WNT8A (Wnt family member 8A) - Rat Genome Database

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Gene: WNT8A (Wnt family member 8A) Homo sapiens
Analyze
Symbol: WNT8A
Name: Wnt family member 8A
RGD ID: 1314861
HGNC Page HGNC:12788
Description: Enables receptor ligand activity. Involved in canonical Wnt signaling pathway and secondary palate development. Predicted to be located in collagen-containing extracellular matrix. Predicted to be active in extracellular space.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: wingless-type MMTV integration site family member 8A; wingless-type MMTV integration site family, member 8A; Wnt-8a; Wnt-8d; WNT8D
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385138,077,367 - 138,092,365 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5138,083,990 - 138,092,365 (+)EnsemblGRCh38hg38GRCh38
GRCh375137,419,722 - 137,428,054 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365137,447,673 - 137,455,098 (+)NCBINCBI36Build 36hg18NCBI36
Build 345137,447,577 - 137,455,953NCBI
Celera5133,541,722 - 133,549,145 (+)NCBICelera
Cytogenetic Map5q31.2NCBI
HuRef5132,610,733 - 132,618,179 (+)NCBIHuRef
CHM1_15136,852,364 - 136,859,793 (+)NCBICHM1_1
T2T-CHM13v2.05138,603,716 - 138,618,708 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Hypospadias  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. The Wnt Homepage Roel Nusse - Howard Hughes Medical Institute and the Department of Developmental Biology at Stanford University, California, USA
6. Alternative wnt signaling is initiated by distinct receptors. van Amerongen R, etal., Sci Signal. 2008 Sep 2;1(35):re9.
Additional References at PubMed
PMID:8167409   PMID:11408932   PMID:11956596   PMID:12477932   PMID:18413325   PMID:20559569   PMID:20890934   PMID:21873635   PMID:22544366   PMID:22889411   PMID:23836442   PMID:27634302  
PMID:28733458   PMID:30060804   PMID:33357447   PMID:33961781  


Genomics

Comparative Map Data
WNT8A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385138,077,367 - 138,092,365 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5138,083,990 - 138,092,365 (+)EnsemblGRCh38hg38GRCh38
GRCh375137,419,722 - 137,428,054 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365137,447,673 - 137,455,098 (+)NCBINCBI36Build 36hg18NCBI36
Build 345137,447,577 - 137,455,953NCBI
Celera5133,541,722 - 133,549,145 (+)NCBICelera
Cytogenetic Map5q31.2NCBI
HuRef5132,610,733 - 132,618,179 (+)NCBIHuRef
CHM1_15136,852,364 - 136,859,793 (+)NCBICHM1_1
T2T-CHM13v2.05138,603,716 - 138,618,708 (+)NCBIT2T-CHM13v2.0
Wnt8a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391834,675,380 - 34,681,114 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1834,675,366 - 34,681,326 (+)EnsemblGRCm39 Ensembl
GRCm381834,542,327 - 34,548,061 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1834,542,313 - 34,548,273 (+)EnsemblGRCm38mm10GRCm38
MGSCv371834,701,982 - 34,707,715 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361834,667,114 - 34,673,074 (+)NCBIMGSCv36mm8
Celera1834,995,948 - 35,001,675 (+)NCBICelera
Cytogenetic Map18B1NCBI
cM Map1818.69NCBI
Wnt8a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81826,411,833 - 26,417,426 (+)NCBIGRCr8
mRatBN7.21826,137,690 - 26,143,283 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1826,137,690 - 26,143,283 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1826,265,080 - 26,270,673 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01827,028,812 - 27,034,426 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01826,363,713 - 26,369,327 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01827,331,236 - 27,336,829 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1827,331,236 - 27,336,829 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01827,044,608 - 27,050,201 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41827,007,156 - 27,012,749 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11827,029,469 - 27,038,824 (+)NCBI
Celera1825,876,225 - 25,881,818 (+)NCBICelera
Cytogenetic Map18p12NCBI
Wnt8a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554182,332,636 - 2,338,085 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554182,332,636 - 2,338,099 (-)NCBIChiLan1.0ChiLan1.0
WNT8A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24133,354,550 - 133,367,296 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15131,494,107 - 131,506,856 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05133,419,324 - 133,471,094 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15139,598,229 - 139,605,926 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5139,598,229 - 139,605,926 (+)Ensemblpanpan1.1panPan2
WNT8A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11125,707,058 - 25,752,724 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1125,744,780 - 25,749,748 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1124,470,773 - 24,519,397 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01126,556,926 - 26,605,507 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1126,558,406 - 26,603,592 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11125,264,436 - 25,313,063 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01125,088,231 - 25,136,559 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01125,751,347 - 25,800,034 (+)NCBIUU_Cfam_GSD_1.0
Wnt8a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213154,332,315 - 154,337,724 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365317,273,882 - 7,278,959 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365317,273,681 - 7,279,394 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WNT8A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2140,103,830 - 140,109,862 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12140,103,322 - 140,113,682 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22145,777,794 - 145,784,671 (+)NCBISscrofa10.2Sscrofa10.2susScr3
WNT8A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12340,750,907 - 40,759,421 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2340,751,780 - 40,758,790 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603437,130,575 - 37,139,750 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wnt8a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474330,890,359 - 30,895,682 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474330,852,463 - 30,896,443 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in WNT8A
21 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 5q23.3-33.2(chr5:130860928-155321811)x3 copy number gain See cases [RCV000051193] Chr5:130860928..155321811 [GRCh38]
Chr5:130196621..154701371 [GRCh37]
Chr5:130224520..154681564 [NCBI36]
Chr5:5q23.3-33.2
pathogenic
GRCh38/hg38 5q31.1-31.2(chr5:133401565-138437038)x1 copy number loss See cases [RCV000052114] Chr5:133401565..138437038 [GRCh38]
Chr5:132737257..137772727 [GRCh37]
Chr5:132765156..137800626 [NCBI36]
Chr5:5q31.1-31.2
pathogenic
GRCh38/hg38 5q21.3-33.2(chr5:106619588-156124387)x1 copy number loss See cases [RCV000053524] Chr5:106619588..156124387 [GRCh38]
Chr5:105955289..155551397 [GRCh37]
Chr5:105983188..155483975 [NCBI36]
Chr5:5q21.3-33.2
pathogenic
NM_058244.3(WNT8A):c.801C>T (p.Ile267=) single nucleotide variant Malignant melanoma [RCV000066638] Chr5:138090818 [GRCh38]
Chr5:137426507 [GRCh37]
Chr5:137454406 [NCBI36]
Chr5:5q31.2
not provided
NM_058244.3(WNT8A):c.1044G>A (p.Lys348=) single nucleotide variant Malignant melanoma [RCV000061111] Chr5:138091061 [GRCh38]
Chr5:137426750 [GRCh37]
Chr5:137454649 [NCBI36]
Chr5:5q31.2
not provided
GRCh38/hg38 5q31.1-31.3(chr5:135297294-140106003)x3 copy number gain See cases [RCV000133750] Chr5:135297294..140106003 [GRCh38]
Chr5:134632984..139485588 [GRCh37]
Chr5:134660883..139465772 [NCBI36]
Chr5:5q31.1-31.3
pathogenic
GRCh38/hg38 5q31.2-31.3(chr5:137836682-140696361)x3 copy number gain See cases [RCV000134725] Chr5:137836682..140696361 [GRCh38]
Chr5:137172371..140075946 [GRCh37]
Chr5:137200270..140056130 [NCBI36]
Chr5:5q31.2-31.3
pathogenic
GRCh38/hg38 5q23.3-33.2(chr5:129847794-153353546)x3 copy number gain See cases [RCV000138808] Chr5:129847794..153353546 [GRCh38]
Chr5:129183487..152733106 [GRCh37]
Chr5:129211386..152713299 [NCBI36]
Chr5:5q23.3-33.2
pathogenic
GRCh37/hg19 5q15-35.3(chr5:94844077-178830410)x3 copy number gain not provided [RCV000487658] Chr5:94844077..178830410 [GRCh37]
Chr5:5q15-35.3
likely benign
GRCh37/hg19 5q23.3-33.3(chr5:130125085-157574910)x3 copy number gain See cases [RCV000449349] Chr5:130125085..157574910 [GRCh37]
Chr5:5q23.3-33.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789) copy number gain See cases [RCV000510723] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5q21.3-35.3(chr5:106716357-180687338)x3 copy number gain See cases [RCV000448245] Chr5:106716357..180687338 [GRCh37]
Chr5:5q21.3-35.3
pathogenic
NC_000005.9:g.(?_86400000)_(154000000_?)del deletion Familial adenomatous polyposis 1 [RCV002231249]|Hereditary cancer-predisposing syndrome [RCV000554476] Chr5:86400000..154000000 [GRCh37]
Chr5:5q14.3-33.2
pathogenic
GRCh37/hg19 5p15.1-q35.2(chr5:17628741-176575720)x1 copy number loss See cases [RCV000511978] Chr5:17628741..176575720 [GRCh37]
Chr5:5p15.1-q35.2
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789)x3 copy number gain See cases [RCV000512039] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
NM_001300939.2(WNT8A):c.698C>T (p.Ala233Val) single nucleotide variant Inborn genetic diseases [RCV003273764] Chr5:138090661 [GRCh38]
Chr5:137426350 [GRCh37]
Chr5:5q31.2
uncertain significance
GRCh37/hg19 5p15.33-q35.3(chr5:13648-180905029)x3 copy number gain not provided [RCV000744317] Chr5:13648..180905029 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:25328-180693344)x3 copy number gain not provided [RCV000744323] Chr5:25328..180693344 [GRCh37]
Chr5:5p15.33-q35.3
pathogenic
Single allele deletion Neurodevelopmental disorder [RCV000787436] Chr5:14685137..149511942 [GRCh37]
Chr5:5p15.2-q32
uncertain significance
NC_000005.9:g.(?_136633338)_(140998481_?)dup duplication PURA-related severe neonatal hypotonia-seizures-encephalopathy syndrome [RCV001339088] Chr5:136633338..140998481 [GRCh37]
Chr5:5q31.2-31.3
uncertain significance
GRCh37/hg19 5q31.2(chr5:136409875-137739167) copy number loss Microcephaly [RCV001352638] Chr5:136409875..137739167 [GRCh37]
Chr5:5q31.2
pathogenic
GRCh37/hg19 5q23.3-33.3(chr5:130125085-157574910) copy number gain not specified [RCV002053526] Chr5:130125085..157574910 [GRCh37]
Chr5:5q23.3-33.3
pathogenic
NM_001300939.2(WNT8A):c.142A>G (p.Ile48Val) single nucleotide variant Hypospadias [RCV001824103] Chr5:138084269 [GRCh38]
Chr5:137419958 [GRCh37]
Chr5:5q31.2
uncertain significance
GRCh37/hg19 5q31.1-31.2(chr5:132031902-137623639) copy number loss not specified [RCV002053530] Chr5:132031902..137623639 [GRCh37]
Chr5:5q31.1-31.2
pathogenic
NC_000005.9:g.(?_136957787)_(140078137_?)dup duplication PURA-related severe neonatal hypotonia-seizures-encephalopathy syndrome [RCV003116437] Chr5:136957787..140078137 [GRCh37]
Chr5:5q31.2-31.3
uncertain significance
NC_000005.9:g.(?_136957787)_(138861289_?)del deletion STING-associated vasculopathy with onset in infancy [RCV003113978] Chr5:136957787..138861289 [GRCh37]
Chr5:5q31.2
uncertain significance
NM_001300939.2(WNT8A):c.1052A>G (p.Lys351Arg) single nucleotide variant Inborn genetic diseases [RCV003259733] Chr5:138091015 [GRCh38]
Chr5:137426704 [GRCh37]
Chr5:5q31.2
uncertain significance
NM_001300939.2(WNT8A):c.239G>T (p.Arg80Leu) single nucleotide variant Inborn genetic diseases [RCV002945480] Chr5:138084580 [GRCh38]
Chr5:137420269 [GRCh37]
Chr5:5q31.2
uncertain significance
NM_001300939.2(WNT8A):c.152C>A (p.Pro51His) single nucleotide variant Inborn genetic diseases [RCV002777523] Chr5:138084279 [GRCh38]
Chr5:137419968 [GRCh37]
Chr5:5q31.2
uncertain significance
NM_001300939.2(WNT8A):c.772G>A (p.Ala258Thr) single nucleotide variant Inborn genetic diseases [RCV002799281] Chr5:138090735 [GRCh38]
Chr5:137426424 [GRCh37]
Chr5:5q31.2
uncertain significance
NM_001300939.2(WNT8A):c.592T>G (p.Cys198Gly) single nucleotide variant Inborn genetic diseases [RCV002951716] Chr5:138090555 [GRCh38]
Chr5:137426244 [GRCh37]
Chr5:5q31.2
uncertain significance
NM_001300939.2(WNT8A):c.173C>T (p.Thr58Met) single nucleotide variant Inborn genetic diseases [RCV002951638] Chr5:138084514 [GRCh38]
Chr5:137420203 [GRCh37]
Chr5:5q31.2
uncertain significance
NM_001300939.2(WNT8A):c.197A>C (p.Gln66Pro) single nucleotide variant Inborn genetic diseases [RCV002930446] Chr5:138084538 [GRCh38]
Chr5:137420227 [GRCh37]
Chr5:5q31.2
uncertain significance
NM_001300939.2(WNT8A):c.799C>A (p.Leu267Met) single nucleotide variant Inborn genetic diseases [RCV002767952] Chr5:138090762 [GRCh38]
Chr5:137426451 [GRCh37]
Chr5:5q31.2
uncertain significance
NM_001300939.2(WNT8A):c.757T>C (p.Trp253Arg) single nucleotide variant Inborn genetic diseases [RCV002742060] Chr5:138090720 [GRCh38]
Chr5:137426409 [GRCh37]
Chr5:5q31.2
uncertain significance
NM_001300939.2(WNT8A):c.872G>A (p.Arg291His) single nucleotide variant Inborn genetic diseases [RCV002916928] Chr5:138090835 [GRCh38]
Chr5:137426524 [GRCh37]
Chr5:5q31.2
uncertain significance
NM_001300939.2(WNT8A):c.748G>A (p.Glu250Lys) single nucleotide variant Inborn genetic diseases [RCV003004135] Chr5:138090711 [GRCh38]
Chr5:137426400 [GRCh37]
Chr5:5q31.2
uncertain significance
NM_001300939.2(WNT8A):c.886A>T (p.Asn296Tyr) single nucleotide variant Inborn genetic diseases [RCV002789534] Chr5:138090849 [GRCh38]
Chr5:137426538 [GRCh37]
Chr5:5q31.2
uncertain significance
NM_001300939.2(WNT8A):c.384A>T (p.Glu128Asp) single nucleotide variant Inborn genetic diseases [RCV002764007] Chr5:138087894 [GRCh38]
Chr5:137423583 [GRCh37]
Chr5:5q31.2
uncertain significance
NM_001300939.2(WNT8A):c.536A>C (p.Asn179Thr) single nucleotide variant Inborn genetic diseases [RCV002679273] Chr5:138089041 [GRCh38]
Chr5:137424730 [GRCh37]
Chr5:5q31.2
uncertain significance
NM_001300939.2(WNT8A):c.929G>A (p.Arg310His) single nucleotide variant Inborn genetic diseases [RCV003283728] Chr5:138090892 [GRCh38]
Chr5:137426581 [GRCh37]
Chr5:5q31.2
uncertain significance
NM_001300939.2(WNT8A):c.-32A>G single nucleotide variant Inborn genetic diseases [RCV003173110] Chr5:138084096 [GRCh38]
Chr5:137419785 [GRCh37]
Chr5:5q31.2
likely benign
NM_001300939.2(WNT8A):c.-5G>A single nucleotide variant Inborn genetic diseases [RCV003365873] Chr5:138084123 [GRCh38]
Chr5:137419812 [GRCh37]
Chr5:5q31.2
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:573
Count of miRNA genes:372
Interacting mature miRNAs:399
Transcripts:ENST00000361560, ENST00000398754, ENST00000504809, ENST00000506684
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium 3 20 1
Low 3 2 2 1 15 1 89 1 662 4 385 2
Below cutoff 645 638 636 87 465 34 1453 554 2287 76 472 546 53 302 1001

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001300938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001300939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_058244 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_125351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011543625 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017009824 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017009825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017009826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047417692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047417693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054353426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054353427 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054353428 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB057725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC113382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY009402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC144001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC144497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CQ970126 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000361560   ⟹   ENSP00000354726
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5138,083,990 - 138,092,365 (+)Ensembl
RefSeq Acc Id: ENST00000398754   ⟹   ENSP00000381739
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5138,084,085 - 138,091,510 (+)Ensembl
RefSeq Acc Id: ENST00000504809   ⟹   ENSP00000424809
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5138,084,015 - 138,091,459 (+)Ensembl
RefSeq Acc Id: ENST00000506684   ⟹   ENSP00000426653
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5138,084,033 - 138,091,541 (+)Ensembl
RefSeq Acc Id: NM_001300938   ⟹   NP_001287867
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385138,084,033 - 138,091,541 (+)NCBI
CHM1_15136,852,171 - 136,859,824 (+)NCBI
T2T-CHM13v2.05138,610,381 - 138,617,888 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001300939   ⟹   NP_001287868
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385138,084,033 - 138,091,541 (+)NCBI
CHM1_15136,852,171 - 136,859,824 (+)NCBI
T2T-CHM13v2.05138,610,381 - 138,617,888 (+)NCBI
Sequence:
RefSeq Acc Id: NM_058244   ⟹   NP_490645
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385138,084,033 - 138,091,541 (+)NCBI
GRCh375137,419,581 - 137,428,337 (+)NCBI
Build 365137,447,673 - 137,455,098 (+)NCBI Archive
Celera5133,541,722 - 133,549,145 (+)RGD
HuRef5132,610,733 - 132,618,179 (+)ENTREZGENE
CHM1_15136,852,171 - 136,859,824 (+)NCBI
T2T-CHM13v2.05138,610,381 - 138,617,888 (+)NCBI
Sequence:
RefSeq Acc Id: NR_125351
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385138,084,033 - 138,092,365 (+)NCBI
CHM1_15136,852,171 - 136,860,648 (+)NCBI
T2T-CHM13v2.05138,610,381 - 138,618,708 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017009826   ⟹   XP_016865315
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385138,077,367 - 138,091,541 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047417692   ⟹   XP_047273648
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385138,077,367 - 138,091,541 (+)NCBI
RefSeq Acc Id: XM_047417693   ⟹   XP_047273649
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385138,079,821 - 138,091,541 (+)NCBI
RefSeq Acc Id: XM_054353426   ⟹   XP_054209401
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.05138,603,716 - 138,617,888 (+)NCBI
RefSeq Acc Id: XM_054353427   ⟹   XP_054209402
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.05138,603,716 - 138,617,888 (+)NCBI
RefSeq Acc Id: XM_054353428   ⟹   XP_054209403
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.05138,606,170 - 138,617,888 (+)NCBI
RefSeq Acc Id: NP_490645   ⟸   NM_058244
- Peptide Label: isoform 3 precursor
- UniProtKB: Q96S51 (UniProtKB/Swiss-Prot),   Q9H1J5 (UniProtKB/Swiss-Prot),   D6RF94 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001287868   ⟸   NM_001300939
- Peptide Label: isoform 2 precursor
- UniProtKB: D6RF47 (UniProtKB/TrEMBL),   D6RF94 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001287867   ⟸   NM_001300938
- Peptide Label: isoform 1 precursor
- UniProtKB: D6RF94 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016865315   ⟸   XM_017009826
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSP00000381739   ⟸   ENST00000398754
RefSeq Acc Id: ENSP00000424809   ⟸   ENST00000504809
RefSeq Acc Id: ENSP00000426653   ⟸   ENST00000506684
RefSeq Acc Id: ENSP00000354726   ⟸   ENST00000361560
RefSeq Acc Id: XP_047273648   ⟸   XM_047417692
- Peptide Label: isoform X1
RefSeq Acc Id: XP_047273649   ⟸   XM_047417693
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054209402   ⟸   XM_054353427
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054209401   ⟸   XM_054353426
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054209403   ⟸   XM_054353428
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9H1J5-F1-model_v2 AlphaFold Q9H1J5 1-351 view protein structure

Promoters
RGD ID:6870682
Promoter ID:EPDNEW_H8506
Type:initiation region
Name:WNT8A_1
Description:Wnt family member 8A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh385138,083,914 - 138,083,974EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:12788 AgrOrtholog
COSMIC WNT8A COSMIC
Ensembl Genes ENSG00000061492 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000361560 ENTREZGENE
  ENST00000361560.6 UniProtKB/Swiss-Prot
  ENST00000398754 ENTREZGENE
  ENST00000398754.1 UniProtKB/Swiss-Prot
  ENST00000504809 ENTREZGENE
  ENST00000504809.5 UniProtKB/TrEMBL
  ENST00000506684 ENTREZGENE
  ENST00000506684.6 UniProtKB/TrEMBL
Gene3D-CATH 3.30.2460.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000061492 GTEx
HGNC ID HGNC:12788 ENTREZGENE
Human Proteome Map WNT8A Human Proteome Map
InterPro Protein_Wnt-8A/8C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Wnt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Wnt8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Wnt_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Wnt_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:7478 UniProtKB/Swiss-Prot
NCBI Gene 7478 ENTREZGENE
OMIM 606360 OMIM
PANTHER PTHR12027 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12027:SF92 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam wnt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA37389 PharmGKB
PRINTS WNT8PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WNTPROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE WNT1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART WNT1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D6RF47 ENTREZGENE, UniProtKB/TrEMBL
  D6RF94 ENTREZGENE, UniProtKB/TrEMBL
  Q96S51 ENTREZGENE
  Q9H1J5 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q96S51 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-28 WNT8A  Wnt family member 8A  WNT8A  wingless-type MMTV integration site family member 8A  Symbol and/or name change 5135510 APPROVED
2015-11-24 WNT8A  wingless-type MMTV integration site family member 8A  WNT8A  wingless-type MMTV integration site family, member 8A  Symbol and/or name change 5135510 APPROVED