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Gene: CXCR2 (C-X-C motif chemokine receptor 2) Homo sapiens
Symbol: CXCR2
Name: C-X-C motif chemokine receptor 2
Description: Exhibits interleukin-8 binding activity and interleukin-8 receptor activity. Involved in several processes, including interleukin-8-mediated signaling pathway; neutrophil activation; and neutrophil chemotaxis. Localizes to several cellular components, including cell surface; mast cell granule; and mitotic spindle. Implicated in IgA glomerulonephritis; acute pyelonephritis; end stage renal failure; and urinary bladder cancer. Biomarker of chronic obstructive pulmonary disease; nephroblastoma; and systemic lupus erythematosus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C-X-C chemokine receptor type 2; CD182; CDw128b; chemokine (C-X-C motif) receptor 2; chemokine (CXC) receptor 2; CMKAR2; CXC-R2; CXCR-2; CXCR2 gene for IL8 receptor type B; GRO/MGSA receptor; high affinity interleukin-8 receptor B; IL-8 receptor type 2; IL-8R B; IL8R2; IL8RA; IL8RB; interleukin 8 receptor B; interleukin 8 receptor type 2; interleukin 8 receptor, beta; interleukin-8 receptor type B
Mus musculus (house mouse) : Cxcr2 (chemokine (C-X-C motif) receptor 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cxcr2 (C-X-C motif chemokine receptor 2)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : CXCR2 (C-X-C motif chemokine receptor 2)
Canis lupus familiaris (dog) : CXCR2 (C-X-C motif chemokine receptor 2)
Sus scrofa (pig) : CXCR2 (C-X-C motif chemokine receptor 2)
Chlorocebus sabaeus (African green monkey) : CXCR2 (C-X-C motif chemokine receptor 2)
more info ...
Related Pseudogenes: CXCR2P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl2218,125,289 - 218,137,251 (+)EnsemblGRCh38hg38GRCh38
GRCh382218,125,294 - 218,137,253 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372218,990,013 - 219,001,976 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362218,698,991 - 218,710,220 (+)NCBINCBI36hg18NCBI36
Build 342218,816,251 - 218,827,481NCBI
Celera2212,756,449 - 212,768,411 (+)NCBI
Cytogenetic Map2q35NCBI
HuRef2210,842,767 - 210,854,732 (+)NCBIHuRef
CHM1_12218,996,503 - 219,008,469 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CXCR2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 735299
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-04-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.