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G |
G6pc1 |
glucose-6-phosphatase catalytic subunit 1 |
multiple interactions increases expression |
ISO |
dihydroouabain promotes the reaction [RORC protein binds to G6PC1 promoter] dihydroouabain results in increased expression of G6PC1 mRNA |
CTD |
PMID:29981919 |
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NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
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G |
Il17a |
interleukin 17A |
multiple interactions |
ISO |
dihydroouabain results in increased expression of and results in increased secretion of IL17A protein |
CTD |
PMID:29981919 |
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NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
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G |
Il17f |
interleukin 17F |
multiple interactions |
ISO |
dihydroouabain results in increased expression of and results in increased secretion of IL17F protein |
CTD |
PMID:29981919 |
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NCBI chr 9:23,190,094...23,201,482
Ensembl chr 9:23,190,100...23,201,482
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G |
Npas2 |
neuronal PAS domain protein 2 |
increases expression multiple interactions |
ISO |
dihydroouabain results in increased expression of NPAS2 mRNA dihydroouabain promotes the reaction [RORC protein binds to NPAS2 promoter] |
CTD |
PMID:29981919 |
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NCBI chr 9:41,463,361...41,642,322
Ensembl chr 9:41,463,830...41,642,320
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G |
Rorc |
RAR-related orphan receptor C |
multiple interactions increases expression |
ISO |
dihydroouabain promotes the reaction [RORC protein binds to G6PC1 promoter]; dihydroouabain promotes the reaction [RORC protein binds to NPAS2 promoter]; RORC protein promotes the reaction [dihydroouabain results in increased expression of RORC mRNA] |
CTD |
PMID:29981919 |
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NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
hellebrigenin results in decreased phosphorylation of and results in decreased expression of AKT1 protein |
CTD |
PMID:24954031 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Atm |
ATM serine/threonine kinase |
increases phosphorylation |
ISO |
hellebrigenin results in increased phosphorylation of ATM protein |
CTD |
PMID:24954031 |
|
NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
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G |
Bax |
BCL2 associated X, apoptosis regulator |
affects localization |
ISO |
hellebrigenin affects the localization of BAX protein |
CTD |
PMID:24954031 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Ccnb1 |
cyclin B1 |
increases expression |
ISO |
hellebrigenin results in increased expression of CCNB1 protein |
CTD |
PMID:24954031 |
|
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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G |
Cdc25c |
cell division cycle 25C |
decreases phosphorylation |
ISO |
hellebrigenin results in decreased phosphorylation of CDC25C protein |
CTD |
PMID:24954031 |
|
NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
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G |
Cdk1 |
cyclin-dependent kinase 1 |
increases phosphorylation |
ISO |
hellebrigenin results in increased phosphorylation of CDK1 protein |
CTD |
PMID:24954031 |
|
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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G |
Chek2 |
checkpoint kinase 2 |
increases phosphorylation |
ISO |
hellebrigenin results in increased phosphorylation of CHEK2 protein |
CTD |
PMID:24954031 |
|
NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases activity |
ISO |
hellebrigenin results in increased activity of PARP1 protein |
CTD |
PMID:24954031 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Rorc |
RAR-related orphan receptor C |
increases expression |
ISO |
helveticoside results in increased expression of RORC mRNA |
CTD |
PMID:29981919 |
|
NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907
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G |
A2m |
alpha-2-macroglobulin |
affects expression |
ISO |
Ouabain affects the expression of A2M protein |
CTD |
PMID:17268060 |
|
NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions increases expression |
ISO |
2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Ouabain results in increased expression of ABCB1 protein]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Ouabain results in increased expression of ABCB1 mRNA]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Ouabain results in increased expression of ABCB1 protein]; [Ouabain results in increased expression of ABCB1] which results in decreased susceptibility to Doxorubicin; KN 93 inhibits the reaction [Ouabain results in increased expression of ABCB1 protein] Ouabain results in increased expression of ABCB1 mRNA; Ouabain results in increased expression of ABCB1 protein |
CTD |
PMID:19647009 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Acaa2 |
acetyl-CoA acyltransferase 2 |
affects expression |
ISO |
Ouabain affects the expression of ACAA2 protein |
CTD |
PMID:17268060 |
|
NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249
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G |
Ace |
angiotensin I converting enzyme |
affects expression |
EXP |
Ouabain affects the expression of ACE mRNA; Ouabain affects the expression of ACE protein |
CTD |
PMID:16565308 |
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NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
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G |
Acta2 |
actin alpha 2, smooth muscle |
affects expression |
ISO |
Ouabain affects the expression of ACTA2 protein |
CTD |
PMID:17268060 |
|
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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G |
Adh1c |
alcohol dehydrogenase 1C (class I), gamma polypeptide |
affects expression |
ISO |
Ouabain affects the expression of ADH1C protein |
CTD |
PMID:17268060 |
|
NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892
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G |
Agt |
angiotensinogen |
affects expression increases expression |
EXP |
Ouabain affects the expression of AGT protein Ouabain results in increased expression of AGT protein |
CTD |
PMID:11768735 PMID:16565308 |
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NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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G |
Agtr1a |
angiotensin II receptor, type 1a |
decreases expression affects expression |
EXP |
Ouabain results in decreased expression of AGTR1A protein Ouabain affects the expression of AGTR1A mRNA |
CTD |
PMID:16565308 |
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NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
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G |
Aifm1 |
apoptosis inducing factor, mitochondria associated 1 |
increases expression |
ISO |
Ouabain results in increased expression of AIFM1 protein |
CTD |
PMID:31436044 |
|
NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
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G |
Anxa1 |
annexin A1 |
affects expression |
ISO |
Ouabain affects the expression of ANXA1 protein |
CTD |
PMID:17268060 |
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NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
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G |
Anxa2 |
annexin A2 |
affects expression |
ISO |
Ouabain affects the expression of ANXA2 protein |
CTD |
PMID:17268060 |
|
NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658
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G |
Apaf1 |
apoptotic peptidase activating factor 1 |
increases expression |
ISO |
Ouabain results in increased expression of APAF1 protein |
CTD |
PMID:31436044 |
|
NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
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G |
Araf |
A-Raf proto-oncogene, serine/threonine kinase |
decreases expression |
ISO |
Ouabain results in decreased expression of ARAF mRNA |
CTD |
PMID:16412265 |
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NCBI chr X:1,227,392...1,292,356
Ensembl chr X:1,227,392...1,239,073
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G |
Arih1 |
ariadne RBR E3 ubiquitin protein ligase 1 |
decreases expression |
ISO |
Ouabain results in decreased expression of ARIH1 mRNA |
CTD |
PMID:16412265 |
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NCBI chr 8:59,777,378...59,879,762
Ensembl chr 8:59,777,379...59,880,245
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G |
Arpc5 |
actin related protein 2/3 complex, subunit 5 |
affects expression |
ISO |
Ouabain affects the expression of ARPC5 protein |
CTD |
PMID:17268060 |
|
NCBI chr13:64,904,504...64,913,413
Ensembl chr13:64,887,136...64,913,410
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G |
Arrb1 |
arrestin, beta 1 |
increases expression |
ISO |
Ouabain results in increased expression of ARRB1 mRNA |
CTD |
PMID:16412265 |
|
NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061
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G |
Asah1 |
N-acylsphingosine amidohydrolase 1 |
affects expression |
ISO |
Ouabain affects the expression of ASAH1 protein |
CTD |
PMID:17268060 |
|
NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233
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G |
Atf6b |
activating transcription factor 6 beta |
increases expression |
ISO |
Ouabain results in increased expression of ATF6B protein |
CTD |
PMID:31436044 |
|
NCBI chr20:4,090,921...4,098,920
Ensembl chr20:4,090,921...4,098,894
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G |
Atm |
ATM serine/threonine kinase |
increases phosphorylation |
ISO |
Ouabain results in increased phosphorylation of ATM protein |
CTD |
PMID:31436044 |
|
NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
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G |
Atp12a |
ATPase H+/K+ transporting non-gastric alpha2 subunit |
multiple interactions |
ISO |
Ouabain inhibits the reaction [[ATP12A protein co-treated with ATP4B protein] results in increased uptake of Rubidium] |
CTD |
PMID:8853415 |
|
NCBI chr15:30,443,571...30,468,229
Ensembl chr15:30,443,571...30,468,229
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G |
Atp1a1 |
ATPase Na+/K+ transporting subunit alpha 1 |
multiple interactions affects binding increases expression affects expression |
ISO EXP |
Lithium inhibits the reaction [Ouabain results in increased expression of ATP1A1 mRNA]; Lithium inhibits the reaction [Ouabain results in increased expression of ATP1A1 protein] Ouabain binds to ATP1A1 protein Ouabain results in increased expression of ATP1A1 mRNA; Ouabain results in increased expression of ATP1A1 protein Ouabain affects the expression of ATP1A1 protein |
CTD |
PMID:11768735 PMID:11834625 PMID:12479229 PMID:16716361 PMID:19995221 |
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NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837
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G |
Atp1a2 |
ATPase Na+/K+ transporting subunit alpha 2 |
multiple interactions affects binding increases expression affects response to substance decreases activity affects expression decreases expression |
ISO EXP |
Lithium inhibits the reaction [Ouabain results in increased expression of ATP1A2 mRNA] Ouabain binds to ATP1A2 protein ATP1A2 protein affects the susceptibility to Ouabain Ouabain binds to and results in decreased activity of ATP1A2 protein Ouabain results in decreased activity of ATP1A2 protein N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in decreased expression of ATP1A2 mRNA] Ouabain affects the expression of ATP1A2 protein Ouabain results in increased expression of ATP1A2 protein |
CTD |
PMID:11834625 PMID:12479229 PMID:15458945 PMID:16166162 PMID:16716361 PMID:18487447 PMID:19687166 PMID:19897708 PMID:19995221 More...
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NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544
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G |
Atp1a3 |
ATPase Na+/K+ transporting subunit alpha 3 |
increases expression affects binding multiple interactions affects expression decreases expression |
ISO EXP |
Ouabain results in increased expression of ATP1A3 mRNA; Ouabain results in increased expression of ATP1A3 protein ATP1A3 protein binds to Ouabain; Ouabain binds to ATP1A3 protein N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in decreased expression of ATP1A3 mRNA] Ouabain affects the expression of ATP1A3 protein Potassium Chloride inhibits the reaction [ATP1A3 protein binds to Ouabain] |
CTD |
PMID:11204457 PMID:12479229 PMID:15276875 PMID:19687166 PMID:19995221 PMID:24631656 More...
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NCBI chr 1:80,572,790...80,601,936
Ensembl chr 1:80,572,796...80,601,918
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G |
Atp1b1 |
ATPase Na+/K+ transporting subunit beta 1 |
multiple interactions increases expression |
EXP |
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Ouabain results in increased expression of ATP1B1 mRNA]; Calcium affects the reaction [Ouabain results in increased expression of ATP1B1 mRNA]; W 7 inhibits the reaction [Ouabain results in increased expression of ATP1B1 mRNA] |
CTD |
PMID:11204457 |
|
NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459
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G |
Atp4b |
ATPase H+/K+ transporting subunit beta |
multiple interactions |
ISO |
Ouabain inhibits the reaction [[ATP12A protein co-treated with ATP4B protein] results in increased uptake of Rubidium] |
CTD |
PMID:8853415 |
|
NCBI chr16:76,144,150...76,153,063
Ensembl chr16:76,144,150...76,153,063
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G |
Atp5f1a |
ATP synthase F1 subunit alpha |
affects expression |
ISO |
Ouabain affects the expression of ATP5F1A protein |
CTD |
PMID:17268060 |
|
NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794
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G |
Atr |
ATR serine/threonine kinase |
decreases phosphorylation |
ISO |
Ouabain results in decreased phosphorylation of ATR protein |
CTD |
PMID:31436044 |
|
NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136
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G |
Bahd1 |
bromo adjacent homology domain containing 1 |
decreases expression |
ISO |
Ouabain results in decreased expression of BAHD1 mRNA |
CTD |
PMID:16412265 |
|
NCBI chr 3:105,891,207...105,914,414
Ensembl chr 3:105,892,478...105,914,410
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G |
Bax |
BCL2 associated X, apoptosis regulator |
affects localization multiple interactions increases expression |
ISO |
Ouabain affects the localization of BAX protein Ouabain inhibits the reaction [HSPD1 protein binds to BAX protein] Ouabain results in increased expression of BAX protein |
CTD |
PMID:17096883 PMID:18247327 PMID:31436044 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
Ouabain results in decreased expression of BCL2 protein |
CTD |
PMID:31436044 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2l1 |
Bcl2-like 1 |
decreases expression |
ISO |
Ouabain results in decreased expression of BCL2L1 protein |
CTD |
PMID:31436044 |
|
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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G |
Bdnf |
brain-derived neurotrophic factor |
multiple interactions decreases expression |
EXP |
Lithium inhibits the reaction [Ouabain results in decreased expression of BDNF protein] |
CTD |
PMID:19954800 |
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NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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G |
Brca1 |
BRCA1, DNA repair associated |
decreases expression |
ISO |
Ouabain results in decreased expression of BRCA1 protein |
CTD |
PMID:31436044 |
|
NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
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G |
Calb1 |
calbindin 1 |
decreases expression |
EXP |
Ouabain results in decreased expression of CALB1 protein |
CTD |
PMID:20105455 |
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NCBI chr 5:29,375,624...29,402,532
Ensembl chr 5:29,375,642...29,402,431
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G |
Calml5 |
calmodulin-like 5 |
affects expression |
ISO |
Ouabain affects the expression of CALML5 protein |
CTD |
PMID:17268060 |
|
NCBI chr17:66,394,433...66,395,352
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G |
Camk2b |
calcium/calmodulin-dependent protein kinase II beta |
increases expression |
ISO |
Ouabain results in increased expression of CAMK2B protein |
CTD |
PMID:31436044 |
|
NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994
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G |
Canx |
calnexin |
increases expression |
ISO |
Ouabain results in increased expression of CANX protein |
CTD |
PMID:18247327 |
|
NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821
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G |
Casp3 |
caspase 3 |
increases expression increases activity multiple interactions |
ISO EXP |
Ouabain results in increased expression of CASP3 protein Ouabain results in increased activity of CASP3 protein Ouabain results in increased activity of and results in increased cleavage of CASP3 protein |
CTD |
PMID:11435898 PMID:17096883 PMID:18247327 PMID:20435043 PMID:31436044 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp4 |
caspase 4 |
increases expression |
ISO |
Ouabain results in increased expression of CASP4 protein |
CTD |
PMID:31436044 |
|
NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
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G |
Casp8 |
caspase 8 |
multiple interactions |
ISO |
Ouabain results in increased expression of and results in increased activity of CASP8 protein |
CTD |
PMID:31436044 |
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
multiple interactions |
ISO |
Ouabain results in increased expression of and results in increased activity of CASP9 protein |
CTD |
PMID:31436044 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
multiple interactions decreases activity |
EXP |
Lithium inhibits the reaction [Ouabain results in decreased activity of CAT protein]; Valproic Acid inhibits the reaction [Ouabain results in decreased activity of CAT protein] |
CTD |
PMID:20627318 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Cav1 |
caveolin 1 |
decreases expression |
ISO |
Ouabain results in decreased expression of CAV1 mRNA |
CTD |
PMID:28795476 |
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NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
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G |
Ccdc14 |
coiled-coil domain containing 14 |
decreases expression |
ISO |
Ouabain results in decreased expression of CCDC14 mRNA |
CTD |
PMID:16412265 |
|
NCBI chr11:66,052,063...66,087,915
Ensembl chr11:66,052,620...66,087,956
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions increases expression |
EXP |
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Ouabain results in increased expression of CCL2 mRNA]; Amiloride inhibits the reaction [Ouabain results in increased expression of CCL2 protein]; Sodium deficiency inhibits the reaction [Ouabain results in increased expression of CCL2 mRNA]; Sodium deficiency inhibits the reaction [Ouabain results in increased expression of CCL2 protein] Ouabain results in increased expression of CCL2 mRNA; Ouabain results in increased expression of CCL2 protein |
CTD |
PMID:11340305 |
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccna1 |
cyclin A1 |
decreases expression |
ISO |
Ouabain results in decreased expression of CCNA1 mRNA |
CTD |
PMID:20460749 |
|
NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157
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G |
Ccna2 |
cyclin A2 |
decreases expression |
ISO |
Ouabain results in decreased expression of CCNA2 mRNA |
CTD |
PMID:21215801 |
|
NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
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G |
Ccnd1 |
cyclin D1 |
decreases expression |
ISO |
Ouabain results in decreased expression of CCND1 mRNA |
CTD |
PMID:28795476 |
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Cdh1 |
cadherin 1 |
decreases expression increases expression |
ISO |
Ouabain results in decreased expression of CDH1 protein Ouabain results in increased expression of CDH1 mRNA |
CTD |
PMID:28795476 |
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NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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G |
Cdh2 |
cadherin 2 |
decreases expression |
ISO |
Ouabain results in decreased expression of CDH2 mRNA; Ouabain results in decreased expression of CDH2 protein |
CTD |
PMID:28795476 |
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NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
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G |
Cdk2 |
cyclin dependent kinase 2 |
decreases expression |
ISO |
Ouabain results in decreased expression of CDK2 mRNA; Ouabain results in decreased expression of CDK2 protein |
CTD |
PMID:20460749 PMID:21215801 PMID:31436044 |
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NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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G |
Cdk6 |
cyclin-dependent kinase 6 |
decreases expression |
ISO |
Ouabain results in decreased expression of CDK6 protein |
CTD |
PMID:31436044 |
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NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
decreases expression increases expression |
ISO |
Ouabain results in decreased expression of CDKN1A mRNA; Ouabain results in decreased expression of CDKN1A protein Ouabain results in increased expression of CDKN1A mRNA; Ouabain results in increased expression of CDKN1A protein |
CTD |
PMID:20460749 PMID:21215801 PMID:28795476 PMID:31436044 |
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Ckb |
creatine kinase B |
decreases activity |
EXP |
Ouabain results in decreased activity of CKB protein |
CTD |
PMID:19911114 |
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NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315
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G |
Cldn1 |
claudin 1 |
decreases expression |
ISO |
Ouabain results in decreased expression of CLDN1 protein |
CTD |
PMID:18247327 |
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NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724
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G |
Cnpy2 |
canopy FGF signaling regulator 2 |
affects expression |
ISO |
Ouabain affects the expression of CNPY2 protein |
CTD |
PMID:17268060 |
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NCBI chr 7:748,877...754,352
Ensembl chr 7:749,008...755,519
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G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions increases expression |
EXP |
MIR29B1 mRNA inhibits the reaction [Ouabain results in increased expression of COL1A1 mRNA] |
CTD |
PMID:26702050 |
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NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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G |
Cs |
citrate synthase |
decreases activity |
EXP |
Ouabain results in decreased activity of CS protein |
CTD |
PMID:20372980 |
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NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421
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G |
Cyc1 |
cytochrome c-1 |
multiple interactions |
ISO |
Ouabain results in decreased expression of and affects the localization of CYC1 protein |
CTD |
PMID:18247327 |
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NCBI chr 7:108,067,106...108,069,483
Ensembl chr 7:108,067,115...108,069,479
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases expression |
ISO |
Ouabain results in increased expression of DDIT3 protein |
CTD |
PMID:31436044 |
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NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Ddost |
dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit |
decreases expression |
ISO |
Ouabain results in decreased expression of DDOST mRNA |
CTD |
PMID:16412265 |
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NCBI chr 5:150,522,297...150,529,413
Ensembl chr 5:150,522,242...150,529,413
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G |
Dnaja3 |
DnaJ heat shock protein family (Hsp40) member A3 |
increases expression |
ISO |
Ouabain results in increased expression of DNAJA3 mRNA |
CTD |
PMID:28795476 |
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NCBI chr10:10,854,732...10,880,171
Ensembl chr10:10,854,732...10,880,161
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G |
Drd1 |
dopamine receptor D1 |
multiple interactions decreases expression |
ISO EXP |
Ouabain results in decreased expression of and results in increased phosphorylation of DRD1 protein Ouabain results in decreased expression of DRD1 mRNA Ouabain results in increased phosphorylation of and results in decreased expression of DRD1 protein |
CTD |
PMID:19626329 PMID:20132239 |
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NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
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G |
Dsg1 |
desmoglein 1 |
affects expression |
ISO |
Ouabain affects the expression of DSG1 protein |
CTD |
PMID:17268060 |
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NCBI chr18:11,674,687...11,705,383
Ensembl chr18:11,674,402...11,703,443
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G |
Dut |
deoxyuridine triphosphatase |
affects expression |
ISO |
Ouabain affects the expression of DUT protein |
CTD |
PMID:17268060 |
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NCBI chr 3:112,498,864...112,509,994
Ensembl chr 3:112,498,982...112,510,771
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G |
Ece1 |
endothelin converting enzyme 1 |
increases expression |
ISO |
Ouabain results in increased expression of ECE1 protein |
CTD |
PMID:18247327 |
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NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371
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G |
Echs1 |
enoyl-CoA hydratase, short chain 1 |
affects expression |
ISO |
Ouabain affects the expression of ECHS1 protein |
CTD |
PMID:17268060 |
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NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884
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G |
Edn1 |
endothelin 1 |
increases expression decreases expression |
EXP ISO |
Ouabain results in increased expression of EDN1 mRNA Ouabain results in decreased expression of EDN1 mRNA |
CTD |
PMID:15477225 PMID:28795476 |
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NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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G |
Ednra |
endothelin receptor type A |
increases expression |
EXP |
Ouabain results in increased expression of EDNRA mRNA; Ouabain results in increased expression of EDNRA protein |
CTD |
PMID:15477225 PMID:16982439 |
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NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049
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G |
Egfr |
epidermal growth factor receptor |
decreases phosphorylation |
ISO |
Ouabain results in decreased phosphorylation of EGFR protein |
CTD |
PMID:28795476 |
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NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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G |
Eif2a |
eukaryotic translation initiation factor 2A |
increases expression |
ISO |
Ouabain results in increased expression of EIF2A protein |
CTD |
PMID:31436044 |
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NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068
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G |
Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
multiple interactions |
ISO |
Ouabain results in increased expression of and results in increased phosphorylation of EIF2AK3 protein |
CTD |
PMID:31436044 |
|
NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
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G |
Eif3k |
eukaryotic translation initiation factor 3, subunit K |
affects expression |
ISO |
Ouabain affects the expression of EIF3K protein |
CTD |
PMID:17268060 |
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NCBI chr 1:84,260,127...84,270,051
Ensembl chr 1:84,259,673...84,270,302
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G |
Endog |
endonuclease G |
increases expression |
ISO |
Ouabain results in increased expression of ENDOG protein |
CTD |
PMID:31436044 |
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NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932
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G |
Ercc4 |
ERCC excision repair 4, endonuclease catalytic subunit |
decreases expression |
ISO |
Ouabain results in decreased expression of ERCC4 mRNA |
CTD |
PMID:24124520 |
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NCBI chr10:2,416,259...2,448,364
Ensembl chr10:2,419,038...2,448,369
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G |
Ets1 |
ETS proto-oncogene 1, transcription factor |
decreases expression |
ISO |
Ouabain results in decreased expression of ETS1 mRNA |
CTD |
PMID:28795476 |
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NCBI chr 8:31,045,909...31,168,010
Ensembl chr 8:31,045,945...31,168,010
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G |
Fadd |
Fas associated via death domain |
increases expression |
ISO |
Ouabain results in increased expression of FADD protein |
CTD |
PMID:31436044 |
|
NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
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G |
Fancd2 |
FA complementation group D2 |
multiple interactions decreases expression |
ISO |
Ouabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]; SB 203580 inhibits the reaction [Ouabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]] Ouabain results in decreased expression of FANCD2 mRNA |
CTD |
PMID:24124520 |
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NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412
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G |
Fancf |
FA complementation group F |
decreases expression |
ISO |
Ouabain results in decreased expression of FANCF mRNA |
CTD |
PMID:24124520 |
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NCBI chr 1:101,449,120...101,451,936
Ensembl chr 1:101,450,389...101,451,923
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G |
Fanci |
FA complementation group I |
decreases expression multiple interactions |
ISO |
Ouabain results in decreased expression of FANCI mRNA Ouabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCI protein] |
CTD |
PMID:24124520 |
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NCBI chr 1:133,327,264...133,383,661
Ensembl chr 1:133,327,297...133,383,640
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G |
Fars2 |
phenylalanyl-tRNA synthetase 2, mitochondrial |
increases expression |
ISO |
Ouabain results in increased expression of FARS2 mRNA |
CTD |
PMID:16412265 |
|
NCBI chr17:28,319,215...28,746,217
Ensembl chr17:28,319,280...28,746,337
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G |
Fas |
Fas cell surface death receptor |
increases expression |
ISO |
Ouabain results in increased expression of FAS protein |
CTD |
PMID:31436044 |
|
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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G |
Faslg |
Fas ligand |
increases expression |
ISO |
Ouabain results in increased expression of FASLG protein |
CTD |
PMID:31436044 |
|
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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G |
Fbxo32 |
F-box protein 32 |
multiple interactions |
ISO |
Ouabain affects the reaction [Botulinum Toxins, Type A affects the expression of FBXO32 mRNA] |
CTD |
PMID:21139329 |
|
NCBI chr 7:89,731,428...89,764,997
Ensembl chr 7:89,730,232...89,765,436
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G |
Fh |
fumarate hydratase |
affects expression |
ISO |
Ouabain affects the expression of FH protein |
CTD |
PMID:17268060 |
|
NCBI chr13:87,524,331...87,550,215
Ensembl chr13:87,524,337...87,550,266
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G |
Fkbp7 |
FKBP prolyl isomerase 7 |
increases expression |
ISO |
Ouabain results in increased expression of FKBP7 mRNA |
CTD |
PMID:16412265 |
|
NCBI chr 3:61,609,384...61,623,710
Ensembl chr 3:61,608,557...61,623,280
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G |
Fn1 |
fibronectin 1 |
decreases expression |
ISO |
Ouabain results in decreased expression of FN1 mRNA |
CTD |
PMID:28795476 |
|
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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G |
Gc |
GC, vitamin D binding protein |
affects expression |
ISO |
Ouabain affects the expression of GC protein |
CTD |
PMID:17268060 |
|
NCBI chr14:18,632,146...18,667,563
Ensembl chr14:18,632,135...18,667,567
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G |
Glrb |
glycine receptor, beta |
increases expression |
ISO |
Ouabain results in increased expression of GLRB mRNA |
CTD |
PMID:16412265 |
|
NCBI chr 2:166,134,616...166,207,498
Ensembl chr 2:166,134,626...166,207,489
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G |
Grb2 |
growth factor receptor bound protein 2 |
decreases expression |
ISO |
Ouabain results in decreased expression of GRB2 protein |
CTD |
PMID:28795476 |
|
NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309
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G |
Gtpbp6 |
GTP binding protein 6 (putative) |
increases expression |
ISO |
Ouabain results in increased expression of GTPBP6 mRNA |
CTD |
PMID:16412265 |
|
NCBI chr12:46,574,913...46,578,873
Ensembl chr12:46,574,435...46,578,873
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G |
H2ax |
H2A.X variant histone |
increases phosphorylation |
ISO |
Ouabain results in increased phosphorylation of H2AX protein |
CTD |
PMID:31436044 |
|
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
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G |
Hey1 |
hes-related family bHLH transcription factor with YRPW motif 1 |
increases expression |
ISO |
Ouabain results in increased expression of HEY1 mRNA |
CTD |
PMID:28795476 |
|
NCBI chr 2:93,096,605...93,100,316
Ensembl chr 2:93,095,498...93,100,312
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G |
Hgf |
hepatocyte growth factor |
multiple interactions |
EXP |
Ouabain inhibits the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide] |
CTD |
PMID:18031729 |
|
NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions increases activity affects localization |
ISO |
2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Ouabain affects the localization of HIF1A protein]; 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Ouabain results in increased phosphorylation of HIF1A protein]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Ouabain affects the localization of HIF1A protein]; KN 93 inhibits the reaction [Ouabain affects the localization of HIF1A protein]; KN 93 inhibits the reaction [Ouabain results in increased phosphorylation of HIF1A protein]; Ouabain results in increased phosphorylation of and results in increased expression of HIF1A protein Ouabain results in increased activity of HIF1A protein |
CTD |
PMID:19647009 |
|
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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G |
Hnrnpa2b1 |
heterogeneous nuclear ribonucleoprotein A2/B1 |
affects expression |
ISO |
Ouabain affects the expression of HNRNPA2B1 protein |
CTD |
PMID:17268060 |
|
NCBI chr 4:80,534,659...80,545,297
Ensembl chr 4:80,534,651...80,545,249
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G |
Hnrnpdl |
heterogeneous nuclear ribonucleoprotein D-like |
decreases expression |
ISO |
Ouabain results in decreased expression of HNRNPDL mRNA |
CTD |
PMID:16412265 |
|
NCBI chr14:9,557,430...9,563,659
Ensembl chr14:9,557,425...9,562,506
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G |
Hpcal1 |
hippocalcin-like 1 |
affects expression |
ISO |
Ouabain affects the expression of HPCAL1 protein |
CTD |
PMID:17268060 |
|
NCBI chr 6:40,478,206...40,584,721
Ensembl chr 6:40,478,208...40,584,687
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G |
Hrg |
histidine-rich glycoprotein |
affects expression |
ISO |
Ouabain affects the expression of HRG protein |
CTD |
PMID:17268060 |
|
NCBI chr11:78,054,488...78,069,402
Ensembl chr11:78,054,498...78,069,389
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
increases expression |
ISO |
Ouabain results in increased expression of HSPA5 protein |
CTD |
PMID:31436044 |
|
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Hspd1 |
heat shock protein family D (Hsp60) member 1 |
affects expression multiple interactions |
ISO |
Ouabain affects the expression of HSPD1 protein Ouabain inhibits the reaction [HSPD1 protein binds to BAX protein]; Ouabain results in decreased expression of and affects the localization of HSPD1 protein |
CTD |
PMID:17268060 PMID:18247327 |
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NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
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G |
Id2 |
inhibitor of DNA binding 2 |
increases expression |
ISO |
Ouabain results in increased expression of ID2 mRNA |
CTD |
PMID:28795476 |
|
NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
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G |
Il2ra |
interleukin 2 receptor subunit alpha |
decreases expression |
ISO |
Ouabain results in decreased expression of IL2RA mRNA |
CTD |
PMID:7593202 |
|
NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697
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G |
Il2rb |
interleukin 2 receptor subunit beta |
decreases expression |
ISO |
Ouabain results in decreased expression of IL2RB |
CTD |
PMID:7593202 |
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NCBI chr 7:110,033,341...110,048,054
Ensembl chr 7:110,033,341...110,048,054
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G |
Il6 |
interleukin 6 |
increases secretion increases expression |
ISO |
Ouabain results in increased secretion of IL6 protein Ouabain results in increased expression of IL6 mRNA |
CTD |
PMID:33760381 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Il6r |
interleukin 6 receptor |
increases expression |
ISO |
Ouabain results in increased expression of IL6R mRNA |
CTD |
PMID:33760381 |
|
NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
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G |
Ilk |
integrin-linked kinase |
decreases expression |
ISO |
Ouabain results in decreased expression of ILK mRNA |
CTD |
PMID:28795476 |
|
NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140
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G |
Itgav |
integrin subunit alpha V |
decreases expression |
ISO |
Ouabain results in decreased expression of ITGAV mRNA |
CTD |
PMID:28795476 |
|
NCBI chr 3:68,838,514...68,926,653
Ensembl chr 3:68,838,189...68,926,639
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
decreases expression decreases phosphorylation |
ISO |
Ouabain results in decreased expression of JUN mRNA Ouabain results in decreased phosphorylation of JUN protein |
CTD |
PMID:28795476 |
|
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Kcnd2 |
potassium voltage-gated channel subfamily D member 2 |
increases expression |
ISO EXP |
Ouabain results in increased expression of KCND2 mRNA |
CTD |
PMID:16412265 |
|
NCBI chr 4:49,775,812...50,277,746
Ensembl chr 4:49,776,246...50,277,728
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G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
decreases expression multiple interactions decreases activity |
ISO |
Ouabain results in decreased expression of KCNH2 protein modified form Ouabain inhibits the reaction [KCNH2 protein results in increased transport of Thallium] Ouabain results in decreased activity of KCNH2 protein |
CTD |
PMID:19139152 PMID:21158687 |
|
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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G |
Lef1 |
lymphoid enhancer binding factor 1 |
decreases expression |
ISO |
Ouabain results in decreased expression of LEF1 mRNA |
CTD |
PMID:28795476 |
|
NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794
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G |
Lgals1 |
galectin 1 |
affects expression increases expression |
ISO |
Ouabain affects the expression of LGALS1 protein Ouabain results in increased expression of LGALS1 protein |
CTD |
PMID:17268060 PMID:18247327 |
|
NCBI chr 7:110,485,239...110,488,345
Ensembl chr 7:110,481,392...110,488,345
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|
G |
Limk1 |
LIM domain kinase 1 |
decreases expression |
ISO |
Ouabain results in decreased expression of LIMK1 mRNA |
CTD |
PMID:28795476 |
|
NCBI chr12:22,026,697...22,060,605
Ensembl chr12:22,026,672...22,060,606
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G |
Lss |
lanosterol synthase |
increases abundance |
ISO |
LSS protein results in increased abundance of Ouabain |
CTD |
PMID:21106941 |
|
NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762
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G |
Map2k6 |
mitogen-activated protein kinase kinase 6 |
increases expression |
ISO |
Ouabain results in increased expression of MAP2K6 mRNA |
CTD |
PMID:28795476 |
|
NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions increases phosphorylation decreases phosphorylation |
EXP ISO |
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased phosphorylation of MAPK1 protein] Ouabain results in decreased phosphorylation of MAPK1 protein |
CTD |
PMID:19687166 PMID:28795476 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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|
G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions increases phosphorylation decreases phosphorylation |
EXP ISO |
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased phosphorylation of MAPK3 protein] Ouabain results in decreased phosphorylation of MAPK3 protein |
CTD |
PMID:19687166 PMID:28795476 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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|
G |
Mapk7 |
mitogen-activated protein kinase 7 |
multiple interactions |
ISO |
Ouabain inhibits the reaction [palytoxin results in increased phosphorylation of and results in increased activity of MAPK7 protein] |
CTD |
PMID:19716839 |
|
NCBI chr10:46,170,264...46,176,262
Ensembl chr10:46,170,167...46,176,267
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|
G |
Mdh2 |
malate dehydrogenase 2 |
affects expression |
ISO |
Ouabain affects the expression of MDH2 protein |
CTD |
PMID:17268060 |
|
NCBI chr12:20,894,269...20,907,225
Ensembl chr12:20,894,262...20,907,271
|
|
G |
Mdm2 |
MDM2 proto-oncogene |
multiple interactions |
ISO |
Ouabain results in decreased expression of and results in decreased phosphorylation of MDM2 protein |
CTD |
PMID:31436044 |
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NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
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G |
Mgmt |
O-6-methylguanine-DNA methyltransferase |
decreases expression |
ISO |
Ouabain results in decreased expression of MGMT protein |
CTD |
PMID:31436044 |
|
NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
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G |
Mir29b1 |
microRNA 29b-1 |
multiple interactions decreases expression |
EXP |
MIR29B1 mRNA inhibits the reaction [Ouabain results in increased expression of COL1A1 mRNA] Ouabain results in decreased expression of MIR29B1 mRNA |
CTD |
PMID:26702050 |
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NCBI chr 4:59,650,987...59,651,067
Ensembl chr 4:59,650,986...59,651,067
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G |
Mmp13 |
matrix metallopeptidase 13 |
decreases expression |
ISO |
Ouabain results in decreased expression of MMP13 mRNA |
CTD |
PMID:28795476 |
|
NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
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G |
Mmp2 |
matrix metallopeptidase 2 |
decreases expression multiple interactions |
ISO |
Ouabain results in decreased expression of MMP2 mRNA Ouabain results in decreased expression of and results in decreased activity of MMP2 protein |
CTD |
PMID:28795476 |
|
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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G |
Mmp9 |
matrix metallopeptidase 9 |
decreases expression |
ISO |
Ouabain results in decreased expression of MMP9 mRNA; Ouabain results in decreased expression of MMP9 protein |
CTD |
PMID:28795476 PMID:33760381 |
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NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Mras |
muscle RAS oncogene homolog |
decreases expression |
ISO |
Ouabain results in decreased expression of MRAS mRNA |
CTD |
PMID:28795476 |
|
NCBI chr 8:99,944,036...100,006,771
Ensembl chr 8:99,944,036...99,996,408
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G |
Mrtfa |
myocardin related transcription factor A |
decreases expression |
ISO |
Ouabain results in decreased expression of MRTFA mRNA |
CTD |
PMID:28795476 |
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NCBI chr 7:112,544,305...112,714,418
Ensembl chr 7:112,544,312...112,714,418
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G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
decreases expression increases expression |
ISO |
Ouabain results in decreased expression of MYC mRNA; Ouabain results in decreased expression of MYC protein Ouabain results in increased expression of MYC protein |
CTD |
PMID:9653513 PMID:21215801 |
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NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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G |
Myl12a |
myosin light chain 12A |
increases expression |
ISO |
Ouabain results in increased expression of MYL12A protein |
CTD |
PMID:17268060 |
|
NCBI chr 9:110,891,970...110,899,655
Ensembl chr 9:110,873,959...110,916,580
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G |
Mylk |
myosin light chain kinase |
decreases expression |
ISO |
Ouabain results in decreased expression of MYLK mRNA |
CTD |
PMID:28795476 |
|
NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261
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G |
Nectin3 |
nectin cell adhesion molecule 3 |
decreases expression |
ISO |
Ouabain results in decreased expression of NECTIN3 mRNA |
CTD |
PMID:28795476 |
|
NCBI chr11:54,362,712...54,469,351
Ensembl chr11:54,364,487...54,462,519
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G |
Nectin4 |
nectin cell adhesion molecule 4 |
increases expression |
ISO |
Ouabain results in increased expression of NECTIN4 mRNA |
CTD |
PMID:28795476 |
|
NCBI chr13:83,802,589...83,821,711
Ensembl chr13:83,803,184...83,821,709
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G |
Nefl |
neurofilament light chain |
decreases expression |
ISO |
Ouabain results in decreased expression of NEFL mRNA |
CTD |
PMID:28795476 |
|
NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793
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G |
Nos1 |
nitric oxide synthase 1 |
affects expression increases expression |
EXP |
Ouabain affects the expression of NOS1 protein Ouabain results in increased expression of NOS1 protein |
CTD |
PMID:12384489 PMID:15097235 |
|
NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
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G |
Nos3 |
nitric oxide synthase 3 |
multiple interactions increases expression affects expression |
EXP |
5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide inhibits the reaction [Ouabain results in increased expression of NOS3 protein] Ouabain affects the expression of NOS3 protein |
CTD |
PMID:12384489 PMID:15477225 |
|
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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G |
Npc2 |
NPC intracellular cholesterol transporter 2 |
decreases expression |
ISO |
Ouabain results in decreased expression of NPC2 mRNA |
CTD |
PMID:16412265 |
|
NCBI chr 6:104,397,239...104,418,161
Ensembl chr 6:104,378,644...104,418,155
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G |
Nppa |
natriuretic peptide A |
increases expression multiple interactions |
EXP |
Ouabain results in increased expression of NPPA mRNA N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased expression of NPPA mRNA]; Ouabain promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA] |
CTD |
PMID:17266992 PMID:19687166 |
|
NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
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G |
Nras |
NRAS proto-oncogene, GTPase |
decreases expression |
ISO |
Ouabain results in decreased expression of NRAS mRNA |
CTD |
PMID:28795476 |
|
NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626
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G |
Park7 |
Parkinsonism associated deglycase |
affects response to substance |
ISO |
PARK7 affects the susceptibility to Ouabain |
CTD |
PMID:16624565 |
|
NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions increases cleavage |
ISO |
Mitomycin promotes the reaction [Ouabain results in increased cleavage of PARP1 protein]; Ouabain promotes the reaction [Mitomycin results in increased cleavage of PARP1 protein] |
CTD |
PMID:24124520 PMID:31436044 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pcna |
proliferating cell nuclear antigen |
decreases expression |
ISO |
Ouabain results in decreased expression of PCNA mRNA; Ouabain results in decreased expression of PCNA protein |
CTD |
PMID:20460749 PMID:21215801 |
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NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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G |
Pdcd6 |
programmed cell death 6 |
increases expression |
ISO |
Ouabain results in increased expression of PDCD6 protein |
CTD |
PMID:18247327 |
|
NCBI chr 1:28,966,518...28,982,188
Ensembl chr 1:28,966,518...28,982,189
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G |
Pfdn5 |
prefoldin subunit 5 |
affects expression |
ISO |
Ouabain affects the expression of PFDN5 protein |
CTD |
PMID:17268060 |
|
NCBI chr 7:133,451,778...133,456,516
Ensembl chr 7:133,451,453...133,456,516
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G |
Pfn1 |
profilin 1 |
affects expression decreases expression |
ISO |
Ouabain affects the expression of PFN1 protein Ouabain results in decreased expression of PFN1 protein |
CTD |
PMID:17268060 PMID:18247327 |
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NCBI chr10:55,365,263...55,367,968
Ensembl chr10:55,365,262...55,527,631
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G |
Plaur |
plasminogen activator, urokinase receptor |
decreases expression |
ISO |
Ouabain results in decreased expression of PLAUR mRNA |
CTD |
PMID:28795476 |
|
NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595
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G |
Plcg1 |
phospholipase C, gamma 1 |
decreases expression |
ISO |
Ouabain results in decreased expression of PLCG1 mRNA |
CTD |
PMID:28795476 |
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NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330
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G |
Ppt2 |
palmitoyl-protein thioesterase 2 |
decreases expression |
ISO |
Ouabain results in decreased expression of PPT2 mRNA |
CTD |
PMID:16412265 |
|
NCBI chr20:4,112,520...4,132,774
Ensembl chr20:4,122,463...4,132,774
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G |
Prkdc |
protein kinase, DNA-activated, catalytic subunit |
decreases expression |
ISO |
Ouabain results in decreased expression of PRKDC protein |
CTD |
PMID:31436044 |
|
NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952
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G |
Psmb6 |
proteasome 20S subunit beta 6 |
affects expression |
ISO |
Ouabain affects the expression of PSMB6 protein |
CTD |
PMID:17268060 |
|
NCBI chr10:55,239,256...55,241,586
Ensembl chr10:55,239,241...55,241,586
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions increases expression |
EXP |
[Ouabain results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Nitric Oxide |
CTD |
PMID:18976649 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Ptpn2 |
protein tyrosine phosphatase, non-receptor type 2 |
decreases expression |
ISO |
Ouabain results in decreased expression of PTPN2 mRNA |
CTD |
PMID:16412265 |
|
NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627
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G |
Rab11b |
RAB11B, member RAS oncogene family |
increases expression |
ISO |
Ouabain results in increased expression of RAB11B protein |
CTD |
PMID:18247327 |
|
NCBI chr 7:14,521,448...14,534,589
Ensembl chr 7:14,521,368...14,534,593
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G |
Raf1 |
Raf-1 proto-oncogene, serine/threonine kinase |
decreases expression |
ISO |
Ouabain results in decreased expression of RAF1 mRNA |
CTD |
PMID:28795476 |
|
NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
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G |
Rasgrf1 |
RAS protein-specific guanine nucleotide-releasing factor 1 |
decreases expression |
ISO |
Ouabain results in decreased expression of RASGRF1 mRNA |
CTD |
PMID:28795476 |
|
NCBI chr 8:90,445,154...90,574,274
Ensembl chr 8:90,445,154...90,574,269
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G |
Rgs2 |
regulator of G-protein signaling 2 |
decreases expression |
ISO |
Ouabain results in decreased expression of RGS2 mRNA |
CTD |
PMID:28795476 |
|
NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385
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G |
Rhoh |
ras homolog family member H |
increases expression |
ISO |
Ouabain results in increased expression of RHOH mRNA |
CTD |
PMID:28795476 |
|
NCBI chr14:42,341,135...42,371,971
Ensembl chr14:42,337,751...42,386,369
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G |
Rock1 |
Rho-associated coiled-coil containing protein kinase 1 |
increases cleavage multiple interactions |
ISO |
Ouabain results in increased cleavage of ROCK1 protein benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Ouabain results in increased cleavage of ROCK1 protein] |
CTD |
PMID:20661774 |
|
NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571
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G |
Rock2 |
Rho-associated coiled-coil containing protein kinase 2 |
multiple interactions increases cleavage |
ISO |
benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [Ouabain results in increased cleavage of ROCK2 protein] |
CTD |
PMID:20661774 |
|
NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031
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G |
Rpa3 |
replication protein A3 |
affects expression |
ISO |
Ouabain affects the expression of RPA3 protein |
CTD |
PMID:17268060 |
|
NCBI chr 4:36,304,649...36,307,755
Ensembl chr 4:36,304,651...36,307,709
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G |
Rpgrip1l |
Rpgrip1-like |
decreases expression |
ISO |
Ouabain results in decreased expression of RPGRIP1L mRNA |
CTD |
PMID:16412265 |
|
NCBI chr19:15,692,189...15,785,083
Ensembl chr19:15,692,150...15,785,083
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G |
Rps6kb1 |
ribosomal protein S6 kinase B1 |
affects expression |
EXP |
Ouabain affects the expression of RPS6KB1 mRNA |
CTD |
PMID:28099878 |
|
NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
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G |
Ryr2 |
ryanodine receptor 2 |
multiple interactions increases response to substance |
ISO |
K201 compound inhibits the reaction [RYR2 mutant form results in increased susceptibility to Ouabain] |
CTD |
PMID:20080988 |
|
NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142
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G |
S100a13 |
S100 calcium binding protein A13 |
affects expression |
ISO |
Ouabain affects the expression of S100A13 protein |
CTD |
PMID:17268060 |
|
NCBI chr 2:175,999,439...176,005,933
|
|
G |
S100b |
S100 calcium binding protein B |
increases expression |
EXP |
Ouabain results in increased expression of S100B protein |
CTD |
PMID:15581912 |
|
NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743
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G |
Sgk1 |
serum/glucocorticoid regulated kinase 1 |
multiple interactions decreases expression |
ISO |
Ouabain inhibits the reaction [SGK1 protein results in increased transport of Potassium] Ouabain results in decreased expression of SGK1 mRNA |
CTD |
PMID:12590200 PMID:28795476 |
|
NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
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G |
Sgk2 |
serum/glucocorticoid regulated kinase 2 |
multiple interactions |
ISO |
Ouabain inhibits the reaction [SGK2 protein results in increased transport of Potassium] |
CTD |
PMID:12590200 |
|
NCBI chr 3:151,644,102...151,669,480
Ensembl chr 3:151,644,102...151,669,480
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G |
Sgk3 |
serum/glucocorticoid regulated kinase family, member 3 |
multiple interactions |
ISO |
Ouabain inhibits the reaction [SGK3 protein results in increased transport of Potassium] |
CTD |
PMID:12590200 |
|
NCBI chr 5:9,345,761...9,472,243
Ensembl chr 5:9,346,040...9,415,476
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G |
Shc3 |
SHC adaptor protein 3 |
increases expression |
ISO |
Ouabain results in increased expression of SHC3 mRNA |
CTD |
PMID:28795476 |
|
NCBI chr17:13,652,247...13,772,710
Ensembl chr17:13,651,202...13,772,710
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G |
Slc16a1 |
solute carrier family 16 member 1 |
multiple interactions |
ISO |
Ouabain inhibits the reaction [SLC16A1 protein results in increased uptake of Lactic Acid] |
CTD |
PMID:15804185 |
|
NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611
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G |
Slc22a12 |
solute carrier family 22 member 12 |
multiple interactions |
ISO |
Ouabain promotes the reaction [SLC22A12 protein results in increased uptake of p-Aminohippuric Acid] |
CTD |
PMID:15284287 |
|
NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555
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G |
Slc5a5 |
solute carrier family 5 member 5 |
multiple interactions |
ISO |
Ouabain inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide] |
CTD |
PMID:12541134 |
|
NCBI chr16:18,546,709...18,556,698
Ensembl chr16:18,546,709...18,556,697
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G |
Slc5a6 |
solute carrier family 5 member 6 |
multiple interactions |
ISO |
Ouabain inhibits the reaction [SLC5A6 protein results in increased transport of Biotin] |
CTD |
PMID:15561972 |
|
NCBI chr 6:25,319,187...25,331,713
Ensembl chr 6:25,320,442...25,331,712
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G |
Slc8a1 |
solute carrier family 8 member A1 |
affects response to substance multiple interactions increases expression |
ISO EXP |
SLC8A1 affects the susceptibility to Ouabain SLC8A1 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of SLC8A1 protein]; SLC8A1 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of TRPC6 protein]; TRPC6 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of SLC8A1 protein] |
CTD |
PMID:16166162 PMID:19897708 |
|
NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628
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G |
Slc9a1 |
solute carrier family 9 member A1 |
multiple interactions increases expression |
EXP |
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased expression of SLC9A1 mRNA] |
CTD |
PMID:19687166 |
|
NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624
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|
G |
Smad4 |
SMAD family member 4 |
decreases expression |
ISO |
Ouabain results in decreased expression of SMAD4 mRNA |
CTD |
PMID:28795476 |
|
NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438
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G |
Snai1 |
snail family transcriptional repressor 1 |
decreases expression |
ISO |
Ouabain results in decreased expression of SNAI1 mRNA |
CTD |
PMID:33760381 |
|
NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
|
|
G |
Sos1 |
SOS Ras/Rac guanine nucleotide exchange factor 1 |
decreases expression |
ISO |
Ouabain results in decreased expression of SOS1 protein |
CTD |
PMID:28795476 |
|
NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107
|
|
G |
Sos2 |
SOS Ras/Rho guanine nucleotide exchange factor 2 |
decreases expression |
ISO |
Ouabain results in decreased expression of SOS2 mRNA |
CTD |
PMID:28795476 |
|
NCBI chr 6:88,042,966...88,156,140
Ensembl chr 6:88,042,966...88,156,692
|
|
G |
Sphk1 |
sphingosine kinase 1 |
decreases expression |
ISO |
Ouabain results in decreased expression of SPHK1 mRNA |
CTD |
PMID:28795476 |
|
NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240
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|
G |
Tgfb1 |
transforming growth factor, beta 1 |
decreases expression |
ISO |
Ouabain results in decreased expression of TGFB1 mRNA |
CTD |
PMID:28795476 |
|
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
|
|
G |
Tgfb2 |
transforming growth factor, beta 2 |
decreases expression |
ISO |
Ouabain results in decreased expression of TGFB2 mRNA |
CTD |
PMID:28795476 |
|
NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
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G |
Tgfb3 |
transforming growth factor, beta 3 |
decreases expression |
ISO |
Ouabain results in decreased expression of TGFB3 mRNA |
CTD |
PMID:28795476 |
|
NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564
|
|
G |
Tgfbr3 |
transforming growth factor beta receptor 3 |
increases expression |
ISO |
Ouabain results in increased expression of TGFBR3 mRNA |
CTD |
PMID:28795476 |
|
NCBI chr14:2,489,397...2,665,383
Ensembl chr14:2,489,397...2,663,341
|
|
G |
Tln1 |
talin 1 |
decreases expression |
ISO |
Ouabain results in decreased expression of TLN1 mRNA |
CTD |
PMID:28795476 |
|
NCBI chr 5:57,787,670...57,817,900
Ensembl chr 5:57,787,943...57,817,900
|
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G |
Tln2 |
talin 2 |
decreases expression |
ISO |
Ouabain results in decreased expression of TLN2 mRNA |
CTD |
PMID:28795476 |
|
NCBI chr 8:67,830,920...68,252,240
Ensembl chr 8:67,834,326...68,252,219
|
|
G |
Tnfrsf10b |
TNF receptor superfamily member 10b |
increases expression |
ISO |
Ouabain results in increased expression of TNFRSF10A protein |
CTD |
PMID:31436044 |
|
NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467
|
|
G |
Tp53 |
tumor protein p53 |
multiple interactions |
ISO |
Ouabain results in decreased expression of and results in increased phosphorylation of TP53 protein |
CTD |
PMID:31436044 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
|
|
G |
Tpi1 |
triosephosphate isomerase 1 |
affects expression |
ISO |
Ouabain affects the expression of TPI1 protein |
CTD |
PMID:17268060 |
|
NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541
|
|
G |
Tpt1 |
tumor protein, translationally-controlled 1 |
affects expression |
ISO |
Ouabain affects the expression of TPT1 protein |
CTD |
PMID:17268060 |
|
NCBI chr15:51,156,728...51,159,629
Ensembl chr15:51,146,154...51,159,625
|
|
G |
Trim63 |
tripartite motif containing 63 |
multiple interactions |
ISO |
[Ouabain co-treated with Botulinum Toxins, Type A] affects the expression of TRIM63 mRNA |
CTD |
PMID:21139329 |
|
NCBI chr 5:146,533,492...146,547,332
Ensembl chr 5:146,533,507...146,547,322
|
|
G |
Trpc1 |
transient receptor potential cation channel, subfamily C, member 1 |
increases expression |
EXP |
Ouabain results in increased expression of TRPC1 protein |
CTD |
PMID:19897708 |
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NCBI chr 8:96,263,322...96,314,220
Ensembl chr 8:96,263,329...96,314,276
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G |
Trpc6 |
transient receptor potential cation channel, subfamily C, member 6 |
increases expression multiple interactions |
EXP |
Ouabain results in increased expression of TRPC6 protein SLC8A1 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of TRPC6 protein]; TRPC6 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of SLC8A1 protein]; TRPC6 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of TRPC6 protein] |
CTD |
PMID:19897708 |
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NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092
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G |
Twist1 |
twist family bHLH transcription factor 1 |
increases expression |
ISO |
Ouabain results in increased expression of TWIST1 mRNA |
CTD |
PMID:33760381 |
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NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653
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G |
Txn1 |
thioredoxin 1 |
affects expression |
ISO |
Ouabain affects the expression of TXN protein |
CTD |
PMID:17268060 |
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NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
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G |
Vim |
vimentin |
decreases expression |
ISO |
Ouabain results in decreased expression of VIM mRNA |
CTD |
PMID:33760381 |
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NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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G |
Zfhx3 |
zinc finger homeobox 3 |
decreases expression |
ISO |
Ouabain results in decreased expression of ZFHX3 mRNA |
CTD |
PMID:16412265 |
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NCBI chr19:36,257,196...36,886,104
Ensembl chr19:36,630,254...36,881,771
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
increases transport |
ISO |
ABCB1 protein results in increased transport of Strophanthidin |
CTD |
PMID:26708294 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
G6pc1 |
glucose-6-phosphatase catalytic subunit 1 |
increases expression multiple interactions |
ISO |
Strophanthidin results in increased expression of G6PC1 mRNA Strophanthidin promotes the reaction [RORC protein binds to G6PC1 promoter] |
CTD |
PMID:29981919 |
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NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
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G |
Il17a |
interleukin 17A |
multiple interactions |
ISO |
Strophanthidin results in increased expression of and results in increased secretion of IL17A protein |
CTD |
PMID:29981919 |
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NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
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G |
Il17f |
interleukin 17F |
multiple interactions |
ISO |
Strophanthidin results in increased expression of and results in increased secretion of IL17F protein |
CTD |
PMID:29981919 |
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NCBI chr 9:23,190,094...23,201,482
Ensembl chr 9:23,190,100...23,201,482
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G |
Npas2 |
neuronal PAS domain protein 2 |
increases expression multiple interactions |
ISO |
Strophanthidin results in increased expression of NPAS2 mRNA Strophanthidin promotes the reaction [RORC protein binds to NPAS2 promoter] |
CTD |
PMID:29981919 |
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NCBI chr 9:41,463,361...41,642,322
Ensembl chr 9:41,463,830...41,642,320
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G |
Rorc |
RAR-related orphan receptor C |
multiple interactions increases expression |
ISO |
RORC protein promotes the reaction [Strophanthidin results in increased expression of RORC mRNA]; Strophanthidin promotes the reaction [RORC protein binds to G6PC1 promoter]; Strophanthidin promotes the reaction [RORC protein binds to NPAS2 promoter] |
CTD |
PMID:29981919 |
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NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907
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