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Gene: DDIT3 (DNA damage inducible transcript 3) Homo sapiens
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Symbol: DDIT3
Name: DNA damage inducible transcript 3
Description: Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; cAMP response element binding protein binding activity; and protein dimerization activity. Predicted to contribute to sequence-specific DNA binding activity. Involved in several processes, including cell redox homeostasis; regulation of gene expression; and regulation of intracellular signal transduction. Localizes to several cellular components, including CHOP-ATF3 complex; CHOP-ATF4 complex; and protein-DNA complex. Implicated in myxoid liposarcoma. Biomarker of pulmonary tuberculosis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AltDDIT3; C/EBP homologous protein; C/EBP zeta; c/EBP-homologous protein 10; C/EBPzeta; CCAAT/enhancer-binding protein homologous protein; CEBPZ; CHOP; CHOP-10; CHOP10; DDIT-3; DNA damage-inducible transcript 3 protein; dna-damage inducible transcript 3; DNA-damage-inducible transcript 3; GADD153; growth arrest and DNA damage-inducible protein GADD153; growth arrest- and DNA damage-inducible; MGC4154
Orthologs:
Mus musculus (house mouse) : Ddit3 (DNA-damage inducible transcript 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ddit3 (DNA-damage inducible transcript 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ddit3 (DNA damage inducible transcript 3)
Pan paniscus (bonobo/pygmy chimpanzee) : DDIT3 (DNA damage inducible transcript 3)
Canis lupus familiaris (dog) : DDIT3 (DNA damage inducible transcript 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ddit3 (DNA damage inducible transcript 3)
Sus scrofa (pig) : DDIT3 (DNA damage inducible transcript 3)
Chlorocebus sabaeus (African green monkey) : DDIT3 (DNA damage inducible transcript 3)
Heterocephalus glaber (naked mole-rat) : Ddit3 (DNA damage inducible transcript 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1257,516,588 - 57,521,737 (-)EnsemblGRCh38hg38GRCh38
GRCh381257,516,588 - 57,520,517 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371257,910,371 - 57,914,300 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361256,196,638 - 56,200,567 (-)NCBINCBI36hg18NCBI36
Build 341256,196,639 - 56,200,567NCBI
Celera1257,566,204 - 57,570,133 (-)NCBI
Cytogenetic Map12q13.3NCBI
HuRef1254,948,369 - 54,952,298 (-)NCBIHuRef
CHM1_11257,878,226 - 57,882,156 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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