RGD Reference Report - Comprehensive evaluation of complement components in the course of type I (Lepra) and type II (ENL) reactions. - Rat Genome Database

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Comprehensive evaluation of complement components in the course of type I (Lepra) and type II (ENL) reactions.

Authors: Sehgal, VN  Sharma, V  Sharma, VK 
Citation: Sehgal VN, etal., Int J Dermatol. 1989 Jan-Feb;28(1):32-5.
RGD ID: 7421527
Pubmed: PMID:2783924   (View Abstract at PubMed)

Complement components C1q and C4 of classic pathway; C3d, a breakdown product of C3, and factor B of alternate pathway: and C3, a component both of classic and alternate pathways, were studied in 35 patients, comprising 18 type I (Lepra) and 17 type II (ENL) reactions. There was a significant decrease in C3 and factor B with a concomitant rise of C3d during ENL. These changes indicate their preeminent role in immunogenesis of type II (ENL) reaction. The changes in the classic pathway components, on the other hand, were insignificant, apparently suggesting its limited involvement in ENL. Furthermore, reversion of factor B and C3d after subsidence of reaction is intriguing and may indicate that they are not substantially affected even with contemporary treatment. Complement components, of both classic and alternate pathways, showed no significant alterations either during type I (Lepra) reaction or after its amelioration.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
C3Raterythema nodosum  ISOC3 (Homo sapiens)associated with LeprosyRGD 
C3Humanerythema nodosum  IEP associated with LeprosyRGD 
C3Mouseerythema nodosum  ISOC3 (Homo sapiens)associated with LeprosyRGD 
CFBHumanerythema nodosum  IEP associated with LeprosyRGD 
CfbRaterythema nodosum  ISOCFB (Homo sapiens)associated with LeprosyRGD 
CfbMouseerythema nodosum  ISOCFB (Homo sapiens)associated with LeprosyRGD 

Objects Annotated

Genes (Rattus norvegicus)
C3  (complement C3)
Cfb  (complement factor B)

Genes (Mus musculus)
C3  (complement component 3)
Cfb  (complement factor B)

Genes (Homo sapiens)
C3  (complement C3)
CFB  (complement factor B)


Additional Information