strophanthidin - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	strophanthidin	go back to main search page
Accession:	CHEBI:38178	browse the term
Definition:	A cardenolide that has formula C23H32O6.
Synonyms:	exact_synonym:	3beta,5,14-trihydroxy-19-oxo-5beta-card-20(22)-enolide
	related_synonym:	5beta-Hydroxy-19-oxodigitoxigenin; Convallatoxigenin; Corchorgenin; Corchorin; Corchoside A aglycon; Corchsularin; Erysimupicrone; Formula=C23H32O6; InChI=1S/C23H32O6/c1-20-6-3-17-18(4-8-22(27)11-15(25)2-7-21(17,22)13-24)23(20,28)9-5-16(20)14-10-19(26)29-12-14/h10,13,15-18,25,27-28H,2-9,11-12H2,1H3/t15-,16+,17-,18+,20+,21-,22-,23-/m0/s1; InChIKey=ODJLBQGVINUMMR-HZXDTFASSA-N; SMILES=[H][C@@]1(CC[C@]2(O)[C@]3([H])CC[C@]4(O)C[C@@H](O)CC[C@]4(C=O)[C@@]3([H])CC[C@]12C)C1=CC(=O)OC1; Strophanthidin K; Strophanthidine
	xref:	Beilstein:97859; CAS:66-28-4; LINCS:LSM-3891
	xref_mesh:	MESH:D013327

show annotations for term's descendants Sort by:

Rat (6) Mouse (6) Human (6) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (6)

strophanthidin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 1A

increases transport

ABCB1 protein results in increased transport of Strophanthidin

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

G

glucose-6-phosphatase catalytic subunit 1

increases expression
multiple interactions

Strophanthidin results in increased expression of G6PC1 mRNA
Strophanthidin promotes the reaction [RORC protein binds to G6PC1 promoter]

NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804

G

interleukin 17A

multiple interactions

Strophanthidin results in increased expression of and results in increased secretion of IL17A protein

NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889

G

interleukin 17F

multiple interactions

Strophanthidin results in increased expression of and results in increased secretion of IL17F protein

NCBI chr 9:23,190,094...23,201,482
Ensembl chr 9:23,190,100...23,201,482

G

neuronal PAS domain protein 2

increases expression
multiple interactions

Strophanthidin results in increased expression of NPAS2 mRNA
Strophanthidin promotes the reaction [RORC protein binds to NPAS2 promoter]

NCBI chr 9:41,463,361...41,642,322
Ensembl chr 9:41,463,830...41,642,320

G

RAR-related orphan receptor C

multiple interactions
increases expression

RORC protein promotes the reaction [Strophanthidin results in increased expression of RORC mRNA]; Strophanthidin promotes the reaction [RORC protein binds to G6PC1 promoter]; Strophanthidin promotes the reaction [RORC protein binds to NPAS2 promoter]

NCBI chr 2:182,009,707...182,034,910
Ensembl chr 2:182,009,286...182,034,907

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	20072
role	20024
application	19760
solvent	16703
formic acid	8846
formyl group	8819
aldehyde	8819
steroid aldehyde	92
strophanthidin	6
3beta-[(O-beta-D-glucopyranosyl-(1->3)-4,6-dideoxy-2-O-methyl-beta-D-gulopyranosyl)]-5beta,14beta-dihydroxy-19-oxocard-20(22)enolide	0
acetylstrophanthidin	0
convallatoxin	0
erysimoside	0
Path 2
Term	Annotations
CHEBI ontology	20072
subatomic particle	20071
composite particle	20071
hadron	20071
baryon	20071
nucleon	20071
atomic nucleus	20071
atom	20071
main group element atom	19971
p-block element atom	19971
carbon group element atom	19894
carbon atom	19887
organic molecular entity	19887
organic group	18965
organic divalent group	18951
organodiyl group	18951
carbonyl group	18903
carbonyl compound	18903
carboxylic acid	18601
carboacyl group	17713
univalent carboacyl group	17713
formyl group	8819
aldehyde	8819
steroid aldehyde	92
strophanthidin	6
3beta-[(O-beta-D-glucopyranosyl-(1->3)-4,6-dideoxy-2-O-methyl-beta-D-gulopyranosyl)]-5beta,14beta-dihydroxy-19-oxocard-20(22)enolide	0
acetylstrophanthidin	0
convallatoxin	0
erysimoside	0

paths to the root