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Gene: TNFRSF10A (TNF receptor superfamily member 10a) Homo sapiens
Symbol: TNFRSF10A
Name: TNF receptor superfamily member 10a
Description: Exhibits identical protein binding activity; protease binding activity; and transcription factor binding activity. Involved in TRAIL-activated apoptotic signaling pathway and cellular response to mechanical stimulus. Localizes to several cellular components, including Golgi apparatus; cell surface; and membrane raft. Implicated in cervical cancer; head and neck squamous cell carcinoma; hematologic cancer (multiple); and urinary system cancer (multiple). Biomarker of breast ductal carcinoma and renal cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: APO2; CD261; cytotoxic TRAIL receptor; death receptor 4; DR4; MGC9365; TNF-related apoptosis inducing ligand receptor 1; TNF-related apoptosis-inducing ligand receptor 1; TRAIL receptor 1; TRAIL-R1; TRAILR-1; TRAILR1; tumor necrosis factor receptor superfamily member 10A; tumor necrosis factor receptor superfamily member 10a variant 2; tumor necrosis factor receptor superfamily, member 10a
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl823,190,452 - 23,225,102 (-)EnsemblGRCh38hg38GRCh38
GRCh38823,190,452 - 23,225,102 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37823,048,970 - 23,082,680 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36823,104,915 - 23,138,584 (-)NCBINCBI36hg18NCBI36
Build 34823,104,915 - 23,138,584NCBI
Celera822,011,569 - 22,045,255 (-)NCBI
Cytogenetic Map8p21.3NCBI
HuRef821,594,946 - 21,628,637 (-)NCBIHuRef
CHM1_1823,251,086 - 23,284,807 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TNFRSF10A
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1317580
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2020-03-31
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.