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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hellebrigenin
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Accession:CHEBI:38344 term browser browse the term
Definition:A 19-oxo steroid that has formula C24H32O6.
Synonyms:exact_synonym: 3beta,5,14-trihydroxy-19-oxo-5beta-bufa-20,22-dienolide
 related_synonym: Bufotalidin;   Formula=C24H32O6;   Gellebrigenin;   InChI=1S/C24H32O6/c1-21-8-5-18-19(6-10-23(28)12-16(26)4-9-22(18,23)14-25)24(21,29)11-7-17(21)15-2-3-20(27)30-13-15/h2-3,13-14,16-19,26,28-29H,4-12H2,1H3/t16-,17+,18-,19?,21+,22-,23-,24-/m0/s1;   InChIKey=TVKPTWJPKVSGJB-IPTZTYHUSA-N;   SMILES=[H][C@]12CC[C@]3(C)[C@]([H])(CC[C@]3(O)C1CC[C@]1(O)C[C@@H](O)CC[C@]21C=O)c1ccc(=O)oc1
 xref: Beilstein:56259;   CAS:465-90-7;   KEGG:C16969
 xref_mesh: MESH:C001330


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hellebrigenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO hellebrigenin results in decreased phosphorylation of and results in decreased expression of AKT1 protein CTD PMID:24954031 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Atm ATM serine/threonine kinase increases phosphorylation ISO hellebrigenin results in increased phosphorylation of ATM protein CTD PMID:24954031 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects localization ISO hellebrigenin affects the localization of BAX protein CTD PMID:24954031 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Ccnb1 cyclin B1 increases expression ISO hellebrigenin results in increased expression of CCNB1 protein CTD PMID:24954031 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Cdc25c cell division cycle 25C decreases phosphorylation ISO hellebrigenin results in decreased phosphorylation of CDC25C protein CTD PMID:24954031 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases phosphorylation ISO hellebrigenin results in increased phosphorylation of CDK1 protein CTD PMID:24954031 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Chek2 checkpoint kinase 2 increases phosphorylation ISO hellebrigenin results in increased phosphorylation of CHEK2 protein CTD PMID:24954031 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases activity ISO hellebrigenin results in increased activity of PARP1 protein CTD PMID:24954031 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19801
    role 19747
      application 19395
        solvent 16478
          formic acid 7882
            formyl group 7848
              aldehyde 7848
                steroid aldehyde 91
                  hellebrigenin 8
                    hellebrin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19801
    subatomic particle 19797
      composite particle 19797
        hadron 19797
          baryon 19797
            nucleon 19797
              atomic nucleus 19797
                atom 19797
                  main group element atom 19684
                    p-block element atom 19684
                      carbon group element atom 19583
                        carbon atom 19572
                          organic molecular entity 19572
                            organic group 18520
                              organic divalent group 18513
                                organodiyl group 18513
                                  carbonyl group 18415
                                    carbonyl compound 18415
                                      carboxylic acid 18087
                                        carboacyl group 17374
                                          univalent carboacyl group 17374
                                            formyl group 7848
                                              aldehyde 7848
                                                steroid aldehyde 91
                                                  hellebrigenin 8
                                                    hellebrin 0
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