Gene: SOX17 (SRY-box transcription factor 17) Homo sapiens
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Symbol:
SOX17
Name:
SRY-box transcription factor 17
Description:
Exhibits beta-catenin binding activity and transcription factor binding activity. Involved in several processes, including animal organ development; mRNA transcription by RNA polymerase II; and protein destabilization. Localizes to the nucleus and transcription factor complex. Implicated in vesicoureteral reflux.
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
FLJ22252; SRY (sex determining region Y)-box 17; SRY box 17; SRY-box 17; SRY-related HMG-box transcription factor SOX17; transcription factor SOX-17; VUR3
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Mus musculus (house mouse):
Sox17 (SRY (sex determining region Y)-box 17) HGNC
Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB
Rattus norvegicus (Norway rat):
Sox17 (SRY-box transcription factor 17) HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB
Chinchilla lanigera (long-tailed chinchilla):
Sox17 (SRY-box transcription factor 17) NCBI
Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):
SOX17 (SRY-box transcription factor 17) NCBI
Ortholog
Canis lupus familiaris (dog):
SOX17 (SRY-box transcription factor 17) HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Sox17 (SRY-box transcription factor 17) NCBI
Ortholog
Sus scrofa (pig):
SOX17 (SRY-box transcription factor 17) HGNC
Ensembl, NCBI, OMA, OrthoDB, Panther
Chlorocebus sabaeus (green monkey):
SOX17 (SRY-box transcription factor 17) NCBI
Ortholog
Heterocephalus glaber (naked mole-rat):
Sox17 (SRY-box transcription factor 17) NCBI
Ortholog
Other homologs 2
Rattus norvegicus (Norway rat):
Sox7 (SRY-box transcription factor 7) HGNC
OrthoDB
Rattus norvegicus (Norway rat):
Sox18 (SRY-box transcription factor 18) HGNC
OrthoDB
Mus musculus (house mouse):
Sox7 (SRY (sex determining region Y)-box 7) HGNC
OrthoDB
Mus musculus (house mouse):
Sox18 (SRY (sex determining region Y)-box 18) HGNC
OrthoDB
Canis lupus familiaris (dog):
SOX7 (SRY-box transcription factor 7) HGNC
OrthoDB
Canis lupus familiaris (dog):
SOX18 (SRY-box transcription factor 18) HGNC
OrthoDB
Sus scrofa (pig):
SOX18 (SRY-box transcription factor 18) HGNC
OrthoDB
Sus scrofa (pig):
SOX7 (SRY-box transcription factor 7) HGNC
OrthoDB
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Sox17 (SRY-box transcription factor 17)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Mus musculus (house mouse):
Sox17 (SRY (sex determining region Y)-box 17)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup)
Danio rerio (zebrafish):
sox17 (SRY (sex determining region Y)-box 17)
Alliance
DIOPT (Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, ZFIN)
Caenorhabditis elegans (roundworm):
sem-2
Alliance
DIOPT (InParanoid, OrthoFinder, Roundup)
Saccharomyces cerevisiae (baker's yeast):
ROX1
Alliance
DIOPT (OrthoFinder, Roundup)
Caenorhabditis elegans (roundworm):
sox-2
Alliance
DIOPT (OrthoFinder, PhylomeDB, Roundup)
Drosophila melanogaster (fruit fly):
Sox15
Alliance
DIOPT (Ensembl Compara, OrthoFinder, OrthoInspector, PANTHER, Roundup)
Allele / Splice:
See ClinVar data
Latest Assembly:
GRCh38 - Human Genome Assembly GRCh38
Position:
Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 Ensembl 8 54,457,935 - 54,460,892 (+) Ensembl GRCh38 8 54,457,935 - 54,460,892 (+) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh37 8 55,370,495 - 55,373,456 (+) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 8 55,533,048 - 55,536,009 (+) NCBI NCBI36 hg18 NCBI36 Build 34 8 55,533,047 - 55,535,484 NCBI Celera 8 51,361,039 - 51,364,000 (+) NCBI Cytogenetic Map 8 q11.23 NCBI HuRef 8 50,838,617 - 50,841,578 (+) NCBI HuRef CHM1_1 8 55,422,260 - 55,425,221 (+) NCBI CHM1_1
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
vesicoureteral reflux IAGP RGD:13529225 8554872 ClinVar Annotator: match by term: Vesico-Ureteral Reflux ClinVar PMID:25741868 Vesicoureteral Reflux 3 IAGP RGD:8555965 8554872 ClinVar Annotator: match by term: Vesicoureteral reflux 3 ClinVar PMID:20960469 Vesicoureteral Reflux 3 IAGP RGD:8555964 8554872 ClinVar Annotator: match by term: Vesicoureteral reflux 3 ClinVar PMID:20960469 , PMID:25741868 Vesicoureteral Reflux 3 IAGP RGD:8555963 8554872 ClinVar Annotator: match by term: Vesicoureteral reflux 3 ClinVar PMID:20960469 more ...
Imported Annotations - CTD
Colorectal Neoplasms EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18413743 Teratogenesis EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:24154490 vesicoureteral reflux EXP 11554173 CTD Direct Evidence: marker/mechanism CTD Imported Annotations - MGI
biliary atresia ISS RGD:1313359 13592920 MouseDO Imported Annotations - OMIM
Vesicoureteral Reflux 3 IAGP 7240710 OMIM
1,1-dichloroethene decreases expression ISO RGD:1313359 6480464 vinylidene chloride results in decreased expression of SOX17 mRNA CTD PMID:26682919 17beta-estradiol decreases expression ISO RGD:1313359 6480464 Estradiol results in decreased expression of SOX17 mRNA CTD PMID:25210133 17beta-estradiol multiple interactions ISO RGD:1313359 6480464 ESR1 protein promotes the reaction [Estradiol results in decreased expression of SOX17 mRNA] CTD PMID:25210133 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1313359 6480464 Tetrachlorodibenzodioxin results in increased expression of SOX17 mRNA CTD PMID:19770486 , PMID:24058054 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1313359 6480464 Tetrachlorodibenzodioxin affects the expression of SOX17 mRNA CTD PMID:26377647 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1313359 6480464 [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of SOX17 mRNA CTD PMID:25975270 3-methylcholanthrene multiple interactions ISO RGD:1313359 6480464 [Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of SOX17 mRNA CTD PMID:23519560 4,4'-diaminodiphenylmethane affects expression ISO RGD:1313359 6480464 4, 4'-diaminodiphenylmethane affects the expression of SOX17 mRNA CTD PMID:18648102 4,4'-sulfonyldiphenol increases expression ISO RGD:1313359 6480464 bis(4-hydroxyphenyl)sulfone results in increased expression of SOX17 mRNA CTD PMID:30951980 4-hydroxyphenyl retinamide increases expression ISO RGD:1313359 6480464 Fenretinide results in increased expression of SOX17 mRNA CTD PMID:28973697 5-aza-2'-deoxycytidine decreases methylation EXP 6480464 Decitabine results in decreased methylation of SOX17 promoter CTD PMID:18413743 5-aza-2'-deoxycytidine increases expression EXP 6480464 Decitabine results in increased expression of SOX17 mRNA, Decitabine results in increased expression of SOX17 protein CTD PMID:18413743 5-bromo-2'-deoxyuridine decreases localization EXP 6480464 Bromodeoxyuridine results in decreased localization of SOX17 protein CTD PMID:24154490 5-fluorouracil decreases expression ISO RGD:1313359 6480464 Fluorouracil results in decreased expression of SOX17 protein CTD PMID:21296659 5-fluorouracil decreases expression EXP 6480464 Fluorouracil results in decreased expression of SOX17 mRNA CTD PMID:24737281 5-fluorouracil decreases localization EXP 6480464 Fluorouracil results in decreased localization of SOX17 protein CTD PMID:24154490 6-aminonicotinamide decreases localization EXP 6480464 6-Aminonicotinamide results in decreased localization of SOX17 protein CTD PMID:24154490 6-propyl-2-thiouracil decreases expression ISO RGD:1305371 6480464 Propylthiouracil results in decreased expression of SOX17 mRNA CTD PMID:24780913 acetic acid decreases expression ISO RGD:1313359 6480464 Acetic Acid results in decreased expression of SOX17 protein CTD PMID:21296659 actinomycin D decreases localization EXP 6480464 Dactinomycin results in decreased localization of SOX17 protein CTD PMID:24154490 aflatoxin B1 decreases expression EXP 6480464 Aflatoxin B1 results in decreased expression of SOX17 mRNA CTD PMID:22100608 aflatoxin B1 decreases methylation EXP 6480464 Aflatoxin B1 results in decreased methylation of SOX17 gene CTD PMID:27153756 all-trans-retinoic acid increases expression ISO RGD:1313359 6480464 Tretinoin results in increased expression of SOX17 mRNA CTD PMID:16236135 all-trans-retinoic acid decreases localization EXP 6480464 Tretinoin results in decreased localization of SOX17 protein CTD PMID:24154490 all-trans-retinol multiple interactions ISO RGD:1313359 6480464 [Vitamin A co-treated with INHBA protein] results in increased expression of SOX17 mRNA CTD PMID:17244017 arsenite(3-) increases methylation EXP 6480464 arsenite results in increased methylation of SOX17 promoter CTD PMID:23974009 benzo[a]pyrene decreases expression ISO RGD:1305371 6480464 Benzo(a)pyrene results in decreased expression of SOX17 mRNA CTD PMID:21839799 benzo[a]pyrene multiple interactions ISO RGD:1313359 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of SOX17 mRNA CTD PMID:27858113 benzo[a]pyrene increases expression ISO RGD:1313359 6480464 Benzo(a)pyrene results in increased expression of SOX17 mRNA CTD PMID:19770486 , PMID:22228805 benzo[b]fluoranthene increases expression ISO RGD:1313359 6480464 benzo(b)fluoranthene results in increased expression of SOX17 mRNA CTD PMID:26377693 benzo[b]fluoranthene multiple interactions ISO RGD:1313359 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of SOX17 mRNA CTD PMID:27858113 Benzo[k]fluoranthene increases expression ISO RGD:1313359 6480464 benzo(k)fluoranthene results in increased expression of SOX17 mRNA CTD PMID:26377693 bis(2-ethylhexyl) phthalate multiple interactions ISO RGD:1305371 6480464 [Diethylhexyl Phthalate co-treated with Genistein] results in decreased expression of SOX17 mRNA CTD PMID:25031359 bisphenol A increases expression ISO RGD:1313359 6480464 bisphenol A results in increased expression of SOX17 mRNA CTD PMID:24090592 , PMID:30951980 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of SOX17 mRNA CTD PMID:27271280 bisphenol A increases methylation ISO RGD:1305371 6480464 bisphenol A results in increased methylation of SOX17 gene CTD PMID:28505145 bisphenol A decreases expression ISO RGD:1305371 6480464 bisphenol A results in decreased expression of SOX17 mRNA CTD PMID:25181051 , PMID:30816183 bisphenol F increases expression ISO RGD:1313359 6480464 bisphenol F results in increased expression of SOX17 mRNA CTD PMID:30951980 bromochloroacetic acid decreases expression ISO RGD:1313359 6480464 bromochloroacetic acid results in decreased expression of SOX17 protein CTD PMID:21296659 buta-1,3-diene decreases expression ISO RGD:1313359 6480464 1, 3-butadiene results in decreased expression of SOX17 mRNA CTD PMID:29038090 butanal increases expression EXP 6480464 butyraldehyde results in increased expression of SOX17 mRNA CTD PMID:26079696 C60 fullerene increases expression ISO RGD:1305371 6480464 fullerene C60 results in increased expression of SOX17 mRNA CTD PMID:19167457 calciol increases expression ISO RGD:1313359 6480464 Cholecalciferol results in increased expression of SOX17 mRNA, Cholecalciferol results in increased expression of SOX17 protein CTD PMID:17170073 camptothecin increases methylation EXP 6480464 Camptothecin results in increased methylation of SOX17 gene CTD PMID:30720231 carbamazepine affects expression EXP 6480464 Carbamazepine affects the expression of SOX17 mRNA CTD PMID:25979313 carbon nanotube increases expression ISO RGD:1313359 6480464 Nanotubes, Carbon analog results in increased expression of SOX17 mRNA, Nanotubes, Carbon results in increased expression of SOX17 mRNA CTD PMID:25554681 Chlorophacinone decreases localization EXP 6480464 chlorophacinone results in decreased localization of SOX17 protein CTD PMID:24154490 chloroprene decreases expression ISO RGD:1313359 6480464 Chloroprene results in decreased expression of SOX17 mRNA CTD PMID:23125180 chrysene multiple interactions ISO RGD:1313359 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of SOX17 mRNA CTD PMID:27858113 columbamine decreases expression EXP 6480464 columbamine results in decreased expression of SOX17 mRNA CTD PMID:23124089 diethylstilbestrol increases expression EXP 6480464 Diethylstilbestrol results in increased expression of SOX17 mRNA CTD PMID:19371625 diethylstilbestrol decreases localization EXP 6480464 Diethylstilbestrol results in decreased localization of SOX17 protein CTD PMID:24154490 dimethyl sulfoxide decreases expression EXP 6480464 Dimethyl Sulfoxide results in decreased expression of SOX17 mRNA CTD PMID:22105179 diniconazole decreases localization EXP 6480464 diniconazole results in decreased localization of SOX17 protein CTD PMID:24154490 dinoseb decreases localization EXP 6480464 dinoseb results in decreased localization of SOX17 protein CTD PMID:24154490 diquat decreases localization EXP 6480464 Diquat results in decreased localization of SOX17 protein CTD PMID:24154490 dorsomorphin decreases localization EXP 6480464 dorsomorphin results in decreased localization of SOX17 protein CTD PMID:24154490 dorsomorphin multiple interactions EXP 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOX17 mRNA CTD PMID:27188386 doxorubicin decreases localization EXP 6480464 Doxorubicin results in decreased localization of SOX17 protein CTD PMID:24154490 endosulfan increases expression ISO RGD:1305371 6480464 Endosulfan results in increased expression of SOX17 mRNA CTD PMID:29391264 fluazinam decreases localization EXP 6480464 fluazinam results in decreased localization of SOX17 protein CTD PMID:24154490 flusilazole decreases localization EXP 6480464 flusilazole results in decreased localization of SOX17 protein CTD PMID:24154490 gefitinib decreases localization EXP 6480464 gefitinib results in decreased localization of SOX17 protein CTD PMID:24154490 genistein multiple interactions ISO RGD:1305371 6480464 [Diethylhexyl Phthalate co-treated with Genistein] results in decreased expression of SOX17 mRNA CTD PMID:25031359 hexaconazole decreases localization EXP 6480464 hexaconazole results in decreased localization of SOX17 protein CTD PMID:24154490 Indeno[1,2,3-cd]pyrene decreases expression ISO RGD:1313359 6480464 indeno(1 more ... CTD PMID:26377693 isoprenaline increases expression ISO RGD:1313359 6480464 Isoproterenol results in increased expression of SOX17 mRNA CTD PMID:20003209 isotretinoin decreases localization EXP 6480464 Isotretinoin results in decreased localization of SOX17 protein CTD PMID:24154490 lipopolysaccharide increases expression ISO RGD:1313359 6480464 Lipopolysaccharides results in increased expression of SOX17 mRNA CTD PMID:10975854 maleic acid increases expression EXP 6480464 maleic acid results in increased expression of SOX17 mRNA CTD PMID:28392987 methamphetamine multiple interactions ISO RGD:1305371 6480464 [Methamphetamine co-treated with SCH 23390] results in decreased expression of SOX17 mRNA CTD PMID:19564919 methamphetamine decreases expression ISO RGD:1305371 6480464 Methamphetamine results in decreased expression of SOX17 mRNA CTD PMID:19564919 mianserin decreases localization EXP 6480464 Mianserin results in decreased localization of SOX17 protein CTD PMID:24154490 mifepristone decreases expression ISO RGD:1305371 6480464 Mifepristone results in decreased expression of SOX17 mRNA CTD PMID:25972201 N-nitrosodiethylamine decreases expression EXP 6480464 Diethylnitrosamine results in decreased expression of SOX17 mRNA CTD PMID:21527772 naphthalene increases expression ISO RGD:1313359 6480464 naphthalene results in increased expression of SOX17 protein CTD PMID:16239640 oxaliplatin multiple interactions ISO RGD:1305371 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of SOX17 mRNA CTD PMID:25729387 paracetamol affects expression ISO RGD:1313359 6480464 Acetaminophen affects the expression of SOX17 mRNA CTD PMID:17562736 paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of SOX17 mRNA CTD PMID:22230336 paraquat increases expression ISO RGD:1313359 6480464 Paraquat results in increased expression of SOX17 mRNA CTD PMID:12595580 perfluorooctane-1-sulfonic acid decreases expression ISO RGD:1313359 6480464 perfluorooctane sulfonic acid results in decreased expression of SOX17 mRNA CTD PMID:25510869 phenobarbital affects expression ISO RGD:1313359 6480464 Phenobarbital affects the expression of SOX17 mRNA CTD PMID:23091169 phenylmercury acetate multiple interactions EXP 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOX17 mRNA CTD PMID:27188386 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:1313359 6480464 [Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of SOX17 mRNA CTD PMID:23519560 resveratrol decreases expression EXP 6480464 resveratrol results in decreased expression of SOX17 mRNA CTD PMID:19371625 resveratrol decreases expression ISO RGD:1305371 6480464 resveratrol results in decreased expression of SOX17 mRNA CTD PMID:25905778 ritanserin decreases localization EXP 6480464 Ritanserin results in decreased localization of SOX17 protein CTD PMID:24154490 SB 431542 decreases localization EXP 6480464 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased localization of SOX17 protein CTD PMID:24154490 SB 431542 multiple interactions EXP 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SOX17 mRNA CTD PMID:27188386 SCH 23390 multiple interactions ISO RGD:1305371 6480464 [Methamphetamine co-treated with SCH 23390] results in decreased expression of SOX17 mRNA CTD PMID:19564919 silicon dioxide decreases expression EXP 6480464 Silicon Dioxide analog results in decreased expression of SOX17 mRNA CTD PMID:25895662 sorafenib decreases localization EXP 6480464 sorafenib results in decreased localization of SOX17 protein CTD PMID:24154490 sunitinib decreases localization EXP 6480464 sunitinib results in decreased localization of SOX17 protein CTD PMID:24154490 tetrachloroethene decreases expression ISO RGD:1313359 6480464 Tetrachloroethylene results in decreased expression of SOX17 mRNA CTD PMID:28973375 tetraphene increases expression ISO RGD:1313359 6480464 benz(a)anthracene results in increased expression of SOX17 mRNA CTD PMID:26377693 tetraphene multiple interactions ISO RGD:1313359 6480464 [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of SOX17 mRNA CTD PMID:27858113 thalidomide decreases localization EXP 6480464 Thalidomide results in decreased localization of SOX17 protein CTD PMID:24154490 titanium dioxide increases expression ISO RGD:1313359 6480464 titanium dioxide results in increased expression of SOX17 mRNA CTD PMID:23557971 toluene increases expression ISO RGD:1305371 6480464 Toluene results in increased expression of SOX17 mRNA CTD PMID:22967744 topotecan multiple interactions ISO RGD:1305371 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of SOX17 mRNA CTD PMID:25729387 trichloroethene decreases methylation ISO RGD:1305371 6480464 Trichloroethylene results in decreased methylation of SOX17 gene CTD PMID:27618143 trichloroethene decreases expression ISO RGD:1313359 6480464 Trichloroethylene results in decreased expression of SOX17 mRNA CTD PMID:28013219 triclosan decreases expression EXP 6480464 Triclosan results in decreased expression of SOX17 mRNA CTD PMID:30510588 trimellitic anhydride decreases expression ISO RGD:1313359 6480464 trimellitic anhydride results in decreased expression of SOX17 mRNA CTD PMID:19042947 valproic acid decreases localization EXP 6480464 Valproic Acid results in decreased localization of SOX17 protein CTD PMID:24154490 valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of SOX17 mRNA CTD PMID:25979313 vandetanib decreases localization EXP 6480464 N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine results in decreased localization of SOX17 protein CTD PMID:24154490 vinclozolin affects expression ISO RGD:1305371 6480464 vinclozolin affects the expression of SOX17 mRNA CTD PMID:19015723 ziprasidone decreases localization EXP 6480464 ziprasidone results in decreased localization of SOX17 protein CTD PMID:24154490 zoledronic acid increases expression EXP 6480464 zoledronic acid results in increased expression of SOX17 mRNA CTD PMID:24714768
Biological Process anatomical structure morphogenesis IBA FB:FBgn0000411 more ... 2290271 (PMID:21873635) GO_Central PMID:21873635 angiogenesis ISS UniProtKB:Q61473 2290271 BHF-UCL GO_REF:0000024 angiogenesis IBA MGI:MGI:107543 , PANTHER:PTN000030701 2290271 (PMID:21873635) GO_Central PMID:21873635 cardiac cell fate determination IMP 2290271 (PMID:19736317) BHF-UCL PMID:19736317 cardiogenic plate morphogenesis ISS UniProtKB:Q61473 2290271 BHF-UCL GO_REF:0000024 cell differentiation IBA MGI:MGI:103559 more ... 2290271 (PMID:21873635) GO_Central PMID:21873635 cell migration involved in gastrulation IEA UniProtKB:Q61473 , ensembl:ENSMUSP000000270352290271 Ensembl GO_REF:0000107 cellular response to leukemia inhibitory factor IEA UniProtKB:Q61473 , ensembl:ENSMUSP000000270352290271 Ensembl GO_REF:0000107 common bile duct development IEA UniProtKB:Q61473 , ensembl:ENSMUSP000000270352290271 Ensembl GO_REF:0000107 embryonic foregut morphogenesis ISS UniProtKB:Q61473 2290271 BHF-UCL GO_REF:0000024 embryonic heart tube development ISS UniProtKB:Q61473 2290271 BHF-UCL GO_REF:0000024 embryonic heart tube morphogenesis ISS UniProtKB:Q61473 2290271 BHF-UCL GO_REF:0000024 endocardial cell differentiation ISS UniProtKB:Q61473 2290271 BHF-UCL GO_REF:0000024 endocardium formation ISS UniProtKB:Q61473 2290271 BHF-UCL GO_REF:0000024 endoderm formation IDA 2290271 (PMID:18682240) UniProtKB PMID:18682240 endodermal cell fate determination IEA UniProtKB:Q61473 , ensembl:ENSMUSP000000270352290271 Ensembl GO_REF:0000107 endodermal digestive tract morphogenesis ISS UniProtKB:Q61473 2290271 BHF-UCL GO_REF:0000024 gall bladder development IEA UniProtKB:Q61473 , ensembl:ENSMUSP000000270352290271 Ensembl GO_REF:0000107 heart development IBA MGI:MGI:107543 , PANTHER:PTN000030701 2290271 (PMID:21873635) GO_Central PMID:21873635 heart formation TAS 2290271 (PMID:19736317) BHF-UCL PMID:19736317 heart looping ISS UniProtKB:Q61473 2290271 BHF-UCL GO_REF:0000024 inner cell mass cellular morphogenesis IEA UniProtKB:Q61473 , ensembl:ENSMUSP000000270352290271 Ensembl GO_REF:0000107 metanephros development IMP 2290271 (PMID:20960469) BHF-UCL PMID:20960469 mRNA transcription by RNA polymerase II IDA 2290271 (PMID:22292085) BHF-UCL PMID:22292085 negative regulation of canonical Wnt signaling pathway IMP 2290271 (PMID:18413743), (PMID:20960469) BHF-UCL PMID:18413743 , PMID:20960469 negative regulation of cell growth IMP 2290271 (PMID:18413743) BHF-UCL PMID:18413743 negative regulation of Wnt signaling pathway involved in heart development IEA UniProtKB:Q61473 , ensembl:ENSMUSP000000270352290271 Ensembl GO_REF:0000107 outflow tract morphogenesis ISS UniProtKB:Q61473 2290271 BHF-UCL GO_REF:0000024 positive regulation of cell differentiation IEA UniProtKB:Q61473 , ensembl:ENSMUSP000000270352290271 Ensembl GO_REF:0000107 positive regulation of protein catabolic process IEA UniProtKB:Q61473 , ensembl:ENSMUSP000000270352290271 Ensembl GO_REF:0000107 positive regulation of transcription by RNA polymerase II IDA 2290271 (PMID:22292085) BHF-UCL PMID:22292085 positive regulation of transcription by RNA polymerase II IBA MGI:MGI:107543 more ... 2290271 (PMID:21873635) GO_Central PMID:21873635 positive regulation of transcription, DNA-templated ISS UniProtKB:Q61473 2290271 BHF-UCL GO_REF:0000024 protein destabilization IMP 2290271 (PMID:17875931) BHF-UCL PMID:17875931 protein stabilization IMP 2290271 (PMID:17875931) BHF-UCL PMID:17875931 regulation of cardiac cell fate specification IEA UniProtKB:Q61473 , ensembl:ENSMUSP000000270352290271 Ensembl GO_REF:0000107 regulation of embryonic development ISS UniProtKB:Q61473 2290271 UniProtKB GO_REF:0000024 regulation of stem cell division IEA UniProtKB:Q61473 , ensembl:ENSMUSP000000270352290271 Ensembl GO_REF:0000107 regulation of stem cell proliferation IEA UniProtKB:Q61473 , ensembl:ENSMUSP000000270352290271 Ensembl GO_REF:0000107 regulation of transcription from RNA polymerase II promoter involved in definitive endodermal cell fate specification ISS UniProtKB:Q61473 2290271 BHF-UCL GO_REF:0000024 regulation of transcription, DNA-templated IBA FB:FBgn0000411 more ... 2290271 (PMID:21873635) GO_Central PMID:21873635 regulation of transcription, DNA-templated ISS UniProtKB:Q61473 2290271 UniProtKB GO_REF:0000024 rostrocaudal neural tube patterning IEA UniProtKB:Q61473 , ensembl:ENSMUSP000000270352290271 Ensembl GO_REF:0000107 signal transduction involved in regulation of gene expression IEA UniProtKB:Q61473 , ensembl:ENSMUSP000000270352290271 Ensembl GO_REF:0000107 spermatogenesis IEA UniProtKB:Q61473 , ensembl:ENSMUSP000000270352290271 Ensembl GO_REF:0000107 stem cell fate specification IEA UniProtKB:Q61473 , ensembl:ENSMUSP000000270352290271 Ensembl GO_REF:0000107 ureter development IMP 2290271 (PMID:20960469) BHF-UCL PMID:20960469 vasculogenesis ISS UniProtKB:Q61473 2290271 BHF-UCL GO_REF:0000024 vasculogenesis IBA MGI:MGI:107543 , PANTHER:PTN000030701 2290271 (PMID:21873635) GO_Central PMID:21873635 Wnt signaling pathway IEA UniProtKB-KW:KW-0879 2290271 UniProt GO_REF:0000037 Cellular Component nuclear chromatin ISA tfclass:4.1.1 2290271 NTNU_SB GO_REF:0000113 nuclear transcription factor complex IBA MGI:MGI:103559 more ... 2290271 (PMID:21873635) GO_Central PMID:21873635 nucleoplasm TAS 2290271 Reactome Reactome:R-HSA-5626938, Reactome:R-HSA-5665608 nucleus IDA 2290271 (PMID:17875931), (PMID:18682240) BHF-UCL PMID:17875931 , PMID:18682240 nucleus IBA FB:FBgn0000411 more ... 2290271 (PMID:21873635) GO_Central PMID:21873635 transcription factor complex IDA 2290271 (PMID:19736317) BHF-UCL PMID:19736317 Molecular Function beta-catenin binding IPI UniProtKB:P35222 2290271 (PMID:17875931) BHF-UCL PMID:17875931 DNA-binding transcription activator activity, RNA polymerase II-specific IBA MGI:MGI:107543 , PANTHER:PTN000030701 2290271 (PMID:21873635) GO_Central PMID:21873635 DNA-binding transcription factor activity, RNA polymerase II-specific ISS UniProtKB:Q61473 2290271 BHF-UCL GO_REF:0000024 DNA-binding transcription factor activity, RNA polymerase II-specific ISA tfclass:4.1.1 2290271 NTNU_SB GO_REF:0000113 DNA-binding transcription factor activity, RNA polymerase II-specific ISM InterPro:IPR009071 2290271 (PMID:19274049) NTNU_SB PMID:19274049 DNA-binding transcription factor activity, RNA polymerase II-specific IBA FB:FBgn0000411 more ... 2290271 (PMID:21873635) GO_Central PMID:21873635 protein binding IPI UniProtKB:P35222 2290271 (PMID:17875931) IntAct PMID:17875931 sequence-specific DNA binding IEA UniProtKB:Q61473 , ensembl:ENSMUSP000000270352290271 Ensembl GO_REF:0000107 transcription coactivator activity IEA UniProtKB:Q61473 , ensembl:ENSMUSP000000270352290271 Ensembl GO_REF:0000107 transcription factor binding IPI UniProtKB:Q9NQB0 2290271 (PMID:17875931) BHF-UCL PMID:17875931 transcription factor binding IPI UniProtKB:Q01860-1 2290271 (PMID:19736317) BHF-UCL PMID:19736317 transcription regulatory region DNA binding ISS UniProtKB:P40646 2290271 BHF-UCL GO_REF:0000024 transcription regulatory region DNA binding ISS UniProtKB:Q61473 2290271 BHF-UCL GO_REF:0000024
Gene-Chemical Interaction Annotations
