(S)-nicotine decreases expression ISO RGD:2835 6480464 Nicotine results in decreased expression of HSD11B2 mRNA, Nicotine results in decreased expression of HSD11B2 protein CTD PMID:22265867 (S)-nicotine affects expression ISO RGD:2835 6480464 Nicotine affects the expression of HSD11B2 mRNA CTD PMID:31972234 (S)-nicotine increases expression ISO RGD:2835 6480464 Nicotine results in increased expression of HSD11B2 mRNA, Nicotine results in increased expression of HSD11B2 protein CTD PMID:29486207 (S)-nicotine increases expression EXP 6480464 Nicotine results in increased expression of HSD11B2 mRNA, Nicotine results in increased expression of HSD11B2 protein CTD PMID:29486207 (S)-nicotine multiple interactions EXP 6480464 2-2-chloro-4-iodophenylamino-N-cyclopropylmethoxy-3 more ... CTD PMID:29486207 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane decreases activity ISO RGD:2835 6480464 2 more ... CTD PMID:23333641 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane decreases activity EXP 6480464 2 more ... CTD PMID:23333641 1,1-dichloroethene decreases expression ISO RGD:10735 6480464 vinylidene chloride results in decreased expression of HSD11B2 mRNA CTD PMID:26682919 1,4-dithiothreitol multiple interactions EXP 6480464 Dithiothreitol inhibits the reaction [Thiram results in decreased activity of HSD11B2 protein], Dithiothreitol inhibits the reaction [Ziram results in decreased activity of HSD11B2 protein] CTD PMID:12901862 , PMID:26859423 1,4-dithiothreitol multiple interactions ISO RGD:2835 6480464 Dithiothreitol inhibits the reaction [Ziram results in decreased activity of HSD11B2 protein] CTD PMID:26859423 1,7-dimethylxanthine multiple interactions EXP 6480464 1 more ... CTD PMID:22701600 1,7-dimethylxanthine decreases expression EXP 6480464 1, 7-dimethylxanthine results in decreased expression of HSD11B2 mRNA CTD PMID:22701600 11-dehydrocorticosterone multiple interactions ISO RGD:2835 6480464 [HSD11B2 protein results in increased metabolism of Corticosterone] which results in increased chemical synthesis of 11-dehydrocorticosterone more ... CTD PMID:26859423 , PMID:32243540 17alpha-ethynylestradiol increases expression ISO RGD:2835 6480464 Ethinyl Estradiol results in increased expression of HSD11B2 mRNA CTD PMID:12075121 more ... 17beta-estradiol decreases expression EXP 6480464 Estradiol results in decreased expression of HSD11B2 protein CTD PMID:17515840 17beta-estradiol multiple interactions ISO RGD:10735 6480464 [bisphenol A results in increased susceptibility to Estradiol] which results in decreased expression of HSD11B2 mRNA CTD PMID:27312807 17beta-estradiol multiple interactions ISO RGD:2835 6480464 [bisphenol A co-treated with Estradiol] results in increased expression of HSD11B2 mRNA CTD PMID:26496021 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of HSD11B2 mRNA CTD PMID:23019147 17beta-estradiol multiple interactions EXP 6480464 [Estradiol binds to ESR2 protein] which results in increased expression of HSD11B2 mRNA more ... CTD PMID:20404318 more ... 2,2',4,4',5,5'-hexachlorobiphenyl decreases expression EXP 6480464 2 more ... CTD PMID:23146750 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO RGD:10735 6480464 [2 more ... CTD PMID:25510870 2,2',4,4'-Tetrabromodiphenyl ether decreases expression EXP 6480464 2 more ... CTD PMID:23146750 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO RGD:10735 6480464 [2 more ... CTD PMID:25510870 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:2835 6480464 Tetrachlorodibenzodioxin affects the expression of HSD11B2 mRNA CTD PMID:22298810 2,4,6-trinitrotoluene affects expression ISO RGD:2835 6480464 Trinitrotoluene affects the expression of HSD11B2 mRNA CTD PMID:21346803 2,4-dinitrotoluene affects expression ISO RGD:2835 6480464 2, 4-dinitrotoluene affects the expression of HSD11B2 mRNA CTD PMID:21346803 3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine decreases activity ISO RGD:2835 6480464 Puromycin Aminonucleoside results in decreased activity of HSD11B2 protein CTD PMID:11981059 3,3',4,4',5-pentachlorobiphenyl decreases expression EXP 6480464 3 more ... CTD PMID:23146750 4,4'-sulfonyldiphenol increases expression ISO RGD:10735 6480464 bis4-hydroxyphenylsulfone results in increased expression of HSD11B2 mRNA CTD PMID:30951980 4,4'-sulfonyldiphenol increases expression EXP 6480464 bis4-hydroxyphenylsulfone results in increased expression of HSD11B2 mRNA, bis4-hydroxyphenylsulfone results in increased expression of HSD11B2 protein CTD PMID:30352284 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one multiple interactions EXP 6480464 [Benzoapyrene co-treated with 4-N-methyl-N-nitrosamino-1-3-pyridyl-1-butanone] results in increased expression of HSD11B2 mRNA, Grape Seed Proanthocyanidins inhibits the reaction [[Benzoapyrene co-treated with 4-N-methyl-N-nitrosamino-1-3-pyridyl-1-butanone] results in increased expression of HSD11B2 mRNA] CTD PMID:20146248 4-nonylphenol decreases activity EXP 6480464 4-nonylphenol results in decreased activity of HSD11B2 protein CTD PMID:16184081 4-octylphenol decreases activity EXP 6480464 4-octylphenol results in decreased activity of HSD11B2 protein CTD PMID:16184081 5-aza-2'-deoxycytidine increases expression ISO RGD:2835 6480464 Decitabine results in increased expression of HSD11B2 mRNA CTD PMID:15489962 5-aza-2'-deoxycytidine increases expression EXP 6480464 Decitabine results in increased expression of HSD11B2 mRNA CTD PMID:15489962 6-propyl-2-thiouracil increases expression ISO RGD:2835 6480464 Propylthiouracil results in increased expression of HSD11B2 mRNA CTD PMID:24780913 8-Br-cAMP decreases expression EXP 6480464 8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of HSD11B2 mRNA CTD PMID:22079614 8-Br-cAMP multiple interactions EXP 6480464 [Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of HSD11B2 protein CTD PMID:23275455 actinomycin D multiple interactions EXP 6480464 Dactinomycin inhibits the reaction [Bexarotene results in increased expression of HSD11B2 mRNA] more ... CTD PMID:31927052 aflatoxin B1 decreases expression ISO RGD:2835 6480464 Aflatoxin B1 results in decreased expression of HSD11B2 mRNA CTD PMID:23630614 aldehydo-D-glucose decreases expression ISO RGD:2835 6480464 Glucose results in decreased expression of HSD11B2 mRNA CTD PMID:15017115 ammonium chloride affects expression ISO RGD:2835 6480464 Ammonium Chloride affects the expression of HSD11B2 mRNA CTD PMID:16483693 arsenic acid increases expression ISO RGD:10735 6480464 arsenic acid results in increased expression of HSD11B2 mRNA CTD PMID:26855884 atrazine increases expression EXP 6480464 Atrazine results in increased expression of HSD11B2 mRNA CTD PMID:18461179 atrazine multiple interactions EXP 6480464 NR5A1 protein promotes the reaction [Atrazine results in increased expression of HSD11B2 mRNA], SGK1 protein affects the reaction [Atrazine results in increased expression of HSD11B2 mRNA] CTD PMID:18461179 azathioprine decreases expression EXP 6480464 Azathioprine results in decreased expression of HSD11B2 mRNA CTD PMID:22623647 baicalein multiple interactions EXP 6480464 12-Hydroxy-5 more ... CTD PMID:18032417 baicalein increases activity EXP 6480464 baicalein results in increased activity of HSD11B2 protein CTD PMID:18032417 beclomethasone increases metabolic processing EXP 6480464 HSD11B2 protein results in increased metabolism of Beclomethasone CTD PMID:16549198 benzo[a]pyrene increases expression EXP 6480464 Benzoapyrene results in increased expression of HSD11B2 mRNA CTD PMID:24361490 benzo[a]pyrene decreases expression EXP 6480464 Benzoapyrene results in decreased expression of HSD11B2 mRNA CTD PMID:26238291 benzo[a]pyrene multiple interactions EXP 6480464 [Benzoapyrene co-treated with 4-N-methyl-N-nitrosamino-1-3-pyridyl-1-butanone] results in increased expression of HSD11B2 mRNA, Grape Seed Proanthocyanidins inhibits the reaction [[Benzoapyrene co-treated with 4-N-methyl-N-nitrosamino-1-3-pyridyl-1-butanone] results in increased expression of HSD11B2 mRNA] CTD PMID:20146248 betamethasone multiple interactions ISO RGD:2835 6480464 Betamethasone inhibits the reaction [HSD11B2 protein affects the metabolism of Corticosterone] CTD PMID:19490994 betamethasone increases metabolic processing EXP 6480464 HSD11B2 protein results in increased metabolism of Betamethasone CTD PMID:16549198 bexarotene increases expression EXP 6480464 Bexarotene results in increased expression of HSD11B2 mRNA CTD PMID:31927052 bexarotene multiple interactions EXP 6480464 Bexarotene results in increased expression of and results in increased activity of HSD11B2 protein more ... CTD PMID:31927052 bis(2-ethylhexyl) phthalate decreases expression ISO RGD:2835 6480464 Diethylhexyl Phthalate results in decreased expression of HSD11B2 mRNA CTD PMID:19560483 bisphenol A decreases activity ISO RGD:2835 6480464 bisphenol A results in decreased activity of HSD11B2 protein CTD PMID:23069880 bisphenol A increases expression ISO RGD:10735 6480464 bisphenol A results in increased expression of HSD11B2 mRNA CTD PMID:30951980 bisphenol A increases methylation ISO RGD:10735 6480464 bisphenol A results in increased methylation of HSD11B2 promoter CTD PMID:27312807 bisphenol A multiple interactions ISO RGD:10735 6480464 [bisphenol A results in increased susceptibility to Estradiol] which results in decreased expression of HSD11B2 mRNA CTD PMID:27312807 bisphenol A increases expression ISO RGD:2835 6480464 bisphenol A results in increased expression of HSD11B2 mRNA CTD PMID:12075121 , PMID:25181051 bisphenol A multiple interactions ISO RGD:2835 6480464 [bisphenol A co-treated with Estradiol] results in increased expression of HSD11B2 mRNA CTD PMID:26496021 bisphenol A decreases expression ISO RGD:10735 6480464 bisphenol A results in decreased expression of HSD11B2 mRNA CTD PMID:26063408 bisphenol A multiple interactions EXP 6480464 bisphenol A results in increased expression of and results in increased activity of HSD11B2 protein CTD PMID:25784278 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of HSD11B2 mRNA, bisphenol A results in increased expression of HSD11B2 protein CTD PMID:25784278 , PMID:30352284 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of HSD11B2 mRNA CTD PMID:23146750 bisphenol A decreases activity EXP 6480464 bisphenol A results in decreased activity of HSD11B2 protein CTD PMID:23069880 bisphenol F increases expression ISO RGD:10735 6480464 bisphenol F results in increased expression of HSD11B2 mRNA CTD PMID:30951980 bromobenzene decreases expression ISO RGD:2835 6480464 bromobenzene results in decreased expression of HSD11B2 mRNA CTD PMID:32479839 C60 fullerene decreases expression ISO RGD:2835 6480464 fullerene C60 results in decreased expression of HSD11B2 mRNA CTD PMID:19167457 cadmium atom increases activity EXP 6480464 Cadmium results in increased activity of HSD11B2 protein CTD PMID:20624455 cadmium atom multiple interactions EXP 6480464 Cadmium results in decreased expression of and results in decreased activity of HSD11B2 protein more ... CTD PMID:16144812 , PMID:23966319 cadmium atom decreases activity EXP 6480464 Cadmium results in decreased activity of HSD11B2 protein CTD PMID:22796344 , PMID:23880315 cadmium atom decreases expression EXP 6480464 Cadmium results in decreased expression of HSD11B2 mRNA CTD PMID:16144812 , PMID:23966319 cadmium atom increases expression EXP 6480464 Cadmium results in increased expression of HSD11B2 mRNA CTD PMID:20624455 cadmium atom decreases methylation EXP 6480464 Cadmium results in decreased methylation of HSD11B2 promoter CTD PMID:20624455 caffeine decreases expression ISO RGD:2835 6480464 Caffeine results in decreased expression of HSD11B2 mRNA CTD PMID:22583948 more ... caffeine multiple interactions EXP 6480464 ADORA2B mutant form inhibits the reaction [Caffeine results in decreased expression of and results in decreased activity of HSD11B2 protein] more ... CTD PMID:22701600 caffeine decreases expression EXP 6480464 Caffeine results in decreased expression of HSD11B2 mRNA CTD PMID:22701600 calcitriol increases expression EXP 6480464 Calcitriol results in increased expression of HSD11B2 mRNA CTD PMID:21592394 calcitriol multiple interactions EXP 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of HSD11B2 mRNA CTD PMID:21592394 CARBENOXOLONE decreases activity ISO RGD:10735 6480464 Carbenoxolone results in decreased activity of HSD11B2 protein CTD PMID:24135201 CARBENOXOLONE decreases activity ISO RGD:2835 6480464 Carbenoxolone results in decreased activity of HSD11B2 protein CTD PMID:23814014 CARBENOXOLONE decreases activity EXP 6480464 Carbenoxolone results in decreased activity of HSD11B2 protein CTD PMID:16857225 , PMID:24135201 chloroprene decreases expression ISO RGD:2835 6480464 Chloroprene results in decreased expression of HSD11B2 mRNA CTD PMID:23125180 colforsin daropate hydrochloride multiple interactions EXP 6480464 Colforsin inhibits the reaction [1 more ... CTD PMID:22701600 , PMID:29802914 colforsin daropate hydrochloride increases expression EXP 6480464 Colforsin results in increased expression of HSD11B2 mRNA, Colforsin results in increased expression of HSD11B2 protein CTD PMID:24361490 , PMID:29802914 copper atom decreases expression ISO RGD:2835 6480464 Copper results in decreased expression of HSD11B2 mRNA CTD PMID:30556269 copper(0) decreases expression ISO RGD:2835 6480464 Copper results in decreased expression of HSD11B2 mRNA CTD PMID:30556269 copper(II) sulfate decreases expression EXP 6480464 Copper Sulfate results in decreased expression of HSD11B2 mRNA CTD PMID:19549813 corticosterone multiple interactions ISO RGD:2835 6480464 [HSD11B2 protein results in increased metabolism of Corticosterone] which results in increased chemical synthesis of 11-dehydrocorticosterone more ... CTD PMID:19490994 more ... corticosterone increases oxidation ISO RGD:2835 6480464 HSD11B2 protein results in increased oxidation of Corticosterone CTD PMID:26859423 corticosterone increases metabolic processing ISO RGD:10735 6480464 HSD11B2 protein results in increased metabolism of Corticosterone CTD PMID:22796344 corticosterone affects metabolic processing ISO RGD:2835 6480464 HSD11B2 protein affects the metabolism of Corticosterone CTD PMID:19490994 cortisol affects binding EXP 6480464 HSD11B2 protein binds to Hydrocortisone CTD PMID:22273746 cortisol decreases expression EXP 6480464 Hydrocortisone results in decreased expression of HSD11B2 mRNA, Hydrocortisone results in decreased expression of HSD11B2 protein CTD PMID:30528684 cortisol increases oxidation EXP 6480464 HSD11B2 protein results in increased oxidation of Hydrocortisone CTD PMID:26859423 cortisol multiple interactions EXP 6480464 [HSD11B2 protein results in increased oxidation of Hydrocortisone] which results in increased chemical synthesis of Cortisone more ... CTD PMID:26859423 , PMID:30528684 cortisol increases metabolic processing EXP 6480464 HSD11B2 protein results in increased metabolism of Hydrocortisone CTD PMID:22796344 cortisone increases chemical synthesis EXP 6480464 HSD11B2 protein results in increased chemical synthesis of Cortisone CTD PMID:22796344 cortisone multiple interactions EXP 6480464 [HSD11B2 protein results in increased oxidation of Hydrocortisone] which results in increased chemical synthesis of Cortisone, Ziram inhibits the reaction [[HSD11B2 protein results in increased oxidation of Hydrocortisone] which results in increased chemical synthesis of Cortisone] CTD PMID:26859423 cosyntropin decreases expression EXP 6480464 Cosyntropin results in decreased expression of HSD11B2 protein CTD PMID:11082157 cycloheximide multiple interactions EXP 6480464 Cycloheximide promotes the reaction [Bexarotene results in increased expression of HSD11B2 mRNA] more ... CTD PMID:31927052 cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of HSD11B2 mRNA CTD PMID:25562108 D-glucose decreases expression ISO RGD:2835 6480464 Glucose results in decreased expression of HSD11B2 mRNA CTD PMID:15017115 danazol decreases activity EXP 6480464 Danazol results in decreased activity of HSD11B2 protein CTD PMID:22273746 danazol multiple interactions EXP 6480464 Danazol inhibits the reaction [HSD11B2 protein results in decreased activity of Glucocorticoids] CTD PMID:22273746 dexamethasone increases expression EXP 6480464 Dexamethasone results in increased expression of HSD11B2 mRNA, Dexamethasone results in increased expression of HSD11B2 protein CTD PMID:15679045 dexamethasone increases expression ISO RGD:10735 6480464 Dexamethasone results in increased expression of HSD11B2 mRNA CTD PMID:29624291 dexamethasone increases metabolic processing EXP 6480464 HSD11B2 protein results in increased metabolism of Dexamethasone CTD PMID:16549198 dexamethasone multiple interactions ISO RGD:2835 6480464 Dexamethasone inhibits the reaction [HSD11B2 protein affects the metabolism of Corticosterone] CTD PMID:19490994 dexamethasone increases expression ISO RGD:2835 6480464 Dexamethasone results in increased expression of HSD11B2 mRNA CTD PMID:19490994 dexamethasone multiple interactions EXP 6480464 Thiram inhibits the reaction [HSD11B2 protein results in increased oxidation of Dexamethasone] CTD PMID:16857225 dexamethasone increases oxidation EXP 6480464 HSD11B2 protein results in increased oxidation of Dexamethasone CTD PMID:16857225 dextran sulfate multiple interactions ISO RGD:10735 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of HSD11B2 mRNA CTD PMID:29950665 dibutyl phthalate decreases activity EXP 6480464 Dibutyl Phthalate results in decreased activity of HSD11B2 protein CTD PMID:19786001 dibutyl phthalate decreases expression ISO RGD:10735 6480464 Dibutyl Phthalate results in decreased expression of HSD11B2 mRNA CTD PMID:17361019 , PMID:21266533 dibutyl phthalate decreases expression ISO RGD:2835 6480464 Dibutyl Phthalate results in decreased expression of HSD11B2 mRNA CTD PMID:19560483 , PMID:21266533 dibutyl phthalate decreases activity ISO RGD:2835 6480464 Dibutyl Phthalate results in decreased activity of HSD11B2 protein CTD PMID:19786001 dibutylstannane decreases activity EXP 6480464 di-n-butyltin results in decreased activity of HSD11B2 protein CTD PMID:22796344 dicrotophos increases expression EXP 6480464 dicrotophos results in increased expression of HSD11B2 mRNA CTD PMID:28302478 Dicyclohexyl phthalate decreases activity ISO RGD:2835 6480464 dicyclohexyl phthalate results in decreased activity of HSD11B2 protein CTD PMID:19786001 Dicyclohexyl phthalate decreases activity EXP 6480464 dicyclohexyl phthalate results in decreased activity of HSD11B2 protein CTD PMID:16184081 diethyldithiocarbamic acid decreases activity EXP 6480464 Ditiocarb results in decreased activity of HSD11B2 protein CTD PMID:22796344 diethylstilbestrol increases expression ISO RGD:2835 6480464 Diethylstilbestrol results in increased expression of HSD11B2 mRNA CTD PMID:21658437 dipentyl phthalate decreases expression ISO RGD:2835 6480464 di-n-pentyl phthalate results in decreased expression of HSD11B2 mRNA CTD PMID:19560483 diphenylstannane decreases activity EXP 6480464 diphenyltin results in decreased activity of HSD11B2 protein CTD PMID:22796344 dipropyl phthalate decreases activity EXP 6480464 di-n-propylphthalate results in decreased activity of HSD11B2 protein CTD PMID:19786001 dipropyl phthalate decreases activity ISO RGD:2835 6480464 di-n-propylphthalate results in decreased activity of HSD11B2 protein CTD PMID:19786001 disulfiram decreases activity EXP 6480464 Disulfiram results in decreased activity of HSD11B2 protein CTD PMID:22796344 docebenone increases activity EXP 6480464 2 more ... CTD PMID:18032417 docebenone multiple interactions EXP 6480464 [2 more ... CTD PMID:18032417 dorsomorphin multiple interactions EXP 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-5-benzo1 more ... CTD PMID:27188386 doxorubicin decreases activity ISO RGD:2835 6480464 Doxorubicin results in decreased activity of HSD11B2 protein CTD PMID:11981059 elemental selenium multiple interactions ISO RGD:2835 6480464 [Selenium deficiency co-treated with Vitamin E deficiency] results in decreased expression of HSD11B2 mRNA CTD PMID:11444866 endosulfan decreases expression ISO RGD:2835 6480464 Endosulfan results in decreased expression of HSD11B2 mRNA CTD PMID:29391264 entinostat multiple interactions EXP 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in increased expression of HSD11B2 mRNA CTD PMID:27188386 entinostat increases expression EXP 6480464 entinostat results in increased expression of HSD11B2 mRNA CTD PMID:26272509 , PMID:27188386 ethanol increases expression ISO RGD:2835 6480464 Ethanol results in increased expression of HSD11B2 mRNA CTD PMID:32437893 ethanol multiple interactions ISO RGD:2835 6480464 Ethanol affects the reaction [Dietary Fats affects the expression of HSD11B2 mRNA] CTD PMID:31811911 ethanol multiple interactions EXP 6480464 Colforsin inhibits the reaction [Ethanol results in decreased expression of HSD11B2 mRNA] more ... CTD PMID:29802914 ethanol decreases expression EXP 6480464 Ethanol results in decreased expression of HSD11B2 mRNA, Ethanol results in decreased expression of HSD11B2 protein CTD PMID:29802914 ethanol decreases expression ISO RGD:2835 6480464 Ethanol results in decreased expression of HSD11B2 mRNA, Ethanol results in decreased expression of HSD11B2 protein CTD PMID:29802914 ethanol affects expression ISO RGD:2835 6480464 Ethanol affects the expression of HSD11B2 mRNA CTD PMID:31039417 , PMID:32535229 fentin chloride multiple interactions EXP 6480464 4-4-fluorophenyl-2-4-hydroxyphenyl-5-4-pyridylimidazole inhibits the reaction [triphenyltin chloride results in increased activity of HSD11B2 protein] more ... CTD PMID:31927052 fentin chloride increases expression EXP 6480464 triphenyltin chloride results in increased expression of HSD11B2 mRNA CTD PMID:31927052 fludioxonil increases activity EXP 6480464 fludioxonil results in increased activity of HSD11B2 protein CTD PMID:31927052 fluoxymesterone multiple interactions EXP 6480464 Fluoxymesterone inhibits the reaction [HSD11B2 protein results in decreased activity of Glucocorticoids], HSD11B2 protein binds to and results in increased metabolism of Fluoxymesterone CTD PMID:22273746 fluoxymesterone decreases activity EXP 6480464 Fluoxymesterone results in decreased activity of HSD11B2 protein CTD PMID:22273746 flurbiprofen increases expression ISO RGD:10735 6480464 Flurbiprofen results in increased expression of HSD11B2 mRNA CTD PMID:16949054 genistein increases expression ISO RGD:2835 6480464 Genistein results in increased expression of HSD11B2 mRNA CTD PMID:12075121 genistein increases expression EXP 6480464 Genistein results in increased expression of HSD11B2 mRNA CTD PMID:23019147 gentamycin decreases expression ISO RGD:2835 6480464 Gentamicins results in decreased expression of HSD11B2 mRNA CTD PMID:22061828 glucose decreases expression ISO RGD:2835 6480464 Glucose results in decreased expression of HSD11B2 mRNA CTD PMID:15017115 glycyrrhetinate decreases activity EXP 6480464 18alpha-glycyrrhetinic acid results in decreased activity of HSD11B2 protein CTD PMID:24135201 glycyrrhetinate multiple interactions EXP 6480464 Glycyrrhetinic Acid inhibits the reaction [tributyltin results in increased activity of HSD11B2 protein], Glycyrrhetinic Acid inhibits the reaction [triphenyltin chloride results in increased activity of HSD11B2 protein] CTD PMID:31927052 glycyrrhetinate decreases activity ISO RGD:10735 6480464 18alpha-glycyrrhetinic acid results in decreased activity of HSD11B2 protein CTD PMID:24135201 glycyrrhetinic acid decreases activity EXP 6480464 18alpha-glycyrrhetinic acid results in decreased activity of HSD11B2 protein CTD PMID:24135201 glycyrrhetinic acid multiple interactions EXP 6480464 Glycyrrhetinic Acid inhibits the reaction [tributyltin results in increased activity of HSD11B2 protein], Glycyrrhetinic Acid inhibits the reaction [triphenyltin chloride results in increased activity of HSD11B2 protein] CTD PMID:31927052 glycyrrhetinic acid decreases activity ISO RGD:10735 6480464 18alpha-glycyrrhetinic acid results in decreased activity of HSD11B2 protein CTD PMID:24135201 glycyrrhizinic acid decreases expression ISO RGD:2835 6480464 Glycyrrhizic Acid results in decreased expression of HSD11B2 mRNA CTD PMID:10474021 , PMID:11798659 hydrogen peroxide affects expression EXP 6480464 Hydrogen Peroxide affects the expression of HSD11B2 mRNA CTD PMID:23410634 indometacin decreases activity EXP 6480464 Indomethacin results in decreased activity of HSD11B2 protein CTD PMID:10377029 ketoconazole decreases activity EXP 6480464 Ketoconazole results in decreased activity of HSD11B2 protein CTD PMID:10664531 L-1,4-dithiothreitol multiple interactions EXP 6480464 Dithiothreitol inhibits the reaction [Thiram results in decreased activity of HSD11B2 protein], Dithiothreitol inhibits the reaction [Ziram results in decreased activity of HSD11B2 protein] CTD PMID:12901862 , PMID:26859423 L-1,4-dithiothreitol multiple interactions ISO RGD:2835 6480464 Dithiothreitol inhibits the reaction [Ziram results in decreased activity of HSD11B2 protein] CTD PMID:26859423 leflunomide decreases expression ISO RGD:2835 6480464 leflunomide results in decreased expression of HSD11B2 mRNA CTD PMID:24136188 leukotriene B4 multiple interactions EXP 6480464 [2 more ... CTD PMID:18032417 leukotriene B4 decreases expression EXP 6480464 Leukotriene B4 results in decreased expression of HSD11B2 mRNA CTD PMID:18032417 leukotriene B4 decreases activity EXP 6480464 Leukotriene B4 results in decreased activity of HSD11B2 protein CTD PMID:10377029 , PMID:18032417 lithium atom increases expression ISO RGD:2835 6480464 Lithium results in increased expression of HSD11B2 mRNA, Lithium results in increased expression of HSD11B2 protein CTD PMID:15687245 lithium hydride increases expression ISO RGD:2835 6480464 Lithium results in increased expression of HSD11B2 mRNA, Lithium results in increased expression of HSD11B2 protein CTD PMID:15687245 maneb decreases activity EXP 6480464 Maneb results in decreased activity of HSD11B2 protein CTD PMID:22796344 masoprocol multiple interactions EXP 6480464 12-Hydroxy-5 more ... CTD PMID:18032417 masoprocol increases expression EXP 6480464 Masoprocol results in increased expression of HSD11B2 mRNA CTD PMID:18032417 masoprocol increases activity EXP 6480464 Masoprocol results in increased activity of HSD11B2 protein CTD PMID:10377029 , PMID:18032417 medroxyprogesterone acetate multiple interactions EXP 6480464 [Medroxyprogesterone Acetate co-treated with 8-Bromo Cyclic Adenosine Monophosphate] results in increased expression of HSD11B2 protein CTD PMID:23275455 menadione affects expression EXP 6480464 Vitamin K 3 affects the expression of HSD11B2 mRNA CTD PMID:23410634 mercury dichloride decreases expression ISO RGD:2835 6480464 Mercuric Chloride results in decreased expression of HSD11B2 protein CTD PMID:16189294 metyrapone decreases activity EXP 6480464 Metyrapone results in decreased activity of HSD11B2 protein CTD PMID:10664531 mifepristone multiple interactions EXP 6480464 Masoprocol promotes the reaction [Mifepristone results in increased activity of HSD11B2 protein] more ... CTD PMID:18032417 , PMID:30528684 mifepristone increases expression EXP 6480464 Mifepristone results in increased expression of HSD11B2 mRNA, Mifepristone results in increased expression of HSD11B2 protein CTD PMID:18032417 mono(2-ethylhexyl) phthalate decreases activity EXP 6480464 mono-2-ethylhexylphthalate results in decreased activity of HSD11B2 protein CTD PMID:19786001 mono(2-ethylhexyl) phthalate affects expression ISO RGD:10735 6480464 mono-2-ethylhexylphthalate affects the expression of HSD11B2 mRNA CTD PMID:21195148 mono(2-ethylhexyl) phthalate decreases activity ISO RGD:2835 6480464 mono-2-ethylhexylphthalate results in decreased activity of HSD11B2 protein CTD PMID:19786001 Monobutylphthalate affects expression ISO RGD:10735 6480464 monobutyl phthalate affects the expression of HSD11B2 mRNA CTD PMID:21195148 N-acetyl-L-cysteine multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of HSD11B2 mRNA] CTD PMID:18829485 N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal multiple interactions EXP 6480464 benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Progesterone results in increased expression of HSD11B2 mRNA] CTD PMID:15857753 N-ethylmaleimide multiple interactions EXP 6480464 Ethylmaleimide promotes the reaction [Thiram results in decreased activity of HSD11B2 protein] CTD PMID:22796344 N-Nitrosopyrrolidine increases expression EXP 6480464 N-Nitrosopyrrolidine results in increased expression of HSD11B2 mRNA CTD PMID:32234424 NAD zwitterion increases reduction ISO RGD:2835 6480464 HSD11B2 protein results in increased reduction of NAD CTD PMID:26859423 NAD zwitterion increases reduction EXP 6480464 HSD11B2 protein results in increased reduction of NAD CTD PMID:26859423 NAD zwitterion multiple interactions ISO RGD:2835 6480464 Ziram inhibits the reaction [HSD11B2 protein results in increased reduction of NAD] CTD PMID:26859423 NAD zwitterion multiple interactions EXP 6480464 Ziram inhibits the reaction [HSD11B2 protein results in increased reduction of NAD] CTD PMID:26859423 NAD(+) increases reduction EXP 6480464 HSD11B2 protein results in increased reduction of NAD CTD PMID:26859423 NAD(+) increases reduction ISO RGD:2835 6480464 HSD11B2 protein results in increased reduction of NAD CTD PMID:26859423 NAD(+) multiple interactions EXP 6480464 Ziram inhibits the reaction [HSD11B2 protein results in increased reduction of NAD] CTD PMID:26859423 NAD(+) multiple interactions ISO RGD:2835 6480464 Ziram inhibits the reaction [HSD11B2 protein results in increased reduction of NAD] CTD PMID:26859423 NADP zwitterion multiple interactions EXP 6480464 NADP binds to and results in increased activity of HSD11B2 protein CTD PMID:25526675 NADP(+) multiple interactions EXP 6480464 NADP binds to and results in increased activity of HSD11B2 protein CTD PMID:25526675 nickel atom decreases expression EXP 6480464 Nickel results in decreased expression of HSD11B2 mRNA CTD PMID:24768652 , PMID:25583101 nicotine decreases expression ISO RGD:2835 6480464 Nicotine results in decreased expression of HSD11B2 mRNA, Nicotine results in decreased expression of HSD11B2 protein CTD PMID:22265867 nicotine affects expression ISO RGD:2835 6480464 Nicotine affects the expression of HSD11B2 mRNA CTD PMID:31972234 nicotine increases expression EXP 6480464 Nicotine results in increased expression of HSD11B2 mRNA, Nicotine results in increased expression of HSD11B2 protein CTD PMID:29486207 nicotine increases expression ISO RGD:2835 6480464 Nicotine results in increased expression of HSD11B2 mRNA, Nicotine results in increased expression of HSD11B2 protein CTD PMID:29486207 nicotine multiple interactions EXP 6480464 2-2-chloro-4-iodophenylamino-N-cyclopropylmethoxy-3 more ... CTD PMID:29486207 oxymetholone multiple interactions EXP 6480464 Oxymetholone inhibits the reaction [HSD11B2 protein results in decreased activity of Glucocorticoids] CTD PMID:22273746 oxymetholone decreases activity EXP 6480464 Oxymetholone results in decreased activity of HSD11B2 protein CTD PMID:22273746 paracetamol decreases expression ISO RGD:10735 6480464 Acetaminophen results in decreased expression of HSD11B2 mRNA CTD PMID:17585979 paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of HSD11B2 mRNA CTD PMID:29067470 paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of HSD11B2 mRNA CTD PMID:26690555 paracetamol affects expression ISO RGD:10735 6480464 Acetaminophen affects the expression of HSD11B2 mRNA CTD PMID:17562736 PCB138 multiple interactions ISO RGD:10735 6480464 [2 more ... CTD PMID:25510870 perfluorooctanoic acid decreases expression EXP 6480464 perfluorooctanoic acid results in decreased expression of HSD11B2 mRNA CTD PMID:23146750 prednisolone increases metabolic processing EXP 6480464 HSD11B2 protein results in increased metabolism of Prednisolone CTD PMID:16549198 procainamide increases expression EXP 6480464 Procainamide results in increased expression of HSD11B2 mRNA CTD PMID:15489962 procainamide increases expression ISO RGD:2835 6480464 Procainamide results in increased expression of HSD11B2 mRNA CTD PMID:15489962 progesterone multiple interactions EXP 6480464 [Estradiol co-treated with Progesterone] results in increased expression of HSD11B2 mRNA more ... CTD PMID:15857753 more ... progesterone decreases expression EXP 6480464 Progesterone results in decreased expression of HSD11B2 mRNA, Progesterone results in decreased expression of HSD11B2 protein CTD PMID:18032417 more ... progesterone increases expression EXP 6480464 Progesterone results in increased expression of HSD11B2 mRNA CTD PMID:15857753 progesterone decreases activity EXP 6480464 Progesterone results in decreased activity of HSD11B2 protein CTD PMID:18032417 prostaglandin E2 decreases activity EXP 6480464 Dinoprostone results in decreased activity of HSD11B2 protein CTD PMID:10377029 prostaglandin F2alpha decreases activity EXP 6480464 Dinoprost results in decreased activity of HSD11B2 protein CTD PMID:10377029 prostaglandin F2alpha decreases expression ISO RGD:2835 6480464 Dinoprost results in decreased expression of HSD11B2 mRNA CTD PMID:11517196 pyrrolidine dithiocarbamate decreases activity EXP 6480464 pyrrolidine dithiocarbamic acid results in decreased activity of HSD11B2 protein CTD PMID:22796344 quercetin decreases expression ISO RGD:2835 6480464 Quercetin results in decreased expression of HSD11B2 protein CTD PMID:18095365 SB 431542 multiple interactions EXP 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-5-benzo1 more ... CTD PMID:27188386 selenium atom multiple interactions ISO RGD:2835 6480464 [Selenium deficiency co-treated with Vitamin E deficiency] results in decreased expression of HSD11B2 mRNA CTD PMID:11444866 silicon dioxide decreases expression EXP 6480464 Silicon Dioxide results in decreased expression of HSD11B2 mRNA CTD PMID:25351596 silicon dioxide increases expression ISO RGD:10735 6480464 Silicon Dioxide results in increased expression of HSD11B2 mRNA CTD PMID:29341224 sodium arsenate decreases expression EXP 6480464 sodium arsenate results in decreased expression of HSD11B2 mRNA CTD PMID:12727804 sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of HSD11B2 mRNA CTD PMID:12727804 sodium chloride decreases activity ISO RGD:2835 6480464 Sodium Chloride results in decreased activity of HSD11B2 protein CTD PMID:12943734 sodium chloride decreases expression ISO RGD:2835 6480464 Sodium Chloride results in decreased expression of HSD11B2 mRNA CTD PMID:12943734 spironolactone decreases expression ISO RGD:2835 6480464 Spironolactone results in decreased expression of HSD11B2 mRNA CTD PMID:17587755 tert-butyl hydroperoxide affects expression EXP 6480464 tert-Butylhydroperoxide affects the expression of HSD11B2 mRNA CTD PMID:23410634 testosterone multiple interactions EXP 6480464 [Testosterone co-treated with Calcitriol] results in increased expression of HSD11B2 mRNA, Testosterone inhibits the reaction [HSD11B2 protein results in decreased activity of Glucocorticoids] CTD PMID:21592394 , PMID:22273746 testosterone decreases activity EXP 6480464 Testosterone results in decreased activity of HSD11B2 protein CTD PMID:22273746 testosterone increases expression EXP 6480464 Testosterone results in increased expression of HSD11B2 mRNA CTD PMID:21592394 tetrachloromethane decreases expression ISO RGD:2835 6480464 Carbon Tetrachloride results in decreased expression of HSD11B2 mRNA, Carbon Tetrachloride results in decreased expression of HSD11B2 protein CTD PMID:16192424 , PMID:31150632 thalidomide decreases expression ISO RGD:10735 6480464 Thalidomide results in decreased expression of HSD11B2 mRNA CTD PMID:26217789 thiram multiple interactions EXP 6480464 Dithiothreitol inhibits the reaction [Thiram results in decreased activity of HSD11B2 protein] more ... CTD PMID:12901862 more ... thiram decreases activity EXP 6480464 Thiram results in decreased activity of HSD11B2 protein CTD PMID:12901862 more ... titanium dioxide multiple interactions ISO RGD:10735 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of HSD11B2 mRNA CTD PMID:29950665 tributylstannane decreases activity EXP 6480464 tributyltin results in decreased activity of HSD11B2 protein CTD PMID:16184081 , PMID:22796344 tributylstannane increases expression EXP 6480464 tributyltin results in increased expression of HSD11B2 mRNA CTD PMID:31927052 tributylstannane multiple interactions EXP 6480464 Cycloheximide promotes the reaction [tributyltin results in increased expression of HSD11B2 mRNA] more ... CTD PMID:31927052 trichloroethene increases methylation ISO RGD:2835 6480464 Trichloroethylene results in increased methylation of HSD11B2 gene CTD PMID:27618143 trichostatin A increases expression EXP 6480464 trichostatin A results in increased expression of HSD11B2 mRNA CTD PMID:24935251 triphenyl phosphate multiple interactions ISO RGD:2835 6480464 [triphenyl phosphate co-treated with Flame Retardants] results in decreased expression of HSD11B2 mRNA CTD PMID:32243540 triphenylstannane decreases activity EXP 6480464 triphenyltin results in decreased activity of HSD11B2 protein CTD PMID:16184081 , PMID:22796344 triphenylstannane increases expression ISO RGD:2835 6480464 triphenyltin results in increased expression of HSD11B2 mRNA, triphenyltin results in increased expression of HSD11B2 protein CTD PMID:31765896 urethane decreases expression EXP 6480464 Urethane results in decreased expression of HSD11B2 mRNA CTD PMID:28818685 valproic acid increases expression EXP 6480464 Valproic Acid results in increased expression of HSD11B2 mRNA CTD PMID:23179753 , PMID:26272509 valproic acid multiple interactions EXP 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in increased expression of HSD11B2 mRNA CTD PMID:27188386 vecuronium bromide increases expression EXP 6480464 Vecuronium Bromide results in increased expression of HSD11B2 mRNA, Vecuronium Bromide results in increased expression of HSD11B2 protein CTD PMID:29486207 vecuronium bromide multiple interactions EXP 6480464 Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 mRNA], Vecuronium Bromide inhibits the reaction [Nicotine results in decreased expression of HSD11B2 protein] CTD PMID:29486207 vitamin E multiple interactions ISO RGD:2835 6480464 [Selenium deficiency co-treated with Vitamin E deficiency] results in decreased expression of HSD11B2 mRNA CTD PMID:11444866 zileuton increases activity EXP 6480464 zileuton results in increased activity of HSD11B2 protein CTD PMID:10377029 zinc atom decreases expression ISO RGD:2835 6480464 Zinc deficiency results in decreased expression of HSD11B2 mRNA CTD PMID:15671213 zinc(0) decreases expression ISO RGD:2835 6480464 Zinc deficiency results in decreased expression of HSD11B2 mRNA CTD PMID:15671213 zineb decreases activity EXP 6480464 Zineb results in decreased activity of HSD11B2 protein CTD PMID:22796344 ziram multiple interactions EXP 6480464 Dithiothreitol inhibits the reaction [Ziram results in decreased activity of HSD11B2 protein] more ... CTD PMID:26859423 ziram multiple interactions ISO RGD:2835 6480464 Dithiothreitol inhibits the reaction [Ziram results in decreased activity of HSD11B2 protein] more ... CTD PMID:26859423 ziram decreases activity EXP 6480464 Ziram results in decreased activity of HSD11B2 protein CTD PMID:26859423 ziram decreases activity ISO RGD:2835 6480464 Ziram results in decreased activity of HSD11B2 protein CTD PMID:26859423 zoledronic acid decreases expression EXP 6480464 zoledronic acid results in decreased expression of HSD11B2 mRNA CTD PMID:24714768
