DDIT3 (DNA damage inducible transcript 3) - Rat Genome Database

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Gene: DDIT3 (DNA damage inducible transcript 3) Canis lupus familiaris
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Symbol: DDIT3
Name: DNA damage inducible transcript 3
RGD ID: 12169167
Description: ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription factor activity (ortholog); protein homodimerization activity (ortholog); INVOLVED IN aging (ortholog); cell redox homeostasis (ortholog); cellular response to manganese ion (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); Acute Lung Injury (ortholog); Acute-Phase Reaction (ortholog); FOUND IN CHOP-C/EBP complex (ortholog); cytoplasm (ortholog); nucleus (ortholog); INTERACTS WITH ofloxacin
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DNA damage-inducible transcript 3 protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1101,606,693 - 1,612,410 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl101,606,693 - 1,611,303 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha101,669,927 - 1,675,567 (-)NCBI
ROS_Cfam_1.0101,615,759 - 1,621,400 (-)NCBI
ROS_Cfam_1.0 Ensembl101,615,759 - 1,620,369 (-)Ensembl
UMICH_Zoey_3.1101,593,774 - 1,599,407 (-)NCBI
UNSW_CanFamBas_1.0101,835,463 - 1,841,297 (-)NCBI
UU_Cfam_GSD_1.0101,960,652 - 1,966,292 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
ofloxacin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
anterior/posterior axis specification  (IEA)
apoptotic process  (IEA)
artery development  (IEA)
blood vessel maturation  (IEA)
cell redox homeostasis  (IEA,ISO)
cellular response to manganese ion  (ISO)
embryonic organ development  (ISO)
endoplasmic reticulum unfolded protein response  (IEA,ISO)
ER overload response  (IBA,IEA,ISO)
establishment of protein localization to mitochondrion  (IEA)
gene expression  (IEA)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (IBA,IEA,ISO)
intrinsic apoptotic signaling pathway in response to nitrosative stress  (IEA)
luteolysis  (ISO)
negative regulation of canonical Wnt signaling pathway  (IEA)
negative regulation of cold-induced thermogenesis  (IEA)
negative regulation of CREB transcription factor activity  (IBA,IEA,ISO)
negative regulation of determination of dorsal identity  (IEA)
negative regulation of DNA binding  (IEA,ISO)
negative regulation of DNA-binding transcription factor activity  (IEA)
negative regulation of DNA-templated transcription  (IEA)
negative regulation of fat cell differentiation  (IEA,ISO)
negative regulation of interleukin-17 production  (IEA,ISO)
negative regulation of interleukin-4 production  (IEA,ISO)
negative regulation of myoblast differentiation  (IEA)
negative regulation of NF-kappaB transcription factor activity  (IEA,ISO)
negative regulation of protein kinase B signaling  (IEA)
negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding  (IEA)
negative regulation of transcription by RNA polymerase II  (IBA,IEA)
negative regulation of type II interferon production  (IEA,ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of autophagy in response to ER overload  (ISO)
positive regulation of DNA-binding transcription factor activity  (IEA)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of interleukin-8 production  (IEA)
positive regulation of intrinsic apoptotic signaling pathway  (IBA,IEA)
positive regulation of neuron apoptotic process  (IEA)
positive regulation of neuron death  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA)
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  (IBA,IEA)
proteasome-mediated ubiquitin-dependent protein catabolic process  (IEA)
regulation of autophagy  (ISO)
regulation of cell cycle  (IEA)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IEA,ISO)
release of sequestered calcium ion into cytosol  (IEA)
response to amphetamine  (ISO)
response to endoplasmic reticulum stress  (IEA)
response to hydrogen peroxide  (ISO)
response to nutrient  (ISO)
response to oxidative stress  (ISO)
response to platelet-derived growth factor  (IEA)
response to starvation  (IEA)
response to toxic substance  (ISO)
response to unfolded protein  (IEA)
response to wounding  (IEA)
response to xenobiotic stimulus  (ISO)
sensory perception of sound  (IEA,ISO)
vascular associated smooth muscle cell migration  (IEA)
vascular associated smooth muscle cell proliferation  (IEA)
Wnt signaling pathway  (IEA)

Cellular Component

References

Genomics

Comparative Map Data
DDIT3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1101,606,693 - 1,612,410 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl101,606,693 - 1,611,303 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha101,669,927 - 1,675,567 (-)NCBI
ROS_Cfam_1.0101,615,759 - 1,621,400 (-)NCBI
ROS_Cfam_1.0 Ensembl101,615,759 - 1,620,369 (-)Ensembl
UMICH_Zoey_3.1101,593,774 - 1,599,407 (-)NCBI
UNSW_CanFamBas_1.0101,835,463 - 1,841,297 (-)NCBI
UU_Cfam_GSD_1.0101,960,652 - 1,966,292 (-)NCBI
DDIT3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381257,516,588 - 57,521,698 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1257,516,588 - 57,521,737 (-)EnsemblGRCh38hg38GRCh38
GRCh371257,910,371 - 57,914,300 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361256,196,638 - 56,200,567 (-)NCBINCBI36hg18NCBI36
Build 341256,196,639 - 56,200,567NCBI
Celera1257,566,204 - 57,570,133 (-)NCBI
Cytogenetic Map12q13.3NCBI
HuRef1254,948,369 - 54,952,298 (-)NCBIHuRef
CHM1_11257,878,226 - 57,882,156 (-)NCBICHM1_1
T2T-CHM13v2.01257,484,816 - 57,488,745 (-)NCBI
Ddit3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910127,126,662 - 127,132,160 (+)NCBIGRCm39mm39
GRCm39 Ensembl10127,126,643 - 127,132,157 (+)Ensembl
GRCm39 Ensembl10127,126,698 - 127,129,622 (+)Ensembl
GRCm3810127,290,793 - 127,296,291 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,290,774 - 127,296,288 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,290,829 - 127,293,753 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710126,727,849 - 126,733,344 (+)NCBIGRCm37mm9NCBIm37
MGSCv3610126,693,759 - 126,699,235 (+)NCBImm8
Celera10129,683,104 - 129,688,599 (+)NCBICelera
Cytogenetic Map10D3NCBI
Ddit3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2763,115,645 - 63,121,203 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl763,116,380 - 63,121,201 (+)Ensembl
Rnor_6.0770,578,564 - 70,585,074 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl770,580,198 - 70,585,084 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0770,753,800 - 70,759,220 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4767,247,749 - 67,252,571 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1767,268,487 - 67,273,294 (+)NCBI
Celera760,256,651 - 60,261,474 (+)NCBICelera
Cytogenetic Map7q22NCBI
Ddit3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554585,232,979 - 5,238,513 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554585,232,979 - 5,238,513 (-)NCBIChiLan1.0ChiLan1.0
DDIT3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11231,664,766 - 31,668,699 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1231,664,743 - 31,668,701 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01231,406,332 - 31,410,293 (+)NCBIMhudiblu_PPA_v0panPan3
Ddit3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494557,201,026 - 57,205,216 (+)NCBI
SpeTri2.0NW_0049366461,665,019 - 1,669,212 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DDIT3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl522,785,445 - 22,789,829 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1522,785,441 - 22,789,867 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
DDIT3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11153,424,693 - 53,429,094 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1153,424,868 - 53,425,576 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037192,535,088 - 192,539,471 (+)NCBIVero_WHO_p1.0
Ddit3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462480210,437,998 - 10,443,278 (+)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 4 17 1 5 1 3 11 8 10 1
Low 5 1 5 5 1 5 6 3 1 5
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005625542 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_014117187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022424097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038487894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038487895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038549788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038549789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038613750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038613751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038679110 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038679111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000047972   ⟹   ENSCAFP00000039330
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl101,606,693 - 1,611,303 (-)Ensembl
RefSeq Acc Id: ENSCAFT00845021502   ⟹   ENSCAFP00845016899
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl101,615,759 - 1,620,369 (-)Ensembl
RefSeq Acc Id: XM_014117187   ⟹   XP_013972662
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1101,606,693 - 1,611,378 (-)NCBI
Dog10K_Boxer_Tasha101,669,927 - 1,674,607 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022424097   ⟹   XP_022279805
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1101,606,693 - 1,612,410 (-)NCBI
Dog10K_Boxer_Tasha101,669,927 - 1,675,567 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038487894   ⟹   XP_038343822
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1101,593,774 - 1,598,449 (-)NCBI
RefSeq Acc Id: XM_038487895   ⟹   XP_038343823
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1101,593,774 - 1,599,407 (-)NCBI
RefSeq Acc Id: XM_038549788   ⟹   XP_038405716
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0101,960,652 - 1,965,332 (-)NCBI
RefSeq Acc Id: XM_038549789   ⟹   XP_038405717
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0101,960,652 - 1,966,292 (-)NCBI
RefSeq Acc Id: XM_038613750   ⟹   XP_038469678
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0101,835,463 - 1,840,337 (-)NCBI
RefSeq Acc Id: XM_038613751   ⟹   XP_038469679
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0101,835,463 - 1,841,297 (-)NCBI
RefSeq Acc Id: XM_038679110   ⟹   XP_038535038
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0101,615,759 - 1,620,439 (-)NCBI
RefSeq Acc Id: XM_038679111   ⟹   XP_038535039
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0101,615,759 - 1,621,400 (-)NCBI
Reference Sequences
RefSeq Acc Id: XP_013972662   ⟸   XM_014117187
- UniProtKB: J9P1A6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022279805   ⟸   XM_022424097
- Sequence:
RefSeq Acc Id: ENSCAFP00000039330   ⟸   ENSCAFT00000047972
RefSeq Acc Id: XP_038343823   ⟸   XM_038487895
RefSeq Acc Id: XP_038343822   ⟸   XM_038487894
RefSeq Acc Id: XP_038469679   ⟸   XM_038613751
RefSeq Acc Id: XP_038469678   ⟸   XM_038613750
RefSeq Acc Id: XP_038535039   ⟸   XM_038679111
RefSeq Acc Id: XP_038535038   ⟸   XM_038679110
RefSeq Acc Id: XP_038405717   ⟸   XM_038549789
RefSeq Acc Id: XP_038405716   ⟸   XM_038549788
RefSeq Acc Id: ENSCAFP00845016899   ⟸   ENSCAFT00845021502
Protein Domains
bZIP

Promoters
RGD ID:13684885
Promoter ID:EPDNEW_C2953
Type:single initiation site
Name:DDIT3_1
Description:DNA damage inducible transcript 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1101,608,655 - 1,608,715EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000030112 Ensembl
  ENSCAFG00030007751 UniProtKB/TrEMBL
  ENSCAFG00040014608 UniProtKB/TrEMBL
  ENSCAFG00845012093 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00030012426.1 UniProtKB/TrEMBL
  ENSCAFP00040023407 UniProtKB/TrEMBL
  ENSCAFP00845016899 ENTREZGENE
  ENSCAFP00845016899.1 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00030014253.1 UniProtKB/TrEMBL
  ENSCAFT00040026931 UniProtKB/TrEMBL
  ENSCAFT00845021502 ENTREZGENE
  ENSCAFT00845021502.1 UniProtKB/TrEMBL
InterPro bZIP UniProtKB/TrEMBL
  DNA_damage_induc_transcript_3 UniProtKB/TrEMBL
NCBI Gene DDIT3 ENTREZGENE
PANTHER PTHR16833 UniProtKB/TrEMBL
PIRSF C/EBPzeta_CHOP_DDIT3 UniProtKB/TrEMBL
PROSITE BZIP UniProtKB/TrEMBL
SMART BRLZ UniProtKB/TrEMBL
UniProt A0A8C0MS70_CANLF UniProtKB/TrEMBL
  A0A8I3NHJ0_CANLF UniProtKB/TrEMBL
  J9P1A6 ENTREZGENE
VGNC ID VGNC:39836 ENTREZGENE