DDIT3 (DNA damage inducible transcript 3)

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Gene: DDIT3 (DNA damage inducible transcript 3) Canis lupus familiaris

Analyze

Symbol:

DDIT3

Name:

DNA damage inducible transcript 3

RGD ID:

12169167

Description:

ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription factor activity (ortholog); protein homodimerization activity (ortholog); INVOLVED IN aging (ortholog); cell redox homeostasis (ortholog); cellular response to manganese ion (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); Acute Lung Injury (ortholog); Acute-Phase Reaction (ortholog); FOUND IN CHOP-C/EBP complex (ortholog); cytoplasm (ortholog); nucleus (ortholog); INTERACTS WITH ofloxacin

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

DNA damage-inducible transcript 3 protein

RGD Orthologs

Human

Mouse

Rat

Chinchilla

Bonobo

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	1,606,693 - 1,612,410 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	1,606,693 - 1,611,303 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	1,669,927 - 1,675,567 (-)	NCBI
ROS_Cfam_1.0	10	1,615,759 - 1,621,400 (-)	NCBI
ROS_Cfam_1.0 Ensembl	10	1,615,759 - 1,620,369 (-)	Ensembl
UMICH_Zoey_3.1	10	1,593,774 - 1,599,407 (-)	NCBI
UNSW_CanFamBas_1.0	10	1,835,463 - 1,841,297 (-)	NCBI
UU_Cfam_GSD_1.0	10	1,960,652 - 1,966,292 (-)	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute kidney failure (ISO)

Acute Lung Injury (ISO)

Acute-Phase Reaction (ISO)

asbestosis (ISO)

borna disease (ISO)

brain ischemia (ISO)

Breast Neoplasms (ISO)

chronic obstructive pulmonary disease (ISO)

contact dermatitis (ISO)

Contrast-Induced Nephropathy (ISO)

fatty liver disease (ISO)

galactosemia (ISO)

intestinal disease (ISO)

juvenile rheumatoid arthritis (ISO)

myocardial infarction (ISO)

myxoid liposarcoma (ISO)

nephrosis (ISO)

obesity (ISO)

ocular hypertension (ISO)

pulmonary tuberculosis (ISO)

pulmonary venoocclusive disease (ISO)

Spinal Cord Injuries (ISO)

Subarachnoid Hemorrhage (ISO)

Temporomandibular Joint Osteoarthritis (ISO)

type 1 diabetes mellitus (ISO)

Ulcer (ISO)

ureteral obstruction (ISO)

Zika fever (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

ofloxacin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

aging (ISO)

anterior/posterior axis specification (IEA)

apoptotic process (IEA)

artery development (IEA)

blood vessel maturation (IEA)

cell redox homeostasis (IEA,ISO)

cellular response to manganese ion (ISO)

embryonic organ development (ISO)

endoplasmic reticulum unfolded protein response (IEA,ISO)

ER overload response (IBA,IEA,ISO)

establishment of protein localization to mitochondrion (IEA)

gene expression (IEA)

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (IBA,IEA,ISO)

intrinsic apoptotic signaling pathway in response to nitrosative stress (IEA)

luteolysis (ISO)

negative regulation of canonical Wnt signaling pathway (IEA)

negative regulation of cold-induced thermogenesis (IEA)

negative regulation of CREB transcription factor activity (IBA,IEA,ISO)

negative regulation of determination of dorsal identity (IEA)

negative regulation of DNA binding (IEA,ISO)

negative regulation of DNA-binding transcription factor activity (IEA)

negative regulation of DNA-templated transcription (IEA)

negative regulation of fat cell differentiation (IEA,ISO)

negative regulation of interleukin-17 production (IEA,ISO)

negative regulation of interleukin-4 production (IEA,ISO)

negative regulation of myoblast differentiation (IEA)

negative regulation of NF-kappaB transcription factor activity (IEA,ISO)

negative regulation of protein kinase B signaling (IEA)

negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding (IEA)

negative regulation of transcription by RNA polymerase II (IBA,IEA)

negative regulation of type II interferon production (IEA,ISO)

positive regulation of apoptotic process (ISO)

positive regulation of autophagy in response to ER overload (ISO)

positive regulation of DNA-binding transcription factor activity (IEA)

positive regulation of DNA-templated transcription (IEA,ISO)

positive regulation of interleukin-8 production (IEA)

positive regulation of intrinsic apoptotic signaling pathway (IBA,IEA)

positive regulation of neuron apoptotic process (IEA)

positive regulation of neuron death (IEA)

positive regulation of transcription by RNA polymerase II (IEA)

positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress (IBA,IEA)

proteasome-mediated ubiquitin-dependent protein catabolic process (IEA)

regulation of autophagy (ISO)

regulation of cell cycle (IEA)

regulation of DNA-templated transcription (IEA,ISO)

regulation of transcription by RNA polymerase II (IEA,ISO)

release of sequestered calcium ion into cytosol (IEA)

response to amphetamine (ISO)

response to endoplasmic reticulum stress (IEA)

response to hydrogen peroxide (ISO)

response to nutrient (ISO)

response to oxidative stress (ISO)

response to platelet-derived growth factor (IEA)

response to starvation (IEA)

response to toxic substance (ISO)

response to unfolded protein (IEA)

response to wounding (IEA)

response to xenobiotic stimulus (ISO)

sensory perception of sound (IEA,ISO)

vascular associated smooth muscle cell migration (IEA)

vascular associated smooth muscle cell proliferation (IEA)

Wnt signaling pathway (IEA)

Cellular Component

CHOP-ATF3 complex (IBA,IEA)

CHOP-ATF4 complex (IBA,IEA)

CHOP-C/EBP complex (IBA,IEA,ISO)

cytoplasm (IBA,IEA,ISO)

late endosome (IEA)

nucleus (IEA,ISO)

protein-DNA complex (IEA)

RNA polymerase II transcription regulator complex (IEA,ISO)

Molecular Function

cAMP response element binding protein binding (IEA)

DNA binding (IEA,ISO)

DNA-binding transcription activator activity, RNA polymerase II-specific (IBA,IEA)

DNA-binding transcription factor activity (IEA,ISO)

identical protein binding (IEA)

leucine zipper domain binding (IEA)

protein binding (ISO)

protein heterodimerization activity (IBA,IEA)

protein homodimerization activity (IEA,ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IBA,IEA)

RNA polymerase II-specific DNA-binding transcription factor binding (IEA)

sequence-specific DNA binding (ISO)

transcription cis-regulatory region binding (IEA)

transcription regulator inhibitor activity (IEA)

References

Genomics

Comparative Map Data

DDIT3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	1,606,693 - 1,612,410 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	1,606,693 - 1,611,303 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	1,669,927 - 1,675,567 (-)	NCBI
ROS_Cfam_1.0	10	1,615,759 - 1,621,400 (-)	NCBI
ROS_Cfam_1.0 Ensembl	10	1,615,759 - 1,620,369 (-)	Ensembl
UMICH_Zoey_3.1	10	1,593,774 - 1,599,407 (-)	NCBI
UNSW_CanFamBas_1.0	10	1,835,463 - 1,841,297 (-)	NCBI
UU_Cfam_GSD_1.0	10	1,960,652 - 1,966,292 (-)	NCBI

DDIT3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	57,516,588 - 57,521,698 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	12	57,516,588 - 57,521,737 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	57,910,371 - 57,914,300 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	56,196,638 - 56,200,567 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	12	56,196,639 - 56,200,567	NCBI
Celera	12	57,566,204 - 57,570,133 (-)	NCBI
Cytogenetic Map	12	q13.3	NCBI
HuRef	12	54,948,369 - 54,952,298 (-)	NCBI		HuRef
CHM1_1	12	57,878,226 - 57,882,156 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	57,484,816 - 57,488,745 (-)	NCBI

Ddit3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	127,126,662 - 127,132,160 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	10	127,126,643 - 127,132,157 (+)	Ensembl
GRCm39 Ensembl	10	127,126,698 - 127,129,622 (+)	Ensembl
GRCm38	10	127,290,793 - 127,296,291 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	127,290,774 - 127,296,288 (+)	Ensembl	GRCm38		mm10	GRCm38
GRCm38.p6 Ensembl	10	127,290,829 - 127,293,753 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	126,727,849 - 126,733,344 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	10	126,693,759 - 126,699,235 (+)	NCBI			mm8
Celera	10	129,683,104 - 129,688,599 (+)	NCBI		Celera
Cytogenetic Map	10	D3	NCBI

Ddit3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	63,115,645 - 63,121,203 (+)	NCBI	mRatBN7.2
mRatBN7.2 Ensembl	7	63,116,380 - 63,121,201 (+)	Ensembl
Rnor_6.0	7	70,578,564 - 70,585,074 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	70,580,198 - 70,585,084 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	70,753,800 - 70,759,220 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	67,247,749 - 67,252,571 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	7	67,268,487 - 67,273,294 (+)	NCBI
Celera	7	60,256,651 - 60,261,474 (+)	NCBI		Celera
Cytogenetic Map	7	q22	NCBI

Ddit3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955458	5,232,979 - 5,238,513 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955458	5,232,979 - 5,238,513 (-)	NCBI	ChiLan1.0	ChiLan1.0

DDIT3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	12	31,664,766 - 31,668,699 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	31,664,743 - 31,668,701 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	12	31,406,332 - 31,410,293 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

Ddit3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	57,201,026 - 57,205,216 (+)	NCBI
SpeTri2.0	NW_004936646	1,665,019 - 1,669,212 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DDIT3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	22,785,445 - 22,789,829 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	22,785,441 - 22,789,867 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

DDIT3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	53,424,693 - 53,429,094 (-)	NCBI	ChlSab1.1		chlSab2
ChlSab1.1 Ensembl	11	53,424,868 - 53,425,576 (-)	Ensembl	ChlSab1.1		chlSab2
Vero_WHO_p1.0	NW_023666037	192,535,088 - 192,539,471 (+)	NCBI	Vero_WHO_p1.0

Ddit3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624802	10,437,998 - 10,443,278 (+)	NCBI	HetGla_female_1.0		hetGla2

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	reproductive system	respiratory system	adipose tissue
High
Medium		4	17	1	5	1		3	11	8	10	1
Low	5	1	5	5	1	5	6	3	1			5
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005625542	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_014117187	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022424097	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038487894	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038487895	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038549788	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038549789	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038613750	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038613751	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038679110	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038679111	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000097	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000358	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSCAFT00000047972 ⟹ ENSCAFP00000039330

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	10	1,606,693 - 1,611,303 (-)	Ensembl

RefSeq Acc Id:

ENSCAFT00845021502 ⟹ ENSCAFP00845016899

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	10	1,615,759 - 1,620,369 (-)	Ensembl

RefSeq Acc Id:

XM_014117187 ⟹ XP_013972662

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	10	1,606,693 - 1,611,378 (-)	NCBI
Dog10K_Boxer_Tasha	10	1,669,927 - 1,674,607 (-)	NCBI

Sequence:

show sequence

GCCCGCCCCCGAGGGGAGGGCAGGGCCTCCTTAAAACATCCGCGCTCGGGCCTCCGAGGTCAGA
GGCTTGAGTGTAAGGCACAGAGCGGATCATGTTGAAGATGAGCGGGTGGCAGCCACAGAGCCAC
AGTCAGAGCCGGAACCTGAGGAGAGAGTGTTCCAGAAGGAAGTGTATCTTCATACATCACCACA
CCTGAGAGCAGAGCCTGATCCAACTGTAGAGATGGCAGCTGAGTCACTGCCTTTTTCCTTCGGG
GCACTGTCCAGCTGGGAGCTGGAAGCCTGGTATGAGGACCTGCAGGAGGTACTGTCCTCAGATG
AAAATGGGGGTACCTGTGTTTCACCCCCTGGAAACAAGGAGGAAGAATCAAAAACCTTCACCAC
TCTGGACCCTGCCTCTCTGGCTTGGCTGACTGAGGAGCCAGGACCAGCAGAGGTCACGAACACC
TTCCAGAGCCCTCACTCTCCAGATTCCAGTCACAGCTCCCTGGCTCAAGAGGAGGAAGAGGAAG
ACCAAAAAAGACCTAGGAAACGGAAACAGAGTGGCCAGTCCCCAGCTGGGGCTGGAAAGCAACG
CATGAAGGAGAAAGAACAAGAGAACGAGAGGAAAGTGGCACAGCTAGCCGAAGAGAATGAACGG
CTCAAGCAGGAAATCGAGCGCCTGACCAGGGAAGTAGAGGCGACTCGCCGGGCTCTGATTGACC
GAATGGTTAATCTGCACCAAGCATGAACAGCTGGGACCATCACTTCCCCCCTTGGGCCACTACC
TACCTTTCACAGACGTGGCTGCTGATCATCTTCTCCAGTGCCAACGATGTGACCCTCAACCCCA
TCTATTCAGTAGGGGGAAAGCTTGGGGTAGGCAAGAGCATGTATATAGAGATTGTACATTTATT
TATTATTATCCATATCCATTAAAGTAACTTTCTATGA

hide sequence

RefSeq Acc Id:

XM_022424097 ⟹ XP_022279805

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	10	1,606,693 - 1,612,410 (-)	NCBI
Dog10K_Boxer_Tasha	10	1,669,927 - 1,675,567 (-)	NCBI

Sequence:

show sequence

GGGCAAGTAAAGGGGCAGGTGAGGCCAGACTCTGGGCTCCTGACAACCCGGTGCAAGGCGGCTG
CGCGCTCAAGTGCACCCAACGTCCCAGGCAACGAGGCTCTAAGGTCGCCCGAGCACCGAGGCGG
CAGGCGGCGGGTGCACGGCTCCTCACGCAGGAGTCACAGGACCTGCGCGGCTGTGTTCCAGAAG
GAAGTGTATCTTCATACATCACCACACCTGAGAGCAGAGCCTGATCCAACTGTAGAGATGGCAG
CTGAGTCACTGCCTTTTTCCTTCGGGGCACTGTCCAGCTGGGAGCTGGAAGCCTGGTATGAGGA
CCTGCAGGAGGTACTGTCCTCAGATGAAAATGGGGGTACCTGTGTTTCACCCCCTGGAAACAAG
GAGGAAGAATCAAAAACCTTCACCACTCTGGACCCTGCCTCTCTGGCTTGGCTGACTGAGGAGC
CAGGACCAGCAGAGGTCACGAACACCTTCCAGAGCCCTCACTCTCCAGATTCCAGTCACAGCTC
CCTGGCTCAAGAGGAGGAAGAGGAAGACCAAAAAAGACCTAGGAAACGGAAACAGAGTGGCCAG
TCCCCAGCTGGGGCTGGAAAGCAACGCATGAAGGAGAAAGAACAAGAGAACGAGAGGAAAGTGG
CACAGCTAGCCGAAGAGAATGAACGGCTCAAGCAGGAAATCGAGCGCCTGACCAGGGAAGTAGA
GGCGACTCGCCGGGCTCTGATTGACCGAATGGTTAATCTGCACCAAGCATGAACAGCTGGGACC
ATCACTTCCCCCCTTGGGCCACTACCTACCTTTCACAGACGTGGCTGCTGATCATCTTCTCCAG
TGCCAACGATGTGACCCTCAACCCCATCTATTCAGTAGGGGGAAAGCTTGGGGTAGGCAAGAGC
ATGTATATAGAGATTGTACATTTATTTATTATTATCCATATCCATTAAAGTAACTTTCTATGA

hide sequence

RefSeq Acc Id:

XM_038487894 ⟹ XP_038343822

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	10	1,593,774 - 1,598,449 (-)	NCBI

RefSeq Acc Id:

XM_038487895 ⟹ XP_038343823

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UMICH_Zoey_3.1	10	1,593,774 - 1,599,407 (-)	NCBI

RefSeq Acc Id:

XM_038549788 ⟹ XP_038405716

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	10	1,960,652 - 1,965,332 (-)	NCBI

RefSeq Acc Id:

XM_038549789 ⟹ XP_038405717

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UU_Cfam_GSD_1.0	10	1,960,652 - 1,966,292 (-)	NCBI

RefSeq Acc Id:

XM_038613750 ⟹ XP_038469678

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	10	1,835,463 - 1,840,337 (-)	NCBI

RefSeq Acc Id:

XM_038613751 ⟹ XP_038469679

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
UNSW_CanFamBas_1.0	10	1,835,463 - 1,841,297 (-)	NCBI

RefSeq Acc Id:

XM_038679110 ⟹ XP_038535038

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	10	1,615,759 - 1,620,439 (-)	NCBI

RefSeq Acc Id:

XM_038679111 ⟹ XP_038535039

RefSeq Status:

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	10	1,615,759 - 1,621,400 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_013972662	(Get FASTA)	NCBI Sequence Viewer
	XP_022279805	(Get FASTA)	NCBI Sequence Viewer
	XP_038343822	(Get FASTA)	NCBI Sequence Viewer
	XP_038343823	(Get FASTA)	NCBI Sequence Viewer
	XP_038405716	(Get FASTA)	NCBI Sequence Viewer
	XP_038405717	(Get FASTA)	NCBI Sequence Viewer
	XP_038469678	(Get FASTA)	NCBI Sequence Viewer
	XP_038469679	(Get FASTA)	NCBI Sequence Viewer
	XP_038535038	(Get FASTA)	NCBI Sequence Viewer
	XP_038535039	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	XP_013972662 ⟸ XM_014117187
- UniProtKB:	J9P1A6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAAESLPFSFGALSSWELEAWYEDLQEVLSSDENGGTCVSPPGNKEEESKTFTTLDPASLAWLT EEPGPAEVTNTFQSPHSPDSSHSSLAQEEEEEDQKRPRKRKQSGQSPAGAGKQRMKEKEQENER KVAQLAEENERLKQEIERLTREVEATRRALIDRMVNLHQA hide sequence

RefSeq Acc Id:	XP_022279805 ⟸ XM_022424097
- Sequence:	show sequence MAAESLPFSFGALSSWELEAWYEDLQEVLSSDENGGTCVSPPGNKEEESKTFTTLDPASLAWLT EEPGPAEVTNTFQSPHSPDSSHSSLAQEEEEEDQKRPRKRKQSGQSPAGAGKQRMKEKEQENER KVAQLAEENERLKQEIERLTREVEATRRALIDRMVNLHQA hide sequence

RefSeq Acc Id:

ENSCAFP00000039330 ⟸ ENSCAFT00000047972

RefSeq Acc Id:

XP_038343823 ⟸ XM_038487895

RefSeq Acc Id:

XP_038343822 ⟸ XM_038487894

RefSeq Acc Id:

XP_038469679 ⟸ XM_038613751

RefSeq Acc Id:

XP_038469678 ⟸ XM_038613750

RefSeq Acc Id:

XP_038535039 ⟸ XM_038679111

RefSeq Acc Id:

XP_038535038 ⟸ XM_038679110

RefSeq Acc Id:

XP_038405717 ⟸ XM_038549789

RefSeq Acc Id:

XP_038405716 ⟸ XM_038549788

RefSeq Acc Id:

ENSCAFP00845016899 ⟸ ENSCAFT00845021502

Protein Domains

bZIP

Promoters

RGD ID:

13684885

Promoter ID:

EPDNEW_C2953

Type:

single initiation site

Name:

DDIT3_1

Description:

DNA damage inducible transcript 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	10	1,608,655 - 1,608,715	EPDNEW

Damaging Variants

Assembly: CanFam3.1

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
10	1607025	1607026	G	C	snv	Great Lakes Wolf (SRS661486)
10	1607397	1607398	T	G	snv	Chinese indigenous dogs (DQ4), Chinese indigenous dogs (DQ8), Tibetan Mastiff (TM8), Chinese indigenous dogs (LJ10), Portuguese Wolf (SRS661492), Spanish Wolf (SRS661495), Tibetan Mastiff (TM1), Tibetan Mastiff (TM6), Chinese indigenous dogs (DQ10), Iranian Wolf (SRS661488)

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000030112	Ensembl
	ENSCAFG00030007751	UniProtKB/TrEMBL
	ENSCAFG00040014608	UniProtKB/TrEMBL
	ENSCAFG00845012093	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSCAFP00030012426.1	UniProtKB/TrEMBL
	ENSCAFP00040023407	UniProtKB/TrEMBL
	ENSCAFP00845016899	ENTREZGENE
	ENSCAFP00845016899.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00030014253.1	UniProtKB/TrEMBL
	ENSCAFT00040026931	UniProtKB/TrEMBL
	ENSCAFT00845021502	ENTREZGENE
	ENSCAFT00845021502.1	UniProtKB/TrEMBL
InterPro	bZIP	UniProtKB/TrEMBL
	DNA_damage_induc_transcript_3	UniProtKB/TrEMBL
NCBI Gene	DDIT3	ENTREZGENE
PANTHER	PTHR16833	UniProtKB/TrEMBL
PIRSF	C/EBPzeta_CHOP_DDIT3	UniProtKB/TrEMBL
PROSITE	BZIP	UniProtKB/TrEMBL
SMART	BRLZ	UniProtKB/TrEMBL
UniProt	A0A8C0MS70_CANLF	UniProtKB/TrEMBL
	A0A8I3NHJ0_CANLF	UniProtKB/TrEMBL
	J9P1A6	ENTREZGENE
VGNC ID	VGNC:39836	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD