Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: CYP2C19 (cytochrome P450 family 2 subfamily C member 19) Homo sapiens
Symbol: CYP2C19
Name: cytochrome P450 family 2 subfamily C member 19
Description: Exhibits enzyme binding activity; heme binding activity; and steroid hydroxylase activity. Involved in several processes, including exogenous drug catabolic process; monoterpenoid metabolic process; and steroid metabolic process. Predicted to localize to cytoplasm and intracellular membrane-bounded organelle. Implicated in eosinophilic esophagitis; multiple myeloma; and sickle cell anemia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: (R)-limonene 6-monooxygenase; (S)-limonene 6-monooxygenase; (S)-limonene 7-monooxygenase; CPCJ; CYP2C; CYPIIC17; CYPIIC19; cytochrome P-450 II C; cytochrome P450 2C19; cytochrome P450, family 2, subfamily C, polypeptide 19; cytochrome p450, subfamily iic (mephenytoin 4-hydroxylase); cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 19; cytochrome P450-11A; cytochrome P450-254C; fenbendazole monooxygenase (4'-hydroxylating); flavoprotein-linked monooxygenase; mephenytoin 4'-hydroxylase; mephenytoin 4-hydroxylase; microsomal monooxygenase; P450C2C; P450IIC19; S-mephenytoin 4-hydroxylase; xenobiotic monooxygenase
Related Pseudogenes: CYP2C63P   CYP2C64P  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1094,762,681 - 94,855,547 (+)EnsemblGRCh38hg38GRCh38
GRCh381094,762,681 - 94,855,547 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371096,522,463 - 96,612,671 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361096,512,453 - 96,602,661 (+)NCBINCBI36hg18NCBI36
Build 341096,512,452 - 96,602,661NCBI
Celera1090,262,555 - 90,352,777 (+)NCBI
Cytogenetic Map10q23.33NCBI
HuRef1090,149,122 - 90,239,340 (+)NCBIHuRef
CHM1_11096,804,187 - 96,894,726 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CYP2C19
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737416
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-09-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.