TNFSF10 (TNF superfamily member 10) - Rat Genome Database

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Gene: TNFSF10 (TNF superfamily member 10) Homo sapiens
Analyze
Symbol: TNFSF10
Name: TNF superfamily member 10
RGD ID: 1344832
HGNC Page HGNC
Description: Enables identical protein binding activity and zinc ion binding activity. Involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of release of cytochrome c from mitochondria; and positive regulation of signal transduction. Located in extracellular exosome. Implicated in arteriosclerosis and small cell carcinoma. Biomarker of type 1 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Apo-2 ligand; Apo-2L; APO2L; CD253; chemokine tumor necrosis factor ligand superfamily member 10; TL2; TNF-related apoptosis inducing ligand TRAIL; TNF-related apoptosis-inducing ligand; TNLG6A; TRAIL; tumor necrosis factor (ligand) family, member 10; tumor necrosis factor (ligand) superfamily member 10; tumor necrosis factor (ligand) superfamily, member 10; tumor necrosis factor apoptosis-inducing ligand splice variant delta; tumor necrosis factor ligand 6A; tumor necrosis factor ligand superfamily member 10; tumor necrosis factor superfamily member 10
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3172,505,508 - 172,523,475 (-)EnsemblGRCh38hg38GRCh38
GRCh383172,505,508 - 172,523,430 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373172,223,298 - 172,241,220 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363173,706,158 - 173,723,963 (-)NCBINCBI36hg18NCBI36
Build 343173,706,166 - 173,723,971NCBI
Celera3170,621,889 - 170,639,888 (-)NCBI
Cytogenetic Map3q26.31NCBI
HuRef3169,593,908 - 169,611,904 (-)NCBIHuRef
CHM1_13172,186,184 - 172,204,170 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(+)-schisandrin B  (ISO)
(-)-demecolcine  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(R)-lipoic acid  (ISO)
(R)-mevalonic acid  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (EXP)
2,4,6-trinitrotoluene  (ISO)
2-hydroxypropanoic acid  (EXP)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,5,6,7-TETRABROMOBENZOTRIAZOLE  (EXP)
4-\{[(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino\}benzoic acid  (EXP)
4-hydroxyphenyl retinamide  (EXP,ISO)
5-aza-2'-deoxycytidine  (EXP)
5-azacytidine  (EXP,ISO)
5-fluorouracil  (EXP,ISO)
8'-apo-beta,psi-caroten-8'-al  (EXP)
9-cis-retinoic acid  (EXP)
[6]-Shogaol  (EXP)
acetamide  (ISO)
acetylsalicylic acid  (EXP,ISO)
actinomycin D  (EXP)
adenosine  (ISO)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (EXP)
aluminium oxide  (EXP)
alvocidib  (EXP)
amiloride  (EXP)
amiodarone  (EXP)
ammonium chloride  (ISO)
amphetamine  (ISO)
amphibole asbestos  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antimony(0)  (EXP)
antirheumatic drug  (EXP)
apigenin  (EXP)
aripiprazole  (EXP)
aristolochic acid  (EXP)
Aroclor 1254  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenous acid  (EXP)
atazanavir sulfate  (EXP)
atorvastatin calcium  (EXP)
atrazine  (ISO)
Auriculasin  (EXP)
beauvericin  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
bepridil  (EXP)
beta-carotene  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
bortezomib  (EXP,ISO)
brefeldin A  (EXP)
buta-1,3-diene  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
Calcimycin  (EXP)
cantharidin  (EXP)
capsaicin  (EXP,ISO)
carbon nanotube  (EXP,ISO)
carboxy-PTIO  (EXP)
carmustine  (EXP)
casticin  (EXP)
celastrol  (EXP)
celecoxib  (EXP)
chenodeoxycholic acid  (EXP)
chloroprene  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
chromium atom  (EXP)
chromium(6+)  (ISO)
chrysazin  (EXP)
chrysene  (ISO)
chrysin  (EXP)
cibenzoline  (EXP)
cisplatin  (EXP,ISO)
cocaine  (ISO)
coformycin  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP)
crocidolite asbestos  (EXP)
curcumin  (EXP)
cycloheximide  (EXP)
cyclosporin A  (EXP)
cylindrospermopsin  (EXP)
cytarabine  (EXP)
D-glucose  (EXP)
dacarbazine  (EXP)
daunorubicin  (EXP)
deoxycholic acid  (EXP)
dexamethasone  (EXP)
diallyl disulfide  (EXP)
diallyl trisulfide  (EXP)
diarsenic trioxide  (EXP)
dibenz[a,h]anthracene  (ISO)
dichloroacetic acid  (ISO)
dichromium trioxide  (EXP)
dicrotophos  (EXP)
diethylstilbestrol  (ISO)
dihydroxyacetone  (EXP)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (EXP)
disodium selenite  (EXP)
dopamine  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (EXP)
endosulfan  (ISO)
enniatin  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
ethyl methanesulfonate  (EXP)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP)
fenoldopam  (ISO)
flavonoids  (ISO)
formaldehyde  (EXP)
fumonisin B1  (ISO)
furan  (ISO)
furosemide  (ISO)
Fusarenone X  (ISO)
gadolinium trichloride  (ISO)
gemcitabine  (EXP)
genistein  (EXP,ISO)
gingerol  (EXP)
glucose  (EXP)
Glutathione ethyl ester  (EXP)
glycochenodeoxycholic acid  (EXP)
glycocholic acid  (EXP)
glycodeoxycholic acid  (EXP)
glyphosate  (EXP)
Ilimaquinone  (EXP)
indometacin  (EXP)
irinotecan  (EXP)
iron atom  (EXP)
iron(0)  (EXP)
isoflurane  (ISO)
isoprenaline  (ISO)
isotretinoin  (EXP)
ketoconazole  (EXP)
kojic acid  (ISO)
L-ascorbic acid  (EXP)
Lasiocarpine  (EXP)
lead diacetate  (EXP,ISO)
leflunomide  (EXP)
lipoic acid  (ISO)
lipopolysaccharide  (ISO)
lovastatin  (EXP)
luteolin  (EXP)
LY294002  (EXP)
masoprocol  (EXP)
mercury atom  (EXP)
mercury(0)  (EXP)
methotrexate  (EXP)
methyl methanesulfonate  (EXP)
methyltestosterone  (EXP)
mifepristone  (EXP)
mithramycin  (EXP)
mitomycin C  (EXP)
monocrotaline  (ISO)
morphine  (ISO)
Myrtucommulone A  (ISO)
N,N-dimethylformamide  (EXP)
N-(2-aminoethyl)-5-chloroisoquinoline-8-sulfonamide  (EXP)
N-acetyl-L-cysteine  (EXP)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (EXP)
naproxen  (ISO)
nefazodone  (EXP)
nickel atom  (EXP)
nickel dichloride  (EXP)
nickel sulfate  (EXP)
NS-398  (EXP)
okadaic acid  (EXP)
olaparib  (EXP)
orlistat  (EXP)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
p-menthan-3-ol  (EXP)
paclitaxel  (EXP)
Panduratin A  (EXP)
panobinostat  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
Pentoxifylline  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP,ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
poly(I:C)  (ISO)
potassium chromate  (EXP)
potassium dichromate  (EXP)
progesterone  (EXP)
propylparaben  (EXP)
Protolichesterinic acid  (EXP)
quartz  (EXP)
quercetin  (EXP)
quinolin-8-ol  (EXP)
rac-lactic acid  (EXP)
reactive nitrogen species  (EXP)
reactive oxygen species  (EXP)
rebaudioside A  (EXP)
reserpine  (ISO)
resveratrol  (EXP)
ribavirin  (EXP)
riddelliine  (ISO)
rifampicin  (ISO)
Ro 31-8220  (EXP)
rotenone  (ISO)
sanguinarine  (EXP)
SB 203580  (EXP)
Se-methyl-L-selenocysteine  (EXP)
Se-methylselenocysteine  (EXP)
selenium atom  (EXP)
serpentine asbestos  (EXP)
silicon dioxide  (EXP)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (EXP)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium dodecyl sulfate  (EXP)
sorafenib  (EXP)
steviol  (EXP)
stevioside  (EXP)
styrene  (EXP)
succimer  (EXP)
sulforaphane  (EXP)
sulindac  (EXP)
sulindac sulfide  (EXP)
sumatriptan  (ISO)
Sunset Yellow FCF  (EXP)
tamibarotene  (EXP)
tamoxifen  (EXP)
tanespimycin  (EXP)
Tanshinone I  (EXP)
tartrazine  (EXP)
temozolomide  (EXP)
tert-butyl hydroperoxide  (EXP)
testosterone  (ISO)
testosterone enanthate  (EXP)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thalidomide  (EXP)
thioacetamide  (ISO)
thiophenes  (EXP)
titanium dioxide  (ISO)
tofacitinib  (EXP)
tranilast  (ISO)
Triptolide  (ISO)
troglitazone  (EXP)
tungsten  (ISO)
tunicamycin  (ISO)
urethane  (EXP)
valproic acid  (EXP)
venom  (EXP)
vinclozolin  (ISO)
vincristine  (EXP)
vitamin D  (EXP)
vitamin E  (EXP)
vorinostat  (EXP)
Y-27632  (EXP)
zearalenone  (EXP)
zidovudine  (EXP)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Chen B, etal., Zhonghua Yi Xue Za Zhi. 2008 Feb 26;88(8):540-5.
2. Dirice E, etal., Hum Gene Ther. 2009 Aug 21.
3. Falschlehner C, etal., Int J Biochem Cell Biol. 2007;39(7-8):1462-75. Epub 2007 Feb 14.
4. GOA_HUMAN data from the GO Consortium
5. Lamhamedi-Cherradi SE, etal., Nat Immunol. 2003 Mar;4(3):255-60. Epub 2003 Feb 10.
6. Lee SW, etal., Arthritis Rheum. 2004 Feb;50(2):534-42.
7. Lorz C, etal., J Am Soc Nephrol. 2008 May;19(5):904-14. Epub 2008 Feb 20.
8. Mi QS, etal., Diabetes. 2003 Aug;52(8):1967-75.
9. Pennarun B, etal., Biochim Biophys Acta. 2010 Apr;1805(2):123-40. Epub 2009 Dec 2.
10. Pipeline to import KEGG annotations from KEGG into RGD
11. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. RGD automated import pipeline for gene-chemical interactions
14. Salehi E, etal., Iran J Immunol. 2007 Dec;4(4):197-205.
15. Secchiero P, etal., Circulation. 2006 Oct 3;114(14):1522-30. Epub 2006 Sep 25.
16. Tang X, etal., Life Sci. 2009 Apr 10;84(15-16):552-7.
17. Tang YM, etal., Zhonghua Yi Xue Za Zhi. 2005 Aug 3;85(29):2021-5.
18. Xiong Y, etal., Emerg Microbes Infect. 2020 Dec;9(1):761-770. doi: 10.1080/22221751.2020.1747363.
19. Zhang J, etal., J Huazhong Univ Sci Technolog Med Sci. 2007 Jun;27(3):311-4.
20. Zhou Z, etal., Cell Host Microbe. 2020 Jun 10;27(6):883-890.e2. doi: 10.1016/j.chom.2020.04.017. Epub 2020 May 4.
Additional References at PubMed
PMID:8663110   PMID:8777713   PMID:8793301   PMID:9082980   PMID:9242610   PMID:9311998   PMID:9314565   PMID:9325248   PMID:9430226   PMID:9520411   PMID:9613612   PMID:9754559  
PMID:9830064   PMID:10485660   PMID:10542098   PMID:10549288   PMID:10651627   PMID:10894160   PMID:10960444   PMID:11022932   PMID:11027498   PMID:11059770   PMID:11094155   PMID:11095979  
PMID:11243698   PMID:11385301   PMID:11466352   PMID:11553609   PMID:11568006   PMID:11677236   PMID:11739488   PMID:11781716   PMID:11830480   PMID:11844843   PMID:11852102   PMID:11877293  
PMID:11936954   PMID:11940602   PMID:11956660   PMID:11964312   PMID:11994437   PMID:12029096   PMID:12036888   PMID:12082620   PMID:12082629   PMID:12097384   PMID:12097388   PMID:12118245  
PMID:12140294   PMID:12198154   PMID:12221720   PMID:12351634   PMID:12359235   PMID:12398939   PMID:12407100   PMID:12414956   PMID:12421926   PMID:12421985   PMID:12421989   PMID:12429913  
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PMID:15615731   PMID:15619633   PMID:15634757   PMID:15637055   PMID:15653751   PMID:15655781   PMID:15671071   PMID:15681838   PMID:15688023   PMID:15757891   PMID:15760909   PMID:15767553  
PMID:15774464   PMID:15792357   PMID:15806163   PMID:15809718   PMID:15828026   PMID:15884050   PMID:15887227   PMID:15916713   PMID:15962328   PMID:15990565   PMID:15996036   PMID:16007425  
PMID:16026644   PMID:16037944   PMID:16040132   PMID:16041267   PMID:16046522   PMID:16082383   PMID:16116625   PMID:16166346   PMID:16169070   PMID:16174727   PMID:16178278   PMID:16180223  
PMID:16199534   PMID:16206163   PMID:16215673   PMID:16226105   PMID:16229016   PMID:16245299   PMID:16288714   PMID:16289694   PMID:16344560   PMID:16368536   PMID:16382051   PMID:16436464  
PMID:16449964   PMID:16455983   PMID:16459719   PMID:16478725   PMID:16514644   PMID:16518756   PMID:16554480   PMID:16574768   PMID:16607283   PMID:16627981   PMID:16645643   PMID:16731632  
PMID:16751802   PMID:16785986   PMID:16807984   PMID:16820090   PMID:16831934   PMID:16857810   PMID:16863850   PMID:16887991   PMID:16941746   PMID:16950202   PMID:16951203   PMID:17012835  
PMID:17070520   PMID:17079165   PMID:17110373   PMID:17187253   PMID:17195089   PMID:17278883   PMID:17314102   PMID:17352408   PMID:17356300   PMID:17384675   PMID:17420249   PMID:17431115  
PMID:17431792   PMID:17479107   PMID:17495957   PMID:17513605   PMID:17525260   PMID:17540725   PMID:17544413   PMID:17548900   PMID:17553352   PMID:17554866   PMID:17558561   PMID:17571163  
PMID:17579120   PMID:17583676   PMID:17617740   PMID:17638906   PMID:17683987   PMID:17686764   PMID:17697742   PMID:17701086   PMID:17702740   PMID:17703232   PMID:17765202   PMID:17767167  
PMID:17803681   PMID:17881904   PMID:17884184   PMID:17895594   PMID:17900262   PMID:17907960   PMID:17913827   PMID:17932312   PMID:17938258   PMID:17940338   PMID:17947462   PMID:17956986  
PMID:17982483   PMID:17983809   PMID:18006822   PMID:18006832   PMID:18006836   PMID:18031928   PMID:18063697   PMID:18089811   PMID:18174230   PMID:18178561   PMID:18187663   PMID:18202704  
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PMID:18348311   PMID:18362888   PMID:18362891   PMID:18375389   PMID:18385934   PMID:18413764   PMID:18424742   PMID:18430896   PMID:18451172   PMID:18474604   PMID:18483205   PMID:18491232  
PMID:18502726   PMID:18519235   PMID:18522940   PMID:18566412   PMID:18599181   PMID:18599488   PMID:18640940   PMID:18644981   PMID:18723061   PMID:18726983   PMID:18772312   PMID:18780288  
PMID:18802096   PMID:18814951   PMID:18834856   PMID:18838202   PMID:18922903   PMID:18942021   PMID:19050264   PMID:19058836   PMID:19074436   PMID:19074831   PMID:19106633   PMID:19147771  
PMID:19197243   PMID:19199708   PMID:19203346   PMID:19212626   PMID:19221598   PMID:19223770   PMID:19236007   PMID:19261616   PMID:19265041   PMID:19270498   PMID:19281785   PMID:19289465  
PMID:19294332   PMID:19305384   PMID:19309556   PMID:19349211   PMID:19361506   PMID:19379558   PMID:19385057   PMID:19398149   PMID:19404407   PMID:19406930   PMID:19407827   PMID:19412666  
PMID:19418484   PMID:19427028   PMID:19432816   PMID:19435900   PMID:19449143   PMID:19453261   PMID:19470406   PMID:19476940   PMID:19481529   PMID:19519609   PMID:19533303   PMID:19540229  
PMID:19573080   PMID:19587531   PMID:19597472   PMID:19629467   PMID:19632771   PMID:19671825   PMID:19674787   PMID:19690337   PMID:19724854   PMID:19749795   PMID:19767219   PMID:19773279  
PMID:19782681   PMID:19802013   PMID:19812265   PMID:19854352   PMID:19890662   PMID:19896469   PMID:19948942   PMID:19954364   PMID:19954896   PMID:19956887   PMID:19962668   PMID:19962958  
PMID:19967427   PMID:20007807   PMID:20042498   PMID:20097879   PMID:20103630   PMID:20119620   PMID:20123409   PMID:20150555   PMID:20189551   PMID:20204286   PMID:20237496   PMID:20308427  
PMID:20334827   PMID:20339295   PMID:20354842   PMID:20372797   PMID:20379197   PMID:20393185   PMID:20394499   PMID:20400979   PMID:20417200   PMID:20424169   PMID:20430391   PMID:20443055  
PMID:20560677   PMID:20568250   PMID:20580220   PMID:20580868   PMID:20628624   PMID:20638129   PMID:20638385   PMID:20671119   PMID:20734142   PMID:20802294   PMID:20811726   PMID:20819778  
PMID:20838376   PMID:20839416   PMID:20852190   PMID:20862322   PMID:20961336   PMID:20977779   PMID:21047948   PMID:21059290   PMID:21064084   PMID:21086019   PMID:21107885   PMID:21120579  
PMID:21125311   PMID:21160038   PMID:21167276   PMID:21183948   PMID:21209944   PMID:21211989   PMID:21248767   PMID:21255088   PMID:21279373   PMID:21291526   PMID:21305500   PMID:21308719  
PMID:21317160   PMID:21368892   PMID:21381010   PMID:21426505   PMID:21435442   PMID:21437625   PMID:21437722   PMID:21454681   PMID:21459798   PMID:21465464   PMID:21480222   PMID:21482133  
PMID:21483669   PMID:21485546   PMID:21525012   PMID:21525171   PMID:21538027   PMID:21554547   PMID:21603612   PMID:21622121   PMID:21670755   PMID:21695716   PMID:21697087   PMID:21706325  
PMID:21732015   PMID:21760914   PMID:21769428   PMID:21769834   PMID:21802664   PMID:21822306   PMID:21824395   PMID:21846721   PMID:21859711   PMID:21864851   PMID:21873635   PMID:21926463  
PMID:21941373   PMID:21952139   PMID:21988644   PMID:21993926   PMID:22023762   PMID:22034880   PMID:22072062   PMID:22110611   PMID:22159760   PMID:22194780   PMID:22202560   PMID:22266862  
PMID:22310286   PMID:22320196   PMID:22322844   PMID:22328338   PMID:22345097   PMID:22354145   PMID:22384114   PMID:22392486   PMID:22398750   PMID:22408249   PMID:22449797   PMID:22462553  
PMID:22471587   PMID:22496450   PMID:22528215   PMID:22542907   PMID:22554587   PMID:22585859   PMID:22698523   PMID:22719861   PMID:22729471   PMID:22783581   PMID:22883061   PMID:22898820  
PMID:22899350   PMID:22914768   PMID:22922789   PMID:22942757   PMID:22948392   PMID:23014529   PMID:23018355   PMID:23053497   PMID:23071256   PMID:23085529   PMID:23096115   PMID:23142077  
PMID:23228130   PMID:23247197   PMID:23258590   PMID:23277172   PMID:23290504   PMID:23306613   PMID:23319802   PMID:23333304   PMID:23375756   PMID:23384657   PMID:23392805   PMID:23408429  
PMID:23426404   PMID:23428290   PMID:23437333   PMID:23441146   PMID:23456625   PMID:23457619   PMID:23468057   PMID:23472162   PMID:23481489   PMID:23492758   PMID:23492767   PMID:23535064  
PMID:23579274   PMID:23615398   PMID:23636231   PMID:23667901   PMID:23674352   PMID:23678861   PMID:23686163   PMID:23688319   PMID:23699397   PMID:23699656   PMID:23703388   PMID:23722000  
PMID:23732517   PMID:23774624   PMID:23792015   PMID:23822995   PMID:23857473   PMID:23931066   PMID:23932896   PMID:23937794   PMID:23944369   PMID:23959437   PMID:23974204   PMID:23981753  
PMID:23986130   PMID:24001901   PMID:24002210   PMID:24019170   PMID:24040204   PMID:24065684   PMID:24078627   PMID:24083751   PMID:24097299   PMID:24100030   PMID:24145180   PMID:24148916  
PMID:24155891   PMID:24167941   PMID:24184557   PMID:24194568   PMID:24204567   PMID:24213373   PMID:24223304   PMID:24272336   PMID:24272484   PMID:24277417   PMID:24280212   PMID:24287696  
PMID:24299309   PMID:24344047   PMID:24349222   PMID:24390815   PMID:24431076   PMID:24438025   PMID:24446659   PMID:24447304   PMID:24466325   PMID:24481457   PMID:24488010   PMID:24507727  
PMID:24525736   PMID:24551275   PMID:24556678   PMID:24603337   PMID:24633224   PMID:24660552   PMID:24667918   PMID:24675460   PMID:24690311   PMID:24705354   PMID:24736722   PMID:24742347  
PMID:24788726   PMID:24825910   PMID:24840271   PMID:24866247   PMID:24905916   PMID:24909691   PMID:24913933   PMID:24939851   PMID:24946096   PMID:24966465   PMID:25001536   PMID:25043307  
PMID:25085377   PMID:25113506   PMID:25123818   PMID:25170834   PMID:25173558   PMID:25174275   PMID:25279491   PMID:25293521   PMID:25294014   PMID:25351208   PMID:25445452   PMID:25445592  
PMID:25522273   PMID:25551360   PMID:25562155   PMID:25572524   PMID:25584433   PMID:25586349   PMID:25605161   PMID:25607248   PMID:25636966   PMID:25647515   PMID:25683371   PMID:25684021  
PMID:25684663   PMID:25712717   PMID:25720720   PMID:25760768   PMID:25778329   PMID:25779046   PMID:25813908   PMID:25827060   PMID:25833292   PMID:25834817   PMID:25843953   PMID:25845236  
PMID:25852190   PMID:25857555   PMID:25882551   PMID:25894375   PMID:25925126   PMID:25955868   PMID:25962125   PMID:25974396   PMID:25981737   PMID:26050621   PMID:26063410   PMID:26078955  
PMID:26083528   PMID:26086178   PMID:26098775   PMID:26116899   PMID:26124099   PMID:26134947   PMID:26142735   PMID:26165401   PMID:26220665   PMID:26245704   PMID:26247836   PMID:26254281  
PMID:26259382   PMID:26261530   PMID:26261645   PMID:26304927   PMID:26314314   PMID:26320191   PMID:26334877   PMID:26381901   PMID:26457518   PMID:26504794   PMID:26506422   PMID:26518902  
PMID:26555706   PMID:26563749   PMID:26572549   PMID:26577955   PMID:26609227   PMID:26615420   PMID:26633016   PMID:26646413   PMID:26648023   PMID:26698404   PMID:26708508   PMID:26718429  
PMID:26720004   PMID:26721202   PMID:26733169   PMID:26792723   PMID:26802603   PMID:26841509   PMID:26871575   PMID:26878683   PMID:26924459   PMID:26935795   PMID:26944067   PMID:26962689  
PMID:26964637   PMID:26982083   PMID:27067438   PMID:27128817   PMID:27176505   PMID:27210546   PMID:27260301   PMID:27277541   PMID:27353001   PMID:27358484   PMID:27403809   PMID:27461934  
PMID:27466296   PMID:27472871   PMID:27580702   PMID:27612013   PMID:27618431   PMID:27692344   PMID:27721019   PMID:27725224   PMID:27735943   PMID:27740879   PMID:27750195   PMID:27763797  
PMID:27780136   PMID:27821809   PMID:27849590   PMID:27878298   PMID:27918462   PMID:28002586   PMID:28025428   PMID:28039489   PMID:28049841   PMID:28075429   PMID:28120533   PMID:28154184  
PMID:28212752   PMID:28212753   PMID:28270124   PMID:28270653   PMID:28281970   PMID:28324269   PMID:28337703   PMID:28378099   PMID:28391262   PMID:28409399   PMID:28424227   PMID:28429751  
PMID:28440502   PMID:28455246   PMID:28476883   PMID:28498435   PMID:28507343   PMID:28524007   PMID:28551332   PMID:28587866   PMID:28631177   PMID:28639887   PMID:28659589   PMID:28694499  
PMID:28718726   PMID:28827731   PMID:28925481   PMID:28972304   PMID:28975649   PMID:28981092   PMID:29039600   PMID:29048428   PMID:29055676   PMID:29145460   PMID:29158840   PMID:29182622  
PMID:29247155   PMID:29284457   PMID:29345617   PMID:29432906   PMID:29434187   PMID:29533922   PMID:29638207   PMID:29652777   PMID:29661248   PMID:29674187   PMID:29699990   PMID:29721092  
PMID:29739045   PMID:29741767   PMID:29777390   PMID:29927992   PMID:29999450   PMID:30051596   PMID:30061204   PMID:30061216   PMID:30183357   PMID:30268671   PMID:30305380   PMID:30361617  
PMID:30385739   PMID:30431076   PMID:30481147   PMID:30589515   PMID:30592139   PMID:30612454   PMID:30621488   PMID:30645753   PMID:30647121   PMID:30692634   PMID:30732588   PMID:30748035  
PMID:30782845   PMID:30862357   PMID:30947287   PMID:31030944   PMID:31056533   PMID:31097613   PMID:31114586   PMID:31149947   PMID:31189571   PMID:31433987   PMID:31547718   PMID:31553694  
PMID:31629739   PMID:31673231   PMID:31676378   PMID:31744505   PMID:31828111   PMID:31894259   PMID:31896813   PMID:32020226   PMID:32210394   PMID:32210710   PMID:32260540   PMID:32327638  
PMID:32342239   PMID:32406872   PMID:32485960   PMID:32636833   PMID:32645396   PMID:32669373   PMID:32722598   PMID:32732304   PMID:32759789   PMID:32777260   PMID:32958259   PMID:32988888  
PMID:33050112   PMID:33108704   PMID:33203916   PMID:33215853   PMID:33408417   PMID:33754061   PMID:33770100   PMID:33806288   PMID:33942150   PMID:33961781   PMID:34080646   PMID:34099729  
PMID:34167551   PMID:34174975   PMID:34282054   PMID:34342264   PMID:34356656   PMID:34546352   PMID:34584171   PMID:34728311  


Genomics

Comparative Map Data
TNFSF10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3172,505,508 - 172,523,475 (-)EnsemblGRCh38hg38GRCh38
GRCh383172,505,508 - 172,523,430 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373172,223,298 - 172,241,220 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363173,706,158 - 173,723,963 (-)NCBINCBI36hg18NCBI36
Build 343173,706,166 - 173,723,971NCBI
Celera3170,621,889 - 170,639,888 (-)NCBI
Cytogenetic Map3q26.31NCBI
HuRef3169,593,908 - 169,611,904 (-)NCBIHuRef
CHM1_13172,186,184 - 172,204,170 (-)NCBICHM1_1
Tnfsf10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39327,371,226 - 27,393,814 (+)NCBIGRCm39mm39
GRCm39 Ensembl327,371,177 - 27,396,576 (+)Ensembl
GRCm38327,317,077 - 27,339,665 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl327,317,028 - 27,342,427 (+)EnsemblGRCm38mm10GRCm38
MGSCv37327,215,999 - 27,238,587 (+)NCBIGRCm37mm9NCBIm37
MGSCv36327,508,150 - 27,530,738 (+)NCBImm8
Celera327,279,765 - 27,300,536 (+)NCBICelera
Cytogenetic Map3A3NCBI
Tnfsf10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22110,199,835 - 110,227,239 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl2110,207,916 - 110,225,135 (+)Ensembl
Rnor_6.02113,008,008 - 113,026,899 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2113,007,549 - 113,026,899 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02132,726,333 - 132,742,550 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42113,204,303 - 113,221,550 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12113,149,265 - 113,166,510 (+)NCBI
Celera2105,412,626 - 105,429,375 (+)NCBICelera
Cytogenetic Map2q24NCBI
Tnfsf10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554202,549,142 - 2,566,564 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554202,550,392 - 2,566,448 (-)NCBIChiLan1.0ChiLan1.0
TNFSF10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13177,693,860 - 177,712,137 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3177,694,021 - 177,712,137 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03169,512,491 - 169,530,706 (-)NCBIMhudiblu_PPA_v0panPan3
TNFSF10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13436,719,249 - 36,734,989 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3436,670,849 - 36,735,060 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3445,731,787 - 45,747,520 (-)NCBI
ROS_Cfam_1.03436,803,929 - 36,819,723 (-)NCBI
ROS_Cfam_1.0 Ensembl3436,802,389 - 36,820,029 (-)Ensembl
UMICH_Zoey_3.13436,742,701 - 36,758,427 (-)NCBI
UNSW_CanFamBas_1.03436,711,390 - 36,727,143 (-)NCBI
UU_Cfam_GSD_1.03436,969,308 - 36,985,009 (-)NCBI
Tnfsf10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602103,391,320 - 103,422,437 (-)NCBI
SpeTri2.0NW_004936593212,642 - 230,645 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNFSF10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13110,981,604 - 111,107,423 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113111,021,952 - 111,103,060 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213119,874,763 - 119,882,251 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TNFSF10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11516,934,982 - 16,953,155 (+)NCBIChlSab1.1chlSab2
ChlSab1.11516,934,982 - 16,953,155 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1516,934,962 - 16,954,860 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606325,697,846 - 25,715,823 (+)NCBIVero_WHO_p1.0
Tnfsf10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473050,534,284 - 50,550,279 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
TNFSF10_266  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373172,223,452 - 172,224,120UniSTSGRCh37
Build 363173,706,146 - 173,706,814RGDNCBI36
Celera3170,622,043 - 170,622,710RGD
HuRef3169,594,062 - 169,594,730UniSTS
SHGC-77549  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373172,224,280 - 172,224,401UniSTSGRCh37
Build 363173,706,974 - 173,707,095RGDNCBI36
Celera3170,622,870 - 170,622,991RGD
Cytogenetic Map3q26UniSTS
HuRef3169,594,890 - 169,595,011UniSTS
TNG Radiation Hybrid Map337771.0UniSTS
GeneMap99-GB4 RH Map3645.51UniSTS
NCBI RH Map31550.6UniSTS
RH66570  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373172,223,574 - 172,223,740UniSTSGRCh37
Build 363173,706,268 - 173,706,434RGDNCBI36
Celera3170,622,164 - 170,622,330RGD
Cytogenetic Map3q26UniSTS
HuRef3169,594,184 - 169,594,350UniSTS
GeneMap99-GB4 RH Map3643.31UniSTS
NCBI RH Map31550.6UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR222hsa-miR-222-3pMirtarbaseexternal_infoWestern blotFunctional MTI18246122
MIR221hsa-miR-221-3pMirtarbaseexternal_infoWestern blotFunctional MTI18246122

Predicted Target Of
Summary Value
Count of predictions:1282
Count of miRNA genes:718
Interacting mature miRNAs:809
Transcripts:ENST00000241261, ENST00000420541, ENST00000430881, ENST00000466777, ENST00000472804, ENST00000494851
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 3 24 12
Medium 2297 2105 1534 570 1542 408 3401 1406 1253 379 988 1414 173 1 1198 2114 4 2
Low 119 886 184 52 390 54 712 753 2429 33 423 94 1 6 674 2
Below cutoff 13 6 2 16 3 179 13 24 20 57 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001190942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001190943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_003810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_033994 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC007919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC016938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF178756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK296085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK309200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY312579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC009795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC020220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC032722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT019564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CQ892411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR456895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS276168 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA041872 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA969653 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ848564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EF064708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU183231 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HA637646 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JA362607 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT258720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  LN874323 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U37518 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U57059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000241261   ⟹   ENSP00000241261
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3172,505,508 - 172,523,430 (-)Ensembl
RefSeq Acc Id: ENST00000420541   ⟹   ENSP00000389931
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3172,505,662 - 172,523,475 (-)Ensembl
RefSeq Acc Id: ENST00000430881   ⟹   ENSP00000404008
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3172,507,284 - 172,523,310 (-)Ensembl
RefSeq Acc Id: ENST00000466777
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3172,517,355 - 172,523,467 (-)Ensembl
RefSeq Acc Id: ENST00000472804
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3172,511,445 - 172,523,465 (-)Ensembl
RefSeq Acc Id: ENST00000494851
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3172,509,146 - 172,523,467 (-)Ensembl
RefSeq Acc Id: NM_001190942   ⟹   NP_001177871
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383172,505,508 - 172,523,430 (-)NCBI
GRCh373172,223,298 - 172,241,297 (-)ENTREZGENE
HuRef3169,593,908 - 169,611,904 (-)ENTREZGENE
CHM1_13172,186,184 - 172,204,170 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001190943   ⟹   NP_001177872
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383172,517,355 - 172,523,430 (-)NCBI
GRCh373172,223,298 - 172,241,297 (-)ENTREZGENE
HuRef3169,593,908 - 169,611,904 (-)ENTREZGENE
CHM1_13172,198,023 - 172,204,138 (-)NCBI
Sequence:
RefSeq Acc Id: NM_003810   ⟹   NP_003801
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383172,505,508 - 172,523,430 (-)NCBI
GRCh373172,223,298 - 172,241,297 (-)ENTREZGENE
Build 363173,706,158 - 173,723,963 (-)NCBI Archive
HuRef3169,593,908 - 169,611,904 (-)ENTREZGENE
CHM1_13172,186,184 - 172,204,170 (-)NCBI
Sequence:
RefSeq Acc Id: NR_033994
RefSeq Status: REVIEWED
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383172,505,508 - 172,523,430 (-)NCBI
GRCh373172,223,298 - 172,241,297 (-)ENTREZGENE
HuRef3169,593,908 - 169,611,904 (-)ENTREZGENE
CHM1_13172,186,184 - 172,204,170 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001177871   ⟸   NM_001190942
- Peptide Label: isoform 2
- UniProtKB: P50591 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_003801   ⟸   NM_003810
- Peptide Label: isoform 1
- UniProtKB: P50591 (UniProtKB/Swiss-Prot),   Q6IBA9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001177872   ⟸   NM_001190943
- Peptide Label: isoform 3
- Sequence:
RefSeq Acc Id: ENSP00000241261   ⟸   ENST00000241261
RefSeq Acc Id: ENSP00000404008   ⟸   ENST00000430881
RefSeq Acc Id: ENSP00000389931   ⟸   ENST00000420541
Protein Domains
TNF_2

Promoters
RGD ID:6866292
Promoter ID:EPDNEW_H6311
Type:initiation region
Name:TNFSF10_1
Description:TNF superfamily member 10
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh383172,523,467 - 172,523,527EPDNEW
RGD ID:6801805
Promoter ID:HG_KWN:46729
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000382750,   OTTHUMT00000346601,   OTTHUMT00000346603,   OTTHUMT00000346605,   OTTHUMT00000346606,   OTTHUMT00000346607,   UC003FIE.1,   UC010HWU.1
Position:
Human AssemblyChrPosition (strand)Source
Build 363173,723,634 - 173,724,134 (-)MPROMDB
RGD ID:6853512
Promoter ID:EP74583
Type:initiation region
Name:HS_TNFSF10
Description:Tumor necrosis factor (ligand) superfamily, member 10.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Mammalian gene collection (MGC) full-length cDNA cloning
Position:
Human AssemblyChrPosition (strand)Source
Build 363173,723,922 - 173,723,982EPD

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 3q24-26.32(chr3:147442566-178522531)x3 copy number gain See cases [RCV000051724] Chr3:147442566..178522531 [GRCh38]
Chr3:147160353..178240319 [GRCh37]
Chr3:148643043..179723013 [NCBI36]
Chr3:3q24-26.32
pathogenic
GRCh38/hg38 3q24-29(chr3:147521892-198096565)x3 copy number gain See cases [RCV000051725] Chr3:147521892..198096565 [GRCh38]
Chr3:147239679..197823436 [GRCh37]
Chr3:148722369..199307833 [NCBI36]
Chr3:3q24-29
pathogenic
GRCh38/hg38 3q25.31-29(chr3:157293378-198134727)x3 copy number gain See cases [RCV000051726] Chr3:157293378..198134727 [GRCh38]
Chr3:157011167..197861598 [GRCh37]
Chr3:158493861..199345995 [NCBI36]
Chr3:3q25.31-29
pathogenic
GRCh38/hg38 3q25.32-26.31(chr3:158141556-172788324)x3 copy number gain See cases [RCV000051735] Chr3:158141556..172788324 [GRCh38]
Chr3:157859345..172506114 [GRCh37]
Chr3:159342039..173988808 [NCBI36]
Chr3:3q25.32-26.31
pathogenic
GRCh38/hg38 3q22.3-29(chr3:137126982-198110178)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051723]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051723]|See cases [RCV000051723] Chr3:137126982..198110178 [GRCh38]
Chr3:136845824..197837049 [GRCh37]
Chr3:138328514..199321446 [NCBI36]
Chr3:3q22.3-29
pathogenic
NM_003810.3(TNFSF10):c.754G>A (p.Glu252Lys) single nucleotide variant Malignant melanoma [RCV000060768] Chr3:172506584 [GRCh38]
Chr3:172224374 [GRCh37]
Chr3:173707068 [NCBI36]
Chr3:3q26.31
not provided
NM_003810.3(TNFSF10):c.592G>A (p.Glu198Lys) single nucleotide variant Malignant melanoma [RCV000060769] Chr3:172506746 [GRCh38]
Chr3:172224536 [GRCh37]
Chr3:173707230 [NCBI36]
Chr3:3q26.31
not provided
NM_003810.3(TNFSF10):c.587T>A (p.Ile196Lys) single nucleotide variant Malignant melanoma [RCV000060770] Chr3:172506751 [GRCh38]
Chr3:172224541 [GRCh37]
Chr3:173707235 [NCBI36]
Chr3:3q26.31
not provided
GRCh38/hg38 3q13.11-29(chr3:103426882-198110178)x3 copy number gain See cases [RCV000134948] Chr3:103426882..198110178 [GRCh38]
Chr3:103145726..197837049 [GRCh37]
Chr3:104628416..199321446 [NCBI36]
Chr3:3q13.11-29
pathogenic
GRCh38/hg38 3q26.2-29(chr3:168167568-198110178)x3 copy number gain See cases [RCV000137106] Chr3:168167568..198110178 [GRCh38]
Chr3:167885356..197837049 [GRCh37]
Chr3:169368050..199321446 [NCBI36]
Chr3:3q26.2-29
pathogenic
GRCh38/hg38 3q26.31(chr3:172511598-172523485)x1 copy number loss See cases [RCV000136873] Chr3:172511598..172523485 [GRCh38]
Chr3:172229388..172241275 [GRCh37]
Chr3:173712082..173723969 [NCBI36]
Chr3:3q26.31
benign
GRCh38/hg38 3q26.1-26.33(chr3:165158611-180130168)x3 copy number gain See cases [RCV000139359] Chr3:165158611..180130168 [GRCh38]
Chr3:164876399..179847956 [GRCh37]
Chr3:166359093..181330650 [NCBI36]
Chr3:3q26.1-26.33
pathogenic
GRCh38/hg38 3q25.1-29(chr3:152100512-198118383)x3 copy number gain See cases [RCV000139435] Chr3:152100512..198118383 [GRCh38]
Chr3:151818301..197845254 [GRCh37]
Chr3:153300991..199329651 [NCBI36]
Chr3:3q25.1-29
pathogenic
GRCh38/hg38 3q25.31-29(chr3:156321878-198113452)x3 copy number gain See cases [RCV000140849] Chr3:156321878..198113452 [GRCh38]
Chr3:156039667..197840323 [GRCh37]
Chr3:157522361..199324720 [NCBI36]
Chr3:3q25.31-29
pathogenic
GRCh38/hg38 3q25.31-29(chr3:156118441-198125115)x3 copy number gain See cases [RCV000142310] Chr3:156118441..198125115 [GRCh38]
Chr3:155836230..197851986 [GRCh37]
Chr3:157318924..199336383 [NCBI36]
Chr3:3q25.31-29
pathogenic
GRCh38/hg38 3q26.1-28(chr3:167717962-188365272)x3 copy number gain See cases [RCV000142107] Chr3:167717962..188365272 [GRCh38]
Chr3:167435750..188083060 [GRCh37]
Chr3:168918444..189565754 [NCBI36]
Chr3:3q26.1-28
likely pathogenic
GRCh38/hg38 3q26.31(chr3:171968610-173131280)x1 copy number loss See cases [RCV000142520] Chr3:171968610..173131280 [GRCh38]
Chr3:171686400..172849070 [GRCh37]
Chr3:173169094..174331764 [NCBI36]
Chr3:3q26.31
likely pathogenic|uncertain significance
GRCh38/hg38 3q26.1-29(chr3:166137209-198125115)x3 copy number gain See cases [RCV000143694] Chr3:166137209..198125115 [GRCh38]
Chr3:165854997..197851986 [GRCh37]
Chr3:167337691..199336383 [NCBI36]
Chr3:3q26.1-29
pathogenic
GRCh37/hg19 3q26.31(chr3:172003745-172520446)x3 copy number gain Ductal breast carcinoma [RCV000207159] Chr3:172003745..172520446 [GRCh37]
Chr3:3q26.31
uncertain significance
GRCh37/hg19 3q24-29(chr3:142995020-192997215)x4 copy number gain See cases [RCV000240256] Chr3:142995020..192997215 [GRCh37]
Chr3:3q24-29
pathogenic
GRCh37/hg19 3q25.32-29(chr3:158980631-197766890)x3 copy number gain See cases [RCV000447464] Chr3:158980631..197766890 [GRCh37]
Chr3:3q25.32-29
pathogenic
GRCh37/hg19 3q26.31(chr3:171852267-172413810)x3 copy number gain See cases [RCV000446103] Chr3:171852267..172413810 [GRCh37]
Chr3:3q26.31
uncertain significance
GRCh37/hg19 3q25.32-26.33(chr3:157128738-181637333)x3 copy number gain See cases [RCV000446611] Chr3:157128738..181637333 [GRCh37]
Chr3:3q25.32-26.33
pathogenic
GRCh37/hg19 3q25.2-29(chr3:152356847-197851986)x3 copy number gain See cases [RCV000448608] Chr3:152356847..197851986 [GRCh37]
Chr3:3q25.2-29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986)x3 copy number gain See cases [RCV000511055] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986) copy number gain See cases [RCV000512358] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61495-197838262)x3 copy number gain not provided [RCV000742138] Chr3:61495..197838262 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:60174-197948027)x3 copy number gain not provided [RCV000742133] Chr3:60174..197948027 [GRCh37]
Chr3:3p26.3-q29
pathogenic
NM_003810.4(TNFSF10):c.132+44A>C single nucleotide variant not provided [RCV001709229] Chr3:172523209 [GRCh38]
Chr3:172240999 [GRCh37]
Chr3:3q26.31
benign
NM_003810.4(TNFSF10):c.105C>T (p.Tyr35=) single nucleotide variant not provided [RCV000948663] Chr3:172523280 [GRCh38]
Chr3:172241070 [GRCh37]
Chr3:3q26.31
benign
NM_003810.4(TNFSF10):c.261C>T (p.Leu87=) single nucleotide variant not provided [RCV000937754] Chr3:172514870 [GRCh38]
Chr3:172232660 [GRCh37]
Chr3:3q26.31
likely benign
NM_003810.4(TNFSF10):c.97G>A (p.Val33Ile) single nucleotide variant not provided [RCV000971499] Chr3:172523288 [GRCh38]
Chr3:172241078 [GRCh37]
Chr3:3q26.31
benign
GRCh37/hg19 3q26.31(chr3:172095903-173254604)x3 copy number gain not provided [RCV000847729] Chr3:172095903..173254604 [GRCh37]
Chr3:3q26.31
uncertain significance
NM_003810.4(TNFSF10):c.133-3652A>C single nucleotide variant not provided [RCV001710558] Chr3:172518650 [GRCh38]
Chr3:172236440 [GRCh37]
Chr3:3q26.31
benign
NM_003810.4(TNFSF10):c.*207G>A single nucleotide variant not provided [RCV001637458] Chr3:172506285 [GRCh38]
Chr3:172224075 [GRCh37]
Chr3:3q26.31
benign
NM_003810.4(TNFSF10):c.314-88G>A single nucleotide variant not provided [RCV001527921] Chr3:172509409 [GRCh38]
Chr3:172227199 [GRCh37]
Chr3:3q26.31
benign
NM_003810.4(TNFSF10):c.825T>C (p.Phe275=) single nucleotide variant not provided [RCV001638201] Chr3:172506513 [GRCh38]
Chr3:172224303 [GRCh37]
Chr3:3q26.31
benign
GRCh37/hg19 3q26.2-28(chr3:169617690-190593854)x3 copy number gain not provided [RCV001005487] Chr3:169617690..190593854 [GRCh37]
Chr3:3q26.2-28
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:11925 AgrOrtholog
COSMIC TNFSF10 COSMIC
Ensembl Genes ENSG00000121858 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000241261 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000389931 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000404008 UniProtKB/TrEMBL
Ensembl Transcript ENST00000241261 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000420541 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000430881 UniProtKB/TrEMBL
  ENST00000466777 ENTREZGENE
Gene3D-CATH 2.60.120.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000121858 GTEx
HGNC ID HGNC:11925 ENTREZGENE
Human Proteome Map TNFSF10 Human Proteome Map
InterPro TNF_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNF_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNF_ligand_10/11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tumour_necrosis_fac-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:8743 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 8743 ENTREZGENE
OMIM 603598 OMIM
Pfam TNF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA36618 PharmGKB
PIRSF TNF10_TNF11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TNF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TNF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49842 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt H7C246_HUMAN UniProtKB/TrEMBL
  P50591 ENTREZGENE
  Q6IBA9 ENTREZGENE, UniProtKB/TrEMBL
  Q6JSD9_HUMAN UniProtKB/TrEMBL
  TNF10_HUMAN UniProtKB/Swiss-Prot
UniProt Secondary A1Y9B3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-03-07 TNFSF10  TNF superfamily member 10    tumor necrosis factor superfamily member 10  Symbol and/or name change 5135510 APPROVED
2015-11-24 TNFSF10  tumor necrosis factor superfamily member 10    tumor necrosis factor (ligand) superfamily, member 10  Symbol and/or name change 5135510 APPROVED