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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:ouabain
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Accession:CHEBI:472805 term browser browse the term
Definition:A steroid hormone that is a multi-hydroxylated alpha-L-rhamnosyl cardenoloide. It binds to and inhibits the plasma membrane Na(+)/K(+)-ATPase (sodium pump). It has been isolated naturally from Strophanthus gratus.
Synonyms:exact_synonym: 3-(6-deoxy-alpha-L-mannopyranosyloxy)-1beta,5beta,11alpha,14,19-pentahydroxy-5beta-card-20(22)-enolide
 related_synonym: 3-(alpha-L-rhamnopyranosyloxy)-1beta,5beta,11alpha,14,19-pentahydroxy-5beta-card-20(22)-enolide;   Formula=C29H44O12;   G-Strophanthin;   InChI=1S/C29H44O12/c1-13-22(34)23(35)24(36)25(40-13)41-15-8-19(32)28(12-30)21-17(3-5-27(28,37)9-15)29(38)6-4-16(14-7-20(33)39-11-14)26(29,2)10-18(21)31/h7,13,15-19,21-25,30-32,34-38H,3-6,8-12H2,1-2H3/t13-,15-,16+,17+,18+,19+,21+,22-,23+,24+,25-,26+,27-,28+,29-/m0/s1;   InChIKey=LPMXVESGRSUGHW-HBYQJFLCSA-N;   Ouabagenin L-Rhamnoside;   Ouabagenin-L-rhamnosid;   Ouabain anhydrous;   Ouabaine;   Oubain;   SMILES=[H][C@@]12CC[C@]3(O)C[C@H](C[C@@H](O)[C@]3(CO)[C@@]1([H])[C@H](O)C[C@]1(C)[C@H](CC[C@]21O)C1=CC(=O)OC1)O[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O;   Strodival
 alt_id: CHEBI:44461;   CHEBI:7805
 xref: Beilstein:101712;   CAS:630-60-4;   DrugBank:DB01092;   Drug_Central:2004;   FooDB:FDB005482;   HMDB:HMDB0015224;   KEGG:C01443;   KEGG:D00112;   KNApSAcK:C00003633;   LINCS:LSM-2781;   LIPID_MAPS_instance:LMST01120022
 xref_mesh: MESH:D010042
 xref: PDBeChem:OBN;   PMID:10438974;   PMID:1316269;   PMID:16529963;   PMID:20372980;   PMID:31075189;   PMID:31170971;   PMID:31548455;   PMID:31986323;   PMID:32326025;   PMID:32368275;   PMID:32488807;   PMID:32569558;   PMID:9872395;   Reaxys:101712;   Wikipedia:Ouabain
 cyclic_relationship: is_conjugate_acid_of CHEBI:145798


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ouabain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin affects expression ISO Ouabain affects the expression of A2M protein CTD PMID:17268060 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression
ISO 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Ouabain results in increased expression of ABCB1 protein]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Ouabain results in increased expression of ABCB1 mRNA]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Ouabain results in increased expression of ABCB1 protein]; [Ouabain results in increased expression of ABCB1] which results in decreased susceptibility to Doxorubicin; KN 93 inhibits the reaction [Ouabain results in increased expression of ABCB1 protein]
Ouabain results in increased expression of ABCB1 mRNA; Ouabain results in increased expression of ABCB1 protein
CTD PMID:19647009 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Acaa2 acetyl-CoA acyltransferase 2 affects expression ISO Ouabain affects the expression of ACAA2 protein CTD PMID:17268060 NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249
JBrowse link
G Ace angiotensin I converting enzyme affects expression EXP Ouabain affects the expression of ACE mRNA; Ouabain affects the expression of ACE protein CTD PMID:16565308 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Acta2 actin alpha 2, smooth muscle affects expression ISO Ouabain affects the expression of ACTA2 protein CTD PMID:17268060 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Adh1 alcohol dehydrogenase 1 (class I) affects expression ISO Ouabain affects the expression of ADH1C protein CTD PMID:17268060 NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892
JBrowse link
G Agt angiotensinogen affects expression
increases expression
EXP Ouabain affects the expression of AGT protein
Ouabain results in increased expression of AGT protein
CTD PMID:11768735 PMID:16565308 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Agtr1a angiotensin II receptor, type 1a decreases expression
affects expression
EXP Ouabain results in decreased expression of AGTR1A protein
Ouabain affects the expression of AGTR1A mRNA
CTD PMID:16565308 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression ISO Ouabain results in increased expression of AIFM1 protein CTD PMID:31436044 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256
JBrowse link
G Anxa1 annexin A1 affects expression ISO Ouabain affects the expression of ANXA1 protein CTD PMID:17268060 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
JBrowse link
G Anxa2 annexin A2 affects expression ISO Ouabain affects the expression of ANXA2 protein CTD PMID:17268060 NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO Ouabain results in increased expression of APAF1 protein CTD PMID:31436044 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
JBrowse link
G Araf A-Raf proto-oncogene, serine/threonine kinase decreases expression ISO Ouabain results in decreased expression of ARAF mRNA CTD PMID:16412265 NCBI chr  X:1,227,392...1,292,356
Ensembl chr  X:1,227,392...1,239,073
JBrowse link
G Arih1 ariadne RBR E3 ubiquitin protein ligase 1 decreases expression ISO Ouabain results in decreased expression of ARIH1 mRNA CTD PMID:16412265 NCBI chr 8:59,777,378...59,879,762
Ensembl chr 8:59,777,379...59,880,245
JBrowse link
G Arpc5 actin related protein 2/3 complex, subunit 5 affects expression ISO Ouabain affects the expression of ARPC5 protein CTD PMID:17268060 NCBI chr13:64,904,504...64,913,413
Ensembl chr13:64,887,136...64,913,410
JBrowse link
G Arrb1 arrestin, beta 1 increases expression ISO Ouabain results in increased expression of ARRB1 mRNA CTD PMID:16412265 NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061
JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 affects expression ISO Ouabain affects the expression of ASAH1 protein CTD PMID:17268060 NCBI chr16:50,966,404...50,997,827
Ensembl chr16:50,966,229...51,008,233
JBrowse link
G Atf6b activating transcription factor 6 beta increases expression ISO Ouabain results in increased expression of ATF6B protein CTD PMID:31436044 NCBI chr20:4,090,921...4,098,920
Ensembl chr20:4,090,921...4,098,894
JBrowse link
G Atm ATM serine/threonine kinase increases phosphorylation ISO Ouabain results in increased phosphorylation of ATM protein CTD PMID:31436044 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Atp12a ATPase H+/K+ transporting non-gastric alpha2 subunit multiple interactions ISO Ouabain inhibits the reaction [[ATP12A protein co-treated with ATP4B protein] results in increased uptake of Rubidium] CTD PMID:8853415 NCBI chr15:30,443,571...30,468,229
Ensembl chr15:30,443,571...30,468,229
JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 multiple interactions
increases expression
affects expression
affects binding
ISO
EXP
Lithium inhibits the reaction [Ouabain results in increased expression of ATP1A1 mRNA]; Lithium inhibits the reaction [Ouabain results in increased expression of ATP1A1 protein]
Ouabain affects the expression of ATP1A1 protein
Ouabain results in increased expression of ATP1A1 mRNA; Ouabain results in increased expression of ATP1A1 protein
Ouabain binds to ATP1A1 protein
CTD PMID:11768735 PMID:11834625 PMID:12479229 PMID:16716361 PMID:19995221 NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837
JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 multiple interactions
increases expression
decreases expression
affects expression
decreases activity
affects response to substance
affects binding
ISO
EXP
Lithium inhibits the reaction [Ouabain results in increased expression of ATP1A2 mRNA]
Ouabain results in increased expression of ATP1A2 protein
Ouabain results in decreased expression of ATP1A2 mRNA
Ouabain affects the expression of ATP1A2 protein
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in decreased expression of ATP1A2 mRNA]
Ouabain results in decreased activity of ATP1A2 protein
Ouabain binds to and results in decreased activity of ATP1A2 protein
ATP1A2 protein affects the susceptibility to Ouabain
Ouabain binds to ATP1A2 protein
CTD PMID:11834625 PMID:12479229 PMID:15458945 PMID:16166162 PMID:16716361 More... NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544
JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 increases expression
multiple interactions
decreases expression
affects expression
affects binding
ISO
EXP
Ouabain results in increased expression of ATP1A3 mRNA; Ouabain results in increased expression of ATP1A3 protein
Potassium Chloride inhibits the reaction [ATP1A3 protein binds to Ouabain]
Ouabain results in decreased expression of ATP1A3 mRNA
Ouabain affects the expression of ATP1A3 protein
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in decreased expression of ATP1A3 mRNA]
ATP1A3 protein binds to Ouabain; Ouabain binds to ATP1A3 protein
CTD PMID:11204457 PMID:12479229 PMID:15276875 PMID:19687166 PMID:19995221 More... NCBI chr 1:80,572,790...80,601,936
Ensembl chr 1:80,572,796...80,601,918
JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 multiple interactions
increases expression
EXP 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Ouabain results in increased expression of ATP1B1 mRNA]; Calcium affects the reaction [Ouabain results in increased expression of ATP1B1 mRNA]; W 7 inhibits the reaction [Ouabain results in increased expression of ATP1B1 mRNA] CTD PMID:11204457 NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459
JBrowse link
G Atp4b ATPase H+/K+ transporting subunit beta multiple interactions ISO Ouabain inhibits the reaction [[ATP12A protein co-treated with ATP4B protein] results in increased uptake of Rubidium] CTD PMID:8853415 NCBI chr16:76,144,150...76,153,063
Ensembl chr16:76,144,150...76,153,063
JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha affects expression ISO Ouabain affects the expression of ATP5F1A protein CTD PMID:17268060 NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794
JBrowse link
G Atr ATR serine/threonine kinase decreases phosphorylation ISO Ouabain results in decreased phosphorylation of ATR protein CTD PMID:31436044 NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136
JBrowse link
G Bahd1 bromo adjacent homology domain containing 1 decreases expression ISO Ouabain results in decreased expression of BAHD1 mRNA CTD PMID:16412265 NCBI chr 3:105,891,207...105,914,414
Ensembl chr 3:105,892,478...105,914,410
JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects localization
increases expression
multiple interactions
ISO Ouabain affects the localization of BAX protein
Ouabain results in increased expression of BAX protein
Ouabain inhibits the reaction [HSPD1 protein binds to BAX protein]
CTD PMID:17096883 PMID:18247327 PMID:31436044 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Ouabain results in decreased expression of BCL2 protein CTD PMID:31436044 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO Ouabain results in decreased expression of BCL2L1 protein CTD PMID:31436044 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions
decreases expression
EXP Lithium inhibits the reaction [Ouabain results in decreased expression of BDNF protein] CTD PMID:19954800 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Brca1 BRCA1, DNA repair associated decreases expression ISO Ouabain results in decreased expression of BRCA1 protein CTD PMID:31436044 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
JBrowse link
G Calb1 calbindin 1 decreases expression EXP Ouabain results in decreased expression of CALB1 protein CTD PMID:20105455 NCBI chr 5:29,375,624...29,402,532
Ensembl chr 5:29,375,642...29,402,431
JBrowse link
G Calml5 calmodulin-like 5 affects expression ISO Ouabain affects the expression of CALML5 protein CTD PMID:17268060 NCBI chr17:66,394,433...66,395,390 JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta increases expression ISO Ouabain results in increased expression of CAMK2B protein CTD PMID:31436044 NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994
JBrowse link
G Canx calnexin increases expression ISO Ouabain results in increased expression of CANX protein CTD PMID:18247327 NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821
JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions
increases activity
ISO
EXP
Ouabain results in increased expression of CASP3 protein
Ouabain results in increased activity of and results in increased cleavage of CASP3 protein
Ouabain results in increased activity of CASP3 protein
CTD PMID:11435898 PMID:17096883 PMID:18247327 PMID:20435043 PMID:31436044 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp4 caspase 4 increases expression ISO Ouabain results in increased expression of CASP4 protein CTD PMID:31436044 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
JBrowse link
G Casp8 caspase 8 multiple interactions ISO Ouabain results in increased expression of and results in increased activity of CASP8 protein CTD PMID:31436044 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Ouabain results in increased expression of and results in increased activity of CASP9 protein CTD PMID:31436044 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions
decreases activity
EXP Lithium inhibits the reaction [Ouabain results in decreased activity of CAT protein]; Valproic Acid inhibits the reaction [Ouabain results in decreased activity of CAT protein] CTD PMID:20627318 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cav1 caveolin 1 decreases expression ISO Ouabain results in decreased expression of CAV1 mRNA CTD PMID:28795476 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
JBrowse link
G Ccdc14 coiled-coil domain containing 14 decreases expression ISO Ouabain results in decreased expression of CCDC14 mRNA CTD PMID:16412265 NCBI chr11:66,052,063...66,087,915
Ensembl chr11:66,052,620...66,087,956
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression
EXP 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Ouabain results in increased expression of CCL2 mRNA]; Amiloride inhibits the reaction [Ouabain results in increased expression of CCL2 protein]; Sodium deficiency inhibits the reaction [Ouabain results in increased expression of CCL2 mRNA]; Sodium deficiency inhibits the reaction [Ouabain results in increased expression of CCL2 protein]
Ouabain results in increased expression of CCL2 mRNA; Ouabain results in increased expression of CCL2 protein
CTD PMID:11340305 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccna1 cyclin A1 decreases expression ISO Ouabain results in decreased expression of CCNA1 mRNA CTD PMID:20460749 NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO Ouabain results in decreased expression of CCNA2 mRNA CTD PMID:21215801 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Ouabain results in decreased expression of CCND1 mRNA CTD PMID:28795476 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdh1 cadherin 1 decreases expression
increases expression
ISO Ouabain results in decreased expression of CDH1 protein
Ouabain results in increased expression of CDH1 mRNA
CTD PMID:28795476 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdh2 cadherin 2 decreases expression ISO Ouabain results in decreased expression of CDH2 mRNA; Ouabain results in decreased expression of CDH2 protein CTD PMID:28795476 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO Ouabain results in decreased expression of CDK2 mRNA; Ouabain results in decreased expression of CDK2 protein CTD PMID:20460749 PMID:21215801 PMID:31436044 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk6 cyclin-dependent kinase 6 decreases expression ISO Ouabain results in decreased expression of CDK6 protein CTD PMID:31436044 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression
increases expression
ISO Ouabain results in decreased expression of CDKN1A mRNA; Ouabain results in decreased expression of CDKN1A protein
Ouabain results in increased expression of CDKN1A mRNA; Ouabain results in increased expression of CDKN1A protein
CTD PMID:20460749 PMID:21215801 PMID:28795476 PMID:31436044 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Ckb creatine kinase B decreases activity EXP Ouabain results in decreased activity of CKB protein CTD PMID:19911114 NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315
JBrowse link
G Cldn1 claudin 1 decreases expression ISO Ouabain results in decreased expression of CLDN1 protein CTD PMID:18247327 NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724
JBrowse link
G Cnpy2 canopy FGF signaling regulator 2 affects expression ISO Ouabain affects the expression of CNPY2 protein CTD PMID:17268060 NCBI chr 7:748,877...754,352
Ensembl chr 7:749,008...755,519
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
increases expression
EXP MIR29B1 mRNA inhibits the reaction [Ouabain results in increased expression of COL1A1 mRNA] CTD PMID:26702050 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Cs citrate synthase decreases activity EXP Ouabain results in decreased activity of CS protein CTD PMID:20372980 NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421
JBrowse link
G Cyc1 cytochrome c-1 multiple interactions ISO Ouabain results in decreased expression of and affects the localization of CYC1 protein CTD PMID:18247327 NCBI chr 7:108,067,106...108,069,483
Ensembl chr 7:108,067,115...108,069,479
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Ouabain results in increased expression of DDIT3 protein CTD PMID:31436044 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Ddost dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit decreases expression ISO Ouabain results in decreased expression of DDOST mRNA CTD PMID:16412265 NCBI chr 5:150,522,297...150,529,413
Ensembl chr 5:150,522,242...150,529,413
JBrowse link
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 increases expression ISO Ouabain results in increased expression of DNAJA3 mRNA CTD PMID:28795476 NCBI chr10:10,855,510...10,880,175
Ensembl chr10:10,854,732...10,880,161
JBrowse link
G Drd1 dopamine receptor D1 multiple interactions
decreases expression
ISO
EXP
Ouabain results in decreased expression of and results in increased phosphorylation of DRD1 protein
Ouabain results in increased phosphorylation of and results in decreased expression of DRD1 protein
Ouabain results in decreased expression of DRD1 mRNA
CTD PMID:19626329 PMID:20132239 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
JBrowse link
G Dsg1 desmoglein 1 affects expression ISO Ouabain affects the expression of DSG1 protein CTD PMID:17268060 NCBI chr18:11,674,687...11,705,383
Ensembl chr18:11,674,402...11,703,443
JBrowse link
G Dut deoxyuridine triphosphatase affects expression ISO Ouabain affects the expression of DUT protein CTD PMID:17268060 NCBI chr 3:112,498,864...112,509,994
Ensembl chr 3:112,498,982...112,510,771
JBrowse link
G Ece1 endothelin converting enzyme 1 increases expression ISO Ouabain results in increased expression of ECE1 protein CTD PMID:18247327 NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371
JBrowse link
G Echs1 enoyl-CoA hydratase, short chain 1 affects expression ISO Ouabain affects the expression of ECHS1 protein CTD PMID:17268060 NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884
JBrowse link
G Edn1 endothelin 1 increases expression
decreases expression
EXP
ISO
Ouabain results in increased expression of EDN1 mRNA
Ouabain results in decreased expression of EDN1 mRNA
CTD PMID:15477225 PMID:28795476 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Ednra endothelin receptor type A increases expression EXP Ouabain results in increased expression of EDNRA mRNA; Ouabain results in increased expression of EDNRA protein CTD PMID:15477225 PMID:16982439 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049
JBrowse link
G Egfr epidermal growth factor receptor decreases phosphorylation ISO Ouabain results in decreased phosphorylation of EGFR protein CTD PMID:28795476 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases expression ISO Ouabain results in increased expression of EIF2A protein CTD PMID:31436044 NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO Ouabain results in increased expression of and results in increased phosphorylation of EIF2AK3 protein CTD PMID:31436044 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Eif3k eukaryotic translation initiation factor 3, subunit K affects expression ISO Ouabain affects the expression of EIF3K protein CTD PMID:17268060 NCBI chr 1:84,260,125...84,270,051
Ensembl chr 1:84,259,673...84,270,302
JBrowse link
G Endog endonuclease G increases expression ISO Ouabain results in increased expression of ENDOG protein CTD PMID:31436044 NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932
JBrowse link
G Ercc4 ERCC excision repair 4, endonuclease catalytic subunit decreases expression ISO Ouabain results in decreased expression of ERCC4 mRNA CTD PMID:24124520 NCBI chr10:2,416,259...2,448,364 JBrowse link
G Ets1 ETS proto-oncogene 1, transcription factor decreases expression ISO Ouabain results in decreased expression of ETS1 mRNA CTD PMID:28795476 NCBI chr 8:31,045,909...31,168,010
Ensembl chr 8:31,045,945...31,168,010
JBrowse link
G Fadd Fas associated via death domain increases expression ISO Ouabain results in increased expression of FADD protein CTD PMID:31436044 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
JBrowse link
G Fancd2 FA complementation group D2 multiple interactions
decreases expression
ISO Ouabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]; SB 203580 inhibits the reaction [Ouabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCD2 protein]]
Ouabain results in decreased expression of FANCD2 mRNA
CTD PMID:24124520 NCBI chr 4:146,679,014...146,743,422
Ensembl chr 4:146,679,179...146,743,412
JBrowse link
G Fancf FA complementation group F decreases expression ISO Ouabain results in decreased expression of FANCF mRNA CTD PMID:24124520 NCBI chr 1:101,449,120...101,452,361
Ensembl chr 1:101,450,389...101,451,923
JBrowse link
G Fanci FA complementation group I decreases expression
multiple interactions
ISO Ouabain results in decreased expression of FANCI mRNA
Ouabain inhibits the reaction [Mitomycin results in increased expression of and affects the ubiquitination of FANCI protein]
CTD PMID:24124520 NCBI chr 1:133,327,264...133,383,661
Ensembl chr 1:133,327,297...133,383,640
JBrowse link
G Fars2 phenylalanyl-tRNA synthetase 2, mitochondrial increases expression ISO Ouabain results in increased expression of FARS2 mRNA CTD PMID:16412265 NCBI chr17:28,319,215...28,746,217
Ensembl chr17:28,319,280...28,746,337
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO Ouabain results in increased expression of FAS protein CTD PMID:31436044 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand increases expression ISO Ouabain results in increased expression of FASLG protein CTD PMID:31436044 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fbxo32 F-box protein 32 multiple interactions ISO Ouabain affects the reaction [Botulinum Toxins, Type A affects the expression of FBXO32 mRNA] CTD PMID:21139329 NCBI chr 7:89,731,626...89,764,761
Ensembl chr 7:89,730,232...89,765,436
JBrowse link
G Fh fumarate hydratase affects expression ISO Ouabain affects the expression of FH protein CTD PMID:17268060 NCBI chr13:87,524,331...87,550,215
Ensembl chr13:87,524,337...87,550,266
JBrowse link
G Fkbp7 FKBP prolyl isomerase 7 increases expression ISO Ouabain results in increased expression of FKBP7 mRNA CTD PMID:16412265 NCBI chr 3:61,609,384...61,623,710
Ensembl chr 3:61,608,557...61,623,280
JBrowse link
G Fn1 fibronectin 1 decreases expression ISO Ouabain results in decreased expression of FN1 mRNA CTD PMID:28795476 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Gc GC, vitamin D binding protein affects expression ISO Ouabain affects the expression of GC protein CTD PMID:17268060 NCBI chr14:18,632,146...18,667,563
Ensembl chr14:18,632,135...18,667,567
JBrowse link
G Glrb glycine receptor, beta increases expression ISO Ouabain results in increased expression of GLRB mRNA CTD PMID:16412265 NCBI chr 2:166,134,624...166,207,509
Ensembl chr 2:166,134,626...166,207,489
JBrowse link
G Grb2 growth factor receptor bound protein 2 decreases expression ISO Ouabain results in decreased expression of GRB2 protein CTD PMID:28795476 NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309
JBrowse link
G Gtpbp6 GTP binding protein 6 (putative) increases expression ISO Ouabain results in increased expression of GTPBP6 mRNA CTD PMID:16412265 NCBI chr12:46,574,913...46,578,873
Ensembl chr12:46,574,435...46,578,873
JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 increases expression ISO Ouabain results in increased expression of HEY1 mRNA CTD PMID:28795476 NCBI chr 2:93,096,706...93,100,316
Ensembl chr 2:93,095,498...93,100,312
JBrowse link
G Hgf hepatocyte growth factor multiple interactions EXP Ouabain inhibits the reaction [HGF protein results in increased uptake of estradiol-17 beta-glucuronide] CTD PMID:18031729 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
affects localization
increases activity
ISO 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Ouabain affects the localization of HIF1A protein]; 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [Ouabain results in increased phosphorylation of HIF1A protein]; 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [Ouabain affects the localization of HIF1A protein]; KN 93 inhibits the reaction [Ouabain affects the localization of HIF1A protein]; KN 93 inhibits the reaction [Ouabain results in increased phosphorylation of HIF1A protein]; Ouabain results in increased phosphorylation of and results in increased expression of HIF1A protein
Ouabain results in increased activity of HIF1A protein
CTD PMID:19647009 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 affects expression ISO Ouabain affects the expression of HNRNPA2B1 protein CTD PMID:17268060 NCBI chr 4:80,534,659...80,545,297
Ensembl chr 4:80,534,651...80,545,249
JBrowse link
G Hnrnpdl heterogeneous nuclear ribonucleoprotein D-like decreases expression ISO Ouabain results in decreased expression of HNRNPDL mRNA CTD PMID:16412265 NCBI chr14:9,558,079...9,563,654
Ensembl chr14:9,557,425...9,562,506
JBrowse link
G Hpcal1 hippocalcin-like 1 affects expression ISO Ouabain affects the expression of HPCAL1 protein CTD PMID:17268060 NCBI chr 6:40,478,182...40,584,721
Ensembl chr 6:40,478,208...40,584,687
JBrowse link
G Hrg histidine-rich glycoprotein affects expression ISO Ouabain affects the expression of HRG protein CTD PMID:17268060 NCBI chr11:78,054,488...78,069,402
Ensembl chr11:78,054,498...78,069,389
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO Ouabain results in increased expression of HSPA5 protein CTD PMID:31436044 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 affects expression
multiple interactions
ISO Ouabain affects the expression of HSPD1 protein
Ouabain inhibits the reaction [HSPD1 protein binds to BAX protein]; Ouabain results in decreased expression of and affects the localization of HSPD1 protein
CTD PMID:17268060 PMID:18247327 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
JBrowse link
G Id2 inhibitor of DNA binding 2 increases expression ISO Ouabain results in increased expression of ID2 mRNA CTD PMID:28795476 NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha decreases expression ISO Ouabain results in decreased expression of IL2RA mRNA CTD PMID:7593202 NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697
JBrowse link
G Il2rb interleukin 2 receptor subunit beta decreases expression ISO Ouabain results in decreased expression of IL2RB CTD PMID:7593202 NCBI chr 7:110,033,341...110,048,054
Ensembl chr 7:110,033,341...110,048,054
JBrowse link
G Il6 interleukin 6 increases secretion
increases expression
ISO Ouabain results in increased secretion of IL6 protein
Ouabain results in increased expression of IL6 mRNA
CTD PMID:33760381 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Il6r interleukin 6 receptor increases expression ISO Ouabain results in increased expression of IL6R mRNA CTD PMID:33760381 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
JBrowse link
G Ilk integrin-linked kinase decreases expression ISO Ouabain results in decreased expression of ILK mRNA CTD PMID:28795476 NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140
JBrowse link
G Itgav integrin subunit alpha V decreases expression ISO Ouabain results in decreased expression of ITGAV mRNA CTD PMID:28795476 NCBI chr 3:68,838,524...68,926,653
Ensembl chr 3:68,838,189...68,926,639
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression
decreases phosphorylation
ISO Ouabain results in decreased expression of JUN mRNA
Ouabain results in decreased phosphorylation of JUN protein
CTD PMID:28795476 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Kcnd2 potassium voltage-gated channel subfamily D member 2 increases expression ISO
EXP
Ouabain results in increased expression of KCND2 mRNA CTD PMID:16412265 NCBI chr 4:49,775,812...50,277,746
Ensembl chr 4:49,776,246...50,277,728
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases expression
decreases activity
multiple interactions
ISO Ouabain results in decreased expression of KCNH2 protein modified form
Ouabain results in decreased activity of KCNH2 protein
Ouabain inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
CTD PMID:19139152 PMID:21158687 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Lef1 lymphoid enhancer binding factor 1 decreases expression ISO Ouabain results in decreased expression of LEF1 mRNA CTD PMID:28795476 NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794
JBrowse link
G Lgals1 galectin 1 affects expression
increases expression
ISO Ouabain affects the expression of LGALS1 protein
Ouabain results in increased expression of LGALS1 protein
CTD PMID:17268060 PMID:18247327 NCBI chr 7:110,485,239...110,488,345
Ensembl chr 7:110,481,392...110,488,345
JBrowse link
G Limk1 LIM domain kinase 1 decreases expression ISO Ouabain results in decreased expression of LIMK1 mRNA CTD PMID:28795476 NCBI chr12:22,026,697...22,060,605
Ensembl chr12:22,026,672...22,060,606
JBrowse link
G Lss lanosterol synthase increases abundance ISO LSS protein results in increased abundance of Ouabain CTD PMID:21106941 NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762
JBrowse link
G Map2k6 mitogen-activated protein kinase kinase 6 increases expression ISO Ouabain results in increased expression of MAP2K6 mRNA CTD PMID:28795476 NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
increases phosphorylation
EXP
ISO
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased phosphorylation of MAPK1 protein]
Ouabain results in decreased phosphorylation of MAPK1 protein
CTD PMID:19687166 PMID:28795476 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
increases phosphorylation
EXP
ISO
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased phosphorylation of MAPK3 protein]
Ouabain results in decreased phosphorylation of MAPK3 protein
CTD PMID:19687166 PMID:28795476 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk7 mitogen-activated protein kinase 7 multiple interactions ISO Ouabain inhibits the reaction [palytoxin results in increased phosphorylation of and results in increased activity of MAPK7 protein] CTD PMID:19716839 NCBI chr10:46,170,264...46,176,262
Ensembl chr10:46,170,167...46,176,267
JBrowse link
G Mdh2 malate dehydrogenase 2 affects expression ISO Ouabain affects the expression of MDH2 protein CTD PMID:17268060 NCBI chr12:20,894,269...20,907,225
Ensembl chr12:20,894,262...20,907,271
JBrowse link
G Mdm2 MDM2 proto-oncogene multiple interactions ISO Ouabain results in decreased expression of and results in decreased phosphorylation of MDM2 protein CTD PMID:31436044 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases expression ISO Ouabain results in decreased expression of MGMT protein CTD PMID:31436044 NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
JBrowse link
G Mir29b1 microRNA 29b-1 multiple interactions
decreases expression
EXP MIR29B1 mRNA inhibits the reaction [Ouabain results in increased expression of COL1A1 mRNA]
Ouabain results in decreased expression of MIR29B1 mRNA
CTD PMID:26702050 NCBI chr 4:59,650,987...59,651,067
Ensembl chr 4:59,650,986...59,651,067
JBrowse link
G Mmp13 matrix metallopeptidase 13 decreases expression ISO Ouabain results in decreased expression of MMP13 mRNA CTD PMID:28795476 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression
multiple interactions
ISO Ouabain results in decreased expression of MMP2 mRNA
Ouabain results in decreased expression of and results in decreased activity of MMP2 protein
CTD PMID:28795476 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO Ouabain results in decreased expression of MMP9 mRNA; Ouabain results in decreased expression of MMP9 protein CTD PMID:28795476 PMID:33760381 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mras muscle RAS oncogene homolog decreases expression ISO Ouabain results in decreased expression of MRAS mRNA CTD PMID:28795476 NCBI chr 8:99,944,036...100,006,771
Ensembl chr 8:99,944,036...99,996,408
JBrowse link
G Mrtfa myocardin related transcription factor A decreases expression ISO Ouabain results in decreased expression of MRTFA mRNA CTD PMID:28795476 NCBI chr 7:112,544,312...112,714,431
Ensembl chr 7:112,544,312...112,714,418
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression
increases expression
ISO Ouabain results in decreased expression of MYC mRNA; Ouabain results in decreased expression of MYC protein
Ouabain results in increased expression of MYC protein
CTD PMID:9653513 PMID:21215801 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Myl12a myosin light chain 12A increases expression ISO Ouabain results in increased expression of MYL12A protein CTD PMID:17268060 NCBI chr 9:110,891,970...110,899,655
Ensembl chr 9:110,873,959...110,916,580
JBrowse link
G Mylk myosin light chain kinase decreases expression ISO Ouabain results in decreased expression of MYLK mRNA CTD PMID:28795476 NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261
JBrowse link
G Nectin3 nectin cell adhesion molecule 3 decreases expression ISO Ouabain results in decreased expression of NECTIN3 mRNA CTD PMID:28795476 NCBI chr11:54,362,712...54,461,316
Ensembl chr11:54,364,487...54,462,519
JBrowse link
G Nectin4 nectin cell adhesion molecule 4 increases expression ISO Ouabain results in increased expression of NECTIN4 mRNA CTD PMID:28795476 NCBI chr13:83,802,589...83,821,711
Ensembl chr13:83,803,184...83,821,709
JBrowse link
G Nefl neurofilament light chain decreases expression ISO Ouabain results in decreased expression of NEFL mRNA CTD PMID:28795476 NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793
JBrowse link
G Nos1 nitric oxide synthase 1 affects expression
increases expression
EXP Ouabain affects the expression of NOS1 protein
Ouabain results in increased expression of NOS1 protein
CTD PMID:12384489 PMID:15097235 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
affects expression
increases expression
EXP 5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide inhibits the reaction [Ouabain results in increased expression of NOS3 protein]
Ouabain affects the expression of NOS3 protein
CTD PMID:12384489 PMID:15477225 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Npc2 NPC intracellular cholesterol transporter 2 decreases expression ISO Ouabain results in decreased expression of NPC2 mRNA CTD PMID:16412265 NCBI chr 6:104,397,239...104,418,161
Ensembl chr 6:104,378,644...104,418,155
JBrowse link
G Nppa natriuretic peptide A increases expression
multiple interactions
EXP Ouabain results in increased expression of NPPA mRNA
N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased expression of NPPA mRNA]; Ouabain promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA]
CTD PMID:17266992 PMID:19687166 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Nras NRAS proto-oncogene, GTPase decreases expression ISO Ouabain results in decreased expression of NRAS mRNA CTD PMID:28795476 NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626
JBrowse link
G Park7 Parkinsonism associated deglycase affects response to substance ISO PARK7 affects the susceptibility to Ouabain CTD PMID:16624565 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
ISO Mitomycin promotes the reaction [Ouabain results in increased cleavage of PARP1 protein]; Ouabain promotes the reaction [Mitomycin results in increased cleavage of PARP1 protein] CTD PMID:24124520 PMID:31436044 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO Ouabain results in decreased expression of PCNA mRNA; Ouabain results in decreased expression of PCNA protein CTD PMID:20460749 PMID:21215801 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pdcd6 programmed cell death 6 increases expression ISO Ouabain results in increased expression of PDCD6 protein CTD PMID:18247327 NCBI chr 1:28,966,518...28,982,188
Ensembl chr 1:28,966,518...28,982,189
JBrowse link
G Pfdn5 prefoldin subunit 5 affects expression ISO Ouabain affects the expression of PFDN5 protein CTD PMID:17268060 NCBI chr 7:133,451,778...133,456,516
Ensembl chr 7:133,451,453...133,456,516
JBrowse link
G Pfn1 profilin 1 affects expression
decreases expression
ISO Ouabain affects the expression of PFN1 protein
Ouabain results in decreased expression of PFN1 protein
CTD PMID:17268060 PMID:18247327 NCBI chr10:55,365,263...55,367,968
Ensembl chr10:55,365,262...55,527,631
JBrowse link
G Plaur plasminogen activator, urokinase receptor decreases expression ISO Ouabain results in decreased expression of PLAUR mRNA CTD PMID:28795476 NCBI chr 1:80,053,441...80,068,384
Ensembl chr 1:80,050,324...80,068,595
JBrowse link
G Plcg1 phospholipase C, gamma 1 decreases expression ISO Ouabain results in decreased expression of PLCG1 mRNA CTD PMID:28795476 NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330
JBrowse link
G Ppt2 palmitoyl-protein thioesterase 2 decreases expression ISO Ouabain results in decreased expression of PPT2 mRNA CTD PMID:16412265 NCBI chr20:4,112,520...4,132,774
Ensembl chr20:4,122,463...4,132,774
JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit decreases expression ISO Ouabain results in decreased expression of PRKDC protein CTD PMID:31436044 NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952
JBrowse link
G Psmb6 proteasome 20S subunit beta 6 affects expression ISO Ouabain affects the expression of PSMB6 protein CTD PMID:17268060 NCBI chr10:55,239,274...55,241,581
Ensembl chr10:55,239,241...55,241,586
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
EXP [Ouabain results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Nitric Oxide CTD PMID:18976649 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 decreases expression ISO Ouabain results in decreased expression of PTPN2 mRNA CTD PMID:16412265 NCBI chr18:61,229,012...61,294,662
Ensembl chr18:61,229,014...61,294,627
JBrowse link
G Rab11b RAB11B, member RAS oncogene family increases expression ISO Ouabain results in increased expression of RAB11B protein CTD PMID:18247327 NCBI chr 7:14,521,448...14,534,589
Ensembl chr 7:14,521,368...14,534,593
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase decreases expression ISO Ouabain results in decreased expression of RAF1 mRNA CTD PMID:28795476 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Rasgrf1 RAS protein-specific guanine nucleotide-releasing factor 1 decreases expression ISO Ouabain results in decreased expression of RASGRF1 mRNA CTD PMID:28795476 NCBI chr 8:90,445,154...90,574,274
Ensembl chr 8:90,445,154...90,574,269
JBrowse link
G Rgs2 regulator of G-protein signaling 2 decreases expression ISO Ouabain results in decreased expression of RGS2 mRNA CTD PMID:28795476 NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385
JBrowse link
G Rhoh ras homolog family member H increases expression ISO Ouabain results in increased expression of RHOH mRNA CTD PMID:28795476 NCBI chr14:42,341,135...42,371,971
Ensembl chr14:42,337,751...42,386,369
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 increases cleavage
multiple interactions
ISO Ouabain results in increased cleavage of ROCK1 protein
benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [Ouabain results in increased cleavage of ROCK1 protein]
CTD PMID:20661774 NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 multiple interactions
increases cleavage
ISO benzoylcarbonyl-valyl-aspartyl-valyl-alanyl-aspartyl-fluoromethyl ketone inhibits the reaction [Ouabain results in increased cleavage of ROCK2 protein] CTD PMID:20661774 NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031
JBrowse link
G Rpa3 replication protein A3 affects expression ISO Ouabain affects the expression of RPA3 protein CTD PMID:17268060 NCBI chr 4:36,304,649...36,307,755
Ensembl chr 4:36,304,651...36,307,709
JBrowse link
G Rpgrip1l Rpgrip1-like decreases expression ISO Ouabain results in decreased expression of RPGRIP1L mRNA CTD PMID:16412265 NCBI chr19:15,692,189...15,785,083
Ensembl chr19:15,692,150...15,785,083
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 affects expression EXP Ouabain affects the expression of RPS6KB1 mRNA CTD PMID:28099878 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Ryr2 ryanodine receptor 2 multiple interactions
increases response to substance
ISO K201 compound inhibits the reaction [RYR2 mutant form results in increased susceptibility to Ouabain] CTD PMID:20080988 NCBI chr17:58,389,925...58,975,641
Ensembl chr17:58,389,925...58,975,142
JBrowse link
G S100a13 S100 calcium binding protein A13 affects expression ISO Ouabain affects the expression of S100A13 protein CTD PMID:17268060 NCBI chr 2:175,999,439...176,005,933 JBrowse link
G S100b S100 calcium binding protein B increases expression EXP Ouabain results in increased expression of S100B protein CTD PMID:15581912 NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 multiple interactions
decreases expression
ISO Ouabain inhibits the reaction [SGK1 protein results in increased transport of Potassium]
Ouabain results in decreased expression of SGK1 mRNA
CTD PMID:12590200 PMID:28795476 NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
JBrowse link
G Sgk2 serum/glucocorticoid regulated kinase 2 multiple interactions ISO Ouabain inhibits the reaction [SGK2 protein results in increased transport of Potassium] CTD PMID:12590200 NCBI chr 3:151,644,102...151,669,480
Ensembl chr 3:151,644,102...151,669,480
JBrowse link
G Sgk3 serum/glucocorticoid regulated kinase family, member 3 multiple interactions ISO Ouabain inhibits the reaction [SGK3 protein results in increased transport of Potassium] CTD PMID:12590200 NCBI chr 5:9,345,761...9,472,243
Ensembl chr 5:9,346,040...9,415,476
JBrowse link
G Shc3 SHC adaptor protein 3 increases expression ISO Ouabain results in increased expression of SHC3 mRNA CTD PMID:28795476 NCBI chr17:13,652,247...13,772,710
Ensembl chr17:13,651,202...13,772,710
JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions ISO Ouabain inhibits the reaction [SLC16A1 protein results in increased uptake of Lactic Acid] CTD PMID:15804185 NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611
JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions ISO Ouabain promotes the reaction [SLC22A12 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:15284287 NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555
JBrowse link
G Slc5a5 solute carrier family 5 member 5 multiple interactions ISO Ouabain inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide] CTD PMID:12541134 NCBI chr16:18,546,709...18,556,698
Ensembl chr16:18,546,709...18,556,697
JBrowse link
G Slc5a6 solute carrier family 5 member 6 multiple interactions ISO Ouabain inhibits the reaction [SLC5A6 protein results in increased transport of Biotin] CTD PMID:15561972 NCBI chr 6:25,319,187...25,331,713
Ensembl chr 6:25,320,442...25,331,712
JBrowse link
G Slc8a1 solute carrier family 8 member A1 affects response to substance
increases expression
multiple interactions
ISO
EXP
SLC8A1 affects the susceptibility to Ouabain
Ouabain results in increased expression of SLC8A1 protein
SLC8A1 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of SLC8A1 protein]; SLC8A1 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of TRPC6 protein]; TRPC6 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of SLC8A1 protein]
CTD PMID:16166162 PMID:19897708 NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628
JBrowse link
G Slc9a1 solute carrier family 9 member A1 multiple interactions
increases expression
EXP N-(2-methyl-4,5-bis(methylsulfonyl)benzoyl)guanidine inhibits the reaction [Ouabain results in increased expression of SLC9A1 mRNA] CTD PMID:19687166 NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624
JBrowse link
G Smad4 SMAD family member 4 decreases expression ISO Ouabain results in decreased expression of SMAD4 mRNA CTD PMID:28795476 NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438
JBrowse link
G Snai1 snail family transcriptional repressor 1 decreases expression ISO Ouabain results in decreased expression of SNAI1 mRNA CTD PMID:33760381 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 decreases expression ISO Ouabain results in decreased expression of SOS1 protein CTD PMID:28795476 NCBI chr 6:14,533,870...14,613,348
Ensembl chr 6:14,533,360...14,611,107
JBrowse link
G Sos2 SOS Ras/Rho guanine nucleotide exchange factor 2 decreases expression ISO Ouabain results in decreased expression of SOS2 mRNA CTD PMID:28795476 NCBI chr 6:88,042,966...88,156,140
Ensembl chr 6:88,042,966...88,156,692
JBrowse link
G Sphk1 sphingosine kinase 1 decreases expression ISO Ouabain results in decreased expression of SPHK1 mRNA CTD PMID:28795476 NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression ISO Ouabain results in decreased expression of TGFB1 mRNA CTD PMID:28795476 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfb2 transforming growth factor, beta 2 decreases expression ISO Ouabain results in decreased expression of TGFB2 mRNA CTD PMID:28795476 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
JBrowse link
G Tgfb3 transforming growth factor, beta 3 decreases expression ISO Ouabain results in decreased expression of TGFB3 mRNA CTD PMID:28795476 NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564
JBrowse link
G Tgfbr3 transforming growth factor beta receptor 3 increases expression ISO Ouabain results in increased expression of TGFBR3 mRNA CTD PMID:28795476 NCBI chr14:2,489,397...2,665,383
Ensembl chr14:2,489,397...2,663,341
JBrowse link
G Tln1 talin 1 decreases expression ISO Ouabain results in decreased expression of TLN1 mRNA CTD PMID:28795476 NCBI chr 5:57,787,670...57,817,900
Ensembl chr 5:57,787,943...57,817,900
JBrowse link
G Tln2 talin 2 decreases expression ISO Ouabain results in decreased expression of TLN2 mRNA CTD PMID:28795476 NCBI chr 8:67,830,920...68,252,223
Ensembl chr 8:67,834,326...68,252,219
JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression ISO Ouabain results in increased expression of TNFRSF10A protein CTD PMID:31436044 NCBI chr15:44,839,818...44,867,582 JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Ouabain results in decreased expression of and results in increased phosphorylation of TP53 protein CTD PMID:31436044 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tpi1 triosephosphate isomerase 1 affects expression ISO Ouabain affects the expression of TPI1 protein CTD PMID:17268060 NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541
JBrowse link
G Tpt1 tumor protein, translationally-controlled 1 affects expression ISO Ouabain affects the expression of TPT1 protein CTD PMID:17268060 NCBI chr15:51,156,728...51,159,629
Ensembl chr15:51,146,154...51,159,625
JBrowse link
G Trim63 tripartite motif containing 63 multiple interactions ISO [Ouabain co-treated with Botulinum Toxins, Type A] affects the expression of TRIM63 mRNA CTD PMID:21139329 NCBI chr 5:146,533,492...146,547,332
Ensembl chr 5:146,533,507...146,547,322
JBrowse link
G Trpc1 transient receptor potential cation channel, subfamily C, member 1 increases expression EXP Ouabain results in increased expression of TRPC1 protein CTD PMID:19897708 NCBI chr 8:96,263,322...96,314,197
Ensembl chr 8:96,263,329...96,314,276
JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 increases expression
multiple interactions
EXP Ouabain results in increased expression of TRPC6 protein
SLC8A1 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of TRPC6 protein]; TRPC6 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of SLC8A1 protein]; TRPC6 mRNA mutant form inhibits the reaction [Ouabain results in increased expression of TRPC6 protein]
CTD PMID:19897708 NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092
JBrowse link
G Twist1 twist family bHLH transcription factor 1 increases expression ISO Ouabain results in increased expression of TWIST1 mRNA CTD PMID:33760381 NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653
JBrowse link
G Txn1 thioredoxin 1 affects expression ISO Ouabain affects the expression of TXN protein CTD PMID:17268060 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
JBrowse link
G Vim vimentin decreases expression ISO Ouabain results in decreased expression of VIM mRNA CTD PMID:33760381 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Zfhx3 zinc finger homeobox 3 decreases expression ISO Ouabain results in decreased expression of ZFHX3 mRNA CTD PMID:16412265 NCBI chr19:36,257,196...36,886,104
Ensembl chr19:36,630,254...36,881,771
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    role 19769
      biological role 19769
        molecular messenger 18316
          hormone 18081
            steroid hormone 7802
              ouabain 196
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            heteroorganic entity 19294
                              organochalcogen compound 19064
                                organooxygen compound 19014
                                  carbohydrates and carbohydrate derivatives 12341
                                    carbohydrate 12341
                                      carbohydrate derivative 11947
                                        glycosyl compound 10977
                                          glycoside 9260
                                            deoxy hexoside 7504
                                              rhamnoside 442
                                                alpha-L-rhamnoside 442
                                                  ouabain 196
paths to the root