Timp1 (TIMP metallopeptidase inhibitor 1) - Rat Genome Database

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Gene: Timp1 (TIMP metallopeptidase inhibitor 1) Ictidomys tridecemlineatus
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Symbol: Timp1
Name: TIMP metallopeptidase inhibitor 1
RGD ID: 12551412
Description: ENCODES a protein that exhibits protease binding (ortholog); INVOLVED IN aging (ortholog); cartilage development (ortholog); cell activation (ortholog); PARTICIPATES IN interleukin-6 signaling pathway; ASSOCIATED WITH adrenoleukodystrophy (ortholog); adult respiratory distress syndrome (ortholog); alcoholic liver cirrhosis (ortholog); FOUND IN basement membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: metalloproteinase inhibitor 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X33,505,193 - 33,509,420 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493650213,345,936 - 13,350,170 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adrenoleukodystrophy  (ISO)
adult respiratory distress syndrome  (ISO)
alcoholic liver cirrhosis  (ISO)
Animal Disease Models  (ISO)
aortic valve insufficiency  (ISO)
autistic disorder  (ISO)
autoimmune disease  (ISO)
Brain Injuries  (ISO)
breast cancer  (ISO)
CAKUT2  (ISO)
calcinosis  (ISO)
cholangitis  (ISO)
cholestasis  (ISO)
chronic obstructive pulmonary disease  (ISO)
congestive heart failure  (ISO)
COVID-19  (ISO)
cystic fibrosis  (ISO)
degenerative disc disease  (ISO)
diabetes mellitus  (ISO)
Down syndrome  (ISO)
Emphysema  (ISO)
endometrial carcinoma  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (ISO)
extrahepatic cholestasis  (ISO)
Female Urogenital Diseases  (ISO)
gastric ulcer  (ISO)
heart disease  (ISO)
heart valve disease  (ISO)
hyperhomocysteinemia  (ISO)
Hyperoxia  (ISO)
hypertension  (ISO)
IgA glomerulonephritis  (ISO)
Inflammation  (ISO)
intracranial aneurysm  (ISO)
Kawasaki disease  (ISO)
Lymphatic Metastasis  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
obesity  (ISO)
oral submucous fibrosis  (ISO)
ovarian cancer  (ISO)
pre-eclampsia  (ISO)
preretinal fibrosis  (ISO)
pulmonary fibrosis  (ISO)
relapsing-remitting multiple sclerosis  (ISO)
renal cell carcinoma  (ISO)
Stroke  (ISO)
syndromic X-linked intellectual disability Lubs type  (ISO)
thoracic aortic aneurysm  (ISO)
transitional cell carcinoma  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
varicose veins  (ISO)
vascular disease  (ISO)
Wilson disease  (ISO)
Wounds and Injuries  (ISO)
X-linked epilepsy with variable learning disabilities and behavior disorders  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
Timp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X33,505,193 - 33,509,420 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493650213,345,936 - 13,350,170 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TIMP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X47,582,436 - 47,586,789 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX47,582,408 - 47,586,789 (+)EnsemblGRCh38hg38GRCh38
GRCh37X47,441,835 - 47,446,188 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X47,326,634 - 47,331,134 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X47,198,084 - 47,202,441NCBI
CeleraX51,636,947 - 51,641,447 (+)NCBICelera
Cytogenetic MapXp11.3NCBI
HuRefX45,154,211 - 45,158,632 (+)NCBIHuRef
CHM1_1X47,472,792 - 47,477,292 (+)NCBICHM1_1
T2T-CHM13v2.0X46,992,326 - 46,996,679 (+)NCBIT2T-CHM13v2.0
Timp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X20,736,405 - 20,740,976 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX20,736,405 - 20,740,974 (+)EnsemblGRCm39 Ensembl
GRCm38X20,870,166 - 20,874,737 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX20,870,166 - 20,874,735 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X20,447,292 - 20,451,863 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X20,027,998 - 20,031,591 (+)NCBIMGSCv36mm8
CeleraX19,001,307 - 19,005,878 (+)NCBICelera
Cytogenetic MapXA1.3NCBI
cM MapX16.38NCBI
Timp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X1,212,969 - 1,217,714 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX1,212,972 - 1,217,664 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX1,241,133 - 1,245,729 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0X4,716,824 - 4,721,420 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0X1,037,983 - 1,042,580 (-)NCBIRnor_WKY
Rnor_6.0X1,364,771 - 1,369,451 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX1,364,786 - 1,369,384 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X2,179,962 - 2,184,814 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X12,542,496 - 12,547,094 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X12,548,051 - 12,552,650 (-)NCBI
CeleraX1,780,586 - 1,785,184 (-)NCBICelera
Cytogenetic MapXq11NCBI
Timp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955516505,789 - 512,118 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955516507,113 - 511,360 (-)NCBIChiLan1.0ChiLan1.0
TIMP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X47,914,906 - 47,919,419 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX47,914,906 - 47,919,419 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X40,018,190 - 40,022,636 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
TIMP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X41,201,623 - 41,205,314 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX41,201,638 - 41,205,310 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX15,576,764 - 15,580,333 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X41,335,929 - 41,339,499 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX41,335,826 - 41,339,498 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X41,323,532 - 41,327,103 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X41,311,800 - 41,315,371 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X41,404,449 - 41,408,018 (+)NCBIUU_Cfam_GSD_1.0
TIMP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX42,102,172 - 42,106,296 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X42,103,251 - 42,106,289 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X47,372,604 - 47,375,643 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig CytomapXpNCBI
LOC103231892
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X44,759,412 - 44,763,243 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX44,760,531 - 44,765,571 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366656624,012 - 27,843 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Timp1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624978121,803 - 124,912 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624978120,723 - 125,006 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005324024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: XM_005324024   ⟹   XP_005324081
RefSeq Status:
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2X33,505,193 - 33,509,420 (+)NCBI
SpeTri2.0NW_00493650213,345,936 - 13,350,170 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005324081 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein KAG3272027 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005324081   ⟸   XM_005324024
- UniProtKB: I3M740 (UniProtKB/TrEMBL)
- Sequence:
Protein Domains
NTR


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000006013 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSTOP00000005370 ENTREZGENE
  ENSSTOP00000005370.2 UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000006002.3 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.120 UniProtKB/TrEMBL
  3.90.370.10 UniProtKB/TrEMBL
InterPro Netrin_domain UniProtKB/TrEMBL
  TIMP UniProtKB/TrEMBL
  TIMP-like_OB-fold UniProtKB/TrEMBL
  TIMP1 UniProtKB/TrEMBL
  TIMP_C UniProtKB/TrEMBL
  TIMP_CS UniProtKB/TrEMBL
NCBI Gene Timp1 ENTREZGENE
PANTHER PTHR11844 UniProtKB/TrEMBL
  PTHR11844:SF20 UniProtKB/TrEMBL
Pfam TIMP UniProtKB/TrEMBL
PROSITE NTR UniProtKB/TrEMBL
  TIMP UniProtKB/TrEMBL
SMART NTR UniProtKB/TrEMBL
Superfamily-SCOP SSF50242 UniProtKB/TrEMBL
UniProt I3M740 ENTREZGENE, UniProtKB/TrEMBL