C3 (complement C3) - Rat Genome Database

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Gene: C3 (complement C3) Homo sapiens
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Symbol: C3
Name: complement C3
RGD ID: 735504
HGNC Page HGNC:1318
Description: Enables C5L2 anaphylatoxin chemotactic receptor binding activity. Involved in several processes, including opsonization; positive regulation of macromolecule metabolic process; and positive regulation of phagocytosis. Located in extracellular space; plasma membrane; and serine-type endopeptidase complex. Implicated in several diseases, including complement deficiency (multiple); macular degeneration (multiple); paroxysmal nocturnal hemoglobinuria; sickle cell anemia; and silicosis. Biomarker of several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); glomerulonephritis (multiple); and lung disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: acylation-stimulating protein cleavage product; AHUS5; ARMD9; ASP; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1; C3a; C3a anaphylatoxin; C3b; complement component 3; complement component C3; complement component C3a; complement component C3b; CPAMD1; epididymis secretory sperm binding protein Li 62p; HEL-S-62p; prepro-C3
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: C3P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38196,677,704 - 6,720,650 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl196,677,704 - 6,730,562 (-)EnsemblGRCh38hg38GRCh38
GRCh37196,677,715 - 6,720,661 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36196,628,846 - 6,671,662 (-)NCBINCBI36Build 36hg18NCBI36
Build 34196,628,877 - 6,671,660NCBI
Celera196,619,402 - 6,662,926 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef196,440,030 - 6,483,146 (-)NCBIHuRef
CHM1_1196,678,095 - 6,720,521 (-)NCBICHM1_1
T2T-CHM13v2.0196,667,334 - 6,710,056 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (EXP)
Acute Lung Injury  (ISO)
acute myocardial infarction  (IEP)
adult respiratory distress syndrome  (IEP)
age related macular degeneration 7  (IAGP)
age related macular degeneration 9  (IAGP)
Alzheimer's disease  (IAGP)
amyotrophic lateral sclerosis  (ISO)
anterior uveitis  (IEP,ISO)
arteriolosclerosis  (IEP)
asthma  (IAGP,IEP,ISO)
atopic dermatitis  (IEP)
atypical hemolytic-uremic syndrome  (EXP,IAGP,ISO)
autosomal recessive polycystic kidney disease  (IEP,ISO)
bacterial pneumonia  (ISO)
boutonneuse fever  (IEP)
Brain Injuries  (ISO)
brain ischemia  (ISO)
Carcinoma, Lewis Lung  (ISO)
Cerebral Hemorrhage  (ISO)
Chemical and Drug Induced Liver Injury  (EXP)
Chronic Allograft Dysfunction  (ISO)
chronic obstructive pulmonary disease  (IEP)
complement component 3 deficiency  (IAGP)
congenital hemolytic anemia  (IAGP)
conjunctivitis  (IEP)
COVID-19  (IAGP,IEP)
Diabetic Nephropathies  (ISO)
Drug-Related Side Effects and Adverse Reactions  (EXP)
erythema nodosum  (IEP)
Experimental Arthritis  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Myasthenia Gravis  (ISO)
Experimental Autoimmune Uveoretinitis  (ISO)
factor VIII deficiency  (IEP)
focal segmental glomerulosclerosis  (IAGP)
focal segmental glomerulosclerosis 1  (IAGP)
Fuchs' endothelial dystrophy  (IEP)
genetic disease  (IAGP)
glomerulonephritis  (ISO)
Hematuria  (IEP)
Henoch-Schoenlein purpura  (EXP)
hepatocellular carcinoma  (ISO)
herpes simplex  (ISO)
Herpesviridae Infections  (ISO)
high grade glioma  (ISO)
human immunodeficiency virus infectious disease  (IEP)
Human Influenza  (ISO)
Hyperalgesia  (ISO)
hypertension  (ISO)
IgA glomerulonephritis  (IEP)
Insulin Resistance  (EXP)
kidney disease  (IAGP)
Kidney Reperfusion Injury  (ISO)
Kuhnt-Junius degeneration  (IAGP)
leishmaniasis  (ISO)
lepromatous leprosy  (IEP)
Liver Reperfusion Injury  (ISO)
lung disease  (ISO)
lupus nephritis  (EXP,IEP)
macular degeneration  (EXP,IAGP,ISO)
mastitis  (ISO)
melanoma  (ISO)
membranoproliferative glomerulonephritis  (IAGP)
membranous glomerulonephritis  (EXP,ISO)
Meningococcal Infections  (IEP)
Metabolic Syndrome  (IEP)
middle cerebral artery infarction  (EXP,ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
obesity  (ISO)
ocular hypertension  (IEP)
Optic Nerve Injuries  (ISO)
otitis media  (ISO)
Otitis Media with Effusion  (IEP)
Paratuberculosis  (EXP)
paroxysmal nocturnal hemoglobinuria  (IDA)
pemphigus  (EXP)
Penetrating Wounds  (IDA)
pleurisy  (ISO)
Pneumococcal Pneumonia  (IEP,ISO)
pneumocystosis  (ISO)
pneumonia  (ISO)
pre-eclampsia  (ISO)
primary immunodeficiency disease  (EXP)
primary ovarian insufficiency  (IAGP)
pulmonary eosinophilia  (ISO)
pulmonary sarcoidosis  (IEP)
pulmonary tuberculosis  (IEP)
Radiation Pneumonitis  (IEP)
Refractory Anemia with Excess of Blasts  (IEP)
Reperfusion Injury  (ISO)
retinal degeneration  (ISO)
rheumatoid arthritis  (IEP)
rhinitis  (IEP,ISO)
Rhinosinusitis  (IEP)
sciatic neuropathy  (ISO)
Sepsis  (ISO)
sickle cell anemia  (IDA,IEP)
silicosis  (IAGP)
Sjogren's syndrome  (ISO)
Subarachnoid Hemorrhage  (ISO)
systemic lupus erythematosus  (IDA)
systemic scleroderma  (IEP)
thrombophilia  (ISO)
Thrombotic Microangiopathies  (ISO)
transient cerebral ischemia  (EXP,ISO)
tropical spastic paraparesis  (IEP)
type 1 diabetes mellitus  (IEP)
type 2 diabetes mellitus  (EXP)
Viral Bronchiolitis  (IAGP,ISO)
vitiligo  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(S)-colchicine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
1-Hydroxypyrene  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-dichloroaniline  (EXP,ISO)
3-methylcholanthrene  (EXP,ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
4-tert-Octylphenol  (ISO)
6-propyl-2-thiouracil  (ISO)
7,12-dimethyltetraphene  (ISO)
9-phenanthrol  (EXP)
acetamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP)
aluminium oxide  (ISO)
ammonium chloride  (ISO)
amphibole asbestos  (ISO)
antirheumatic drug  (EXP)
aristolochic acid A  (EXP,ISO)
arsenite(3-)  (EXP)
arsenous acid  (EXP)
atorvastatin calcium  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
bexarotene  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butyric acid  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (ISO)
calciol  (ISO)
carbon nanotube  (EXP,ISO)
chlordecone  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (ISO)
chondroitin sulfate  (EXP)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
corticosterone  (ISO)
crocidolite asbestos  (EXP)
Cuprizon  (ISO)
curcumin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cylindrospermopsin  (ISO)
D-glucose  (ISO)
D-penicillamine  (ISO)
daidzein  (ISO)
danazol  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP)
diethyl malate  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
diuron  (EXP,ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
entinostat  (EXP)
fenthion  (ISO)
fenvalerate  (EXP)
ferulic acid  (ISO)
flutamide  (ISO)
folic acid  (EXP,ISO)
fulvestrant  (EXP,ISO)
furan  (ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
glucose  (ISO)
glycidol  (ISO)
glyphosate  (ISO)
gold atom  (EXP)
gold(0)  (EXP)
GW 4064  (ISO)
heparin  (EXP)
hydrazine  (ISO)
hydrogen peroxide  (EXP)
ibuprofen  (EXP)
isoflavones  (ISO)
isoprenaline  (EXP,ISO)
isotretinoin  (EXP)
ivermectin  (EXP)
L-ascorbic acid  (ISO)
lead(0)  (EXP)
lead(2+)  (EXP)
levonorgestrel  (ISO)
lipopolysaccharide  (ISO)
magnesium atom  (ISO)
mangiferin  (ISO)
medroxyprogesterone acetate  (ISO)
mercury atom  (EXP)
mercury dichloride  (ISO)
mercury(0)  (EXP)
methacholine chloride  (ISO)
methidathion  (ISO)
methotrexate  (EXP,ISO)
methoxychlor  (ISO)
methylmercury chloride  (ISO)
methyltestosterone  (EXP)
mifepristone  (ISO)
Mizoribine  (ISO)
mycotoxin  (ISO)
N-acetyl-L-cysteine  (ISO)
N-Acetyl-S-(1,2-dichlorovinyl)-cysteine  (EXP)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
neoechinulin A  (ISO)
nickel atom  (EXP)
nickel dichloride  (ISO)
nickel subsulfide  (ISO)
nilotinib  (ISO)
nitrofen  (ISO)
nitroglycerin  (EXP)
Nonylphenol  (ISO)
olanzapine  (EXP)
ozone  (ISO)
p-tert-Amylphenol  (ISO)
paclitaxel  (ISO)
panobinostat  (EXP)
paracetamol  (EXP,ISO)
PCB138  (ISO)
pemetrexed  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
pirinixic acid  (ISO)
poly(styrene)  (EXP)
potassium chromate  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
procymidone  (ISO)
progesterone  (ISO)
propofol  (EXP)
raloxifene  (ISO)
reactive oxygen species  (ISO)
reserpine  (ISO)
resveratrol  (EXP,ISO)
rofecoxib  (EXP)
rosuvastatin calcium  (ISO)
rotenone  (ISO)
SB 431542  (EXP)
senecionine  (ISO)
serpentine asbestos  (EXP)
silicon dioxide  (EXP)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
Soman  (ISO)
sophoraflavanone B  (ISO)
succimer  (ISO)
sulforaphane  (EXP)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thalidomide  (EXP)
thioacetamide  (ISO)
titanium dioxide  (ISO)
toluene  (ISO)
trichloroethene  (ISO)
triclosan  (EXP,ISO)
trimegestone  (ISO)
trimellitic anhydride  (ISO)
Triptolide  (ISO)
troglitazone  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (ISO)
zearalenone  (ISO)
zinc atom  (EXP)
zinc dichloride  (EXP)
zinc sulfate  (ISO)
zinc(0)  (EXP)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amyloid-beta clearance  (IEA,ISS)
blood coagulation  (ISO)
cell surface receptor signaling pathway involved in cell-cell signaling  (IEA)
complement activation  (IBA,IDA,IEA,IMP,ISO,NAS)
complement activation, alternative pathway  (IEA)
complement activation, classical pathway  (IEA)
complement-dependent cytotoxicity  (IEA,ISO)
complement-mediated synapse pruning  (IEA,ISS)
fatty acid metabolic process  (IEA)
G protein-coupled receptor signaling pathway  (TAS)
immune response  (IEA,TAS)
immune system process  (IEA)
inflammatory response  (IEA)
innate immune response  (IEA)
lipid metabolic process  (IEA)
negative regulation of endopeptidase activity  (IEA)
neuron remodeling  (IEA,ISS)
opsonization  (IDA)
oviduct epithelium development  (IEA,ISO)
positive regulation of activation of membrane attack complex  (IEA)
positive regulation of angiogenesis  (IEA)
positive regulation of apoptotic cell clearance  (IMP)
positive regulation of apoptotic process in another organism  (NAS)
positive regulation of developmental growth  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of G protein-coupled receptor signaling pathway  (IDA)
positive regulation of glucose transmembrane transport  (IDA)
positive regulation of immune response  (NAS)
positive regulation of lipid storage  (IDA)
positive regulation of opsonization  (IDA,NAS)
positive regulation of phagocytosis  (IEA,ISO,NAS)
positive regulation of phagocytosis, engulfment  (IEA,ISS)
positive regulation of protein phosphorylation  (IDA)
positive regulation of receptor-mediated endocytosis  (IEA,ISS)
positive regulation of type IIa hypersensitivity  (IEA,ISO)
positive regulation of vascular endothelial growth factor production  (IDA)
proteolysis  (IDA)
regulation of complement activation  (IDA)
regulation of complement activation, alternative pathway  (IDA)
regulation of triglyceride biosynthetic process  (IDA)
response to bacterium  (IEA,ISO)
response to estradiol  (ISO)
response to estrogen  (ISO)
response to glucocorticoid  (ISO)
response to magnesium ion  (ISO)
response to progesterone  (ISO)
response to xenobiotic stimulus  (ISO)
retina development in camera-type eye  (ISO)
signal transduction  (TAS)
tolerance induction  (ISO)
vascular associated smooth muscle cell differentiation  (ISO)
vertebrate eye-specific patterning  (IEA,ISS)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Complement components (C3, C4) as inflammatory markers in asthma. Abdel Fattah M, etal., Indian J Pediatr. 2010 Jul;77(7):771-3. Epub 2010 Jun 29.
2. Intraglomerular synthesis of complement C3 and its activation products in IgA nephropathy. Abe K, etal., Nephron. 2001 Mar;87(3):231-9.
3. C-reactive protein and complement components but not other acute-phase reactants discriminate between clinical subsets and organ damage in systemic lupus erythematosus. Amezcua-Guerra LM, etal., Clin Lab. 2011;57(7-8):607-13.
4. Treatment with captopril abrogates the altered expression of alpha1 macroglobulin and alpha1 antiproteinase in sera of spontaneously hypertensive rats. Aminudin N, etal., Proteome Sci. 2012 Mar 15;10(1):17. doi: 10.1186/1477-5956-10-17.
5. Complement proteins and C3 anaphylatoxin in the tears of patients with conjunctivitis. Ballow M, etal., J Allergy Clin Immunol. 1985 Sep;76(3):473-6.
6. Variants in the gene encoding C3 are associated with asthma and related phenotypes among African Caribbean families. Barnes KC, etal., Genes Immun. 2006 Jan;7(1):27-35.
7. Complement abnormalities during an epidemic of group B meningococcal infection in children. Beatty DW, etal., Clin Exp Immunol. 1986 Jun;64(3):465-70.
8. Up-regulation of endothelial cell adhesion molecules characterizes disease activity in systemic lupus erythematosus. The Shwartzman phenomenon revisited. Belmont HM, etal., Arthritis Rheum. 1994 Mar;37(3):376-83.
9. Dynamics of intrapulmonary bacterial growth in a murine model of repeated microaspiration. Ben-David I, etal., Am J Respir Cell Mol Biol. 2005 Nov;33(5):476-82. Epub 2005 Jul 13.
10. Molecular basis of hereditary C3 deficiency. Botto M, etal., J Clin Invest. 1990 Oct;86(4):1158-63.
11. Plasma proteomic analysis may identify new markers for radiation-induced lung toxicity in patients with non-small-cell lung cancer. Cai XW, etal., Int J Radiat Oncol Biol Phys. 2010 Jul 1;77(3):867-76.
12. Proteomic analysis of rat plasma following transient focal cerebral ischemia. Chen R, etal., Biomark Med. 2011 Dec;5(6):837-46.
13. Beneficial effect of the polysaccharides from Bupleurum smithii var. parvifolium on "two-hit" acute lung injury in rats. Cheng XQ, etal., Inflammation. 2012 Oct;35(5):1715-22. doi: 10.1007/s10753-012-9489-7.
14. Increased activation of the alternative complement pathway in sickle cell disease. Chudwin DS, etal., Clin Immunol Immunopathol. 1985 Oct;37(1):93-7.
15. Complement deposition and microglial activation in the outer retina in light-induced retinopathy: inhibition by a 5-HT1A agonist. Collier RJ, etal., Invest Ophthalmol Vis Sci. 2011 Oct 11;52(11):8108-16. doi: 10.1167/iovs.10-6418.
16. Complement levels in pneumococcal pneumonia. Coonrod JD and Rylko-Bauer B, Infect Immun. 1977 Oct;18(1):14-22.
17. Complement activation contributes to hypoxic-ischemic brain injury in neonatal rats. Cowell RM, etal., J Neurosci. 2003 Oct 15;23(28):9459-68.
18. Increased serum complement component 3 and mannose-binding lectin levels in adult Chinese patients with chronic rhinosinusitis. Cui YH, etal., Rhinology. 2009 Jun;47(2):187-91.
19. Intravenous immunoglobulin (IVIG) attenuates antibody binding in acute haemorrhagic immunopneumonitis in a rat model of complement-dependent lung injury. Dantas M, etal., Clin Exp Immunol. 2000 Jul;121(1):139-45.
20. Cutting edge: the absence of C3 demonstrates a role for complement in Th2 effector functions in a murine model of pulmonary allergy. Drouin SM, etal., J Immunol. 2001 Oct 15;167(8):4141-5.
21. Endogenous C1-inhibitor production and expression in the heart after acute myocardial infarction. Emmens RW, etal., Cardiovasc Pathol. 2016 Jan-Feb;25(1):33-9. doi: 10.1016/j.carpath.2015.09.006. Epub 2015 Sep 25.
22. CD36-mediated hematoma absorption following intracerebral hemorrhage: negative regulation by TLR4 signaling. Fang H, etal., J Immunol. 2014 Jun 15;192(12):5984-92. doi: 10.4049/jimmunol.1400054. Epub 2014 May 7.
23. Autoantibodies in patients with chronic obstructive pulmonary disease. Feghali-Bostwick CA, etal., Am J Respir Crit Care Med. 2008 Jan 15;177(2):156-63. Epub 2007 Nov 1.
24. The complement anaphylatoxin C5a induces apoptosis in adrenomedullary cells during experimental sepsis. Flierl MA, etal., PLoS One. 2008 Jul 2;3(7):e2560.
25. Anti-ischemia/reperfusion of C1 inhibitor in myocardial cell injury via regulation of local myocardial C3 activity. Fu J, etal., Biochem Biophys Res Commun. 2006 Nov 10;350(1):162-8. Epub 2006 Sep 15.
26. A single localized dose of enzyme-responsive hydrogel improves long-term survival of a vascularized composite allograft. Gajanayake T, etal., Sci Transl Med. 2014 Aug 13;6(249):249ra110. doi: 10.1126/scitranslmed.3008778.
27. Vaccinia virus complement control protein (VCP) improves kidney structure and function following ischemia/reperfusion injury in rats. Ghebremariam YT, etal., J Surg Res. 2010 Apr;159(2):747-54. doi: 10.1016/j.jss.2009.04.049. Epub 2009 Jun 6.
28. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
29. CD36 deficiency increases insulin sensitivity in muscle, but induces insulin resistance in the liver in mice. Goudriaan JR, etal., J Lipid Res. 2003 Dec;44(12):2270-7. Epub 2003 Aug 16.
30. A murine model for the study of mycotic mastitis. Guhad FA, etal., J Comp Pathol. 1995 Nov;113(4):315-25.
31. Variations in the C3, C3a receptor, and C5 genes affect susceptibility to bronchial asthma. Hasegawa K, etal., Hum Genet. 2004 Sep;115(4):295-301.
32. Inhibition of classical complement activation attenuates liver ischaemia and reperfusion injury in a rat model. Heijnen BH, etal., Clin Exp Immunol. 2006 Jan;143(1):15-23.
33. The complement system in Mediterranean spotted fever. Herrero-Herrero JI, etal., J Infect Dis. 1988 May;157(5):1093-5.
34. Complement component C3 plays a critical role in protecting the aging retina in a murine model of age-related macular degeneration. Hoh Kam J, etal., Am J Pathol. 2013 Aug;183(2):480-92. doi: 10.1016/j.ajpath.2013.04.008. Epub 2013 Jun 6.
35. Effect of the C3a-receptor antagonist SB 290157 on anti-OVA polyclonal antibody-induced arthritis. Hutamekalin P, etal., J Pharmacol Sci. 2010;112(1):56-63. Epub 2010 Jan 6.
36. Association study of the C3 gene with adult and childhood asthma. Inoue H, etal., J Hum Genet. 2008;53(8):728-38. Epub 2008 Jun 20.
37. Genetic-biochemical criteria for individual sensitivity in development of occupational bronchopulmonary diseases. Izmerov NF, etal., Cent Eur J Public Health. 2002 Jun;10(1-2):35-41.
38. Complement C3 is required for the progression of cutaneous lesions and neutrophil attraction in Leishmania major infection. Jacobs T, etal., Med Microbiol Immunol. 2005 May;194(3):143-9. Epub 2004 Sep 17.
39. Intravenous immunoglobulin protects against experimental thrombotic microangiopathy. Jefferson JA, etal., Kidney Int. 2001 Sep;60(3):1018-25.
40. Suppression of complement regulatory proteins (CRPs) exacerbates experimental autoimmune anterior uveitis (EAAU). Jha P, etal., J Immunol. 2006 Jun 15;176(12):7221-31.
41. Inhibition of mannose-binding lectin reduces postischemic myocardial reperfusion injury. Jordan JE, etal., Circulation. 2001 Sep 18;104(12):1413-8.
42. Critical role of complement and viral evasion of complement in acute, persistent, and latent gamma-herpesvirus infection. Kapadia SB, etal., Immunity. 2002 Aug;17(2):143-55.
43. Involvement of complement in atopic dermatitis. Kapp A and Schopf E, Acta Derm Venereol Suppl (Stockh). 1985;114:152-4.
44. Phospholipase A in acute lung injury after trauma and sepsis: its relation to the inflammatory mediators PMN-elastase, C3a, and neopterin. Kellermann W, etal., Klin Wochenschr. 1989 Feb 1;67(3):190-5.
45. Renal C3 complement component: feed forward to diabetic kidney disease. Kelly KJ, etal., Am J Nephrol. 2015;41(1):48-56. doi: 10.1159/000371426. Epub 2015 Jan 30.
46. Innate immune defense against pneumococcal pneumonia requires pulmonary complement component C3. Kerr AR, etal., Infect Immun. 2005 Jul;73(7):4245-52.
47. Studies on type II collagen induced polyarthritis in rats. Effect of complement depletion. Kerwar SS, etal., J Immunopharmacol. 1981-1982;3(3-4):323-37.
48. Serum complement C3 predicts renal arteriolosclerosis in non-diabetic chronic kidney disease. Kojima C, etal., J Atheroscler Thromb. 2012;19(9):854-61. Epub 2012 Aug 1.
49. Potentiation of photodynamic therapy of cancer by complement: the effect of gamma-inulin. Korbelik M and Cooper PD, Br J Cancer. 2007 Jan 15;96(1):67-72. Epub 2006 Dec 5.
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51. Retinal synthesis and deposition of complement components induced by ocular hypertension. Kuehn MH, etal., Exp Eye Res. 2006 Sep;83(3):620-8. Epub 2006 May 4.
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PMID:26293614   PMID:26305563   PMID:26400934   PMID:26408241   PMID:26503818   PMID:26505407   PMID:26523990   PMID:26542163   PMID:26572892   PMID:26618866   PMID:26627825   PMID:26718342  
PMID:26767664   PMID:26897815   PMID:26914454   PMID:26945067   PMID:26986539   PMID:27013439   PMID:27029598   PMID:27029644   PMID:27085202   PMID:27099955   PMID:27113631   PMID:27116510  
PMID:27144164   PMID:27154286   PMID:27173435   PMID:27250206   PMID:27254108   PMID:27257040   PMID:27291248   PMID:27306948   PMID:27307199   PMID:27436813   PMID:27461873   PMID:27465068  
PMID:27492980   PMID:27497510   PMID:27662014   PMID:27717365   PMID:27747237   PMID:27801525   PMID:27814381   PMID:27900491   PMID:28095095   PMID:28174050   PMID:28188738   PMID:28192370  
PMID:28278205   PMID:28292891   PMID:28352659   PMID:28408754   PMID:28470643   PMID:28481947   PMID:28514442   PMID:28569420   PMID:28573137   PMID:28576324   PMID:28582497   PMID:28671664  
PMID:28675297   PMID:28687659   PMID:28697742   PMID:28739830   PMID:28742158   PMID:28801815   PMID:28855277   PMID:28860090   PMID:29029276   PMID:29036223   PMID:29113906   PMID:29155219  
PMID:29265514   PMID:29449217   PMID:29485352   PMID:29493039   PMID:29507755   PMID:29523638   PMID:29549164   PMID:29550264   PMID:29565179   PMID:29695177   PMID:29721183   PMID:29729435  
PMID:29742493   PMID:29791485   PMID:29850970   PMID:29872149   PMID:29888403   PMID:29968411   PMID:30078743   PMID:30104625   PMID:30110629   PMID:30139746   PMID:30139996   PMID:30156437  
PMID:30168048   PMID:30179527   PMID:30253188   PMID:30293775   PMID:30352574   PMID:30367535   PMID:30427941   PMID:30611277   PMID:30612786   PMID:30741587   PMID:30814081   PMID:30825266  
PMID:30989586   PMID:30998156   PMID:31180492   PMID:31254974   PMID:31273033   PMID:31315998   PMID:31409639   PMID:31433986   PMID:31594818   PMID:31797533   PMID:31829184   PMID:31899330  
PMID:31907994   PMID:31915256   PMID:31928530   PMID:31931851   PMID:31970928   PMID:31989759   PMID:32004338   PMID:32080985   PMID:32132668   PMID:32168099   PMID:32187754   PMID:32293297  
PMID:32296183   PMID:32305505   PMID:32328755   PMID:32499649   PMID:32571987   PMID:32682912   PMID:32724828   PMID:32794619   PMID:32929329   PMID:32938727   PMID:32986170   PMID:33022573  
PMID:33133060   PMID:33372665   PMID:33459487   PMID:33536243   PMID:33545068   PMID:33578311   PMID:33580248   PMID:33658012   PMID:33765255   PMID:33847934   PMID:33961781   PMID:34077925  
PMID:34105478   PMID:34117107   PMID:34205415   PMID:34233521   PMID:34360950   PMID:34424825   PMID:34700074   PMID:34707103   PMID:34711595   PMID:34732716   PMID:34842470   PMID:34905051  
PMID:34906905   PMID:34923262   PMID:34927448   PMID:34932275   PMID:35013218   PMID:35124280   PMID:35143312   PMID:35220210   PMID:35271311   PMID:35391932   PMID:35669782   PMID:35831314  
PMID:35871351   PMID:35944360   PMID:36439156   PMID:36591264   PMID:36605203   PMID:36643920  


Genomics

Comparative Map Data
C3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38196,677,704 - 6,720,650 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl196,677,704 - 6,730,562 (-)EnsemblGRCh38hg38GRCh38
GRCh37196,677,715 - 6,720,661 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36196,628,846 - 6,671,662 (-)NCBINCBI36Build 36hg18NCBI36
Build 34196,628,877 - 6,671,660NCBI
Celera196,619,402 - 6,662,926 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef196,440,030 - 6,483,146 (-)NCBIHuRef
CHM1_1196,678,095 - 6,720,521 (-)NCBICHM1_1
T2T-CHM13v2.0196,667,334 - 6,710,056 (-)NCBIT2T-CHM13v2.0
C3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391757,510,967 - 57,535,136 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1757,510,970 - 57,535,136 (-)EnsemblGRCm39 Ensembl
GRCm381757,203,967 - 57,228,136 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1757,203,970 - 57,228,136 (-)EnsemblGRCm38mm10GRCm38
MGSCv371757,343,396 - 57,367,559 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361756,889,309 - 56,913,426 (-)NCBIMGSCv36mm8
Celera1761,551,995 - 61,576,136 (-)NCBICelera
Cytogenetic Map17DNCBI
cM Map1729.72NCBI
C3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.292,087,437 - 2,114,366 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl92,087,437 - 2,114,429 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx92,515,463 - 2,542,310 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.097,864,836 - 7,891,685 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.096,820,692 - 6,847,542 (-)NCBIRnor_WKY
Rnor_6.099,721,137 - 9,747,084 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl99,721,105 - 9,747,167 (+)EnsemblRnor6.0rn6