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Gene: HCN1 (hyperpolarization activated cyclic nucleotide gated potassium channel 1) Homo sapiens
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Symbol: HCN1
Name: hyperpolarization activated cyclic nucleotide gated potassium channel 1
Description: Exhibits cAMP binding activity; voltage-gated potassium channel activity; and voltage-gated sodium channel activity. Involved in several processes, including cellular response to cAMP; inorganic cation transmembrane transport; and protein homotetramerization. Localizes to HCN channel complex. Implicated in early infantile epileptic encephalopathy 24 and generalized epilepsy with febrile seizures plus 10. Biomarker of temporal lobe epilepsy.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: BCNG-1; BCNG1; brain cyclic nucleotide gated channel 1; brain cyclic nucleotide-gated channel 1; EIEE24; GEFSP10; HAC-2; hyperpolarization activated cyclic nucleotide-gated potassium channel 1; hyperpolarization-activated, cyclic nucleotide-gated potassium channel 1 (hcn1); potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl545,254,948 - 45,696,498 (-)EnsemblGRCh38hg38GRCh38
GRCh38545,254,948 - 45,696,380 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37545,255,052 - 45,696,220 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36545,295,109 - 45,731,977 (-)NCBINCBI36hg18NCBI36
Build 34545,297,729 - 45,731,977NCBI
Celera545,153,108 - 45,590,074 (-)NCBI
Cytogenetic Map5p12NCBI
HuRef545,207,222 - 45,649,517 (-)NCBIHuRef
CHM1_1545,254,898 - 45,696,071 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


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RNA-SEQ Expression

Sequence

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External Database Links
Nomenclature History
 
More on HCN1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733930
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.