Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: TNFRSF10B (TNF receptor superfamily member 10b) Homo sapiens
Symbol: TNFRSF10B
Name: TNF receptor superfamily member 10b
Description: Involved in cellular response to mechanical stimulus; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and positive regulation of I-kappaB kinase/NF-kappaB signaling. Localizes to the cell surface. Implicated in head and neck squamous cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: apoptosis inducing protein TRICK2A/2B; apoptosis inducing receptor TRAIL-R2; CD262; cytotoxic TRAIL receptor-2; death domain containing receptor for TRAIL/Apo-2L; death receptor 5; DR5; Fas-like protein; KILLER; KILLER/DR5; p53-regulated DNA damage-inducible cell death receptor(killer); TNF-related apoptosis-inducing ligand receptor 2; TRAIL-R2; TRAILR2; TRICK2; TRICK2A; TRICK2B; TRICKB; tumor necrosis factor receptor superfamily member 10B; tumor necrosis factor receptor superfamily, member 10b; tumor necrosis factor receptor-like protein ZTNFR9; ZTNFR9
Pan paniscus (bonobo/pygmy chimpanzee) : TNFRSF10B (TNF receptor superfamily member 10b)
Chlorocebus sabaeus (African green monkey) : TNFRSF10B (TNF receptor superfamily member 10b)
Heterocephalus glaber (naked mole-rat) : Tnfrsf10b (TNF receptor superfamily member 10b)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl823,020,133 - 23,069,031 (-)Ensembl
GRCh38823,020,133 - 23,069,031 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37822,877,646 - 22,926,700 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36822,933,591 - 22,982,637 (-)NCBINCBI36hg18NCBI36
Build 34822,933,595 - 22,982,637NCBI
Celera821,840,001 - 21,889,050 (-)NCBI
Cytogenetic Map8p21.3NCBI
HuRef821,422,101 - 21,471,002 (-)NCBIHuRef
CHM1_1823,079,836 - 23,128,790 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TNFRSF10B
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1346665
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-02-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.