TNFRSF10A (TNF receptor superfamily member 10a) - Rat Genome Database

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Gene: TNFRSF10A (TNF receptor superfamily member 10a) Homo sapiens
Analyze
Symbol: TNFRSF10A
Name: TNF receptor superfamily member 10a
RGD ID: 1317580
HGNC Page HGNC:11904
Description: Enables identical protein binding activity and protease binding activity. Involved in TRAIL-activated apoptotic signaling pathway and cellular response to mechanical stimulus. Located in several cellular components, including Golgi apparatus; cell surface; and membrane raft. Is active in plasma membrane raft. Implicated in carcinoma (multiple); cervical cancer; hematologic cancer (multiple); and urinary bladder cancer. Biomarker of breast ductal carcinoma and renal cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: APO2; CD261; cytotoxic TRAIL receptor; death receptor 4; DR4; MGC9365; TNF-related apoptosis inducing ligand receptor 1; TNF-related apoptosis-inducing ligand receptor 1; TRAIL receptor 1; TRAIL-R1; TRAILR-1; TRAILR1; tumor necrosis factor receptor superfamily member 10A; tumor necrosis factor receptor superfamily member 10a variant 2; tumor necrosis factor receptor superfamily, member 10a
RGD Orthologs
Mouse
Rat
Bonobo
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38823,190,452 - 23,225,102 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl823,190,452 - 23,225,102 (-)EnsemblGRCh38hg38GRCh38
GRCh37823,047,965 - 23,082,615 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36823,104,915 - 23,138,584 (-)NCBINCBI36Build 36hg18NCBI36
Build 34823,104,915 - 23,138,584NCBI
Celera822,011,569 - 22,045,255 (-)NCBICelera
Cytogenetic Map8p21.3NCBI
HuRef821,594,946 - 21,628,637 (-)NCBIHuRef
CHM1_1823,251,086 - 23,284,807 (-)NCBICHM1_1
T2T-CHM13v2.0823,465,337 - 23,499,970 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (EXP)
1-fluoro-2,4-dinitrobenzene  (EXP)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-tert-butylphenol  (EXP)
5-aza-2'-deoxycytidine  (EXP)
5-fluorouracil  (EXP)
8-Br-cAMP  (EXP)
9-cis-retinoic acid  (EXP)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (EXP)
alvocidib  (EXP)
aristolochic acid A  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (EXP,ISO)
atazanavir sulfate  (EXP)
benzo[a]pyrene  (EXP)
benzo[a]pyrene diol epoxide I  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
bortezomib  (EXP)
brefeldin A  (EXP)
Brevetoxin B  (EXP)
bupropion  (EXP)
butanal  (EXP)
Butylparaben  (EXP)
caffeine  (EXP)
cannabidiol  (EXP)
cantharidin  (EXP)
capsaicin  (EXP)
carbamazepine  (EXP)
carbon nanotube  (EXP)
celastrol  (EXP)
celecoxib  (EXP)
chenodeoxycholic acid  (EXP)
chlorambucil  (EXP)
chloroquine  (EXP)
chlorpyrifos  (EXP)
chromium(6+)  (EXP)
cisplatin  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (EXP)
copper(II) sulfate  (EXP)
curcumin  (EXP)
cycloheximide  (EXP)
cyclosporin A  (EXP)
cylindrospermopsin  (EXP)
daunorubicin  (EXP)
deoxycholic acid  (EXP)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
dimethylselenide  (EXP)
dioxygen  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP)
DuP 697  (EXP)
elemental selenium  (EXP)
embelin  (EXP)
entinostat  (EXP,ISO)
epichlorohydrin  (EXP)
esculetin  (EXP)
ethyl methanesulfonate  (EXP)
fluvastatin  (EXP)
formaldehyde  (EXP)
genistein  (EXP)
glycochenodeoxycholic acid  (EXP)
glycocholic acid  (EXP)
glycodeoxycholic acid  (EXP)
glyphosate  (EXP)
gold atom  (EXP)
gold(0)  (EXP)
helenalin  (EXP)
hydroxyl  (EXP)
hydroxyurea  (ISO)
Ilimaquinone  (EXP)
Isoangustone A  (EXP)
Licochalcone B  (EXP)
lupulone  (EXP)
LY294002  (EXP)
Maduramicin  (ISO)
magnesium oxide  (EXP)
melittin  (EXP)
mercury dibromide  (EXP)
metformin  (EXP)
methotrexate  (EXP)
methyl methanesulfonate  (EXP)
methylmercury chloride  (EXP)
metiram  (EXP)
N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide  (EXP)
N-acetyl-L-cysteine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-Nitrosopyrrolidine  (EXP)
nefazodone  (EXP)
nickel atom  (EXP)
Nonidet P-40  (EXP)
NS-398  (EXP)
nystatin  (EXP)
o-anisidine  (EXP)
O-methyleugenol  (EXP)
ouabain  (EXP)
ozone  (EXP)
p-menthan-3-ol  (EXP)
paclitaxel  (EXP)
paraquat  (EXP)
Pendulone  (EXP)
Pentoxifylline  (EXP)
perfluorooctanoic acid  (EXP)
phenethyl caffeate  (EXP)
phenylmercury acetate  (EXP)
propanal  (EXP)
propylparaben  (EXP)
pyrethrins  (EXP)
quercetin  (EXP)
resveratrol  (EXP)
SB 431542  (EXP)
SC-58125  (EXP)
selenium atom  (EXP)
sesquiterpene  (EXP)
sodium arsenate  (EXP)
sulforaphane  (EXP)
sulindac sulfide  (EXP)
sunitinib  (EXP)
temozolomide  (EXP)
thalidomide  (EXP)
thymoquinone  (EXP)
trichostatin A  (EXP)
triclosan  (EXP)
triphenyl phosphate  (EXP)
Triptolide  (ISO)
troglitazone  (EXP)
usnic acid  (EXP)
valproic acid  (EXP)
vemurafenib  (EXP)
vismodegib  (EXP)
vorinostat  (EXP)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell surface  (IBA,IDA)
cytoplasm  (IEA)
cytosol  (IDA,IEA)
Golgi apparatus  (IDA)
membrane  (IEA)
membrane raft  (IDA,IEA)
plasma membrane  (IBA,IDA,IEA,TAS)
plasma membrane raft  (IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Lymphoma  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Identification of gene expression profiles correlated to tumor progression in a preclinical model of colon carcinogenesis. Bousserouel S, etal., Int J Oncol. 2010 Jun;36(6):1485-90.
2. Comparative transcriptional and functional profiling of clear cell and papillary renal cell carcinoma. Diegmann J, etal., Int J Mol Med. 2006 Sep;18(3):395-403.
3. Efficacy of anti-death receptor 5 (DR5) antibody (TRA-8) against primary human ovarian carcinoma using a novel ex vivo tissue slice model. Estes JM, etal., Gynecol Oncol. 2007 May;105(2):291-8. Epub 2007 Feb 15.
4. TRAIL signalling: decisions between life and death. Falschlehner C, etal., Int J Biochem Cell Biol. 2007;39(7-8):1462-75. Epub 2007 Feb 14.
5. Frequent polymorphic changes but not mutations of TRAIL receptors DR4 and DR5 in mantle cell lymphoma and other B-cell lymphoid neoplasms. Fernandez V, etal., Haematologica. 2004 Nov;89(11):1322-31.
6. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
7. Stimulation of erythropoiesis by thalidomide in multiple myeloma patients: its influence on FasL, TRAIL and their receptors on erythroblasts. Grzasko N, etal., Haematologica. 2006 Mar;91(3):386-9.
8. Interleukin-15 is associated with disease severity in viral bronchiolitis. Leahy TR, etal., Eur Respir J. 2016 Jan;47(1):212-22. doi: 10.1183/13993003.00642-2015. Epub 2015 Nov 5.
9. Evaluating the expression and prognostic value of TRAIL-R1 and TRAIL-R2 in breast cancer. McCarthy MM, etal., Clin Cancer Res. 2005 Jul 15;11(14):5188-94.
10. Playing the DISC: turning on TRAIL death receptor-mediated apoptosis in cancer. Pennarun B, etal., Biochim Biophys Acta. 2010 Apr;1805(2):123-40. Epub 2009 Dec 2.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Anti-tumor activity of TRA-8 anti-death receptor 5 (DR5) monoclonal antibody in combination with chemotherapy and radiation therapy in a cervical cancer model. Straughn JM Jr, etal., Gynecol Oncol. 2006 Apr;101(1):46-54. Epub 2005 Nov 4.
16. Differential apoptosis gene expression in pediatric tumors of the kidney. Takamizawa S, etal., J Pediatr Surg. 2000 Feb;35(2):390-5.
17. Genetic expression profiles and chromosomal alterations in sporadic breast cancer in Mexican women. Valladares A, etal., Cancer Genet Cytogenet. 2006 Oct 15;170(2):147-51.
18. Ala228 variant of trail receptor 1 affecting the ligand binding site is associated with chronic lymphocytic leukemia, mantle cell lymphoma, prostate cancer, head and neck squamous cell carcinoma and bladder cancer. Wolf S, etal., Int J Cancer. 2006 Apr 1;118(7):1831-5.
19. Association between polymorphisms in cancer-related genes and early onset of esophageal adenocarcinoma. Wu IC, etal., Neoplasia. 2011 Apr;13(4):386-92. doi: 10.1593/neo.101722.
20. Lexatumumab (TRAIL-receptor 2 mAb) induces expression of DR5 and promotes apoptosis in primary and metastatic renal cell carcinoma in a mouse orthotopic model. Zhang L, etal., Cancer Lett. 2007 Jun 18;251(1):146-57. Epub 2006 Dec 20.
Additional References at PubMed
PMID:7650480   PMID:9082980   PMID:9311998   PMID:9325248   PMID:9373179   PMID:9382840   PMID:9430227   PMID:9430228   PMID:9811967   PMID:10400625   PMID:10549288   PMID:10594023  
PMID:10862756   PMID:10894160   PMID:11376335   PMID:11464292   PMID:11844843   PMID:11862476   PMID:12082627   PMID:12218097   PMID:12239152   PMID:12388693   PMID:12421985   PMID:12477932  
PMID:12488957   PMID:12649168   PMID:12808117   PMID:12839575   PMID:12920112   PMID:12927928   PMID:14506242   PMID:14534720   PMID:14576771   PMID:15007095   PMID:15146197   PMID:15208670  
PMID:15280356   PMID:15301860   PMID:15334061   PMID:15356269   PMID:15388581   PMID:15452120   PMID:15480430   PMID:15489334   PMID:15538968   PMID:15608691   PMID:15655781   PMID:15757891  
PMID:15861184   PMID:15863153   PMID:15921376   PMID:15949439   PMID:15972852   PMID:15975957   PMID:15990565   PMID:16012731   PMID:16046522   PMID:16051735   PMID:16174727   PMID:16226105  
PMID:16319225   PMID:16344560   PMID:16529749   PMID:16544055   PMID:16778114   PMID:16847314   PMID:17035413   PMID:17047155   PMID:17070520   PMID:17075118   PMID:17081983   PMID:17160022  
PMID:17666396   PMID:17881904   PMID:17907802   PMID:17983809   PMID:18163425   PMID:18165900   PMID:18203008   PMID:18305945   PMID:18421578   PMID:18511705   PMID:18556450   PMID:18590575  
PMID:18633131   PMID:18676680   PMID:18789900   PMID:18846110   PMID:18981952   PMID:19050264   PMID:19070628   PMID:19074831   PMID:19074885   PMID:19090789   PMID:19148581   PMID:19170196  
PMID:19203830   PMID:19212626   PMID:19305384   PMID:19343040   PMID:19349211   PMID:19350268   PMID:19379558   PMID:19424623   PMID:19427028   PMID:19434100   PMID:19453261   PMID:19505916  
PMID:19573080   PMID:19593445   PMID:19625176   PMID:19637313   PMID:19639179   PMID:19643115   PMID:19643596   PMID:19692168   PMID:19773279   PMID:19789190   PMID:19913121   PMID:19932172  
PMID:20103630   PMID:20237496   PMID:20354842   PMID:20363213   PMID:20421368   PMID:20430723   PMID:20453000   PMID:20484047   PMID:20556591   PMID:20568250   PMID:20628086   PMID:20638129  
PMID:20666744   PMID:20673328   PMID:20677014   PMID:20714870   PMID:20732625   PMID:20800603   PMID:20802294   PMID:20875141   PMID:20889918   PMID:21195543   PMID:21272366   PMID:21279373  
PMID:21367858   PMID:21484799   PMID:21519792   PMID:21685476   PMID:21700414   PMID:21769428   PMID:21785270   PMID:21785459   PMID:21873635   PMID:21909106   PMID:21953056   PMID:21994560  
PMID:22158615   PMID:22183068   PMID:22240897   PMID:22246181   PMID:22258765   PMID:22392486   PMID:22401174   PMID:22447040   PMID:22665066   PMID:22695614   PMID:22824792   PMID:22948392  
PMID:22952982   PMID:23050498   PMID:23142077   PMID:23284732   PMID:23300075   PMID:23306613   PMID:23322903   PMID:23423784   PMID:23455636   PMID:23460812   PMID:23498957   PMID:23584885  
PMID:23661154   PMID:23686163   PMID:23806100   PMID:23815209   PMID:23857473   PMID:23959437   PMID:24078627   PMID:24085293   PMID:24136227   PMID:24212133   PMID:24235014   PMID:24379239  
PMID:24492941   PMID:24551275   PMID:24587306   PMID:24695582   PMID:24761920   PMID:24764293   PMID:25026275   PMID:25230899   PMID:25293521   PMID:25605010   PMID:25605161   PMID:25691252  
PMID:25770212   PMID:25798684   PMID:25845236   PMID:25955868   PMID:25980612   PMID:26138346   PMID:26238205   PMID:26275133   PMID:26297860   PMID:26315998   PMID:26404509   PMID:26418999  
PMID:26457518   PMID:26518902   PMID:26561202   PMID:26708505   PMID:26718429   PMID:27321185   PMID:27492861   PMID:27576686   PMID:27721019   PMID:27750195   PMID:27780136   PMID:28039489  
PMID:28108622   PMID:28120533   PMID:28514442   PMID:28981087   PMID:28986522   PMID:29117863   PMID:29274253   PMID:29278689   PMID:29446085   PMID:29473798   PMID:29638207   PMID:29795330  
PMID:30064384   PMID:30430148   PMID:30468458   PMID:30514120   PMID:30589515   PMID:30833792   PMID:30912136   PMID:30945308   PMID:30987996   PMID:31094932   PMID:31114586   PMID:31183506  
PMID:31871319   PMID:32342239   PMID:32692906   PMID:33269432   PMID:33664875   PMID:33845483   PMID:33961781   PMID:34198757   PMID:34275891   PMID:34342264   PMID:35052395   PMID:36867660  


Genomics

Comparative Map Data
TNFRSF10A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38823,190,452 - 23,225,102 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl823,190,452 - 23,225,102 (-)EnsemblGRCh38hg38GRCh38
GRCh37823,047,965 - 23,082,615 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36823,104,915 - 23,138,584 (-)NCBINCBI36Build 36hg18NCBI36
Build 34823,104,915 - 23,138,584NCBI
Celera822,011,569 - 22,045,255 (-)NCBICelera
Cytogenetic Map8p21.3NCBI
HuRef821,594,946 - 21,628,637 (-)NCBIHuRef
CHM1_1823,251,086 - 23,284,807 (-)NCBICHM1_1
T2T-CHM13v2.0823,465,337 - 23,499,970 (-)NCBIT2T-CHM13v2.0
Tnfrsf10b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391470,004,921 - 70,021,860 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1470,004,921 - 70,021,860 (+)EnsemblGRCm39 Ensembl
GRCm381469,767,472 - 69,784,411 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1469,767,472 - 69,784,411 (+)EnsemblGRCm38mm10GRCm38
MGSCv371470,167,279 - 70,184,218 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361468,502,609 - 68,519,491 (+)NCBIMGSCv36mm8
Celera1467,301,078 - 67,318,034 (+)NCBICelera
Cytogenetic Map14D2NCBI
cM Map1436.1NCBI
Tnfrsf10b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81551,249,883 - 51,278,091 (+)NCBIGRCr8
mRatBN7.21544,840,386 - 44,868,318 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1544,840,386 - 44,867,467 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1548,958,259 - 48,986,200 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01550,069,754 - 50,097,693 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01546,929,101 - 46,957,032 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01551,433,853 - 51,464,215 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01555,161,595 - 55,192,095 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41550,138,439 - 50,163,254 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11550,155,031 - 50,177,989 (+)NCBI
Celera1544,522,716 - 44,548,374 (+)NCBICelera
Cytogenetic Map15p11NCBI
TNFRSF10A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2741,692,326 - 41,732,181 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1817,422,892 - 17,459,408 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0822,440,502 - 22,476,790 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1819,378,547 - 19,414,724 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl819,378,547 - 19,414,724 (-)Ensemblpanpan1.1panPan2
LOC100737977
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1147,344,788 - 7,371,086 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2147,869,520 - 7,886,618 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TNFRSF10A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1821,318,987 - 21,351,641 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl821,315,149 - 21,351,673 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605220,871,352 - 20,907,523 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in TNFRSF10A
62 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 8p23.1-11.21(chr8:12609975-42085703)x3 copy number gain See cases [RCV000050294] Chr8:12609975..42085703 [GRCh38]
Chr8:12467484..41943221 [GRCh37]
Chr8:12511855..42062378 [NCBI36]
Chr8:8p23.1-11.21		 pathogenic
GRCh38/hg38 8p23.3-21.1(chr8:2475295-27504279)x1 copy number loss See cases [RCV000050297] Chr8:2475295..27504279 [GRCh38]
Chr8:2292235..27361796 [GRCh37]
Chr8:2121457..27417713 [NCBI36]
Chr8:8p23.3-21.1		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12728904-43673207)x3 copy number gain See cases [RCV000050912] Chr8:12728904..43673207 [GRCh38]
Chr8:12586413..43528350 [GRCh37]
Chr8:12630784..43647507 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p23.1-12(chr8:12383584-36370018)x3 copy number gain See cases [RCV000051145] Chr8:12383584..36370018 [GRCh38]
Chr8:12241093..36227536 [GRCh37]
Chr8:12285464..36347088 [NCBI36]
Chr8:8p23.1-12		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145049449)x3 copy number gain See cases [RCV000051206] Chr8:241530..145049449 [GRCh38]
Chr8:191530..146274835 [GRCh37]
Chr8:181530..146245639 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p23.1-11.21(chr8:12728904-41928741)x3 copy number gain See cases [RCV000051110] Chr8:12728904..41928741 [GRCh38]
Chr8:12586413..41786259 [GRCh37]
Chr8:12630784..41905416 [NCBI36]
Chr8:8p23.1-11.21		 pathogenic
GRCh38/hg38 8p23.1-11.23(chr8:12609975-37892000)x3 copy number gain See cases [RCV000053629] Chr8:12609975..37892000 [GRCh38]
Chr8:12467484..37749518 [GRCh37]
Chr8:12511855..37868676 [NCBI36]
Chr8:8p23.1-11.23		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12609975-43336172)x3 copy number gain See cases [RCV000053630] Chr8:12609975..43336172 [GRCh38]
Chr8:12467484..43191315 [GRCh37]
Chr8:12511855..43310472 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12609975-43255410)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053631]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053631]|See cases [RCV000053631] Chr8:12609975..43255410 [GRCh38]
Chr8:12467484..43110553 [GRCh37]
Chr8:12511855..43229710 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12750796-43532444)x3 copy number gain See cases [RCV000053632] Chr8:12750796..43532444 [GRCh38]
Chr8:12608305..43387587 [GRCh37]
Chr8:12652676..43506744 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p23.1-12(chr8:12750796-29445409)x3 copy number gain See cases [RCV000053633] Chr8:12750796..29445409 [GRCh38]
Chr8:12608305..29302926 [GRCh37]
Chr8:12652676..29358845 [NCBI36]
Chr8:8p23.1-12		 pathogenic
GRCh38/hg38 8p22-q11.21(chr8:14940110-47929925)x3 copy number gain See cases [RCV000053635] Chr8:14940110..47929925 [GRCh38]
Chr8:14797619..48842485 [GRCh37]
Chr8:14841990..49005038 [NCBI36]
Chr8:8p22-q11.21		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:244417-145054775)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053604]|See cases [RCV000053604] Chr8:244417..145054775 [GRCh38]
Chr8:194417..146280161 [GRCh37]
Chr8:184417..146250965 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p23.3-12(chr8:96310-30614703)x3 copy number gain See cases [RCV000053599] Chr8:96310..30614703 [GRCh38]
Chr8:46310..30472220 [GRCh37]
Chr8:36310..30591762 [NCBI36]
Chr8:8p23.3-12		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000053602] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
NM_003844.3(TNFRSF10A):c.378C>T (p.Ser126=) single nucleotide variant Malignant melanoma [RCV000061778] Chr8:23212141 [GRCh38]
Chr8:23069654 [GRCh37]
Chr8:23125599 [NCBI36]
Chr8:8p21.3		 not provided
NM_003844.4(TNFRSF10A):c.355G>A (p.Gly119Ser) single nucleotide variant not provided [RCV000087209] Chr8:23212164 [GRCh38]
Chr8:23069677 [GRCh37]
Chr8:8p21.3		 uncertain significance
GRCh38/hg38 8p23.1-11.1(chr8:12609975-43673207)x3 copy number gain See cases [RCV000135786] Chr8:12609975..43673207 [GRCh38]
Chr8:12467484..43528350 [GRCh37]
Chr8:12511855..43647507 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12383584-43673207)x3 copy number gain See cases [RCV000135566] Chr8:12383584..43673207 [GRCh38]
Chr8:12241093..43528350 [GRCh37]
Chr8:12285464..43647507 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p23.1-11.21(chr8:12728904-40169194)x3 copy number gain See cases [RCV000136516] Chr8:12728904..40169194 [GRCh38]
Chr8:12586413..40026713 [GRCh37]
Chr8:12630784..40145870 [NCBI36]
Chr8:8p23.1-11.21		 pathogenic
GRCh38/hg38 8p23.3-21.2(chr8:241605-24656971)x3 copy number gain See cases [RCV000136026] Chr8:241605..24656971 [GRCh38]
Chr8:191605..24514484 [GRCh37]
Chr8:181605..24570374 [NCBI36]
Chr8:8p23.3-21.2		 pathogenic
GRCh38/hg38 8p23.3-21.3(chr8:241530-23198398)x3 copy number gain See cases [RCV000135967] Chr8:241530..23198398 [GRCh38]
Chr8:191530..23055911 [GRCh37]
Chr8:181530..23111856 [NCBI36]
Chr8:8p23.3-21.3		 pathogenic
GRCh38/hg38 8p23.1-12(chr8:12725750-30180521)x3 copy number gain See cases [RCV000136825] Chr8:12725750..30180521 [GRCh38]
Chr8:12583259..30038037 [GRCh37]
Chr8:12627630..30157579 [NCBI36]
Chr8:8p23.1-12		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12182421-43673207)x3 copy number gain See cases [RCV000137249] Chr8:12182421..43673207 [GRCh38]
Chr8:12039930..43528350 [GRCh37]
Chr8:12077339..43647507 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p23.1-12(chr8:12698495-35476082)x3 copy number gain See cases [RCV000138058] Chr8:12698495..35476082 [GRCh38]
Chr8:12556004..35333600 [GRCh37]
Chr8:12600375..35453142 [NCBI36]
Chr8:8p23.1-12		 pathogenic
GRCh38/hg38 8p21.3-21.2(chr8:22946697-25125997)x3 copy number gain See cases [RCV000137878] Chr8:22946697..25125997 [GRCh38]
Chr8:22804210..24983512 [GRCh37]
Chr8:22860155..25039429 [NCBI36]
Chr8:8p21.3-21.2		 uncertain significance
GRCh38/hg38 8p23.3-11.23(chr8:226452-38021728)x3 copy number gain See cases [RCV000137807] Chr8:226452..38021728 [GRCh38]
Chr8:176452..37879246 [GRCh37]
Chr8:166452..37998403 [NCBI36]
Chr8:8p23.3-11.23		 pathogenic|likely pathogenic
GRCh38/hg38 8p23.3-12(chr8:241605-31091074)x3 copy number gain See cases [RCV000138831] Chr8:241605..31091074 [GRCh38]
Chr8:191605..30948590 [GRCh37]
Chr8:181605..31068132 [NCBI36]
Chr8:8p23.3-12		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241605-145054781)x3 copy number gain See cases [RCV000138643] Chr8:241605..145054781 [GRCh38]
Chr8:191605..146280167 [GRCh37]
Chr8:181605..146250971 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p23.1-21.1(chr8:12382844-28625564)x3 copy number gain See cases [RCV000138244] Chr8:12382844..28625564 [GRCh38]
Chr8:12240353..28483081 [GRCh37]
Chr8:12284724..28539000 [NCBI36]
Chr8:8p23.1-21.1		 pathogenic
GRCh38/hg38 8p23.1-11.22(chr8:7141697-38695546)x3 copy number gain See cases [RCV000139891] Chr8:7141697..38695546 [GRCh38]
Chr8:6999219..38553064 [GRCh37]
Chr8:6986629..38672221 [NCBI36]
Chr8:8p23.1-11.22		 pathogenic
GRCh38/hg38 8p23.1-11.22(chr8:12729023-39235934)x3 copy number gain See cases [RCV000139770] Chr8:12729023..39235934 [GRCh38]
Chr8:12586532..39093453 [GRCh37]
Chr8:12630903..39212610 [NCBI36]
Chr8:8p23.1-11.22		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12646123-43686843)x3 copy number gain See cases [RCV000139796] Chr8:12646123..43686843 [GRCh38]
Chr8:12503632..43541986 [GRCh37]
Chr8:12548003..43661143 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p23.1-11.23(chr8:11851113-37216333)x3 copy number gain See cases [RCV000139549] Chr8:11851113..37216333 [GRCh38]
Chr8:11708622..37073851 [GRCh37]
Chr8:11746031..37193009 [NCBI36]
Chr8:8p23.1-11.23		 pathogenic
GRCh38/hg38 8p23.3-12(chr8:226452-34491890)x3 copy number gain See cases [RCV000141410] Chr8:226452..34491890 [GRCh38]
Chr8:176452..34349408 [GRCh37]
Chr8:166452..34468950 [NCBI36]
Chr8:8p23.3-12		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:208048-145070385)x3 copy number gain See cases [RCV000141808] Chr8:208048..145070385 [GRCh38]
Chr8:158048..146295771 [GRCh37]
Chr8:148048..146266575 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p23.1-12(chr8:12383584-29033946)x1 copy number loss See cases [RCV000142516] Chr8:12383584..29033946 [GRCh38]
Chr8:12241093..28891463 [GRCh37]
Chr8:12285464..28947382 [NCBI36]
Chr8:8p23.1-12		 pathogenic
GRCh38/hg38 8p21.3-q24.3(chr8:21291522-145070385)x3 copy number gain See cases [RCV000142021] Chr8:21291522..145070385 [GRCh38]
Chr8:21149033..146295771 [GRCh37]
Chr8:21193313..146266575 [NCBI36]
Chr8:8p21.3-q24.3		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:226452-145068712)x3 copy number gain See cases [RCV000142858] Chr8:226452..145068712 [GRCh38]
Chr8:176452..146294098 [GRCh37]
Chr8:166452..146264902 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p22-12(chr8:18972996-33619264)x1 copy number loss See cases [RCV000142747] Chr8:18972996..33619264 [GRCh38]
Chr8:18830506..33476782 [GRCh37]
Chr8:18874786..33596324 [NCBI36]
Chr8:8p22-12		 pathogenic
GRCh38/hg38 8p23.3-q24.3(chr8:241530-145054634)x3 copy number gain See cases [RCV000148092] Chr8:241530..145054634 [GRCh38]
Chr8:191530..146280020 [GRCh37]
Chr8:181530..146250824 [NCBI36]
Chr8:8p23.3-q24.3		 pathogenic
GRCh38/hg38 8p23.1-11.21(chr8:12633490-40685533)x3 copy number gain See cases [RCV000143508] Chr8:12633490..40685533 [GRCh38]
Chr8:12490999..40543052 [GRCh37]
Chr8:12535370..40662209 [NCBI36]
Chr8:8p23.1-11.21		 pathogenic
GRCh38/hg38 8p23.1-11.21(chr8:12609975-42085703)x3 copy number gain See cases [RCV000148249] Chr8:12609975..42085703 [GRCh38]
Chr8:12467484..41943221 [GRCh37]
Chr8:12511855..42062378 [NCBI36]
Chr8:8p23.1-11.21		 pathogenic
GRCh38/hg38 8p23.1-11.1(chr8:12728904-43673207)x3 copy number gain See cases [RCV000148237] Chr8:12728904..43673207 [GRCh38]
Chr8:12586413..43528350 [GRCh37]
Chr8:12630784..43647507 [NCBI36]
Chr8:8p23.1-11.1		 pathogenic
GRCh38/hg38 8p23.2-21.1(chr8:2475295-27504279)x1 copy number loss See cases [RCV000148252] Chr8:2475295..27504279 [GRCh38]
Chr8:2292235..27361796 [GRCh37]
Chr8:2121457..27417713 [NCBI36]
Chr8:8p23.2-21.1		 pathogenic
GRCh37/hg19 8p21.3-12(chr8:20478546-28986438)x3 copy number gain See cases [RCV000203434] Chr8:20478546..28986438 [GRCh37]
Chr8:8p21.3-12		 pathogenic
GRCh37/hg19 8p23.1-11.22(chr8:12528482-39593802)x3 copy number gain See cases [RCV000511325] Chr8:12528482..39593802 [GRCh37]
Chr8:8p23.1-11.22		 pathogenic
GRCh37/hg19 8p23.1-21.2(chr8:12580132-26774307)x3 copy number gain See cases [RCV000239945] Chr8:12580132..26774307 [GRCh37]
Chr8:8p23.1-21.2		 pathogenic
GRCh37/hg19 8p23.3-12(chr8:158048-30262760)x3 copy number gain See cases [RCV000449225] Chr8:158048..30262760 [GRCh37]
Chr8:8p23.3-12		 pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158991-146280828)x3 copy number gain See cases [RCV000447507] Chr8:158991..146280828 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8p22-21.2(chr8:13091530-24483615) copy number loss See cases [RCV000447428] Chr8:13091530..24483615 [GRCh37]
Chr8:8p22-21.2		 pathogenic
GRCh37/hg19 8p23.3-11.1(chr8:158048-43786723)x3 copy number gain See cases [RCV000447909] Chr8:158048..43786723 [GRCh37]
Chr8:8p23.3-11.1		 pathogenic
GRCh37/hg19 8p23.1-11.1(chr8:12580132-43388233)x3 copy number gain See cases [RCV000447913] Chr8:12580132..43388233 [GRCh37]
Chr8:8p23.1-11.1		 pathogenic
GRCh37/hg19 8p22-12(chr8:16992973-32612724)x1 copy number loss not provided [RCV000509389] Chr8:16992973..32612724 [GRCh37]
Chr8:8p22-12		 not provided
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771) copy number gain See cases [RCV000510234] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8p23.1-12(chr8:12528482-33684786)x3 copy number gain See cases [RCV000510571] Chr8:12528482..33684786 [GRCh37]
Chr8:8p23.1-12		 pathogenic
GRCh37/hg19 8p23.1-11.1(chr8:11935023-43824035)x3 copy number gain See cases [RCV000511028] Chr8:11935023..43824035 [GRCh37]
Chr8:8p23.1-11.1		 pathogenic
GRCh37/hg19 8p23.1-12(chr8:11945855-34875355)x3 copy number gain See cases [RCV000510899] Chr8:11945855..34875355 [GRCh37]
Chr8:8p23.1-12		 pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158049-146295771)x3 copy number gain See cases [RCV000511095] Chr8:158049..146295771 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8p21.3(chr8:22381361-23226751)x3 copy number gain See cases [RCV000510870] Chr8:22381361..23226751 [GRCh37]
Chr8:8p21.3		 likely benign
Single allele duplication not provided [RCV000768452] Chr8:12546855..35816855 [GRCh37]
Chr8:8p23.1-12		 likely pathogenic
NM_003844.4(TNFRSF10A):c.1019C>T (p.Pro340Leu) single nucleotide variant not specified [RCV004288767] Chr8:23197200 [GRCh38]
Chr8:23054713 [GRCh37]
Chr8:8p21.3		 uncertain significance
NM_003844.4(TNFRSF10A):c.1196C>G (p.Ala399Gly) single nucleotide variant not specified [RCV004310434] Chr8:23191905 [GRCh38]
Chr8:23049418 [GRCh37]
Chr8:8p21.3		 uncertain significance
NM_003844.4(TNFRSF10A):c.397C>T (p.Pro133Ser) single nucleotide variant not specified [RCV004311446] Chr8:23212122 [GRCh38]
Chr8:23069635 [GRCh37]
Chr8:8p21.3		 uncertain significance
NM_003844.4(TNFRSF10A):c.928G>T (p.Val310Phe) single nucleotide variant not specified [RCV004302916] Chr8:23199352 [GRCh38]
Chr8:23056865 [GRCh37]
Chr8:8p21.3		 uncertain significance
GRCh37/hg19 8p23.1-21.2(chr8:12580104-25947329) copy number gain Autism [RCV000626542] Chr8:12580104..25947329 [GRCh37]
Chr8:8p23.1-21.2		 pathogenic
GRCh37/hg19 8p23.1-q24.3(chr8:12490999-146295771)x3 copy number gain See cases [RCV000512169] Chr8:12490999..146295771 [GRCh37]
Chr8:8p23.1-q24.3		 pathogenic
GRCh37/hg19 8p23.1-21.2(chr8:8770948-27079636)x3 copy number gain not provided [RCV000683041] Chr8:8770948..27079636 [GRCh37]
Chr8:8p23.1-21.2		 pathogenic
GRCh37/hg19 8p23.1-12(chr8:12552775-35935825)x3 copy number gain not provided [RCV000683043] Chr8:12552775..35935825 [GRCh37]
Chr8:8p23.1-12		 pathogenic
GRCh37/hg19 8p23.3-21.2(chr8:1825200-24533193)x3 copy number gain not provided [RCV000683042] Chr8:1825200..24533193 [GRCh37]
Chr8:8p23.3-21.2		 pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:164984-146293414)x3 copy number gain not provided [RCV000747254] Chr8:164984..146293414 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:10213-146293414)x3 copy number gain not provided [RCV000747248] Chr8:10213..146293414 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8p23.1-12(chr8:12556004-34374150)x3 copy number gain not provided [RCV000762735] Chr8:12556004..34374150 [GRCh37]
Chr8:8p23.1-12		 likely pathogenic
NM_003844.4(TNFRSF10A):c.703+12A>G single nucleotide variant not provided [RCV001645141] Chr8:23200675 [GRCh38]
Chr8:23058188 [GRCh37]
Chr8:8p21.3		 benign
NM_003844.4(TNFRSF10A):c.1406G>T (p.Ter469Leu) single nucleotide variant not provided [RCV000966201] Chr8:23191695 [GRCh38]
Chr8:23049208 [GRCh37]
Chr8:8p21.3		 benign
NM_003844.4(TNFRSF10A):c.891C>T (p.Asn297=) single nucleotide variant not provided [RCV000884440] Chr8:23199389 [GRCh38]
Chr8:23056902 [GRCh37]
Chr8:8p21.3		 benign
NM_003844.4(TNFRSF10A):c.206G>C (p.Arg69Pro) single nucleotide variant not provided [RCV000905321] Chr8:23224856 [GRCh38]
Chr8:23082369 [GRCh37]
Chr8:8p21.3		 benign
NM_003844.4(TNFRSF10A):c.1087+10T>G single nucleotide variant not provided [RCV000904660] Chr8:23197122 [GRCh38]
Chr8:23054635 [GRCh37]
Chr8:8p21.3		 benign
NM_003844.4(TNFRSF10A):c.889A>C (p.Asn297His) single nucleotide variant not provided [RCV000904661] Chr8:23199391 [GRCh38]
Chr8:23056904 [GRCh37]
Chr8:8p21.3		 benign
NM_003844.4(TNFRSF10A):c.465C>A (p.Thr155=) single nucleotide variant not provided [RCV000888490] Chr8:23202700 [GRCh38]
Chr8:23060213 [GRCh37]
Chr8:8p21.3		 likely benign
NM_003844.4(TNFRSF10A):c.517+6G>C single nucleotide variant not provided [RCV000955184] Chr8:23202642 [GRCh38]
Chr8:23060155 [GRCh37]
Chr8:8p21.3		 likely benign
NM_003844.4(TNFRSF10A):c.1087+7G>A single nucleotide variant not provided [RCV000965071] Chr8:23197125 [GRCh38]
Chr8:23054638 [GRCh37]
Chr8:8p21.3		 benign
GRCh37/hg19 8p21.3-21.2(chr8:21662847-24199218)x1 copy number loss not provided [RCV000849161] Chr8:21662847..24199218 [GRCh37]
Chr8:8p21.3-21.2		 pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not provided [RCV000848478] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8p21.3-21.2(chr8:22442548-27369334)x1 copy number loss not provided [RCV000847074] Chr8:22442548..27369334 [GRCh37]
Chr8:8p21.3-21.2		 pathogenic
NM_003844.4(TNFRSF10A):c.57T>A (p.Asn19Lys) single nucleotide variant not specified [RCV004292023] Chr8:23225005 [GRCh38]
Chr8:23082518 [GRCh37]
Chr8:8p21.3		 uncertain significance
NM_003844.4(TNFRSF10A):c.683A>C (p.Glu228Ala) single nucleotide variant not provided [RCV001650796] Chr8:23200707 [GRCh38]
Chr8:23058220 [GRCh37]
Chr8:8p21.3		 benign
NM_003844.4(TNFRSF10A):c.933T>C (p.Ser311=) single nucleotide variant not provided [RCV000910372] Chr8:23199347 [GRCh38]
Chr8:23056860 [GRCh37]
Chr8:8p21.3		 benign
NM_003844.4(TNFRSF10A):c.906C>T (p.Asn302=) single nucleotide variant not provided [RCV000965072] Chr8:23199374 [GRCh38]
Chr8:23056887 [GRCh37]
Chr8:8p21.3		 benign
NM_003844.4(TNFRSF10A):c.306+5G>C single nucleotide variant not provided [RCV000958133] Chr8:23224751 [GRCh38]
Chr8:23082264 [GRCh37]
Chr8:8p21.3		 benign
NM_003844.4(TNFRSF10A):c.717T>C (p.Asn239=) single nucleotide variant not provided [RCV000933889] Chr8:23200587 [GRCh38]
Chr8:23058100 [GRCh37]
Chr8:8p21.3		 likely benign
NM_003844.4(TNFRSF10A):c.1197T>C (p.Ala399=) single nucleotide variant not provided [RCV000933925] Chr8:23191904 [GRCh38]
Chr8:23049417 [GRCh37]
Chr8:8p21.3		 likely benign
NM_003844.4(TNFRSF10A):c.1341C>G (p.Leu447=) single nucleotide variant not provided [RCV000956574] Chr8:23191760 [GRCh38]
Chr8:23049273 [GRCh37]
Chr8:8p21.3		 benign
GRCh37/hg19 8p23.1-12(chr8:12528482-29886483)x3 copy number gain not provided [RCV001260030] Chr8:12528482..29886483 [GRCh37]
Chr8:8p23.1-12		 likely pathogenic
GRCh37/hg19 8p23.3-11.1(chr8:176814-43396776) copy number gain Abnormal fetal cardiovascular morphology [RCV001291977] Chr8:176814..43396776 [GRCh37]
Chr8:8p23.3-11.1		 pathogenic
NC_000008.10:g.(?_21900440)_(23564111_?)dup duplication Conotruncal heart malformations [RCV003107885]|not provided [RCV001928022] Chr8:21900440..23564111 [GRCh37]
Chr8:8p21.3-21.2		 uncertain significance|no classifications from unflagged records
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771) copy number gain Polydactyly [RCV002280629] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
GRCh37/hg19 8p21.3-21.2(chr8:19779604-26531980)x4 copy number gain not provided [RCV002279745] Chr8:19779604..26531980 [GRCh37]
Chr8:8p21.3-21.2		 pathogenic
Single allele complex See cases [RCV002292428] Chr8:6999114..11935023 [GRCh37]
Chr8:8p23.3-11.21		 pathogenic
GRCh37/hg19 8p23.3-12(chr8:158048-30187456)x1 copy number loss See cases [RCV002286343] Chr8:158048..30187456 [GRCh37]
Chr8:8p23.3-12		 pathogenic
Single allele complex 8p inverted duplication/deletion syndrome [RCV002280753] Chr8:158048..43019304 [GRCh37]
Chr8:8p23.3-11.21		 pathogenic
NM_003844.4(TNFRSF10A):c.420A>C (p.Glu140Asp) single nucleotide variant not specified [RCV004132249] Chr8:23202745 [GRCh38]
Chr8:23060258 [GRCh37]
Chr8:8p21.3		 uncertain significance
NM_003844.4(TNFRSF10A):c.1135T>C (p.Ser379Pro) single nucleotide variant not specified [RCV004162184] Chr8:23191966 [GRCh38]
Chr8:23049479 [GRCh37]
Chr8:8p21.3		 uncertain significance
NM_003844.4(TNFRSF10A):c.1262G>A (p.Arg421Gln) single nucleotide variant not specified [RCV004205045] Chr8:23191839 [GRCh38]
Chr8:23049352 [GRCh37]
Chr8:8p21.3		 uncertain significance
NM_003844.4(TNFRSF10A):c.587G>A (p.Arg196Gln) single nucleotide variant not specified [RCV004212078] Chr8:23201850 [GRCh38]
Chr8:23059363 [GRCh37]
Chr8:8p21.3		 uncertain significance
NM_003844.4(TNFRSF10A):c.305A>C (p.Gln102Pro) single nucleotide variant not specified [RCV004098653] Chr8:23224757 [GRCh38]
Chr8:23082270 [GRCh37]
Chr8:8p21.3		 uncertain significance
NM_003844.4(TNFRSF10A):c.110T>G (p.Val37Gly) single nucleotide variant not specified [RCV004184332] Chr8:23224952 [GRCh38]
Chr8:23082465 [GRCh37]
Chr8:8p21.3		 uncertain significance
NM_003844.4(TNFRSF10A):c.1070G>A (p.Gly357Asp) single nucleotide variant not specified [RCV004210595] Chr8:23197149 [GRCh38]
Chr8:23054662 [GRCh37]
Chr8:8p21.3		 uncertain significance
NM_003844.4(TNFRSF10A):c.475A>G (p.Asn159Asp) single nucleotide variant not specified [RCV004219081] Chr8:23202690 [GRCh38]
Chr8:23060203 [GRCh37]
Chr8:8p21.3		 uncertain significance
NM_003844.4(TNFRSF10A):c.1301G>C (p.Arg434Thr) single nucleotide variant not specified [RCV004178582] Chr8:23191800 [GRCh38]
Chr8:23049313 [GRCh37]
Chr8:8p21.3		 uncertain significance
NM_003844.4(TNFRSF10A):c.21A>T (p.Arg7Ser) single nucleotide variant not specified [RCV004117737] Chr8:23225041 [GRCh38]
Chr8:23082554 [GRCh37]
Chr8:8p21.3		 uncertain significance
NM_003844.4(TNFRSF10A):c.109G>A (p.Val37Met) single nucleotide variant not specified [RCV004109168] Chr8:23224953 [GRCh38]
Chr8:23082466 [GRCh37]
Chr8:8p21.3		 uncertain significance
NM_003844.4(TNFRSF10A):c.813C>G (p.Asp271Glu) single nucleotide variant not specified [RCV004101166] Chr8:23199904 [GRCh38]
Chr8:23057417 [GRCh37]
Chr8:8p21.3		 uncertain significance
NM_003844.4(TNFRSF10A):c.845G>A (p.Arg282His) single nucleotide variant not specified [RCV004186889] Chr8:23199435 [GRCh38]
Chr8:23056948 [GRCh37]
Chr8:8p21.3		 uncertain significance
NM_003844.4(TNFRSF10A):c.562T>A (p.Cys188Ser) single nucleotide variant not specified [RCV004182975] Chr8:23201875 [GRCh38]
Chr8:23059388 [GRCh37]
Chr8:8p21.3		 uncertain significance
NM_003844.4(TNFRSF10A):c.650A>C (p.Lys217Thr) single nucleotide variant not specified [RCV004101237] Chr8:23200740 [GRCh38]
Chr8:23058253 [GRCh37]
Chr8:8p21.3		 uncertain significance
NM_003844.4(TNFRSF10A):c.1143C>A (p.Asp381Glu) single nucleotide variant not specified [RCV004099587] Chr8:23191958 [GRCh38]
Chr8:23049471 [GRCh37]
Chr8:8p21.3		 uncertain significance
NM_003844.4(TNFRSF10A):c.295G>T (p.Val99Phe) single nucleotide variant not specified [RCV004203812] Chr8:23224767 [GRCh38]
Chr8:23082280 [GRCh37]
Chr8:8p21.3		 uncertain significance
NM_003844.4(TNFRSF10A):c.92C>A (p.Ala31Glu) single nucleotide variant not specified [RCV004274791] Chr8:23224970 [GRCh38]
Chr8:23082483 [GRCh37]
Chr8:8p21.3		 uncertain significance
NM_003844.4(TNFRSF10A):c.652G>T (p.Val218Phe) single nucleotide variant not specified [RCV004250646] Chr8:23200738 [GRCh38]
Chr8:23058251 [GRCh37]
Chr8:8p21.3		 uncertain significance
GRCh37/hg19 8p21.3-21.2(chr8:21925038-26372195)x1 copy number loss not provided [RCV003223292] Chr8:21925038..26372195 [GRCh37]
Chr8:8p21.3-21.2		 likely pathogenic
NM_003844.4(TNFRSF10A):c.863G>T (p.Gly288Val) single nucleotide variant not specified [RCV004312239] Chr8:23199417 [GRCh38]
Chr8:23056930 [GRCh37]
Chr8:8p21.3		 uncertain significance
GRCh38/hg38 8p23.1-12(chr8:12721809-30183737)x1 copy number loss Microcephaly [RCV003327707] Chr8:12721809..30183737 [GRCh38]
Chr8:8p23.1-12		 pathogenic
GRCh38/hg38 8p23.3-21.2(chr8:449893-23854904)x1 copy number loss Neurodevelopmental disorder [RCV003327729] Chr8:449893..23854904 [GRCh38]
Chr8:8p23.3-21.2		 pathogenic
NM_003844.4(TNFRSF10A):c.928G>A (p.Val310Ile) single nucleotide variant not specified [RCV004344672] Chr8:23199352 [GRCh38]
Chr8:23056865 [GRCh37]
Chr8:8p21.3		 likely benign
NM_003844.4(TNFRSF10A):c.536C>T (p.Pro179Leu) single nucleotide variant not specified [RCV004354321] Chr8:23201901 [GRCh38]
Chr8:23059414 [GRCh37]
Chr8:8p21.3		 uncertain significance
GRCh37/hg19 8p23.1-11.22(chr8:12560782-38748763)x3 copy number gain not provided [RCV003484724] Chr8:12560782..38748763 [GRCh37]
Chr8:8p23.1-11.22		 pathogenic
GRCh37/hg19 8p23.1-11.23(chr8:11945856-37902453)x3 copy number gain not provided [RCV003484722] Chr8:11945856..37902453 [GRCh37]
Chr8:8p23.1-11.23		 pathogenic
Single allele duplication not provided [RCV003448693] Chr8:12530550..43483193 [GRCh37]
Chr8:8p23.1-11.1		 pathogenic
GRCh37/hg19 8p23.2-11.21(chr8:2201405-41723095)x3 copy number gain not provided [RCV003484713] Chr8:2201405..41723095 [GRCh37]
Chr8:8p23.2-11.21		 pathogenic
GRCh37/hg19 8p22-11.1(chr8:14240573-43824035)x3 copy number gain not provided [RCV003484725] Chr8:14240573..43824035 [GRCh37]
Chr8:8p22-11.1		 pathogenic
GRCh37/hg19 8p23.1-21.1(chr8:12490999-28150620)x1 copy number loss not provided [RCV003483018] Chr8:12490999..28150620 [GRCh37]
Chr8:8p23.1-21.1		 pathogenic
NM_003844.4(TNFRSF10A):c.456G>A (p.Val152=) single nucleotide variant not provided [RCV003436806] Chr8:23202709 [GRCh38]
Chr8:23060222 [GRCh37]
Chr8:8p21.3		 likely benign
GRCh37/hg19 8p23.3-11.21(chr8:158048-41600696)x3 copy number gain not specified [RCV003986756] Chr8:158048..41600696 [GRCh37]
Chr8:8p23.3-11.21		 pathogenic
GRCh37/hg19 8p21.3-11.1(chr8:20136266-43786723)x3 copy number gain not specified [RCV003986767] Chr8:20136266..43786723 [GRCh37]
Chr8:8p21.3-11.1		 pathogenic
GRCh37/hg19 8p23.3-q24.3(chr8:158048-146295771)x3 copy number gain not specified [RCV003986742] Chr8:158048..146295771 [GRCh37]
Chr8:8p23.3-q24.3		 pathogenic
NM_003844.4(TNFRSF10A):c.1213G>A (p.Gly405Arg) single nucleotide variant not specified [RCV004473104] Chr8:23191888 [GRCh38]
Chr8:23049401 [GRCh37]
Chr8:8p21.3		 uncertain significance
NM_003844.4(TNFRSF10A):c.628G>A (p.Gly210Arg) single nucleotide variant not specified [RCV004473110] Chr8:23201809 [GRCh38]
Chr8:23059322 [GRCh37]
Chr8:8p21.3		 uncertain significance
NM_003844.4(TNFRSF10A):c.236C>T (p.Ala79Val) single nucleotide variant not specified [RCV004473108] Chr8:23224826 [GRCh38]
Chr8:23082339 [GRCh37]
Chr8:8p21.3		 uncertain significance
NM_003844.4(TNFRSF10A):c.142C>G (p.Arg48Gly) single nucleotide variant not specified [RCV004473106] Chr8:23224920 [GRCh38]
Chr8:23082433 [GRCh37]
Chr8:8p21.3		 uncertain significance
NM_003844.4(TNFRSF10A):c.1086G>C (p.Glu362Asp) single nucleotide variant not specified [RCV004473101] Chr8:23197133 [GRCh38]
Chr8:23054646 [GRCh37]
Chr8:8p21.3		 uncertain significance
NM_003844.4(TNFRSF10A):c.1123G>A (p.Val375Met) single nucleotide variant not specified [RCV004473102] Chr8:23191978 [GRCh38]
Chr8:23049491 [GRCh37]
Chr8:8p21.3		 uncertain significance
NM_003844.4(TNFRSF10A):c.1195G>A (p.Ala399Thr) single nucleotide variant not specified [RCV004473103] Chr8:23191906 [GRCh38]
Chr8:23049419 [GRCh37]
Chr8:8p21.3		 uncertain significance
NM_003844.4(TNFRSF10A):c.1313G>A (p.Arg438Lys) single nucleotide variant not specified [RCV004473105] Chr8:23191788 [GRCh38]
Chr8:23049301 [GRCh37]
Chr8:8p21.3		 uncertain significance
NM_003844.4(TNFRSF10A):c.188G>A (p.Gly63Glu) single nucleotide variant not specified [RCV004473107] Chr8:23224874 [GRCh38]
Chr8:23082387 [GRCh37]
Chr8:8p21.3		 uncertain significance
NM_003844.4(TNFRSF10A):c.281T>C (p.Phe94Ser) single nucleotide variant not specified [RCV004473109] Chr8:23224781 [GRCh38]
Chr8:23082294 [GRCh37]
Chr8:8p21.3		 uncertain significance
NM_003844.4(TNFRSF10A):c.633C>G (p.Cys211Trp) single nucleotide variant not specified [RCV004473111] Chr8:23200757 [GRCh38]
Chr8:23058270 [GRCh37]
Chr8:8p21.3		 uncertain significance
NM_003844.4(TNFRSF10A):c.853C>G (p.Leu285Val) single nucleotide variant not specified [RCV004473112] Chr8:23199427 [GRCh38]
Chr8:23056940 [GRCh37]
Chr8:8p21.3		 uncertain significance
NM_003844.4(TNFRSF10A):c.85G>A (p.Ala29Thr) single nucleotide variant not specified [RCV004473113] Chr8:23224977 [GRCh38]
Chr8:23082490 [GRCh37]
Chr8:8p21.3		 uncertain significance
NM_003844.4(TNFRSF10A):c.538T>A (p.Cys180Ser) single nucleotide variant not specified [RCV004687004] Chr8:23201899 [GRCh38]
Chr8:23059412 [GRCh37]
Chr8:8p21.3		 uncertain significance
NM_003844.4(TNFRSF10A):c.1134C>G (p.Asp378Glu) single nucleotide variant not specified [RCV004687005] Chr8:23191967 [GRCh38]
Chr8:23049480 [GRCh37]
Chr8:8p21.3		 uncertain significance
NM_003844.4(TNFRSF10A):c.854T>A (p.Leu285His) single nucleotide variant not specified [RCV004680062] Chr8:23199426 [GRCh38]
Chr8:23056939 [GRCh37]
Chr8:8p21.3		 uncertain significance
NM_003844.4(TNFRSF10A):c.614G>A (p.Arg205Gln) single nucleotide variant not specified [RCV004680058] Chr8:23201823 [GRCh38]
Chr8:23059336 [GRCh37]
Chr8:8p21.3		 likely benign
NM_003844.4(TNFRSF10A):c.95C>A (p.Ala32Asp) single nucleotide variant not specified [RCV004680060] Chr8:23224967 [GRCh38]
Chr8:23082480 [GRCh37]
Chr8:8p21.3		 uncertain significance
NM_003844.4(TNFRSF10A):c.1183G>C (p.Asp395His) single nucleotide variant not specified [RCV004680061] Chr8:23191918 [GRCh38]
Chr8:23049431 [GRCh37]
Chr8:8p21.3		 uncertain significance
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR25hsa-miR-25-3pOncomiRDBexternal_infoNANA21953056

Predicted Target Of
Summary Value
Count of predictions:1183
Count of miRNA genes:690
Interacting mature miRNAs:773
Transcripts:ENST00000221132, ENST00000519862, ENST00000524158
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1298482BP2_HBlood pressure QTL 2 (human)1.8Blood pressurediastolic8695325632953256Human
407357908GWAS1006884_Hserum gamma-glutamyl transferase measurement QTL GWAS1006884 (human)5e-08serum gamma-glutamyl transferase measurementserum gamma-glutamyltransferase activity level (CMO:0002241)82322262223222623Human
407003108GWAS652084_Hmonocyte count QTL GWAS652084 (human)4e-17monocyte quantity (VT:0000223)blood monocyte count (CMO:0000032)82322331623223317Human
1558703SCL6_HSerum cholesterol level QTL 1 (human)1.2Lipid levelHDL cholesterol81246863538468635Human
407389856GWAS1038832_Htumor necrosis factor receptor superfamily member 10A measurement QTL GWAS1038832 (human)2e-18tumor necrosis factor receptor superfamily member 10A measurement82321077323210774Human
407344492GWAS993468_Htumor necrosis factor receptor superfamily member 10A measurement QTL GWAS993468 (human)9e-20tumor necrosis factor receptor superfamily member 10A measurement82319594723195948Human
407376149GWAS1025125_Htumor necrosis factor receptor superfamily member 10A measurement QTL GWAS1025125 (human)8e-67tumor necrosis factor receptor superfamily member 10A measurement82321077323210774Human
407389190GWAS1038166_Hserum gamma-glutamyl transferase measurement QTL GWAS1038166 (human)1e-10serum gamma-glutamyl transferase measurementserum gamma-glutamyltransferase activity level (CMO:0002241)82322262223222623Human

Markers in Region
TNFRSF10A_2005  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37823,048,803 - 23,049,519UniSTSGRCh37
Build 36823,104,748 - 23,105,464RGDNCBI36
Celera822,011,402 - 22,012,118RGD
HuRef821,594,779 - 21,595,495UniSTS
RH67885  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37823,048,557 - 23,048,798UniSTSGRCh37
Build 36823,104,502 - 23,104,743RGDNCBI36
Celera822,011,156 - 22,011,397RGD
Cytogenetic Map8p21UniSTS
HuRef821,594,533 - 21,594,774UniSTS
GeneMap99-GB4 RH Map898.05UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2439 2788 2252 4962 1725 2348 6 623 1950 464 2264 7302 6469 52 3728 1 852 1744 1615 174 1

Sequence


Ensembl Acc Id: ENST00000221132   ⟹   ENSP00000221132
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl823,190,452 - 23,225,102 (-)Ensembl
Ensembl Acc Id: ENST00000519862
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl823,191,814 - 23,197,273 (-)Ensembl
Ensembl Acc Id: ENST00000524158   ⟹   ENSP00000428884
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl823,199,886 - 23,224,600 (-)Ensembl
Ensembl Acc Id: ENST00000613472   ⟹   ENSP00000480778
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl823,191,649 - 23,225,061 (-)Ensembl
RefSeq Acc Id: NM_003844   ⟹   NP_003835
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38823,190,452 - 23,225,102 (-)NCBI
GRCh37823,048,970 - 23,082,680 (-)ENTREZGENE
Build 36823,104,915 - 23,138,584 (-)NCBI Archive
HuRef821,594,946 - 21,628,637 (-)ENTREZGENE
CHM1_1823,251,086 - 23,284,807 (-)NCBI
T2T-CHM13v2.0823,465,337 - 23,499,970 (-)NCBI
Sequence:
RefSeq Acc Id: NP_003835   ⟸   NM_003844
- UniProtKB: Q53Y72 (UniProtKB/Swiss-Prot),   A8K5I4 (UniProtKB/Swiss-Prot),   Q96E62 (UniProtKB/Swiss-Prot),   O00220 (UniProtKB/Swiss-Prot),   C1K3N4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000480778   ⟸   ENST00000613472
Ensembl Acc Id: ENSP00000221132   ⟸   ENST00000221132
Ensembl Acc Id: ENSP00000428884   ⟸   ENST00000524158
Protein Domains
Death   TNFR-Cys

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O00220-F1-model_v2 AlphaFold O00220 1-468 view protein structure

Promoters
RGD ID:6807086
Promoter ID:HG_KWN:60918
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000215133,   UC003XDB.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36823,137,391 - 23,138,682 (-)MPROMDB
RGD ID:7212859
Promoter ID:EPDNEW_H12176
Type:initiation region
Name:TNFRSF10A_1
Description:TNF receptor superfamily member 10a
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H12178  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38823,225,099 - 23,225,159EPDNEW
RGD ID:7212863
Promoter ID:EPDNEW_H12178
Type:initiation region
Name:TNFRSF10A_2
Description:TNF receptor superfamily member 10a
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H12176  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38823,225,390 - 23,225,450EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:11904 AgrOrtholog
COSMIC TNFRSF10A COSMIC
Ensembl Genes ENSG00000104689 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000221132 ENTREZGENE
  ENST00000221132.8 UniProtKB/Swiss-Prot
  ENST00000524158.5 UniProtKB/TrEMBL
  ENST00000613472.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tumor Necrosis Factor Receptor, subunit A, domain 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000104689 GTEx
HGNC ID HGNC:11904 ENTREZGENE
Human Proteome Map TNFRSF10A Human Proteome Map
InterPro DEATH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Death_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFR/NGFR_Cys_rich_reg UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFR_10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFRSF10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFRSF10_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFRSF10A/B_death UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:8797 UniProtKB/Swiss-Prot
NCBI Gene 8797 ENTREZGENE
OMIM 603611 OMIM
PANTHER TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Death UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFR_c6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA36597 PharmGKB
PIRSF CD261_antigen UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS TNFACTORR10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE DEATH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFR_NGFR_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFR_NGFR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DEATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNFR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNF receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A8K5I4 ENTREZGENE
  C1K3N4 ENTREZGENE, UniProtKB/TrEMBL
  E5RFH1_HUMAN UniProtKB/TrEMBL
  F8U8C0_HUMAN UniProtKB/TrEMBL
  L8EA63_HUMAN UniProtKB/TrEMBL
  O00220 ENTREZGENE
  Q53Y72 ENTREZGENE
  Q96E62 ENTREZGENE
  TR10A_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary A8K5I4 UniProtKB/Swiss-Prot
  Q53Y72 UniProtKB/Swiss-Prot
  Q96E62 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-30 TNFRSF10A  TNF receptor superfamily member 10a  TNFRSF10A  tumor necrosis factor receptor superfamily member 10a  Symbol and/or name change 5135510 APPROVED
2015-11-24 TNFRSF10A  tumor necrosis factor receptor superfamily member 10a  TNFRSF10A  tumor necrosis factor receptor superfamily, member 10a  Symbol and/or name change 5135510 APPROVED