DDIT3 (DNA damage inducible transcript 3) - Rat Genome Database

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Gene: DDIT3 (DNA damage inducible transcript 3) Sus scrofa
Analyze
Symbol: DDIT3
Name: DNA damage inducible transcript 3
RGD ID: 13843780
Description: ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription factor activity (ortholog); identical protein binding (ortholog); INVOLVED IN aging (ortholog); cell redox homeostasis (ortholog); cellular response to manganese ion (ortholog); ASSOCIATED WITH acute kidney failure (ortholog); Acute Lung Injury (ortholog); Acute-Phase Reaction (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog); RNA polymerase II transcription regulator complex (ortholog); INTERACTS WITH cadmium dichloride; indometacin; linsidomine
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: CHOP; DNA damage-inducible transcript 3 protein
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl522,785,441 - 22,791,134 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1522,785,441 - 22,789,867 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
anterior/posterior axis specification  (IEA)
apoptotic process  (IEA)
blood vessel maturation  (IEA)
cell redox homeostasis  (ISO)
cellular response to manganese ion  (ISO)
embryonic organ development  (ISO)
endoplasmic reticulum unfolded protein response  (IEA,ISO)
ER overload response  (IBA,ISO)
establishment of protein localization to mitochondrion  (IEA)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (IBA,ISO)
intrinsic apoptotic signaling pathway in response to nitrosative stress  (IEA)
luteolysis  (ISO)
negative regulation of canonical Wnt signaling pathway  (IEA)
negative regulation of cold-induced thermogenesis  (IEA)
negative regulation of CREB transcription factor activity  (IBA,ISO)
negative regulation of determination of dorsal identity  (IEA)
negative regulation of DNA binding  (ISO)
negative regulation of DNA-binding transcription factor activity  (ISO)
negative regulation of fat cell differentiation  (IEA,ISO)
negative regulation of interferon-gamma production  (IEA,ISO)
negative regulation of interleukin-17 production  (IEA,ISO)
negative regulation of interleukin-4 production  (IEA,ISO)
negative regulation of myoblast differentiation  (IEA)
negative regulation of NF-kappaB transcription factor activity  (IEA,ISO)
negative regulation of protein kinase B signaling  (IEA)
negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding  (IEA)
negative regulation of transcription by RNA polymerase II  (IBA)
negative regulation of transcription, DNA-templated  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of autophagy in response to ER overload  (ISO)
positive regulation of DNA-binding transcription factor activity  (IEA)
positive regulation of interleukin-8 production  (IEA)
positive regulation of intrinsic apoptotic signaling pathway  (IBA)
positive regulation of neuron apoptotic process  (IEA)
positive regulation of neuron death  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  (IBA)
positive regulation of transcription, DNA-templated  (ISO)
proteasome-mediated ubiquitin-dependent protein catabolic process  (IEA)
regulation of autophagy  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
regulation of transcription, DNA-templated  (IEA,ISO)
release of sequestered calcium ion into cytosol  (IEA)
response to amphetamine  (ISO)
response to drug  (ISO)
response to endoplasmic reticulum stress  (ISO)
response to hydrogen peroxide  (ISO)
response to nutrient  (ISO)
response to oxidative stress  (ISO)
response to starvation  (IEA)
response to toxic substance  (ISO)
response to unfolded protein  (ISO)
sensory perception of sound  (IEA,ISO)

Cellular Component

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:28566374  


Genomics

Comparative Map Data
DDIT3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl522,785,441 - 22,791,134 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1522,785,441 - 22,789,867 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
DDIT3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1257,516,588 - 57,521,737 (-)EnsemblGRCh38hg38GRCh38
GRCh381257,516,588 - 57,520,517 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371257,910,371 - 57,914,300 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361256,196,638 - 56,200,567 (-)NCBINCBI36hg18NCBI36
Build 341256,196,639 - 56,200,567NCBI
Celera1257,566,204 - 57,570,133 (-)NCBI
Cytogenetic Map12q13.3NCBI
HuRef1254,948,369 - 54,952,298 (-)NCBIHuRef
CHM1_11257,878,226 - 57,882,156 (-)NCBICHM1_1
Ddit3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910127,126,662 - 127,132,160 (+)NCBIGRCm39mm39
GRCm39 Ensembl10127,126,643 - 127,132,157 (+)Ensembl
GRCm39 Ensembl10127,126,698 - 127,129,622 (+)Ensembl
GRCm3810127,290,793 - 127,296,291 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,290,774 - 127,296,288 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl10127,290,829 - 127,293,753 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710126,727,849 - 126,733,344 (+)NCBIGRCm37mm9NCBIm37
MGSCv3610126,693,759 - 126,699,235 (+)NCBImm8
Celera10129,683,104 - 129,688,599 (+)NCBICelera
Cytogenetic Map10D3NCBI
Ddit3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2763,115,645 - 63,121,203 (+)NCBI
Rnor_6.0 Ensembl770,580,198 - 70,585,084 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0770,578,564 - 70,585,074 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0770,753,800 - 70,759,220 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4767,247,749 - 67,252,571 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1767,268,487 - 67,273,294 (+)NCBI
Celera760,256,651 - 60,261,474 (+)NCBICelera
Cytogenetic Map7q22NCBI
Ddit3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554585,232,979 - 5,238,513 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554585,232,979 - 5,238,513 (-)NCBIChiLan1.0ChiLan1.0
DDIT3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11231,664,766 - 31,668,699 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1231,664,743 - 31,668,701 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01231,406,332 - 31,410,293 (+)NCBIMhudiblu_PPA_v0panPan3
DDIT3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1101,606,693 - 1,612,410 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl101,606,693 - 1,611,303 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha101,669,927 - 1,675,567 (-)NCBI
ROS_Cfam_1.0101,615,759 - 1,621,400 (-)NCBI
UMICH_Zoey_3.1101,593,774 - 1,599,407 (-)NCBI
UNSW_CanFamBas_1.0101,835,463 - 1,841,297 (-)NCBI
UU_Cfam_GSD_1.0101,960,652 - 1,966,292 (-)NCBI
Ddit3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494557,201,026 - 57,205,216 (+)NCBI
SpeTri2.0NW_0049366461,665,019 - 1,669,212 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DDIT3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11153,424,693 - 53,429,094 (-)NCBI
ChlSab1.1 Ensembl1153,424,868 - 53,425,576 (-)Ensembl
Ddit3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462480210,437,998 - 10,443,278 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000059228   ⟹   ENSSSCP00000044365
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl522,785,441 - 22,791,134 (-)Ensembl
RefSeq Acc Id: ENSSSCT00000087660   ⟹   ENSSSCP00000063593
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl522,785,593 - 22,789,037 (-)Ensembl
RefSeq Acc Id: NM_001144845   ⟹   NP_001138317
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1522,785,582 - 22,787,017 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005674378   ⟹   XP_005674435
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1522,785,441 - 22,789,867 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001138317 (Get FASTA)   NCBI Sequence Viewer  
  XP_005674435 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABY58644 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005674435   ⟸   XM_005674378
- Peptide Label: isoform X1
- UniProtKB: B8Q504 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001138317   ⟸   NM_001144845
- UniProtKB: B8Q504 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000044365   ⟸   ENSSSCT00000059228
RefSeq Acc Id: ENSSSCP00000063593   ⟸   ENSSSCT00000087660
Protein Domains
bZIP


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000044553 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00070029105 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000044365 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000063593 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00070049649 UniProtKB/TrEMBL
  ENSSSCP00070049650 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000059228 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000087660 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00070058387 UniProtKB/TrEMBL
  ENSSSCT00070058388 UniProtKB/TrEMBL
InterPro bZIP UniProtKB/TrEMBL
  DNA_damage_induc_transcript_3 UniProtKB/TrEMBL
KEGG Report ssc:100240743 UniProtKB/TrEMBL
NCBI Gene DDIT3 ENTREZGENE
PANTHER PTHR16833 UniProtKB/TrEMBL
PIRSF C/EBPzeta_CHOP_DDIT3 UniProtKB/TrEMBL
PROSITE BZIP UniProtKB/TrEMBL
SMART BRLZ UniProtKB/TrEMBL
UniProt A0A4X1W673_PIG UniProtKB/TrEMBL
  A0A5G2QND8_PIG UniProtKB/TrEMBL
  B8Q504 ENTREZGENE, UniProtKB/TrEMBL