Dsg1 (desmoglein 1) - Rat Genome Database

Name: Dsg1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Dsg1 (desmoglein 1) Rattus norvegicus

Analyze

Symbol:

Dsg1

Name:

desmoglein 1

RGD ID:

1309925

Description:

Predicted to enable calcium ion binding activity and gamma-catenin binding activity. Involved in maternal process involved in female pregnancy and response to progesterone. Located in apical plasma membrane and lateral plasma membrane. Human ortholog(s) of this gene implicated in keratosis palmoplantaris striata 1. Orthologous to human DSG1 (desmoglein 1); PARTICIPATES IN Staphylococcus aureus infection pathway; INTERACTS WITH 1-naphthyl isothiocyanate; bisphenol A; fenvalerate.

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

desmoglein 1 beta; desmoglein 1 gamma; desmoglein-1; Dsg1b; Dsg1c; LOC291755

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DSG1 (desmoglein 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Dsg1a (desmoglein 1 alpha)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Dsg1 (desmoglein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DSG1 (desmoglein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DSG1 (desmoglein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Dsg1 (desmoglein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DSG1 (desmoglein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	DSG1 (desmoglein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Dsg1 (desmoglein 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	DSG1 (desmoglein 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Dsg1c (desmoglein 1 gamma)	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Mus musculus (house mouse):	Dsg1a (desmoglein 1 alpha)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Dsg1b (desmoglein 1 beta)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	si:ch73-74h11.1	Alliance	DIOPT (InParanoid\|OrthoFinder\|PANTHER\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	18	11,674,687 - 11,705,383 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	11,674,402 - 11,703,443 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	18	12,008,301 - 12,040,337 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	12,008,759 - 12,038,053 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	11,807,285 - 11,838,204 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	12,127,180 - 12,156,469 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	12,096,380 - 12,182,381 (+)	NCBI
Celera	18	11,690,076 - 11,721,312 (+)	NCBI		Celera
Cytogenetic Map	18	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

allergic disease (ISO)

Chronic Periodontitis (ISO)

Congenital Erythroderma with Palmoplantar Keratoderma, Hypotrichosis, and Hyper-IgE (ISO)

dermatitis (ISO)

disease of metabolism (ISO)

genetic disease (ISO)

intellectual disability (ISO)

keratosis palmoplantaris striata 1 (ISO)

palmoplantar keratoderma-deafness syndrome (ISO)

Reperfusion Injury (IEP)

transthyretin amyloidosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

antimonite (ISO)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

atrazine (ISO)

avobenzone (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

cadmium atom (ISO)

CGP 52608 (ISO)

cortisol (ISO)

dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate (ISO)

epoxiconazole (ISO)

fenvalerate (EXP)

lead(0) (ISO)

lead(2+) (ISO)

levonorgestrel (ISO)

methylmercury chloride (ISO)

ouabain (ISO)

perfluorooctane-1-sulfonic acid (ISO)

pinosylvin (ISO)

resveratrol (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium dodecyl sulfate (ISO)

testosterone undecanoate (ISO)

trans-pinosylvin (ISO)

trichloroethene (EXP)

triclosan (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell-cell adhesion (IBA)

homophilic cell adhesion via plasma membrane adhesion molecules (IEA)

maternal process involved in female pregnancy (IEP)

protein stabilization (ISO)

response to progesterone (IEP)

Cellular Component

apical plasma membrane (IDA)

cell-cell junction (ISO)

cytoplasm (ISO)

cytoplasmic side of plasma membrane (ISO)

desmosome (IBA,ISO)

lateral plasma membrane (IDA)

nucleus (ISO)

plasma membrane (ISO)

Molecular Function

calcium ion binding (IBA)

gamma-catenin binding (IBA,ISO)

molecular_function (ND)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

Staphylococcus aureus infection pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Altered gene expression in leukocyte transendothelial migration and cell communication pathways in periodontitis-affected gingival tissues.	Abe D, etal., J Periodontal Res. 2011 Jun;46(3):345-53. doi: 10.1111/j.1600-0765.2011.01349.x. Epub 2011 Mar 7.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
6.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
7.	Progesterone treatment and the progress of early pregnancy reduce desmoglein 1&2 staining along the lateral plasma membrane in rat uterine epithelial cells.	Preston AM, etal., Acta Histochem. 2004;106(5):345-51.
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Comprehensive gene review and curation	RGD comprehensive gene curation
11.	N-terminal deletion in a desmosomal cadherin causes the autosomal dominant skin disease striate palmoplantar keratoderma.	Rickman L, etal., Hum Mol Genet. 1999 Jun;8(6):971-6.
12.	Coordinated reassembly of the basement membrane and junctional proteins during corneal epithelial wound healing.	Suzuki K, etal., Invest Ophthalmol Vis Sci. 2000 Aug;41(9):2495-500.
13.	Cell-cell junctions and vascular endothelial growth factor in rat lung as affected by ischemia/reperfusion and preconditioning with inhaled nitric oxide.	Waldow T, etal., J Surg Res. 2009 Nov;157(1):30-42. Epub 2008 Sep 4.

Additional References at PubMed

PMID:7983064	PMID:12093888	PMID:12631242	PMID:14673151	PMID:15775979	PMID:23376485	PMID:23979707	PMID:25931508

Genomics

Comparative Map Data

Dsg1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	18	11,674,687 - 11,705,383 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	18	11,674,402 - 11,703,443 (+)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	18	12,008,301 - 12,040,337 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	18	12,008,759 - 12,038,053 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	18	11,807,285 - 11,838,204 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	18	12,127,180 - 12,156,469 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	18	12,096,380 - 12,182,381 (+)	NCBI
Celera	18	11,690,076 - 11,721,312 (+)	NCBI		Celera
Cytogenetic Map	18	p12	NCBI

DSG1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	18	31,318,160 - 31,359,246 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	18	31,318,160 - 31,359,246 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	18	28,898,123 - 28,939,209 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	18	27,152,050 - 27,191,392 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	18	27,152,049 - 27,190,453	NCBI
Celera	18	25,705,178 - 25,744,520 (+)	NCBI		Celera
Cytogenetic Map	18	q12.1	NCBI
HuRef	18	25,754,044 - 25,793,387 (+)	NCBI		HuRef
CHM1_1	18	28,825,336 - 28,864,663 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	18	31,508,717 - 31,549,794 (+)	NCBI		T2T-CHM13v2.0

Dsg1a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	18	20,443,930 - 20,476,410 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	18	20,443,868 - 20,476,407 (+)	Ensembl		GRCm39 Ensembl
GRCm38	18	20,310,873 - 20,343,353 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	18	20,310,811 - 20,343,350 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	18	20,469,374 - 20,501,854 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	18	20,453,821 - 20,486,363 (+)	NCBI		MGSCv36	mm8
Celera	18	20,815,287 - 20,847,880 (+)	NCBI		Celera
Cytogenetic Map	18	A2	NCBI
cM Map	18	11.29	NCBI

Dsg1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955402	18,668,196 - 18,700,630 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955402	18,668,717 - 18,704,329 (+)	NCBI	ChiLan1.0	ChiLan1.0

DSG1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	18	28,140,132 - 28,171,831 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	18	28,078,131 - 28,175,803 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	18	24,543,061 - 24,579,085 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

DSG1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	58,159,283 - 58,239,018 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	58,102,113 - 58,193,708 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	57,597,684 - 57,630,602 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	58,144,506 - 58,179,775 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	58,147,900 - 58,178,837 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	57,822,159 - 57,855,070 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	57,848,322 - 57,881,239 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	58,137,415 - 58,170,337 (-)	NCBI		UU_Cfam_GSD_1.0

Dsg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404944	53,853,056 - 53,887,806 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936682	1,853,594 - 1,889,488 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936682	1,854,637 - 1,889,426 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DSG1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	115,237,677 - 115,276,645 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	115,237,836 - 115,272,944 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	107,865,594 - 107,900,704 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

DSG1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	18	49,372,261 - 49,408,818 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	18	49,375,262 - 49,406,742 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	24,016,372 - 24,052,276 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Dsg1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624770	1,517,027 - 1,542,322 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624770	1,514,978 - 1,551,437 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Dsg1
249 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	296
Count of miRNA genes:	143
Interacting mature miRNAs:	161
Transcripts:	ENSRNOT00000022665, ENSRNOT00000038635, ENSRNOT00000061344
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
8552968	Pigfal19	Plasma insulin-like growth factor 1 level QTL 19	11.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	18	1	25758124	Rat
9590248	Scort10	Serum corticosterone level QTL 10	19.71	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	18	1	25758124	Rat
2312598	Bp340	Blood pressure QTL 340		0.05	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	18	1	30558703	Rat
2300180	Bmd67	Bone mineral density QTL 67	4.8	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	18	1	34291613	Rat
2293661	Bss50	Bone structure and strength QTL 50	4.64	0.0003	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	18	1	34291613	Rat
61388	Bp2	Blood pressure QTL 2	3.23		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	18	1	35374722	Rat
9589153	Insul31	Insulin level QTL 31	7.15	0.05	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	18	1	42547119	Rat
1641910	Colcr3	Colorectal carcinoma resistance QTL 3	5.02	0.000007	intestine integrity trait (VT:0010554)	poorly differentiated malignant colorectal tumor surface area measurement (CMO:0002078)	18	2249477	22066430	Rat
1641910	Colcr3	Colorectal carcinoma resistance QTL 3	5.02	0.000007	intestine integrity trait (VT:0010554)	poorly differentiated malignant colorectal tumor number (CMO:0002076)	18	2249477	22066430	Rat
2299160	Iddm35	Insulin dependent diabetes mellitus QTL 35	2.79		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	18	4207941	60377792	Rat
2312568	Glom21	Glomerulus QTL 21	2	0.005	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	18	5185858	40503530	Rat
11565454	Kidm59	Kidney mass QTL 59		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	18	6791251	12205285	Rat
12904714	Cm131	Cardiac mass QTL 131		0.002	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	18	6791251	12205285	Rat
12904715	Cm132	Cardiac mass QTL 132		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	18	6791251	12205285	Rat
12904716	Am21	Aortic mass QTL 21		0.005	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	18	6791251	12205285	Rat
2301409	Cm70	Cardiac mass QTL 70		0.001	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	18	6791251	12205285	Rat

Markers in Region

RH137413

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	11,703,221 - 11,703,416 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	12,038,177 - 12,038,371	NCBI	Rnor6.0
Rnor_5.0	18	11,836,044 - 11,836,238	UniSTS	Rnor5.0
RGSC_v3.4	18	12,155,859 - 12,156,053	UniSTS	RGSC3.4
Celera	18	11,719,152 - 11,719,346	UniSTS
RH 3.4 Map	18	133.11	UniSTS
Cytogenetic Map	18	p12	UniSTS

RH142083

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	18	11,703,889 - 11,704,109 (+)	MAPPER	mRatBN7.2
Rnor_6.0	18	12,038,845 - 12,039,064	NCBI	Rnor6.0
Rnor_5.0	18	11,836,712 - 11,836,931	UniSTS	Rnor5.0
RGSC_v3.4	18	12,156,527 - 12,156,746	UniSTS	RGSC3.4
Celera	18	11,719,820 - 11,720,039	UniSTS
RH 3.4 Map	18	133.7	UniSTS
Cytogenetic Map	18	p12	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium			2	2		2						6
Low	1		15	15	11	15	1	1	12	10	7	1	1
Below cutoff	2	4	27	19	8	19	3	3	36	8	20	3	3

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_017587844	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017601072	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039097378	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACYVU010000299	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000022665 ⟹ ENSRNOP00000022665

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	18	12,008,759 - 12,037,765 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000038635 ⟹ ENSRNOP00000030176

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	18	12,008,759 - 12,038,053 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000061344 ⟹ ENSRNOP00000058060

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	18	11,674,402 - 11,703,443 (+)	Ensembl
Rnor_6.0 Ensembl	18	12,008,759 - 12,038,053 (+)	Ensembl

RefSeq Acc Id:

XM_039097378 ⟹ XP_038953306

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	18	11,674,687 - 11,705,383 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_038953306	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

ENSRNOP00000030176 ⟸ ENSRNOT00000038635

RefSeq Acc Id:

ENSRNOP00000058060 ⟸ ENSRNOT00000061344

RefSeq Acc Id:

ENSRNOP00000022665 ⟸ ENSRNOT00000022665

RefSeq Acc Id:

XP_038953306 ⟸ XM_039097378

Protein Domains

Cadherin

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZM39-F1-model_v2	AlphaFold	D3ZM39	1-1060	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309925	AgrOrtholog
BioCyc Gene	G2FUF-8234	BioCyc
Ensembl Genes	ENSRNOG00000016853	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000058060	ENTREZGENE
	ENSRNOP00000058060.2	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000061344	ENTREZGENE
	ENSRNOT00000061344.5	UniProtKB/TrEMBL
Gene3D-CATH	4.10.900.10	UniProtKB/TrEMBL
	Cadherins	UniProtKB/TrEMBL
InterPro	Cadherin	UniProtKB/TrEMBL
	Cadherin-like	UniProtKB/TrEMBL
	Cadherin_CS	UniProtKB/TrEMBL
	Cadherin_cytoplasmic-dom	UniProtKB/TrEMBL
	Catenin_binding_dom	UniProtKB/TrEMBL
	Desmo_cadherin	UniProtKB/TrEMBL
NCBI Gene	291755	ENTREZGENE
PANTHER	DESMOGLEIN FAMILY MEMBER	UniProtKB/TrEMBL
	DESMOGLEIN-1	UniProtKB/TrEMBL
Pfam	Cadherin	UniProtKB/TrEMBL
	Cadherin_C	UniProtKB/TrEMBL
PharmGKB	DSG1	RGD
PhenoGen	Dsg1	PhenoGen
PRINTS	CADHERIN	UniProtKB/TrEMBL
	DESMOCADHERN	UniProtKB/TrEMBL
	DESMOGLEIN	UniProtKB/TrEMBL
PROSITE	CADHERIN_1	UniProtKB/TrEMBL
	CADHERIN_2	UniProtKB/TrEMBL
SMART	SM00112	UniProtKB/TrEMBL
Superfamily-SCOP	Cadherin	UniProtKB/TrEMBL
UniProt	D3ZM39_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-01-14	Dsg1	desmoglein 1	Dsg1b	desmoglein 1 beta	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-07-08	Dsg1b	desmoglein 1 beta	LOC679010	similar to Desmoglein-1 alpha precursor (Dsg1-alpha) (Desmoglein-1) (Desmosomal glycoprotein I) (DG1) (DGI)	Data Merged	1643240	APPROVED
2008-04-30	Dsg1b	desmoglein 1 beta	Dsg1b_predicted	desmoglein 1 beta (predicted)	'predicted' is removed	2292626	APPROVED
2006-11-20	LOC679010	similar to Desmoglein-1 alpha precursor (Dsg1-alpha) (Desmoglein-1) (Desmosomal glycoprotein I) (DG1) (DGI)			Symbol and Name status set to provisional	70820	PROVISIONAL
2005-01-12	Dsg1c_predicted	desmoglein 1 gamma (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)