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Gene: IL12A (interleukin 12A) Homo sapiens
Symbol: IL12A
Name: interleukin 12A
Description: This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CLMF; CLMF p35; cytotoxic lymphocyte maturation factor 1, p35; cytotoxic lymphocyte maturation factor 35 kDa subunit; IL-12 subunit p35; IL-12, subunit p35; IL-12A; IL35 subunit; interleukin 12, p35; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35); interleukin-12 alpha chain; interleukin-12 subunit alpha; natural killer cell stimulatory factor 1, 35 kD subunit; NF cell stimulatory factor chain 1; NFSK; NK cell stimulatory factor chain 1; NKSF1; P35
Mus musculus (house mouse) : Il12a (interleukin 12a)  MGI  Alliance
Rattus norvegicus (Norway rat) : Il12a (interleukin 12A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Il12a (interleukin 12A)
Pan paniscus (bonobo/pygmy chimpanzee) : IL12A (interleukin 12A)
Canis lupus familiaris (dog) : IL12A (interleukin 12A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Il12a (interleukin 12A)
Sus scrofa (pig) : IL12A (interleukin 12A)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh383159,988,835 - 159,996,019 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373159,706,623 - 159,713,806 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363161,189,323 - 161,196,500 (+)NCBINCBI36hg18NCBI36
Build 343161,189,330 - 161,196,507NCBI
Celera3158,128,398 - 158,135,579 (+)NCBI
Cytogenetic Map3q25.33NCBI
HuRef3157,102,994 - 157,110,193 (+)NCBIHuRef
CHM1_13159,669,641 - 159,676,836 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on IL12A
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1351047
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2019-10-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.