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Gene: TNFSF10 (TNF superfamily member 10) Homo sapiens
Symbol: TNFSF10
Name: TNF superfamily member 10
Description: Exhibits identical protein binding activity and zinc ion binding activity. Involved in positive regulation of I-kappaB kinase/NF-kappaB signaling and positive regulation of apoptotic process. Localizes to extracellular exosome. Implicated in arteriosclerosis and small cell carcinoma. Biomarker of type 1 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Apo-2 ligand; Apo-2L; APO2L; CD253; chemokine tumor necrosis factor ligand superfamily member 10; TL2; TNF-related apoptosis inducing ligand TRAIL; TNF-related apoptosis-inducing ligand; TNLG6A; TRAIL; tumor necrosis factor (ligand) family, member 10; tumor necrosis factor (ligand) superfamily member 10; tumor necrosis factor (ligand) superfamily, member 10; tumor necrosis factor apoptosis-inducing ligand splice variant delta; tumor necrosis factor ligand 6A; tumor necrosis factor ligand superfamily member 10; tumor necrosis factor superfamily member 10
Mus musculus (house mouse) : Tnfsf10 (tumor necrosis factor (ligand) superfamily, member 10)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tnfsf10 (TNF superfamily member 10)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tnfsf10 (TNF superfamily member 10)
Pan paniscus (bonobo/pygmy chimpanzee) : TNFSF10 (TNF superfamily member 10)
Canis lupus familiaris (dog) : TNFSF10 (TNF superfamily member 10)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tnfsf10 (TNF superfamily member 10)
Sus scrofa (pig) : TNFSF10 (TNF superfamily member 10)
Chlorocebus sabaeus (African green monkey) : TNFSF10 (TNF superfamily member 10)
Heterocephalus glaber (naked mole-rat) : Tnfsf10 (TNF superfamily member 10)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl3172,505,508 - 172,523,475 (-)EnsemblGRCh38hg38GRCh38
GRCh383172,505,508 - 172,523,430 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373172,223,298 - 172,241,297 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363173,706,158 - 173,723,963 (-)NCBINCBI36hg18NCBI36
Build 343173,706,166 - 173,723,971NCBI
Celera3170,621,889 - 170,639,888 (-)NCBI
Cytogenetic Map3q26.31NCBI
HuRef3169,593,908 - 169,611,904 (-)NCBIHuRef
CHM1_13172,186,184 - 172,204,170 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TNFSF10
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1344832
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-06-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.