DDIT3 (DNA damage inducible transcript 3) - Rat Genome Database

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Gene: DDIT3 (DNA damage inducible transcript 3) Homo sapiens
Symbol: DDIT3
Name: DNA damage inducible transcript 3
RGD ID: 69165
Description: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; cAMP response element binding protein binding activity; and protein dimerization activity. Involved in several processes, including negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding activity; regulation of intracellular signal transduction; and regulation of transcription, DNA-templated. Acts upstream of or within cell redox homeostasis; negative regulation of NF-kappaB transcription factor activity; and regulation of transcription by RNA polymerase II. Located in nucleus. Part of CHOP-ATF3 complex; CHOP-ATF4 complex; and protein-DNA complex. Implicated in myxoid liposarcoma. Biomarker of pulmonary tuberculosis and pulmonary venoocclusive disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AltDDIT3; C/EBP homologous protein; C/EBP zeta; c/EBP-homologous protein 10; C/EBPzeta; CCAAT/enhancer-binding protein homologous protein; CEBPZ; CHOP; CHOP-10; CHOP10; DDIT-3; DNA damage-inducible transcript 3 protein; dna-damage inducible transcript 3; DNA-damage-inducible transcript 3; GADD153; growth arrest and DNA damage-inducible protein GADD153; growth arrest- and DNA damage-inducible; MGC4154
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: CEBPZ (Gene ID: 10153) and DDIT3 (Gene ID: 1649) share the CEBPZ symbol/alias. CEBPZ is a widely used alternative name for DNA damage inducible transcript 3 (DDIT3), which can be confused with the official symbol for CEBPZ (CCAAT enhancer binding protein zeta, GeneID: 10153). [12 Nov 2020]
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1257,516,588 - 57,521,737 (-)EnsemblGRCh38hg38GRCh38
GRCh381257,516,588 - 57,520,517 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371257,910,371 - 57,914,300 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361256,196,638 - 56,200,567 (-)NCBINCBI36hg18NCBI36
Build 341256,196,639 - 56,200,567NCBI
Celera1257,566,204 - 57,570,133 (-)NCBI
Cytogenetic Map12q13.3NCBI
HuRef1254,948,369 - 54,952,298 (-)NCBIHuRef
CHM1_11257,878,226 - 57,882,156 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(+)-schisandrin B  (ISO)
(+)-Tetrandrine  (EXP)
(-)-anisomycin  (EXP)
(-)-citrinin  (EXP)
(-)-demecolcine  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(-)-gambogic acid  (EXP)
(-)-quinic acid  (EXP)
(E)-thiamethoxam  (ISO)
(R)-lipoic acid  (ISO)
(R)-noradrenaline  (ISO)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(R,S)-Scoulerine  (EXP)
(S)-amphetamine  (ISO)
(S)-colchicine  (EXP)
(S)-nicotine  (EXP,ISO)
(Z)-3-butylidenephthalide  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-dithiothreitol  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP,ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (EXP)
14-Deoxy-11,12-didehydroandrographolide  (EXP)
15-acetyldeoxynivalenol  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,3-dimethoxynaphthalene-1,4-dione  (EXP)
2,4,6-trinitrotoluene  (EXP)
2,4-diaminotoluene  (ISO)
2,4-dichlorophenol  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-arachidonoylglycerol  (EXP)
2-butoxyethanol  (ISO)
2-deoxy-D-glucose  (EXP)
2-hydroxypropanoic acid  (EXP)
2-tert-butylhydroquinone  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3'-diindolylmethane  (EXP)
3,4-dihydrocoumarin  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methyladenine  (EXP)
3-phenylprop-2-enal  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (EXP)
4-phenylbutylamine  (ISO)
4-phenylbutyric acid  (EXP,ISO)
4-phenylcoumarin  (ISO)
5-(N,N-hexamethylene)amiloride  (EXP)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
7,12-dimethyltetraphene  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP)
[6]-Shogaol  (EXP)
acetaldehyde  (EXP)
acetamide  (ISO)
acetylsalicylic acid  (EXP,ISO)
acrolein  (EXP,ISO)
acrylamide  (EXP,ISO)
acrylonitrile  (EXP)
afimoxifene  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinal  (EXP)
all-trans-retinoic acid  (EXP,ISO)
allopurinol  (EXP)
alloxan  (ISO)
Aloe emodin  (EXP)
alpha-(methylamino)isobutyric acid  (ISO)
alpha-D-galactose  (EXP)
alpha-naphthoflavone  (ISO)
AM-251  (EXP)
amiloride  (ISO)
amino acid  (ISO)
amiodarone  (EXP,ISO)
ammonium chloride  (ISO)
amosite asbestos  (EXP)
amphibole asbestos  (EXP)
anandamide  (EXP,ISO)
aniline  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimycin A  (EXP,ISO)
antirheumatic drug  (EXP)
apigenin  (ISO)
aristolochic acid  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenic trichloride  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
atazanavir sulfate  (EXP)
atrazine  (EXP)
auraptene  (EXP)
Aurin  (EXP)
azathioprine  (EXP)
azoxystrobin  (EXP)
benomyl  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP,ISO)
bepridil  (EXP)
beta-cyclodextrin  (EXP)
beta-D-glucosamine  (EXP,ISO)
betulinic acid  (EXP,ISO)
bexarotene  (ISO)
bilirubin IXalpha  (EXP,ISO)
biphenyl-4-amine  (EXP)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bisphenol A  (EXP,ISO)
bongkrekic acid  (EXP)
boric acid  (EXP)
borrelidin  (EXP)
bortezomib  (EXP,ISO)
brefeldin A  (EXP,ISO)
Brevetoxin B  (EXP)
bromobenzene  (ISO)
bufalin  (EXP)
butanal  (EXP)
butylated hydroxyanisole  (ISO)
Butylparaben  (EXP)
butyric acid  (EXP,ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
Calcimycin  (EXP,ISO)
calcitriol  (EXP)
calcium carbonate  (EXP)
camptothecin  (EXP)
cannabidiol  (EXP,ISO)
cantharidin  (EXP)
capsaicin  (EXP,ISO)
captan  (EXP)
carbamazepine  (EXP)
carbaryl  (EXP)
carbon atom  (EXP)
carbon nanotube  (EXP,ISO)
carboplatin  (ISO)
carboxy-PTIO  (EXP,ISO)
casticin  (ISO)
celastrol  (EXP)
celecoxib  (EXP)
chenodeoxycholic acid  (EXP)
chloroacetaldehyde  (EXP)
chloroacetic acid  (ISO)
chloroform  (ISO)
chloropicrin  (EXP)
chloroquine  (EXP,ISO)
chlorpromazine  (ISO)
choline  (ISO)
chromium atom  (EXP)
chromium(6+)  (ISO)
chrysazin  (EXP)
chrysophanol  (EXP)
cibenzoline  (EXP)
cidofovir anhydrous  (EXP)
ciglitazone  (EXP)
cimetidine  (ISO)
cisplatin  (EXP,ISO)
clodronic acid  (EXP)
clofibrate  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
cobicistat  (ISO)
cocaine  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (EXP,ISO)
copper(II) sulfate  (EXP)
corticosterone  (ISO)
crocidolite asbestos  (EXP)
crotonaldehyde  (EXP)
Cuprizon  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (EXP)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (EXP)
D-cycloserine  (EXP)
D-glucose  (EXP,ISO)
D-mannopyranose  (EXP)
D-penicillamine  (EXP)
dantrolene  (ISO)
Deguelin  (EXP)
demethoxycurcumin  (EXP)
deoxycholic acid  (EXP)
deoxynivalenol  (EXP,ISO)
desferrioxamine B  (EXP)
desipramine  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
diclofenac  (EXP,ISO)
dicrotophos  (EXP)
dieldrin  (EXP,ISO)
diethyl maleate  (EXP)
diethylstilbestrol  (EXP)
dihydroartemisinin  (EXP)
dihydrocapsaicin  (EXP)
dihydroxyacetone  (EXP)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (EXP)
dimethylarsinous acid  (EXP,ISO)
Dinitramine  (ISO)
dinophysistoxin 1  (EXP)
dioxygen  (EXP,ISO)
diquat  (ISO)
disodium selenite  (EXP)
disulfiram  (EXP)
dorsomorphin  (EXP,ISO)
doxazosin  (ISO)
doxorubicin  (EXP,ISO)
duvoglustat  (ISO)
echinacoside  (EXP)
efavirenz  (EXP)
elemental carbon  (EXP)
emodin  (ISO)
endosulfan  (ISO)
entinostat  (EXP)
erastin  (ISO)
erlotinib hydrochloride  (EXP,ISO)
erythromycin estolate  (ISO)
etacrynic acid  (EXP)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (EXP)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP,ISO)
excitatory amino acid agonist  (ISO)
fangchinoline  (EXP)
fenofibrate  (EXP)
fenpyroximate  (EXP)
ferric oxide  (ISO)
fisetin  (EXP)
flavokawain B  (EXP)
flavonoids  (ISO)
flufenoxuron  (ISO)
fluoranthene  (ISO)
flutamide  (ISO)
folic acid  (EXP,ISO)
folpet  (ISO)
formaldehyde  (EXP)
fumonisin B1  (EXP)
furan  (ISO)
furosemide  (ISO)
gadolinium atom  (ISO)
gadolinium trichloride  (ISO)
galactose  (EXP)
gedunin  (EXP)
genistein  (EXP,ISO)
gentamycin  (ISO)
geraniol  (EXP)
ginsenoside Rg1  (EXP)
glafenine  (EXP)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
glycine  (EXP)
glycochenodeoxycholic acid  (EXP,ISO)
glycocholic acid  (EXP)
glycodeoxycholic acid  (EXP)
glyphosate  (EXP)
gold atom  (EXP)
gold(0)  (EXP)
graphite  (ISO)
Guanabenz  (ISO)
GW 4064  (ISO)
halothane  (ISO)
helenalin  (EXP)
hemin  (ISO)
hexachlorophene  (EXP)
hexadecanoic acid  (EXP,ISO)
homocysteine  (EXP)
hydralazine  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (EXP)
hydroxytyrosol  (ISO)
hypochlorous acid  (ISO)
ifosfamide  (EXP)
Ilimaquinone  (EXP)
indinavir  (EXP)
indometacin  (EXP,ISO)
ionomycin  (ISO)
iprodione  (EXP)
irinotecan  (ISO)
iron atom  (EXP,ISO)
iron(0)  (EXP,ISO)
iron(III) citrate  (EXP)
isoniazide  (EXP,ISO)
isoprenaline  (ISO)
ivermectin  (EXP,ISO)
ketoconazole  (ISO)
KN-93  (ISO)
kojic acid  (ISO)
L-1,4-dithiothreitol  (EXP,ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lactacystin  (EXP)
lamivudine  (EXP)
lead diacetate  (ISO)
lead nitrate  (EXP)
leflunomide  (EXP)
letrozole  (ISO)
Licochalcone B  (EXP)
linagliptin  (ISO)
linoleic acid  (ISO)
linsidomine  (EXP)
lipoic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (ISO)
lomustine  (EXP)
lucanthone  (EXP)
luteolin  (EXP,ISO)
LY294002  (EXP,ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
melatonin  (ISO)
menadione  (EXP)
mercury dibromide  (EXP)
mercury dichloride  (ISO)
metacetamol  (ISO)
metformin  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP,ISO)
methotrexate  (EXP,ISO)
methoxychlor  (ISO)
methyl beta-cyclodextrin  (EXP)
methyl methanesulfonate  (EXP,ISO)
methylisothiazolinone  (EXP)
methylmercury chloride  (EXP,ISO)
methylseleninic acid  (EXP)
methyltestosterone  (EXP)
metyrapone  (EXP)
mevastatin  (ISO)
microcystin-LR  (EXP,ISO)
minocycline  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
monocrotaline  (ISO)
morusin  (EXP)
motexafin gadolinium  (EXP)
myriocin  (EXP)
N,N-dimethylformamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-hexadecanoylsphingosine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methylnicotinate  (EXP)
N-nitrosodiethylamine  (ISO)
naltrexone  (EXP)
nefazodone  (EXP)
nelfinavir  (EXP)
nickel atom  (EXP,ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
niclosamide  (EXP)
nicotine  (EXP,ISO)
nifedipine  (ISO)
Niflumic acid  (EXP)
nilotinib  (EXP)
nimesulide  (EXP,ISO)
nitrofen  (ISO)
nitroprusside  (EXP,ISO)
nobiletin  (EXP,ISO)
Nodularin  (EXP)
Nonidet P-40  (EXP)
nonivamide  (EXP,ISO)
Nonylphenol  (ISO)
Norbinaltorphimine  (EXP)
NS-398  (EXP)
NSC 23766  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (EXP)
olaparib  (EXP)
oleanolic acid  (EXP,ISO)
oleic acid  (EXP)
oleuropein  (ISO)
omeprazole  (EXP)
orlistat  (EXP)
ouabain  (EXP)
oxaliplatin  (ISO)
oxidopamine  (EXP,ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parthenolide  (EXP)
patulin  (EXP)
pemetrexed  (EXP)
pentachlorophenol  (ISO)
perfluorodecanoic acid  (EXP)
perfluorododecanoic acid  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (ISO)
permethrin  (EXP)
phalloidin  (ISO)
phenethyl caffeate  (ISO)
phenethyl isothiocyanate  (EXP)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (EXP)
phenytoin  (ISO)
picoxystrobin  (EXP)
pirinixic acid  (EXP)
piroxicam  (EXP)
platycodin D  (EXP)
plumbagin  (EXP)
poly(guanylic acid)  (ISO)
potassium bromate  (EXP)
potassium chromate  (EXP)
potassium dichromate  (ISO)
potassium iodide  (EXP)
progesterone  (EXP)
propiconazole  (ISO)
prostaglandin E2  (EXP)
Ptaquiloside  (EXP)
pterostilbene  (EXP)
pyrazinecarboxamide  (EXP,ISO)
pyrimidifen  (EXP)
pyrrolidine dithiocarbamate  (EXP,ISO)
quartz  (EXP)
quercetin  (EXP,ISO)
rac-lactic acid  (EXP)
raspberry ketone  (EXP,ISO)
reactive oxygen species  (ISO)
resorcinol  (EXP)
resveratrol  (EXP,ISO)
riboflavin  (EXP)
rifampicin  (EXP,ISO)
rimonabant  (EXP)
rotenone  (EXP,ISO)
rottlerin  (EXP,ISO)
ryanodine  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
Salinomycin  (EXP)
salubrinal  (EXP,ISO)
Salvianolic acid A  (ISO)
salvianolic acid B  (ISO)
SB 203580  (EXP,ISO)
SB 431542  (EXP)
SB-239063  (EXP)
SCH 23390  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
selenomethionine  (ISO)
serpentine asbestos  (ISO)
sertraline  (EXP)
sibutramine  (EXP)
silibinin  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
sirolimus  (EXP,ISO)
SKF-96365 hydrochloride  (ISO)
sodium arsenate  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium dodecyl sulfate  (EXP)
sodium fluoride  (EXP,ISO)
Soman  (ISO)
sorafenib  (EXP)
SR 144528  (EXP)
staurosporine  (EXP)
streptozocin  (ISO)
SU6656  (ISO)
succimer  (ISO)
sulfasalazine  (ISO)
sulforaphane  (EXP,ISO)
sulfur dioxide  (EXP)
sulindac  (EXP)
sunitinib  (EXP)
superoxide  (ISO)
T-2 toxin  (ISO)
tacrine  (EXP)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP)
Tanshinone I  (EXP)
tauroursodeoxycholic acid  (EXP,ISO)
tebufenpyrad  (EXP)
telmisartan  (ISO)
Terfenadine  (EXP)
tert-butyl hydroperoxide  (EXP,ISO)
tetrachloromethane  (ISO)
tetracycline  (ISO)
thalidomide  (EXP)
thapsigargin  (EXP,ISO)
thiamethoxam  (ISO)
thifluzamide  (EXP)
thioacetamide  (ISO)
thiostrepton  (EXP)
thymoquinone  (EXP)
Tiron  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
torin 1  (EXP,ISO)
triacetin  (EXP)
tributyl phosphate  (ISO)
tributylstannane  (EXP)
Tributyltin oxide  (EXP,ISO)
trichloroethene  (ISO)
trimethylamine N-oxide  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
trovafloxacin  (EXP)
tungsten  (ISO)
tunicamycin  (EXP,ISO)
undecane  (ISO)
uranium atom  (EXP)
urethane  (EXP)
ursodeoxycholic acid  (ISO)
ursolic acid  (EXP)
usnic acid  (EXP)
valproic acid  (EXP,ISO)
valsartan  (ISO)
vemurafenib  (EXP)
verapamil  (EXP)
vinclozolin  (ISO)
vincristine  (EXP)
vitexin  (ISO)
WIN 55212-2  (EXP)
withaferin A  (EXP)
wortmannin  (EXP)
zearalenone  (ISO)
zidovudine  (EXP)
zileuton  (ISO)
zinc acetate  (EXP)
zinc atom  (EXP)
zinc oxide  (ISO)
zinc protoporphyrin  (ISO)
zinc pyrithione  (EXP)
zinc(0)  (EXP)
ziram  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
anterior/posterior axis specification  (ISS)
apoptotic process  (ISO)
ATF6-mediated unfolded protein response  (TAS)
blood vessel maturation  (IEA)
cell redox homeostasis  (IDA)
cellular response to DNA damage stimulus  (TAS)
cellular response to manganese ion  (ISO)
embryonic organ development  (ISO)
endoplasmic reticulum unfolded protein response  (ISO,ISS)
ER overload response  (IBA,ISO)
establishment of protein localization to mitochondrion  (IEA)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (IBA,IDA,IMP,ISO,TAS)
intrinsic apoptotic signaling pathway in response to nitrosative stress  (IEA)
luteolysis  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISS)
negative regulation of cold-induced thermogenesis  (ISS)
negative regulation of CREB transcription factor activity  (IBA,IDA,IGI,ISO)
negative regulation of determination of dorsal identity  (IDA)
negative regulation of DNA binding  (ISO)
negative regulation of DNA-binding transcription factor activity  (IDA,IMP)
negative regulation of fat cell differentiation  (IEA,ISO)
negative regulation of interferon-gamma production  (IMP)
negative regulation of interleukin-17 production  (IMP)
negative regulation of interleukin-4 production  (IMP)
negative regulation of myoblast differentiation  (IEA)
negative regulation of NF-kappaB transcription factor activity  (IDA)
negative regulation of protein kinase B signaling  (IMP)
negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding  (IDA)
negative regulation of transcription by RNA polymerase II  (IBA,IDA,IGI,ISS)
negative regulation of transcription, DNA-templated  (IDA)
PERK-mediated unfolded protein response  (TAS)
positive regulation of apoptotic process  (ISO)
positive regulation of autophagy in response to ER overload  (ISO)
positive regulation of DNA-binding transcription factor activity  (IMP,ISS)
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (IC)
positive regulation of interleukin-8 production  (IMP)
positive regulation of intrinsic apoptotic signaling pathway  (IBA,IMP)
positive regulation of neuron apoptotic process  (IC,ISS)
positive regulation of neuron death  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IMP)
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  (IBA,IDA,IGI,IMP,ISS)
positive regulation of transcription, DNA-templated  (IDA,ISO)
proteasome-mediated ubiquitin-dependent protein catabolic process  (IDA)
regulation of autophagy  (ISS)
regulation of transcription by RNA polymerase II  (IDA)
regulation of transcription from RNA polymerase II promoter in response to stress  (TAS)
regulation of transcription, DNA-templated  (IMP,ISO)
release of sequestered calcium ion into cytosol  (IEA)
response to amphetamine  (ISO)
response to endoplasmic reticulum stress  (IDA)
response to hydrogen peroxide  (ISO)
response to nutrient  (ISO)
response to oxidative stress  (ISO)
response to starvation  (IEA)
response to toxic substance  (ISO)
response to unfolded protein  (IDA)
response to xenobiotic stimulus  (ISO)
sensory perception of sound  (IEA,ISO)
Wnt signaling pathway  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype

References - curated
1. Aman P, etal., Genes Chromosomes Cancer. 1992 Nov;5(4):278-85.
2. Bek MF, etal., Am J Pathol. 2006 Jan;168(1):20-32.
3. GOA_HUMAN data from the GO Consortium
4. Li F, etal., Brain Res. 2005 Jun 28;1048(1-2):59-68.
5. Li SS, etal., Ren Fail. 2015 Jun;37(5):890-5. doi: 10.3109/0886022X.2015.1015427. Epub 2015 Feb 24.
6. Li Y, etal., Zhonghua Jie He He Hu Xi Za Zhi. 2014 Jan;37(1):30-5.
7. Liu J, etal., Int J Mol Med. 2018 Nov;42(5):2891-2902. doi: 10.3892/ijmm.2018.3858. Epub 2018 Sep 5.
8. Lu JF, etal., Fa Yi Xue Za Zhi. 2018 Aug;34(4):347-351. doi: 10.12116/j.issn.1004-5619.2018.04.001. Epub 2018 Aug 25.
9. Manaud G, etal., Am J Respir Cell Mol Biol. 2020 Jul;63(1):118-131. doi: 10.1165/rcmb.2019-0015OC.
10. Mulhern ML, etal., Invest Ophthalmol Vis Sci. 2006 Sep;47(9):3951-9.
11. OMIM Disease Annotation Pipeline
12. Pipeline to import KEGG annotations from KEGG into RGD
13. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. RGD automated import pipeline for gene-chemical interactions
15. RGD automated import pipeline for human HPO-to-gene-to-disease annotations
16. Seimon TA, etal., PLoS One. 2010 Sep 15;5(9):e12772. doi: 10.1371/journal.pone.0012772.
17. Sun Y, etal., Curr Vasc Pharmacol. 2017;15(2):174-183. doi: 10.2174/1570161114666161025100656.
18. Sylvester SL, etal., J Biol Chem. 1994 Aug 5;269(31):20119-25.
19. Tan Z, etal., J Neuroinflammation. 2018 Sep 21;15(1):275. doi: 10.1186/s12974-018-1311-5.
20. Williams BL and Lipkin WI, J Virol. 2006 Sep;80(17):8613-26. doi: 10.1128/JVI.00836-06.
21. Yang H, etal., Autophagy. 2020 Feb;16(2):271-288. doi: 10.1080/15548627.2019.1606647. Epub 2019 Apr 21.
22. Zhou H, etal., Toxicol Appl Pharmacol. 2004 Oct 15;200(2):111-20.
Additional References at PubMed
PMID:1339368   PMID:1547942   PMID:1990262   PMID:2372777   PMID:7503811   PMID:8510758   PMID:8622660   PMID:8637704   PMID:8650547   PMID:8662954   PMID:8889549   PMID:10523647  
PMID:10713066   PMID:11478948   PMID:11691921   PMID:11805088   PMID:11948400   PMID:12006103   PMID:12069855   PMID:12082616   PMID:12097650   PMID:12138118   PMID:12168790   PMID:12297725  
PMID:12477932   PMID:12618752   PMID:12706815   PMID:12805554   PMID:12876286   PMID:12939601   PMID:14630918   PMID:14635187   PMID:14667815   PMID:14669326   PMID:14685163   PMID:15001576  
PMID:15053923   PMID:15271854   PMID:15277326   PMID:15286712   PMID:15308577   PMID:15316935   PMID:15322075   PMID:15327748   PMID:15489334   PMID:15588942   PMID:15659384   PMID:15688424  
PMID:15775988   PMID:15870698   PMID:15917187   PMID:16005964   PMID:16081421   PMID:16098044   PMID:16189514   PMID:16331558   PMID:16434966   PMID:16463383   PMID:16511829   PMID:16651630  
PMID:16942595   PMID:16958678   PMID:17171638   PMID:17273769   PMID:17276738   PMID:17468515   PMID:17513780   PMID:17601350   PMID:17616685   PMID:17620318   PMID:17647282   PMID:17652152  
PMID:17686866   PMID:17709599   PMID:17872950   PMID:17968315   PMID:18278507   PMID:18330356   PMID:18394432   PMID:18396163   PMID:18534616   PMID:18541659   PMID:18593935   PMID:18679584  
PMID:18680108   PMID:18772138   PMID:18850010   PMID:18940792   PMID:18977241   PMID:19037087   PMID:19061639   PMID:19107326   PMID:19116245   PMID:19274049   PMID:19470730   PMID:19558691  
PMID:19672300   PMID:19722195   PMID:19723703   PMID:19733664   PMID:19744850   PMID:19816510   PMID:19855386   PMID:19934253   PMID:20017906   PMID:20032083   PMID:20102225   PMID:20116099  
PMID:20122151   PMID:20211142   PMID:20398657   PMID:20424162   PMID:20430872   PMID:20492726   PMID:20554776   PMID:20562859   PMID:20829347   PMID:20876114   PMID:20889551   PMID:21044953  
PMID:21106240   PMID:21179554   PMID:21189163   PMID:21285359   PMID:21365646   PMID:21402790   PMID:21471847   PMID:21479362   PMID:21697087   PMID:21697995   PMID:21700680   PMID:21732477  
PMID:21741997   PMID:21801305   PMID:21873270   PMID:21873635   PMID:21966512   PMID:21988832   PMID:22065586   PMID:22094256   PMID:22096849   PMID:22146569   PMID:22157935   PMID:22242125  
PMID:22246806   PMID:22261448   PMID:22289049   PMID:22496745   PMID:22496840   PMID:22570737   PMID:22609407   PMID:22691366   PMID:22753273   PMID:22761832   PMID:22800509   PMID:22815481  
PMID:22934019   PMID:22995304   PMID:23053497   PMID:23065795   PMID:23213463   PMID:23339468   PMID:23412101   PMID:23546223   PMID:23661758   PMID:23749468   PMID:23836491   PMID:24038088  
PMID:24060278   PMID:24078627   PMID:24270407   PMID:24285420   PMID:24287694   PMID:24339898   PMID:24351550   PMID:24367269   PMID:24367283   PMID:24565834   PMID:24598693   PMID:24625971  
PMID:24738922   PMID:24781973   PMID:24939851   PMID:24952347   PMID:24963104   PMID:24990631   PMID:24994112   PMID:25032846   PMID:25192658   PMID:25270224   PMID:25343248   PMID:25387528  
PMID:25409632   PMID:25416956   PMID:25532011   PMID:25643991   PMID:25770212   PMID:26090483   PMID:26125799   PMID:26174226   PMID:26259235   PMID:26264872   PMID:26370079   PMID:26384350  
PMID:26486079   PMID:26504039   PMID:26740125   PMID:26865464   PMID:26883801   PMID:27031958   PMID:27107012   PMID:27107014   PMID:27173017   PMID:27189710   PMID:27211800   PMID:27239734  
PMID:27260301   PMID:27267997   PMID:27496643   PMID:27555288   PMID:27573888   PMID:27599983   PMID:27627987   PMID:27771295   PMID:27856178   PMID:27895089   PMID:28215707   PMID:28238747  
PMID:28270124   PMID:28393217   PMID:28507169   PMID:28522833   PMID:28586043   PMID:28618969   PMID:28637688   PMID:28652211   PMID:28694294   PMID:28853202   PMID:28891115   PMID:28947141  
PMID:29089376   PMID:29127866   PMID:29190494   PMID:29315574   PMID:29371697   PMID:29702190   PMID:29910063   PMID:29997244   PMID:30135303   PMID:30165670   PMID:30420727   PMID:30755730  
PMID:30894532   PMID:30902789   PMID:30912739   PMID:30962207   PMID:31025089   PMID:31467278   PMID:31586073   PMID:31642559   PMID:31901873   PMID:32118311   PMID:32210535   PMID:32296183  
PMID:32513696   PMID:32639626   PMID:32723872   PMID:32814053   PMID:32815829   PMID:32911434   PMID:32990902   PMID:33004975   PMID:33384352   PMID:33403797   PMID:33562298   PMID:33751936  
PMID:33911065   PMID:33916874  


Comparative Map Data
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1257,516,588 - 57,521,737 (-)EnsemblGRCh38hg38GRCh38
GRCh381257,516,588 - 57,520,517 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371257,910,371 - 57,914,300 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361256,196,638 - 56,200,567 (-)NCBINCBI36hg18NCBI36
Build 341256,196,639 - 56,200,567NCBI
Celera1257,566,204 - 57,570,133 (-)NCBI
Cytogenetic Map12q13.3NCBI
HuRef1254,948,369 - 54,952,298 (-)NCBIHuRef
CHM1_11257,878,226 - 57,882,156 (-)NCBICHM1_1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3910127,126,662 - 127,132,160 (+)NCBIGRCm39mm39
GRCm39 Ensembl10127,126,643 - 127,132,157 (+)Ensembl
GRCm39 Ensembl10127,126,698 - 127,129,622 (+)Ensembl
GRCm3810127,290,793 - 127,296,291 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,290,774 - 127,296,288 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,290,829 - 127,293,753 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710126,727,849 - 126,733,344 (+)NCBIGRCm37mm9NCBIm37
MGSCv3610126,693,759 - 126,699,235 (+)NCBImm8
Celera10129,683,104 - 129,688,599 (+)NCBICelera
Cytogenetic Map10D3NCBI
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2763,115,645 - 63,121,203 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl763,116,380 - 63,121,201 (+)Ensembl
Rnor_6.0770,578,564 - 70,585,074 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl770,580,198 - 70,585,084 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0770,753,800 - 70,759,220 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4767,247,749 - 67,252,571 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1767,268,487 - 67,273,294 (+)NCBI
Celera760,256,651 - 60,261,474 (+)NCBICelera
Cytogenetic Map7q22NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554585,232,979 - 5,238,513 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554585,232,979 - 5,238,513 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.11231,664,766 - 31,668,699 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1231,664,743 - 31,668,701 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01231,406,332 - 31,410,293 (+)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1101,606,693 - 1,612,410 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl101,606,693 - 1,611,303 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha101,669,927 - 1,675,567 (-)NCBI
ROS_Cfam_1.0101,615,759 - 1,621,400 (-)NCBI
UMICH_Zoey_3.1101,593,774 - 1,599,407 (-)NCBI
UNSW_CanFamBas_1.0101,835,463 - 1,841,297 (-)NCBI
UU_Cfam_GSD_1.0101,960,652 - 1,966,292 (-)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494557,201,026 - 57,205,216 (+)NCBI
SpeTri2.0NW_0049366461,665,019 - 1,669,212 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl522,785,441 - 22,791,134 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1522,785,441 - 22,789,867 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11153,424,693 - 53,429,094 (-)NCBI
ChlSab1.1 Ensembl1153,424,868 - 53,425,576 (-)Ensembl
Vero_WHO_p1.0NW_023666037192,535,088 - 192,539,471 (+)NCBI
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_00462480210,437,998 - 10,443,278 (+)NCBI

Position Markers
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371257,910,442 - 57,910,591UniSTSGRCh37
Build 361256,196,709 - 56,196,858RGDNCBI36
Celera1257,566,275 - 57,566,424RGD
Cytogenetic Map12q13.1-q13.2UniSTS
Cytogenetic Map12q13UniSTS
HuRef1254,948,440 - 54,948,589UniSTS
Whitehead-YAC Contig Map12 UniSTS
GeneMap99-G3 RH Map122300.0UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371257,910,435 - 57,911,537UniSTSGRCh37
Build 361256,196,702 - 56,197,804RGDNCBI36
Celera1257,566,268 - 57,567,370RGD
Cytogenetic Map12q13.1-q13.2UniSTS
HuRef1254,948,433 - 54,949,535UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371257,910,262 - 57,910,382UniSTSGRCh37
Build 361256,196,529 - 56,196,649RGDNCBI36
Celera1257,566,095 - 57,566,215RGD
Cytogenetic Map12q13.1-q13.2UniSTS
Cytogenetic Map12q13UniSTS
HuRef1254,948,260 - 54,948,380UniSTS
GeneMap99-GB4 RH Map12254.74UniSTS
NCBI RH Map12458.1UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371257,910,591 - 57,910,892UniSTSGRCh37
Build 361256,196,858 - 56,197,159RGDNCBI36
Celera1257,566,424 - 57,566,725RGD
Cytogenetic Map12q13.1-q13.2UniSTS
Cytogenetic Map12q13UniSTS
HuRef1254,948,589 - 54,948,890UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371257,910,476 - 57,910,628UniSTSGRCh37
Build 361256,196,743 - 56,196,895RGDNCBI36
Celera1257,566,309 - 57,566,461RGD
Cytogenetic Map12q13.1-q13.2UniSTS
Cytogenetic Map12q13UniSTS
HuRef1254,948,474 - 54,948,626UniSTS
GeneMap99-GB4 RH Map12254.74UniSTS
NCBI RH Map12458.1UniSTS
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map21q22.2UniSTS
Cytogenetic Map3p24.2UniSTS
Cytogenetic Map7p14.1UniSTS
Cytogenetic Map5q31.2UniSTS
Cytogenetic Map1p36.32UniSTS
Cytogenetic Map2p25.1UniSTS
Cytogenetic Map22q11.22UniSTS
Cytogenetic Map14q32.3UniSTS
Cytogenetic Map19p13.2UniSTS
Cytogenetic Map17q11UniSTS
Cytogenetic Map17q21UniSTS
Cytogenetic Map9q34.13UniSTS
Cytogenetic Map10p13UniSTS
Cytogenetic Map3q27UniSTS
Cytogenetic Map14q22.3UniSTS
Cytogenetic Map7q22.1UniSTS
Cytogenetic Map9q34.3UniSTS
Cytogenetic Map4q32.2UniSTS
Cytogenetic Map1p34.2UniSTS
Cytogenetic Map12p13.31UniSTS
Cytogenetic Map3p21.1UniSTS
Cytogenetic Map10p15.3UniSTS
Cytogenetic Map19q13.13UniSTS
Cytogenetic Map17q21.33UniSTS
Cytogenetic Map22q13.33UniSTS
Cytogenetic Map5q23.3UniSTS
Cytogenetic Map16q22.1UniSTS
Cytogenetic Map12q24.13UniSTS
Cytogenetic MapXp11.23UniSTS
Cytogenetic Map19q13.3UniSTS