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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:thalidomide
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Accession:CHEBI:9513 term browser browse the term
Definition:A racemate comprising equimolar amounts of R- and S-thalidomide.
Synonyms:exact_synonym: rac-2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione
 related_synonym: 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)isoindoline;   2,6-dioxo-3-phthalimidopiperidine;   3-phthalimidoglutarimide;   Distaval;   Formula=C13H10N2O4;   K-17;   N-(2,6-dioxo-3-piperidyl)phthalimide;   N-Phthalyl-glutaminsaeure-imid;   N-phthaloylglutamimide;   N-phthalylglutamic acid imide;   Sedalis;   Softenon;   Talimol;   alpha-(N-phthalimido)glutarimide;   alpha-N-phthalylglutaramide;   alpha-phthalimidoglutarimide;   talidomida;   thalidomidum
 xref: CAS:50-35-1;   DrugBank:DB01041;   HMDB:HMDB0015175;   KEGG:C07910;   KEGG:D00754;   LINCS:LSM-1914
 xref_mesh: MESH:D013792
 xref: PMID:11349879;   PMID:11803357;   PMID:12724820;   PMID:14689682;   PMID:17449064;   PMID:18925849;   PMID:21207098;   PMID:2694291;   PMID:8469046;   Patent:GB768821;   Patent:US2012142734;   Patent:WO2013100657;   Reaxys:30233;   Wikipedia:Thalidomide


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thalidomide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AADAT aminoadipate aminotransferase decreases expression ISO Thalidomide results in decreased expression of AADAT mRNA CTD PMID:26217789 NCBI chr 4:170,060,222...170,094,292
Ensembl chr 4:170,060,222...170,091,699 		JBrowse link
G ABCA1 ATP binding cassette subfamily A member 1 increases response to substance EXP ABCA1 gene SNP results in increased susceptibility to Thalidomide CTD PMID:21245421 NCBI chr 9:104,781,006...104,928,155
Ensembl chr 9:104,781,006...104,928,155 		JBrowse link
G ABCB1 ATP binding cassette subfamily B member 1 decreases expression
decreases activity		 EXP Thalidomide results in decreased expression of ABCB1 mRNA; Thalidomide results in decreased expression of ABCB1 protein
Thalidomide results in decreased activity of ABCB1 protein		 CTD PMID:15920492 PMID:19840843 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G ACP5 acid phosphatase 5, tartrate resistant multiple interactions EXP [Thalidomide co-treated with Dexamethasone] results in decreased expression of ACP5 protein CTD PMID:16079895 NCBI chr19:11,574,660...11,578,975
Ensembl chr19:11,574,653...11,579,993 		JBrowse link
G ACTA2 actin alpha 2, smooth muscle multiple interactions
decreases expression		 ISO [Thalidomide co-treated with Dimethylnitrosamine] results in decreased expression of ACTA2 protein; Thalidomide inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; Thalidomide inhibits the reaction [Dimethylnitrosamine results in increased expression of ACTA2 mRNA]; Thalidomide inhibits the reaction [Dimethylnitrosamine results in increased expression of ACTA2 protein]; Thalidomide inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]
Thalidomide results in decreased expression of ACTA2 protein		 CTD PMID:16604421 PMID:16943688 PMID:17030452 PMID:17174718 NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,934,822...88,991,339 		JBrowse link
G ACTN2 actinin alpha 2 decreases expression ISO Thalidomide results in decreased expression of ACTN2 mRNA CTD PMID:26006729 PMID:26217789 NCBI chr 1:236,686,499...236,764,631
Ensembl chr 1:236,664,141...236,764,631 		JBrowse link
G ACTR6 actin related protein 6 decreases expression ISO Thalidomide results in decreased expression of ACTR6 mRNA CTD PMID:26217789 NCBI chr12:100,200,815...100,224,424
Ensembl chr12:100,199,122...100,241,865 		JBrowse link
G ADSS1 adenylosuccinate synthase 1 decreases expression ISO Thalidomide results in decreased expression of ADSS1 mRNA CTD PMID:26217789 NCBI chr14:104,724,229...104,747,325
Ensembl chr14:104,724,174...104,747,325 		JBrowse link
G AFF2 ALF transcription elongation factor 2 decreases expression ISO Thalidomide results in decreased expression of AFF2 mRNA CTD PMID:26217789 NCBI chr  X:148,500,617...149,000,663
Ensembl chr  X:148,500,617...149,000,663 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 decreases phosphorylation
decreases activity
increases phosphorylation		 EXP Thalidomide analog results in decreased phosphorylation of AKT1 protein
Thalidomide results in decreased activity of AKT1 protein
Thalidomide analog results in increased phosphorylation of AKT1 protein		 CTD PMID:15067094 PMID:15858615 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,759 		JBrowse link
G ALDH1A2 aldehyde dehydrogenase 1 family member A2 decreases expression EXP Thalidomide results in decreased expression of ALDH1A2 mRNA CTD PMID:31711903 NCBI chr15:57,953,429...58,065,711
Ensembl chr15:57,953,424...58,497,866 		JBrowse link
G ALPI alkaline phosphatase, intestinal increases expression ISO Thalidomide results in increased expression of ALPI mRNA CTD PMID:26217789 NCBI chr 2:232,456,153...232,460,753
Ensembl chr 2:232,456,125...232,460,753 		JBrowse link
G AMACR alpha-methylacyl-CoA racemase decreases expression ISO Thalidomide results in decreased expression of AMACR mRNA CTD PMID:26217789 NCBI chr 5:33,986,165...34,008,050
Ensembl chr 5:33,986,165...34,008,104 		JBrowse link
G ANGPT2 angiopoietin 2 affects expression EXP Thalidomide affects the expression of ANGPT2 mRNA CTD PMID:15939924 NCBI chr 8:6,499,632...6,563,245
Ensembl chr 8:6,499,632...6,563,409 		JBrowse link
G ANKRD37 ankyrin repeat domain 37 decreases expression ISO Thalidomide results in decreased expression of ANKRD37 mRNA CTD PMID:26217789 NCBI chr 4:185,396,841...185,400,723
Ensembl chr 4:185,396,021...185,400,628 		JBrowse link
G ANXA2 annexin A2 decreases expression EXP Thalidomide results in decreased expression of ANXA2 mRNA; Thalidomide results in decreased expression of ANXA2 protein CTD PMID:19954599 NCBI chr15:60,347,151...60,397,986
Ensembl chr15:60,347,134...60,402,883 		JBrowse link
G APIP APAF1 interacting protein decreases expression ISO Thalidomide results in decreased expression of APIP mRNA CTD PMID:26217789 NCBI chr11:34,882,295...34,916,379
Ensembl chr11:34,853,094...34,916,379 		JBrowse link
G APLN apelin decreases expression ISO Thalidomide results in decreased expression of APLN mRNA CTD PMID:26217789 NCBI chr  X:129,645,259...129,654,956
Ensembl chr  X:129,645,259...129,654,956 		JBrowse link
G AQP4 aquaporin 4 increases expression ISO Thalidomide results in increased expression of AQP4 mRNA CTD PMID:26217789 NCBI chr18:26,852,038...26,865,803
Ensembl chr18:26,852,043...26,865,771 		JBrowse link
G AQP5 aquaporin 5 increases expression ISO Thalidomide results in increased expression of AQP5 mRNA CTD PMID:26217789 NCBI chr12:49,961,872...49,965,682
Ensembl chr12:49,961,872...49,965,682 		JBrowse link
G ARHGDIA Rho GDP dissociation inhibitor alpha increases expression ISO Thalidomide results in increased expression of ARHGDIA mRNA CTD PMID:26217789 NCBI chr17:81,867,721...81,871,337
Ensembl chr17:81,867,721...81,871,378 		JBrowse link
G ARPC4 actin related protein 2/3 complex subunit 4 decreases expression ISO Thalidomide results in decreased expression of ARPC4 mRNA CTD PMID:26217789 NCBI chr 3:9,792,518...9,807,101
Ensembl chr 3:9,792,495...9,807,101 		JBrowse link
G ARX aristaless related homeobox increases expression ISO Thalidomide results in increased expression of ARX mRNA CTD PMID:26217789 NCBI chr  X:25,003,694...25,015,965
Ensembl chr  X:25,003,694...25,016,420 		JBrowse link
G ASB12 ankyrin repeat and SOCS box containing 12 decreases expression ISO Thalidomide results in decreased expression of ASB12 mRNA CTD PMID:26217789 NCBI chr  X:64,224,194...64,230,607
Ensembl chr  X:64,224,194...64,230,607 		JBrowse link
G ATF3 activating transcription factor 3 increases expression EXP Thalidomide analog results in increased expression of ATF3 mRNA CTD PMID:20525221 NCBI chr 1:212,565,407...212,620,777
Ensembl chr 1:212,565,334...212,620,777 		JBrowse link
G AURKA aurora kinase A multiple interactions EXP [Azacitidine co-treated with Thalidomide] affects the expression of AURKA mRNA CTD PMID:18720364 NCBI chr20:56,369,390...56,392,215
Ensembl chr20:56,369,389...56,392,337 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression ISO Thalidomide results in increased expression of BAX mRNA CTD PMID:18291259 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCAP29 B cell receptor associated protein 29 decreases expression ISO Thalidomide results in decreased expression of BCAP29 mRNA CTD PMID:26217789 NCBI chr 7:107,580,007...107,623,317
Ensembl chr 7:107,580,246...107,629,170 		JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions
decreases expression		 EXP [oblimersen co-treated with Thalidomide co-treated with Dexamethasone] results in decreased expression of BCL2 mRNA; [oblimersen co-treated with Thalidomide co-treated with Dexamethasone] results in decreased expression of BCL2 protein
Thalidomide results in decreased expression of BCL2 protein		 CTD PMID:15867202 PMID:15982930 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BCL2L1 BCL2 like 1 decreases expression EXP Thalidomide results in decreased expression of BCL2L1 protein CTD PMID:15986355 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989 		JBrowse link
G BDKRB1 bradykinin receptor B1 multiple interactions ISO Thalidomide inhibits the reaction [bradykinin, des-Arg(9)- results in increased expression of BDKRB1 protein] CTD PMID:16039549 NCBI chr14:96,256,210...96,264,763
Ensembl chr14:96,256,210...96,268,967 		JBrowse link
G BECN1 beclin 1 multiple interactions EXP Thalidomide promotes the reaction [temozolomide results in increased expression of BECN1 protein] CTD PMID:19567134 NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350 		JBrowse link
G BNIPL BCL2 interacting protein like increases expression ISO Thalidomide results in increased expression of BNIPL mRNA CTD PMID:26217789 NCBI chr 1:151,036,586...151,047,720
Ensembl chr 1:151,036,321...151,047,720 		JBrowse link
G BOD1 biorientation of chromosomes in cell division 1 decreases expression ISO Thalidomide results in decreased expression of BOD1 mRNA CTD PMID:26217789 NCBI chr 5:173,607,145...173,616,650
Ensembl chr 5:173,607,145...173,616,659 		JBrowse link
G BST2 bone marrow stromal cell antigen 2 decreases expression ISO Thalidomide results in decreased expression of BST2 mRNA CTD PMID:26217789 NCBI chr19:17,402,939...17,405,630
Ensembl chr19:17,402,939...17,405,630 		JBrowse link
G BUB1B BUB1 mitotic checkpoint serine/threonine kinase B multiple interactions EXP [Azacitidine co-treated with Thalidomide] affects the expression of BUB1B mRNA CTD PMID:18720364 NCBI chr15:40,161,069...40,221,123
Ensembl chr15:40,161,023...40,221,123 		JBrowse link
G C3 complement C3 decreases expression EXP Thalidomide results in decreased expression of C3 protein CTD PMID:2985516 NCBI chr19:6,677,704...6,720,650
Ensembl chr19:6,677,704...6,730,562 		JBrowse link
G CACNA1C calcium voltage-gated channel subunit alpha1 C decreases expression ISO Thalidomide results in decreased expression of CACNA1C mRNA CTD PMID:26006729 PMID:26217789 NCBI chr12:1,970,780...2,697,950
Ensembl chr12:1,970,772...2,697,950 		JBrowse link
G CACNB4 calcium voltage-gated channel auxiliary subunit beta 4 decreases expression EXP Thalidomide results in decreased expression of CACNB4 mRNA CTD PMID:32756504 NCBI chr 2:151,832,771...152,099,167
Ensembl chr 2:151,832,771...152,099,167 		JBrowse link
G CALB1 calbindin 1 decreases expression EXP Thalidomide results in decreased expression of CALB1 mRNA CTD PMID:24154490 NCBI chr 8:90,058,608...90,082,879
Ensembl chr 8:90,058,608...90,095,475 		JBrowse link
G CASP3 caspase 3 decreases activity
increases expression
increases activity		 EXP
ISO		 Thalidomide results in decreased activity of CASP3 protein
Thalidomide results in increased expression of CASP3 mRNA
Thalidomide results in increased activity of CASP3 protein		 CTD PMID:14682394 PMID:15067094 PMID:18291259 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP8 caspase 8 increases cleavage
decreases expression		 EXP
ISO		 Thalidomide analog results in increased cleavage of CASP8 protein
Thalidomide results in decreased expression of CASP8 mRNA		 CTD PMID:15858615 PMID:26217789 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836 		JBrowse link
G CASP9 caspase 9 decreases activity EXP Thalidomide results in decreased activity of CASP9 protein CTD PMID:15067094 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CASTOR1 cytosolic arginine sensor for mTORC1 subunit 1 decreases expression ISO Thalidomide results in decreased expression of CASTOR1 mRNA CTD PMID:26217789 NCBI chr22:30,285,117...30,289,505
Ensembl chr22:30,285,117...30,289,622 		JBrowse link
G CAT catalase multiple interactions EXP CAT protein inhibits the reaction [Thalidomide results in decreased activity of MYB protein] CTD PMID:16616857 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CBR1 carbonyl reductase 1 decreases expression ISO Thalidomide results in decreased expression of CBR1 mRNA CTD PMID:26217789 NCBI chr21:36,070,024...36,073,164
Ensembl chr21:36,069,941...36,073,166 		JBrowse link
G CCDC141 coiled-coil domain containing 141 decreases expression ISO Thalidomide results in decreased expression of CCDC141 mRNA CTD PMID:26217789 NCBI chr 2:178,814,978...179,050,137
Ensembl chr 2:178,829,757...179,050,137 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 decreases expression EXP Thalidomide analog results in decreased expression of CCL2 mRNA CTD PMID:20525221 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CCL3 C-C motif chemokine ligand 3 increases expression ISO Thalidomide results in increased expression of CCL3 mRNA CTD PMID:16549389 NCBI chr17:36,088,256...36,090,143
Ensembl chr17:36,088,256...36,090,169 		JBrowse link
G CCNA2 cyclin A2 multiple interactions EXP [Azacitidine co-treated with Thalidomide] affects the expression of CCNA2 mRNA CTD PMID:18720364 NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883 		JBrowse link
G CCNB1 cyclin B1 multiple interactions EXP [Azacitidine co-treated with Thalidomide] affects the expression of CCNB1 mRNA CTD PMID:18720364 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245 		JBrowse link
G CCND1 cyclin D1 decreases expression EXP Thalidomide analog results in decreased expression of CCND1 mRNA CTD PMID:20525221 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474 		JBrowse link
G CCNO cyclin O increases expression ISO Thalidomide results in increased expression of CCNO mRNA CTD PMID:26217789 NCBI chr 5:55,231,152...55,233,608
Ensembl chr 5:55,231,152...55,233,608 		JBrowse link
G CD24 CD24 molecule affects expression ISO Thalidomide affects the expression of CD24A mRNA CTD PMID:26006729 NCBI chr 6:106,969,831...106,976,855
Ensembl chr 6:106,969,831...106,975,627 		JBrowse link
G CD274 CD274 molecule decreases expression
multiple interactions		 EXP Thalidomide results in decreased expression of CD274 protein
FGD5-AS1 inhibits the reaction [Thalidomide results in decreased expression of CD274 protein]		 CTD PMID:34520751 NCBI chr 9:5,450,542...5,470,554
Ensembl chr 9:5,450,503...5,470,566 		JBrowse link
G CDC20 cell division cycle 20 multiple interactions EXP [Azacitidine co-treated with Thalidomide] affects the expression of CDC20 mRNA CTD PMID:18720364 NCBI chr 1:43,358,981...43,363,203
Ensembl chr 1:43,358,981...43,363,203 		JBrowse link
G CDC42EP5 CDC42 effector protein 5 decreases expression ISO Thalidomide results in decreased expression of CDC42EP5 mRNA CTD PMID:26006729 PMID:26217789 NCBI chr19:54,465,026...54,473,296
Ensembl chr19:54,465,026...54,473,296 		JBrowse link
G CDH1 cadherin 1 multiple interactions
increases expression		 EXP FGD5-AS1 inhibits the reaction [Thalidomide results in increased expression of CDH1 protein] CTD PMID:34520751 NCBI chr16:68,737,292...68,835,537
Ensembl chr16:68,737,292...68,835,537 		JBrowse link
G CDH10 cadherin 10 decreases expression ISO Thalidomide results in decreased expression of CDH10 mRNA CTD PMID:26217789 NCBI chr 5:24,487,100...24,644,978
Ensembl chr 5:24,487,100...24,644,978 		JBrowse link
G CDH2 cadherin 2 multiple interactions
decreases expression		 EXP FGD5-AS1 inhibits the reaction [Thalidomide results in decreased expression of CDH2 protein] CTD PMID:34520751 NCBI chr18:27,932,879...28,177,130
Ensembl chr18:27,932,879...28,177,946 		JBrowse link
G CDH6 cadherin 6 increases expression EXP Thalidomide results in increased expression of CDH6 mRNA CTD PMID:32756504 NCBI chr 5:31,193,686...31,329,146
Ensembl chr 5:31,193,686...31,329,146 		JBrowse link
G CDK1 cyclin dependent kinase 1 multiple interactions EXP [Azacitidine co-treated with Thalidomide] affects the expression of CDK1 mRNA CTD PMID:18720364 NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852 		JBrowse link
G CENPA centromere protein A multiple interactions EXP [Azacitidine co-treated with Thalidomide] affects the expression of CENPA mRNA CTD PMID:18720364 NCBI chr 2:26,786,056...26,794,589
Ensembl chr 2:26,764,289...26,801,067 		JBrowse link
G CENPF centromere protein F multiple interactions EXP [Azacitidine co-treated with Thalidomide] affects the expression of CENPF mRNA CTD PMID:18720364 NCBI chr 1:214,603,195...214,664,571
Ensembl chr 1:214,603,185...214,664,574 		JBrowse link
G CER1 cerberus 1, DAN family BMP antagonist decreases expression ISO Thalidomide results in decreased expression of CER1 mRNA CTD PMID:26217789 NCBI chr 9:14,717,326...14,722,733
Ensembl chr 9:14,719,724...14,722,733 		JBrowse link
G CFLAR CASP8 and FADD like apoptosis regulator decreases expression EXP Thalidomide results in decreased expression of CFLAR protein CTD PMID:15986355 NCBI chr 2:201,116,164...201,176,687
Ensembl chr 2:201,116,154...201,176,687 		JBrowse link
G CHUK component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO Thalidomide inhibits the reaction [TNF protein results in increased expression of CHUK protein] CTD PMID:16604421 NCBI chr10:100,186,319...100,229,596
Ensembl chr10:100,188,300...100,229,596 		JBrowse link
G CHURC1 churchill domain containing 1 decreases expression ISO Thalidomide results in decreased expression of CHURC1 mRNA CTD PMID:26217789 NCBI chr14:64,914,455...64,935,368
Ensembl chr14:64,914,361...64,944,591 		JBrowse link
G CLDN4 claudin 4 increases expression ISO Thalidomide results in increased expression of CLDN4 mRNA CTD PMID:26217789 NCBI chr 7:73,830,996...73,832,690
Ensembl chr 7:73,799,542...73,832,690 		JBrowse link
G CLDND1 claudin domain containing 1 decreases expression ISO Thalidomide results in decreased expression of CLDND1 mRNA CTD PMID:26217789 NCBI chr 3:98,515,483...98,522,902
Ensembl chr 3:98,497,912...98,523,066 		JBrowse link
G CLEC9A C-type lectin domain containing 9A decreases expression ISO Thalidomide results in decreased expression of CLEC9A mRNA CTD PMID:26217789 NCBI chr12:10,030,682...10,066,031
Ensembl chr12:10,030,678...10,066,031 		JBrowse link
G COL1A1 collagen type I alpha 1 chain multiple interactions ISO Thalidomide inhibits the reaction [Paraquat results in increased expression of COL1A1 mRNA]; Thalidomide inhibits the reaction [Paraquat results in increased expression of COL1A1 protein] CTD PMID:26221080 NCBI chr17:50,184,101...50,201,631
Ensembl chr17:50,184,101...50,201,632 		JBrowse link
G COL1A2 collagen type I alpha 2 chain multiple interactions ISO Thalidomide inhibits the reaction [Dimethylnitrosamine results in increased expression of COL1A2 mRNA]; Thalidomide inhibits the reaction [TNF protein results in increased expression of COL1A2 mRNA] CTD PMID:16604421 NCBI chr 7:94,394,895...94,431,227
Ensembl chr 7:94,394,895...94,431,227 		JBrowse link
G CPLX3 complexin 3 decreases expression EXP Thalidomide results in decreased expression of CPLX3 mRNA CTD PMID:32756504 NCBI chr15:74,826,627...74,831,802
Ensembl chr15:74,826,627...74,831,802 		JBrowse link
G CRBN cereblon multiple interactions
affects binding
affects response to substance		 EXP
ISO		 Thalidomide inhibits the reaction [CRBN protein binds to and results in increased ubiquitination of and results in increased degradation of MEIS2 protein]
Thalidomide binds to [CRBN protein binds to DDB1 protein]
CRBN gene SNP affects the susceptibility to Thalidomide
Thalidomide binds to [SALL4 protein binds to CRBN protein]; Thalidomide binds to CRBN protein		 CTD PMID:25043012 PMID:25108355 PMID:27751757 PMID:30067223 NCBI chr 3:3,149,633...3,179,717
Ensembl chr 3:3,144,628...3,179,727 		JBrowse link
G CREB5 cAMP responsive element binding protein 5 decreases expression EXP Thalidomide results in decreased expression of CREB5 mRNA CTD PMID:32756504 NCBI chr 7:28,299,321...28,825,894
Ensembl chr 7:28,299,321...28,825,894 		JBrowse link
G CREBRF CREB3 regulatory factor increases expression EXP Thalidomide analog results in increased expression of CREBRF mRNA CTD PMID:20525221 NCBI chr 5:173,056,352...173,139,284
Ensembl chr 5:173,056,352...173,139,284 		JBrowse link
G CRIPTO cripto, EGF-CFC family member decreases expression ISO Thalidomide results in decreased expression of CRIPTO mRNA CTD PMID:26006729 PMID:26217789 NCBI chr 3:46,574,535...46,582,457
Ensembl chr 3:46,574,534...46,582,457 		JBrowse link
G CRP C-reactive protein decreases expression EXP Thalidomide results in decreased expression of CRP protein CTD PMID:11339241 NCBI chr 1:159,712,289...159,714,589
Ensembl chr 1:159,712,289...159,714,589 		JBrowse link
G CSF2 colony stimulating factor 2 decreases activity EXP Thalidomide results in decreased activity of CSF2 protein CTD PMID:17557286 NCBI chr 5:132,073,789...132,076,170
Ensembl chr 5:132,073,789...132,076,170 		JBrowse link
G CSF3 colony stimulating factor 3 decreases activity EXP Thalidomide results in decreased activity of CSF3 protein CTD PMID:17557286 NCBI chr17:40,015,440...40,017,813
Ensembl chr17:40,015,361...40,017,813 		JBrowse link
G CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 decreases expression ISO Thalidomide results in decreased expression of CSGALNACT2 mRNA CTD PMID:26217789 NCBI chr10:43,138,445...43,185,308
Ensembl chr10:43,138,445...43,185,302 		JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 increases expression ISO Thalidomide results in increased expression of CXCL10 CTD PMID:17089043 NCBI chr 4:76,021,118...76,023,497
Ensembl chr 4:76,021,118...76,023,497 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions
decreases activity		 EXP Thalidomide inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Thalidomide inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]
Thalidomide results in decreased activity of CXCL8 protein		 CTD PMID:15687330 PMID:17557286 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G CXCR1 C-X-C motif chemokine receptor 1 decreases expression EXP Thalidomide results in decreased expression of CXCR1 protein CTD PMID:16344495 NCBI chr 2:218,162,841...218,166,962
Ensembl chr 2:218,162,841...218,166,962 		JBrowse link
G CXCR2 C-X-C motif chemokine receptor 2 decreases expression EXP Thalidomide results in decreased expression of CXCR2 protein CTD PMID:16344495 NCBI chr 2:218,125,294...218,137,251
Ensembl chr 2:218,125,289...218,137,251 		JBrowse link
G CYCS cytochrome c, somatic increases expression EXP Thalidomide results in increased expression of CYCS protein CTD PMID:15982930 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260 		JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 increases expression EXP Thalidomide results in increased expression of CYP2B6 mRNA CTD PMID:24460184 PMID:28496040 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398 		JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 multiple interactions
increases oxidation
increases hydroxylation		 EXP [CYP2C19 protein results in increased hydroxylation of Thalidomide] which results in increased chemical synthesis of 5'-hydroxythalidomide; [CYP2C19 protein results in increased hydroxylation of Thalidomide] which results in increased chemical synthesis of 5-hydroxythalidomide; [CYP2C19 protein results in increased oxidation of Thalidomide] which results in increased abundance of 5'-hydroxythalidomide; [CYP2C19 protein results in increased oxidation of Thalidomide] which results in increased abundance of 5-hydroxythalidomide CTD PMID:20443640 PMID:24350712 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 multiple interactions
increases metabolic processing
increases expression
increases hydroxylation		 EXP [CYP3A4 protein results in increased hydroxylation of Thalidomide] which results in increased chemical synthesis of 5-hydroxythalidomide
CYP3A4 protein results in increased metabolism of Thalidomide
Thalidomide results in increased expression of CYP3A4 mRNA; Thalidomide results in increased expression of CYP3A4 protein		 CTD PMID:20443640 PMID:24460184 PMID:28496040 PMID:28745489 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 multiple interactions
increases metabolic processing
increases expression
increases hydroxylation		 EXP [CYP3A5 protein results in increased hydroxylation of Thalidomide] which results in increased chemical synthesis of 5-hydroxythalidomide
CYP3A5 protein results in increased metabolism of Thalidomide
Thalidomide results in increased expression of CYP3A5 mRNA		 CTD PMID:20443640 PMID:28496040 PMID:28745489 NCBI chr 7:99,648,194...99,679,996
Ensembl chr 7:99,648,194...99,679,996 		JBrowse link
G CYP3A7 cytochrome P450 family 3 subfamily A member 7 multiple interactions
increases hydroxylation		 EXP [CYP3A7 protein results in increased hydroxylation of Thalidomide] which results in increased chemical synthesis of 5-hydroxythalidomide CTD PMID:20443640 NCBI chr 7:99,705,036...99,735,196
Ensembl chr 7:99,705,036...99,735,196 		JBrowse link
G CYTH3 cytohesin 3 decreases expression ISO Thalidomide results in decreased expression of CYTH3 mRNA CTD PMID:26217789 NCBI chr 7:6,161,779...6,272,624
Ensembl chr 7:6,161,779...6,272,644 		JBrowse link
G DAAM2 dishevelled associated activator of morphogenesis 2 decreases expression ISO Thalidomide results in decreased expression of DAAM2 mRNA CTD PMID:26217789 NCBI chr 6:39,792,376...39,904,869
Ensembl chr 6:39,792,298...39,904,877 		JBrowse link
G DBT dihydrolipoamide branched chain transacylase E2 decreases expression ISO Thalidomide results in decreased expression of DBT mRNA CTD PMID:26217789 NCBI chr 1:100,186,919...100,249,834
Ensembl chr 1:100,186,919...100,249,834 		JBrowse link
G DDB1 damage specific DNA binding protein 1 affects binding ISO Thalidomide binds to [CRBN protein binds to DDB1 protein] CTD PMID:25108355 NCBI chr11:61,299,451...61,333,105
Ensembl chr11:61,299,451...61,342,596 		JBrowse link
G DDIT3 DNA damage inducible transcript 3 increases expression EXP Thalidomide analog results in increased expression of DDIT3 mRNA CTD PMID:20525221 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737 		JBrowse link
G DEFA3 defensin alpha 3 increases expression ISO Thalidomide results in increased expression of DEFA3 mRNA CTD PMID:26217789 NCBI chr 8:7,015,869...7,018,297
Ensembl chr 8:7,015,869...7,018,297 		JBrowse link
G DEFB106B defensin beta 106B increases expression ISO Thalidomide results in increased expression of DEFB15 mRNA CTD PMID:26217789 NCBI chr 8:7,482,504...7,486,400
Ensembl chr 8:7,482,504...7,486,400
Ensembl chr 8:7,482,504...7,486,400 		JBrowse link
G DES desmin multiple interactions ISO Thalidomide inhibits the reaction [Carbon Tetrachloride results in increased expression of DES protein] CTD PMID:17030452 NCBI chr 2:219,418,377...219,426,734
Ensembl chr 2:219,418,377...219,426,735 		JBrowse link
G DEXI Dexi homolog increases expression ISO Thalidomide results in increased expression of DEXI mRNA CTD PMID:26217789 NCBI chr16:10,928,891...10,942,468
Ensembl chr16:10,928,891...10,942,468 		JBrowse link
G DLGAP5 DLG associated protein 5 decreases expression ISO Thalidomide results in decreased expression of DLGAP5 mRNA CTD PMID:26217789 NCBI chr14:55,148,135...55,191,585
Ensembl chr14:55,148,112...55,191,608 		JBrowse link
G DLK1 delta like non-canonical Notch ligand 1 decreases expression ISO Thalidomide results in decreased expression of DLK1 mRNA CTD PMID:26217789 NCBI chr14:100,726,892...100,738,224
Ensembl chr14:100,725,705...100,738,224 		JBrowse link
G DNAJB1 DnaJ heat shock protein family (Hsp40) member B1 increases expression EXP Thalidomide analog results in increased expression of DNAJB1 mRNA CTD PMID:20525221 NCBI chr19:14,514,769...14,560,391
Ensembl chr19:14,514,769...14,560,391 		JBrowse link
G DNAJB4 DnaJ heat shock protein family (Hsp40) member B4 increases expression EXP Thalidomide analog results in increased expression of DNAJB4 mRNA CTD PMID:20525221 NCBI chr 1:77,979,175...78,017,964
Ensembl chr 1:77,979,175...78,017,964 		JBrowse link
G DNAJB9 DnaJ heat shock protein family (Hsp40) member B9 increases expression EXP Thalidomide analog results in increased expression of DNAJB9 mRNA CTD PMID:20525221 NCBI chr 7:108,569,874...108,574,850
Ensembl chr 7:108,569,867...108,574,850 		JBrowse link
G DNAJC19 DnaJ heat shock protein family (Hsp40) member C19 decreases expression ISO Thalidomide results in decreased expression of DNAJC19 mRNA CTD PMID:26217789 NCBI chr 3:180,983,709...180,989,838
Ensembl chr 3:180,983,697...180,989,774 		JBrowse link
G DUS4L dihydrouridine synthase 4 like decreases expression ISO Thalidomide results in decreased expression of DUS4L mRNA CTD PMID:26217789 NCBI chr 7:107,563,971...107,578,523
Ensembl chr 7:107,563,484...107,578,523 		JBrowse link
G DUSP1 dual specificity phosphatase 1 increases expression EXP Thalidomide analog results in increased expression of DUSP1 mRNA CTD PMID:20525221 NCBI chr 5:172,768,096...172,771,195
Ensembl chr 5:172,768,096...172,771,195 		JBrowse link
G DUSP10 dual specificity phosphatase 10 increases expression EXP Thalidomide analog results in increased expression of DUSP10 mRNA CTD PMID:20525221 NCBI chr 1:221,701,424...221,742,089
Ensembl chr 1:221,701,424...221,742,089 		JBrowse link
G DUSP8 dual specificity phosphatase 8 increases expression EXP Thalidomide analog results in increased expression of DUSP8 mRNA CTD PMID:20525221 NCBI chr11:1,554,051...1,572,848
Ensembl chr11:1,554,051...1,572,271 		JBrowse link
G EEF1E1 eukaryotic translation elongation factor 1 epsilon 1 decreases expression ISO Thalidomide results in decreased expression of EEF1E1 mRNA CTD PMID:26217789 NCBI chr 6:8,073,360...8,102,548
Ensembl chr 6:8,073,360...8,102,559 		JBrowse link
G EFCAB2 EF-hand calcium binding domain 2 decreases expression ISO Thalidomide results in decreased expression of EFCAB2 mRNA CTD PMID:26217789 NCBI chr 1:244,969,682...245,125,229
Ensembl chr 1:244,969,682...245,127,164 		JBrowse link
G EIF1B eukaryotic translation initiation factor 1B decreases expression ISO Thalidomide results in decreased expression of EIF1B mRNA CTD PMID:26217789 NCBI chr 3:40,309,707...40,312,424
Ensembl chr 3:40,309,707...40,312,424 		JBrowse link
G EIF4E eukaryotic translation initiation factor 4E decreases expression ISO Thalidomide results in decreased expression of EIF4E protein CTD PMID:18291259 NCBI chr 4:98,879,276...98,929,133
Ensembl chr 4:98,879,276...98,929,133 		JBrowse link
G ELANE elastase, neutrophil expressed multiple interactions EXP Thalidomide inhibits the reaction [Lipopolysaccharides results in increased secretion of ELANE protein]; Thalidomide inhibits the reaction [lipoteichoic acid results in increased secretion of ELANE protein] CTD PMID:11302825 NCBI chr19:852,303...856,243
Ensembl chr19:851,014...856,247 		JBrowse link
G EMC8 ER membrane protein complex subunit 8 decreases expression ISO Thalidomide results in decreased expression of EMC8 mRNA CTD PMID:26217789 NCBI chr16:85,778,624...85,799,544
Ensembl chr16:85,771,758...85,799,608 		JBrowse link
G EPHA10 EPH receptor A10 decreases expression EXP Thalidomide results in decreased expression of EPHA10 mRNA CTD PMID:32756504 NCBI chr 1:37,713,880...37,765,120
Ensembl chr 1:37,713,880...37,765,133 		JBrowse link
G EPHB1 EPH receptor B1 decreases expression EXP Thalidomide results in decreased expression of EPHB1 mRNA CTD PMID:32756504 NCBI chr 3:134,795,260...135,260,467
Ensembl chr 3:134,795,260...135,260,467 		JBrowse link
G ERBB2 erb-b2 receptor tyrosine kinase 2 multiple interactions EXP [ERBB2 protein co-treated with PIK3CA protein mutant form] results in increased susceptibility to Thalidomide metabolite CTD PMID:28745489 NCBI chr17:39,688,094...39,728,658
Ensembl chr17:39,687,914...39,730,426 		JBrowse link
G ESD esterase D decreases expression ISO Thalidomide results in decreased expression of ESD mRNA CTD PMID:26217789 NCBI chr13:46,771,256...46,797,700
Ensembl chr13:46,771,256...46,797,420 		JBrowse link
G EYA1 EYA transcriptional coactivator and phosphatase 1 decreases expression EXP Thalidomide results in decreased expression of EYA1 mRNA CTD PMID:31711903 NCBI chr 8:71,197,433...71,548,094
Ensembl chr 8:71,197,433...71,592,025 		JBrowse link
G F2R coagulation factor II thrombin receptor decreases expression EXP Thalidomide results in decreased expression of F2R mRNA; Thalidomide results in decreased expression of F2R protein CTD PMID:15618473 NCBI chr 5:76,716,126...76,735,770
Ensembl chr 5:76,716,126...76,735,770 		JBrowse link
G FABP5 fatty acid binding protein 5 decreases expression ISO Thalidomide results in decreased expression of FABP5 mRNA CTD PMID:26217789 NCBI chr 8:81,280,536...81,284,775
Ensembl chr 8:81,280,536...81,284,777 		JBrowse link
G FABP7 fatty acid binding protein 7 affects expression ISO Thalidomide affects the expression of FABP7 mRNA CTD PMID:26217789 NCBI chr 6:122,749,201...122,784,074
Ensembl chr 6:122,779,716...122,784,074 		JBrowse link
G FAM174B family with sequence similarity 174 member B decreases expression ISO Thalidomide results in decreased expression of FAM174B mRNA CTD PMID:26217789 NCBI chr15:92,617,448...92,655,775
Ensembl chr15:92,617,448...92,809,884 		JBrowse link
G FAS Fas cell surface death receptor decreases expression
increases expression		 EXP
ISO		 Thalidomide results in decreased expression of FAS protein
Thalidomide results in increased expression of FAS mRNA		 CTD PMID:16531263 PMID:18291259 NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605 		JBrowse link
G FASLG Fas ligand multiple interactions
decreases expression		 ISO
EXP		 Thalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of FASL mRNA]
Thalidomide results in decreased expression of FASLG protein		 CTD PMID:16510725 PMID:16531263 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876 		JBrowse link
G FEN1 flap structure-specific endonuclease 1 multiple interactions EXP [Azacitidine co-treated with Thalidomide] affects the expression of FEN1 mRNA CTD PMID:18720364 NCBI chr11:61,792,911...61,797,238
Ensembl chr11:61,792,911...61,797,238 		JBrowse link
G FGD3 FYVE, RhoGEF and PH domain containing 3 increases expression ISO Thalidomide results in increased expression of FGD3 mRNA CTD PMID:26217789 NCBI chr 9:92,947,523...93,036,233
Ensembl chr 9:92,947,523...93,036,236 		JBrowse link
G FGD5-AS1 FGD5 antisense RNA 1 affects response to substance
decreases expression
multiple interactions		 EXP FGD5-AS1 affects the susceptibility to Thalidomide
Thalidomide results in decreased expression of FGD5-AS1 mRNA
FGD5-AS1 inhibits the reaction [Thalidomide results in decreased expression of and results in decreased secretion of VEGFA protein]; FGD5-AS1 inhibits the reaction [Thalidomide results in decreased expression of CD274 protein]; FGD5-AS1 inhibits the reaction [Thalidomide results in decreased expression of CDH2 protein]; FGD5-AS1 inhibits the reaction [Thalidomide results in decreased expression of ZEB1 protein]; FGD5-AS1 inhibits the reaction [Thalidomide results in increased expression of CDH1 protein]; MIR454 mRNA affects the reaction [FGD5-AS1 affects the susceptibility to Thalidomide]		 CTD PMID:34520751 NCBI chr 3:14,942,779...14,948,441
Ensembl chr 3:14,920,347...14,948,424 		JBrowse link
G FGF2 fibroblast growth factor 2 increases response to substance
decreases expression
multiple interactions
decreases activity
affects secretion
affects expression		 EXP
ISO		 FGF2 protein results in increased susceptibility to Thalidomide
Thalidomide results in decreased expression of FGF2 protein
[temozolomide co-treated with Thalidomide] results in decreased expression of FGF2 protein
Thalidomide results in decreased activity of FGF2 protein
Thalidomide promotes the reaction [FGF2 protein results in decreased expression of MMP2 protein]
Thalidomide affects the secretion of FGF2 protein
Thalidomide affects the expression of FGF2 mRNA; Thalidomide affects the expression of FGF2 protein		 CTD PMID:11555579 PMID:12644816 PMID:14558594 PMID:15863203 PMID:15939924 More... NCBI chr 4:122,826,682...122,898,236
Ensembl chr 4:122,826,682...122,898,236 		JBrowse link
G FGF8 fibroblast growth factor 8 increases expression EXP Thalidomide results in increased expression of FGF8 mRNA CTD PMID:31711903 NCBI chr10:101,770,109...101,780,369
Ensembl chr10:101,770,109...101,780,371 		JBrowse link
G FGFR1 fibroblast growth factor receptor 1 affects expression EXP Thalidomide affects the expression of FGFR1 mRNA CTD PMID:30834740 NCBI chr 8:38,411,143...38,468,635
Ensembl chr 8:38,400,215...38,468,834 		JBrowse link
G FGFR2 fibroblast growth factor receptor 2 decreases expression EXP Thalidomide results in decreased expression of FGFR2 mRNA; Thalidomide results in decreased expression of FGFR2 protein CTD PMID:30834740 NCBI chr10:121,478,330...121,598,458
Ensembl chr10:121,478,332...121,598,458 		JBrowse link
G FGFR3 fibroblast growth factor receptor 3 affects expression EXP Thalidomide affects the expression of FGFR3 mRNA CTD PMID:30834740 NCBI chr 4:1,793,293...1,808,867
Ensembl chr 4:1,793,293...1,808,872 		JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Thalidomide analog results in increased expression of FOS mRNA CTD PMID:20525221 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230 		JBrowse link
G FOSB FosB proto-oncogene, AP-1 transcription factor subunit increases expression EXP Thalidomide analog results in increased expression of FOSB mRNA CTD PMID:20525221 NCBI chr19:45,467,996...45,475,179
Ensembl chr19:45,467,995...45,475,179 		JBrowse link
G FOXC2 forkhead box C2 decreases expression EXP Thalidomide results in decreased expression of FOXC2 mRNA CTD PMID:31711903 NCBI chr16:86,566,829...86,569,728
Ensembl chr16:86,566,829...86,569,728 		JBrowse link
G FOXRED1 FAD dependent oxidoreductase domain containing 1 decreases expression ISO Thalidomide results in decreased expression of FOXRED1 mRNA CTD PMID:26217789 NCBI chr11:126,269,154...126,278,126
Ensembl chr11:126,269,024...126,278,131 		JBrowse link
G FZD8 frizzled class receptor 8 decreases expression EXP Thalidomide results in decreased expression of FZD8 mRNA CTD PMID:24154490 NCBI chr10:35,638,247...35,642,296
Ensembl chr10:35,638,247...35,642,296 		JBrowse link
G GAB3 GRB2 associated binding protein 3 decreases expression ISO Thalidomide results in decreased expression of GAB3 mRNA CTD PMID:26217789 NCBI chr  X:154,675,249...154,751,566
Ensembl chr  X:154,675,249...154,751,583 		JBrowse link
G GADD45B growth arrest and DNA damage inducible beta multiple interactions ISO Thalidomide inhibits the reaction [lipopolysaccharide A results in increased expression of GADD45B mRNA] CTD PMID:15797874 NCBI chr19:2,476,127...2,478,257
Ensembl chr19:2,476,122...2,478,259 		JBrowse link
G GALM galactose mutarotase decreases expression ISO Thalidomide results in decreased expression of GALM mRNA CTD PMID:26217789 NCBI chr 2:38,666,114...38,734,765
Ensembl chr 2:38,666,081...38,741,237 		JBrowse link
G GATA3 GATA binding protein 3 increases expression ISO Thalidomide results in increased expression of GATA3 protein CTD PMID:19428696 NCBI chr10:8,045,333...8,075,198
Ensembl chr10:8,045,378...8,075,198 		JBrowse link
G GCNT2 glucosaminyl (N-acetyl) transferase 2 (I blood group) decreases expression ISO Thalidomide results in decreased expression of GCNT2 mRNA CTD PMID:26217789 NCBI chr 6:10,521,351...10,629,368
Ensembl chr 6:10,492,223...10,629,368 		JBrowse link
G GEMIN2 gem nuclear organelle associated protein 2 decreases expression ISO Thalidomide results in decreased expression of GEMIN2 mRNA CTD PMID:26217789 NCBI chr14:39,114,323...39,136,973
Ensembl chr14:39,114,285...39,136,973 		JBrowse link
G GFRA2 GDNF family receptor alpha 2 decreases expression ISO Thalidomide results in decreased expression of GFRA2 mRNA CTD PMID:26217789 NCBI chr 8:21,690,398...21,812,345
Ensembl chr 8:21,690,398...21,812,357 		JBrowse link
G GOT1 glutamic-oxaloacetic transaminase 1 increases expression ISO Thalidomide results in increased expression of GOT1 mRNA CTD PMID:26217789 NCBI chr10:99,396,870...99,430,624
Ensembl chr10:99,396,870...99,430,624 		JBrowse link
G GP2 glycoprotein 2 increases expression ISO Thalidomide results in increased expression of GP2 mRNA CTD PMID:26217789 NCBI chr16:20,309,574...20,327,513
Ensembl chr16:20,309,574...20,327,808 		JBrowse link
G GPATCH4 G-patch domain containing 4 (gene/pseudogene) decreases expression ISO Thalidomide results in decreased expression of GPATCH4 mRNA CTD PMID:26217789 NCBI chr 1:156,594,301...156,601,479
Ensembl chr 1:156,594,301...156,601,496 		JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions ISO Thalidomide inhibits the reaction [Carbon Tetrachloride results in decreased activity of GPX1 protein] CTD PMID:17030452 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,174...49,358,605 		JBrowse link
G GPX8 glutathione peroxidase 8 (putative) decreases expression ISO Thalidomide results in decreased expression of GPX8 mRNA CTD PMID:26217789 NCBI chr 5:55,160,171...55,167,297
Ensembl chr 5:55,160,167...55,167,297 		JBrowse link
G GRIA3 glutamate ionotropic receptor AMPA type subunit 3 decreases expression EXP Thalidomide results in decreased expression of GRIA3 mRNA CTD PMID:32756504 NCBI chr  X:123,184,278...123,490,915
Ensembl chr  X:123,184,153...123,490,915 		JBrowse link
G GRIA4 glutamate ionotropic receptor AMPA type subunit 4 increases expression EXP Thalidomide results in increased expression of GRIA4 mRNA CTD PMID:32756504 NCBI chr11:105,609,616...105,982,090
Ensembl chr11:105,609,535...105,982,090 		JBrowse link
G GRIN2A glutamate ionotropic receptor NMDA type subunit 2A decreases expression EXP Thalidomide results in decreased expression of GRIN2A mRNA CTD PMID:32756504 NCBI chr16:9,753,404...10,182,908
Ensembl chr16:9,753,404...10,182,928 		JBrowse link
G GRIN2C glutamate ionotropic receptor NMDA type subunit 2C decreases expression EXP Thalidomide results in decreased expression of GRIN2C mRNA CTD PMID:32756504 NCBI chr17:74,842,023...74,861,532
Ensembl chr17:74,842,023...74,861,504 		JBrowse link
G GTF2E1 general transcription factor IIE subunit 1 decreases expression ISO Thalidomide results in decreased expression of GTF2E1 mRNA CTD PMID:26217789 NCBI chr 3:120,742,744...120,783,069
Ensembl chr 3:120,742,637...120,783,069 		JBrowse link
G GULP1 GULP PTB domain containing engulfment adaptor 1 decreases expression ISO Thalidomide results in decreased expression of GULP1 mRNA CTD PMID:26217789 NCBI chr 2:188,291,874...188,595,926
Ensembl chr 2:188,291,669...188,595,931 		JBrowse link
G H2AC15 H2A clustered histone 15 decreases expression ISO Thalidomide results in decreased expression of H2AC15 mRNA CTD PMID:26217789 NCBI chr 6:27,837,880...27,838,375
Ensembl chr 6:27,837,880...27,838,375 		JBrowse link
G H2BC12 H2B clustered histone 12 decreases expression ISO Thalidomide results in decreased expression of H2BC12 mRNA CTD PMID:26217789 NCBI chr 6:27,138,293...27,146,858
Ensembl chr 6:27,146,361...27,146,855 		JBrowse link
G H2BC27P H2B clustered histone 27, pseudogene decreases expression ISO Thalidomide results in decreased expression of H2BC27 mRNA CTD PMID:26217789 NCBI chr 1:228,464,170...228,464,575
Ensembl chr 1:228,464,213...228,464,594 		JBrowse link
G H2BC4 H2B clustered histone 4 decreases expression ISO Thalidomide results in decreased expression of H2BC4 mRNA CTD PMID:26217789 NCBI chr 6:26,113,170...26,123,926
Ensembl chr 6:26,086,317...26,123,926 		JBrowse link
G H3C1 H3 clustered histone 1 decreases expression ISO Thalidomide results in decreased expression of H3C1 mRNA CTD PMID:26217789 NCBI chr 6:26,020,451...26,020,958
Ensembl chr 6:26,020,451...26,020,958 		JBrowse link
G H3C15 H3 clustered histone 15 decreases expression ISO Thalidomide results in decreased expression of H3C15 mRNA CTD PMID:26217789 NCBI chr 1:149,852,608...149,853,125
Ensembl chr 1:149,852,608...149,853,125 		JBrowse link
G H4C11 H4 clustered histone 11 decreases expression ISO Thalidomide results in decreased expression of H4C11 mRNA CTD PMID:26217789 NCBI chr 6:27,824,092...27,824,480
Ensembl chr 6:27,824,092...27,824,480 		JBrowse link
G H4C14 H4 clustered histone 14 decreases expression ISO Thalidomide results in decreased expression of H4C14 mRNA CTD PMID:26217789 NCBI chr 1:149,832,657...149,833,052
Ensembl chr 1:149,832,657...149,839,767 		JBrowse link
G H4C3 H4 clustered histone 3 decreases expression ISO Thalidomide results in decreased expression of H4C3 mRNA; Thalidomide results in decreased expression of H4C4 mRNA CTD PMID:26217789 NCBI chr 6:26,103,933...26,104,337
Ensembl chr 6:26,103,933...26,104,337 		JBrowse link
G HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 decreases expression ISO Thalidomide results in decreased expression of HCN1 mRNA CTD PMID:26217789 NCBI chr 5:45,254,948...45,696,380
Ensembl chr 5:45,254,948...45,696,498 		JBrowse link
G HERPUD1 homocysteine inducible ER protein with ubiquitin like domain 1 increases expression EXP Thalidomide analog results in increased expression of HERPUD1 mRNA CTD PMID:20525221 NCBI chr16:56,932,142...56,944,864
Ensembl chr16:56,932,142...56,944,864 		JBrowse link
G HGF hepatocyte growth factor affects expression
affects secretion
decreases activity		 EXP Thalidomide affects the expression of HGF mRNA; Thalidomide affects the expression of HGF protein
Thalidomide affects the secretion of HGF protein
Thalidomide results in decreased activity of HGF protein		 CTD PMID:15939924 PMID:17557286 NCBI chr 7:81,699,010...81,770,047
Ensembl chr 7:81,699,010...81,770,438 		JBrowse link
G HIRIP3 HIRA interacting protein 3 decreases expression ISO Thalidomide results in decreased expression of HIRIP3 mRNA CTD PMID:26217789 NCBI chr16:29,992,321...29,996,096
Ensembl chr16:29,992,330...29,996,074 		JBrowse link
G HLA-A major histocompatibility complex, class I, A increases expression ISO Thalidomide results in increased expression of H2-Q1 mRNA CTD PMID:26217789 NCBI chr 6:29,942,532...29,945,870
Ensembl chr 6:29,941,260...29,949,572 		JBrowse link
G HLA-E major histocompatibility complex, class I, E affects expression EXP Thalidomide affects the expression of HLA-E mRNA CTD PMID:25811541 NCBI chr 6:30,489,509...30,494,194
Ensembl chr 6:30,489,509...30,494,194 		JBrowse link
G HMGN5 high mobility group nucleosome binding domain 5 decreases expression ISO Thalidomide results in decreased expression of HMGN5 mRNA CTD PMID:26217789 NCBI chr  X:81,113,699...81,201,913
Ensembl chr  X:81,113,699...81,201,913 		JBrowse link
G HOXB7 homeobox B7 increases expression EXP Thalidomide results in increased expression of HOXB7 mRNA CTD PMID:31711903 NCBI chr17:48,607,232...48,611,017
Ensembl chr17:48,607,232...48,633,572 		JBrowse link
G HOXB9 homeobox B9 increases expression EXP Thalidomide results in increased expression of HOXB9 mRNA CTD PMID:31711903 NCBI chr17:48,621,156...48,626,358
Ensembl chr17:48,621,156...48,626,358 		JBrowse link
G HSD11B2 hydroxysteroid 11-beta dehydrogenase 2 decreases expression ISO Thalidomide results in decreased expression of HSD11B2 mRNA CTD PMID:26217789 NCBI chr16:67,429,801...67,437,553
Ensembl chr16:67,430,652...67,437,553 		JBrowse link
G HSF1 heat shock transcription factor 1 decreases expression ISO Thalidomide results in decreased expression of HSF1 mRNA CTD PMID:26006729 PMID:26217789 NCBI chr 8:144,291,604...144,314,720
Ensembl chr 8:144,291,591...144,314,720 		JBrowse link
G HSPB1 heat shock protein family B (small) member 1 decreases expression ISO Thalidomide results in decreased expression of HSPB1 mRNA CTD PMID:26217789 NCBI chr 7:76,302,673...76,304,292
Ensembl chr 7:76,302,673...76,304,295 		JBrowse link
G HSPH1 heat shock protein family H (Hsp110) member 1 increases expression EXP Thalidomide analog results in increased expression of HSPH1 mRNA CTD PMID:20525221 NCBI chr13:31,134,973...31,162,388
Ensembl chr13:31,134,973...31,162,388 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 increases response to substance
decreases expression		 EXP
ISO		 ICAM1 gene SNP results in increased susceptibility to Thalidomide
Thalidomide results in decreased expression of ICAM1 mRNA; Thalidomide results in decreased expression of ICAM1 protein		 CTD PMID:17174718 PMID:21245421 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615 		JBrowse link
G IDNK IDNK gluconokinase decreases expression ISO Thalidomide results in decreased expression of IDNK mRNA CTD PMID:26217789 NCBI chr 9:83,623,006...83,644,123
Ensembl chr 9:83,623,049...83,644,130 		JBrowse link
G IFNG interferon gamma multiple interactions
decreases expression
increases expression
affects expression		 ISO
EXP		 [Thalidomide co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG protein
Thalidomide results in decreased expression of IFNG protein
Thalidomide inhibits the reaction [irinotecan results in increased expression of IFNG protein]; Thalidomide promotes the reaction [irinotecan results in increased expression of IFNG protein]
Thalidomide results in increased expression of IFNG; Thalidomide results in increased expression of IFNG protein
Thalidomide affects the expression of IFNG mRNA		 CTD PMID:15588918 PMID:16078585 PMID:16454849 PMID:16514283 PMID:16815871 More... NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IFT27 intraflagellar transport 27 decreases expression ISO Thalidomide results in decreased expression of IFT27 mRNA CTD PMID:26006729 PMID:26217789 NCBI chr22:36,758,211...36,776,119
Ensembl chr22:36,758,202...36,776,256 		JBrowse link
G IFT70A intraflagellar transport 70A decreases expression ISO Thalidomide results in decreased expression of IFT70A1 mRNA CTD PMID:26217789 NCBI chr 2:177,612,999...177,618,742
Ensembl chr 2:177,612,999...177,618,742 		JBrowse link
G IFT74 intraflagellar transport 74 decreases expression ISO Thalidomide results in decreased expression of IFT74 mRNA CTD PMID:26217789 NCBI chr 9:26,947,110...27,066,134
Ensembl chr 9:26,947,039...27,066,134 		JBrowse link
G IGF1 insulin like growth factor 1 affects expression EXP Thalidomide affects the expression of IGF1 mRNA CTD PMID:15939924 NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744 		JBrowse link
G IGFBP3 insulin like growth factor binding protein 3 affects expression
decreases expression		 EXP
ISO		 Thalidomide affects the expression of IGFBP3 mRNA
Thalidomide results in decreased expression of IGFBP3 mRNA		 CTD PMID:15939924 PMID:26217789 NCBI chr 7:45,912,245...45,921,272
Ensembl chr 7:45,912,245...45,921,874 		JBrowse link
G IL10 interleukin 10 affects expression
decreases expression		 EXP
ISO		 Thalidomide affects the expression of IL10 mRNA
Thalidomide results in decreased expression of IL10 protein		 CTD PMID:16454849 PMID:16514283 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G IL12A interleukin 12A multiple interactions EXP Thalidomide results in decreased expression of [IL12A protein binds to IL12B protein] CTD PMID:11788559 NCBI chr 3:159,988,835...159,996,019
Ensembl chr 3:159,988,835...159,996,019 		JBrowse link
G IL12B interleukin 12B multiple interactions EXP
ISO		 Thalidomide results in decreased expression of [IL12A protein binds to IL12B protein]
Thalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of IL12B mRNA]		 CTD PMID:11788559 PMID:16510725 NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,863 		JBrowse link
G IL18 interleukin 18 increases expression ISO Thalidomide results in increased expression of IL18 CTD PMID:17089043 NCBI chr11:112,143,260...112,164,094
Ensembl chr11:112,143,253...112,164,096 		JBrowse link
G IL1B interleukin 1 beta decreases expression
multiple interactions		 EXP
ISO		 Thalidomide results in decreased expression of IL1B protein
Thalidomide inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of IL1B protein]; Thalidomide inhibits the reaction [Paraquat results in increased expression of IL1B mRNA]
Thalidomide inhibits the reaction [Irinotecan results in increased expression of IL1B protein]; Thalidomide promotes the reaction [Irinotecan results in increased expression of IL1B protein]		 CTD PMID:15863203 PMID:16815871 PMID:23510834 PMID:25478868 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL1R1 interleukin 1 receptor type 1 decreases expression EXP Thalidomide results in decreased expression of IL1R1 mRNA CTD PMID:15618473 NCBI chr 2:102,070,390...102,179,874
Ensembl chr 2:102,064,544...102,179,874 		JBrowse link
G IL1RN interleukin 1 receptor antagonist multiple interactions ISO Thalidomide promotes the reaction [SOD1 gene mutant form results in increased expression of IL1RN mRNA] CTD PMID:16510725 NCBI chr 2:113,099,360...113,134,014
Ensembl chr 2:113,099,315...113,134,016 		JBrowse link
G IL2 interleukin 2 multiple interactions
decreases expression		 ISO [Thalidomide co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 protein
Thalidomide inhibits the reaction [irinotecan results in decreased expression of IL2 protein]; Thalidomide promotes the reaction [irinotecan results in decreased expression of IL2 protein]
Thalidomide results in decreased expression of IL2 protein		 CTD PMID:15588918 PMID:16815871 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725 		JBrowse link
G IL4 interleukin 4 increases expression ISO Thalidomide results in increased expression of IL4 protein CTD PMID:16078585 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678 		JBrowse link
G IL6 interleukin 6 decreases secretion
multiple interactions
decreases activity		 EXP
ISO		 Thalidomide analog results in decreased secretion of IL6 protein
Thalidomide inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of IL6 protein]; Thalidomide inhibits the reaction [Paraquat results in increased expression of IL6 mRNA]
Thalidomide inhibits the reaction [irinotecan results in increased expression of IL6 protein]; Thalidomide inhibits the reaction [Paraquat results in increased expression of IL6 mRNA]; Thalidomide inhibits the reaction [Paraquat results in increased expression of IL6 protein]
Thalidomide results in decreased activity of IL6 protein		 CTD PMID:15858615 PMID:16815871 PMID:17557286 PMID:23510834 PMID:25478868 More... NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G IL6ST interleukin 6 cytokine family signal transducer decreases expression EXP Thalidomide results in decreased expression of IL6ST mRNA CTD PMID:15618473 NCBI chr 5:55,935,095...55,994,963
Ensembl chr 5:55,935,095...55,995,022 		JBrowse link
G ING3 inhibitor of growth family member 3 increases expression EXP Thalidomide analog results in increased expression of ING3 mRNA CTD PMID:20525221 NCBI chr 7:120,950,777...120,977,216
Ensembl chr 7:120,950,763...120,977,216 		JBrowse link
G IPP intracisternal A particle-promoted polypeptide decreases expression ISO Thalidomide results in decreased expression of IPP mRNA CTD PMID:26217789 NCBI chr 1:45,694,324...45,750,653
Ensembl chr 1:45,694,324...45,750,653 		JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit increases expression EXP Thalidomide analog results in increased expression of JUN mRNA CTD PMID:20525221 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048 		JBrowse link
G KALRN kalirin RhoGEF kinase decreases expression EXP Thalidomide results in decreased expression of KALRN mRNA CTD PMID:32756504 NCBI chr 3:124,033,369...124,726,325
Ensembl chr 3:124,033,369...124,726,325 		JBrowse link
G KDR kinase insert domain receptor multiple interactions EXP sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of KDR mRNA] CTD PMID:15741222 NCBI chr 4:55,078,481...55,125,595
Ensembl chr 4:55,078,481...55,125,595 		JBrowse link
G KIF2C kinesin family member 2C multiple interactions EXP [Azacitidine co-treated with Thalidomide] affects the expression of KIF2C mRNA CTD PMID:18720364 NCBI chr 1:44,739,837...44,767,767
Ensembl chr 1:44,739,818...44,767,767 		JBrowse link
G KLHL4 kelch like family member 4 decreases expression ISO Thalidomide results in decreased expression of KLHL4 mRNA CTD PMID:26217789 NCBI chr  X:87,517,802...87,670,050
Ensembl chr  X:87,517,409...87,670,050 		JBrowse link
G KLK1 kallikrein 1 decreases expression ISO Thalidomide results in decreased expression of KLK1 mRNA CTD PMID:26217789 NCBI chr19:50,819,146...50,823,787
Ensembl chr19:50,819,146...50,823,787 		JBrowse link
G KLK3 kallikrein related peptidase 3 decreases expression EXP Thalidomide results in decreased expression of KLK3 protein CTD PMID:12644816 NCBI chr19:50,854,915...50,860,764
Ensembl chr19:50,854,915...50,860,764 		JBrowse link
G KRTAP1-5 keratin associated protein 1-5 increases expression ISO Thalidomide results in increased expression of KRTAP1-4 mRNA CTD PMID:26217789 NCBI chr17:41,026,026...41,027,208
Ensembl chr17:41,026,026...41,027,208 		JBrowse link
G LATS2 large tumor suppressor kinase 2 increases expression EXP Thalidomide analog results in increased expression of LATS2 mRNA CTD PMID:20525221 NCBI chr13:20,973,036...21,061,586
Ensembl chr13:20,973,036...21,061,586 		JBrowse link
G LEFTY2 left-right determination factor 2 decreases expression ISO Thalidomide results in decreased expression of LEFTY2 mRNA CTD PMID:26217789 NCBI chr 1:225,936,603...225,941,220
Ensembl chr 1:225,936,598...225,941,383 		JBrowse link
G LRR1 leucine rich repeat protein 1 decreases expression ISO Thalidomide results in decreased expression of LRR1 mRNA CTD PMID:26217789 NCBI chr14:49,598,940...49,614,672
Ensembl chr14:49,598,761...49,614,672 		JBrowse link
G LTF lactotransferrin multiple interactions EXP Thalidomide inhibits the reaction [Lipopolysaccharides results in increased secretion of LTF protein]; Thalidomide inhibits the reaction [lipoteichoic acid results in increased secretion of LTF protein] CTD PMID:11302825 NCBI chr 3:46,435,645...46,485,234
Ensembl chr 3:46,435,645...46,485,234 		JBrowse link
G LY96 lymphocyte antigen 96 decreases expression ISO Thalidomide results in decreased expression of LY96 mRNA CTD PMID:26006729 PMID:26217789 NCBI chr 8:73,991,392...74,099,857
Ensembl chr 8:73,991,392...74,029,079 		JBrowse link
G LYRM2 LYR motif containing 2 decreases expression ISO Thalidomide results in decreased expression of LYRM2 mRNA CTD PMID:26217789 NCBI chr 6:89,632,224...89,638,747
Ensembl chr 6:89,568,144...89,638,749 		JBrowse link
G LYRM4 LYR motif containing 4 decreases expression ISO Thalidomide results in decreased expression of LYRM4 mRNA CTD PMID:26217789 NCBI chr 6:5,031,753...5,260,950
Ensembl chr 6:5,103,629...5,260,950 		JBrowse link
G MAP1LC3B microtubule associated protein 1 light chain 3 beta multiple interactions EXP Thalidomide promotes the reaction [temozolomide results in increased expression of MAP1LC3B protein] CTD PMID:19567134 NCBI chr16:87,392,336...87,404,774
Ensembl chr16:87,383,953...87,404,779 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation EXP Thalidomide analog results in increased phosphorylation of MAPK1 protein CTD PMID:15858615 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK14 mitogen-activated protein kinase 14 increases phosphorylation EXP Thalidomide analog results in increased phosphorylation of MAPK14 protein CTD PMID:15858615 NCBI chr 6:36,027,808...36,124,214
Ensembl chr 6:36,027,782...36,111,236 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation EXP Thalidomide analog results in increased phosphorylation of MAPK3 protein CTD PMID:15858615 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MCL1 MCL1 apoptosis regulator, BCL2 family member decreases expression EXP Thalidomide analog results in decreased expression of MCL1 protein CTD PMID:15858615 NCBI chr 1:150,574,558...150,579,610
Ensembl chr 1:150,560,895...150,579,738 		JBrowse link
G MCM5 minichromosome maintenance complex component 5 multiple interactions EXP [Azacitidine co-treated with Thalidomide] affects the expression of MCM5 mRNA CTD PMID:18720364 NCBI chr22:35,400,140...35,455,031
Ensembl chr22:35,400,134...35,425,431 		JBrowse link
G MEIS2 Meis homeobox 2 multiple interactions EXP Thalidomide inhibits the reaction [CRBN protein binds to and results in increased ubiquitination of and results in increased degradation of MEIS2 protein] CTD PMID:25043012 NCBI chr15:36,889,204...37,101,311
Ensembl chr15:36,889,204...37,101,299 		JBrowse link
G MEOX1 mesenchyme homeobox 1 decreases expression EXP Thalidomide results in decreased expression of MEOX1 mRNA CTD PMID:31711903 NCBI chr17:43,640,389...43,661,922
Ensembl chr17:43,640,389...43,661,922 		JBrowse link
G MESP2 mesoderm posterior bHLH transcription factor 2 decreases expression EXP Thalidomide results in decreased expression of MESP2 mRNA CTD PMID:31711903 NCBI chr15:89,776,332...89,778,754
Ensembl chr15:89,760,591...89,778,754 		JBrowse link
G METTL5 methyltransferase 5, N6-adenosine decreases expression ISO Thalidomide results in decreased expression of METTL5 mRNA CTD PMID:26217789 NCBI chr 2:169,811,757...169,824,905
Ensembl chr 2:169,810,081...169,824,931 		JBrowse link
G MIR301B microRNA 301b increases expression ISO Thalidomide results in increased expression of MIR301B mRNA CTD PMID:26217789 NCBI chr22:21,652,981...21,653,058
Ensembl chr22:21,652,981...21,653,058 		JBrowse link
G MIR30E microRNA 30e decreases expression ISO Thalidomide results in decreased expression of MIR30E mRNA CTD PMID:26217789 NCBI chr 1:40,754,355...40,754,446
Ensembl chr 1:40,754,355...40,754,446 		JBrowse link
G MIR449C microRNA 449c increases expression ISO Thalidomide results in increased expression of MIR449C mRNA CTD PMID:26217789 NCBI chr 5:55,172,262...55,172,353
Ensembl chr 5:55,172,262...55,172,353 		JBrowse link
G MIR454 microRNA 454 increases expression
multiple interactions		 EXP Thalidomide results in increased expression of MIR454 mRNA
MIR454 mRNA affects the reaction [FGD5-AS1 affects the susceptibility to Thalidomide]		 CTD PMID:34520751 NCBI chr17:59,137,758...59,137,872
Ensembl chr17:59,137,758...59,137,872 		JBrowse link
G MIXL1 Mix paired-like homeobox decreases expression ISO Thalidomide results in decreased expression of MIXL1 mRNA CTD PMID:26217789 NCBI chr 1:226,223,664...226,227,060
Ensembl chr 1:226,223,618...226,227,060 		JBrowse link
G MKI67 marker of proliferation Ki-67 multiple interactions
decreases expression		 EXP [Azacitidine co-treated with Thalidomide] affects the expression of MKI67 mRNA
Thalidomide results in decreased expression of MKI67 protein		 CTD PMID:18720364 PMID:34520751 NCBI chr10:128,096,659...128,126,423
Ensembl chr10:128,096,659...128,126,423 		JBrowse link
G MLF2 myeloid leukemia factor 2 decreases expression ISO Thalidomide results in decreased expression of MLF2 mRNA CTD PMID:26217789 NCBI chr12:6,747,996...6,753,141
Ensembl chr12:6,747,996...6,767,475 		JBrowse link
G MME membrane metalloendopeptidase decreases expression ISO Thalidomide results in decreased expression of MME mRNA CTD PMID:26217789 NCBI chr 3:155,024,202...155,183,729
Ensembl chr 3:155,024,124...155,183,704 		JBrowse link
G MMP2 matrix metallopeptidase 2 multiple interactions
decreases expression		 EXP Thalidomide promotes the reaction [FGF2 protein results in decreased expression of MMP2 protein]
Thalidomide results in decreased expression of MMP2 protein		 CTD PMID:14558594 PMID:15863203 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691 		JBrowse link
G MMP9 matrix metallopeptidase 9 decreases expression EXP Thalidomide results in decreased expression of MMP9 protein CTD PMID:15863203 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G MOXD1 monooxygenase DBH like 1 decreases expression ISO Thalidomide results in decreased expression of MOXD1 mRNA CTD PMID:26217789 NCBI chr 6:132,296,055...132,401,475
Ensembl chr 6:132,296,055...132,401,475 		JBrowse link
G MPO myeloperoxidase multiple interactions ISO Thalidomide inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of MPO protein]; Thalidomide inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:15138204 PMID:25478868 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935 		JBrowse link
G MPP1 MAGUK p55 scaffold protein 1 decreases expression ISO Thalidomide results in decreased expression of MPP1 mRNA CTD PMID:26217789 NCBI chr  X:154,778,684...154,805,485
Ensembl chr  X:154,778,684...154,821,007 		JBrowse link
G MRPL32 mitochondrial ribosomal protein L32 decreases expression ISO Thalidomide results in decreased expression of MRPL32 mRNA CTD PMID:26217789 NCBI chr 7:42,932,376...42,937,857
Ensembl chr 7:42,932,376...42,948,958 		JBrowse link
G MRPL34 mitochondrial ribosomal protein L34 decreases expression ISO Thalidomide results in decreased expression of MRPL34 mRNA CTD PMID:26217789 NCBI chr19:17,292,573...17,306,843
Ensembl chr19:17,292,609...17,306,843 		JBrowse link
G MRPL47 mitochondrial ribosomal protein L47 decreases expression ISO Thalidomide results in decreased expression of MRPL47 mRNA CTD PMID:26217789 NCBI chr 3:179,588,285...179,604,646
Ensembl chr 3:179,588,285...179,604,649 		JBrowse link
G MRPL52 mitochondrial ribosomal protein L52 decreases expression ISO Thalidomide results in decreased expression of MRPL52 mRNA CTD PMID:26217789 NCBI chr14:22,829,887...22,835,037
Ensembl chr14:22,829,879...22,835,037 		JBrowse link
G MRPS21 mitochondrial ribosomal protein S21 decreases expression ISO Thalidomide results in decreased expression of MRPS21 mRNA CTD PMID:26217789 NCBI chr 1:150,293,861...150,308,979
Ensembl chr 1:150,293,861...150,308,979 		JBrowse link
G MTFR2 mitochondrial fission regulator 2 decreases expression ISO Thalidomide results in decreased expression of MTFR2 mRNA CTD PMID:26217789 NCBI chr 6:136,231,034...136,250,311
Ensembl chr 6:136,231,024...136,250,335 		JBrowse link
G MYB MYB proto-oncogene, transcription factor multiple interactions
decreases phosphorylation
decreases activity		 EXP CAT protein inhibits the reaction [Thalidomide results in decreased activity of MYB protein]
Thalidomide results in decreased phosphorylation of MYB protein		 CTD PMID:16616857 NCBI chr 6:135,181,308...135,219,172
Ensembl chr 6:135,181,308...135,219,173 		JBrowse link
G MYBPC3 myosin binding protein C3 decreases expression ISO Thalidomide results in decreased expression of MYBPC3 mRNA CTD PMID:26006729 PMID:26217789 NCBI chr11:47,331,406...47,352,702
Ensembl chr11:47,331,406...47,352,702 		JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor decreases expression ISO Thalidomide results in decreased expression of MYD88 mRNA CTD PMID:26006729 PMID:26217789 NCBI chr 3:38,138,661...38,143,022
Ensembl chr 3:38,138,552...38,143,024 		JBrowse link
G MYH6 myosin heavy chain 6 affects expression ISO Thalidomide affects the expression of MYH6 mRNA CTD PMID:26006729 PMID:26217789 NCBI chr14:23,381,987...23,408,273
Ensembl chr14:23,381,982...23,408,273 		JBrowse link
G MYL3 myosin light chain 3 affects expression
decreases expression		 ISO Thalidomide affects the expression of MYL3 mRNA
Thalidomide results in decreased expression of MYL3 mRNA		 CTD PMID:26006729 PMID:26217789 NCBI chr 3:46,857,872...46,882,182
Ensembl chr 3:46,835,110...46,882,178 		JBrowse link
G MYL7 myosin light chain 7 decreases expression ISO Thalidomide results in decreased expression of MYL7 mRNA CTD PMID:26217789 NCBI chr 7:44,138,864...44,141,332
Ensembl chr 7:44,138,864...44,141,332 		JBrowse link
G MYLK myosin light chain kinase increases expression ISO Thalidomide results in increased expression of MYLK mRNA CTD PMID:26217789 NCBI chr 3:123,610,049...123,884,332
Ensembl chr 3:123,610,049...123,884,332 		JBrowse link
G MYOM1 myomesin 1 decreases expression ISO Thalidomide results in decreased expression of MYOM1 mRNA CTD PMID:26006729 PMID:26217789 NCBI chr18:3,066,807...3,247,376
Ensembl chr18:3,066,807...3,219,968 		JBrowse link
G NAA20 N-alpha-acetyltransferase 20, NatB catalytic subunit decreases expression ISO Thalidomide results in decreased expression of NAA20 mRNA CTD PMID:26217789 NCBI chr20:20,017,290...20,033,655
Ensembl chr20:20,017,310...20,033,655 		JBrowse link
G NANOG Nanog homeobox decreases expression ISO Thalidomide results in decreased expression of NANOG mRNA CTD PMID:26217789 NCBI chr12:7,789,402...7,799,146
Ensembl chr12:7,787,794...7,799,146 		JBrowse link
G NAXE NAD(P)HX epimerase decreases expression ISO Thalidomide results in decreased expression of NAXE mRNA CTD PMID:26217789 NCBI chr 1:156,591,776...156,594,299
Ensembl chr 1:156,591,756...156,609,507 		JBrowse link
G NDUFB8 NADH:ubiquinone oxidoreductase subunit B8 decreases expression ISO Thalidomide results in decreased expression of NDUFB8 mRNA CTD PMID:26217789 NCBI chr10:100,523,729...100,529,923
Ensembl chr10:100,523,740...100,530,000 		JBrowse link
G NEBL nebulette decreases expression ISO Thalidomide results in decreased expression of NEBL mRNA CTD PMID:26217789 NCBI chr10:20,779,973...21,293,050
Ensembl chr10:20,779,973...21,293,011 		JBrowse link
G NEUROD4 neuronal differentiation 4 increases expression ISO Thalidomide results in increased expression of NEUROD4 mRNA CTD PMID:26217789 NCBI chr12:55,019,974...55,030,017
Ensembl chr12:55,019,974...55,030,017 		JBrowse link
G NEUROG2 neurogenin 2 increases expression EXP Thalidomide results in increased expression of NEUROG2 mRNA CTD PMID:31711903 NCBI chr 4:112,513,516...112,516,180
Ensembl chr 4:112,513,516...112,516,180 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions ISO Thalidomide promotes the reaction [Paraquat results in increased expression of NFE2L2 mRNA]; Thalidomide promotes the reaction [Paraquat results in increased expression of NFE2L2 protein] CTD PMID:25579023 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions
decreases expression		 EXP
ISO		 [resveratrol co-treated with Thalidomide] results in decreased activity of [RELA protein binds to NFKB1 protein]
Thalidomide results in decreased expression of NFKB1 protein		 CTD PMID:16333628 PMID:17164350 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302 		JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions
increases expression		 EXP
ISO		 Thalidomide inhibits the reaction [TGFB1 protein results in increased degradation of NFKBIA protein]; Thalidomide inhibits the reaction [TGFB1 protein results in increased phosphorylation of NFKBIA protein]; Thalidomide inhibits the reaction [TGFB1 protein results in increased transport of NFKBIA protein]; Thalidomide inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
Thalidomide results in increased expression of NFKBIA protein
Thalidomide inhibits the reaction [Carbon Tetrachloride results in decreased expression of NFKBIA protein]; Thalidomide inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]		 CTD PMID:15687330 PMID:16288038 PMID:16604421 PMID:16943688 PMID:17174718 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749 		JBrowse link
G NHLH1 nescient helix-loop-helix 1 increases expression ISO Thalidomide results in increased expression of NHLH1 mRNA CTD PMID:26217789 NCBI chr 1:160,367,071...160,372,846
Ensembl chr 1:160,367,071...160,372,846 		JBrowse link
G NMS neuromedin S increases expression ISO Thalidomide results in increased expression of NMS mRNA CTD PMID:26217789 NCBI chr 2:100,470,482...100,483,280
Ensembl chr 2:100,470,482...100,483,280 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO Thalidomide inhibits the reaction [Dimethylnitrosamine results in increased expression of NOS2 mRNA] CTD PMID:16604421 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G NPPB natriuretic peptide B multiple interactions EXP [Thalidomide co-treated with Dexamethasone] results in increased expression of NPPB protein CTD PMID:18414984 NCBI chr 1:11,857,464...11,858,945
Ensembl chr 1:11,857,464...11,858,945 		JBrowse link
G NQO2 N-ribosyldihydronicotinamide:quinone dehydrogenase 2 decreases expression ISO Thalidomide results in decreased expression of NQO2 mRNA CTD PMID:26217789 NCBI chr 6:2,999,894...3,019,755
Ensembl chr 6:2,987,987...3,019,755 		JBrowse link
G NR1H5P nuclear receptor subfamily 1 group H member 5, pseudogene decreases expression ISO Thalidomide results in decreased expression of NR1H5 mRNA CTD PMID:26217789 NCBI chr 1:114,834,456...114,851,544
Ensembl chr 1:114,837,227...114,851,453 		JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases expression EXP Thalidomide results in increased expression of NR1I2 mRNA CTD PMID:28496040 NCBI chr 3:119,782,101...119,818,487
Ensembl chr 3:119,780,484...119,818,487 		JBrowse link
G NR4A1 nuclear receptor subfamily 4 group A member 1 increases expression EXP Thalidomide analog results in increased expression of NR4A1 mRNA CTD PMID:20525221 NCBI chr12:52,022,832...52,059,503
Ensembl chr12:52,022,832...52,059,507 		JBrowse link
G NR4A2 nuclear receptor subfamily 4 group A member 2 increases expression EXP Thalidomide analog results in increased expression of NR4A2 mRNA CTD PMID:20525221 NCBI chr 2:156,324,437...156,332,721
Ensembl chr 2:156,324,437...156,342,348 		JBrowse link
G NRP1 neuropilin 1 multiple interactions EXP sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of NRP1 mRNA] CTD PMID:15741222 NCBI chr10:33,177,493...33,334,667
Ensembl chr10:33,177,492...33,336,262 		JBrowse link
G NRP2 neuropilin 2 multiple interactions EXP sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of NRP2 mRNA] CTD PMID:15741222 NCBI chr 2:205,682,501...205,798,131
Ensembl chr 2:205,681,990...205,798,133 		JBrowse link
G NRXN1 neurexin 1 decreases expression EXP Thalidomide results in decreased expression of NRXN1 mRNA CTD PMID:32756504 NCBI chr 2:49,918,503...51,032,132
Ensembl chr 2:49,918,503...51,225,575 		JBrowse link
G NT5C3A 5'-nucleotidase, cytosolic IIIA decreases expression ISO Thalidomide results in decreased expression of NT5C3 mRNA CTD PMID:26217789 NCBI chr 7:33,014,113...33,062,776
Ensembl chr 7:33,014,130...33,062,796 		JBrowse link
G NT5E 5'-nucleotidase ecto decreases expression ISO Thalidomide results in decreased expression of NT5E mRNA CTD PMID:26217789 NCBI chr 6:85,450,083...85,495,784
Ensembl chr 6:85,449,584...85,495,791 		JBrowse link
G NTAN1 N-terminal asparagine amidase decreases expression ISO Thalidomide results in decreased expression of NTAN1 mRNA CTD PMID:26217789 NCBI chr16:15,037,857...15,056,074
Ensembl chr16:15,037,854...15,056,079 		JBrowse link
G NUDT14 nudix hydrolase 14 decreases expression ISO Thalidomide results in decreased expression of NUDT14 mRNA CTD PMID:26217789 NCBI chr14:105,172,939...105,181,312
Ensembl chr14:105,172,938...105,181,323 		JBrowse link
G NUDT22 nudix hydrolase 22 decreases expression ISO Thalidomide results in decreased expression of NUDT22 mRNA CTD PMID:26217789 NCBI chr11:64,226,258...64,230,269
Ensembl chr11:64,225,941...64,230,686 		JBrowse link
G NUP62CL nucleoporin 62 C-terminal like decreases expression ISO Thalidomide results in decreased expression of NUP62CL mRNA CTD PMID:26217789 NCBI chr  X:107,123,427...107,206,433
Ensembl chr  X:107,123,427...107,206,433 		JBrowse link
G NUSAP1 nucleolar and spindle associated protein 1 multiple interactions EXP [Azacitidine co-treated with Thalidomide] affects the expression of NUSAP1 mRNA CTD PMID:18720364 NCBI chr15:41,332,881...41,381,046
Ensembl chr15:41,320,794...41,381,050 		JBrowse link
G OAS1 2'-5'-oligoadenylate synthetase 1 decreases expression ISO Thalidomide results in decreased expression of OAS1G mRNA CTD PMID:26217789 NCBI chr12:112,906,962...112,933,219
Ensembl chr12:112,905,856...112,933,219 		JBrowse link
G OCLN occludin multiple interactions ISO Thalidomide inhibits the reaction [dinitrobenzenesulfonic acid results in decreased expression of OCLN protein] CTD PMID:16680017 NCBI chr 5:69,492,547...69,558,104
Ensembl chr 5:69,492,292...69,558,104 		JBrowse link
G OLIG2 oligodendrocyte transcription factor 2 increases expression ISO Thalidomide results in increased expression of OLIG2 mRNA CTD PMID:26217789 NCBI chr21:33,025,935...33,029,185
Ensembl chr21:33,025,935...33,029,196 		JBrowse link
G OLIG3 oligodendrocyte transcription factor 3 increases expression EXP Thalidomide results in increased expression of OLIG3 mRNA CTD PMID:31711903 NCBI chr 6:137,492,199...137,494,394
Ensembl chr 6:137,492,199...137,494,394 		JBrowse link
G OR10Q1 olfactory receptor family 10 subfamily Q member 1 increases expression ISO Thalidomide results in increased expression of OR10Q1 mRNA CTD PMID:26217789 NCBI chr11:58,227,882...58,228,918
Ensembl chr11:58,227,882...58,228,918 		JBrowse link
G OR1D2 olfactory receptor family 1 subfamily D member 2 increases expression ISO Thalidomide results in increased expression of OR1D2 mRNA CTD PMID:26217789 NCBI chr17:3,088,484...3,104,422
Ensembl chr17:3,088,484...3,104,422 		JBrowse link
G OR2AG1 olfactory receptor family 2 subfamily AG member 1 increases expression ISO Thalidomide results in increased expression of OR2AG1 mRNA CTD PMID:26217789 NCBI chr11:6,783,020...6,791,558
Ensembl chr11:6,783,020...6,791,558 		JBrowse link
G OR2Y1 olfactory receptor family 2 subfamily Y member 1 increases expression ISO Thalidomide results in increased expression of OR2Y1 mRNA CTD PMID:26217789 NCBI chr 5:180,739,123...180,740,058
Ensembl chr 5:180,739,123...180,740,058 		JBrowse link
G OR51Q1 olfactory receptor family 51 subfamily Q member 1 increases expression ISO Thalidomide results in increased expression of OR51Q1 mRNA CTD PMID:26217789 NCBI chr11:5,422,111...5,423,206
Ensembl chr11:5,422,111...5,423,206 		JBrowse link
G OR5I1 olfactory receptor family 5 subfamily I member 1 increases expression ISO Thalidomide results in increased expression of OR5I1 mRNA CTD PMID:26217789 NCBI chr11:55,935,456...55,936,400
Ensembl chr11:55,935,456...55,936,400 		JBrowse link
G OR5V1 olfactory receptor family 5 subfamily V member 1 increases expression ISO Thalidomide results in increased expression of OR5V1 mRNA CTD PMID:26217789 NCBI chr 6:29,353,749...29,368,865
Ensembl chr 6:29,353,749...29,431,967 		JBrowse link
G OR8A1 olfactory receptor family 8 subfamily A member 1 decreases expression ISO Thalidomide results in decreased expression of OR8A1B mRNA CTD PMID:26217789 NCBI chr11:124,569,997...124,571,374
Ensembl chr11:124,566,660...124,582,942 		JBrowse link
G OR8B3 olfactory receptor family 8 subfamily B member 3 increases expression ISO Thalidomide results in increased expression of OR8B3 mRNA CTD PMID:26217789 NCBI chr11:124,395,534...124,409,807
Ensembl chr11:124,395,534...124,399,024 		JBrowse link
G OR9K2 olfactory receptor family 9 subfamily K member 2 increases expression ISO Thalidomide results in increased expression of OR9K2 mRNA CTD PMID:26217789 NCBI chr12:55,126,406...55,132,750
Ensembl chr12:55,126,406...55,132,750 		JBrowse link
G OSTF1 osteoclast stimulating factor 1 decreases expression ISO Thalidomide results in decreased expression of OSTF1 mRNA CTD PMID:26217789 NCBI chr 9:75,088,514...75,147,265
Ensembl chr 9:75,088,514...75,147,265 		JBrowse link
G PABIR1 PP2A Aalpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1 decreases expression ISO Thalidomide results in decreased expression of PABIR1 mRNA CTD PMID:26217789 NCBI chr 9:68,780,065...68,785,566
Ensembl chr 9:68,780,065...68,785,566 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions
increases cleavage		 EXP [Curcumin co-treated with Thalidomide] results in increased cleavage of PARP1 protein
Thalidomide analog results in increased cleavage of PARP1 protein		 CTD PMID:15858615 PMID:19372569 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154 		JBrowse link
G PAX3 paired box 3 decreases expression EXP Thalidomide results in decreased expression of PAX3 mRNA CTD PMID:31711903 NCBI chr 2:222,199,887...222,298,998
Ensembl chr 2:222,199,887...222,298,998 		JBrowse link
G PAX6 paired box 6 increases expression EXP Thalidomide results in increased expression of PAX6 mRNA CTD PMID:31711903 NCBI chr11:31,789,026...31,817,961
Ensembl chr11:31,784,779...31,817,961 		JBrowse link
G PDCD10 programmed cell death 10 decreases expression ISO Thalidomide results in decreased expression of PDCD10 mRNA CTD PMID:26217789 NCBI chr 3:167,683,298...167,734,892
Ensembl chr 3:167,683,298...167,734,939 		JBrowse link
G PDLIM3 PDZ and LIM domain 3 decreases expression ISO Thalidomide results in decreased expression of PDLIM3 mRNA CTD PMID:26217789 NCBI chr 4:185,500,660...185,535,507
Ensembl chr 4:185,500,660...185,535,507 		JBrowse link
G PECAM1 platelet and endothelial cell adhesion molecule 1 decreases expression ISO
EXP		 Thalidomide results in decreased expression of PECAM1 protein CTD PMID:18291259 PMID:34520751 NCBI chr17:64,319,415...64,390,860
Ensembl chr17:64,319,415...64,413,776 		JBrowse link
G PFDN6 prefoldin subunit 6 decreases expression ISO Thalidomide results in decreased expression of PFDN6 mRNA CTD PMID:26217789 NCBI chr 6:33,289,197...33,290,934
Ensembl chr 6:33,289,302...33,298,401 		JBrowse link
G PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha multiple interactions EXP [ERBB2 protein co-treated with PIK3CA protein mutant form] results in increased susceptibility to Thalidomide metabolite CTD PMID:28745489 NCBI chr 3:179,148,126...179,240,093
Ensembl chr 3:179,148,114...179,240,093 		JBrowse link
G PILRA paired immunoglobin like type 2 receptor alpha decreases expression ISO Thalidomide results in decreased expression of PILRA mRNA CTD PMID:26217789 NCBI chr 7:100,371,291...100,400,096
Ensembl chr 7:100,367,530...100,400,096 		JBrowse link
G PIM1 Pim-1 proto-oncogene, serine/threonine kinase decreases expression EXP Thalidomide results in decreased expression of PIM1 protein CTD PMID:16616857 NCBI chr 6:37,170,152...37,175,428
Ensembl chr 6:37,170,152...37,175,428 		JBrowse link
G PLAU plasminogen activator, urokinase decreases expression ISO Thalidomide results in decreased expression of PLAU protein CTD PMID:16288038 NCBI chr10:73,909,164...73,917,494
Ensembl chr10:73,909,177...73,917,496 		JBrowse link
G PLAUR plasminogen activator, urokinase receptor multiple interactions
decreases expression		 EXP
ISO		 Thalidomide inhibits the reaction [TGFB1 protein results in increased expression of PLAUR mRNA]; Thalidomide inhibits the reaction [TGFB1 protein results in increased expression of PLAUR protein]
Thalidomide results in decreased expression of PLAUR protein		 CTD PMID:16288038 NCBI chr19:43,646,095...43,670,169
Ensembl chr19:43,646,095...43,670,547 		JBrowse link
G PLTP phospholipid transfer protein decreases expression ISO Thalidomide results in decreased expression of PLTP mRNA CTD PMID:26217789 NCBI chr20:45,898,620...45,912,155
Ensembl chr20:45,898,621...45,912,155 		JBrowse link
G POLR2K RNA polymerase II, I and III subunit K decreases expression ISO Thalidomide results in decreased expression of POLR2K mRNA CTD PMID:26217789 NCBI chr 8:100,150,636...100,154,003
Ensembl chr 8:100,150,623...100,154,003 		JBrowse link
G POPDC2 popeye domain containing 2 decreases expression ISO Thalidomide results in decreased expression of POPDC2 mRNA CTD PMID:26217789 NCBI chr 3:119,642,056...119,660,883
Ensembl chr 3:119,636,457...119,665,324 		JBrowse link
G PPARD peroxisome proliferator activated receptor delta increases response to substance EXP PPARD gene SNP results in increased susceptibility to Thalidomide CTD PMID:21245421 NCBI chr 6:35,342,558...35,428,178
Ensembl chr 6:35,342,558...35,428,191 		JBrowse link
G PPP1R11 protein phosphatase 1 regulatory inhibitor subunit 11 decreases expression ISO Thalidomide results in decreased expression of PPP1R11 mRNA CTD PMID:26217789 NCBI chr 6:30,061,265...30,070,333
Ensembl chr 6:30,066,709...30,070,333 		JBrowse link
G PPP1R15A protein phosphatase 1 regulatory subunit 15A increases expression EXP Thalidomide analog results in increased expression of PPP1R15A mRNA CTD PMID:20525221 NCBI chr19:48,872,421...48,876,058
Ensembl chr19:48,872,212...48,876,059 		JBrowse link
G PPP1R1A protein phosphatase 1 regulatory inhibitor subunit 1A decreases expression ISO Thalidomide results in decreased expression of PPP1R1A mRNA CTD PMID:26217789 NCBI chr12:54,579,246...54,588,659
Ensembl chr12:54,575,387...54,588,659 		JBrowse link
G PRELID2 PRELI domain containing 2 decreases expression ISO Thalidomide results in decreased expression of PRELID2 mRNA CTD PMID:26217789 NCBI chr 5:145,228,985...145,835,342
Ensembl chr 5:145,471,799...145,835,369 		JBrowse link
G PRF1 perforin 1 increases expression ISO Thalidomide results in increased expression of PRF1 CTD PMID:17089043 NCBI chr10:70,597,348...70,602,741
Ensembl chr10:70,597,348...70,602,759 		JBrowse link
G PRKCD protein kinase C delta decreases expression EXP Thalidomide results in decreased expression of PRKCD mRNA CTD PMID:32756504 NCBI chr 3:53,161,209...53,192,717
Ensembl chr 3:53,156,009...53,192,717 		JBrowse link
G PRKG1 protein kinase cGMP-dependent 1 decreases expression ISO Thalidomide results in decreased expression of PRKG1 mRNA CTD PMID:26217789 NCBI chr10:50,990,888...52,298,350
Ensembl chr10:50,990,888...52,298,423 		JBrowse link
G PRR5 proline rich 5 decreases expression ISO Thalidomide results in decreased expression of PRR5 mRNA CTD PMID:26217789 NCBI chr22:44,668,751...44,737,681
Ensembl chr22:44,668,547...44,737,681 		JBrowse link
G PRXL2A peroxiredoxin like 2A decreases expression ISO Thalidomide results in decreased expression of PRXL2A mRNA CTD PMID:26217789 NCBI chr10:80,407,829...80,437,115
Ensembl chr10:80,407,829...80,437,115 		JBrowse link
G PSME2 proteasome activator subunit 2 increases expression ISO Thalidomide results in increased expression of PSME2 mRNA CTD PMID:26217789 NCBI chr14:24,143,365...24,146,610
Ensembl chr14:24,143,362...24,147,570 		JBrowse link
G PTEN phosphatase and tensin homolog increases expression EXP Thalidomide results in increased expression of PTEN protein CTD PMID:19567134 NCBI chr10:87,863,625...87,971,930
Ensembl chr10:87,862,638...87,971,930 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 increases degradation
decreases stability
multiple interactions
decreases expression		 EXP
ISO		 Thalidomide results in increased degradation of PTGS2 protein
Thalidomide results in decreased stability of PTGS2 mRNA
Thalidomide analog inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2]; Thalidomide inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Thalidomide inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
Thalidomide inhibits the reaction [Ifosfamide results in increased expression of PTGS2 protein]
Thalidomide results in decreased expression of PTGS2 protein		 CTD PMID:11705847 PMID:15982930 PMID:17638016 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G RAB2B RAB2B, member RAS oncogene family decreases expression ISO Thalidomide results in decreased expression of RAB2B mRNA CTD PMID:26006729 PMID:26217789 NCBI chr14:21,459,020...21,476,959
Ensembl chr14:21,459,020...21,476,960 		JBrowse link
G RAB8A RAB8A, member RAS oncogene family decreases expression ISO Thalidomide results in decreased expression of RAB8A mRNA CTD PMID:26006729 NCBI chr19:16,111,889...16,134,234
Ensembl chr19:16,111,889...16,134,234 		JBrowse link
G RAP1B RAP1B, member of RAS oncogene family decreases expression ISO Thalidomide results in decreased expression of RAP1B mRNA CTD PMID:26006729 NCBI chr12:68,610,899...68,671,901
Ensembl chr12:68,610,855...68,671,901 		JBrowse link
G RASSF9 Ras association domain family member 9 decreases expression ISO Thalidomide results in decreased expression of RASSF9 mRNA CTD PMID:26217789 NCBI chr12:85,800,703...85,836,409
Ensembl chr12:85,800,703...85,836,409 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions
decreases expression		 EXP
ISO		 [irinotecan co-treated with Thalidomide co-treated with Celecoxib] results in increased expression of RELA protein; [irinotecan co-treated with Thalidomide] results in increased expression of RELA protein; [resveratrol co-treated with Thalidomide] results in decreased activity of [RELA protein binds to NFKB1 protein]; Thalidomide inhibits the reaction [TNF protein results in increased transport of RELA protein]
Thalidomide analog inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]; Thalidomide inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]; Thalidomide inhibits the reaction [Paraquat affects the localization of RELA protein]
Thalidomide results in decreased expression of RELA protein
[Thalidomide co-treated with Dimethylnitrosamine] results in decreased transport of RELA protein; Thalidomide inhibits the reaction [Carbon Tetrachloride results in increased expression of RELA mRNA]; Thalidomide inhibits the reaction [Carbon Tetrachloride results in increased expression of RELA protein]; Thalidomide inhibits the reaction [TNF protein results in increased expression of RELA mRNA]		 CTD PMID:15687330 PMID:16078585 PMID:16333628 PMID:16604421 PMID:16685529 More... NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G RELB RELB proto-oncogene, NF-kB subunit increases expression EXP Thalidomide analog results in increased expression of RELB mRNA CTD PMID:20525221 NCBI chr19:45,001,464...45,038,192
Ensembl chr19:45,001,461...45,038,192 		JBrowse link
G RFC3 replication factor C subunit 3 multiple interactions EXP [Azacitidine co-treated with Thalidomide] affects the expression of RFC3 mRNA CTD PMID:18720364 NCBI chr13:33,818,149...33,977,377
Ensembl chr13:33,818,069...33,966,558 		JBrowse link
G RHOA ras homolog family member A affects expression ISO Thalidomide affects the expression of RHOA mRNA CTD PMID:26006729 NCBI chr 3:49,359,145...49,411,976
Ensembl chr 3:49,359,139...49,412,998 		JBrowse link
G RNASEH2C ribonuclease H2 subunit C decreases expression ISO Thalidomide results in decreased expression of RNASEH2C mRNA CTD PMID:26217789 NCBI chr11:65,717,673...65,720,798
Ensembl chr11:65,714,005...65,720,818 		JBrowse link
G RNF138 ring finger protein 138 decreases expression ISO Thalidomide results in decreased expression of RNF138 mRNA CTD PMID:26217789 NCBI chr18:32,091,874...32,131,561
Ensembl chr18:32,091,874...32,131,561 		JBrowse link
G RNF166 ring finger protein 166 multiple interactions EXP Thalidomide results in increased degradation of and results in decreased expression of RNF166 protein CTD PMID:30067223 NCBI chr16:88,696,501...88,706,408
Ensembl chr16:88,696,499...88,706,408 		JBrowse link
G RPS15 ribosomal protein S15 increases expression ISO Thalidomide results in increased expression of RPS15 mRNA CTD PMID:26217789 NCBI chr19:1,438,396...1,440,495
Ensembl chr19:1,438,358...1,440,495 		JBrowse link
G RPS6KA2 ribosomal protein S6 kinase A2 decreases expression ISO Thalidomide results in decreased expression of RPS6KA2 mRNA CTD PMID:26217789 NCBI chr 6:166,409,364...166,862,773
Ensembl chr 6:166,409,364...166,906,451 		JBrowse link
G RRAS RAS related decreases expression ISO Thalidomide results in decreased expression of RRAS mRNA CTD PMID:26006729 PMID:26217789 NCBI chr19:49,635,292...49,640,143
Ensembl chr19:49,635,292...49,640,143 		JBrowse link
G RRM2 ribonucleotide reductase regulatory subunit M2 multiple interactions EXP [Azacitidine co-treated with Thalidomide] affects the expression of RRM2 mRNA CTD PMID:18720364 NCBI chr 2:10,122,568...10,211,010
Ensembl chr 2:10,120,698...10,211,725 		JBrowse link
G RTN2 reticulon 2 decreases expression ISO Thalidomide results in decreased expression of RTN2 mRNA CTD PMID:26217789 NCBI chr19:45,485,294...45,497,047
Ensembl chr19:45,485,294...45,497,055 		JBrowse link
G RYR2 ryanodine receptor 2 decreases expression ISO Thalidomide results in decreased expression of RYR2 mRNA CTD PMID:26006729 PMID:26217789 NCBI chr 1:237,042,184...237,833,988
Ensembl chr 1:237,042,184...237,833,988 		JBrowse link
G SALL4 spalt like transcription factor 4 affects binding
multiple interactions
increases expression		 EXP Thalidomide binds to [SALL4 protein binds to CRBN protein]
Bortezomib inhibits the reaction [Thalidomide results in increased degradation of and results in decreased expression of SALL4 protein]; pevonedistat inhibits the reaction [Thalidomide results in increased degradation of and results in decreased expression of SALL4 protein]; TAK-243 inhibits the reaction [Thalidomide results in increased degradation of and results in decreased expression of SALL4 protein]; Thalidomide results in increased degradation of and results in decreased expression of SALL4 protein
Thalidomide results in increased expression of SALL4 mRNA		 CTD PMID:30067223 NCBI chr20:51,782,331...51,802,521
Ensembl chr20:51,782,331...51,802,521 		JBrowse link
G SAP30 Sin3A associated protein 30 decreases expression ISO Thalidomide results in decreased expression of SAP30 mRNA CTD PMID:26217789 NCBI chr 4:173,370,954...173,377,532
Ensembl chr 4:173,369,969...173,377,532 		JBrowse link
G SAT1 spermidine/spermine N1-acetyltransferase 1 decreases expression ISO Thalidomide results in decreased expression of SAT1 mRNA CTD PMID:26217789 NCBI chr  X:23,783,173...23,786,210
Ensembl chr  X:23,783,173...23,786,210 		JBrowse link
G SCN7A sodium voltage-gated channel alpha subunit 7 decreases expression ISO Thalidomide results in decreased expression of SCN7A mRNA CTD PMID:26217789 NCBI chr 2:166,403,573...166,494,249
Ensembl chr 2:166,403,573...166,611,482 		JBrowse link
G SDHAF1 succinate dehydrogenase complex assembly factor 1 decreases expression ISO Thalidomide results in decreased expression of SDHAF1 mRNA CTD PMID:26217789 NCBI chr19:35,995,188...35,996,312
Ensembl chr19:35,995,188...35,996,312 		JBrowse link
G SDHC succinate dehydrogenase complex subunit C decreases expression ISO Thalidomide results in decreased expression of SDHC mRNA CTD PMID:26217789 NCBI chr 1:161,314,381...161,363,206
Ensembl chr 1:161,314,381...161,363,206 		JBrowse link
G SELENOS selenoprotein S decreases expression ISO Thalidomide results in decreased expression of SELENOS mRNA CTD PMID:26006729 NCBI chr15:101,270,809...101,277,485
Ensembl chr15:101,270,817...101,277,500 		JBrowse link
G SELL selectin L decreases expression EXP Thalidomide results in decreased expression of SELL protein CTD PMID:16344495 NCBI chr 1:169,690,667...169,711,620
Ensembl chr 1:169,690,665...169,711,702 		JBrowse link
G SERPINB2 serpin family B member 2 increases response to substance EXP SERPINB2 gene SNP results in increased susceptibility to Thalidomide CTD PMID:21245421 NCBI chr18:63,887,705...63,903,888
Ensembl chr18:63,871,692...63,903,888 		JBrowse link
G SFRP2 secreted frizzled related protein 2 increases expression ISO Thalidomide results in increased expression of SFRP2 mRNA CTD PMID:26217789 NCBI chr 4:153,780,591...153,789,083
Ensembl chr 4:153,780,591...153,789,083 		JBrowse link
G SH3BGR SH3 domain binding glutamate rich protein decreases expression ISO Thalidomide results in decreased expression of SH3BGR mRNA CTD PMID:26217789 NCBI chr21:39,445,865...39,515,506
Ensembl chr21:39,445,855...39,515,506 		JBrowse link
G SLC12A6 solute carrier family 12 member 6 increases response to substance EXP SLC12A6 gene SNP results in increased susceptibility to Thalidomide CTD PMID:21245421 NCBI chr15:34,229,784...34,338,057
Ensembl chr15:34,229,784...34,338,060 		JBrowse link
G SLC13A4 solute carrier family 13 member 4 decreases expression ISO Thalidomide results in decreased expression of SLC13A4 mRNA CTD PMID:26217789 NCBI chr 7:135,681,231...135,728,186
Ensembl chr 7:135,681,231...135,729,258 		JBrowse link
G SLC22A2 solute carrier family 22 member 2 multiple interactions EXP Thalidomide inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638 		JBrowse link
G SLC25A20 solute carrier family 25 member 20 decreases expression ISO Thalidomide results in decreased expression of SLC25A20 mRNA CTD PMID:26217789 NCBI chr 3:48,856,926...48,898,882
Ensembl chr 3:48,856,926...48,898,904 		JBrowse link
G SLC25A30 solute carrier family 25 member 30 decreases expression ISO Thalidomide results in decreased expression of SLC25A30 mRNA CTD PMID:26217789 NCBI chr13:45,393,316...45,434,016
Ensembl chr13:45,393,316...45,418,455 		JBrowse link
G SLC2A3 solute carrier family 2 member 3 increases expression ISO Thalidomide results in increased expression of SLC2A3 mRNA CTD PMID:26217789 NCBI chr12:7,919,230...7,936,187
Ensembl chr12:7,919,230...8,019,007 		JBrowse link
G SLC44A3 solute carrier family 44 member 3 decreases expression ISO Thalidomide results in decreased expression of SLC44A3 mRNA CTD PMID:26217789 NCBI chr 1:94,820,357...94,895,247
Ensembl chr 1:94,820,342...94,895,246 		JBrowse link
G SLC8A1 solute carrier family 8 member A1 decreases expression ISO Thalidomide results in decreased expression of SLC8A1 mRNA CTD PMID:26006729 PMID:26217789 NCBI chr 2:40,097,270...40,512,435
Ensembl chr 2:40,097,270...40,611,053 		JBrowse link
G SLCO4C1 solute carrier organic anion transporter family member 4C1 decreases expression ISO Thalidomide results in decreased expression of SLCO4C1 mRNA CTD PMID:26217789 NCBI chr 5:102,233,986...102,296,284
Ensembl chr 5:102,233,986...102,296,284 		JBrowse link
G SMPD2 sphingomyelin phosphodiesterase 2 multiple interactions EXP sphingosine 1-phosphate inhibits the reaction [Thalidomide results in increased activity of SMPD2 protein] CTD PMID:15741222 NCBI chr 6:109,440,724...109,443,919
Ensembl chr 6:109,440,724...109,443,919 		JBrowse link
G SMYD1 SET and MYND domain containing 1 decreases expression ISO Thalidomide results in decreased expression of SMYD1 mRNA CTD PMID:26006729 PMID:26217789 NCBI chr 2:88,067,825...88,113,384
Ensembl chr 2:88,067,825...88,113,384 		JBrowse link
G SNAP25 synaptosome associated protein 25 increases expression ISO Thalidomide results in increased expression of SNAP25 mRNA; Thalidomide results in increased expression of SNAP25 protein CTD PMID:27693314 NCBI chr20:10,218,830...10,307,418
Ensembl chr20:10,172,395...10,308,258 		JBrowse link
G SNORD104 small nucleolar RNA, C/D box 104 increases expression ISO Thalidomide results in increased expression of SNORD104 mRNA CTD PMID:26217789 NCBI chr17:64,146,078...64,146,157
Ensembl chr17:64,146,083...64,146,152 		JBrowse link
G SNORD111 small nucleolar RNA, C/D box 111 increases expression ISO Thalidomide results in increased expression of SNORD111 mRNA CTD PMID:26217789 NCBI chr16:70,538,005...70,538,098
Ensembl chr16:70,538,005...70,538,098 		JBrowse link
G SNORD123 small nucleolar RNA, C/D box 123 increases expression ISO Thalidomide results in increased expression of SNORD123 mRNA CTD PMID:26217789 NCBI chr 5:9,548,827...9,548,914
Ensembl chr 5:9,548,836...9,548,905 		JBrowse link
G SNRPD1 small nuclear ribonucleoprotein D1 polypeptide decreases expression ISO Thalidomide results in decreased expression of SNRPD1 mRNA CTD PMID:26217789 NCBI chr18:21,612,314...21,633,520
Ensembl chr18:21,612,314...21,633,524 		JBrowse link
G SNX16 sorting nexin 16 increases expression EXP Thalidomide analog results in increased expression of SNX16 mRNA CTD PMID:20525221 NCBI chr 8:81,799,583...81,842,185
Ensembl chr 8:81,799,581...81,842,866 		JBrowse link
G SNX24 sorting nexin 24 decreases expression ISO Thalidomide results in decreased expression of SNX24 mRNA CTD PMID:26217789 NCBI chr 5:122,845,613...123,029,318
Ensembl chr 5:122,843,439...123,029,354 		JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions ISO Thalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of FASL mRNA]; Thalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of IL12B mRNA]; Thalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of TNF mRNA]; Thalidomide promotes the reaction [SOD1 gene mutant form results in increased expression of IL1RN mRNA]; Thalidomide promotes the reaction [SOD1 gene mutant form results in increased expression of TGFB1 mRNA]
Thalidomide inhibits the reaction [Carbon Tetrachloride results in decreased activity of SOD1 protein]		 CTD PMID:16510725 PMID:17030452 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931 		JBrowse link
G SOX1 SRY-box transcription factor 1 decreases expression ISO Thalidomide results in decreased expression of SOX1 mRNA CTD PMID:26217789 NCBI chr13:112,067,149...112,071,706
Ensembl chr13:112,067,149...112,071,706 		JBrowse link
G SOX17 SRY-box transcription factor 17 decreases localization EXP Thalidomide results in decreased localization of SOX17 protein CTD PMID:24154490 NCBI chr 8:54,457,935...54,460,892
Ensembl chr 8:54,457,935...54,460,892 		JBrowse link
G SP1 Sp1 transcription factor decreases activity EXP Thalidomide results in decreased activity of SP1 protein CTD PMID:10533722 NCBI chr12:53,380,176...53,416,446
Ensembl chr12:53,380,176...53,416,446 		JBrowse link
G SP5 Sp5 transcription factor decreases expression ISO Thalidomide results in decreased expression of SP5 mRNA CTD PMID:26217789 NCBI chr 2:170,715,337...170,718,078
Ensembl chr 2:170,715,337...170,718,078 		JBrowse link
G SPA17 sperm autoantigenic protein 17 decreases expression ISO Thalidomide results in decreased expression of SPA17 mRNA CTD PMID:26217789 NCBI chr11:124,673,904...124,697,518
Ensembl chr11:124,673,844...124,697,518 		JBrowse link
G SPAG5 sperm associated antigen 5 multiple interactions EXP [Azacitidine co-treated with Thalidomide] affects the expression of SPAG5 mRNA CTD PMID:18720364 NCBI chr17:28,577,574...28,599,025
Ensembl chr17:28,577,565...28,599,025 		JBrowse link
G SPHKAP SPHK1 interactor, AKAP domain containing decreases expression ISO Thalidomide results in decreased expression of SPHKAP mRNA CTD PMID:26217789 NCBI chr 2:227,979,955...228,181,687
Ensembl chr 2:227,979,955...228,181,687 		JBrowse link
G SRRD SRR1 domain containing decreases expression ISO Thalidomide results in decreased expression of SRRD mRNA CTD PMID:26217789 NCBI chr22:26,483,877...26,494,658
Ensembl chr22:26,483,877...26,494,658 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 decreases phosphorylation
multiple interactions		 EXP Thalidomide analog results in decreased phosphorylation of STAT3 protein
[Resveratrol co-treated with Thalidomide] results in decreased phosphorylation of STAT3 protein; Thalidomide promotes the reaction [Capsaicin results in decreased phosphorylation of and results in decreased activity of STAT3 protein]		 CTD PMID:15858615 PMID:17164350 PMID:17505005 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568 		JBrowse link
G STMN2 stathmin 2 decreases expression ISO Thalidomide results in decreased expression of STMN2 mRNA CTD PMID:26217789 NCBI chr 8:79,611,117...79,666,158
Ensembl chr 8:79,611,117...79,666,158 		JBrowse link
G SWSAP1 SWIM-type zinc finger 7 associated protein 1 decreases expression ISO Thalidomide results in decreased expression of SWSAP1 mRNA CTD PMID:26217789 NCBI chr19:11,374,666...11,376,169
Ensembl chr19:11,374,666...11,376,951 		JBrowse link
G SYNJ2BP synaptojanin 2 binding protein decreases expression ISO Thalidomide results in decreased expression of SYNJ2BP mRNA CTD PMID:26006729 NCBI chr14:70,366,499...70,417,090
Ensembl chr14:70,366,499...70,417,090 		JBrowse link
G SYT15 synaptotagmin 15 decreases expression EXP Thalidomide results in decreased expression of SYT15 mRNA CTD PMID:32756504 NCBI chr10:46,579,128...46,597,108
Ensembl chr10:46,578,217...46,594,173 		JBrowse link
G SYT4 synaptotagmin 4 increases expression EXP Thalidomide results in increased expression of SYT4 mRNA CTD PMID:32756504 NCBI chr18:43,267,892...43,277,490
Ensembl chr18:43,267,892...43,277,535 		JBrowse link
G TC2N tandem C2 domains, nuclear decreases expression ISO Thalidomide results in decreased expression of TC2N mRNA CTD PMID:26217789 NCBI chr14:91,779,746...91,867,536
Ensembl chr14:91,779,746...91,867,536 		JBrowse link
G TCF15 transcription factor 15 decreases expression EXP Thalidomide results in decreased expression of TCF15 mRNA CTD PMID:31711903 NCBI chr20:604,257...610,309
Ensembl chr20:604,257...610,309 		JBrowse link
G TDG thymine DNA glycosylase decreases expression ISO Thalidomide results in decreased expression of TDG mRNA CTD PMID:26217789 NCBI chr12:103,965,872...103,988,874
Ensembl chr12:103,965,822...103,988,874 		JBrowse link
G TEFM transcription elongation factor, mitochondrial decreases expression ISO Thalidomide results in decreased expression of TEFM mRNA CTD PMID:26217789 NCBI chr17:30,898,986...30,906,238
Ensembl chr17:30,897,336...30,906,238 		JBrowse link
G TEK TEK receptor tyrosine kinase decreases expression EXP Thalidomide results in decreased expression of TEK mRNA CTD PMID:15618473 NCBI chr 9:27,109,141...27,230,178
Ensembl chr 9:27,109,141...27,230,174 		JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions
decreases expression		 EXP
ISO		 Thalidomide inhibits the reaction [TGFB1 protein results in increased degradation of NFKBIA protein]; Thalidomide inhibits the reaction [TGFB1 protein results in increased expression of PLAUR mRNA]; Thalidomide inhibits the reaction [TGFB1 protein results in increased expression of PLAUR protein]; Thalidomide inhibits the reaction [TGFB1 protein results in increased phosphorylation of NFKBIA protein]; Thalidomide inhibits the reaction [TGFB1 protein results in increased transport of NFKBIA protein]
Thalidomide results in decreased expression of TGFB1 mRNA
Thalidomide results in decreased expression of TGFB1 mRNA; Thalidomide results in decreased expression of TGFB1 protein
Thalidomide inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]; Thalidomide inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; Thalidomide inhibits the reaction [Dimethylnitrosamine results in increased expression of TGFB1 mRNA]; Thalidomide inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA]; Thalidomide inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; Thalidomide inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]
Thalidomide promotes the reaction [SOD1 gene mutant form results in increased expression of TGFB1 mRNA]		 CTD PMID:15464241 PMID:16288038 PMID:16510725 PMID:16549389 PMID:16604421 More... NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G TGFBI transforming growth factor beta induced decreases expression ISO Thalidomide results in decreased expression of TGFBI mRNA CTD PMID:26006729 PMID:26217789 NCBI chr 5:136,028,988...136,063,818
Ensembl chr 5:136,028,988...136,063,818 		JBrowse link
G TGFBR1 transforming growth factor beta receptor 1 decreases expression EXP Thalidomide results in decreased expression of TGFBR1 mRNA; Thalidomide results in decreased expression of TGFBR1 protein CTD PMID:15618473 NCBI chr 9:99,103,647...99,154,192
Ensembl chr 9:99,104,038...99,154,192 		JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO Thalidomide inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 mRNA]; Thalidomide inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 protein]; Thalidomide inhibits the reaction [Thioacetamide results in increased expression of TIMP1 mRNA] CTD PMID:15464241 PMID:17030452 NCBI chr  X:47,582,436...47,586,789
Ensembl chr  X:47,582,408...47,586,789 		JBrowse link
G TIMP2 TIMP metallopeptidase inhibitor 2 multiple interactions ISO Thalidomide inhibits the reaction [Thioacetamide results in increased expression of TIMP2 mRNA] CTD PMID:15464241 NCBI chr17:78,852,977...78,925,387
Ensembl chr17:78,852,977...78,925,387 		JBrowse link
G TINAGL1 tubulointerstitial nephritis antigen like 1 decreases expression ISO Thalidomide results in decreased expression of TINAGL1 mRNA CTD PMID:26217789 NCBI chr 1:31,576,515...31,587,686
Ensembl chr 1:31,576,485...31,587,686 		JBrowse link
G TJP1 tight junction protein 1 multiple interactions ISO Thalidomide inhibits the reaction [dinitrobenzenesulfonic acid results in decreased expression of TJP1 protein] CTD PMID:16680017 NCBI chr15:29,699,367...29,969,049
Ensembl chr15:29,699,367...29,968,915 		JBrowse link
G TM2D3 TM2 domain containing 3 decreases expression ISO Thalidomide results in decreased expression of TM2D3 mRNA CTD PMID:26217789 NCBI chr15:101,632,977...101,652,381
Ensembl chr15:101,621,444...101,652,391 		JBrowse link
G TMEM138 transmembrane protein 138 decreases expression ISO Thalidomide results in decreased expression of TMEM138 mRNA CTD PMID:26217789 NCBI chr11:61,362,374...61,376,870
Ensembl chr11:61,361,964...61,377,890 		JBrowse link
G TMEM176A transmembrane protein 176A decreases expression ISO Thalidomide results in decreased expression of TMEM176A mRNA CTD PMID:26217789 NCBI chr 7:150,800,769...150,805,118
Ensembl chr 7:150,800,403...150,805,118 		JBrowse link
G TMPO thymopoietin multiple interactions EXP [Azacitidine co-treated with Thalidomide] affects the expression of TMPO mRNA CTD PMID:18720364 NCBI chr12:98,515,573...98,550,351
Ensembl chr12:98,515,579...98,550,351 		JBrowse link
G TNF tumor necrosis factor multiple interactions
decreases expression
increases degradation
increases expression		 EXP
ISO		 Thalidomide analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Endotoxins results in increased expression of TNF protein]; Thalidomide inhibits the reaction [lipophosphonoglycan results in increased secretion of TNF protein]; Thalidomide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Thalidomide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Thalidomide inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; Thalidomide inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; Thalidomide inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Thalidomide inhibits the reaction [TNF protein results in increased transport of RELA protein]
Thalidomide results in decreased expression of TNF protein
Thalidomide results in decreased expression of TNF mRNA; Thalidomide results in decreased expression of TNF protein
Thalidomide results in increased degradation of TNF mRNA
Thalidomide results in increased expression of TNF mRNA
Thalidomide inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Dimethylnitrosamine results in increased expression of TNF mRNA]; Thalidomide inhibits the reaction [irinotecan results in increased expression of TNF mRNA]; Thalidomide inhibits the reaction [irinotecan results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; Thalidomide inhibits the reaction [Paraquat results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Thioacetamide results in increased expression of TNF mRNA]; Thalidomide inhibits the reaction [TNF protein results in increased expression of CHUK protein]; Thalidomide inhibits the reaction [TNF protein results in increased expression of COL1A2 mRNA]; Thalidomide inhibits the reaction [TNF protein results in increased expression of RELA mRNA]; Thalidomide inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; Thalidomide inhibits the reaction [Zymosan results in increased expression of TNF protein]
Thalidomide results in increased expression of TNF protein
Thalidomide analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Thalidomide inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased expression of TNF protein]; Thalidomide inhibits the reaction [dinitrobenzenesulfonic acid results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Thalidomide inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; Thalidomide inhibits the reaction [SOD1 gene mutant form results in increased expression of TNF mRNA]; Thalidomide inhibits the reaction [Zymosan results in increased expression of TNF mRNA]; TNF protein affects the reaction [vadimezan affects the metabolism of Thalidomide]		 CTD PMID:9068814 PMID:9623511 PMID:10496904 PMID:10720640 PMID:11367517 More... NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TNFRSF10A TNF receptor superfamily member 10a decreases expression EXP Thalidomide results in decreased expression of TNFRSF10A protein CTD PMID:16531263 NCBI chr 8:23,190,452...23,225,102
Ensembl chr 8:23,190,452...23,225,102 		JBrowse link
G TNFRSF10B TNF receptor superfamily member 10b decreases expression EXP Thalidomide results in decreased expression of TNFRSF10B protein CTD PMID:16531263 NCBI chr 8:23,020,133...23,069,031
Ensembl chr 8:23,020,133...23,069,031 		JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A decreases expression EXP Thalidomide results in decreased expression of TNFRSF1A mRNA; Thalidomide results in decreased expression of TNFRSF1A protein CTD PMID:15618473 PMID:16344495 NCBI chr12:6,328,771...6,342,076
Ensembl chr12:6,328,757...6,342,114 		JBrowse link
G TNFRSF1B TNF receptor superfamily member 1B decreases expression EXP Thalidomide results in decreased expression of TNFRSF1B mRNA CTD PMID:15618473 NCBI chr 1:12,166,991...12,209,220
Ensembl chr 1:12,166,991...12,209,228 		JBrowse link
G TNFSF10 TNF superfamily member 10 decreases expression EXP Thalidomide results in decreased expression of TNFSF10 protein CTD PMID:16531263 NCBI chr 3:172,505,508...172,523,430
Ensembl chr 3:172,505,508...172,523,475 		JBrowse link
G TNFSF11 TNF superfamily member 11 multiple interactions EXP [Thalidomide co-treated with Dexamethasone] results in decreased expression of TNFSF11 protein CTD PMID:16079895 NCBI chr13:42,562,736...42,608,013
Ensembl chr13:42,562,736...42,608,013 		JBrowse link
G TNNC1 troponin C1, slow skeletal and cardiac type decreases expression ISO Thalidomide results in decreased expression of TNNC1 mRNA CTD PMID:26006729 PMID:26217789 NCBI chr 3:52,451,100...52,454,041
Ensembl chr 3:52,451,100...52,454,041 		JBrowse link
G TOP2A DNA topoisomerase II alpha multiple interactions EXP [Azacitidine co-treated with Thalidomide] affects the expression of TOP2A mRNA CTD PMID:18720364 NCBI chr17:40,388,525...40,417,896
Ensembl chr17:40,388,525...40,417,896 		JBrowse link
G TP53 tumor protein p53 increases expression EXP Thalidomide analog results in increased expression of TP53 mRNA CTD PMID:20525221 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546 		JBrowse link
G TRAM1L1 translocation associated membrane protein 1 like 1 decreases expression ISO Thalidomide results in decreased expression of TRAM1L1 mRNA CTD PMID:26217789 NCBI chr 4:117,083,554...117,085,576
Ensembl chr 4:117,083,554...117,085,576 		JBrowse link
G TRAPPC2L trafficking protein particle complex subunit 2L decreases expression ISO Thalidomide results in decreased expression of TRAPPC2L mRNA CTD PMID:26217789 NCBI chr16:88,856,220...88,862,678
Ensembl chr16:88,856,220...88,862,686 		JBrowse link
G TRIB3 tribbles pseudokinase 3 increases expression EXP Thalidomide analog results in increased expression of TRIB3 mRNA CTD PMID:20525221 NCBI chr20:380,760...397,559
Ensembl chr20:362,835...397,559 		JBrowse link
G TRIM55 tripartite motif containing 55 decreases expression ISO Thalidomide results in decreased expression of TRIM55 mRNA CTD PMID:26217789 NCBI chr 8:66,113,351...66,175,485
Ensembl chr 8:66,126,896...66,175,485 		JBrowse link
G TSPAN33 tetraspanin 33 decreases expression ISO Thalidomide results in decreased expression of TSPAN33 mRNA CTD PMID:26217789 NCBI chr 7:129,144,707...129,169,699
Ensembl chr 7:129,144,707...129,169,699 		JBrowse link
G TTC32 tetratricopeptide repeat domain 32 decreases expression ISO Thalidomide results in decreased expression of TTC32 mRNA CTD PMID:26217789 NCBI chr 2:19,896,631...19,901,983
Ensembl chr 2:19,896,631...19,901,983 		JBrowse link
G TTK TTK protein kinase multiple interactions EXP [Azacitidine co-treated with Thalidomide] affects the expression of TTK mRNA CTD PMID:18720364 NCBI chr 6:80,004,649...80,042,527
Ensembl chr 6:80,003,887...80,042,527 		JBrowse link
G TTN titin decreases expression ISO Thalidomide results in decreased expression of TTN mRNA CTD PMID:26006729 PMID:26217789 NCBI chr 2:178,525,989...178,807,423
Ensembl chr 2:178,525,989...178,830,802 		JBrowse link
G UBE2C ubiquitin conjugating enzyme E2 C multiple interactions EXP [Azacitidine co-treated with Thalidomide] affects the expression of UBE2C mRNA CTD PMID:18720364 NCBI chr20:45,812,644...45,816,952
Ensembl chr20:45,812,576...45,816,957 		JBrowse link
G UBXN1 UBX domain protein 1 decreases expression ISO Thalidomide results in decreased expression of UBXN1 mRNA CTD PMID:26217789 NCBI chr11:62,676,500...62,679,073
Ensembl chr11:62,676,498...62,679,117 		JBrowse link
G UCHL3 ubiquitin C-terminal hydrolase L3 decreases expression ISO Thalidomide results in decreased expression of UCHL3 mRNA CTD PMID:26217789 NCBI chr13:75,549,502...75,606,020
Ensembl chr13:75,549,483...75,606,020 		JBrowse link
G UNCX UNC homeobox decreases expression EXP Thalidomide results in decreased expression of UNCX mRNA CTD PMID:31711903 NCBI chr 7:1,232,872...1,237,326
Ensembl chr 7:1,232,872...1,237,326 		JBrowse link
G UPP1 uridine phosphorylase 1 decreases expression ISO Thalidomide results in decreased expression of UPP1 mRNA CTD PMID:26217789 NCBI chr 7:48,088,704...48,108,736
Ensembl chr 7:48,088,628...48,108,736 		JBrowse link
G UQCC5 ubiquinol-cytochrome c reductase complex assembly factor 5 decreases expression ISO Thalidomide results in decreased expression of UQCC5 mRNA CTD PMID:26217789 NCBI chr 3:52,536,605...52,541,890
Ensembl chr 3:52,534,013...52,579,237 		JBrowse link
G VCAM1 vascular cell adhesion molecule 1 decreases expression ISO Thalidomide results in decreased expression of VCAM1 mRNA; Thalidomide results in decreased expression of VCAM1 protein CTD PMID:17174718 NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045 		JBrowse link
G VEGFA vascular endothelial growth factor A affects expression
multiple interactions
decreases expression
increases expression
decreases activity
decreases secretion
affects secretion		 EXP
ISO		 Thalidomide affects the expression of VEGFA mRNA; Thalidomide affects the expression of VEGFA protein
[Arsenic Trioxide co-treated with Thalidomide] results in decreased expression of VEGFA mRNA; FGD5-AS1 inhibits the reaction [Thalidomide results in decreased expression of and results in decreased secretion of VEGFA protein]; Thalidomide results in decreased expression of and results in decreased secretion of VEGFA protein
[temozolomide co-treated with Thalidomide] results in decreased expression of VEGFA protein
Thalidomide results in decreased expression of VEGFA protein
Thalidomide results in decreased expression of VEGFA mRNA
[Thalidomide co-treated with Paclitaxel] results in decreased expression of VEGFA mRNA
Thalidomide results in increased expression of VEGFA protein
Thalidomide results in decreased expression of VEGFA mRNA; Thalidomide results in decreased expression of VEGFA protein
Thalidomide results in decreased activity of VEGFA protein
Thalidomide analog results in decreased secretion of VEGFA protein
Thalidomide affects the secretion of VEGFA protein		 CTD PMID:15858615 PMID:15863203 PMID:15939924 PMID:15982930 PMID:16313753 More... NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
G VEGFB vascular endothelial growth factor B multiple interactions
decreases expression		 EXP [Arsenic Trioxide co-treated with Thalidomide] results in decreased expression of VEGFB mRNA
Thalidomide results in decreased expression of VEGFB mRNA		 CTD PMID:29699374 NCBI chr11:64,234,584...64,239,264
Ensembl chr11:64,234,584...64,239,264 		JBrowse link
G VEGFC vascular endothelial growth factor C affects expression EXP Thalidomide affects the expression of VEGFC mRNA CTD PMID:29699374 NCBI chr 4:176,683,538...176,792,922
Ensembl chr 4:176,683,538...176,792,922 		JBrowse link
G VEGFD vascular endothelial growth factor D decreases expression
multiple interactions		 EXP Thalidomide results in decreased expression of VEGFD mRNA
[Arsenic Trioxide co-treated with Thalidomide] results in decreased expression of VEGFD mRNA		 CTD PMID:29699374 NCBI chr  X:15,345,596...15,384,413
Ensembl chr  X:15,345,596...15,384,413 		JBrowse link
G VTN vitronectin decreases expression ISO Thalidomide results in decreased expression of VTN mRNA CTD PMID:26217789 NCBI chr17:28,367,284...28,370,307
Ensembl chr17:28,367,284...28,373,091 		JBrowse link
G WNT5B Wnt family member 5B decreases expression EXP Thalidomide results in decreased expression of WNT5B mRNA CTD PMID:24154490 NCBI chr12:1,617,056...1,647,212
Ensembl chr12:1,529,891...1,647,212 		JBrowse link
G WNT8A Wnt family member 8A decreases expression ISO Thalidomide results in decreased expression of WNT8A mRNA CTD PMID:26217789 NCBI chr 5:138,077,367...138,092,365
Ensembl chr 5:138,083,990...138,092,365 		JBrowse link
G XIAP X-linked inhibitor of apoptosis decreases expression EXP Thalidomide analog results in decreased expression of XIAP protein CTD PMID:15858615 NCBI chr  X:123,859,708...123,913,972
Ensembl chr  X:123,859,712...123,913,972 		JBrowse link
G YJU2B YJU2 splicing factor homolog B decreases expression ISO Thalidomide results in decreased expression of YJU2B mRNA CTD PMID:26217789 NCBI chr19:13,731,752...13,763,289
Ensembl chr19:13,731,760...13,763,296 		JBrowse link
G ZCCHC17 zinc finger CCHC-type containing 17 increases expression ISO Thalidomide results in increased expression of ZCCHC17 mRNA CTD PMID:26217789 NCBI chr 1:31,297,032...31,364,936
Ensembl chr 1:31,296,982...31,364,953 		JBrowse link
G ZEB1 zinc finger E-box binding homeobox 1 multiple interactions
decreases expression		 EXP FGD5-AS1 inhibits the reaction [Thalidomide results in decreased expression of ZEB1 protein] CTD PMID:34520751 NCBI chr10:31,318,417...31,529,804
Ensembl chr10:31,318,495...31,529,814 		JBrowse link
G ZFPL1 zinc finger protein like 1 decreases expression ISO Thalidomide results in decreased expression of ZFPL1 mRNA CTD PMID:26217789 NCBI chr11:65,084,222...65,088,398
Ensembl chr11:65,084,210...65,088,398 		JBrowse link
G ZKSCAN5 zinc finger with KRAB and SCAN domains 5 decreases expression ISO Thalidomide results in decreased expression of ZKSCAN5 mRNA CTD PMID:26217789 NCBI chr 7:99,504,662...99,534,700
Ensembl chr 7:99,504,662...99,534,700 		JBrowse link
G ZMAT5 zinc finger matrin-type 5 decreases expression ISO Thalidomide results in decreased expression of ZMAT5 mRNA CTD PMID:26217789 NCBI chr22:29,730,956...29,767,007
Ensembl chr22:29,730,956...29,767,011 		JBrowse link
G ZNF506 zinc finger protein 506 decreases expression ISO Thalidomide results in decreased expression of ZFP953 mRNA CTD PMID:26217789 NCBI chr19:19,792,711...19,821,750
Ensembl chr19:19,785,839...19,821,751 		JBrowse link
G ZNF692 zinc finger protein 692 multiple interactions EXP Thalidomide results in increased degradation of and results in decreased expression of ZNF692 protein CTD PMID:30067223 NCBI chr 1:248,850,008...248,859,085
Ensembl chr 1:248,850,006...248,859,144 		JBrowse link
G ZNF780B zinc finger protein 780B decreases expression ISO Thalidomide results in decreased expression of ZFP780B mRNA CTD PMID:26217789 NCBI chr19:40,028,260...40,056,231
Ensembl chr19:40,028,260...40,056,231 		JBrowse link
G ZNRD2 zinc ribbon domain containing 2 decreases expression ISO Thalidomide results in decreased expression of ZNRD2 mRNA CTD PMID:26217789 NCBI chr11:65,570,477...65,571,888
Ensembl chr11:65,570,460...65,573,942 		JBrowse link
G ZSCAN12 zinc finger and SCAN domain containing 12 decreases expression ISO Thalidomide results in decreased expression of ZSCAN12 mRNA CTD PMID:26217789 NCBI chr 6:28,378,821...28,399,747
Ensembl chr 6:28,378,955...28,399,747 		JBrowse link
pomalidomide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BRD4 bromodomain containing 4 multiple interactions EXP pomalidomide inhibits the reaction [ARV-825 results in increased degradation of BRD4 protein] CTD PMID:26051217 NCBI chr19:15,235,519...15,332,539
Ensembl chr19:15,235,519...15,332,545 		JBrowse link
G CASP3 caspase 3 multiple interactions EXP [afuresertib co-treated with pomalidomide co-treated with Dexamethasone] results in increased cleavage of CASP3 protein CTD PMID:29928335 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP8 caspase 8 multiple interactions EXP [afuresertib co-treated with pomalidomide co-treated with Dexamethasone] results in increased cleavage of CASP8 protein CTD PMID:29928335 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 increases secretion EXP pomalidomide results in increased secretion of CCL2 protein CTD PMID:15292067 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CEBPA CCAAT enhancer binding protein alpha increases expression EXP pomalidomide results in increased expression of CEBPA mRNA CTD PMID:15292067 NCBI chr19:33,299,934...33,302,534
Ensembl chr19:33,299,934...33,302,534 		JBrowse link
G CEBPD CCAAT enhancer binding protein delta increases expression EXP pomalidomide results in increased expression of CEBPD mRNA CTD PMID:15292067 NCBI chr 8:47,736,913...47,738,164
Ensembl chr 8:47,736,913...47,738,164 		JBrowse link
G CEBPE CCAAT enhancer binding protein epsilon increases expression EXP pomalidomide results in increased expression of CEBPE mRNA CTD PMID:15292067 NCBI chr14:23,117,306...23,119,255
Ensembl chr14:23,117,036...23,120,256 		JBrowse link
G CRBN cereblon multiple interactions
affects binding
increases response to substance		 EXP [pomalidomide co-treated with Dexamethasone co-treated with afuresertib] results in increased expression of CRBN protein; [pomalidomide co-treated with Dexamethasone] results in increased expression of CRBN protein; pomalidomide inhibits the reaction [CRBN protein binds to and results in increased ubiquitination of and results in increased degradation of MEIS2 protein]
pomalidomide binds to [SALL4 protein binds to CRBN protein]
CRBN results in increased susceptibility to pomalidomide		 CTD PMID:25043012 PMID:26186254 PMID:29928335 PMID:30067223 NCBI chr 3:3,149,633...3,179,717
Ensembl chr 3:3,144,628...3,179,727 		JBrowse link
G CSF2 colony stimulating factor 2 decreases secretion EXP pomalidomide results in decreased secretion of CSF2 protein CTD PMID:15292067 NCBI chr 5:132,073,789...132,076,170
Ensembl chr 5:132,073,789...132,076,170 		JBrowse link
G CSF3 colony stimulating factor 3 increases secretion EXP pomalidomide results in increased secretion of CSF3 protein CTD PMID:15292067 NCBI chr17:40,015,440...40,017,813
Ensembl chr17:40,015,361...40,017,813 		JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 increases oxidation EXP CYP2C19 protein results in increased oxidation of pomalidomide CTD PMID:24350712 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547 		JBrowse link
G CYP2J2 cytochrome P450 family 2 subfamily J member 2 increases oxidation EXP CYP2J2 protein results in increased oxidation of pomalidomide CTD PMID:24350712 NCBI chr 1:59,893,308...59,969,212
Ensembl chr 1:59,893,308...59,926,773 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 increases oxidation EXP CYP3A4 protein results in increased oxidation of pomalidomide CTD PMID:24350712 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G DTWD1 DTW domain containing 1 multiple interactions EXP pomalidomide results in increased degradation of and results in decreased expression of DTWD1 protein CTD PMID:30067223 NCBI chr15:49,621,048...49,656,232
Ensembl chr15:49,621,037...49,656,232 		JBrowse link
G EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions EXP [pomalidomide co-treated with Dexamethasone] results in decreased phosphorylation of EIF4EBP1 protein; afuresertib promotes the reaction [[pomalidomide co-treated with Dexamethasone] results in decreased phosphorylation of EIF4EBP1 protein] CTD PMID:29928335 NCBI chr 8:38,030,534...38,060,365
Ensembl chr 8:38,030,534...38,060,365 		JBrowse link
G FAM83F family with sequence similarity 83 member F multiple interactions EXP pomalidomide results in increased degradation of and results in decreased expression of FAM83F protein CTD PMID:30067223 NCBI chr22:39,994,954...40,043,534
Ensembl chr22:39,994,954...40,043,534 		JBrowse link
G FGFR1 fibroblast growth factor receptor 1 decreases expression EXP pomalidomide results in decreased expression of FGFR1 mRNA CTD PMID:30834740 NCBI chr 8:38,411,143...38,468,635
Ensembl chr 8:38,400,215...38,468,834 		JBrowse link
G FGFR3 fibroblast growth factor receptor 3 affects expression EXP pomalidomide affects the expression of FGFR3 mRNA CTD PMID:30834740 NCBI chr 4:1,793,293...1,808,867
Ensembl chr 4:1,793,293...1,808,872 		JBrowse link
G FOXO1 forkhead box O1 multiple interactions EXP [pomalidomide co-treated with Dexamethasone] affects the phosphorylation of FOXO1 protein; afuresertib affects the reaction [[pomalidomide co-treated with Dexamethasone] affects the phosphorylation of FOXO1 protein] CTD PMID:29928335 NCBI chr13:40,555,667...40,666,641
Ensembl chr13:40,555,667...40,666,641 		JBrowse link
G GATA1 GATA binding protein 1 decreases expression EXP pomalidomide results in decreased expression of GATA1 mRNA; pomalidomide results in decreased expression of GATA1 protein CTD PMID:15292067 NCBI chr  X:48,786,590...48,794,311
Ensembl chr  X:48,786,540...48,794,311 		JBrowse link
G GATA2 GATA binding protein 2 decreases expression EXP pomalidomide results in decreased expression of GATA2 mRNA CTD PMID:15292067 NCBI chr 3:128,479,422...128,493,201
Ensembl chr 3:128,479,427...128,493,201 		JBrowse link
G GFI1 growth factor independent 1 transcriptional repressor increases expression EXP pomalidomide results in increased expression of GFI1 mRNA CTD PMID:15292067 NCBI chr 1:92,473,043...92,486,925
Ensembl chr 1:92,473,043...92,486,925 		JBrowse link
G GFI1B growth factor independent 1B transcriptional repressor decreases expression EXP pomalidomide results in decreased expression of GFI1B mRNA CTD PMID:15292067 NCBI chr 9:132,945,531...132,993,434
Ensembl chr 9:132,944,000...132,991,687 		JBrowse link
G ID1 inhibitor of DNA binding 1 increases expression EXP pomalidomide results in increased expression of ID1 mRNA CTD PMID:15292067 NCBI chr20:31,605,289...31,606,510
Ensembl chr20:31,605,283...31,606,515 		JBrowse link
G ID2 inhibitor of DNA binding 2 increases expression EXP pomalidomide results in increased expression of ID2 mRNA CTD PMID:15292067 NCBI chr 2:8,682,056...8,684,461
Ensembl chr 2:8,678,845...8,684,461 		JBrowse link
G IKZF1 IKAROS family zinc finger 1 multiple interactions EXP [pomalidomide co-treated with Dexamethasone] results in decreased expression of IKZF1 protein; afuresertib promotes the reaction [[pomalidomide co-treated with Dexamethasone] results in decreased expression of IKZF1 protein] CTD PMID:29928335 NCBI chr 7:50,303,455...50,405,101
Ensembl chr 7:50,304,068...50,405,101 		JBrowse link
G IKZF3 IKAROS family zinc finger 3 multiple interactions EXP [pomalidomide co-treated with Dexamethasone] results in decreased expression of IKZF3 protein; afuresertib promotes the reaction [[pomalidomide co-treated with Dexamethasone] results in decreased expression of IKZF3 protein] CTD PMID:29928335 NCBI chr17:39,757,715...39,864,312
Ensembl chr17:39,757,718...39,864,312 		JBrowse link
G IL10 interleukin 10 increases secretion EXP pomalidomide results in increased secretion of IL10 protein CTD PMID:15292067 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G IL13 interleukin 13 decreases secretion EXP pomalidomide results in decreased secretion of IL13 protein CTD PMID:15292067 NCBI chr 5:132,656,522...132,661,110
Ensembl chr 5:132,656,263...132,661,110 		JBrowse link
G IL2 interleukin 2 multiple interactions EXP Go 6976 inhibits the reaction [pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein]]; pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 mRNA]; pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein]; pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased secretion of IL2 protein]; rottlerin inhibits the reaction [pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein]] CTD PMID:16241859 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725 		JBrowse link
G IL5 interleukin 5 decreases secretion EXP pomalidomide results in decreased secretion of IL5 protein CTD PMID:15292067 NCBI chr 5:132,541,445...132,556,815
Ensembl chr 5:132,541,445...132,556,838 		JBrowse link
G IRF4 interferon regulatory factor 4 multiple interactions EXP [pomalidomide co-treated with Dexamethasone co-treated with afuresertib] results in decreased expression of IRF4 protein; [pomalidomide co-treated with Dexamethasone] results in decreased expression of IRF4 protein CTD PMID:29928335 NCBI chr 6:391,752...411,443
Ensembl chr 6:391,739...411,443 		JBrowse link
G JUND JunD proto-oncogene, AP-1 transcription factor subunit decreases expression EXP pomalidomide results in decreased expression of JUND mRNA CTD PMID:15292067 NCBI chr19:18,279,694...18,281,622
Ensembl chr19:18,279,694...18,281,622 		JBrowse link
G KLF1 KLF transcription factor 1 decreases expression EXP pomalidomide results in decreased expression of KLF1 mRNA CTD PMID:15292067 NCBI chr19:12,884,422...12,887,201
Ensembl chr19:12,884,422...12,887,201 		JBrowse link
G LMO2 LIM domain only 2 decreases expression EXP pomalidomide results in decreased expression of LMO2 mRNA CTD PMID:15292067 NCBI chr11:33,858,576...33,892,076
Ensembl chr11:33,858,576...33,892,076 		JBrowse link
G MEIS2 Meis homeobox 2 multiple interactions EXP pomalidomide inhibits the reaction [CRBN protein binds to and results in increased ubiquitination of and results in increased degradation of MEIS2 protein] CTD PMID:25043012 NCBI chr15:36,889,204...37,101,311
Ensembl chr15:36,889,204...37,101,299 		JBrowse link
G NFE2 nuclear factor, erythroid 2 decreases expression EXP pomalidomide results in decreased expression of NFE2 mRNA CTD PMID:15292067 NCBI chr12:54,292,111...54,301,015
Ensembl chr12:54,292,111...54,301,015 		JBrowse link
G PRKCQ protein kinase C theta multiple interactions EXP pomalidomide promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased activity of PRKCQ protein] CTD PMID:16241859 NCBI chr10:6,394,097...6,580,646
Ensembl chr10:6,427,143...6,580,301 		JBrowse link
G RAB28 RAB28, member RAS oncogene family multiple interactions EXP pomalidomide results in increased degradation of and results in decreased expression of RAB28 protein CTD PMID:30067223 NCBI chr 4:13,367,724...13,484,340
Ensembl chr 4:13,361,354...13,484,365 		JBrowse link
G SALL4 spalt like transcription factor 4 affects binding
multiple interactions		 EXP pomalidomide binds to [SALL4 protein binds to CRBN protein]
pomalidomide results in increased degradation of and results in decreased expression of SALL4 protein		 CTD PMID:30067223 NCBI chr20:51,782,331...51,802,521
Ensembl chr20:51,782,331...51,802,521 		JBrowse link
G SPI1 Spi-1 proto-oncogene increases expression
decreases expression		 EXP pomalidomide results in increased expression of SPI1 mRNA
pomalidomide results in decreased expression of SPI1 protein		 CTD PMID:15292067 PMID:16373662 NCBI chr11:47,354,860...47,378,547
Ensembl chr11:47,354,860...47,409,369 		JBrowse link
G WIZ WIZ zinc finger multiple interactions EXP pomalidomide results in increased degradation of and results in decreased expression of WIZ protein CTD PMID:30067223 NCBI chr19:15,419,978...15,449,956
Ensembl chr19:15,419,978...15,449,956 		JBrowse link
G ZBTB39 zinc finger and BTB domain containing 39 multiple interactions EXP pomalidomide results in increased degradation of and results in decreased expression of ZBTB39 protein CTD PMID:30067223 NCBI chr12:56,998,836...57,006,546
Ensembl chr12:56,998,836...57,006,546 		JBrowse link
G ZFP91 ZFP91 zinc finger protein, atypical E3 ubiquitin ligase multiple interactions EXP pomalidomide results in increased degradation of and results in decreased expression of ZFP91 protein CTD PMID:30067223 NCBI chr11:58,579,063...58,621,550
Ensembl chr11:58,579,063...58,621,550 		JBrowse link
G ZNF653 zinc finger protein 653 multiple interactions EXP pomalidomide results in increased degradation of and results in decreased expression of ZNF653 protein CTD PMID:30067223 NCBI chr19:11,483,429...11,505,839
Ensembl chr19:11,483,427...11,505,839 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26050
    role 25966
      application 25188
        anti-inflammatory agent 17801
          anti-inflammatory drug 15755
            thalidomide 479
              5-(2,2-diferuloylethen-1-yl)thalidomide 0
              5-[2-(feruloyl)ethen-1-yl]thalidomide 0
              pomalidomide 45
Path 2
Term Annotations click to browse term
  CHEBI ontology 26050
    subatomic particle 26025
      composite particle 26025
        hadron 26025
          baryon 26025
            nucleon 26025
              atomic nucleus 26025
                atom 26025
                  main group element atom 25850
                    p-block element atom 25850
                      carbon group element atom 25447
                        carbon atom 25405
                          organic molecular entity 25405
                            organic molecule 25233
                              organic cyclic compound 24287
                                organic heterocyclic compound 22334
                                  organic heteropolycyclic compound 21328
                                    organic heterobicyclic compound 18570
                                      benzopyrrole 10285
                                        isoindoles 1168
                                          phthalimides 1027
                                            2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione 479
                                              (R)-thalidomide 479
                                                thalidomide 479
                                                  5-(2,2-diferuloylethen-1-yl)thalidomide 0
                                                  5-[2-(feruloyl)ethen-1-yl]thalidomide 0
                                                  pomalidomide 45
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