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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:strophanthidin
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Accession:CHEBI:38178 term browser browse the term
Definition:A cardenolide that has formula C23H32O6.
Synonyms:exact_synonym: 3beta,5,14-trihydroxy-19-oxo-5beta-card-20(22)-enolide
 related_synonym: 5beta-Hydroxy-19-oxodigitoxigenin;   Convallatoxigenin;   Corchorgenin;   Corchorin;   Corchoside A aglycon;   Corchsularin;   Erysimupicrone;   Formula=C23H32O6;   InChI=1S/C23H32O6/c1-20-6-3-17-18(4-8-22(27)11-15(25)2-7-21(17,22)13-24)23(20,28)9-5-16(20)14-10-19(26)29-12-14/h10,13,15-18,25,27-28H,2-9,11-12H2,1H3/t15-,16+,17-,18+,20+,21-,22-,23-/m0/s1;   InChIKey=ODJLBQGVINUMMR-HZXDTFASSA-N;   SMILES=[H][C@@]1(CC[C@]2(O)[C@]3([H])CC[C@]4(O)C[C@@H](O)CC[C@]4(C=O)[C@@]3([H])CC[C@]12C)C1=CC(=O)OC1;   Strophanthidin K;   Strophanthidine
 xref: Beilstein:97859;   CAS:66-28-4;   LINCS:LSM-3891
 xref_mesh: MESH:D013327


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strophanthidin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases transport ISO ABCB1 protein results in increased transport of Strophanthidin CTD PMID:26708294 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 increases expression
multiple interactions
ISO Strophanthidin results in increased expression of G6PC1 mRNA
Strophanthidin promotes the reaction [RORC protein binds to G6PC1 promoter]
CTD PMID:29981919 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
JBrowse link
G Il17a interleukin 17A multiple interactions ISO Strophanthidin results in increased expression of and results in increased secretion of IL17A protein CTD PMID:29981919 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il17f interleukin 17F multiple interactions ISO Strophanthidin results in increased expression of and results in increased secretion of IL17F protein CTD PMID:29981919 NCBI chr 9:26,885,702...26,897,219
Ensembl chr 9:26,885,708...26,897,219
JBrowse link
G Npas2 neuronal PAS domain protein 2 increases expression
multiple interactions
ISO Strophanthidin results in increased expression of NPAS2 mRNA
Strophanthidin promotes the reaction [RORC protein binds to NPAS2 promoter]
CTD PMID:29981919 NCBI chr 9:45,901,262...46,081,880
Ensembl chr 9:45,901,741...46,081,880
JBrowse link
G Rorc RAR-related orphan receptor C multiple interactions
increases expression
ISO RORC protein promotes the reaction [Strophanthidin results in increased expression of RORC mRNA]; Strophanthidin promotes the reaction [RORC protein binds to G6PC1 promoter]; Strophanthidin promotes the reaction [RORC protein binds to NPAS2 promoter] CTD PMID:29981919 NCBI chr 2:195,612,471...195,636,797
Ensembl chr 2:195,617,021...195,637,630
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19853
    role 19804
      application 19477
        solvent 16555
          formic acid 8779
            formyl group 8752
              aldehyde 8752
                steroid aldehyde 91
                  strophanthidin 6
                    3beta-[(O-beta-D-glucopyranosyl-(1->3)-4,6-dideoxy-2-O-methyl-beta-D-gulopyranosyl)]-5beta,14beta-dihydroxy-19-oxocard-20(22)enolide 0
                    acetylstrophanthidin 0
                    convallatoxin 0
                    erysimoside 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19853
    subatomic particle 19851
      composite particle 19851
        hadron 19851
          baryon 19851
            nucleon 19851
              atomic nucleus 19851
                atom 19851
                  main group element atom 19744
                    p-block element atom 19744
                      carbon group element atom 19650
                        carbon atom 19639
                          organic molecular entity 19639
                            organic group 18550
                              organic divalent group 18541
                                organodiyl group 18541
                                  carbonyl group 18447
                                    carbonyl compound 18447
                                      carboxylic acid 18125
                                        carboacyl group 17383
                                          univalent carboacyl group 17383
                                            formyl group 8752
                                              aldehyde 8752
                                                steroid aldehyde 91
                                                  strophanthidin 6
                                                    3beta-[(O-beta-D-glucopyranosyl-(1->3)-4,6-dideoxy-2-O-methyl-beta-D-gulopyranosyl)]-5beta,14beta-dihydroxy-19-oxocard-20(22)enolide 0
                                                    acetylstrophanthidin 0
                                                    convallatoxin 0
                                                    erysimoside 0
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