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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69165
Species: Homo sapiens
RGD Object: Gene
Symbol: DDIT3
Name: DNA damage inducible transcript 3
Acc ID: CHEBI:65329
Term: LY294002
Definition: A chromone substituted with a phenyl group at position 8 and a morpholine group at position 2.
Chemical ID: MESH:C085911
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
DDIT3multiple interactionsEXP 6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of DDIT3 protein]PMID:17171638
DDIT3multiple interactionsISODdit3 (Rattus norvegicus)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium results in increased expression of DDIT3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Cadmium Chloride results in increased expression of DDIT3 protein]]PMID:27658547 PMID:31433112
DDIT3multiple interactionsISODdit3 (Mus musculus)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Hydrogen Peroxide results in increased expression of DDIT3 protein]PMID:11145585
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