11319135   PMID:15644324   PMID:16018997   PMID:16301330   PMID:17887960   PMID:19608740   PMID:20032309   PMID:21700703   PMID:22871113  
PMID:24286867   PMID:24940781   PMID:26767417   PMID:27699600   PMID:28302907   PMID:29476059   PMID:31084716   PMID:34348158   PMID:36675068  



Kif5c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8354,441,266 - 54,591,630 (+)NCBIGRCr8
mRatBN7.2334,032,082 - 34,185,597 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl334,032,105 - 34,182,413 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx337,402,568 - 37,553,043 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0345,987,291 - 46,137,761 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0343,799,352 - 43,950,019 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0335,014,157 - 35,257,417 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl335,014,538 - 35,257,407 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0340,150,177 - 40,380,889 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4330,602,210 - 30,755,482 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1330,498,932 - 30,637,511 (+)NCBI
Celera332,217,717 - 32,366,850 (+)NCBICelera
Cytogenetic Map3q12NCBI
KIF5C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382148,875,227 - 149,026,759 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2148,875,227 - 149,026,759 (+)EnsemblGRCh38hg38GRCh38
GRCh372149,632,796 - 149,883,273 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362149,349,289 - 149,396,266 (+)NCBINCBI36Build 36hg18NCBI36
Build 362149,502,042 - 149,591,519 (+)NCBINCBI36Build 36hg18NCBI36
Celera2143,347,002 - 143,497,189 (+)NCBICelera
Cytogenetic Map2q23.1-q23.2NCBI
HuRef2141,692,099 - 141,781,519 (+)NCBIHuRef
HuRef2141,630,811 - 141,685,094 (+)NCBIHuRef
CHM1_12149,799,659 - 149,889,137 (+)NCBICHM1_1
CHM1_12149,638,662 - 149,692,791 (+)NCBICHM1_1
T2T-CHM13v2.02149,325,585 - 149,477,131 (+)NCBIT2T-CHM13v2.0
Kif5c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39249,509,298 - 49,664,790 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl249,509,310 - 49,664,790 (+)EnsemblGRCm39 Ensembl
GRCm38249,619,286 - 49,774,778 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl249,619,298 - 49,774,778 (+)EnsemblGRCm38mm10GRCm38
MGSCv37249,474,834 - 49,630,298 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36249,441,323 - 49,596,787 (+)NCBIMGSCv36mm8
Celera251,292,276 - 51,447,919 (+)NCBICelera
Cytogenetic Map2C1.1NCBI
cM Map228.68NCBI
Kif5c
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544014,754,639 - 14,854,406 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544014,754,931 - 14,854,090 (+)NCBIChiLan1.0ChiLan1.0
KIF5C
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21325,901,834 - 26,053,898 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B25,916,801 - 26,068,844 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B10,836,356 - 10,987,683 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B153,235,329 - 153,387,221 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B153,235,329 - 153,387,221 (+)Ensemblpanpan1.1panPan2
KIF5C
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11950,535,622 - 50,684,485 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1950,535,456 - 50,668,738 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1950,659,035 - 50,807,788 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01952,008,886 - 52,158,206 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1952,008,672 - 52,154,871 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11950,652,619 - 50,801,801 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01950,787,472 - 50,935,851 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01952,186,427 - 52,334,911 (+)NCBIUU_Cfam_GSD_1.0
Kif5c
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303113,186,109 - 113,337,599 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646928,280,095 - 28,431,695 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646928,282,921 - 28,431,638 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KIF5C
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl153,190,343 - 3,361,410 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1153,190,341 - 3,361,470 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2152,730,440 - 2,901,563 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KIF5C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11034,285,048 - 34,441,918 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1034,285,037 - 34,444,863 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040165,078,867 - 165,231,441 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kif5c
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248661,526,638 - 1,698,301 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248661,526,647 - 1,698,113 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Kif5c
1227 total Variants

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:49
Interacting mature miRNAs:51
Transcripts:ENSRNOT00000006341
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 50 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1298073Cm13Cardiac mass QTL 132.5heart mass (VT:0007028)heart wet weight (CMO:0000069)32501391138192233Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
631832Sach1Saccharin preference QTL 12.70.02consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)32749462144188411Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)32824968773249687Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2313093Bmd77Bone mineral density QTL 772.20.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)32749462150302886Rat
12879852Cm93Cardiac mass QTL 930.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)31831145447233430Rat

1 to 10 of 50 rows
D3Got22  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8354,514,719 - 54,514,855 (+)Marker Load Pipeline
mRatBN7.2334,105,497 - 34,105,633 (+)MAPPERmRatBN7.2
Rnor_6.0335,176,560 - 35,176,695NCBIRnor6.0
Rnor_5.0340,303,203 - 40,303,338UniSTSRnor5.0
RGSC_v3.4330,678,696 - 30,678,832RGDRGSC3.4
RGSC_v3.4330,678,697 - 30,678,832UniSTSRGSC3.4
RGSC_v3.1330,575,068 - 30,575,204RGD
Celera332,289,943 - 32,290,078UniSTS
Cytogenetic Map3q12UniSTS
RH142774  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2334,182,586 - 34,182,774 (+)MAPPERmRatBN7.2
Rnor_6.0335,254,407 - 35,254,594NCBIRnor6.0
Rnor_5.0340,381,063 - 40,381,250UniSTSRnor5.0
RGSC_v3.4330,755,656 - 30,755,844UniSTSRGSC3.4
Celera332,367,024 - 32,367,211UniSTS
RH 3.4 Map3411.51UniSTS
Cytogenetic Map3q12UniSTS
BE096005  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2334,168,985 - 34,169,159 (+)MAPPERmRatBN7.2
Rnor_6.0335,240,806 - 35,240,979NCBIRnor6.0
Rnor_5.0340,367,462 - 40,367,635UniSTSRnor5.0
RGSC_v3.4330,742,055 - 30,742,228UniSTSRGSC3.4
Celera332,353,423 - 32,353,596UniSTS
RH 3.4 Map3413.71UniSTS
Cytogenetic Map3q12UniSTS
PMC133732P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2334,106,821 - 34,107,282 (+)MAPPERmRatBN7.2
Rnor_6.0335,177,884 - 35,178,344NCBIRnor6.0
Rnor_5.0340,304,527 - 40,304,987UniSTSRnor5.0
RGSC_v3.4330,680,021 - 30,680,481UniSTSRGSC3.4
Celera332,291,267 - 32,291,727UniSTS
Cytogenetic Map3q12UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 49 113 88 87 56 25 56 6 213 95 93 45 60 31



Ensembl Acc Id: ENSRNOT00000006341   ⟹   ENSRNOP00000006341
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl334,032,105 - 34,182,413 (+)Ensembl
Rnor_6.0 Ensembl335,014,538 - 35,239,888 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000081744   ⟹   ENSRNOP00000071329
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl334,032,105 - 34,182,413 (+)Ensembl
Rnor_6.0 Ensembl335,175,313 - 35,257,407 (+)Ensembl
RefSeq Acc Id: NM_001107730   ⟹   NP_001101200
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8354,441,307 - 54,591,630 (+)NCBI
mRatBN7.2334,032,105 - 34,182,413 (+)NCBI
Rnor_6.0335,014,187 - 35,254,233 (+)NCBI
Rnor_5.0340,150,177 - 40,380,889 (+)NCBI
RGSC_v3.4330,602,210 - 30,755,482 (+)RGD
Celera332,217,717 - 32,366,850 (+)RGD
Sequence:
RefSeq Acc Id: XM_063283548   ⟹   XP_063139618
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8354,441,266 - 54,582,391 (+)NCBI
RefSeq Acc Id: XM_063283549   ⟹   XP_063139619
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8354,441,266 - 54,591,138 (+)NCBI
Protein RefSeqs NP_001101200 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139618 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139619 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM00464 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000006341
  ENSRNOP00000006341.8
GenBank Protein P56536 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001101200   ⟸   NM_001107730
- UniProtKB: P56536 (UniProtKB/Swiss-Prot),   G3V6L4 (UniProtKB/Swiss-Prot),   A0A0G2K070 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006341   ⟸   ENSRNOT00000006341
Ensembl Acc Id: ENSRNOP00000071329   ⟸   ENSRNOT00000081744
RefSeq Acc Id: XP_063139619   ⟸   XM_063283549
- Peptide Label: isoform X1
- UniProtKB: P56536 (UniProtKB/Swiss-Prot),   G3V6L4 (UniProtKB/Swiss-Prot),   A0A0G2K070 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139618   ⟸   XM_063283548
- Peptide Label: isoform X1
- UniProtKB: P56536 (UniProtKB/Swiss-Prot),   G3V6L4 (UniProtKB/Swiss-Prot),   A0A0G2K070 (UniProtKB/TrEMBL)
Kinesin motor

Name Modeler Protein Id AA Range Protein Structure
AF-P56536-F1-model_v2 AlphaFold P56536 1-239 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13692069
Promoter ID:EPDNEW_R2594
Type:single initiation site
Name:Kif5c_1
Description:kinesin family member 5C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0335,014,515 - 35,014,575EPDNEW


1 to 27 of 27 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-49761 BioCyc
Ensembl Genes ENSRNOG00000004680 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000006341 ENTREZGENE
  ENSRNOT00000006341.8 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.850.10 UniProtKB/Swiss-Prot
  6.10.250.1590 UniProtKB/Swiss-Prot
InterPro Kinesin-like_fam UniProtKB/Swiss-Prot
  Kinesin_motor_CS UniProtKB/Swiss-Prot
  Kinesin_motor_dom UniProtKB/Swiss-Prot
  Kinesin_motor_dom_sf UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
KEGG Report rno:311024 UniProtKB/Swiss-Prot
NCBI Gene 311024 ENTREZGENE
PANTHER CENTROMERE PROTEIN E UniProtKB/Swiss-Prot
  KINESIN HEAVY CHAIN ISOFORM 5C UniProtKB/Swiss-Prot
Pfam Kinesin UniProtKB/Swiss-Prot
PhenoGen Kif5c PhenoGen
PRINTS KINESINHEAVY UniProtKB/Swiss-Prot
PROSITE KINESIN_MOTOR_1 UniProtKB/Swiss-Prot
  KINESIN_MOTOR_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000004680 RatGTEx
SMART KISc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A0A0G2K070 ENTREZGENE, UniProtKB/TrEMBL
  G3V6L4 ENTREZGENE
  KIF5C_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary G3V6L4 UniProtKB/Swiss-Prot
1 to 27 of 27 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Kif5c  kinesin family member 5C   Kif5c_predicted  kinesin family member 5C (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Kif5c_predicted  kinesin family member 5C (predicted)      Symbol and Name status set to approved 70820 APPROVED