TIMP1 (TIMP metallopeptidase inhibitor 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: TIMP1 (TIMP metallopeptidase inhibitor 1) Canis lupus familiaris
Analyze
Symbol: TIMP1
Name: TIMP metallopeptidase inhibitor 1
RGD ID: 12124520
Description: ENCODES a protein that exhibits cytokine activity (ortholog); metalloendopeptidase inhibitor activity (ortholog); protease binding (ortholog); INVOLVED IN cartilage development (ortholog); cellular response to UV-A (ortholog); connective tissue replacement involved in inflammatory response wound healing (ortholog); PARTICIPATES IN interleukin-6 signaling pathway; ASSOCIATED WITH adrenoleukodystrophy (ortholog); adult respiratory distress syndrome (ortholog); alcoholic liver cirrhosis (ortholog); FOUND IN basement membrane (ortholog); extracellular space (ortholog); INTERACTS WITH spironolactone
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: metalloproteinase inhibitor 1; TIMP-1; tissue inhibitor of matrix metalloproteinase-1; tissue inhibitor of metalloproteinase 1; tissue inhibitor of metalloproteinases 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X41,201,623 - 41,205,314 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX41,201,638 - 41,205,310 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX15,576,764 - 15,580,333 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X41,335,929 - 41,339,499 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX41,335,826 - 41,339,498 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X41,323,532 - 41,327,103 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X41,311,800 - 41,315,371 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X41,404,449 - 41,408,018 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adrenoleukodystrophy  (ISO)
adult respiratory distress syndrome  (ISO)
alcoholic liver cirrhosis  (ISO)
Animal Disease Models  (ISO)
aortic valve insufficiency  (ISO)
atherosclerosis  (ISO)
autistic disorder  (ISO)
autoimmune disease  (ISO)
Brain Injuries  (ISO)
breast cancer  (ISO)
CAKUT2  (ISO)
calcinosis  (ISO)
cholangitis  (ISO)
cholestasis  (ISO)
chronic obstructive pulmonary disease  (ISO)
congenital disorder of glycosylation type IIm  (ISO)
congestive heart failure  (ISO)
COVID-19  (ISO)
cystic fibrosis  (ISO)
degenerative disc disease  (ISO)
diabetes mellitus  (ISO)
Down syndrome  (ISO)
Emphysema  (ISO)
endometrial carcinoma  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
extrahepatic cholestasis  (ISO)
Female Urogenital Diseases  (ISO)
gastric ulcer  (ISO)
genetic disease  (ISO)
heart disease  (ISO)
heart valve disease  (ISO)
Hemorrhagic Shock  (ISO)
hyperhomocysteinemia  (ISO)
Hyperoxia  (ISO)
hypertension  (ISO)
IgA glomerulonephritis  (ISO)
immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome  (ISO)
Inflammation  (ISO)
intracranial aneurysm  (ISO)
Kawasaki disease  (ISO)
Lymphatic Metastasis  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
neurodegeneration with brain iron accumulation 5  (ISO)
obesity  (ISO)
oral submucous fibrosis  (ISO)
ovarian cancer  (ISO)
pre-eclampsia  (ISO)
preretinal fibrosis  (ISO)
pulmonary fibrosis  (ISO)
relapsing-remitting multiple sclerosis  (ISO)
renal cell carcinoma  (ISO)
Stroke  (ISO)
syndromic X-linked intellectual disability Lubs type  (ISO)
thoracic aortic aneurysm  (ISO)
transitional cell carcinoma  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
varicose veins  (ISO)
vascular disease  (ISO)
Wilson disease  (ISO)
Wounds and Injuries  (ISO)
X-linked epilepsy with variable learning disabilities and behavior disorders  (ISO)
X-linked severe congenital neutropenia  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:1794505   PMID:9931441   PMID:18039671   PMID:18706834   PMID:18717642   PMID:22301074   PMID:22701711   PMID:30032202   PMID:30720210  


Genomics

Comparative Map Data
TIMP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X41,201,623 - 41,205,314 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX41,201,638 - 41,205,310 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX15,576,764 - 15,580,333 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X41,335,929 - 41,339,499 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX41,335,826 - 41,339,498 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X41,323,532 - 41,327,103 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X41,311,800 - 41,315,371 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X41,404,449 - 41,408,018 (+)NCBIUU_Cfam_GSD_1.0
TIMP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X47,582,436 - 47,586,789 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX47,582,408 - 47,586,789 (+)EnsemblGRCh38hg38GRCh38
GRCh37X47,441,835 - 47,446,188 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X47,326,634 - 47,331,134 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X47,198,084 - 47,202,441NCBI
CeleraX51,636,947 - 51,641,447 (+)NCBICelera
Cytogenetic MapXp11.3NCBI
HuRefX45,154,211 - 45,158,632 (+)NCBIHuRef
CHM1_1X47,472,792 - 47,477,292 (+)NCBICHM1_1
T2T-CHM13v2.0X46,992,326 - 46,996,679 (+)NCBIT2T-CHM13v2.0
Timp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X20,736,524 - 20,740,972 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX20,736,405 - 20,740,974 (+)EnsemblGRCm39 Ensembl
GRCm38X20,870,166 - 20,874,737 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX20,870,166 - 20,874,735 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X20,447,292 - 20,451,863 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X20,027,998 - 20,031,591 (+)NCBIMGSCv36mm8
CeleraX19,001,307 - 19,005,878 (+)NCBICelera
Cytogenetic MapXA1.3NCBI
cM MapX16.38NCBI
Timp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X3,766,509 - 3,772,578 (-)NCBIGRCr8
mRatBN7.2X1,212,969 - 1,217,714 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX1,212,972 - 1,217,664 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX1,241,133 - 1,245,729 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X4,716,824 - 4,721,420 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X1,037,983 - 1,042,580 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X1,364,771 - 1,369,451 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX1,364,786 - 1,369,384 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X2,179,962 - 2,184,814 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X12,542,496 - 12,547,094 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X12,548,051 - 12,552,650 (-)NCBI
CeleraX1,780,586 - 1,785,184 (-)NCBICelera
Cytogenetic MapXq11NCBI
Timp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955516505,789 - 512,118 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955516507,113 - 511,360 (-)NCBIChiLan1.0ChiLan1.0
TIMP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X49,208,573 - 49,213,215 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X49,212,076 - 49,216,587 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X40,018,190 - 40,022,636 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X47,914,906 - 47,919,419 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX47,914,906 - 47,919,419 (+)Ensemblpanpan1.1panPan2
Timp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X33,505,193 - 33,509,420 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650213,345,832 - 13,350,248 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650213,345,936 - 13,350,170 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TIMP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX42,102,172 - 42,106,296 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X42,103,251 - 42,106,289 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X47,372,604 - 47,375,643 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig CytomapXpNCBI
LOC103231892
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X44,759,412 - 44,763,243 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX44,760,531 - 44,765,571 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366656624,012 - 27,843 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Timp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624978121,803 - 124,912 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624978120,723 - 125,006 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in TIMP1
38 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 16 6 6 6 10 6
Low 5 6 6 6 6 6 8
Below cutoff

Sequence


RefSeq Acc Id: ENSCAFT00000024055   ⟹   ENSCAFP00000022333
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 EnsemblX41,201,638 - 41,205,310 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000065531   ⟹   ENSCAFP00000050322
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 EnsemblX41,201,638 - 41,204,401 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000070963   ⟹   ENSCAFP00000048895
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 EnsemblX41,201,638 - 41,204,401 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000085889   ⟹   ENSCAFP00000043332
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 EnsemblX41,202,661 - 41,204,401 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000092840   ⟹   ENSCAFP00000062428
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 EnsemblX41,201,638 - 41,204,401 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845054234   ⟹   ENSCAFP00845042606
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 EnsemblX41,335,826 - 41,339,498 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845054250   ⟹   ENSCAFP00845042620
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 EnsemblX41,335,883 - 41,338,051 (+)Ensembl
RefSeq Acc Id: NM_001003182   ⟹   NP_001003182
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1X41,201,741 - 41,205,311 (+)NCBI
Dog10K_Boxer_TashaX15,576,764 - 15,580,333 (+)NCBI
ROS_Cfam_1.0X41,335,929 - 41,339,499 (+)NCBI
UMICH_Zoey_3.1X41,323,532 - 41,327,103 (+)NCBI
UNSW_CanFamBas_1.0X41,311,800 - 41,315,371 (+)NCBI
UU_Cfam_GSD_1.0X41,404,449 - 41,408,018 (+)NCBI
Sequence:
RefSeq Acc Id: NP_001003182   ⟸   NM_001003182
- Peptide Label: precursor
- UniProtKB: Q9TQS5 (UniProtKB/Swiss-Prot),   P81546 (UniProtKB/Swiss-Prot),   A0A8C0T2U6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000048895   ⟸   ENSCAFT00000070963
RefSeq Acc Id: ENSCAFP00000062428   ⟸   ENSCAFT00000092840
RefSeq Acc Id: ENSCAFP00000022333   ⟸   ENSCAFT00000024055
RefSeq Acc Id: ENSCAFP00000050322   ⟸   ENSCAFT00000065531
RefSeq Acc Id: ENSCAFP00000043332   ⟸   ENSCAFT00000085889
RefSeq Acc Id: ENSCAFP00845042620   ⟸   ENSCAFT00845054250
RefSeq Acc Id: ENSCAFP00845042606   ⟸   ENSCAFT00845054234
Protein Domains
NTR


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000015155 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030013018 UniProtKB/TrEMBL
  ENSCAFG00040018378 UniProtKB/TrEMBL
  ENSCAFG00845030572 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000024055.5 UniProtKB/TrEMBL
  ENSCAFT00000065531.2 UniProtKB/TrEMBL
  ENSCAFT00030024073.1 UniProtKB/TrEMBL
  ENSCAFT00030024170.1 UniProtKB/TrEMBL
  ENSCAFT00040033948.1 UniProtKB/TrEMBL
  ENSCAFT00040034012.1 UniProtKB/TrEMBL
  ENSCAFT00845054234 ENTREZGENE
  ENSCAFT00845054234.1 UniProtKB/TrEMBL
  ENSCAFT00845054250.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.120 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.370.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Netrin_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP-like_OB-fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP_CS UniProtKB/TrEMBL
KEGG Report cfa:403816 UniProtKB/Swiss-Prot
NCBI Gene TIMP1 ENTREZGENE
PANTHER PTHR11844 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11844:SF20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TIMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP UniProtKB/TrEMBL
SMART NTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50242 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8C0N3C9_CANLF UniProtKB/TrEMBL
  A0A8C0N8Z9_CANLF UniProtKB/TrEMBL
  A0A8C0T2U6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3Q4H4_CANLF UniProtKB/TrEMBL
  A0A8I3QNP2_CANLF UniProtKB/TrEMBL
  P81546 ENTREZGENE
  Q9TQS5 ENTREZGENE
  TIMP1_CANLF UniProtKB/Swiss-Prot
UniProt Secondary Q9TQS5 UniProtKB/Swiss-Prot
VGNC ID VGNC:47376 ENTREZGENE