CXCR2 (C-X-C motif chemokine receptor 2) - Rat Genome Database

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Gene: CXCR2 (C-X-C motif chemokine receptor 2) Homo sapiens
Analyze
Symbol: CXCR2
Name: C-X-C motif chemokine receptor 2
RGD ID: 735299
HGNC Page HGNC
Description: Exhibits interleukin-8 binding activity and interleukin-8 receptor activity. Involved in several processes, including cellular defense response; interleukin-8-mediated signaling pathway; and neutrophil chemotaxis. Localizes to several cellular components, including cell surface; mast cell granule; and mitotic spindle. Implicated in IgA glomerulonephritis; acute pyelonephritis; end stage renal disease; and urinary bladder cancer. Biomarker of chronic obstructive pulmonary disease; nephroblastoma; and systemic lupus erythematosus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C-X-C chemokine receptor type 2; CD182; CDw128b; chemokine (C-X-C motif) receptor 2; chemokine (CXC) receptor 2; CMKAR2; CXC-R2; CXCR-2; CXCR2 gene for IL8 receptor type B; GRO/MGSA receptor; high affinity interleukin-8 receptor B; IL-8 receptor type 2; IL-8R B; IL8R2; IL8RA; IL8RB; interleukin 8 receptor B; interleukin 8 receptor type 2; interleukin 8 receptor, beta; interleukin-8 receptor type B
RGD Orthologs
Mouse
Rat
Bonobo
Dog
Pig
Green Monkey
Alliance Genes
More Info more info ...
Related Pseudogenes: CXCR2P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2218,125,289 - 218,137,251 (+)EnsemblGRCh38hg38GRCh38
GRCh382218,125,294 - 218,137,253 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372218,990,017 - 219,001,974 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362218,698,991 - 218,710,220 (+)NCBINCBI36hg18NCBI36
Build 342218,816,251 - 218,827,481NCBI
Celera2212,756,449 - 212,768,411 (+)NCBI
Cytogenetic Map2q35NCBI
HuRef2210,842,767 - 210,854,732 (+)NCBIHuRef
CHM1_12218,996,503 - 219,008,469 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-nitropyrene  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-naphthylamine  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
aflatoxin B1  (EXP)
aminoguanidine  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (EXP)
arsenous acid  (EXP)
asperentin  (ISO)
atrazine  (EXP)
benzamide  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
carbon nanotube  (ISO)
celecoxib  (ISO)
ceric oxide  (ISO)
cisplatin  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
curcumin  (EXP)
cytochalasin D  (EXP)
Deoxycorticosterone acetate  (ISO)
deoxynivalenol  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP)
dichloroacetic acid  (EXP)
dichloromethane  (ISO)
doramapimod  (EXP)
dorsomorphin  (EXP)
ethyl methanesulfonate  (EXP)
ethylbenzene  (ISO)
excitatory amino acid agonist  (ISO)
fenvalerate  (ISO)
formaldehyde  (EXP)
furan  (ISO)
iron(2+) sulfate (anhydrous)  (EXP)
isoprenaline  (ISO)
lipoarabinomannan  (EXP)
lipopolysaccharide  (EXP)
lipoteichoic acid  (EXP)
mechlorethamine  (ISO)
methacholine chloride  (ISO)
methotrexate  (EXP)
methyl methanesulfonate  (EXP)
Monobutylphthalate  (ISO)
mycophenolic acid  (ISO)
mycotoxin  (ISO)
nickel atom  (EXP)
Nicotinamide N-oxide  (EXP)
nicotine  (EXP)
oleandrin  (EXP)
oxaliplatin  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (EXP)
paracetamol  (ISO)
phenobarbital  (ISO)
phorbol 13-acetate 12-myristate  (EXP)
potassium dichromate  (ISO)
prednisolone  (EXP)
SB 203580  (EXP)
SB 431542  (EXP)
silicon dioxide  (EXP,ISO)
simvastatin  (ISO)
sodium arsenite  (EXP)
sodium chloride  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thalidomide  (EXP)
thioacetamide  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
tributylstannane  (ISO)
trichloroethene  (ISO)
triclosan  (EXP)
tungsten  (ISO)
vinclozolin  (ISO)
wortmannin  (EXP)
XL147  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
1. Ajuebor MN, etal., Exp Mol Pathol. 2004 Feb;76(1):1-8.
2. Andrew AS, etal., Hum Genet. 2009 Jun;125(5-6):527-39. Epub 2009 Mar 1.
3. Bhatia M and Hegde A, Regul Pept. 2007 Jan 10;138(1):40-8. Epub 2006 Oct 2.
4. Brown CR, etal., J Immunol. 2003 Jul 15;171(2):893-901.
5. Cugini D, etal., Kidney Int. 2005 May;67(5):1753-61.
6. Eisele NA, etal., Am J Pathol. 2011 Mar;178(3):1190-200.
7. Eriksson C, etal., Lupus. 2003;12(10):766-74.
8. Fu WY, etal., Hepatol Res. 2013 Mar;43(3):300-10. doi: 10.1111/j.1872-034X.2012.01071.x. Epub 2012 Aug 6.
9. GOA_HUMAN data from the GO Consortium
10. Hoth JJ, etal., Shock. 2011 Jun;35(6):604-9.
11. Javor J, etal., Int J Immunogenet. 2012 Aug;39(4):338-45. doi: 10.1111/j.1744-313X.2012.01096.x. Epub 2012 Feb 10.
12. Kang MK, etal., Am J Physiol Renal Physiol. 2012 Oct;303(7):F1060-9. doi: 10.1152/ajprenal.00106.2012. Epub 2012 Jul 11.
13. Kerstetter AE, etal., Exp Neurol. 2009 Nov;220(1):44-56. doi: 10.1016/j.expneurol.2009.07.010. Epub 2009 Jul 17.
14. Levashova ZB, etal., J Am Soc Nephrol. 2007 Aug;18(8):2359-70. Epub 2007 Jul 18.
15. Li L, etal., J Clin Invest. 2010 Jan;120(1):331-42. doi: 10.1172/JCI38702. Epub 2009 Dec 14.
16. Marcos V, etal., Nat Med. 2010 Sep;16(9):1018-23. Epub 2010 Sep 5.
17. Marotta DM, etal., Biochem Pharmacol. 2009 Apr 1;77(7):1223-35.
18. Marques RE, etal., Immunology. 2018 Dec;155(4):477-490. doi: 10.1111/imm.12988. Epub 2018 Sep 10.
19. Martin-Manso G, etal., PLoS One. 2012;7(11):e48775. doi: 10.1371/journal.pone.0048775. Epub 2012 Nov 7.
20. Mestas J, etal., J Immunol. 2005 Oct 15;175(8):5351-7.
21. Nagarkar DR, etal., J Immunol. 2009 Nov 15;183(10):6698-707. Epub 2009 Oct 28.
22. Pipeline to import KEGG annotations from KEGG into RGD
23. Qiu Y, etal., Am J Respir Crit Care Med. 2003 Oct 15;168(8):968-75. Epub 2003 Jul 11.
24. RGD automated import pipeline for gene-chemical interactions
25. Rosenthal LA, etal., Virol J. 2009 Aug 11;6:122.
26. Russo RC, etal., Am J Respir Cell Mol Biol. 2009 Apr;40(4):410-21. Epub 2008 Oct 3.
27. Singh V, etal., Transpl Immunol. 2013 Jun;28(4):189-92. doi: 10.1016/j.trim.2013.04.004. Epub 2013 Apr 21.
28. Stevenson CS, etal., Am J Physiol Lung Cell Mol Physiol. 2005 Mar;288(3):L514-22. Epub 2004 Oct 29.
29. Suh JS, etal., J Interferon Cytokine Res. 2011 Jan 8.
30. Svensson M, etal., Kidney Int. 2008 Jul;74(1):81-90. doi: 10.1038/ki.2008.105. Epub 2008 Apr 9.
31. Svensson M, etal., Kidney Int. 2011 Nov;80(10):1064-72. doi: 10.1038/ki.2011.257. Epub 2011 Aug 3.
32. Tateda K, etal., Infect Immun. 2001 Apr;69(4):2017-24.
33. Xiong Y, etal., Emerg Microbes Infect. 2020 Dec;9(1):761-770. doi: 10.1080/22221751.2020.1747363.
34. Yamanaka Y, etal., J Endod. 2012 Mar;38(3):313-7. doi: 10.1016/j.joen.2011.11.009. Epub 2011 Dec 23.
35. Yi M, etal., Am J Respir Crit Care Med. 2004 Dec 1;170(11):1188-96. Epub 2004 Sep 3.
36. Zernecke A, etal., J Immunol. 2001 May 1;166(9):5755-62.
37. Zhou Z, etal., Cell Host Microbe. 2020 Jun 10;27(6):883-890.e2. doi: 10.1016/j.chom.2020.04.017. Epub 2020 May 4.
Additional References at PubMed
PMID:1303245   PMID:1379593   PMID:1427896   PMID:1840701   PMID:1891716   PMID:2834384   PMID:7512557   PMID:7829970   PMID:7929358   PMID:8036519   PMID:8194768   PMID:8195702  
PMID:8294449   PMID:8316840   PMID:8384312   PMID:8550564   PMID:8626516   PMID:8662698   PMID:8702798   PMID:8940121   PMID:9058825   PMID:9079638   PMID:9260277   PMID:9464567  
PMID:9651375   PMID:9692902   PMID:9725262   PMID:9843397   PMID:10438939   PMID:10593335   PMID:10688807   PMID:10725748   PMID:10734056   PMID:10820279   PMID:10878382   PMID:10881932  
PMID:10943863   PMID:11007922   PMID:11023990   PMID:11138777   PMID:11170396   PMID:11196695   PMID:11278485   PMID:11397869   PMID:11435493   PMID:11524231   PMID:11751889   PMID:11818437  
PMID:12164325   PMID:12176324   PMID:12239185   PMID:12442335   PMID:12453441   PMID:12477932   PMID:12496258   PMID:12507773   PMID:12606476   PMID:12620646   PMID:12628493   PMID:12633567  
PMID:12870115   PMID:12888558   PMID:12975484   PMID:14713106   PMID:14967163   PMID:15004234   PMID:15028716   PMID:15063762   PMID:15265017   PMID:15358660   PMID:15364949   PMID:15452121  
PMID:15454487   PMID:15479720   PMID:15489334   PMID:15545821   PMID:15598788   PMID:15618253   PMID:15626158   PMID:15630732   PMID:15772681   PMID:15793866   PMID:15946947   PMID:16086366  
PMID:16098254   PMID:16260092   PMID:16272353   PMID:16344560   PMID:16406804   PMID:16411061   PMID:16621978   PMID:16679868   PMID:16702372   PMID:16793206   PMID:16897191   PMID:16987681  
PMID:16990258   PMID:17003486   PMID:17142783   PMID:17204468   PMID:17272812   PMID:17295203   PMID:17360650   PMID:17435771   PMID:17604950   PMID:17630697   PMID:17672867   PMID:17703412  
PMID:17709521   PMID:17939034   PMID:17949231   PMID:17996233   PMID:18025257   PMID:18199703   PMID:18208820   PMID:18240029   PMID:18244953   PMID:18292390   PMID:18307412   PMID:18462836  
PMID:18508130   PMID:18555777   PMID:18577758   PMID:18633131   PMID:18676870   PMID:18755694   PMID:18780829   PMID:18852457   PMID:19010874   PMID:19012493   PMID:19026125   PMID:19035451  
PMID:19057948   PMID:19067586   PMID:19118103   PMID:19147552   PMID:19151925   PMID:19155217   PMID:19170196   PMID:19258923   PMID:19401689   PMID:19423540   PMID:19435808   PMID:19435811  
PMID:19549892   PMID:19573080   PMID:19585580   PMID:19634663   PMID:19750480   PMID:19773279   PMID:19887480   PMID:19890050   PMID:19904283   PMID:19913121   PMID:20005738   PMID:20016196  
PMID:20016852   PMID:20018298   PMID:20044480   PMID:20056178   PMID:20070156   PMID:20089160   PMID:20140262   PMID:20237496   PMID:20406964   PMID:20419088   PMID:20429924   PMID:20438785  
PMID:20452482   PMID:20453000   PMID:20468071   PMID:20485444   PMID:20503287   PMID:20505188   PMID:20519647   PMID:20540789   PMID:20568250   PMID:20580690   PMID:20628086   PMID:20630874  
PMID:20635912   PMID:20673868   PMID:20802378   PMID:21036625   PMID:21042230   PMID:21106938   PMID:21297633   PMID:21343381   PMID:21441140   PMID:21555225   PMID:21670971   PMID:21749879  
PMID:21873635   PMID:21876773   PMID:21915051   PMID:21948388   PMID:21989491   PMID:22076427   PMID:22088968   PMID:22117410   PMID:22152684   PMID:22171941   PMID:22203670   PMID:22231733  
PMID:22242662   PMID:22274915   PMID:22389383   PMID:22482416   PMID:22617157   PMID:22626766   PMID:22661400   PMID:22763041   PMID:22763101   PMID:22850671   PMID:22885102   PMID:22893608  
PMID:22904195   PMID:22986777   PMID:23023221   PMID:23029099   PMID:23052840   PMID:23128233   PMID:23204236   PMID:23293110   PMID:23389772   PMID:23403077   PMID:23470693   PMID:23479735  
PMID:23548249   PMID:23597562   PMID:23727325   PMID:23758411   PMID:23869868   PMID:23912333   PMID:23972657   PMID:24161763   PMID:24332572   PMID:24338377   PMID:24339979   PMID:24376747  
PMID:24430363   PMID:24450359   PMID:24462138   PMID:24489825   PMID:24510965   PMID:24582495   PMID:24593195   PMID:24623414   PMID:24642259   PMID:24662979   PMID:24678812   PMID:24736615  
PMID:24768637   PMID:24777453   PMID:24883303   PMID:24946112   PMID:24972913   PMID:24989774   PMID:25022956   PMID:25172501   PMID:25339290   PMID:25349304   PMID:25412626   PMID:25456886  
PMID:25462858   PMID:25480945   PMID:25484047   PMID:25484064   PMID:25580640   PMID:25620445   PMID:25622052   PMID:25682075   PMID:25704763   PMID:25757087   PMID:25794662   PMID:25837197  
PMID:26038959   PMID:26058729   PMID:26060478   PMID:26087179   PMID:26111149   PMID:26188847   PMID:26231560   PMID:26267317   PMID:26287498   PMID:26297794   PMID:26302999   PMID:26364720  
PMID:26469385   PMID:26503598   PMID:26519257   PMID:26521741   PMID:26559818   PMID:26648969   PMID:26771140   PMID:26827264   PMID:26837773   PMID:26847910   PMID:27016001   PMID:27052313  
PMID:27058419   PMID:27151689   PMID:27160907   PMID:27188501   PMID:27196318   PMID:27222476   PMID:27265504   PMID:27273823   PMID:27297979   PMID:27324095   PMID:27551720   PMID:27556695  
PMID:27578214   PMID:27606963   PMID:27721403   PMID:27737879   PMID:27807540   PMID:27906878   PMID:27974825   PMID:28151558   PMID:28179147   PMID:28415702   PMID:28481874   PMID:28575019  
PMID:28668699   PMID:28705496   PMID:28964785   PMID:28970523   PMID:29197248   PMID:29369549   PMID:29507619   PMID:29577511   PMID:29676528   PMID:29749433   PMID:29948377   PMID:30086759  
PMID:30096583   PMID:30236892   PMID:30246456   PMID:30341468   PMID:30349936   PMID:30407218   PMID:30630119   PMID:30714340   PMID:30796034   PMID:30863202   PMID:31107242   PMID:31235521  
PMID:31243125   PMID:31364370   PMID:31433989   PMID:31613654   PMID:31654638   PMID:31666007   PMID:31731888   PMID:31851535   PMID:31884679   PMID:32296183   PMID:32610344   PMID:32694731  
PMID:32800946   PMID:32867211   PMID:33000506   PMID:33517283   PMID:33788733   PMID:33807899  


Genomics

Comparative Map Data
CXCR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2218,125,289 - 218,137,251 (+)EnsemblGRCh38hg38GRCh38
GRCh382218,125,294 - 218,137,253 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372218,990,017 - 219,001,974 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362218,698,991 - 218,710,220 (+)NCBINCBI36hg18NCBI36
Build 342218,816,251 - 218,827,481NCBI
Celera2212,756,449 - 212,768,411 (+)NCBI
Cytogenetic Map2q35NCBI
HuRef2210,842,767 - 210,854,732 (+)NCBIHuRef
CHM1_12218,996,503 - 219,008,469 (+)NCBICHM1_1
Cxcr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39174,193,153 - 74,200,405 (+)NCBIGRCm39mm39
GRCm39 Ensembl174,193,148 - 74,200,405 (+)Ensembl
GRCm38174,153,994 - 74,161,246 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl174,153,989 - 74,161,246 (+)EnsemblGRCm38mm10GRCm38
MGSCv37174,200,568 - 74,207,820 (+)NCBIGRCm37mm9NCBIm37
MGSCv36174,087,201 - 74,094,453 (+)NCBImm8
Celera174,715,354 - 74,722,423 (+)NCBICelera
Cytogenetic Map1C3NCBI
cM Map138.41NCBI
Cxcr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2975,729,493 - 75,735,868 (+)NCBI
Rnor_6.0 Ensembl981,427,730 - 81,434,102 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0981,427,275 - 81,435,065 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0981,193,442 - 81,199,814 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4973,470,943 - 73,477,315 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1973,617,924 - 73,624,297 (+)NCBI
Celera973,306,852 - 73,313,224 (+)NCBICelera
Cytogenetic Map9q33NCBI
CXCR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12B223,987,556 - 223,999,511 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B223,997,066 - 223,998,148 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02B105,387,198 - 105,400,533 (+)NCBIMhudiblu_PPA_v0panPan3
CXCR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13724,831,351 - 24,846,387 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3724,843,171 - 24,844,247 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3725,659,341 - 25,664,768 (+)NCBI
ROS_Cfam_1.03724,847,511 - 24,862,398 (+)NCBI
UMICH_Zoey_3.13724,760,631 - 24,766,058 (+)NCBI
UNSW_CanFamBas_1.03724,694,995 - 24,700,420 (+)NCBI
UU_Cfam_GSD_1.03724,714,358 - 24,719,785 (+)NCBI
CXCR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.115120,219,657 - 120,230,203 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215133,275,203 - 133,286,266 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LOC103217855
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110104,012,906 - 104,025,599 (+)NCBI
ChlSab1.1 Ensembl10104,022,811 - 104,023,893 (+)Ensembl
Vero_WHO_p1.0NW_02366604095,376,101 - 95,386,709 (-)NCBI

Position Markers
SHGC-35278  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372219,000,660 - 219,000,876UniSTSGRCh37
GRCh372218,924,793 - 218,925,009UniSTSGRCh37
Build 362218,633,038 - 218,633,254RGDNCBI36
Celera2212,767,094 - 212,767,310UniSTS
Celera2212,692,681 - 212,692,897RGD
Cytogenetic Map2q35UniSTS
HuRef2210,779,165 - 210,779,381UniSTS
HuRef2210,853,415 - 210,853,631UniSTS
Stanford-G3 RH Map28615.0UniSTS
GeneMap99-GB4 RH Map2679.36UniSTS
Whitehead-RH Map21009.2UniSTS
NCBI RH Map21775.4UniSTS
GeneMap99-G3 RH Map29454.0UniSTS
RH69171  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372219,000,583 - 219,000,782UniSTSGRCh37
GRCh372218,924,887 - 218,925,086UniSTSGRCh37
Build 362218,633,132 - 218,633,331RGDNCBI36
Celera2212,767,017 - 212,767,216UniSTS
Celera2212,692,775 - 212,692,974RGD
Cytogenetic Map2q35UniSTS
HuRef2210,779,259 - 210,779,458UniSTS
HuRef2210,853,338 - 210,853,537UniSTS
GeneMap99-GB4 RH Map2680.95UniSTS
IL8R-1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372218,999,980 - 219,000,502UniSTSGRCh37
Build 362218,708,225 - 218,708,747RGDNCBI36
Celera2212,766,414 - 212,766,936RGD
HuRef2210,852,735 - 210,853,257UniSTS
PMC135988P2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372218,999,631 - 219,000,057UniSTSGRCh37
Build 362218,707,876 - 218,708,302RGDNCBI36
Celera2212,766,065 - 212,766,491RGD
Cytogenetic Map2q35UniSTS
HuRef2210,852,386 - 210,852,812UniSTS
PMC155779P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372219,000,289 - 219,000,478UniSTSGRCh37
GRCh372219,029,009 - 219,029,197UniSTSGRCh37
Build 362218,708,534 - 218,708,723RGDNCBI36
Celera2212,795,594 - 212,795,782UniSTS
Celera2212,766,723 - 212,766,912RGD
Cytogenetic Map2q35UniSTS
HuRef2210,881,752 - 210,881,940UniSTS
PMC155779P2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372218,999,843 - 219,000,478UniSTSGRCh37
GRCh372219,029,009 - 219,029,643UniSTSGRCh37
Build 362218,708,088 - 218,708,723RGDNCBI36
Celera2212,795,594 - 212,796,228UniSTS
Celera2212,766,277 - 212,766,912RGD
Cytogenetic Map2q35UniSTS
HuRef2210,881,752 - 210,882,386UniSTS
PMC155779P3  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372218,999,843 - 219,000,092UniSTSGRCh37
Build 362218,708,088 - 218,708,337RGDNCBI36
Celera2212,766,277 - 212,766,526RGD
Cytogenetic Map2q35UniSTS
HuRef2210,852,598 - 210,852,847UniSTS
PMC310709P2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372218,999,774 - 219,000,219UniSTSGRCh37
GRCh372218,925,450 - 218,925,894UniSTSGRCh37
Build 362218,633,695 - 218,634,139RGDNCBI36
Celera2212,693,338 - 212,693,782RGD
Celera2212,766,208 - 212,766,653UniSTS
Cytogenetic Map2q35UniSTS
HuRef2210,882,009 - 210,882,455UniSTS
HuRef2210,779,822 - 210,780,266UniSTS
HuRef2210,852,529 - 210,852,974UniSTS
IL8RB_163  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372219,001,235 - 219,002,016UniSTSGRCh37
Build 362218,709,480 - 218,710,261RGDNCBI36
Celera2212,767,670 - 212,768,451RGD
HuRef2210,853,991 - 210,854,772UniSTS
RH78907  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372219,001,678 - 219,001,862UniSTSGRCh37
Build 362218,709,923 - 218,710,107RGDNCBI36
Celera2212,768,113 - 212,768,297RGD
Cytogenetic Map2q35UniSTS
HuRef2210,854,434 - 210,854,618UniSTS
STS-L19593  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh372219,000,611 - 219,000,813UniSTSGRCh37
GRCh372218,924,856 - 218,925,057UniSTSGRCh37
Build 362218,633,101 - 218,633,302RGDNCBI36
Celera2212,767,045 - 212,767,247UniSTS
Celera2212,692,744 - 212,692,945RGD
Cytogenetic Map2q35UniSTS
HuRef2210,779,228 - 210,779,429UniSTS
HuRef2210,853,366 - 210,853,568UniSTS
NCBI RH Map21734.1UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1841
Count of miRNA genes:736
Interacting mature miRNAs:825
Transcripts:ENST00000318507, ENST00000415392, ENST00000418878, ENST00000428565, ENST00000449014, ENST00000453237, ENST00000454148
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High 102 102
Medium 9 660 2 22 892 3 15 5 2 7 79 229 20 58 5
Low 538 702 536 329 371 244 2132 331 553 178 397 670 88 806 968 2
Below cutoff 1733 1467 1113 231 457 176 2073 1759 2951 175 868 521 61 339 1745 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_052975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001168298 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001557 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005246530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017003990 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017003991 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017003992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB032733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB032734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC124768 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH005384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ710879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK290906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312664 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY714242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC037961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA670033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA674925 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HI519532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L19593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M73969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M94582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M99412 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U11872 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U11873 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U11874 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U11875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U11876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U11877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U11878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000318507   ⟹   ENSP00000319635
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2218,126,028 - 218,137,251 (+)Ensembl
RefSeq Acc Id: ENST00000415392   ⟹   ENSP00000392348
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2218,125,681 - 218,135,216 (+)Ensembl
RefSeq Acc Id: ENST00000418878   ⟹   ENSP00000416815
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2218,130,850 - 218,134,846 (+)Ensembl
RefSeq Acc Id: ENST00000428565   ⟹   ENSP00000392698
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2218,129,287 - 218,135,318 (+)Ensembl
RefSeq Acc Id: ENST00000449014   ⟹   ENSP00000410506
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2218,125,705 - 218,134,846 (+)Ensembl
RefSeq Acc Id: ENST00000453237   ⟹   ENSP00000413686
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2218,125,289 - 218,135,403 (+)Ensembl
RefSeq Acc Id: ENST00000454148   ⟹   ENSP00000415148
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl2218,126,019 - 218,135,208 (+)Ensembl
RefSeq Acc Id: NM_001168298   ⟹   NP_001161770
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382218,125,294 - 218,137,251 (+)NCBI
GRCh372218,990,013 - 219,001,976 (+)NCBI
HuRef2210,842,767 - 210,854,732 (+)ENTREZGENE
CHM1_12218,996,503 - 219,008,469 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001557   ⟹   NP_001548
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382218,126,028 - 218,137,251 (+)NCBI
GRCh372218,990,013 - 219,001,976 (+)ENTREZGENE
GRCh372218,990,013 - 219,001,976 (+)NCBI
Build 362218,698,991 - 218,710,220 (+)NCBI Archive
HuRef2210,842,767 - 210,854,732 (+)ENTREZGENE
CHM1_12218,997,225 - 219,008,469 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005246530   ⟹   XP_005246587
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382218,126,019 - 218,137,253 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017003990   ⟹   XP_016859479
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382218,125,681 - 218,137,253 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017003991   ⟹   XP_016859480
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382218,129,310 - 218,137,253 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017003992   ⟹   XP_016859481
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh382218,126,028 - 218,137,253 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001161770   ⟸   NM_001168298
- UniProtKB: P25025 (UniProtKB/Swiss-Prot),   Q53PC4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001548   ⟸   NM_001557
- UniProtKB: P25025 (UniProtKB/Swiss-Prot),   Q53PC4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005246587   ⟸   XM_005246530
- Peptide Label: isoform X1
- UniProtKB: P25025 (UniProtKB/Swiss-Prot),   Q53PC4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016859479   ⟸   XM_017003990
- Peptide Label: isoform X1
- UniProtKB: P25025 (UniProtKB/Swiss-Prot),   Q53PC4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016859481   ⟸   XM_017003992
- Peptide Label: isoform X1
- UniProtKB: P25025 (UniProtKB/Swiss-Prot),   Q53PC4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_016859480   ⟸   XM_017003991
- Peptide Label: isoform X1
- UniProtKB: P25025 (UniProtKB/Swiss-Prot),   Q53PC4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000392698   ⟸   ENST00000428565
RefSeq Acc Id: ENSP00000413686   ⟸   ENST00000453237
RefSeq Acc Id: ENSP00000415148   ⟸   ENST00000454148
RefSeq Acc Id: ENSP00000392348   ⟸   ENST00000415392
RefSeq Acc Id: ENSP00000416815   ⟸   ENST00000418878
RefSeq Acc Id: ENSP00000410506   ⟸   ENST00000449014
RefSeq Acc Id: ENSP00000319635   ⟸   ENST00000318507
Protein Domains
G_PROTEIN_RECEP_F1_2

Promoters
RGD ID:6862774
Promoter ID:EPDNEW_H4552
Type:initiation region
Name:CXCR2_4
Description:C-X-C motif chemokine receptor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H4553  EPDNEW_H4554  EPDNEW_H4555  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382218,125,294 - 218,125,354EPDNEW
RGD ID:6862776
Promoter ID:EPDNEW_H4553
Type:initiation region
Name:CXCR2_3
Description:C-X-C motif chemokine receptor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H4552  EPDNEW_H4554  EPDNEW_H4555  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382218,125,718 - 218,125,778EPDNEW
RGD ID:6862778
Promoter ID:EPDNEW_H4554
Type:initiation region
Name:CXCR2_1
Description:C-X-C motif chemokine receptor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H4552  EPDNEW_H4553  EPDNEW_H4555  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382218,126,028 - 218,126,088EPDNEW
RGD ID:6862780
Promoter ID:EPDNEW_H4555
Type:initiation region
Name:CXCR2_2
Description:C-X-C motif chemokine receptor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H4552  EPDNEW_H4553  EPDNEW_H4554  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh382218,129,317 - 218,129,377EPDNEW
RGD ID:6797657
Promoter ID:HG_KWN:37191
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Lymphoblastoid,   NB4
Transcripts:OTTHUMT00000256772,   OTTHUMT00000338837,   OTTHUMT00000338841,   UC002VGZ.1,   UC002VHB.1
Position:
Human AssemblyChrPosition (strand)Source
Build 362218,698,581 - 218,699,081 (+)MPROMDB
RGD ID:6850200
Promoter ID:EP57007
Type:initiation region
Name:HS_IL8RB
Description:Interleukin-8 receptor B (IL-8R B), member of the G-protein-coupledrhodopsin superfamily of receptors, IL8RB or CXCR2 gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Tissues & Cell Lines:neutrophil
Experiment Methods:Sequencing of a full-length cDNA
Position:
Human AssemblyChrPosition (strand)Source
Build 362218,699,020 - 218,699,080EPD

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 2q32.3-37.3(chr2:194898783-236473913)x3 copy number gain See cases [RCV000051119] Chr2:194898783..236473913 [GRCh38]
Chr2:195763507..237382556 [GRCh37]
Chr2:195471752..237047295 [NCBI36]
Chr2:2q32.3-37.3
pathogenic
GRCh38/hg38 2q32.2-37.3(chr2:188818195-242065208)x3 copy number gain See cases [RCV000052958] Chr2:188818195..242065208 [GRCh38]
Chr2:189682921..243007359 [GRCh37]
Chr2:189391166..242656032 [NCBI36]
Chr2:2q32.2-37.3
pathogenic
GRCh38/hg38 2q32.2-37.3(chr2:190310736-241892770)x3 copy number gain See cases [RCV000052959] Chr2:190310736..241892770 [GRCh38]
Chr2:191175462..242834921 [GRCh37]
Chr2:190883707..242483594 [NCBI36]
Chr2:2q32.2-37.3
pathogenic
GRCh38/hg38 2q32.3-37.3(chr2:193122313-241074980)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052960]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052960]|See cases [RCV000052960] Chr2:193122313..241074980 [GRCh38]
Chr2:193987039..242014395 [GRCh37]
Chr2:193695284..241663068 [NCBI36]
Chr2:2q32.3-37.3
pathogenic
GRCh38/hg38 2q34-36.3(chr2:212614422-227121230)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052964]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052964]|See cases [RCV000052964] Chr2:212614422..227121230 [GRCh38]
Chr2:213479146..227985946 [GRCh37]
Chr2:213187391..227694190 [NCBI36]
Chr2:2q34-36.3
pathogenic
GRCh38/hg38 2q34-37.3(chr2:210579676-242126245)x3 copy number gain See cases [RCV000135934] Chr2:210579676..242126245 [GRCh38]
Chr2:211444400..243059659 [GRCh37]
Chr2:211152645..242717069 [NCBI36]
Chr2:2q34-37.3
pathogenic
GRCh38/hg38 2q31.3-36.2(chr2:180513793-224302848)x3 copy number gain See cases [RCV000139446] Chr2:180513793..224302848 [GRCh38]
Chr2:181378520..225167565 [GRCh37]
Chr2:181086765..224875809 [NCBI36]
Chr2:2q31.3-36.2
pathogenic
GRCh38/hg38 2q32.2-37.3(chr2:189436149-241841232)x3 copy number gain See cases [RCV000142307] Chr2:189436149..241841232 [GRCh38]
Chr2:190300875..242783384 [GRCh37]
Chr2:190009120..242432057 [NCBI36]
Chr2:2q32.2-37.3
pathogenic
GRCh38/hg38 2q35-37.3(chr2:218101759-242126245)x3 copy number gain See cases [RCV000143216] Chr2:218101759..242126245 [GRCh38]
Chr2:218966482..243059659 [GRCh37]
Chr2:218674727..242717069 [NCBI36]
Chr2:2q35-37.3
pathogenic
NM_001557.4(CXCR2):c.235G>A (p.Gly79Ser) single nucleotide variant not provided [RCV000903661]|not specified [RCV000239194] Chr2:218135036 [GRCh38]
Chr2:218999759 [GRCh37]
Chr2:2q35
likely benign
GRCh37/hg19 2q35-36.3(chr2:217374144-227643620)x1 copy number loss not provided [RCV000585275] Chr2:217374144..227643620 [GRCh37]
Chr2:2q35-36.3
likely pathogenic
GRCh37/hg19 2q35(chr2:218647714-219053933) copy number gain Abnormality of esophagus morphology [RCV000416700] Chr2:218647714..219053933 [GRCh37]
Chr2:2q35
uncertain significance
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384) copy number gain See cases [RCV000512056] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2q34-37.3(chr2:213518431-242783384)x3 copy number gain See cases [RCV000512009] Chr2:213518431..242783384 [GRCh37]
Chr2:2q34-37.3
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:12771-242783384)x3 copy number gain See cases [RCV000511212] Chr2:12771..242783384 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
NM_001557.4(CXCR2):c.707G>A (p.Arg236His) single nucleotide variant not provided [RCV000658899] Chr2:218135508 [GRCh38]
Chr2:219000231 [GRCh37]
Chr2:2q35
uncertain significance
GRCh37/hg19 2q35-36.3(chr2:218813434-227450699)x1 copy number loss not provided [RCV000682163] Chr2:218813434..227450699 [GRCh37]
Chr2:2q35-36.3
pathogenic
GRCh37/hg19 2q33.3-35(chr2:205169148-219149293)x3 copy number gain not provided [RCV000682166] Chr2:205169148..219149293 [GRCh37]
Chr2:2q33.3-35
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:14238-243048760)x3 copy number gain not provided [RCV000752802] Chr2:14238..243048760 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
GRCh37/hg19 2p25.3-q37.3(chr2:15672-243101834)x3 copy number gain not provided [RCV000752804] Chr2:15672..243101834 [GRCh37]
Chr2:2p25.3-q37.3
pathogenic
NM_001557.4(CXCR2):c.472A>T (p.Lys158Ter) single nucleotide variant not provided [RCV000997660] Chr2:218135273 [GRCh38]
Chr2:218999996 [GRCh37]
Chr2:2q35
likely pathogenic
NM_001557.4(CXCR2):c.476G>T (p.Arg159Leu) single nucleotide variant not provided [RCV000997661] Chr2:218135277 [GRCh38]
Chr2:219000000 [GRCh37]
Chr2:2q35
uncertain significance
NM_001557.4(CXCR2):c.87G>T (p.Leu29=) single nucleotide variant not provided [RCV000926498] Chr2:218134888 [GRCh38]
Chr2:218999611 [GRCh37]
Chr2:2q35
likely benign
NM_001557.4(CXCR2):c.663C>T (p.Ile221=) single nucleotide variant not provided [RCV000902864] Chr2:218135464 [GRCh38]
Chr2:219000187 [GRCh37]
Chr2:2q35
likely benign
NM_001557.4(CXCR2):c.1041C>T (p.Ser347=) single nucleotide variant not provided [RCV000946677] Chr2:218135842 [GRCh38]
Chr2:219000565 [GRCh37]
Chr2:2q35
benign
GRCh37/hg19 2q35(chr2:218271898-219825640) copy number gain not provided [RCV000767784] Chr2:218271898..219825640 [GRCh37]
Chr2:2q35
likely pathogenic
NM_001557.4(CXCR2):c.669A>G (p.Pro223=) single nucleotide variant not provided [RCV000960127] Chr2:218135470 [GRCh38]
Chr2:219000193 [GRCh37]
Chr2:2q35
benign
NM_001557.4(CXCR2):c.488A>T (p.Lys163Ile) single nucleotide variant not provided [RCV000997662] Chr2:218135289 [GRCh38]
Chr2:219000012 [GRCh37]
Chr2:2q35
uncertain significance
NM_001557.4(CXCR2):c.458G>A (p.Arg153His) single nucleotide variant not provided [RCV000997659] Chr2:218135259 [GRCh38]
Chr2:218999982 [GRCh37]
Chr2:2q35
uncertain significance
Single allele duplication Neurodevelopmental disorder [RCV000787403] Chr2:188926928..225298653 [GRCh37]
Chr2:2q32.1-36.2
pathogenic
GRCh37/hg19 2q34-37.3(chr2:210779657-239879183)x3 copy number gain See cases [RCV000790568] Chr2:210779657..239879183 [GRCh37]
Chr2:2q34-37.3
pathogenic
NM_001557.4(CXCR2):c.721G>A (p.Ala241Thr) single nucleotide variant not provided [RCV000892609] Chr2:218135522 [GRCh38]
Chr2:219000245 [GRCh37]
Chr2:2q35
benign
NM_001557.4(CXCR2):c.1075A>T (p.Thr359Ser) single nucleotide variant not provided [RCV000997663] Chr2:218135876 [GRCh38]
Chr2:219000599 [GRCh37]
Chr2:2q35
uncertain significance
NM_001557.4(CXCR2):c.90C>T (p.Pro30=) single nucleotide variant not provided [RCV000909356] Chr2:218134891 [GRCh38]
Chr2:218999614 [GRCh37]
Chr2:2q35
benign
GRCh37/hg19 2q35(chr2:216883237-220953003)x3 copy number gain not provided [RCV001007510] Chr2:216883237..220953003 [GRCh37]
Chr2:2q35
pathogenic
GRCh37/hg19 2q34-35(chr2:215122019-220397907)x1 copy number loss not provided [RCV001259180] Chr2:215122019..220397907 [GRCh37]
Chr2:2q34-35
likely pathogenic
GRCh37/hg19 2q31.2-37.3(chr2:178397959-243007457)x3 copy number gain See cases [RCV001263052] Chr2:178397959..243007457 [GRCh37]
Chr2:2q31.2-37.3
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:6027 AgrOrtholog
COSMIC CXCR2 COSMIC
Ensembl Genes ENSG00000180871 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000319635 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000392348 UniProtKB/TrEMBL
  ENSP00000392698 UniProtKB/TrEMBL
  ENSP00000410506 UniProtKB/TrEMBL
  ENSP00000413686 UniProtKB/TrEMBL
  ENSP00000415148 UniProtKB/TrEMBL
  ENSP00000416815 UniProtKB/TrEMBL
Ensembl Transcript ENST00000318507 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000415392 UniProtKB/TrEMBL
  ENST00000418878 UniProtKB/TrEMBL
  ENST00000428565 UniProtKB/TrEMBL
  ENST00000449014 UniProtKB/TrEMBL
  ENST00000453237 UniProtKB/TrEMBL
  ENST00000454148 UniProtKB/TrEMBL
GTEx ENSG00000180871 GTEx
HGNC ID HGNC:6027 ENTREZGENE
Human Proteome Map CXCR2 Human Proteome Map
InterPro Chemokine_CXCR2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_CXCR_1/2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:3579 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 3579 ENTREZGENE
OMIM 146928 OMIM
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA29843 PharmGKB
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTRLEUKIN8R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTRLEUKN8BR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt C9J1J7_HUMAN UniProtKB/TrEMBL
  C9J2F9_HUMAN UniProtKB/TrEMBL
  C9JG19_HUMAN UniProtKB/TrEMBL
  C9JW47_HUMAN UniProtKB/TrEMBL
  CXCR2_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q53PC4 ENTREZGENE, UniProtKB/TrEMBL
  Q6LCZ7_HUMAN UniProtKB/TrEMBL
UniProt Secondary Q8IUZ1 UniProtKB/Swiss-Prot
  Q9P2T6 UniProtKB/Swiss-Prot
  Q9P2T7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-21 CXCR2  C-X-C motif chemokine receptor 2    chemokine (C-X-C motif) receptor 2  Symbol and/or name change 5135510 APPROVED
2011-08-16 CXCR2  chemokine (C-X-C motif) receptor 2  CXCR2  chemokine (C-X-C motif) receptor 2  Symbol and/or name change 5135510 APPROVED
2011-07-27 CXCR2  chemokine (C-X-C motif) receptor 2  IL8RB  interleukin 8 receptor, beta  Symbol and/or name change 5135510 APPROVED