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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69165
Species: Homo sapiens
RGD Object: Gene
Symbol: DDIT3
Name: DNA damage inducible transcript 3
Acc ID: CHEBI:46345
Term: 5-fluorouracil
Definition: A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Chemical ID: MESH:D005472
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
DDIT3increases expressionEXP 6480464CTDFluorouracil results in increased expression of DDIT3 mRNA; Fluorouracil results in increased expression of DDIT3 proteinPMID:17355264 PMID:29879413 PMID:32535746
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