CYP2C19 (cytochrome P450 family 2 subfamily C member 19) - Rat Genome Database

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Gene: CYP2C19 (cytochrome P450 family 2 subfamily C member 19) Homo sapiens
Analyze
Symbol: CYP2C19
Name: cytochrome P450 family 2 subfamily C member 19
RGD ID: 737416
HGNC Page HGNC
Description: Enables enzyme binding activity; heme binding activity; and steroid hydroxylase activity. Involved in several processes, including monoterpenoid metabolic process; steroid metabolic process; and xenobiotic catabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Implicated in several diseases, including Plasmodium falciparum malaria; eosinophilic esophagitis; invasive aspergillosis; multiple chemical sensitivity; and sickle cell anemia. Biomarker of Keshan disease and dilated cardiomyopathy.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CPCJ; CYP2C; CYPIIC17; CYPIIC19; cytochrome P-450 II C; cytochrome P450 2C19; cytochrome P450, family 2, subfamily C, polypeptide 19; cytochrome p450, subfamily iic (mephenytoin 4-hydroxylase); cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 19; cytochrome P450-11A; cytochrome P450-254C; fenbendazole monooxygenase (4'-hydroxylating); flavoprotein-linked monooxygenase; mephenytoin 4'-hydroxylase; mephenytoin 4-hydroxylase; microsomal monooxygenase; P450C2C; P450IIC19; S-mephenytoin 4-hydroxylase; xenobiotic monooxygenase
RGD Orthologs
Mouse
Rat
Bonobo
Pig
Green Monkey
Alliance Genes
More Info more info ...
Related Pseudogenes: CYP2C63P   CYP2C64P  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1094,762,681 - 94,855,547 (+)EnsemblGRCh38hg38GRCh38
GRCh381094,762,681 - 94,855,547 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371096,522,438 - 96,615,304 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361096,512,453 - 96,602,661 (+)NCBINCBI36hg18NCBI36
Build 341096,512,452 - 96,602,661NCBI
Celera1090,262,555 - 90,352,777 (+)NCBI
Cytogenetic Map10q23.33NCBI
HuRef1090,149,122 - 90,239,340 (+)NCBIHuRef
CHM1_11096,804,212 - 96,894,435 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (EXP)
(+)-schisandrin B  (ISO)
(3-phenoxyphenyl)methanol  (EXP)
(E)-thiamethoxam  (EXP)
(E,E)-germacrone  (EXP)
(R)-lipoic acid  (EXP)
(S)-naringenin  (EXP)
1,1,1-Trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane  (EXP)
1,2-dichloroethane  (ISO)
1,2-dichloroethene  (ISO)
1,4-naphthoquinone  (EXP)
1-(1,3-benzodioxol-5-yl)-4,4-dimethyl-1-penten-3-ol  (EXP)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (EXP)
1-naphthol  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-[cyclohexyl(oxo)methyl]-3,6,7,11b-tetrahydro-1H-pyrazino[2,1-a]isoquinolin-4-one  (EXP)
2-nitroanisole  (EXP,ISO)
2-tert-butylhydroquinone  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,5,6-trichloro-2-pyridinol  (EXP)
3,5,6-trichloropyridine-2-one  (EXP)
3,5-xylenol  (EXP)
4-(methylsulfinyl)phenol  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-bromo-2-chlorophenol  (EXP)
4-hydroxychalcone  (ISO)
4-hydroxycyclophosphamide  (EXP)
4-hydroxytolbutamide  (EXP)
4-Ipomeanol  (EXP)
4-nitrophenol  (EXP)
4-tert-Octylphenol  (EXP)
5-hydroxydiclofenac  (EXP)
5-Hydroxythalidomide  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
5-methoxy-N,N-diisopropyltryptamine  (EXP)
7,12-dimethyltetraphene  (EXP)
7-hydroxyflavone  (EXP)
acenocoumarol  (EXP)
acetamide  (ISO)
aconitine  (EXP)
acrolein  (EXP)
adinazolam  (EXP)
ADP  (EXP)
afimoxifene  (EXP)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (EXP,ISO)
almotriptan  (EXP)
alpha-hexachlorocyclohexane  (ISO)
alpha-linolenic acid  (EXP)
alpha-methyltryptamine  (EXP)
amiodarone  (EXP)
amitriptyline  (EXP)
amitriptylinoxide  (EXP)
ammonium chloride  (ISO)
amodiaquine  (EXP)
amphetamine  (EXP)
arachidonic acid  (EXP)
aristolochic acid  (ISO)
Aroclor 1254  (EXP,ISO)
Asiaticoside  (EXP)
atrazine  (EXP)
Avasimibe  (EXP)
azoxystrobin  (EXP)
baicalein  (EXP)
barnidipine  (EXP)
benfuracarb  (EXP)
benidipine  (EXP)
benzbromarone  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzylideneacetone  (ISO)
beta-hexachlorocyclohexane  (ISO)
beta-naphthoflavone  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bortezomib  (EXP)
bromfenac  (EXP)
Bufuralol  (EXP,ISO)
bupropion  (EXP)
cadmium dichloride  (ISO)
calcitriol  (EXP)
cannabidiol  (EXP)
capsaicin  (EXP)
captan  (EXP,ISO)
carbamazepine  (EXP)
carbendazim  (EXP)
carbofuran  (EXP)
carisoprodol  (EXP)
chalcone  (ISO)
chelidonine  (EXP)
chloramphenicol  (EXP)
chlorohydrocarbon  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (EXP)
chlorzoxazone  (ISO)
choline  (ISO)
chrysosplenetin  (EXP)
citalopram  (EXP)
Citreorosein  (EXP)
clopidogrel  (EXP)
clotrimazole  (ISO)
clozapine  (EXP)
Clozapine N-oxide  (EXP)
copper(II) chloride  (ISO)
cumene hydroperoxide  (EXP)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP)
cypermethrin  (EXP)
cyproconazole  (EXP,ISO)
cyprodinil  (EXP)
dapsone  (EXP)
decabromodiphenyl ether  (ISO)
dehydroepiandrosterone sulfate  (ISO)
delavirdine  (EXP)
deoxycholic acid  (ISO)
desipramine  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dextromethorphan  (EXP)
diarylheptanoid  (EXP)
diazepam  (EXP,ISO)
diazinon  (EXP)
dibenzo[a,l]pyrene  (EXP)
dichloroacetic acid  (ISO)
diclofenac  (EXP,ISO)
diethylcarbamazine  (EXP)
diethyldithiocarbamic acid  (EXP)
difenoconazole  (EXP)
dihydroartemisinin  (EXP)
dihydrocapsaicin  (EXP)
dimemorfan  (EXP)
dimethomorph  (EXP)
dimethyl sulfoxide  (ISO)
diniconazole  (EXP)
diosmetin  (EXP)
dronedarone  (EXP)
efavirenz  (EXP)
Elemicin  (EXP)
ellipticine  (EXP)
emodin  (EXP)
endosulfan  (ISO)
enfuvirtide  (EXP)
enilconazole  (EXP)
epoxiconazole  (EXP,ISO)
ethambutol  (EXP)
ethanol  (ISO)
ethofumesate  (EXP)
ethoprophos  (EXP)
eupatorin  (EXP)
famotidine  (EXP)
fenhexamid  (EXP)
fenofibrate  (EXP)
fenpyroximate  (EXP)
fenvalerate  (EXP)
fipronil  (EXP)
fluconazole  (EXP)
fludioxonil  (EXP)
flunitrazepam  (EXP)
fluorescein (lactone form)  (EXP)
fluoxetine  (EXP,ISO)
fluphenazine  (EXP)
flusilazole  (EXP)
flutamide  (EXP)
fluxapyroxad  (EXP)
folic acid  (ISO)
Furafylline  (EXP,ISO)
furan  (ISO)
genistein  (EXP,ISO)
gingerol  (EXP)
glutathione  (EXP)
glyoxal  (EXP)
herbicide  (EXP)
hesperetin  (EXP)
hexobarbital  (EXP)
Hydroxymephenytoin  (EXP)
Hypaconitine  (EXP)
ifosfamide  (EXP)
imipramine  (EXP)
imipramine oxide  (EXP)
imiquimod  (EXP)
indole-3-methanol  (ISO)
iprodione  (EXP)
isocarbophos  (EXP)
isoliquiritigenin  (EXP)
ketoconazole  (EXP,ISO)
L-methionine  (ISO)
lamotrigine  (ISO)
lansoprazole  (EXP,ISO)
lefetamine  (EXP)
Licochalcone A  (EXP)
linoleic acid  (EXP)
lipoic acid  (EXP)
liquiritigenin  (EXP)
lithocholic acid  (ISO)
luteolin  (EXP)
madecassoside  (EXP)
maneb  (EXP)
mangiferin  (ISO)
mefenamic acid  (EXP)
Melarsoprol  (EXP)
melatonin  (EXP)
mephenytoin  (EXP)
mephobarbital  (EXP)
Meprobamate  (EXP)
mercury dichloride  (ISO)
metalaxyl  (EXP)
methiocarb  (EXP)
methiocarb-sulfoxide  (EXP)
methoxsalen  (ISO)
methoxychlor  (EXP)
methylmercury chloride  (ISO)
Methysticin  (ISO)
metolachlor  (EXP)
miconazole  (EXP)
Miltirone  (EXP)
Mitragynine  (EXP)
moclobemide  (EXP)
mono(2-ethyl-5-hydroxyhexyl) phthalate  (EXP,ISO)
mono(2-ethyl-5-oxohexyl) phthalate  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monocrotaline  (EXP)
myricetin  (EXP)
N,N-diethyl-m-toluamide  (EXP,ISO)
N,N-diisopropyltryptamine  (EXP)
N,N-dimethyltryptamine  (EXP)
N-acetyl-L-cysteine  (EXP)
N-desmethylclozapine  (EXP)
N-hydroxy-PhIP  (EXP)
N-nitrosodiethylamine  (ISO)
NADP zwitterion  (EXP)
NADP(+)  (EXP)
naphthalene  (EXP)
Nicardipine  (EXP)
nimesulide  (EXP)
norflurazon  (EXP)
norgestimate  (EXP)
Notopterol  (EXP)
O-methyleugenol  (EXP)
okanin  (EXP)
omeprazole  (EXP)
organophosphorus compound  (EXP)
orotic acid  (ISO)
oxymetazoline  (EXP)
p-tert-Amylphenol  (EXP)
pantoprazole  (EXP)
paracetamol  (EXP)
paraquat  (ISO)
parathion  (EXP)
PCB138  (ISO)
pedalitin  (EXP)
pentamidine  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (EXP,ISO)
phenacetin  (ISO)
phencyclidine  (EXP)
phenobarbital  (EXP,ISO)
phenytoin  (EXP,ISO)
PhIP  (EXP)
phthalic acid  (ISO)
physcion  (EXP)
picoxystrobin  (EXP)
pirinixic acid  (ISO)
poly(I:C)  (ISO)
pomalidomide  (EXP)
prednisolone  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
prochloraz  (EXP)
profenofos  (EXP)
progesterone  (EXP)
proguanil  (EXP)
propiconazole  (EXP)
propranolol  (EXP)
pterostilbene  (EXP)
pyrene  (ISO)
pyrrolidines  (EXP)
quercetin  (EXP)
quinidine  (EXP,ISO)
quinine  (EXP,ISO)
rabeprazole  (EXP)
resveratrol  (EXP,ISO)
Retrorsine  (EXP)
rifampicin  (EXP)
ritonavir  (EXP)
sertraline  (EXP)
sibutramine  (EXP)
sodium arsenite  (EXP,ISO)
sophoranone  (EXP)
Sudan I  (EXP)
sulfaphenazole  (EXP,ISO)
sulfasalazine  (ISO)
suramin  (EXP)
tacrolimus hydrate  (EXP)
tamoxifen  (EXP)
Tanshinone I  (EXP)
tert-butyl ethyl ether  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetraconazole  (EXP)
tetracycline  (ISO)
thalidomide  (EXP)
thiacloprid  (EXP)
thiamethoxam  (EXP)
thioacetamide  (ISO)
thioridazine  (EXP)
thiram  (EXP)
ticlopidine  (EXP)
titanium dioxide  (ISO)
tofacitinib  (EXP)
tolbutamide  (EXP)
toluene  (ISO)
trans-1,2-dichloroethene  (ISO)
trans-chalcone  (ISO)
trans-cinnamic acid  (EXP)
tranylcypromine  (EXP)
triclosan  (EXP)
triflumuron  (EXP)
troglitazone  (EXP)
tryptamines  (EXP)
ursodeoxycholic acid  (ISO)
ursolic acid  (EXP)
valdecoxib  (ISO)
valproic acid  (EXP,ISO)
vanoxerine dihydrochloride  (EXP)
veliparib  (EXP)
venlafaxine hydrochloride  (EXP)
voriconazole  (EXP)
warfarin  (EXP)
zafirlukast  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
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8. GOA_HUMAN data from the GO Consortium
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11. Kaneko A, etal., Pharmacogenetics. 1999 Jun;9(3):317-26.
12. KEGG
13. Kim SH, etal., Eur J Clin Pharmacol. 2011 Feb;67(2):121-7. doi: 10.1007/s00228-010-0912-4. Epub 2010 Oct 13.
14. Kim SY, etal., Chem Res Toxicol. 2003 Sep;16(9):1138-44.
15. Li Y, etal., Haematologica. 2007 Sep;92(9):1246-9. Epub 2007 Aug 1.
16. Lim JS, etal., Br J Clin Pharmacol. 2016 Jun;81(6):1142-52. doi: 10.1111/bcp.12886. Epub 2016 Mar 8.
17. Manuyakorn W, etal., Pediatr Allergy Immunol. 2013 May;24(3):299-303. doi: 10.1111/pai.12058. Epub 2013 Apr 3.
18. Melanson SE, etal., Am J Hematol. 2010 Dec;85(12):967-71. doi: 10.1002/ajh.21889.
19. Molina-Infante J, etal., Am J Gastroenterol. 2015 Nov;110(11):1567-75. doi: 10.1038/ajg.2015.314. Epub 2015 Sep 29.
20. Musumba CO, etal., Clin Pharmacol Ther. 2013 Feb;93(2):195-203. doi: 10.1038/clpt.2012.215. Epub 2012 Oct 26.
21. Nabinger DD, etal., Genet Mol Res. 2016 Sep 16;15(3). pii: gmr8734. doi: 10.4238/gmr.15038734.
22. Neyshaburinezhad N, etal., Iran J Basic Med Sci. 2020 May;23(5):629-635. doi: 10.22038/ijbms.2020.40836.9642.
23. OMIM Disease Annotation Pipeline
24. Pipeline to import KEGG annotations from KEGG into RGD
25. Pipeline to import SMPDB annotations from SMPDB into RGD
26. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
27. RGD automated import pipeline for gene-chemical interactions
28. RGD automated import pipeline for human HPO-to-gene-to-disease annotations
29. Shaik AN, etal., J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jan 1;1008:164-73. doi: 10.1016/j.jchromb.2015.11.036. Epub 2015 Nov 23.
30. Sheu BS, etal., Aliment Pharmacol Ther. 2005 Feb 1;21(3):283-8. doi: 10.1111/j.1365-2036.2005.02281.x.
31. Vangsted AJ, etal., BMC Cancer. 2010 Aug 4;10:404. doi: 10.1186/1471-2407-10-404.
32. Wang T, etal., Int J Antimicrob Agents. 2014 Nov;44(5):436-42. doi: 10.1016/j.ijantimicag.2014.07.013. Epub 2014 Aug 30.
33. Xavier AS, etal., Fundam Clin Pharmacol. 2016 Dec;30(6):607-615. doi: 10.1111/fcp.12218. Epub 2016 Jul 26.
34. Zandvliet AS, etal., Clin Cancer Res. 2007 May 15;13(10):2970-6.
35. Zhou B, etal., Biomed Rep. 2016 Feb;4(2):251-255. doi: 10.3892/br.2015.563. Epub 2015 Dec 31.
Additional References at PubMed
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PMID:14583683   PMID:14616425   PMID:14634042   PMID:14634838   PMID:14636465   PMID:14653835   PMID:14659971   PMID:14695703   PMID:14990013   PMID:14998561   PMID:15017629   PMID:15025747  
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PMID:16789993   PMID:16812949   PMID:16815315   PMID:16815316   PMID:16855453   PMID:16862439   PMID:16863547   PMID:16873909   PMID:16890574   PMID:16890578   PMID:16908943   PMID:16911688  
PMID:16912869   PMID:16924387   PMID:16937451   PMID:16946555   PMID:16960452   PMID:17003844   PMID:17047431   PMID:17047492   PMID:17048007   PMID:17052843   PMID:17112810   PMID:17178267  
PMID:17201743   PMID:17203292   PMID:17215846   PMID:17269966   PMID:17279092   PMID:17290075   PMID:17295875   PMID:17298483   PMID:17304159   PMID:17357148   PMID:17358097   PMID:17377957  
PMID:17407229   PMID:17410461   PMID:17417917   PMID:17418993   PMID:17424941   PMID:17433262   PMID:17439410   PMID:17450472   PMID:17455109   PMID:17487889   PMID:17502835   PMID:17559380  
PMID:17562299   PMID:17623107   PMID:17625515   PMID:17635176   PMID:17635181   PMID:17667801   PMID:17667959   PMID:17680025   PMID:17681590   PMID:17697139   PMID:17697203   PMID:17827141  
PMID:17868191   PMID:17875119   PMID:17900275   PMID:17909762   PMID:17922881   PMID:17924835   PMID:17934830   PMID:17966194   PMID:17978853   PMID:17992535   PMID:18004210   PMID:18021343  
PMID:18024866   PMID:18057705   PMID:18061941   PMID:18154472   PMID:18205890   PMID:18211619   PMID:18214455   PMID:18223462   PMID:18224311   PMID:18231117   PMID:18240903   PMID:18240905  
PMID:18241283   PMID:18241287   PMID:18294333   PMID:18312490   PMID:18319058   PMID:18323861   PMID:18346178   PMID:18356043   PMID:18382661   PMID:18394438   PMID:18399167   PMID:18423013  
PMID:18425152   PMID:18466100   PMID:18482659   PMID:18496131   PMID:18496682   PMID:18510611   PMID:18511451   PMID:18518848   PMID:18520596   PMID:18520598   PMID:18521743   PMID:18532997  
PMID:18551037   PMID:18577829   PMID:18581106   PMID:18637061   PMID:18641551   PMID:18644391   PMID:18654768   PMID:18676680   PMID:18677622   PMID:18702650   PMID:18751689   PMID:18765869  
PMID:18781853   PMID:18823430   PMID:18854779   PMID:18854824   PMID:18936436   PMID:18957504   PMID:18979093   PMID:18982321   PMID:18996102   PMID:19002442   PMID:19025845   PMID:19029318  
PMID:19033450   PMID:19038035   PMID:19069365   PMID:19074885   PMID:19102714   PMID:19106083   PMID:19106084   PMID:19108880   PMID:19129087   PMID:19136640   PMID:19139162   PMID:19151603  
PMID:19156902   PMID:19164093   PMID:19166419   PMID:19169185   PMID:19170196   PMID:19172254   PMID:19176055   PMID:19192051   PMID:19193675   PMID:19193970   PMID:19199010   PMID:19219744  
PMID:19220726   PMID:19236548   PMID:19238367   PMID:19246508   PMID:19259653   PMID:19261446   PMID:19268736   PMID:19290787   PMID:19299322   PMID:19336370   PMID:19337788   PMID:19343046  
PMID:19348299   PMID:19350405   PMID:19398604   PMID:19404631   PMID:19407662   PMID:19414633   PMID:19415745   PMID:19415824   PMID:19424794   PMID:19429918   PMID:19430176   PMID:19474452  
PMID:19496924   PMID:19499406   PMID:19516253   PMID:19531897   PMID:19534586   PMID:19546880   PMID:19552744   PMID:19576320   PMID:19578179   PMID:19583677   PMID:19593158   PMID:19593168  
PMID:19617466   PMID:19621685   PMID:19624462   PMID:19625176   PMID:19636337   PMID:19638460   PMID:19651758   PMID:19661214   PMID:19692168   PMID:19693007   PMID:19696793   PMID:19702490  
PMID:19706858   PMID:19712984   PMID:19745563   PMID:19751749   PMID:19761366   PMID:19773541   PMID:19817997   PMID:19821196   PMID:19823875   PMID:19840783   PMID:19841156   PMID:19847408  
PMID:19881258   PMID:19884907   PMID:19890215   PMID:19891553   PMID:19904250   PMID:19907421   PMID:19926050   PMID:19928008   PMID:19932784   PMID:19933691   PMID:19934793   PMID:19940233  
PMID:19942749   PMID:19954515   PMID:19954746   PMID:19956635   PMID:19961004   PMID:19968574   PMID:20002085   PMID:20015960   PMID:20040040   PMID:20064729   PMID:20078610   PMID:20083681  
PMID:20088379   PMID:20113968   PMID:20147896   PMID:20163283   PMID:20173083   PMID:20179710   PMID:20206639   PMID:20207952   PMID:20223877   PMID:20235787   PMID:20236133   PMID:20297661  
PMID:20309015   PMID:20349052   PMID:20350051   PMID:20350136   PMID:20351750   PMID:20356512   PMID:20358205   PMID:20360782   PMID:20373852   PMID:20376628   PMID:20390258   PMID:20414645  
PMID:20430047   PMID:20457439   PMID:20460345   PMID:20468063   PMID:20492431   PMID:20492467   PMID:20492469   PMID:20499227   PMID:20510210   PMID:20528170   PMID:20529763   PMID:20531370  
PMID:20533108   PMID:20549256   PMID:20549497   PMID:20559522   PMID:20565970   PMID:20573087   PMID:20581929   PMID:20602612   PMID:20602615   PMID:20620727   PMID:20633187   PMID:20637959  
PMID:20650435   PMID:20665013   PMID:20669013   PMID:20673183   PMID:20679960   PMID:20708365   PMID:20716239   PMID:20716514   PMID:20724801   PMID:20801494   PMID:20801498   PMID:20804307  
PMID:20823393   PMID:20826260   PMID:20831535   PMID:20831536   PMID:20833683   PMID:20838991   PMID:20845077   PMID:20845310   PMID:20857895   PMID:20863179   PMID:20885015   PMID:20890775  
PMID:20924183   PMID:20926021   PMID:20965456   PMID:20970553   PMID:20976881   PMID:20978260   PMID:20979470   PMID:21038076   PMID:21047200   PMID:21054462   PMID:21054464   PMID:21071160  
PMID:21075428   PMID:21079055   PMID:21099121   PMID:21108610   PMID:21132257   PMID:21152987   PMID:21160212   PMID:21173785   PMID:21192344   PMID:21212520   PMID:21215696   PMID:21237322  
PMID:21247447   PMID:21299635   PMID:21302482   PMID:21315147   PMID:21332417   PMID:21358751   PMID:21380557   PMID:21383338   PMID:21473286   PMID:21497341   PMID:21507170   PMID:21511217  
PMID:21511219   PMID:21527445   PMID:21627593   PMID:21628721   PMID:21689142   PMID:21692828   PMID:21741706   PMID:21766908   PMID:21777277   PMID:21778720   PMID:21786436   PMID:21794898  
PMID:21795468   PMID:21798861   PMID:21803320   PMID:21806387   PMID:21826689   PMID:21831410   PMID:21861665   PMID:21862109   PMID:21873635   PMID:21887904   PMID:21913914   PMID:21913948  
PMID:21916910   PMID:21971440   PMID:21972404   PMID:21977947   PMID:22007612   PMID:22028352   PMID:22030270   PMID:22045970   PMID:22070512   PMID:22071359   PMID:22088240   PMID:22116003  
PMID:22118006   PMID:22122271   PMID:22123356   PMID:22154242   PMID:22180071   PMID:22183943   PMID:22228204   PMID:22281205   PMID:22304323   PMID:22318618   PMID:22324425   PMID:22374717  
PMID:22377481   PMID:22418828   PMID:22425806   PMID:22450429   PMID:22469723   PMID:22476388   PMID:22491019   PMID:22552318   PMID:22585284   PMID:22589111   PMID:22591668   PMID:22612904  
PMID:22624833   PMID:22641027   PMID:22648560   PMID:22704413   PMID:22747643   PMID:22784880   PMID:22785462   PMID:22839512   PMID:22855348   PMID:22873740   PMID:22875498   PMID:22875511  
PMID:22913530   PMID:22929815   PMID:22940005   PMID:22955794   PMID:22971905   PMID:22974728   PMID:22984423   PMID:23001453   PMID:23016454   PMID:23074110   PMID:23081704   PMID:23118231  
PMID:23148634   PMID:23175667   PMID:23179471   PMID:23193974   PMID:23257377   PMID:23337798   PMID:23340030   PMID:23364775   PMID:23402725   PMID:23412869   PMID:23413279   PMID:23429358  
PMID:23469989   PMID:23470885   PMID:23474843   PMID:23506580   PMID:23517020   PMID:23555019   PMID:23556336   PMID:23588332   PMID:23607088   PMID:23618682   PMID:23623526   PMID:23629159  
PMID:23640828   PMID:23645039   PMID:23646118   PMID:23700873   PMID:23736997   PMID:23754447   PMID:23755828   PMID:23785064   PMID:23793025   PMID:23834474   PMID:23850044   PMID:23850318  
PMID:23872648   PMID:23874401   PMID:23877834   PMID:23886632   PMID:23895809   PMID:23941071   PMID:23951298   PMID:23959307   PMID:23981380   PMID:24015291   PMID:24016178   PMID:24019397  
PMID:24022708   PMID:24080149   PMID:24080325   PMID:24088005   PMID:24088578   PMID:24089073   PMID:24113215   PMID:24151801   PMID:24169346   PMID:24214141   PMID:24222221   PMID:24257813  
PMID:24279856   PMID:24315317   PMID:24330577   PMID:24338437   PMID:24340040   PMID:24345815   PMID:24346747   PMID:24402637   PMID:24403552   PMID:24430292   PMID:24440142   PMID:24443221  
PMID:24488700   PMID:24492587   PMID:24501942   PMID:24504666   PMID:24510350   PMID:24519754   PMID:24527758   PMID:24528284   PMID:24535487   PMID:24576527   PMID:24581091   PMID:24589079  
PMID:24599773   PMID:24608794   PMID:24617511   PMID:24690327   PMID:24710841   PMID:24723553   PMID:24761684   PMID:24762860   PMID:24781308   PMID:24782221   PMID:24796765   PMID:24798722  
PMID:24816252   PMID:24819914   PMID:24821368   PMID:24858822   PMID:24877854   PMID:24906606   PMID:24945780   PMID:24946154   PMID:24952855   PMID:24956245   PMID:24956251   PMID:24996380  
PMID:24996381   PMID:25001880   PMID:25001882   PMID:25008027   PMID:25030528   PMID:25043069   PMID:25044100   PMID:25060201   PMID:25061471   PMID:25068772   PMID:25073096   PMID:25077812  
PMID:25084200   PMID:25106522   PMID:25109411   PMID:25113522   PMID:25121365   PMID:25141895   PMID:25154506   PMID:25155930   PMID:25156215   PMID:25201060   PMID:25207801   PMID:25241292  
PMID:25245581   PMID:25258374   PMID:25264752   PMID:25286744   PMID:25303292   PMID:25323806   PMID:25339025   PMID:25381554   PMID:25403437   PMID:25428337   PMID:25463363   PMID:25465810  
PMID:25466287   PMID:25495406   PMID:25495411   PMID:25498969   PMID:25511576   PMID:25518510   PMID:25518511   PMID:25529343   PMID:25542807   PMID:25552922   PMID:25600201   PMID:25652102  
PMID:25686762   PMID:25712182   PMID:25730082   PMID:25803758   PMID:25823779   PMID:25838219   PMID:25844821   PMID:25845826   PMID:25846871   PMID:25877345   PMID:25897911   PMID:25921128  
PMID:25927305   PMID:25946232   PMID:25953735   PMID:25993709   PMID:25995169   PMID:25999694   PMID:26021325   PMID:26062298   PMID:26071289   PMID:26117917   PMID:26126958   PMID:26147597  
PMID:26153442   PMID:26218263   PMID:26223287   PMID:26239045   PMID:26239729   PMID:26244421   PMID:26264906   PMID:26265611   PMID:26272232   PMID:26296572   PMID:26298540   PMID:26313485  
PMID:26323597   PMID:26331711   PMID:26338921   PMID:26343256   PMID:26456622   PMID:26521100   PMID:26556524   PMID:26573281   PMID:26580676   PMID:26587656   PMID:26639454   PMID:26663068  
PMID:26690534   PMID:26722519   PMID:26727381   PMID:26730167   PMID:26781306   PMID:26817099   PMID:26822491   PMID:26873108   PMID:26916483   PMID:26961113   PMID:26970786   PMID:26971130  
PMID:26982740   PMID:26993229   PMID:27009617   PMID:27010145   PMID:27072325   PMID:27099220   PMID:27128002   PMID:27133299   PMID:27137706   PMID:27166533   PMID:27199033   PMID:27221874  
PMID:27239927   PMID:27249437   PMID:27288795   PMID:27304207   PMID:27308662   PMID:27323099   PMID:27348249   PMID:27353638   PMID:27356304   PMID:27368038   PMID:27388292   PMID:27432733  
PMID:27432796   PMID:27450232   PMID:27467078   PMID:27488401   PMID:27551817   PMID:27611887   PMID:27617498   PMID:27634953   PMID:27637911   PMID:27641812   PMID:27653892   PMID:27661054  
PMID:27663770   PMID:27728892   PMID:27803446   PMID:27806998   PMID:27875029   PMID:27915083   PMID:27924429   PMID:27977637   PMID:28070995   PMID:28076455   PMID:28083610   PMID:28095090  
PMID:28117133   PMID:28117433   PMID:28164572   PMID:28256105   PMID:28289237   PMID:28321022   PMID:28329746   PMID:28368717   PMID:28378544   PMID:28391407   PMID:28473221   PMID:28513222  
PMID:28514442   PMID:28577017   PMID:28631703   PMID:28638276   PMID:28685218   PMID:28687336   PMID:28745576   PMID:28745582   PMID:28777243   PMID:28785581   PMID:28798474   PMID:28802144  
PMID:28834922   PMID:28840784   PMID:28850715   PMID:28875498   PMID:28884817   PMID:28976264   PMID:28990182   PMID:29023140   PMID:29098786   PMID:29181698   PMID:29188612   PMID:29209919  
PMID:29243114   PMID:29260275   PMID:29279531   PMID:29279846   PMID:29288619   PMID:29311135   PMID:29325448   PMID:29347970   PMID:29350207   PMID:29352151   PMID:29397568   PMID:29461866  
PMID:29479969   PMID:29482947   PMID:29509167   PMID:29520080   PMID:29524040   PMID:29615454   PMID:29665549   PMID:29733119   PMID:29738309   PMID:29848980   PMID:29889439   PMID:29979852  
PMID:30017169   PMID:30022682   PMID:30028231   PMID:30061570   PMID:30073432   PMID:30092595   PMID:30188374   PMID:30191759   PMID:30325490   PMID:30325732   PMID:30342278   PMID:30381727  
PMID:30468857   PMID:30606386   PMID:30653146   PMID:30656556   PMID:30817183   PMID:30826566   PMID:30868490   PMID:30916611   PMID:30932939   PMID:30983508   PMID:31006731   PMID:31066578  
PMID:31124417   PMID:31128914   PMID:31134829   PMID:31358955   PMID:31395432   PMID:31543510   PMID:31571629   PMID:31713493   PMID:31726963   PMID:31797717   PMID:31834317   PMID:31849282  
PMID:31900240   PMID:31916702   PMID:31957547   PMID:31957548   PMID:32100936   PMID:32216088   PMID:32282698   PMID:32392440   PMID:32427413   PMID:32485484   PMID:32602114   PMID:32616329  
PMID:32644829   PMID:32678355   PMID:32702814   PMID:32826605   PMID:32862511   PMID:32957760   PMID:33124772   PMID:33232775   PMID:33370281   PMID:33432065   PMID:33503046   PMID:33578542  
PMID:33685396   PMID:33707344   PMID:33766706  


Genomics

Comparative Map Data
CYP2C19
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1094,762,681 - 94,855,547 (+)EnsemblGRCh38hg38GRCh38
GRCh381094,762,681 - 94,855,547 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371096,522,438 - 96,615,304 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361096,512,453 - 96,602,661 (+)NCBINCBI36hg18NCBI36
Build 341096,512,452 - 96,602,661NCBI
Celera1090,262,555 - 90,352,777 (+)NCBI
Cytogenetic Map10q23.33NCBI
HuRef1090,149,122 - 90,239,340 (+)NCBIHuRef
CHM1_11096,804,212 - 96,894,435 (+)NCBICHM1_1
Cyp2c38
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391939,378,000 - 39,451,547 (-)NCBIGRCm39mm39
GRCm39 Ensembl1939,378,000 - 39,451,519 (-)Ensembl
GRCm381939,389,556 - 39,463,103 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1939,389,556 - 39,463,075 (-)EnsemblGRCm38mm10GRCm38
MGSCv371939,464,046 - 39,537,565 (-)NCBIGRCm37mm9NCBIm37
MGSCv361939,442,867 - 39,516,386 (-)NCBImm8
MGSCv361939,107,245 - 39,170,091 (-)NCBImm8
Celera1940,194,429 - 40,266,552 (-)NCBICelera
Cytogenetic Map19C3NCBI
Cyp2c6v1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21237,938,521 - 237,976,238 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1237,693,094 - 238,057,596 (+)Ensembl
Rnor_6.01147,713,879 - 147,814,410 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1147,713,892 - 147,888,007 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01153,451,394 - 153,454,476 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01154,005,928 - 154,103,310 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41243,859,015 - 243,896,003 (+)ENTREZGENERGSC3.4rn4RGSC3.4
Celera1137,119,477 - 137,156,491 (+)NCBICelera
Cytogenetic Map1q31NCBI
CYP2C19
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11094,883,037 - 94,972,353 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1094,884,472 - 94,970,065 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01091,375,255 - 91,465,215 (+)NCBIMhudiblu_PPA_v0panPan3
CYP2C49
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.114106,571,803 - 106,612,082 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214116,191,543 - 116,244,868 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CYP2C19
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1987,981,300 - 88,025,007 (+)NCBI
Vero_WHO_p1.0NW_02366604848,761,705 - 48,797,570 (+)NCBI

Position Markers
STS-L07093  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371096,612,678 - 96,612,815UniSTSGRCh37
Build 361096,602,668 - 96,602,805RGDNCBI36
Celera1090,352,784 - 90,352,921RGD
Cytogenetic Map10q24UniSTS
HuRef1090,239,347 - 90,239,484UniSTS
GeneMap99-GB4 RH Map10445.19UniSTS
NCBI RH Map101042.5UniSTS
RH80282  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371096,612,664 - 96,612,782UniSTSGRCh37
Build 361096,602,654 - 96,602,772RGDNCBI36
Celera1090,352,770 - 90,352,888RGD
Cytogenetic Map10q24UniSTS
HuRef1090,239,333 - 90,239,451UniSTS
GeneMap99-GB4 RH Map10445.98UniSTS
GDB:193845  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371096,522,492 - 96,522,629UniSTSGRCh37
GRCh371096,698,469 - 96,698,605UniSTSGRCh37
Build 361096,512,482 - 96,512,619RGDNCBI36
Celera1090,438,587 - 90,438,723UniSTS
Celera1090,262,584 - 90,262,721RGD
Cytogenetic Map10q24UniSTS
HuRef1090,325,147 - 90,325,283UniSTS
GDB:364118  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371096,541,498 - 96,541,665UniSTSGRCh37
Build 361096,531,488 - 96,531,655RGDNCBI36
Celera1090,281,607 - 90,281,774RGD
Cytogenetic Map10q24UniSTS
HuRef1090,168,176 - 90,168,343UniSTS
RH70868  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371096,612,675 - 96,612,897UniSTSGRCh37
Build 361096,602,665 - 96,602,887RGDNCBI36
Celera1090,352,781 - 90,353,003RGD
Cytogenetic Map10q24UniSTS
HuRef1090,239,344 - 90,239,566UniSTS
GeneMap99-GB4 RH Map10448.63UniSTS
NCBI RH Map101036.4UniSTS
D10S2360  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371096,702,079 - 96,702,306UniSTSGRCh37
GRCh371096,535,277 - 96,535,503UniSTSGRCh37
Build 361096,525,267 - 96,525,493RGDNCBI36
Celera1090,442,197 - 90,442,424UniSTS
Celera1090,275,373 - 90,275,599RGD
Cytogenetic Map10q24UniSTS
HuRef1090,161,940 - 90,162,166UniSTS
HuRef1090,328,758 - 90,328,985UniSTS
GeneMap99-G3 RH Map104615.0UniSTS
GDB:364113  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10q24UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:314
Count of miRNA genes:247
Interacting mature miRNAs:254
Transcripts:ENST00000371321, ENST00000464755, ENST00000480405
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 114 203 205 67 203 1 2
Low 496 17 202 234 92 205 738 5 4 2 119 34 32 3 339
Below cutoff 729 672 361 126 338 25 1165 528 1769 92 523 613 101 467 729 2

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_008384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB113829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH011198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL133513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL583836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY796203 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB158473 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB161988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF459664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KF459665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY823012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY823013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY823014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY823015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KY946734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L31506 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L31507 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L32982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L32983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M61854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X65962 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000371321   ⟹   ENSP00000360372
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1094,762,681 - 94,855,547 (+)Ensembl
RefSeq Acc Id: ENST00000480405   ⟹   ENSP00000483847
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1094,762,681 - 94,776,450 (+)Ensembl
RefSeq Acc Id: ENST00000645461
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1094,773,837 - 94,853,164 (+)Ensembl
RefSeq Acc Id: NM_000769   ⟹   NP_000760
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381094,762,681 - 94,855,547 (+)NCBI
GRCh371096,522,463 - 96,612,671 (+)ENTREZGENE
Build 361096,512,453 - 96,602,661 (+)NCBI Archive
HuRef1090,149,122 - 90,239,340 (+)ENTREZGENE
CHM1_11096,804,187 - 96,894,726 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_000760   ⟸   NM_000769
- Peptide Label: precursor
- UniProtKB: P33261 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000360372   ⟸   ENST00000371321
RefSeq Acc Id: ENSP00000483847   ⟸   ENST00000480405

Promoters
RGD ID:7218231
Promoter ID:EPDNEW_H14862
Type:initiation region
Name:CYP2C19_1
Description:cytochrome P450 family 2 subfamily C member 19
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H14863  EPDNEW_H14864  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381094,762,681 - 94,762,741EPDNEW
RGD ID:7218235
Promoter ID:EPDNEW_H14863
Type:single initiation site
Name:CYP2C19_3
Description:cytochrome P450 family 2 subfamily C member 19
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H14862  EPDNEW_H14864  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381094,775,489 - 94,775,549EPDNEW
RGD ID:7218239
Promoter ID:EPDNEW_H14864
Type:multiple initiation site
Name:CYP2C19_2
Description:cytochrome P450 family 2 subfamily C member 19
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H14862  EPDNEW_H14863  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381094,842,926 - 94,842,986EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NM_000769.1(CYP2C19):c.681G>A (p.Pro227=) single nucleotide variant Clopidogrel response [RCV000018395]|Mephenytoin, poor metabolism of [RCV000018393]|Proguanil, poor metabolism of [RCV000018394]|amitriptyline response - Efficacy [RCV000211209]|citalopram response - Efficacy [RCV000211331]|clomipramine response - Efficacy [RCV000211423]|clopidogrel response - Efficacy, Toxicity/ADR [RCV000211298]|not provided [RCV000352637]|not specified [RCV000610614] Chr10:94781859 [GRCh38]
Chr10:96541616 [GRCh37]
Chr10:10q23.33
pathogenic|likely benign|drug response|other
CYP2C19*5 single nucleotide variant CYP2C19: no function [RCV000783657]|Mephenytoin, poor metabolism of [RCV000018396]|not provided [RCV000348667] Chr10:94852738 [GRCh38]
Chr10:96612495 [GRCh37]
Chr10:10q23.33
pathogenic|drug response|other
CYP2C19*3 single nucleotide variant CYP2C19: no function [RCV000783656]|Mephenytoin, poor metabolism of [RCV000018397]|Proguanil, poor metabolism of [RCV000018398]|clopidogrel response - Efficacy, Toxicity/ADR [RCV000211151]|not provided [RCV000291495] Chr10:94780653 [GRCh38]
Chr10:96540410 [GRCh37]
Chr10:10q23.33
drug response|other
CYP2C19*4A single nucleotide variant CYP2C19: no function [RCV000782432]|Mephenytoin, poor metabolism of [RCV000018399]|clopidogrel response - Efficacy [RCV000211166]|not provided [RCV000383294] Chr10:94762706 [GRCh38]
Chr10:96522463 [GRCh37]
Chr10:10q23.33
pathogenic|likely benign|drug response|other
GRCh38/hg38 10q23.33-24.2(chr10:92626680-97755102)x1 copy number loss See cases [RCV000052564] Chr10:92626680..97755102 [GRCh38]
Chr10:94386437..99514859 [GRCh37]
Chr10:94376417..99504849 [NCBI36]
Chr10:10q23.33-24.2
pathogenic
GRCh38/hg38 10q23.33-24.32(chr10:93181201-101356779)x1 copy number loss See cases [RCV000052565] Chr10:93181201..101356779 [GRCh38]
Chr10:94940958..103116536 [GRCh37]
Chr10:94930948..103106526 [NCBI36]
Chr10:10q23.33-24.32
pathogenic
GRCh38/hg38 10q23.31-26.3(chr10:91048545-133620674)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053560]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053560]|See cases [RCV000053560] Chr10:91048545..133620674 [GRCh38]
Chr10:92808302..135434178 [GRCh37]
Chr10:92798282..135284168 [NCBI36]
Chr10:10q23.31-26.3
pathogenic
NM_000769.2(CYP2C19):c.48C>T (p.Leu16=) single nucleotide variant Malignant melanoma [RCV000069093] Chr10:94762753 [GRCh38]
Chr10:96522510 [GRCh37]
Chr10:96512500 [NCBI36]
Chr10:10q23.33
not provided
NM_000769.2(CYP2C19):c.73G>A (p.Gly25Arg) single nucleotide variant Malignant melanoma [RCV000069094] Chr10:94762778 [GRCh38]
Chr10:96522535 [GRCh37]
Chr10:96512525 [NCBI36]
Chr10:10q23.33
not provided
NM_000769.2(CYP2C19):c.74G>A (p.Gly25Glu) single nucleotide variant Malignant melanoma [RCV000069095] Chr10:94762779 [GRCh38]
Chr10:96522536 [GRCh37]
Chr10:96512526 [NCBI36]
Chr10:10q23.33
not provided
NM_000769.2(CYP2C19):c.276G>A (p.Glu92=) single nucleotide variant Malignant melanoma [RCV000069096] Chr10:94775165 [GRCh38]
Chr10:96534922 [GRCh37]
Chr10:96524912 [NCBI36]
Chr10:10q23.33
not provided
NM_000769.2(CYP2C19):c.332G>A (p.Gly111Glu) single nucleotide variant Malignant melanoma [RCV000069097] Chr10:94775390 [GRCh38]
Chr10:96535147 [GRCh37]
Chr10:96525137 [NCBI36]
Chr10:10q23.33
not provided
NM_000769.2(CYP2C19):c.666C>T (p.Ile222=) single nucleotide variant Malignant melanoma [RCV000069098] Chr10:94781844 [GRCh38]
Chr10:96541601 [GRCh37]
Chr10:96531591 [NCBI36]
Chr10:10q23.33
not provided
NM_000769.2(CYP2C19):c.1113C>T (p.Thr371=) single nucleotide variant Malignant melanoma [RCV000069099] Chr10:94842988 [GRCh38]
Chr10:96602745 [GRCh37]
Chr10:96592735 [NCBI36]
Chr10:10q23.33
not provided
NM_000769.2(CYP2C19):c.1128C>T (p.Phe376=) single nucleotide variant Malignant melanoma [RCV000069100] Chr10:94843003 [GRCh38]
Chr10:96602760 [GRCh37]
Chr10:96592750 [NCBI36]
Chr10:10q23.33
not provided
NM_000769.2(CYP2C19):c.853G>A (p.Glu285Lys) single nucleotide variant Malignant melanoma [RCV000062099] Chr10:94820529 [GRCh38]
Chr10:96580286 [GRCh37]
Chr10:96570276 [NCBI36]
Chr10:10q23.33
not provided
NM_000769.4(CYP2C19):c.1137C>A (p.Tyr379Ter) single nucleotide variant CYP2C19-related poor drug metabolism [RCV001332578] Chr10:94843012 [GRCh38]
Chr10:96602769 [GRCh37]
Chr10:10q23.33
pathogenic
NM_000769.4(CYP2C19):c.-806C>A single nucleotide variant citalopram response - Metabolism/PK [RCV000211253]|clopidogrel response - Dosage, Efficacy, Toxicity/ADR [RCV000211201]|escitalopram response - Metabolism/PK [RCV000211375] Chr10:94761900 [GRCh38]
Chr10:96521657 [GRCh37]
Chr10:10q23.33
drug response
GRCh38/hg38 10q23.33(chr10:94298267-95267990)x1 copy number loss See cases [RCV000134773] Chr10:94298267..95267990 [GRCh38]
Chr10:96058024..97027747 [GRCh37]
Chr10:96048014..97017737 [NCBI36]
Chr10:10q23.33
uncertain significance
GRCh38/hg38 10q23.33(chr10:94694073-94853007)x1 copy number loss See cases [RCV000136823] Chr10:94694073..94853007 [GRCh38]
Chr10:96453830..96612764 [GRCh37]
Chr10:96443820..96602754 [NCBI36]
Chr10:10q23.33
benign
GRCh38/hg38 10q23.33-24.1(chr10:94401557-95444828)x3 copy number gain See cases [RCV000137970] Chr10:94401557..95444828 [GRCh38]
Chr10:96161314..97204585 [GRCh37]
Chr10:96151304..97194575 [NCBI36]
Chr10:10q23.33-24.1
uncertain significance
GRCh38/hg38 10q23.33-24.1(chr10:92643919-95471137)x1 copy number loss See cases [RCV000137919] Chr10:92643919..95471137 [GRCh38]
Chr10:94403676..97230894 [GRCh37]
Chr10:94393656..97220884 [NCBI36]
Chr10:10q23.33-24.1
pathogenic
GRCh38/hg38 10q23.33(chr10:94760469-94780679)x1 copy number loss See cases [RCV000141184] Chr10:94760469..94780679 [GRCh38]
Chr10:96520226..96540436 [GRCh37]
Chr10:96510216..96530426 [NCBI36]
Chr10:10q23.33
benign
GRCh38/hg38 10q23.33-24.1(chr10:94376979-95466604)x3 copy number gain See cases [RCV000142079] Chr10:94376979..95466604 [GRCh38]
Chr10:96136736..97226361 [GRCh37]
Chr10:96126726..97216351 [NCBI36]
Chr10:10q23.33-24.1
uncertain significance
Single allele deletion Normal pregnancy [RCV000161609] Chr10:94739953..94804000 [GRCh38]
Chr10:96499710..96563757 [GRCh37]
Chr10:10q23.33
not provided
CYP2C19*8 single nucleotide variant CYP2C19: no function [RCV000783659]|not provided [RCV000394401] Chr10:94775416 [GRCh38]
Chr10:96535173 [GRCh37]
Chr10:10q23.33
drug response|other
GRCh38/hg38 10q23.33(chr10:94739953-94797578)x1 copy number loss Premature ovarian failure [RCV000225238] Chr10:94739953..94797578 [GRCh38]
Chr10:96499710..96557335 [GRCh37]
Chr10:10q23.33
benign
CYP2C19*17 single nucleotide variant CYP2C19: increased function [RCV000782438]|not provided [RCV000326411] Chr10:94761900 [GRCh38]
Chr10:96521657 [GRCh37]
Chr10:10q23.33
benign|drug response|other
GRCh37/hg19 10q23.33-24.1(chr10:94393383-97219175) copy number loss not provided [RCV000767566] Chr10:94393383..97219175 [GRCh37]
Chr10:10q23.33-24.1
likely pathogenic
GRCh37/hg19 10q23.31-24.1(chr10:92667881-98970384)x1 copy number loss See cases [RCV000447362] Chr10:92667881..98970384 [GRCh37]
Chr10:10q23.31-24.1
pathogenic
GRCh37/hg19 10q23.33(chr10:96383040-96623950)x1 copy number loss See cases [RCV000447385] Chr10:96383040..96623950 [GRCh37]
Chr10:10q23.33
uncertain significance
GRCh37/hg19 10q23.33(chr10:96401653-96523474)x1 copy number loss See cases [RCV000446750] Chr10:96401653..96523474 [GRCh37]
Chr10:10q23.33
likely benign
GRCh37/hg19 10q23.1-25.1(chr10:85557432-105804295)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000431909] Chr10:85557432..105804295 [GRCh37]
Chr10:10q23.1-25.1
pathogenic|drug response
GRCh37/hg19 10q23.33(chr10:96522575-96702831)x3 copy number gain See cases [RCV000448722] Chr10:96522575..96702831 [GRCh37]
Chr10:10q23.33
likely benign
GRCh37/hg19 10q23.33(chr10:96497751-96560546) copy number loss Abnormality of esophagus morphology [RCV000416919] Chr10:96497751..96560546 [GRCh37]
Chr10:10q23.33
benign
GRCh37/hg19 10p15.3-q26.3(chr10:93297-135378918)x3 copy number gain See cases [RCV000448750] Chr10:93297..135378918 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143) copy number gain See cases [RCV000511389] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic|uncertain significance
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143)x3 copy number gain See cases [RCV000510861] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10q23.32-26.3(chr10:93283493-135427143)x3 copy number gain See cases [RCV000510972] Chr10:93283493..135427143 [GRCh37]
Chr10:10q23.32-26.3
pathogenic
GRCh37/hg19 10q11.21-26.3(chr10:42347406-135534747)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626438] Chr10:42347406..135534747 [GRCh37]
Chr10:10q11.21-26.3
drug response
GRCh37/hg19 10q23.32-24.2(chr10:93908171-101809723)x1 copy number loss See cases [RCV000512315] Chr10:93908171..101809723 [GRCh37]
Chr10:10q23.32-24.2
pathogenic
GRCh37/hg19 10q23.33(chr10:96575687-96711450)x3 copy number gain not provided [RCV000659231] Chr10:96575687..96711450 [GRCh37]
Chr10:10q23.33
likely benign
GRCh37/hg19 10q23.33(chr10:96339490-96546534)x1 copy number loss not provided [RCV000683203] Chr10:96339490..96546534 [GRCh37]
Chr10:10q23.33
uncertain significance
GRCh37/hg19 10q23.33-26.3(chr10:94346520-135427143)x3 copy number gain not provided [RCV000683291] Chr10:94346520..135427143 [GRCh37]
Chr10:10q23.33-26.3
pathogenic
GRCh37/hg19 10q23.33(chr10:96407978-96622313)x1 copy number loss not provided [RCV000737279] Chr10:96407978..96622313 [GRCh37]
Chr10:10q23.33
benign
GRCh37/hg19 10q23.33(chr10:96528208-96541982)x1 copy number loss not provided [RCV000749780] Chr10:96528208..96541982 [GRCh37]
Chr10:10q23.33
benign
GRCh37/hg19 10q23.33(chr10:96541982-96602398)x0 copy number loss not provided [RCV000749781] Chr10:96541982..96602398 [GRCh37]
Chr10:10q23.33
benign
GRCh37/hg19 10q23.33(chr10:96541982-96647117)x0 copy number loss not provided [RCV000749782] Chr10:96541982..96647117 [GRCh37]
Chr10:10q23.33
benign
GRCh37/hg19 10p15.3-q26.3(chr10:73232-135524321)x3 copy number gain not provided [RCV000749464] Chr10:73232..135524321 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:98087-135477883)x3 copy number gain not provided [RCV000749465] Chr10:98087..135477883 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
NM_000769.1(CYP2C19):c.991A>G (p.Ile331Val) single nucleotide variant not provided [RCV000948522] Chr10:94842866 [GRCh38]
Chr10:96602623 [GRCh37]
Chr10:10q23.33
benign
NM_000769.4(CYP2C19):c.99C>T (p.Pro33=) single nucleotide variant not provided [RCV000948208] Chr10:94762804 [GRCh38]
Chr10:96522561 [GRCh37]
Chr10:10q23.33
benign
CYP2C19*26 single nucleotide variant CYP2C19: decreased function [RCV000782437] Chr10:94781944 [GRCh38]
Chr10:96541701 [GRCh37]
Chr10:10q23.33
drug response
CYP2C19*31 single nucleotide variant CYP2C19: uncertain function [RCV000782434] Chr10:94775121 [GRCh38]
Chr10:96534878 [GRCh37]
Chr10:10q23.33
drug response
CYP2C19*10 single nucleotide variant CYP2C19: decreased function [RCV000783652] Chr10:94781858 [GRCh38]
Chr10:96541615 [GRCh37]
Chr10:10q23.33
drug response
CYP2C19*19 single nucleotide variant CYP2C19: decreased function [RCV000783651] Chr10:94762856 [GRCh38]
Chr10:96522613 [GRCh37]
Chr10:10q23.33
drug response
CYP2C19*13 single nucleotide variant CYP2C19: normal function [RCV000782427] Chr10:94849995 [GRCh38]
Chr10:96609752 [GRCh37]
Chr10:10q23.33
drug response
CYP2C19*15 single nucleotide variant CYP2C19: normal function [RCV000783650]|not provided [RCV000893758] Chr10:94762760 [GRCh38]
Chr10:96522517 [GRCh37]
Chr10:10q23.33
benign|drug response
CYP2C19*29 single nucleotide variant CYP2C19: uncertain function [RCV000783661] Chr10:94762788 [GRCh38]
Chr10:96522545 [GRCh37]
Chr10:10q23.33
drug response
CYP2C19*35 single nucleotide variant CYP2C19: no function [RCV000782431] Chr10:94775367 [GRCh38]
Chr10:96535124 [GRCh37]
Chr10:10q23.33
drug response
CYP2C19*27 single nucleotide variant CYP2C19: uncertain function [RCV000782433] Chr10:94761665 [GRCh38]
Chr10:96521422 [GRCh37]
Chr10:10q23.33
drug response
GRCh37/hg19 10q23.33(chr10:96534277-96599102)x1 copy number loss not provided [RCV000847912] Chr10:96534277..96599102 [GRCh37]
Chr10:10q23.33
uncertain significance
CYP2C19*11 single nucleotide variant CYP2C19: normal function [RCV000782426] Chr10:94775507 [GRCh38]
Chr10:96535264 [GRCh37]
Chr10:10q23.33
drug response
CYP2C19*14 single nucleotide variant CYP2C19: uncertain function [RCV000783662] Chr10:94762755 [GRCh38]
Chr10:96522512 [GRCh37]
Chr10:10q23.33
drug response
CYP2C19*23 single nucleotide variant CYP2C19: uncertain function [RCV000783663] Chr10:94775160 [GRCh38]
Chr10:96534917 [GRCh37]
Chr10:10q23.33
drug response
CYP2C19*30 single nucleotide variant CYP2C19: uncertain function [RCV000782429] Chr10:94775106 [GRCh38]
Chr10:96534863 [GRCh37]
Chr10:10q23.33
drug response
CYP2C19*9 single nucleotide variant CYP2C19: decreased function [RCV000783660] Chr10:94775489 [GRCh38]
Chr10:96535246 [GRCh37]
Chr10:10q23.33
drug response
CYP2C19*22 single nucleotide variant CYP2C19: no function [RCV000782424] Chr10:94780574 [GRCh38]
Chr10:96540331 [GRCh37]
Chr10:10q23.33
drug response
CYP2C19*6 single nucleotide variant CYP2C19: no function [RCV000782436] Chr10:94775453 [GRCh38]
Chr10:96535210 [GRCh37]
Chr10:10q23.33
drug response
CYP2C19*7 single nucleotide variant CYP2C19: no function [RCV000783658] Chr10:94781999 [GRCh38]
Chr10:96541756 [GRCh37]
Chr10:10q23.33
drug response
CYP2C19*32 single nucleotide variant CYP2C19: uncertain function [RCV000782422] Chr10:94775185 [GRCh38]
Chr10:96534942 [GRCh37]
Chr10:10q23.33
drug response
GRCh37/hg19 10q23.33(chr10:96533912-96598380)x1 copy number loss not provided [RCV000847207] Chr10:96533912..96598380 [GRCh37]
Chr10:10q23.33
uncertain significance
CYP2C19*16 single nucleotide variant CYP2C19: decreased function [RCV000782430] Chr10:94852765 [GRCh38]
Chr10:96612522 [GRCh37]
Chr10:10q23.33
drug response
CYP2C19*25 single nucleotide variant CYP2C19: decreased function [RCV000783653] Chr10:94852785 [GRCh38]
Chr10:96612542 [GRCh37]
Chr10:10q23.33
drug response
CYP2C19*1 variation CYP2C19: normal function [RCV000783655] Chr10:94762681..94853205 [GRCh38]
Chr10:10q23.33
drug response
CYP2C19*12 single nucleotide variant CYP2C19: uncertain function [RCV000782435] Chr10:94852914 [GRCh38]
Chr10:96612671 [GRCh37]
Chr10:10q23.33
pathogenic|drug response
CYP2C19*33 single nucleotide variant CYP2C19: uncertain function [RCV000782421] Chr10:94780579 [GRCh38]
Chr10:96540336 [GRCh37]
Chr10:10q23.33
drug response
GRCh37/hg19 10q23.33(chr10:96558287-96606761)x1 copy number loss not provided [RCV000845773] Chr10:96558287..96606761 [GRCh37]
Chr10:10q23.33
uncertain significance
CYP2C19*18 single nucleotide variant CYP2C19: normal function [RCV000782423] Chr10:94842861 [GRCh38]
Chr10:96602618 [GRCh37]
Chr10:10q23.33
drug response
GRCh37/hg19 10q23.33(chr10:96501534-96548712)x1 copy number loss not provided [RCV000849788] Chr10:96501534..96548712 [GRCh37]
Chr10:10q23.33
uncertain significance
GRCh37/hg19 10q23.33(chr10:96562918-96606761)x1 copy number loss not provided [RCV000846897] Chr10:96562918..96606761 [GRCh37]
Chr10:10q23.33
uncertain significance
GRCh37/hg19 10q23.33(chr10:96502305-96562508)x1 copy number loss not provided [RCV000847317] Chr10:96502305..96562508 [GRCh37]
Chr10:10q23.33
uncertain significance
NM_000769.4(CYP2C19):c.1173C>A (p.Leu391=) single nucleotide variant not provided [RCV000924496] Chr10:94849940 [GRCh38]
Chr10:96609697 [GRCh37]
Chr10:10q23.33
likely benign
GRCh37/hg19 10q23.33-24.1(chr10:96140621-97222801)x3 copy number gain not provided [RCV001258459] Chr10:96140621..97222801 [GRCh37]
Chr10:10q23.33-24.1
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:2621 AgrOrtholog
COSMIC CYP2C19 COSMIC
Ensembl Genes ENSG00000165841 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000360372 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000483847 UniProtKB/TrEMBL
Ensembl Transcript ENST00000371321 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000480405 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000165841 GTEx
HGNC ID HGNC:2621 ENTREZGENE
Human Proteome Map CYP2C19 Human Proteome Map
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:1557 UniProtKB/Swiss-Prot
NCBI Gene 1557 ENTREZGENE
OMIM 124020 OMIM
  609535 OMIM
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CYP2C19 RGD, PharmGKB
PRINTS EP450I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A087X125_HUMAN UniProtKB/TrEMBL
  A0A2D1BII0_HUMAN UniProtKB/TrEMBL
  A0A2D1BPP2_HUMAN UniProtKB/TrEMBL
  B0ZDM8_HUMAN UniProtKB/TrEMBL
  CP2CJ_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q767A3_HUMAN UniProtKB/TrEMBL
UniProt Secondary P33259 UniProtKB/Swiss-Prot
  Q8WZB1 UniProtKB/Swiss-Prot
  Q8WZB2 UniProtKB/Swiss-Prot
  Q9UCD4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-15 CYP2C19  cytochrome P450 family 2 subfamily C member 19    cytochrome P450, family 2, subfamily C, polypeptide 19  Symbol and/or name change 5135510 APPROVED
2011-08-16 CYP2C19  cytochrome P450, family 2, subfamily C, polypeptide 19  CYP2C19  cytochrome P450, family 2, subfamily C, polypeptide 19  Symbol and/or name change 5135510 APPROVED