Ptk7 (protein tyrosine kinase 7) - Rat Genome Database

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Pathways
Gene: Ptk7 (protein tyrosine kinase 7) Rattus norvegicus
Analyze
Symbol: Ptk7
Name: protein tyrosine kinase 7
RGD ID: 1310472
Description: Predicted to enable ATP binding activity. Predicted to be involved in several processes, including cellular response to retinoic acid; positive regulation of canonical Wnt signaling pathway; and positive regulation of neuron projection development. Predicted to act upstream of or within several processes, including cochlea morphogenesis; heart development; and morphogenesis of an epithelium. Predicted to be located in cell-cell junction and plasma membrane. Orthologous to human PTK7 (protein tyrosine kinase 7 (inactive)); PARTICIPATES IN Wnt signaling, the planar cell polarity pathway; INTERACTS WITH 1,3-dinitrobenzene; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: inactive tyrosine-protein kinase 7; LOC301242; PTK7 protein tyrosine kinase 7; tyrosine-protein kinase-like 7
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2914,352,155 - 14,418,473 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl914,351,202 - 14,418,494 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx922,936,018 - 23,002,174 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0927,998,899 - 28,065,207 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0926,299,393 - 26,365,553 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0916,662,588 - 16,729,888 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl916,702,460 - 16,729,030 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0915,569,249 - 15,634,907 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.199,683,466 - 9,739,282 (+)NCBI
Celera912,100,043 - 12,166,064 (+)NCBICelera
Cytogenetic Map9q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Planar cell polarity signaling in vertebrates. Jones C and Chen P, Bioessays. 2007 Feb;29(2):120-32.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15019986   PMID:15229603   PMID:15802564   PMID:17910947   PMID:20215345   PMID:20643356   PMID:20704721   PMID:20837484   PMID:21132015   PMID:21423176   PMID:25807483  


Genomics

Comparative Map Data
Ptk7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2914,352,155 - 14,418,473 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl914,351,202 - 14,418,494 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx922,936,018 - 23,002,174 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0927,998,899 - 28,065,207 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0926,299,393 - 26,365,553 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0916,662,588 - 16,729,888 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl916,702,460 - 16,729,030 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0915,569,249 - 15,634,907 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.199,683,466 - 9,739,282 (+)NCBI
Celera912,100,043 - 12,166,064 (+)NCBICelera
Cytogenetic Map9q12NCBI
PTK7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38643,076,314 - 43,161,715 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl643,076,307 - 43,161,719 (+)EnsemblGRCh38hg38GRCh38
GRCh37643,044,052 - 43,129,453 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36643,152,007 - 43,237,435 (+)NCBINCBI36Build 36hg18NCBI36
Build 34643,152,006 - 43,237,435NCBI
Celera644,596,273 - 44,681,681 (+)NCBICelera
Cytogenetic Map6p21.1NCBI
HuRef642,760,999 - 42,846,114 (+)NCBIHuRef
CHM1_1643,046,463 - 43,132,349 (+)NCBICHM1_1
T2T-CHM13v2.0642,905,060 - 42,990,493 (+)NCBIT2T-CHM13v2.0
Ptk7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391746,875,377 - 46,940,975 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1746,875,397 - 46,940,430 (-)EnsemblGRCm39 Ensembl
GRCm381746,564,451 - 46,630,049 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1746,564,471 - 46,629,504 (-)EnsemblGRCm38mm10GRCm38
MGSCv371746,701,400 - 46,766,453 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361746,027,640 - 46,092,625 (-)NCBIMGSCv36mm8
Celera1750,000,320 - 50,065,330 (-)NCBICelera
Cytogenetic Map17CNCBI
cM Map1722.9NCBI
Ptk7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554379,037,661 - 9,094,287 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554379,037,933 - 9,094,237 (+)NCBIChiLan1.0ChiLan1.0
PTK7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1653,446,156 - 53,532,268 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0642,668,077 - 42,753,547 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1643,962,566 - 44,047,346 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl643,962,560 - 44,051,146 (+)Ensemblpanpan1.1panPan2
PTK7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11211,593,017 - 11,657,149 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1211,593,043 - 11,656,320 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1211,620,045 - 11,684,140 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01212,074,382 - 12,139,509 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1212,074,376 - 12,139,507 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11211,603,020 - 11,667,064 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01211,687,299 - 11,751,491 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01211,781,164 - 11,846,279 (+)NCBIUU_Cfam_GSD_1.0
Ptk7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494647,093,213 - 47,162,366 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647616,798,686 - 16,866,896 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647616,797,836 - 16,866,989 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTK7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl738,135,655 - 38,205,655 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1738,135,675 - 38,205,662 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2743,636,042 - 43,706,031 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTK7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11729,001,797 - 29,083,767 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1729,001,805 - 29,083,700 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604443,139,028 - 43,220,861 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptk7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475416,386,296 - 16,440,681 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475416,386,437 - 16,441,341 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ptk7
354 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:68
Count of miRNA genes:61
Interacting mature miRNAs:68
Transcripts:ENSRNOT00000061432
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70226Eae4Experimental allergic encephalomyelitis QTL 4nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)9125661317Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
7411592Foco8Food consumption QTL 87.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9137999212Rat
9589158Gluco65Glucose level QTL 656.820.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)9137999212Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
1298088Edpm11Estrogen-dependent pituitary mass QTL 112.5pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)9143718459Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
61450Ciaa3CIA Autoantibody QTL 36.5blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)9795472022071169Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
1600365Mcs20Mammary carcinoma susceptibility QTL 203mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)91353377042791750Rat

Markers in Region
RH127795  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2914,350,702 - 14,350,904 (+)MAPPERmRatBN7.2
Rnor_6.0916,661,091 - 16,661,292NCBIRnor6.0
Rnor_5.0915,567,706 - 15,567,907UniSTSRnor5.0
RGSC_v3.4910,002,362 - 10,002,563UniSTSRGSC3.4
Celera912,098,500 - 12,098,701UniSTS
RH 3.4 Map958.3UniSTS
Cytogenetic Map9q12UniSTS
RH132300  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2914,371,237 - 14,371,431 (+)MAPPERmRatBN7.2
Rnor_6.0916,681,627 - 16,681,820NCBIRnor6.0
Rnor_5.0915,588,242 - 15,588,435UniSTSRnor5.0
RGSC_v3.499,981,536 - 9,981,729UniSTSRGSC3.4
Celera912,119,008 - 12,119,201UniSTS
RH 3.4 Map955.0UniSTS
Cytogenetic Map9q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 26 12 6 14 6 60 26 35 11
Low 3 17 40 30 5 30 6 9 14 9 6 6
Below cutoff 5 5 5 2 2 2

Sequence


RefSeq Acc Id: ENSRNOT00000061432   ⟹   ENSRNOP00000058151
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl914,391,806 - 14,418,494 (+)Ensembl
Rnor_6.0 Ensembl916,702,460 - 16,729,030 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108486   ⟹   ENSRNOP00000094298
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl914,352,254 - 14,418,469 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000113952   ⟹   ENSRNOP00000097123
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl914,351,202 - 14,392,416 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000118183   ⟹   ENSRNOP00000094722
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl914,352,800 - 14,418,469 (+)Ensembl
RefSeq Acc Id: NM_001395741   ⟹   NP_001382670
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2914,352,155 - 14,418,473 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001382670 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM18829 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000058151.5
  ENSRNOP00000094298
  ENSRNOP00000094298.1
  ENSRNOP00000094722.1
  ENSRNOP00000097123.1
RefSeq Acc Id: ENSRNOP00000058151   ⟸   ENSRNOT00000061432
RefSeq Acc Id: ENSRNOP00000094722   ⟸   ENSRNOT00000118183
RefSeq Acc Id: ENSRNOP00000097123   ⟸   ENSRNOT00000113952
RefSeq Acc Id: ENSRNOP00000094298   ⟸   ENSRNOT00000108486
RefSeq Acc Id: NP_001382670   ⟸   NM_001395741
- Peptide Label: precursor
- UniProtKB: A0A8I6AKN3 (UniProtKB/TrEMBL),   A0A8I6ALM9 (UniProtKB/TrEMBL)
Protein Domains
Ig-like   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZHG3-F1-model_v2 AlphaFold D3ZHG3 1-778 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310472 AgrOrtholog
BioCyc Gene G2FUF-28233 BioCyc
Ensembl Genes ENSRNOG00000039976 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000061432.5 UniProtKB/TrEMBL
  ENSRNOT00000108486 ENTREZGENE
  ENSRNOT00000108486.1 UniProtKB/TrEMBL
  ENSRNOT00000113952.1 UniProtKB/TrEMBL
  ENSRNOT00000118183.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_I-set UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:301242 UniProtKB/TrEMBL
NCBI Gene 301242 ENTREZGENE
PANTHER CONTACTIN 5 UniProtKB/TrEMBL
  INACTIVE TYROSINE-PROTEIN KINASE 7 UniProtKB/TrEMBL
  LP22668P UniProtKB/TrEMBL
  TITIN UniProtKB/TrEMBL
Pfam I-set UniProtKB/TrEMBL
  Ig_3 UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
PharmGKB PTK7 RGD
PhenoGen Ptk7 PhenoGen
PRINTS TYRKINASE UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
RatGTEx ENSRNOG00000039976 RatGTEx
SMART IGc2 UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A8I6AKN3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ALM9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GLX5_RAT UniProtKB/TrEMBL
  D3ZHG3_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-03-26 Ptk7  protein tyrosine kinase 7  Ptk7  PTK7 protein tyrosine kinase 7  Name changed 629549 APPROVED
2008-04-30 Ptk7  PTK7 protein tyrosine kinase 7   Ptk7_predicted  PTK7 protein tyrosine kinase 7 (predicted)  'predicted' is removed 2292626 APPROVED
2006-08-22 Ptk7_predicted  PTK7 protein tyrosine kinase 7 (predicted)  Srf_predicted  serum response factor (predicted)  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2005-01-12 Srf_predicted  serum response factor (predicted)      Symbol and Name status set to approved 70820 APPROVED