Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: TIMP1 (TIMP metallopeptidase inhibitor 1) Homo sapiens
Symbol: TIMP1
Name: TIMP metallopeptidase inhibitor 1
Description: Exhibits cytokine activity; metalloendopeptidase inhibitor activity; and zinc ion binding activity. Involved in several processes, including negative regulation of proteolysis; negative regulation of trophoblast cell migration; and regulation of integrin-mediated signaling pathway. Localizes to the extracellular space. Biomarker of several diseases, including CAKUT2; Down syndrome; artery disease (multiple); carcinoma (multiple); and diabetes mellitus (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CLGI; collagenase inhibitor; EPA; EPO; erythroid potentiating activity; erythroid-potentiating activity; fibroblast collagenase inhibitor; FLJ90373; HCI; metalloproteinase inhibitor 1; TIMP; TIMP-1; tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor); tissue inhibitor of metalloproteinases 1
Mus musculus (house mouse) : Timp1 (tissue inhibitor of metalloproteinase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Timp1 (TIMP metallopeptidase inhibitor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Timp1 (TIMP metallopeptidase inhibitor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TIMP1 (TIMP metallopeptidase inhibitor 1)
Canis lupus familiaris (dog) : TIMP1 (TIMP metallopeptidase inhibitor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Timp1 (TIMP metallopeptidase inhibitor 1)
Sus scrofa (pig) : TIMP1 (TIMP metallopeptidase inhibitor 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X47,582,408 - 47,586,789 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X47,441,690 - 47,446,190 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X47,326,634 - 47,331,134 (+)NCBINCBI36hg18NCBI36
Build 34X47,198,084 - 47,202,441NCBI
CeleraX51,636,947 - 51,641,447 (+)NCBI
Cytogenetic MapXp11.3NCBI
HuRefX45,154,211 - 45,158,632 (+)NCBIHuRef
CHM1_1X47,472,792 - 47,477,292 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on TIMP1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1347215
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.