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Gene: IGFBP3 (insulin like growth factor binding protein 3) Homo sapiens
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Symbol: IGFBP3
Name: insulin like growth factor binding protein 3
Description: Exhibits insulin-like growth factor I binding activity and protein tyrosine phosphatase activator activity. Involved in several processes, including negative regulation of smooth muscle cell migration; negative regulation of smooth muscle cell proliferation; and positive regulation of myoblast differentiation. Localizes to the insulin-like growth factor ternary complex and nucleus. Implicated in several diseases, including Alzheimer's disease; Turner syndrome; diabetes mellitus (multiple); prostate cancer; and transitional cell carcinoma. Biomarker of several diseases, including Barrett's esophagus; Down syndrome; autoimmune hypersensitivity disease (multiple); bone inflammation disease (multiple); and urinary system cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: acid stable subunit of the 140 K IGF complex; binding protein 29; binding protein 53; BP-53; growth hormone-dependent binding protein; IBP-3; IBP3; IGF-binding protein 3; IGFBP-3; insulin-like growth factor binding protein 3; insulin-like growth factor-binding protein 3
Orthologs:
Mus musculus (house mouse) : Igfbp3 (insulin-like growth factor binding protein 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Igfbp3 (insulin-like growth factor binding protein 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Igfbp3 (insulin like growth factor binding protein 3)
Pan paniscus (bonobo/pygmy chimpanzee) : IGFBP3 (insulin like growth factor binding protein 3)
Canis lupus familiaris (dog) : IGFBP3 (insulin like growth factor binding protein 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Igfbp3 (insulin like growth factor binding protein 3)
Sus scrofa (pig) : IGFBP3 (insulin like growth factor binding protein 3)
Chlorocebus sabaeus (African green monkey) : IGFBP3 (insulin like growth factor binding protein 3)
Heterocephalus glaber (naked mole-rat) : Igfbp3 (insulin like growth factor binding protein 3)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl745,912,245 - 45,921,874 (-)EnsemblGRCh38hg38GRCh38
GRCh38745,912,245 - 45,921,272 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37745,951,844 - 45,960,871 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36745,918,369 - 45,927,396 (-)NCBINCBI36hg18NCBI36
Build 34745,725,189 - 45,734,057NCBI
Celera746,050,761 - 46,059,785 (-)NCBI
Cytogenetic Map7p12.3NCBI
HuRef745,836,799 - 45,845,824 (-)NCBIHuRef
CHM1_1745,956,047 - 45,965,072 (-)NCBICHM1_1
CRA_TCAGchr7v2745,991,173 - 46,000,198 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
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References - uncurated

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miRNA Target Status

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RNA-SEQ Expression

Sequence

Nucleotide Sequences
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Additional Information

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Nomenclature History
 
More on IGFBP3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 736042
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-03-10
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.