TIMP1 (TIMP metallopeptidase inhibitor 1) - Rat Genome Database

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Gene: TIMP1 (TIMP metallopeptidase inhibitor 1) Homo sapiens
Analyze
Symbol: TIMP1
Name: TIMP metallopeptidase inhibitor 1
RGD ID: 1347215
HGNC Page HGNC:11820
Description: Enables cytokine activity; metalloendopeptidase inhibitor activity; and zinc ion binding activity. Involved in several processes, including cellular response to UV-A; negative regulation of proteolysis; and negative regulation of trophoblast cell migration. Located in extracellular space. Biomarker of several diseases, including CAKUT2; Down syndrome; artery disease (multiple); carcinoma (multiple); and diabetes mellitus (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: CLGI; collagenase inhibitor; EPA; EPO; erythroid potentiating activity; erythroid-potentiating activity; fibroblast collagenase inhibitor; FLJ90373; HCI; metalloproteinase inhibitor 1; TIMP; TIMP-1; tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor); tissue inhibitor of metalloproteinases 1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X47,582,436 - 47,586,789 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX47,582,408 - 47,586,789 (+)EnsemblGRCh38hg38GRCh38
GRCh37X47,441,835 - 47,446,188 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X47,326,634 - 47,331,134 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X47,198,084 - 47,202,441NCBI
CeleraX51,636,947 - 51,641,447 (+)NCBICelera
Cytogenetic MapXp11.3NCBI
HuRefX45,154,211 - 45,158,632 (+)NCBIHuRef
CHM1_1X47,472,792 - 47,477,292 (+)NCBICHM1_1
T2T-CHM13v2.0X46,992,326 - 46,996,679 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


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TIMP1Humanadrenoleukodystrophy severityIEP 13204814protein:increased expression:cerebrospinal fluidRGD 
TIMP1Humanatherosclerosis amelioratesISOTimp1 (Mus musculus)242905202 RGD 
TIMP1HumanBrain Injuries  ISOTimp1 (Rattus norvegicus)2290468mRNA:increased expression:brain and astrocytesRGD 
TIMP1Humanbreast cancer disease_progressionIEP 2290343protein:increased expression:serumRGD 
TIMP1Humanbreast cancer disease_progressionIEP 2290345mRNA and protein:increased expression:breastRGD 
TIMP1Humanbreast cancer disease_progressionIEP 2290348mRNA and protein:increased expression:breastRGD 
TIMP1HumanCAKUT2 treatmentIEP 13204792 RGD 
TIMP1Humancholestasis  ISOTimp1 (Rattus norvegicus)2290364 RGD 
TIMP1Humanchronic obstructive pulmonary disease treatmentISOTimp1 (Rattus norvegicus)13207319 RGD 
TIMP1Humancongestive heart failure  ISOTimp1 (Rattus norvegicus)2290467protein:increased expression:heart left ventricleRGD 
TIMP1HumanCOVID-19  HEP 28912744mRNA:increased expression:peripheral blood mononuclear cell (human)RGD 
TIMP1Humancystic fibrosis  IEP 13204794protein:increased expression:serumRGD 
TIMP1Humandegenerative disc disease treatmentISOTimp1 (Rattus norvegicus)10043178associated with Renal InsufficiencyRGD 
TIMP1Humandiabetes mellitus  IEP 2312464protein:decreased expression:glomerulusRGD 
TIMP1HumanDown syndrome  IEP 13204810 RGD 
TIMP1HumanEmphysema treatmentISOTimp1 (Rattus norvegicus)13207325 RGD 
TIMP1Humanendometrial carcinoma disease_progressionIEP 2298523protein:increased expression:endometriumRGD 
TIMP1HumanExperimental Diabetes Mellitus  IMP 2312467 RGD 
TIMP1HumanExperimental Diabetes Mellitus  ISOTimp1 (Rattus norvegicus)2290354protein:increased expression:kidneyRGD 
TIMP1HumanExperimental Liver Cirrhosis  ISOTimp1 (Rattus norvegicus)2290364mRNA:increased expression:liverRGD 
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TIMP1Humanautistic disorder  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: AutismClinVarPMID:21681106 and PMID:30208311
TIMP1Humancongenital disorder of glycosylation type IIm  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: DEVELOPMENTAL AND EPILEPTIC ENCEPHALOPATHY 22ClinVarPMID:28492532
TIMP1Humanimmune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Insulin-dependent diabetes mellitus secretory diarrhea syndromeClinVarPMID:11137992 more ...
TIMP1Humanneurodegeneration with brain iron accumulation 5  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Beta-propeller protein-associated neurodegenerationClinVarPMID:28492532
TIMP1Humansyndromic X-linked intellectual disability Lubs type  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Syndromic X-linked intellectual disability Lubs typeClinVarPMID:25741868
TIMP1HumanX-linked epilepsy with variable learning disabilities and behavior disorders  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Epilepsy more ...ClinVarPMID:14985377 more ...
TIMP1HumanX-linked epilepsy with variable learning disabilities and behavior disorders  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Epilepsy more ...ClinVarPMID:25741868 and PMID:28492532
TIMP1HumanX-linked epilepsy with variable learning disabilities and behavior disorders  IAGP (Homo sapiens) more ...8554872ClinVar more ...ClinVarPMID:28492532
TIMP1HumanX-linked severe congenital neutropenia  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: X-linked severe congenital neutropeniaClinVarPMID:10698340 more ...
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TIMP1Humanadult respiratory distress syndrome  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:25070658
TIMP1Humanalcoholic liver cirrhosis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:23274713
TIMP1HumanAnimal Disease Models  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:21051829
TIMP1Humanaortic valve insufficiency  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:21216836
TIMP1Humanautoimmune disease  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:25055964
TIMP1Humancalcinosis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:21335463
TIMP1Humancholangitis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:25055964
TIMP1HumanExperimental Diabetes Mellitus  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:21963884
TIMP1HumanExperimental Liver Cirrhosis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:16507762 more ...
TIMP1Humanextrahepatic cholestasis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:28789951
TIMP1HumanFemale Urogenital Diseases  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:16002989
TIMP1Humanheart disease  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:23558518
TIMP1Humanheart valve disease  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:21335463
TIMP1Humanhypertension  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:21051829
TIMP1HumanIgA glomerulonephritis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:25133636
TIMP1HumanInflammation  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:17569694
TIMP1HumanNeoplasm Invasiveness  EXP 11554173CTD Direct Evidence: therapeuticCTDPMID:1318976
TIMP1Humanoral submucous fibrosis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:16311067
TIMP1Humanpulmonary fibrosis  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:21468558
TIMP1Humantype 2 diabetes mellitus  EXP 11554173CTD Direct Evidence: marker/mechanismCTDPMID:16023759
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TIMP1Human(-)-demecolcine increases expressionEXP 6480464Demecolcine results in increased expression of TIMP1 mRNACTDPMID:23649840
TIMP1Human(-)-epigallocatechin 3-gallate multiple interactionsISOTimp1 (Mus musculus)6480464epigallocatechin gallate inhibits the reaction [Carbon Tetrachloride results in increased expression of TIMP1 mRNA]CTDPMID:20438794
TIMP1Human(1->4)-beta-D-glucan multiple interactionsISOTimp1 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of TIMP1 mRNACTDPMID:36331819
TIMP1Human(2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]-1-oxopentyl]-4-methyl-2-piperidinecarboxylic acid multiple interactionsISOTimp1 (Mus musculus)6480464argatroban inhibits the reaction [Dietary Fats results in increased expression of TIMP1 mRNA]CTDPMID:22841818
TIMP1Human(R)-carnitine multiple interactionsISOTimp1 (Rattus norvegicus)6480464Carnitine inhibits the reaction [sunitinib results in increased expression of TIMP1 mRNA]CTDPMID:26581635
TIMP1Human(S)-colchicine increases expressionISOTimp1 (Rattus norvegicus)6480464Colchicine results in increased expression of TIMP1 mRNACTDPMID:20624997
TIMP1Human(S)-nicotine multiple interactionsEXP 6480464[Nicotine co-treated with lipopolysaccharide and E. coli O26-B6] affects the expression of TIMP1 mRNACTDPMID:18986645
TIMP1Human(S)-nicotine increases expressionISOTimp1 (Rattus norvegicus)6480464Nicotine results in increased expression of TIMP1 mRNACTDPMID:34153408
TIMP1Human(S)-nicotine affects expressionEXP 6480464Nicotine affects the expression of TIMP1 mRNACTDPMID:18986645
TIMP1Human1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane decreases expressionEXP 6480464o and p'-DDT results in decreased expression of TIMP1 mRNACTDPMID:26225806
TIMP1Human1,1-dichloroethene increases expressionISOTimp1 (Mus musculus)6480464vinylidene chloride results in increased expression of TIMP1 mRNACTDPMID:26682919
TIMP1Human1,2,4-trimethylbenzene increases expressionISOTimp1 (Rattus norvegicus)6480464pseudocumene results in increased expression of TIMP1 proteinCTDPMID:17337753
TIMP1Human1,2-dimethylhydrazine increases expressionISOTimp1 (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of TIMP1 mRNACTDPMID:22206623
TIMP1Human1,3,5-trinitro-1,3,5-triazinane increases expressionISOTimp1 (Rattus norvegicus)6480464cyclonite results in increased expression of TIMP1 mRNACTDPMID:25559034
TIMP1Human1-chloro-2,4-dinitrobenzene affects expressionISOTimp1 (Mus musculus)6480464Dinitrochlorobenzene affects the expression of TIMP1 mRNACTDPMID:22302311
TIMP1Human1-naphthyl isothiocyanate increases expressionISOTimp1 (Rattus norvegicus)64804641-Naphthylisothiocyanate results in increased expression of TIMP1 mRNACTDPMID:17522070 more ...
TIMP1Human1-naphthyl isothiocyanate multiple interactionsISOTimp1 (Mus musculus)6480464F2R protein promotes the reaction [1-Naphthylisothiocyanate results in increased expression of TIMP1 mRNA] more ...CTDPMID:21037076 and PMID:24633426
TIMP1Human1-naphthyl isothiocyanate increases expressionISOTimp1 (Mus musculus)64804641-Naphthylisothiocyanate results in increased expression of TIMP1 mRNA and 1-Naphthylisothiocyanate results in increased expression of TIMP1 proteinCTDPMID:21037076 more ...
TIMP1Human1-octadec-9-enoylglycero-3-phosphate multiple interactionsISOTimp1 (Mus musculus)64804643-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid inhibits the reaction [lysophosphatidic acid results in increased expression of TIMP1 protein]CTDPMID:25822713
TIMP1Human1-octadec-9-enoylglycero-3-phosphate increases expressionISOTimp1 (Mus musculus)6480464lysophosphatidic acid results in increased expression of TIMP1 proteinCTDPMID:25822713

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Biological Process
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TIMP1Humancartilage development  ISOTimp1 (Rattus norvegicus)9068941 RGDPMID:16208432 and REF_RGD_ID:8694091
TIMP1Humancartilage development involved_inIEAUniProtKB:P30120 and ensembl:ENSRNOP00000013745150520179 EnsemblGO_REF:0000107
TIMP1Humancellular response to peptide  ISOTimp1 (Rattus norvegicus)9068941 RGDPMID:17555880 and REF_RGD_ID:2290355
TIMP1Humancellular response to peptide involved_inIEAUniProtKB:P30120 and ensembl:ENSRNOP00000013745150520179 EnsemblGO_REF:0000107
TIMP1Humancellular response to UV-A involved_inIDA 150520179 PMID:31380578UniProtPMID:31380578
TIMP1Humanconnective tissue replacement involved in inflammatory response wound healing acts_upstream_of_or_withinIEAUniProtKB:P12032 and ensembl:ENSMUSP00000110999150520179 EnsemblGO_REF:0000107
TIMP1Humannegative regulation of apoptotic process  ISOTimp1 (Rattus norvegicus)9068941 RGDPMID:12081564 and REF_RGD_ID:1580121
TIMP1Humannegative regulation of apoptotic process involved_inIEAUniProtKB:P30120 and ensembl:ENSRNOP00000013745150520179 EnsemblGO_REF:0000107
TIMP1Humannegative regulation of catalytic activity involved_inIDA 150520179 PMID:3903517UniProtPMID:3903517
TIMP1Humannegative regulation of endopeptidase activity involved_inIDA 150520179 PMID:3903517UniProtPMID:3903517
TIMP1Humannegative regulation of membrane protein ectodomain proteolysis involved_inIDA 150520179 PMID:12714508UniProtPMID:12714508
TIMP1Humannegative regulation of membrane protein ectodomain proteolysis involved_inIBAPANTHER:PTN000931945 more ...150520179 GO_CentralGO_REF:0000033
TIMP1Humannegative regulation of metallopeptidase activity involved_inIDA 150520179 PMID:9573338UniProtPMID:9573338
TIMP1Humannegative regulation of trophoblast cell migration involved_inIMP 150520179 PMID:21356369BHF-UCLPMID:21356369
TIMP1Humanpositive regulation of cell population proliferation involved_inIDA 150520179 PMID:3839290UniProtPMID:3839290
TIMP1Humanregulation of integrin-mediated signaling pathway involved_inIMP 150520179 PMID:16917503UniProtPMID:16917503
TIMP1Humanresponse to cytokine  ISOTimp1 (Rattus norvegicus)9068941 RGDPMID:10435007 and REF_RGD_ID:2290469
TIMP1Humanresponse to cytokine involved_inIBAPANTHER:PTN002625923 more ...150520179 GO_CentralGO_REF:0000033
TIMP1Humanresponse to cytokine involved_inIEAUniProtKB:P30120 and ensembl:ENSRNOP00000013745150520179 EnsemblGO_REF:0000107
TIMP1Humanresponse to hormone involved_inIBAPANTHER:PTN002625923 and Timp1 (Rattus norvegicus)150520179 GO_CentralGO_REF:0000033
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Cellular Component
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TIMP1Humanbasement membrane  ISOTimp1 (Rattus norvegicus)9068941 RGDPMID:9579471 and REF_RGD_ID:2290365
TIMP1Humanbasement membrane located_inIEAUniProtKB:P12032 more ...150520179 EnsemblGO_REF:0000107
TIMP1Humancollagen trimer part_ofIEAUniProtKB-KW:KW-0176150520179 UniProtGO_REF:0000043
TIMP1Humanendoplasmic reticulum lumen located_inTAS 150520179 ReactomeReactome:R-HSA-8952289
TIMP1Humanextracellular exosome located_inHDA 150520179 PMID:23533145UniProtPMID:23533145
TIMP1Humanextracellular matrix located_inIEAUniProtKB:P12032 and ensembl:ENSMUSP00000110999150520179 EnsemblGO_REF:0000107
TIMP1Humanextracellular matrix is_active_inIBAMGI:98752 more ...150520179 GO_CentralGO_REF:0000033
TIMP1Humanextracellular region located_inIEAUniProtKB-SubCell:SL-0243150520179 UniProtGO_REF:0000044
TIMP1Humanextracellular region located_inNAS 150520179 PMID:1653055UniProtPMID:1653055
TIMP1Humanextracellular region located_inIEAUniProtKB-KW:KW-0964150520179 UniProtGO_REF:0000043
TIMP1Humanextracellular region located_inTAS 150520179 ReactomeReactome:R-HSA-1602454 more ...
TIMP1Humanextracellular space located_inIDA 150520179 PMID:3903517UniProtPMID:3903517
TIMP1Humanextracellular space is_active_inIBAPANTHER:PTN000931945 more ...150520179 GO_CentralGO_REF:0000033
TIMP1Humanplatelet alpha granule lumen located_inTAS 150520179 ReactomeReactome:R-HSA-481007
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Molecular Function
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TIMP1Humancytokine activity enablesIDA 150520179 PMID:3839290UniProtPMID:3839290
TIMP1Humanenzyme inhibitor activity enablesIEAUniProtKB-KW:KW-0481150520179 UniProtGO_REF:0000043
TIMP1Humangrowth factor activity enablesIEAUniProtKB-KW:KW-0339150520179 UniProtGO_REF:0000043
TIMP1Humanmetal ion binding enablesIEAUniProtKB-KW:KW-0479150520179 UniProtGO_REF:0000043
TIMP1Humanmetalloendopeptidase inhibitor activity enablesIDA 150520179 PMID:12714508 and PMID:3903517UniProtPMID:12714508 and PMID:3903517
TIMP1Humanmetalloendopeptidase inhibitor activity enablesIBAFB:FBgn0025879 more ...150520179 GO_CentralGO_REF:0000033
TIMP1Humanmetalloendopeptidase inhibitor activity enablesIEAInterPro:IPR001820150520179 InterProGO_REF:0000002
TIMP1Humanpeptidase inhibitor activity enablesIDA 150520179 PMID:9573338UniProtPMID:9573338
TIMP1Humanpeptidase inhibitor activity enablesIEAUniProtKB-KW:KW-0483 and UniProtKB-KW:KW-0646150520179 UniProtGO_REF:0000043
TIMP1Humanprotease binding  ISOMmp1 (Rattus norvegicus)9068941 RGDPMID:21846328 and REF_RGD_ID:7207284
TIMP1Humanprotease binding enablesIEAUniProtKB:P30120 and ensembl:ENSRNOP00000013745150520179 EnsemblGO_REF:0000107
TIMP1Humanprotein binding enablesIPIUniProtKB:P08962150520179 PMID:16917503IntActPMID:16917503
TIMP1Humanprotein binding enablesIPIUniProtKB:P14780150520179 PMID:2251898UniProtPMID:2251898
TIMP1Humanprotein binding enablesIPIUniProtKB:P08962 and UniProtKB:P27701150520179 PMID:28030805IntActPMID:28030805
TIMP1Humanprotein binding enablesIPIUniProtKB:P20908150520179 PMID:20979576IntActPMID:20979576
TIMP1Humanzinc ion binding enablesIDA 150520179 PMID:22427646UniProtPMID:22427646
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Imported Annotations - PID (archival)

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TIMP1Humaninterleukin-6 signaling pathway   EXP 6484113 PIDPID:200146
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TIMP1HumanAutism  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: AutismClinVarPMID:21681106 and PMID:30208311

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Reference Title
Reference Citation
1. Role of TIMP-1 and TIMP-2 in the progression of cerebral aneurysms. Aoki T, etal., Stroke. 2007 Aug;38(8):2337-45. Epub 2007 Jun 14.
2. Serum MMP-9/TIMP-1 and MMP-2/TIMP-2 ratios in multiple sclerosis: relationships with different magnetic resonance imaging measures of disease activity during IFN-beta-1a treatment. Avolio C, etal., Mult Scler. 2005 Aug;11(4):441-6.
3. Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase (TIMP-1) in patients with relapsing-remitting multiple sclerosis treated with interferon beta. Boz C, etal., Clin Neurol Neurosurg. 2006 Feb;108(2):124-8.
4. Spatial and temporal pattern of expression of interstitial collagenase, stromelysin/transin, gelatinase A, and TIMP-1 during experimental gastric ulcer healing. Calabro A, etal., Digestion. 2004;70(2):127-38. Epub 2004 Sep 16.
5. Elevated levels of matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 during the acute phase of Kawasaki disease. Chua PK, etal., Clin Diagn Lab Immunol. 2003 Mar;10(2):308-14.
6. Glomerular Protein Levels of Matrix Metalloproteinase-1 and Tissue Inhibitor of Metalloproteinase-1 Are Lower in Diabetic Subjects. Cornish TC, etal., J Histochem Cytochem. 2009 Jun 8.
7. Investigation of the molecular mechanisms preceding PDE4 inhibitor-induced vasculopathy in rats: tissue inhibitor of metalloproteinase 1, a potential predictive biomarker. Dagues N, etal., Toxicol Sci. 2007 Nov;100(1):238-47. Epub 2007 Jun 14.
8. Differential spatial distribution and temporal regulation of tissue inhibitor of metalloproteinase mRNA expression during rat central nervous system development. Fager N and Jaworski DM, Mech Dev. 2000 Nov;98(1-2):105-9.
9. [Metalloproteinases MMP-2 and MMP-9 and their inhibitors TIMP-1 and TIMP-2 levels in children and adolescents with type 1 diabetes.] Florys B, etal., Endokrynol Diabetol Chor Przemiany Materii Wieku Rozw. 2006;12(3):184-9.
10. Elevated matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 in obese children and adolescents. Glowinska-Olszewska B and Urban M, Metabolism. 2007 Jun;56(6):799-805.
11. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
12. Tissue inhibitor of metalloproteinase 1 is an independent predictor of prognosis in patients with nonsmall cell lung carcinoma who undergo resection with curative intent. Gouyer V, etal., Cancer. 2005 Apr 15;103(8):1676-84.
13. [Expression of matrix metalloproteinase-2, 9 and it's tissue inhibitor-1, 2 in endometrial carcinoma] Guo W, etal., Zhonghua Fu Chan Ke Za Zhi. 2002 Oct;37(10):604-7.
14. Increased cardiac expression of tissue inhibitor of metalloproteinase-1 and tissue inhibitor of metalloproteinase-2 is related to cardiac fibrosis and dysfunction in the chronic pressure-overloaded human heart. Heymans S, etal., Circulation. 2005 Aug 23;112(8):1136-44. Epub 2005 Aug 15.
15. Hyperoxia decreases matrix metalloproteinase-9 and increases tissue inhibitor of matrix metalloproteinase-1 protein in the newborn rat lung: association with arrested alveolarization. Hosford GE, etal., Pediatr Res. 2004 Jul;56(1):26-34. Epub 2004 May 5.
16. Upregulation of tissue inhibitor of metalloproteases-1 (TIMP-1) and procollagen-N-peptidase in hypertension-induced renal damage. Hultstrom M, etal., Nephrol Dial Transplant. 2008 Mar;23(3):896-903. Epub 2007 Oct 31.
17. Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with Marfan syndrome. Ikonomidis JS, etal., Circulation. 2006 Jul 4;114(1 Suppl):I365-70.
18. Tissue inhibitor of metalloproteinase-1 messenger RNA expression is enhanced relative to interstitial collagenase messenger RNA in experimental liver injury and fibrosis. Iredale JP, etal., Hepatology. 1996 Jul;24(1):176-84.
19. Nerve growth factor metabolic dysfunction in Down's syndrome brains. Iulita MF, etal., Brain. 2014 Mar;137(Pt 3):860-72. doi: 10.1093/brain/awt372. Epub 2014 Feb 11.
20. Differential regulation of tissue inhibitor of metalloproteinase mRNA expression in response to intracranial injury. Jaworski DM Glia. 2000 Apr;30(2):199-208.
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PMID:1420137   PMID:1653055   PMID:1730286   PMID:2163605   PMID:2171551   PMID:2251898   PMID:2921031   PMID:3010309   PMID:3460333   PMID:3688834   PMID:3839290   PMID:3903517  
PMID:7507419   PMID:8757599   PMID:8804434   PMID:9063449   PMID:9286280   PMID:9288970   PMID:9573338   PMID:9778693   PMID:10071915   PMID:10233411   PMID:10441576   PMID:10623524  
PMID:10895974   PMID:11279011   PMID:11598182   PMID:11606052   PMID:11705862   PMID:11762702   PMID:11796725   PMID:11935340   PMID:11940298   PMID:12032189   PMID:12034345   PMID:12063180  
PMID:12082592   PMID:12147251   PMID:12150976   PMID:12376362   PMID:12406369   PMID:12452001   PMID:12475252   PMID:12477932   PMID:12479097   PMID:12496489   PMID:12538453   PMID:12612199  
PMID:12620441   PMID:12634064   PMID:12651627   PMID:12704667   PMID:12714508   PMID:12717827   PMID:12771930   PMID:12791318   PMID:12834347   PMID:12846741   PMID:12861139   PMID:12869573  
PMID:12873541   PMID:12904305   PMID:12921631   PMID:12970724   PMID:14517716   PMID:14622947   PMID:14630798   PMID:14648584   PMID:14652000   PMID:14661256   PMID:14688084   PMID:14710472  
PMID:14734567   PMID:14871825   PMID:14962256   PMID:14973177   PMID:14983226   PMID:15028476   PMID:15051730   PMID:15161657   PMID:15248826   PMID:15277439   PMID:15313474   PMID:15340161  
PMID:15363817   PMID:15465038   PMID:15479729   PMID:15485866   PMID:15489334   PMID:15494493   PMID:15515157   PMID:15516987   PMID:15530852   PMID:15557756   PMID:15754388   PMID:15818737  
PMID:15841325   PMID:15890357   PMID:15896974   PMID:16019435   PMID:16061701   PMID:16100012   PMID:16107690   PMID:16135528   PMID:16169070   PMID:16188099   PMID:16191301   PMID:16219294  
PMID:16248458   PMID:16263699   PMID:16280123   PMID:16288711   PMID:16289162   PMID:16303743   PMID:16335952   PMID:16407831   PMID:16410344   PMID:16474379   PMID:16496359   PMID:16555295  
1 to 10 of 62 rows



TIMP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X47,582,436 - 47,586,789 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX47,582,408 - 47,586,789 (+)EnsemblGRCh38hg38GRCh38
GRCh37X47,441,835 - 47,446,188 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X47,326,634 - 47,331,134 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X47,198,084 - 47,202,441NCBI
CeleraX51,636,947 - 51,641,447 (+)NCBICelera
Cytogenetic MapXp11.3NCBI
HuRefX45,154,211 - 45,158,632 (+)NCBIHuRef
CHM1_1X47,472,792 - 47,477,292 (+)NCBICHM1_1
T2T-CHM13v2.0X46,992,326 - 46,996,679 (+)NCBIT2T-CHM13v2.0
Timp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X20,736,524 - 20,740,972 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX20,736,405 - 20,740,974 (+)EnsemblGRCm39 Ensembl
GRCm38X20,870,166 - 20,874,737 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX20,870,166 - 20,874,735 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X20,447,292 - 20,451,863 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X20,027,998 - 20,031,591 (+)NCBIMGSCv36mm8
CeleraX19,001,307 - 19,005,878 (+)NCBICelera
Cytogenetic MapXA1.3NCBI
cM MapX16.38NCBI
Timp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X3,766,509 - 3,772,578 (-)NCBIGRCr8
mRatBN7.2X1,212,969 - 1,217,714 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX1,212,972 - 1,217,664 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX1,241,133 - 1,245,729 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X4,716,824 - 4,721,420 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X1,037,983 - 1,042,580 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X1,364,771 - 1,369,451 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX1,364,786 - 1,369,384 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X2,179,962 - 2,184,814 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X12,542,496 - 12,547,094 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X12,548,051 - 12,552,650 (-)NCBI
CeleraX1,780,586 - 1,785,184 (-)NCBICelera
Cytogenetic MapXq11NCBI
Timp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955516505,789 - 512,118 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955516507,113 - 511,360 (-)NCBIChiLan1.0ChiLan1.0
TIMP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X49,208,573 - 49,213,215 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X49,212,076 - 49,216,587 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X40,018,190 - 40,022,636 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X47,914,906 - 47,919,419 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX47,914,906 - 47,919,419 (+)Ensemblpanpan1.1panPan2
TIMP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X41,201,623 - 41,205,314 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX41,201,638 - 41,205,310 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX15,576,764 - 15,580,333 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X41,335,929 - 41,339,499 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX41,335,826 - 41,339,498 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X41,323,532 - 41,327,103 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X41,311,800 - 41,315,371 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X41,404,449 - 41,408,018 (+)NCBIUU_Cfam_GSD_1.0
Timp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X33,505,193 - 33,509,420 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650213,345,832 - 13,350,248 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650213,345,936 - 13,350,170 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TIMP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX42,102,172 - 42,106,296 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X42,103,251 - 42,106,289 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X47,372,604 - 47,375,643 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig CytomapXpNCBI
TIMP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366607610,014,573 - 10,051,570 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Timp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624978121,803 - 124,912 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624978120,723 - 125,006 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in TIMP1
13 total Variants

1 to 10 of 197 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
GRCh38/hg38 Xp22.33-q28(chrX:3092486-155699618)x2 copy number gain See cases [RCV000050889] ChrX:3092486..155699618 [GRCh38]
ChrX:3010527..154929279 [GRCh37]
ChrX:3020527..154582473 [NCBI36]
ChrX:Xp22.33-q28		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:20140-155699618)x3 copy number gain See cases [RCV000050810] ChrX:20140..155699618 [GRCh38]
ChrX:70140..154929279 [GRCh37]
ChrX:10140..154582473 [NCBI36]
ChrX:Xp22.33-q28		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:20140-155699618)x1 copy number loss See cases [RCV000050811] ChrX:20140..155699618 [GRCh38]
ChrX:70140..154929279 [GRCh37]
ChrX:10140..154582473 [NCBI36]
ChrX:Xp22.33-q28		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:10679-156022206)x1 copy number loss See cases [RCV000050699] ChrX:10679..156022206 [GRCh38]
ChrX:60679..155251871 [GRCh37]
ChrX:679..154905065 [NCBI36]
ChrX:Xp22.33-q28		 pathogenic|conflicting interpretations of pathogenicity|conflicting data from submitters
GRCh38/hg38 Xp22.33-q28(chrX:10679-156013167)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000050385]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000050385]|See cases [RCV000050385] ChrX:10679..156013167 [GRCh38]
ChrX:60679..155242832 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:10679-156013167)x1 copy number loss Global developmental delay [RCV000050386]|See cases [RCV000050386] ChrX:10679..156013167 [GRCh38]
ChrX:60679..155242832 [GRCh37]
ChrX:Xp22.33-q28		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:10679-156022206)x3 copy number gain See cases [RCV000050697] ChrX:10679..156022206 [GRCh38]
ChrX:60679..155251871 [GRCh37]
ChrX:679..154905065 [NCBI36]
ChrX:Xp22.33-q28		 pathogenic|conflicting interpretations of pathogenicity|conflicting data from submitters
GRCh38/hg38 Xp22.33-11.22(chrX:10679-52809182)x1 copy number loss See cases [RCV000051026] ChrX:10679..52809182 [GRCh38]
ChrX:60679..52838206 [GRCh37]
ChrX:679..52854931 [NCBI36]
ChrX:Xp22.33-11.22		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:26101-155999293)x3 copy number gain See cases [RCV000052322] ChrX:26101..155999293 [GRCh38]
ChrX:76101..155228958 [GRCh37]
ChrX:16101..154882152 [NCBI36]
ChrX:Xp22.33-q28		 pathogenic
GRCh38/hg38 Xp22.33-q28(chrX:2790845-155699618)x3 copy number gain See cases [RCV000052359] ChrX:2790845..155699618 [GRCh38]
ChrX:2708886..154929279 [GRCh37]
ChrX:2718886..154582473 [NCBI36]
ChrX:Xp22.33-q28		 pathogenic
1 to 10 of 197 rows

Predicted Target Of
Summary Value
Count of predictions:2046
Count of miRNA genes:821
Interacting mature miRNAs:915
Transcripts:ENST00000218388, ENST00000377017, ENST00000377018, ENST00000441738, ENST00000445623, ENST00000456754
Prediction methods:Microtar, Miranda, Pita, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

STS-AA001911  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37X47,445,999 - 47,446,181UniSTSGRCh37
Build 36X47,330,943 - 47,331,125RGDNCBI36
CeleraX51,641,256 - 51,641,438RGD
Cytogenetic MapXp11.23UniSTS
Cytogenetic MapXp11.3-p11.23UniSTS
HuRefX45,158,441 - 45,158,623UniSTS
GeneMap99-GB4 RH MapX135.36UniSTS
GDB:192509  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37X47,446,080 - 47,446,186UniSTSGRCh37
Build 36X47,331,024 - 47,331,130RGDNCBI36
CeleraX51,641,337 - 51,641,443RGD
Cytogenetic MapXp11.23UniSTS
Cytogenetic MapXp11.3-p11.23UniSTS
HuRefX45,158,522 - 45,158,628UniSTS
GDB:178392  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37X47,442,834 - 47,446,098UniSTSGRCh37
Build 36X47,327,778 - 47,331,042RGDNCBI36
CeleraX51,638,091 - 51,641,355RGD
Cytogenetic MapXp11.3-p11.23UniSTS
HuRefX45,155,276 - 45,158,540UniSTS
GDB:182149  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37X47,442,915 - 47,446,098UniSTSGRCh37
Build 36X47,327,859 - 47,331,042RGDNCBI36
CeleraX51,638,172 - 51,641,355RGD
Cytogenetic MapXp11.3-p11.23UniSTS
HuRefX45,155,357 - 45,158,540UniSTS
GDB:182150  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37X47,444,346 - 47,446,098UniSTSGRCh37
Build 36X47,329,290 - 47,331,042RGDNCBI36
CeleraX51,639,603 - 51,641,355RGD
Cytogenetic MapXp11.3-p11.23UniSTS
HuRefX45,156,788 - 45,158,540UniSTS




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2439 2788 2251 4968 1726 2347 5 624 1942 465 2270 7297 6463 53 3728 1 851 1743 1614 174 1


1 to 30 of 33 rows
RefSeq Transcripts NG_008437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NG_012533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_003254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017029766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide A10416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK074854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK296116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK307222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK310206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK311937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY932824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC000866 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC007097 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ181804 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU857950 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR407638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR541982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D11139 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FB571112 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FB668243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GQ891504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HI574166 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L47357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L47361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M12670 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M59906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S68252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X02598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 30 of 33 rows

Ensembl Acc Id: ENST00000218388   ⟹   ENSP00000218388
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 EnsemblX47,582,436 - 47,586,789 (+)Ensembl
Ensembl Acc Id: ENST00000377017   ⟹   ENSP00000366216
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 EnsemblX47,582,450 - 47,586,789 (+)Ensembl
Ensembl Acc Id: ENST00000441738   ⟹   ENSP00000405380
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 EnsemblX47,582,509 - 47,585,254 (+)Ensembl
Ensembl Acc Id: ENST00000445623   ⟹   ENSP00000410983
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 EnsemblX47,585,342 - 47,586,789 (+)Ensembl
Ensembl Acc Id: ENST00000456754   ⟹   ENSP00000406671
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 EnsemblX47,582,408 - 47,586,023 (+)Ensembl
RefSeq Acc Id: NM_003254   ⟹   NP_003245
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38X47,582,436 - 47,586,789 (+)NCBI
GRCh37X47,441,690 - 47,446,190 (+)ENTREZGENE
Build 36X47,326,634 - 47,331,134 (+)NCBI Archive
HuRefX45,154,211 - 45,158,632 (+)ENTREZGENE
CHM1_1X47,472,792 - 47,477,292 (+)NCBI
T2T-CHM13v2.0X46,992,326 - 46,996,679 (+)NCBI
Sequence:
RefSeq Acc Id: NP_003245   ⟸   NM_003254
- Peptide Label: precursor
- UniProtKB: Q14252 (UniProtKB/Swiss-Prot),   Q9UCU1 (UniProtKB/Swiss-Prot),   P01033 (UniProtKB/Swiss-Prot),   Q6FGX5 (UniProtKB/TrEMBL),   B3KQF4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSP00000218388   ⟸   ENST00000218388
Ensembl Acc Id: ENSP00000405380   ⟸   ENST00000441738
Ensembl Acc Id: ENSP00000366216   ⟸   ENST00000377017
Ensembl Acc Id: ENSP00000406671   ⟸   ENST00000456754
NTR

Name Modeler Protein Id AA Range Protein Structure
AF-P01033-F1-model_v2 AlphaFold P01033 1-207 view protein structure

RGD ID:6808701
Promoter ID:HG_KWN:66616
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000377013,   ENST00000377017,   NM_003254,   OTTHUMT00000056426,   UC010NHT.1
Position:
Human AssemblyChrPosition (strand)Source
Build 36X47,326,466 - 47,326,966 (+)MPROMDB
RGD ID:6853158
Promoter ID:EP74400
Type:multiple initiation site
Name:HS_TIMP1
Description:Tissue inhibitor of metalloproteinase 1 (erythroid potentiatingactivity, collagenase inhibitor).
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Mammalian gene collection (MGC) full-length cDNA cloning
Position:
Human AssemblyChrPosition (strand)Source
Build 36X47,326,779 - 47,326,839EPD
RGD ID:6809327
Promoter ID:HG_KWN:66617
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562,   Lymphoblastoid
Transcripts:OTTHUMT00000056427
Position:
Human AssemblyChrPosition (strand)Source
Build 36X47,329,126 - 47,329,732 (+)MPROMDB
RGD ID:13605176
Promoter ID:EPDNEW_H28772
Type:initiation region
Name:TIMP1_2
Description:TIMP metallopeptidase inhibitor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H28773  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38X47,582,305 - 47,582,365EPDNEW
RGD ID:13605178
Promoter ID:EPDNEW_H28773
Type:initiation region
Name:TIMP1_1
Description:TIMP metallopeptidase inhibitor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H28772  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38X47,582,439 - 47,582,499EPDNEW


1 to 38 of 38 rows
Database
Acc Id
Source(s)
COSMIC TIMP1 COSMIC
Ensembl Genes ENSG00000102265 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000218388 ENTREZGENE
  ENST00000218388.9 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.50.120 UniProtKB/Swiss-Prot
  3.90.370.10 UniProtKB/Swiss-Prot
GTEx ENSG00000102265 GTEx
HGNC ID HGNC:11820 ENTREZGENE
Human Proteome Map TIMP1 Human Proteome Map
InterPro Netrin_domain UniProtKB/Swiss-Prot
  TIMP UniProtKB/Swiss-Prot
  TIMP-like_OB-fold UniProtKB/Swiss-Prot
  TIMP_C UniProtKB/Swiss-Prot
  TIMP_CS UniProtKB/Swiss-Prot
KEGG Report hsa:7076 UniProtKB/Swiss-Prot
NCBI Gene 7076 ENTREZGENE
OMIM 305370 OMIM
PANTHER PTHR11844 UniProtKB/Swiss-Prot
  PTHR11844:SF20 UniProtKB/Swiss-Prot
Pfam TIMP UniProtKB/Swiss-Prot
PharmGKB PA36526 PharmGKB
PROSITE NTR UniProtKB/Swiss-Prot
  TIMP UniProtKB/Swiss-Prot
SMART NTR UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50242 UniProtKB/Swiss-Prot
UniProt B3KQF4 ENTREZGENE, UniProtKB/TrEMBL
  H0Y789_HUMAN UniProtKB/TrEMBL
  P01033 ENTREZGENE
  Q14252 ENTREZGENE
  Q58P21_HUMAN UniProtKB/TrEMBL
  Q5H9A7_HUMAN UniProtKB/TrEMBL
  Q5H9B4_HUMAN UniProtKB/TrEMBL
  Q5H9B5_HUMAN UniProtKB/TrEMBL
  Q6FGX5 ENTREZGENE, UniProtKB/TrEMBL
  Q9UCU1 ENTREZGENE
  TIMP1_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary Q14252 UniProtKB/Swiss-Prot
  Q9UCU1 UniProtKB/Swiss-Prot
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