FAS (Fas cell surface death receptor) - Rat Genome Database

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Gene: FAS (Fas cell surface death receptor) Homo sapiens
Symbol: FAS
Name: Fas cell surface death receptor
RGD ID: 1346266
HGNC Page HGNC:11920
Description: Enables calmodulin binding activity; identical protein binding activity; and kinase binding activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of protein metabolic process; and regulation of signal transduction. Acts upstream of or within apoptotic process. Located in several cellular components, including cell surface; membrane raft; and nuclear body. Part of CD95 death-inducing signaling complex. Implicated in several diseases, including autoimmune disease (multiple); cystic fibrosis; hematologic cancer (multiple); pre-eclampsia (multiple); and urinary system cancer (multiple). Biomarker of several diseases, including autoimmune disease (multiple); carcinoma (multiple); eye disease (multiple); hematologic cancer (multiple); and neurodegenerative disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: ALPS1A; APO-1; apo-1 antigen; APO-1 cell surface antigen; apoptosis antigen 1; apoptosis signaling receptor FAS; apoptosis-mediating surface antigen FAS; APT1; CD95; CD95 antigen; Delta Fas/APO-1/CD95; Fas (TNF receptor superfamily, member 6); FAS 827dupA; Fas AMA; Fas antigen; FAS receptor variant 9; FAS1; FASLG receptor; FASTM; mutant tumor necrosis receptor superfamily member 6; RP11-399O19.9; TNF receptor superfamily member 6; TNFRSF6; tumor necrosis factor receptor superfamily member 6; tumor necrosis factor receptor superfamily, member 6
RGD Orthologs
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: FAS (Gene ID: 355) and FASN (Gene ID: 2194) share the FAS symbol/alias in common. FAS is a widely used alternative name for fatty acid synthase (FASN), which can be confused with the official symbol for FAS (Fas cell surface death receptor, GeneID 355). [01 Jun 2018]
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381088,964,050 - 89,017,059 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1088,953,813 - 89,029,605 (+)EnsemblGRCh38hg38GRCh38
GRCh371090,750,555 - 90,776,816 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361090,740,268 - 90,765,522 (+)NCBINCBI36hg18NCBI36
Build 341090,740,267 - 90,765,521NCBI
Celera1084,497,075 - 84,522,333 (+)NCBI
Cytogenetic Map10q23.31NCBI
HuRef1084,384,755 - 84,410,009 (+)NCBIHuRef
CHM1_11091,032,348 - 91,057,602 (+)NCBICHM1_1
T2T-CHM13v2.01089,874,665 - 89,900,944 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
abdominal obesity-metabolic syndrome 1  (ISO)
Acute Experimental Pancreatitis  (ISO)
acute kidney failure  (IEP)
Acute Liver Failure  (EXP,IEP,IMP,ISO)
Acute Lung Injury  (EXP)
acute lymphoblastic leukemia  (IEP)
acute myeloid leukemia  (EXP,IAGP,IEP)
adult T-cell leukemia/lymphoma  (IAGP,IEP)
alcoholic hepatitis  (ISO)
Alcoholic Liver Diseases  (IEP)
Alzheimer's disease  (IAGP,IEP)
Animal Disease Models  (EXP)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (IEP)
aplastic anemia  (IEP)
asthma  (ISO)
atherosclerosis  (ISO)
autoimmune disease  (EXP)
autoimmune hepatitis  (IEP,ISO)
autoimmune lymphoproliferative syndrome  (EXP,IAGP,IDA,ISO)
Autoimmune Lymphoproliferative Syndrome, Type IA  (IAGP)
autoimmune thrombocytopenic purpura  (IEP)
B-Cell Chronic Lymphocytic Leukemia  (IEP)
Barrett's esophagus  (IEP)
Behcet's disease  (IEP)
brain glioma  (ISO)
Brain Injuries  (ISO)
brain ischemia  (ISO)
breast cancer  (IAGP)
breast carcinoma  (IEP)
cardiomyopathy  (EXP)
Cardiotoxicity  (EXP)
Cardiovascular Pregnancy Complications  (EXP)
cataract  (IEP)
Chemical and Drug Induced Liver Injury  (ISO)
Chest Trauma  (ISO)
chorioamnionitis  (IEP)
chronic conjunctivitis  (IEP)
chronic myeloid leukemia  (IAGP)
chronic obstructive pulmonary disease  (ISO)
Chronic Uveitis  (IEP)
clonorchiasis  (IEP)
Colonic Neoplasms  (ISO)
congestive heart failure  (IEP,ISO)
corneal neovascularization  (ISO)
cryptorchidism  (ISO)
cystic fibrosis  (IAGP)
dermatomyositis  (IEP)
diabetic angiopathy  (IEP)
Diabetic Nephropathies  (IEP,ISO)
diffuse large B-cell lymphoma  (EXP)
dilated cardiomyopathy  (EXP,ISO)
Disease Progression  (EXP)
endophthalmitis  (ISO)
Endotoxemia  (ISO)
Esophageal Neoplasms  (IEP)
esophagus adenocarcinoma  (IEP)
Experimental Allergic Asthma  (ISO)
Experimental Autoimmune Uveitis  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (EXP,ISO)
Experimental Liver Cirrhosis  (EXP,ISO)
Experimental Liver Neoplasms  (EXP)
Familial Thoracic Aortic Aneurysm 6  (IAGP)
Fetal Growth Retardation  (IAGP,IEP)
gastric ulcer  (ISO)
genetic disease  (IAGP)
glaucoma  (IEP)
glomerulonephritis  (EXP,ISO)
Graft vs Host Disease  (IEP)
Graves' disease  (IEP)
Hashimoto Disease  (IEP)
HELLP syndrome  (IAGP,ISO)
hematopoietic system disease  (EXP)
hepatitis B  (IEP)
hepatoblastoma  (IAGP,IEP)
hepatocellular carcinoma  (IEP,ISO)
heroin dependence  (ISO)
high grade glioma  (ISO)
human immunodeficiency virus infectious disease  (IDA)
Huntington's disease  (IEP)
Hyperoxia  (ISO)
hypersplenism  (EXP)
Hypothermia  (ISO)
Hypoxia-Ischemia, Brain  (ISO)
idiopathic pulmonary fibrosis  (ISO)
IgA glomerulonephritis  (ISO)
inclusion body myositis  (IEP)
infectious mononucleosis  (IEP)
Insulin Resistance  (ISO)
intrahepatic cholangiocarcinoma  (IEP)
Kashin-Beck Disease  (IEP)
Kidney Reperfusion Injury  (ISO)
limited scleroderma  (ISO)
liver disease  (ISO)
Liver Injury  (ISO)
Liver Reperfusion Injury  (ISO)
lung adenocarcinoma  (IEP)
Lung Neoplasms  (EXP)
lupus nephritis  (EXP)
Lymphatic Metastasis  (IAGP)
Lymphomatoid Papulosis  (EXP)
lymphoproliferative syndrome  (IAGP,ISO)
macular degeneration  (IEP)
male infertility  (ISO)
Mammary Neoplasms, Experimental  (ISO)
melanoma  (IAGP)
Metabolic Brain Diseases  (ISO)
mixed connective tissue disease  (IEP)
Moyamoya disease  (IAGP)
multiple sclerosis  (IAGP,IEP)
multiple system atrophy  (IEP)
Multisystemic Smooth Muscle Dysfunction Syndrome  (IAGP)
myasthenia gravis  (EXP,IEP)
myelodysplastic syndrome  (IEP)
Myocardial Reperfusion Injury  (ISO)
Nasal Polyps  (IEP)
nasal type extranodal NK/T-cell lymphoma  (IAGP)
Necrosis  (EXP)
Neoplasm Metastasis  (IEP,ISO)
nephritis  (EXP)
non-alcoholic fatty liver disease  (EXP)
ocular hypertension  (ISO)
ovarian cancer  (IEP)
Oxygen-Induced Retinopathy  (ISO)
Parkinson's disease  (IEP)
peripheral vascular disease  (IEP)
Plasmodium falciparum malaria  (EXP)
pre-eclampsia  (IAGP)
pre-malignant neoplasm  (ISO)
primary biliary cholangitis  (IEP)
primary cutaneous T-cell non-Hodgkin lymphoma  (EXP)
primary immunodeficiency disease  (IAGP)
prostate cancer  (IAGP,IEP)
Prostatic Neoplasms  (ISO)
proteinuria  (EXP)
Puromycin Aminonucleoside Nephrosis  (ISO)
Radiation Injuries, Experimental  (ISO)
relapsing-remitting multiple sclerosis  (IAGP)
renal cell carcinoma  (IAGP,IEP,ISO)
Reperfusion Injury  (ISO)
retinal detachment  (ISO)
retinoblastoma  (IEP)
rheumatoid arthritis  (IAGP,IEP,IMP)
sciatic neuropathy  (ISO)
seminoma  (IEP)
Sepsis  (ISO)
Sjogren's syndrome  (IEP,ISO,ISS)
Spinal Cord Compression  (IDA,IEP,ISO)
Spinal Cord Injuries  (ISO)
Splenomegaly  (EXP,IAGP)
squamous cell carcinoma  (IAGP)
systemic lupus erythematosus  (IAGP,IEP,ISS)
Taste Disorders  (EXP)
Temporomandibular Joint Osteoarthritis  (ISO)
Testicular Injury  (IEP)
thoracic aortic aneurysm  (IAGP)
transient cerebral ischemia  (ISO)
transitional cell carcinoma  (IEP)
type 1 diabetes mellitus  (IEP,ISO)
type 2 diabetes mellitus  (EXP)
ulcerative colitis  (ISO)
urinary bladder cancer  (EXP,IAGP)
varicocele  (ISO)
Ventricular Dysfunction, Left  (EXP)
Viral Bronchiolitis  (HEP)
visual epilepsy  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(-)-anisomycin  (EXP)
(-)-demecolcine  (EXP)
(R)-adrenaline  (EXP)
(R)-lipoic acid  (EXP)
(S)-colchicine  (ISO)
(S)-nicotine  (EXP,ISO)
(Z)-3-butylidenephthalide  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2,3,4,6-pentakis-O-galloyl-beta-D-glucose  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-nitropropane  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-diaminotoluene  (ISO)
2,4-dinitrotoluene  (ISO)
2,6-diaminotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-glucopyranose 6-phosphate  (ISO)
2-bromohexadecanoic acid  (EXP)
2-nitro-p-phenylenediamine  (ISO)
2-nitropropane  (ISO)
2-nitrotoluene  (ISO)
25-hydroxycholesterol  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (ISO)
4'-epidoxorubicin  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (EXP)
4-acetylaminofluorene  (ISO)
4-nitro-1,2-phenylenediamine  (ISO)
4-nitro-m-cresol  (EXP,ISO)
4-nitrophenol  (ISO)
4-nonylphenol  (ISO)
4-tert-butylphenol  (EXP)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-fluorouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
8'-apo-beta,psi-caroten-8'-al  (EXP)
9-cis-retinoic acid  (EXP)
[6]-Shogaol  (EXP)
acetamide  (ISO)
acetylsalicylic acid  (EXP,ISO)
acrolein  (EXP)
acrylamide  (ISO)
Actein  (ISO)
adefovir pivoxil  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine 6-phosphate  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-4-oxoretinoic acid  (EXP)
all-trans-4-oxoretinol  (EXP)
all-trans-acitretin  (EXP)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (EXP)
Aloe emodin  (EXP)
Aloperine  (ISO)
alpha-naphthoflavone  (ISO)
alpha-pinene  (EXP)
alpinumisoflavone  (EXP)
ammonium chloride  (ISO)
andrographolide  (EXP)
anthocyanin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
anthracen-2-amine  (ISO)
antimycin A  (EXP)
apigenin  (ISO)
apocynin  (ISO)
arachidonic acid  (EXP)
arecoline  (ISO)
arjunolic acid  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (EXP)
arsenous acid  (EXP)
artesunate  (EXP)
asbestos  (EXP)
atenolol  (EXP)
atorvastatin calcium  (ISO)
Aurothioglucose  (ISO)
benazepril  (ISO)
bentonite  (ISO)
benzene-1,2,4-triol  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
berberine  (EXP,ISO)
beta-carotene  (EXP)
beta-D-glucosamine 6-sulfate  (ISO)
Beta-Solamarine  (EXP)
bezafibrate  (EXP,ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (EXP)
bromochloroacetic acid  (ISO)
bucladesine  (ISO)
bufalin  (EXP)
buta-1,3-diene  (ISO)
butyric acid  (EXP)
Cacalol  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
Calcimycin  (EXP)
calcitriol  (EXP,ISO)
camptothecin  (EXP)
cannabidiol  (EXP,ISO)
capsaicin  (EXP,ISO)
carbamazepine  (EXP)
carbon nanotube  (EXP,ISO)
carboplatin  (EXP)
carnosic acid  (ISO)
carvedilol  (EXP)
casticin  (EXP)
catechol  (EXP)
celastrol  (EXP)
celecoxib  (EXP)
cetrorelix  (ISO)
CGP 52608  (EXP)
charcoal  (ISO)
chlorambucil  (EXP)
chloroacetaldehyde  (EXP)
chloroprene  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP,ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysazin  (EXP)
cidofovir anhydrous  (EXP)
Cinobufotalin  (EXP)
cisplatin  (EXP,ISO)
clobetasol  (ISO)
clodronic acid  (EXP)
clofazimine  (ISO)
clofibrate  (ISO)
clorgyline  (EXP)
clotrimazole  (ISO)
clozapine  (ISO)
cobalt atom  (EXP)
cobalt dichloride  (EXP)
cocaine  (EXP)
copanlisib  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (EXP)
corosolic acid  (EXP)
cortisol  (EXP,ISO)
crocidolite asbestos  (ISO)
Cuprizon  (ISO)
curcumin  (EXP)
cycloheximide  (EXP,ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP)
cylindrospermopsin  (EXP)
cypermethrin  (EXP)
cyproconazole  (ISO)
cytarabine  (EXP,ISO)
D-glucose  (EXP)
daunorubicin  (EXP)
decabromodiphenyl ether  (EXP)
deguelin  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
Diallyl sulfide  (EXP)
diallyl trisulfide  (EXP)
diamminedichloroplatinum  (EXP)
diarsenic trioxide  (EXP)
diazinon  (EXP,ISO)
dibenzo[a,l]pyrene  (EXP)
dibromoacetic acid  (ISO)
dichlorine  (ISO)
dichlorvos  (ISO)
diclofenac  (EXP,ISO)
diethylstilbestrol  (ISO)
dihydroartemisinin  (ISO)
dimethyl sulfoxide  (EXP)
dimethylarsinic acid  (EXP)
dioscin  (EXP)
diosgenin  (EXP)
dioxygen  (EXP,ISO)
diuron  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
EC (peptidyl-dipeptidase A) inhibitor  (ISO)
Echimidine  (EXP)
elemental selenium  (EXP)
emodin  (EXP,ISO)
endosulfan  (ISO)
enilconazole  (EXP)
entinostat  (EXP)
epoxiconazole  (ISO)
esculetin  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (EXP)
etoposide  (EXP,ISO)
fenofibrate  (EXP,ISO)
ferrosoferric oxide  (EXP)
fingolimod hydrochloride  (ISO)
flavanone  (EXP)
flavonoids  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (EXP,ISO)
fotemustine  (EXP)
fructose  (EXP,ISO)
fumonisin B1  (EXP)
furan  (ISO)
Fusarenone X  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gemcitabine  (EXP)
genistein  (EXP,ISO)
gentamycin  (ISO)
gibberellin A3  (ISO)
gingerol  (ISO)
ginsenoside Re  (EXP,ISO)
glucose  (EXP)
glutathione  (ISO)
glutathione disulfide  (ISO)
glyphosate  (EXP)
gold atom  (EXP)
gold(0)  (EXP)
gossypol  (ISO)
GSK690693  (EXP)
guggulsterone  (ISO)
GW 4064  (ISO)
Heliotrine  (EXP,ISO)
heparin  (EXP)
heroin  (EXP)
hexachlorobenzene  (ISO)
hexadecanoic acid  (EXP,ISO)
Honokiol  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
hydroquinone  (EXP)
hydroxychloroquine  (EXP)
hydroxyurea  (EXP,ISO)
hyperforin  (EXP)
ibuprofen  (EXP)
ICI D1694  (EXP)
idelalisib  (EXP,ISO)
inulin  (ISO)
irinotecan  (EXP)
isoflavones  (ISO)
isoprenaline  (ISO)
ivermectin  (EXP)
ketoconazole  (EXP,ISO)
L-methionine  (ISO)
lansoprazole  (ISO)
Lasiocarpine  (EXP)
lead diacetate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
leukotriene D4  (EXP)
Licochalcone A  (EXP)
lipoic acid  (EXP)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
lithocholic acid  (EXP)
lovastatin  (EXP)
luteolin  (ISO)
LY294002  (EXP)
magnesium oxide  (EXP)
mancozeb  (EXP)
maneb  (ISO)
manganese(II) chloride  (ISO)
mangiferin  (EXP)
masoprocol  (EXP)
medroxyprogesterone acetate  (EXP)
melatonin  (EXP,ISO)
melittin  (EXP)
menadione  (EXP)
mercury atom  (EXP)
mercury dibromide  (EXP)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP)
metformin  (ISO)
methamphetamine  (ISO)
methotrexate  (EXP)
methoxychlor  (ISO)
methyl methanesulfonate  (EXP)
methylarsonic acid  (EXP)
methylmercury chloride  (EXP)
methyltestosterone  (ISO)
mifepristone  (EXP)
miquelianin  (ISO)
mitogen  (EXP)
mitomycin C  (EXP)
mitoxantrone  (EXP)
MK-2206  (EXP)
montelukast  (EXP)
morin  (ISO)
morphine  (EXP,ISO)
myriocin  (EXP)
Myrtucommulone A  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (EXP)
naproxen  (ISO)
naringin  (EXP)
nickel atom  (EXP)
nickel dichloride  (ISO)
niclosamide  (ISO)
nicotine  (EXP,ISO)
nitric oxide  (EXP)
nitrobenzene  (ISO)
nitroglycerin  (EXP)
Nodularin  (EXP)
notoginsenoside R1  (ISO)
Nutlin-3  (EXP)
nystatin  (EXP)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
octreotide  (EXP)
okadaic acid  (EXP,ISO)
oleic acid  (EXP,ISO)
olmesartan  (ISO)
orlistat  (EXP)
osthole  (EXP)
ouabain  (EXP)
ozone  (EXP,ISO)
p-menthan-3-ol  (EXP)
paclitaxel  (EXP,ISO)
Panduratin A  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parthenolide  (EXP)
pemetrexed  (EXP)
Pentoxifylline  (EXP)
perfluorodecanoic acid  (EXP)
perfluorohexanesulfonic acid  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluoroundecanoic acid  (EXP)