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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2167
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Atp1a1
Name: ATPase Na+/K+ transporting subunit alpha 1
Acc ID: CHEBI:472805
Term: ouabain
Definition: A steroid hormone that is a multi-hydroxylated alpha-L-rhamnosyl cardenoloide. It binds to and inhibits the plasma membrane Na(+)/K(+)-ATPase (sodium pump). It has been isolated naturally from Strophanthus gratus.
Chemical ID: MESH:D010042
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atp1a1affects expressionEXP 6480464CTDOuabain affects the expression of ATP1A1 proteinPMID:11834625
Atp1a1increases expressionEXP 6480464CTDOuabain results in increased expression of ATP1A1 proteinPMID:11768735 PMID:16716361
Atp1a1affects bindingISOATP1A1 (Homo sapiens)6480464CTDOuabain binds to ATP1A1 proteinPMID:12479229
Atp1a1increases expressionISOATP1A1 (Homo sapiens)6480464CTDOuabain results in increased expression of ATP1A1 mRNA; Ouabain results in increased expression of ATP1A1 proteinPMID:19995221
Atp1a1multiple interactionsISOATP1A1 (Homo sapiens)6480464CTDLithium inhibits the reaction [Ouabain results in increased expression of ATP1A1 mRNA]; Lithium inhibits the reaction [Ouabain results in increased expression of ATP1A1 protein]PMID:19995221
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