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Gene: APLN (apelin) Homo sapiens
Symbol: APLN
Name: apelin
Description: Exhibits apelin receptor binding activity and hormone activity. Involved in several processes, including negative regulation of vascular smooth muscle cell proliferation; positive regulation of macromolecule metabolic process; and positive regulation of vascular endothelial cell proliferation. Localizes to the extracellular region. Biomarker of several diseases, including Crohn's disease; artery disease (multiple); atrial fibrillation; morbid obesity; and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AGTRL1 ligand; APEL; APJ endogenous ligand; XNPEP2
Mus musculus (house mouse) : Apln (apelin)  MGI  Alliance
Rattus norvegicus (Norway rat) : Apln (apelin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Apln (apelin)
Pan paniscus (bonobo/pygmy chimpanzee) : APLN (apelin)
Canis lupus familiaris (dog) : APLN (apelin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Apln (apelin)
Sus scrofa (pig) : APLN (apelin)
Chlorocebus sabaeus (green monkey) : APLN (apelin)
Heterocephalus glaber (naked mole-rat) : Apln (apelin)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 EnsemblX129,645,259 - 129,654,956 (-)Ensembl
GRCh38X129,645,259 - 129,654,956 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X128,779,236 - 128,788,933 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X128,607,006 - 128,616,595 (-)NCBINCBI36hg18NCBI36
Build 34X128,504,860 - 128,514,449NCBI
CeleraX129,165,798 - 129,175,495 (-)NCBI
Cytogenetic MapXq26.1NCBI
HuRefX118,183,705 - 118,187,243 (-)NCBIHuRef
CHM1_1X128,690,603 - 128,700,300 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on APLN
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1351986
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.